Gene

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LYZL6 lysozyme-like 6 [ Homo sapiens ]

Gene ID: 57151, updated on 14-Aug-2011

Summary
Official Sym bol LYZL6 provided by HGNC Official Full Nam e Prim ary source Locus tag See related Gene type RefSeq status Organism Lineage Also know n as lysozyme-like 6 provided by HGNC HGNC:29614 UNQ754/PRO1485 Ensembl:ENSG00000161572; HPRD:14339; MIM:612751 protein coding REVIEWED Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo LYC1; UNQ754; PRO1485; TKAL754 lactalbumins mediate lactose biosynthesis. The encoded protein contains catalytic residues characteristic of C-type lysozymes and may play a role in male reproduction. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]

Sum m ary This gene encodes a member of the C-type lysozyme/alpha-lactalbumin family. C-type lysozymes are bacteriolytic factors that play a role in host defense, w hereas alpha-

Genomic context
Location : 17q11.2 Sequence : Chromosome: 17; NC_000017.10 (34261522..34270703, complement) See LYZL6 in MapView er Chrom osom e 17 - NC_000017.10

Genomic regions, transcripts, and products

Go to reference sequence details Genom ic Sequence NC_000017 chromosome 17 reference GRCh37.p5 Primary Assembly Go to nucleotide -34,272,887 : -34,260,952 (11,936 bases shown, negative strand) Graphics FASTA GenBank

Bibliography
Related articles in PubMed
1. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965. 2. Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alphalactalbumin family. Zhang K, et al. Biol Reprod, 2005 Nov. PMID 16014814. 3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334. 4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res,
2003 Oct. PMID 12975309.

5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932. See all (7) citations in PubMed See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Subm it: New GeneRIF Correction

What's a GeneRIF?

Phenotypes
Review eQTL and phenotype association data in this region using PheGenI

General gene information

Markers
RH92094 (e-PCR) UniSTS:83683

Genotypes
See LYZL6 SNP Geneview Report See LYZL6 SNP Genotype Report

Homology
Homologs of the LYZL6 gene: The LYZL6 gene is conserved in chimpanzee, cow , mouse, and rat. Map View er (Mouse, Rat)

Gene Ontology Provided by GOA

Function hydrolase activity, acting on glycosyl bonds lysozyme activity Process cell w all macromolecule catabolic process metabolic process Com ponent extracellular region Evidence Code IEA IEA Evidence Code IEA IEA Evidence Code IEA Pubs Pubs Pubs

General protein information

Preferred Names lysozyme-like protein 6 Names lysozyme-like protein 6 lysozyme homolog OTTHUMP00000163949 OTTHUMP00000163950 NP_001186880.1 EC 3.2.1.17 NP_065159.1 EC 3.2.1.17

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes
These reference sequences exist independently of genome builds. Explain mRNA and Protein(s) 1. NM_001199951.1 NP_001186880.1 lysozym e-like protein 6 precursor Status: REVIEWED
Description Source sequence(s) UniProtKB/Sw iss-Prot Related Ensembl Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. AY742214, BC054481, BE550275, DB462957 O75951 ENSP00000293274, ENST00000293274 cd00119 Location:22 142 Blast Score: 394 LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...

Conserv ed Domains (1) summary

2.

NM_020426.2 NP_065159.1 lysozym e-like protein 6 precursor Status: REVIEWED

Description Source sequence(s) Consensus CDS Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. AY742214, BE550275, BG195727 CCDS11302.1

Consensus CDS UniProtKB/Sw iss-Prot Related Ensembl

CCDS11302.1 O75951 ENSP00000378031, ENST00000394523 cd00119 Location:22 142 Blast Score: 394 LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...

Conserv ed Domains (1) summary

RefSeqs of Annotated Genomes: Build 37.3

The follow ing sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic 1. NC_000017.10 Reference GRCh37.p5 Prim ary Assem bly
Range Dow nload 34261522..34270703, complement GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef
Genomic 1. AC_000149.1 Alternate HuRef
Range Dow nload 30446535..30455714, complement GenBank, FASTA, Sequence Viewer (Graphics)

Related Sequences
Nucleotide Heading genomic genomic genomic genomic genomic mRNA mRNA mRNA mRNA mRNA mRNA other-genetic Accession and Version AC004675.1 (64089..69074) AF088219.1 CH471147.2 HC007140.1 HC044567.1 AY359018.1 AY742214.1 BC054481.1 BE550275.1 BG195727.1 DB462957.1 HQ447665.1 Links Protein Accession O75951.1 GenePept Link GenPept UniProtKB Link UniProtKB/Sw iss-Prot:O75951 Protein None AAC63332.1 EAW80115.1 CBH19375.1 CBH30613.1 AAQ89377.1 AAU93343.1 AAH54481.1 None None None ADQ32150.1

Additional Links
Additional Links
MIM 612751 UCSC UCSC UniGene Hs.97477

Gene LinkOut
The follow ing LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links. Molecular Biology Databases pfSNP NextBio KOMP Repository Kyoto Encyclopedia of Genes and Genomes hsa:57151 InnateDB Ingenuity Pathw ays Analysis iHOP - Information Hyperlinked over Proteins HuRef Brow ser HuRef Genome Annotation BioGPS

GeneNetw ork Records for gene expression in Human GeneGo FuncBase Gene Function Prediction View er Predicted Gene Functions Domain Mapping of Disease Mutations LYZL6 BioLink: Biological know ledge connections CREB Target Gene Database The Comparative Toxicogenomics Database LYZL6 Research Materials GeneCopoeia Inc. Order shRNA clones Order full-length ORF clone ExactAntigen/Labome others protein and peptide cDNA clone siRNA and shRNA antibody TaqMan probe and primer sets from Applied Biosystems Gene Expression Assays Genotyping Assays Silencer Select siRNA Tools GeneMANIA Miscellaneous QIAGEN GeneGlobe