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In October, Australian reproductive sentation in the media and public hysbiologist Alan Trounson, another teria to get in the way of legitimate scimember of the HCPI, publicly likened entific exchange, Tipton told the JCI. the risk of human A question of time cloning to that of the misuse of nuclear armaTipton went on to ments. Given that most explain ASRMs policy existing animal clones with regard to human have health defects such cloning. We would not as obesity and respiratolet people present ry and immune probsomething that said lems, he said, children here are the results of born from the technique Human embryo at the tenhuman cloning. Heres could face death at any cell stage. a baby. But Dr. Zavos point in time, and that work did not present an this was an unreasonable way to live. ethical obstacle. He didnt move anyMassey is also an HPCI member. The thing any closer to whats happening in reason I joined the panel is because I human cloning. Weve taken a clear, know there are people out there who scientific stance against that because would try to clone their loved ones or the science hasnt progressed to a point themselves if they thought they had a where you can make an attempt at it shot at it. They will continue to be tan- safely. We havent addressed the ultitalized by the promises of the fringe ele- mate ethical question of should it ever ments who take advantage of the press happen. Were still examining that and to promote awareness of their activities. our membership is torn on it. There are Those who are making the claims, and a lot of people who recognize that have no science, need to be discredited. much of the debate around human This is a goal of the HCPI, promote sci- cloning is very similar to that which ence, and discourage the hope for surrounded the first in vitro fertilizareproductive cloning. tion. Until the scientific question is Other scientific groups are also clear, we have not felt the need to take mobilizing. In September, more than up the larger ethical question as yet. 60 science academies from around the That point may be a long way off. world, under the auspices of the Inter- First of all, I think its highly unlikely Academy Panel, petitioned the UN to that Zavos would have frozen it at the adopt a ban on reproductive cloning 10-cell unless it had stopped dividing, while urging against making thera- and if had, it wouldnt be viable, says peutic cloning illegal. Lanza, whose company has cloned However, such activity has not around 100 cows. Also, in all probabilsilenced the claims of proponents of ity, 10 cells may not really be 10 cells but human cloning. Zavos is becoming a may be a fractionated embryo, i.e., cells familiar figure at reproductive biology have broken into smaller units. The meetings around the world. At the human genome doesnt really kick in ASRM meeting, he presented data on until the compacting morula stage, nuclear transfer in cow embryos as a which is at least a 16-cell. And when it model for his human work. Perhaps, starts to compact there are certain genes then, it is incumbent on societies to that are turned on so that you would be take a stance and not give rogue scien- able to visibly ensure that a clone has tists a platform. ASRM spokesperson taken over and that its viable. Sean Tipton disagrees. The scientific Moreover, credible cloning researchers community shouldnt allow misrepre- are currently debating whether primate
embryos can ever undergo successful nuclear transfer, since meiotic spindle removal from recipient oocytes, which occurs during enucleation, appears to prevent embryo reconstitution (2). Although others believe its simply a numbers game, Mark Westhusin, a member of the Texas A & M University team that cloned the first cat, told the JCI, The nuclear transfer procedure is not the obstacle. The biggest issue is logistics. Its very inefficient in any species, so where are you going to get 100 eggs on any given day that are competent and can reprogram a nucleus, and where are you going to get enough surrogate mothers, let alone a research team willing to be a part of this? Thus, despite the UNs wranglings, it still seems that time is on their side
in their attempt to introduce an international cloning law that will please the majority. But Joe Masseys words should serve as a strong incentive to act sooner rather than later: If 100 scientists learned to clone human cells, only one would be needed to blow the lid off the science and take it to reproduction.
1. Tamashiro, K.L., et al. 2002. Cloned mice have an obese phenotype not transmitted to their offspring. Nature Med. 8:262267. 2. Simerly, C., et al. 2003. Molecular correlates of primate nuclear transfer failures. Science. 300:297.
December 2003
Volume 112
Number 11
1601