VPHAR 205 - CHLMOTHLRAPIITICS

SY 2011-2012






CASL RLPORT






GROIP MLMBLRS:
ALVARLZ, Susanc||c L.
CIASAY, Jcromc G.
PAGADIAN, Javson T.



SIBMITTLD TO:
NORAINL P. MLDINA, DVSM, MSc
Dcpar|mcn| ol Morphophvsiolov and Pharmacolov




CASL STIDY: CANINL DISTLMPLR
Spccics: Caninc A||cndin Vc|crinarian: Dr. Rodcrick T.
Salvador
Namc ol Pa|icn|: Chiqui|i|a Kiki" Addrcss ol |hc Clinic: AMC, CLSI
Ac: 6 mon|hs old Vcih|: 5 k Scx: Icmalc Color: aprico|
Owncr: Ms. Lca Mac Paav Con|ac| -: 09052172700
Addrcss ol |hc Owncr: Sawmill, CLSI
Casc Rcpor|
His|orv:
Thc animal had bccn sullcrin lrcqucn| vomi|in lor |hrcc davs. Thc lcccs ol |hc animal
had bccn vcrv loul on |hc sccond dav al|cr |hc lirs| vomi|. Thc animal also sullcrcd inappc|cncc
lor |wo davs, |hc animal onlv drinks wa|cr. Thc animal had bccn adminis|crcd IVOMLC bv |hc
owncr upon appcarancc ol |hc sins.
Clinical Iindins:
Vomi|in
Ioul odor diarrhca
Inappc|cncc
Hcad and bodv shakin
Pan|in
Nasal discharc





Chiqui|i|a al|cr |rca|mcn|
Dianos|ic Proccdurcs:
DIS - nca|ivc
Dianosis:
Tcn|a|ivc: Caninc Dis|cmpcr
Thcv arrivcd in |his dianosis bccausc |hc animal shows clinical sins samc in caninc dis|cmpcr
likc:
Rcspira|orv- nasal discharc
GIT- vomi|in, diarrhca
CNS - hcad and bodv shakin

Trca|mcn| Rcimcn:
1. Scp|o|rvl - 0.` ml sid IV
2. Mc|oclopramidc HCl - 1.8 ml q4h IV
`. Vi|amin B-Complcx - 1 ml sid IV
4. Ami|op - 1 ml sid IV
5. Lncrsidcx - 1ml sid IV
6. Ornipural - 1ml sid IV
7. Dcx|rosc 5 - lor |hrcc davs

Dosc rcimcn
|imc Dav 1 2 `
SLPTOTRYL
0.` ML Sid IV
11:``
11:56
MLTOCLOPRAMIDL
1.8 ml q4h IV
11:`2 am
`:`2 pm
7:`2
11:`2 pm
`:`2 am
7:`2 am
1:`2 pm
7:`2 pm
1:`2 am

B- COMPLLX
1 ml sid IV
7:40
9:05
AMITOP
1 ml sid IV
8:10
10:1`
LNLRGIDLX
1ml sid IV
7:55am
10:`7 am
ORNIPIRAL
1 ml sid IV
8:28
9:20
VIT C 8:45 pm
9:`5 am

Discussion:
Caninc Dis|cmpcr is causcd bv a paramvxovirus closclv rcla|cd |o |hc viruscs ol mcaslcs
and rindcrpcs|. Thc cnvclopcd virus is scnsi|ivc |o lipid solvcn|s and mos| disinlcc|an|s and is
rcla|ivclv uns|ablc ou|sidc |hc hos|. Thc main rou|c ol inlcc|ion is via acrosol droplc| sccrc|ions
lrom inlcc|cd animals. Somc inlcc|cd dos mav shcd virus lor scvcral mon|hs.
Virus rcplica|ion ini|iallv occurs in |hc lvmpha|ic |issuc ol |hc rcspira|orv |rac|. A ccll-
associa|cd vircmia rcsul|s in inlcc|ion ol all lvmpha|ic |issucs, which is lollowcd bv inlcc|ion ol
rcspira|orv, GI |rac| and urocni|al cpi|hclium, as wcll as |hc CNS. Discasc lollows virus
rcplica|ion in |hcsc |issucs. Thc dcrcc ol vircmia and cx|cn| ol sprcad ol virus |o various |issucs is
modcra|clv bv |hc lcvcl ol spccilic humoral immuni|v in |hc hos| durin |hc vircmic pcriod.
Thc |rca|mcn| rcimcn uscd is as lollows: (ai Scp|o|rvl (Sulphadiazinc 200m
Trimc|hoprim 40m, 0.` mli sid via IV rou|c, (bi Mc|oclopramidc HCl, 1.8 ml cvcrv lour hours,
IV rou|c, (ci Vi|amin B-complcx, 1ml, (di Ami|op, 1ml, (ci Lncrcidcx, 1ml, (li Ornipural, 1ml via
IV rou|c.
Thc an|i-cmc|ic ac|ion ol Mc|oclopramidc is duc |o i|s an|aonis| ac|ivi|v a| D2 rcccp|ors in
|hc chcmorcccp|or |ricr zonc (CTZi in |hc ccn|ral ncrvous svs|cm (CNSi-|his ac|ion prcvcn|s
nausca and vomi|in |ricrcd bv mos| s|imuli. Al|cr |hc adminis|ra|ion ol |his dru |hc vomi|in
s|ops. Onlv mild saliva|ion is obscrvcd al|crward.
Thc B vi|amins mav bc ncccssarv |o: ai Suppor| and incrcasc |hc ra|c ol mc|abolism. bi
Main|ain hcal|hv skin and musclc |onc. ci Lnhancc immunc and ncrvous svs|cm lunc|ion. di
Promo|c ccll row|h and division, includin |ha| ol |hc rcd blood cclls |ha| hclp prcvcn| ancmia.
Scp|o|rvl (Sulphadiazinc 200m Trimc|hoprim 40mi is indica|cd in |hc |rca|mcn| ol svs|cmic
inlcc|ions causcd bv or associa|cd wi|h oranisms. Thcv uscd an|ibac|crial dru |o prcvcn|
oppor|unis|ic bac|cria lrom causin diarrhca. Thcv choosc |his po|cn|ia|cd sullonamidc dru
bccausc i| has a widc ranc ol an|ibac|crial ac|ion. Ami|op (supplcmcn|arv vi|amins mincrals and
dcx|rosc,i. Ornipural (Sorbi|ol 200 m
Clorhidra|o dc Arinina ``.` m, Bc|aina 15 m, Clorhidra|o dc Orni|ina 11.8 m, L-ci|rulina 10
m,
Mc|acrcsol ` m, Lxcipicn|c c.b.p. 1 mli is a livcr |onic, pro|cc|an| lor |hc |oxins. This dru is
ncccssarv |o kccp |hc normal lunc|ion ol |hc livcr. I| nccds |o bio|ranslorm |hc drus |ha| arc
adminis|cr durin |hc |rca|mcn|.
Al|cr |hrcc davs ol conlincmcn|, |hc animal was linc and had bccn rclcascd lrom |hc
hospi|al. Thc owncr was advisc |o rc|urn |hc animal a wcck al|cr i| was rclcascd lrom |hc hospi|al
lor lollow up chcck up.