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A young man is rescued from a fire and brought to the emergency department (located at sea level). The
patient is unconscious, but his vital signs (heart rate, blood pressure, respiratory rate) are stable. Below are
arterial blood gas data, from a sample drawn while he is breathing 100% oxygen.
1. What is the relative position of his HbO2 equilibrium curve compared to normal? Is the curve pushed
upward or downward? Is it shifted to the left or right? Explain the effect of the changes in his HbO 2
equilibrium curve on:
The amount of oxygen delivered from the lungs to the tissue capillaries
The amount of oxygen delivered from the tissue capillaries to the individual tissue cells
The patient's HbO2 equilibrium dissociation curve is shifted downward and to the left.
Curve shifted down. Carbon monoxide displaces oxygen from hemoglobin at the pulmonary capillary
level. This downward shift of the curve results in a lower SaO 2 for a given PaO2. To the extent that SaO 2
falls, arterial oxygen content and delivery are reduced. However, the physiologic process of delivering
Curve shifted to left. The curve is shifted to the left for two reasons: effect of carbon monoxide (the
major reason in this example) and the increased pH (relatively minor). A left shift indicates an increase
in the amount of oxygen taken up by hemoglobin in the pulmonary capillaries; this results in a higher
SaO2 for a given PaO2 (See Fig. 36-5 and p. 594 in Physiology 3rd ed.) To the extent that SaO2
increases, arterial oxygen content and delivery are increased. However, at the pulmonary capillary
level, the leftward shift has much less effect than does the downward shift from carboxyhemoglobin; as
a result, SaO2 is always reduced in carbon monoxide poisoning. The leftward shift is actually
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detrimental, because it inhibits oxygen unloading in the systemic capillaries. Thus oxygen delivery from
the systemic capillaries to the tissue cells is reduced, because hemoglobin holds on to oxygen more
It lowers SaO2 and O2 content and thereby lowers oxygen delivery to the systemic capillaries.
It impairs transport of oxygen from the systemic capillaries to the tissue cells.
2. Is his PaO2 less than, equal to, or higher than expected under the circumstances (100% inspired oxygen,
normal PaCO2)? Explain your answer.
Because this patient is breathing 100% oxygen, his PaO 2 amounts to about 660 mm Hg (use the
alveolar gas equation provided in questions on Chapter 33). The difference between alveolar and
arterial PO2 normally widens with increasing FIO 2, but even with 100% inspired oxygen the (PAO 2
¨C PaO2) should be no more than about 100 mm Hg. Hence, when the patient breathes 100% oxygen,
PaO2 should be at least 500 mm Hg. His PaO2, while seemingly high at 190 mm Hg, is actually much
less than expected for his FIO2. This lower-than-expected PaO2 is not caused by an excess of CO per se;
CO does not affect the PaO2, only the SaO2 for a given PaO2. The explanation for reduced PaO2 must lie
in V/Q imbalance, which in turn must arise from some parenchymal lung problem (e.g., pulmonary
edema from smoke inhalation). Thus the physiologic data indicate a parenchymal lung problem from
Excess CO, which impairs oxygen uptake by hemoglobin and oxygen delivery to the tissues, and V/Q
imbalance, not directly caused by CO, that impairs oxygen transfer across the alveolarcapillary
membranes.
3. What is the relative affinity of CO and O2 for hemoglobin? Based on this information, how should a victim
of CO poisoning be treated?
CO has 250 times the affinity for hemoglobin as does oxygen. Fortunately, the binding of CO to
hemoglobin is reversible; once the patient is removed from the CO source, this poison will begin to be
displaced by oxygen. However, displacement is slow at physiologic PO2 values (80 to 100 mm Hg),
where the half-life of COHb is about 6 hours. The higher the PO2, the more quickly O2 will displace CO
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from hemoglobin. Because CO-poisoned patients may die or suffer brain damage if not treated quickly,
a high inspired oxygen pressure is mandatory therapy. The following table shows that the higher the
4. Describe and explain how each of the following conditions would affect this patient's PaO2, SAO2, and
arterial oxygen content. Assume that each condition occurs alone (i.e., nothing else is abnormal).
Physiologic problems rarely occur in isolation, but here you are to assume nothing else is abnormal
Anemia NE NE D
Excess CO NE D D
Fever NE D* D
Acidosis NE D* D
Alkalosis NE I* I
Hypoventilation D D D
Hyperventilation I I I
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V/Q imbalance D D D
High altitude D D D