Side Effects of Biperiden - for the Consumer

Biperiden
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Biperiden: Agitation; blurred vision; constipation; dizziness or lightheadedness when sitting up or standing; drowsiness; dry mouth, nose, or throat; nausea; nervousness; stomach upset. Seek medical attention right away if any of these SEVERE side effects occur when using Biperiden: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); anxiety; behavior changes; chest pain; confusion; disorientation; exaggerated sense of well-being; fast, slow, or irregular heartbeat; flushing; hallucinations; loss of coordination; memory loss; mood or mental changes; seizures; trouble urinating. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
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Side Effects by Body System - for Healthcare Professionals

Nervous system
A case of choreic movements was reported in a patient on concomitant therapy of biperiden and carbidopa/levodopa. Nervous system side effects have included drowsiness, choreic movements, reduced rapid eye movement sleep, and anticholinergic syndrome. Symptoms of central anticholinergic syndrome include: dilated, sluggish pupils; warm, dry skin; flushing; decreased respiratory tract secretions; foul breath; increased body temperature; decrease bowel sounds; urinary retention; tachycardia/cardiac arrhythmias;delirium, disorientation, anxiety, hallucinations, confusion, incoherence; agitation; hyperactivity, ataxia, loss of memory; paranoia; combativeness and seizures. Central anticholinergic syndrome may progress to stupor, coma, paralysis, cardiac/respiratory arrest and death. Orthostatic dizziness, hypokinesia, and headache have also been reported.

Gastrointestinal
Gastrointestinal side effects have included dry mouth, constipation, gastric irritation, nausea, vomiting, and increased salivation.

Psychiatric

Psychiatric side effects have included euphoria, disorientation, agitation, disturbed behavior, and concentration difficulties.

Other
Other side effects have included asthenia.

Hypersensitivity
Hypersensitivity side effects have included allergic skin reactions.

Genitourinary
Genitourinary side effects have included urinary retention.

Ocular
Ocular side effects have included blurred vision.

Cardiovascular
Postural hypotension and bradycardia may be minimized or eliminated by slow intravenous administration. Cardiovascular side effects have included postural hypotension and bradycardia when administered parenterally.

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