Agaricus Blazei Murrill Mushroom Extract

Agaricus is the most widely consumed mushroom in many countries, where it is regarded as a health food, due to its medicinal properties. Agaricus is traditionally known as "God's Mushroom" because of its near miraculous curative benefits to a wide range of disorders. People have used it to overcome numerous diseases and disorders relating to the immune system, cardiovascular system, digestion, and for weight management, Agaricus Mushroom diabetes, chronic and acute allergies, cataracts, hearing difficulties, stress syndrome, chronic fatigue, diarrhea, constipation, and disorders of the liver. A few decades ago, researchers noticed that in the mountain region of Ideate near Sao Paulo, Brazil , a regular part of the local inhabitants' diet was a mushroom known as "Cogmelo de Deus" or "Mushroom of God". The researchers also noted that the local inhabitants were extraordinarily healthy and had a very low incidence of disease, which they attributed to this magical mushroom. The scientific name of the mushroom is Agaricus Blazei Murrill, more commonly called the ABM mushroom and sometimes referred to as Agaricus Brasiliennis. So potent is this mushroom that one well-known rainforest herbal manufacturer, uses it as the main ingredients in herbal supplements that have been credited with success against cancer and other diseases around the world. In a study conducted by Dr. Shoji Shibata, a professor at Tokyo University , several other well known cancerfighting and immune-boosting mushrooms were compared to the ABM, including Reishi and Shitake. Dr. Shibata's results found that the other mushrooms were not as effective as the ABM mushroom, and so the ABM was ranked at the top of the list of potent mushrooms - a spot befitting the "Mushroom of God"! Other Japanese and British studies have also shown the ABM mushroom to have the highest concentration of beta-glucan of any mushroom. Contains Beta-(1-3)-D-glucan, Beta-(1-4)-a -D-glucan & Beta - (1-6)-D-glucan. Known collectively as Betaglucans, these long-chain polysaccharides are the most potent immuno-potentiating (immune enhancing) substances yet found. They also have very powerful anti-tumor properties. When human subjects are given AMB in their diet, a 3000% increase of NK cells, a type of anti-tumor white blood cell known as Natural Killer cells, is seen in the blood within 2-4 days. In addition to beta glucans, agaricus also contains derivatives of ergosterol, a potent anti-tumor agent; double stranded RNA, an anti-viral agent; proteoglucans and protein bound polysaccharides of low molecular weight, which are immune enhancers; and, protein bound polysaccharides of high molecular weight, vitamins B1 and B2, proteins in the form of amino acids, niacin, iron, and calcium. There are many verified reports from around the world of this mushroom being used successfully in late stage cancers that had been determined hopeless and some clinics in Europe base their entire treatment protocols on agaricus blazei murrill mushroom extracts and other complimentary botanicals. In fact, in many published studies, the rate of cure for all types of cancer has been in the high ninety percentile range, even for stage 4 lung cancer, where many complete remissions are often seen in just a few weeks.

Coriolus Versicolor extract - from the Asian Turkey Tail mushroom.

Contains polysaccharides [PSK] and polysaccharopeptides [PSP] effective for acute leukemia and stomach, esophagus, colorectal, lung cancer; PS is effective with many types of cancer (at least early and mid-stage cancer), including lung cancer and particularly stomach & colon cancer. NCI reportedly stated that PSK has been "contemplated for use against... mammary cancer, gastrointestinal cancers, such as those of the esophagus, Turkey Tail Mushroom stomach, colon, lung and brain tumors" and that PSP "has...anti-tumor activities, inhibiting Ehrlich ascites tumors, leukemia, and sarcoma, gastric

tumor, lymph, and monocytic leukemia". Good to take during chemo & radiation - including acute leukemia patients)

Shitake Mushrooms
Shiitake (for centuries called "Elixir of Life" ) has been licensed as a anti-cancer drug by the Japanese FDA. Lentinan has shown some effect on bowel cancer, liver cancer, stomach cancer, ovarian cancer and lung cancer. Lentinan stimulates the production of T lymphocytes and natural killer cells and can potentiate the effect of AZT in the anti-viral
Shitake Mushroom

treatment of A.I.D.S. Shiitake is rich in several anti -oxidants

(Selenium, Uric acid & Vitamin A, E, & C) as well as Vitamin D. Shiitake mushrooms may also lower blood pressure in those with hypertension, lower serum cholesterol levels, increase libido, stimulate the production of Interferon which has anti-viral effects, and has proven effective against Hepatitis in some cases.
The shiitake (Lentinula edodes) is an edible mushroom native to East Asia. It is generally known in the Englishspeaking world by its Japanese name, shiitake. Shiitake are native to China but have been grown in both Japan and China since prehistoric times. They have been cultivated for over 1000 years. Fresh and dried shiitake have many uses in the cuisines of East Asia. In Chinese cuisine, they are often sauteed in vegetarian dishes such as Buddha's delight. In Japan, they are served in miso soup, used as the basis for a kind of vegetarian dashi, and also as an ingredient in many steamed and simmered dishes. (lowers cholesterol and improves immune system function, good for preventing high blood pressure and heart disease, for controlling cholesterol level, building resistance against viruses, and fighting diseases such as AIDS/HIV and cancers. Often available fresh, Shitake mushrooms are very flavorful when used in cooking! If you cannot find fresh, available as a supplement also.)

Maitake Mushrooms

Maitake is also known by the name Dancing Mushroom, famous for its taste and health benefits. In Japan, Maitake Mushroom is called "King of Mushroom". The fruiting body and the mycelium of Maitake are used medicinally. In China and Japan, Maitake Mushrooms have been consumed for 3000 years. Years ago in Japan, the Maitake had monetary value and was worth its weight in silver. Historically, Maitake has been used as a tonic
Maitake Mushroom

and adaptogen. It was used as a food to help promote wellness and vitality. Traditionally, consumption of the mushroom was thought to

prevent high blood pressure and cancer - two applications that have been the focal point of modern research. Clinical research with Maitake Mushroom has increased dramatically in the past several years. Laboratory studies have shown that Maitake Mushroom extract can inhibit the growth of tumors and stimulate the immune system of cancerous mice.
Grifola frondosa, referring to a mythical griffin, commonly known as Sheep's Head, Ram's Head and Hen of the Woods or Maitake, is an edible polypore mushroom. It grows in clusters at the foot of trees, especially oak. The Japanese call it "maitake" (pronounced [maitake]), literally meaning "dancing mushroom." The underground tubers from which hen of the woods arises has been used in traditional Chinese and Japanese medicine to enhance the immune system. Researchers have also indicated that whole maitake has the ability to regulate blood pressure, glucose, insulin, and both serum and liver lipids, such as cholesterol, triglycerides, and phospholipids, and may also be useful for weight loss. (high in nutrients including Vitamins B-2, C, D, niacin, magnesium, potassium, fiber, and amino acids, contains the polysaccharide compound beta-1.6-glucan which naturally stimulates the immune system and lowers blood pressure. Beneficial for obesity and diabetic patients, the Maitake mushroom may be best known for its cancer fighting ability. Tests in mice prove that it blocks tumor formation and boosts the immune system. Available fresh or as supplement).

Reishi Mushrooms
Reishi has been called an "immune potentiator." Recent studies have indicated that Reishi can have a number of other effects: Analgesic, Anti-inflammatory, Antioxidant, Antiviral through inducing interferon production, Lowers blood pressure, Cardiotonic action through lowering serum cholesterol, Expectorant & Antitussive, Liver (Hepatitis)-protecting and detoxifying, protection against ionizing radiation, Antibacterial, and Anti-HIV activity. Reishi contains calcium, iron and phosphorus as well as vitamins C, D, and B including pantothenic acid, which is essential to nerve function and the adrenal glands.

Reishi Mushroom

The reishi mushroom is also known as Ling-Zhi in Chinese. They are an Asian form of Ganoderma lucidum and a polypore mushroom which are categorized as tough and leathery. Physically, "reishi mushrooms are large, very dark and woody-looking mushrooms. While most mushrooms are 90% water, reishi mushrooms are 75% water." In order to consume them internally, they must be made into

a tea or an extract. (The Reishi mushroom can increase the production of interleukin1 and 2, resulting in inhibition of tumor growth. Studies show that Reishi can have a number of other positive effects on the body such as analgesic, anti-inflammatory, antioxidant, anti-viral (through its interferon production), lowers blood pressure. It also acts as a cardiotonic by lowering serum and increasing the production of interleukin 1 and 2, which results in inhibition of tumor cholesterol, expectorant, anti-tissue, liver protecting and detoxifying, protection against ionizing radiation, antibacterial, and anti-HIV activity. Available fresh or as supplement).

Cordyceps Ophioglossoides Mushroom

(Cordyceps, like many other medicinal mushrooms, contains complex sugars (especially beta 1,3 glucan) and other nutrients (nucleosides, triterpeniods) which seem to strongly nourish and activate various components of the immune system, useful in treating cancer, chronic fatigue and other immune disorders. Cordyceps can be a powerful stimulant for macrophage activity, Cordyceps Mushroom strengthening your immune system's ability to fight against bacterial and viral infection.

Human clinical studies indicate that Cordyceps can be effective for treatment of high cholesterol, poor libido/impotence, arrhythmia, lung cancer, and chronic kidney failure. It is also reported that Cordyceps causes smooth muscle relaxation. This can make it especially helpful for treating chronic cough asthma, and other s, bronchial conditions. It also seems to have value in treating nephritis, may help the immune system recognize tumors that otherwise might escape immune surveillance, and has positive effects on the cardiovascular and nervous systems, and an anti-aging effect.)

Yun Zhi Mushroom

Yun-zhi, generally called "zhi" in ancient times, refers to a cloud-like mushroom with health-promoting qualities. Yun Zhi, or the Cloud Mushroom, has been used to dispel dampness, reduce phlegm, treat pulmonary infections, to strengthen the tendons and bones, for vital energy, and to support liver health. YunZhi Mushroom Researchers and traditional herbalists have discovered that polysaccharides

in Yunzhi mushroom possess broad immune stimulatory properties that helps to boster the body's defenses against microbes and an array of cancers. Benefits - Assists with immune function, high in vegetable proteins, promotes good health and vitality. Yunzhi polysaccharides have been shown to maintain the immune system in a healthy condition, or boost an immune system by increasing white blood cell count, the primary agents of the body responsible for fighting infection, helping to reduce nausea and discomfort.

Conclusion The world of natural health has an abundance of botanicals, vitamins, minerals and supplements to help fight illness and boost the immune system. As you can see, the so-called "medicinal mushrooms" are important parts of that world. Live long, live healthy, live happy! Warning: It is extremely important that you research mushrooms thoroughly if you intend to harvest your own wild mushrooms because many varieties are highly poisonous! It is advisable to purchase mushrooms from a reputable grower or grocer rather than hunting them yourself.

Read more: http://www.disabled-world.com/artman/publish/mushrooms.shtml#ixzz1NFZRyLL2

Cordyceps
From Wikipedia, the free encyclopedia Jump to: navigation, search

Cordyceps

Cordyceps ophioglossoides

Scientific classification Kingdom: Subkingdom: Phylum: Subphylum: Class: Subclass: Order: Family: Genus: Fungi Dikarya Ascomycota Pezizomycotina Sordariomycetes Hypocreomycetidae Hypocreales Clavicipitaceae Cordyceps Species

C. bassiana (Bals.-Criv.) C. gunnii C. militaris C. ophioglossoides C. sinensis C. subsessilis (Petch) C. unilateralis Cordyceps is a genus of ascomycete fungi (sac fungi) that includes about 400 described species. All Cordyceps species are endoparasitoids, mainly on insects and other arthropods (they are thus entomopathogenic fungi); a few are parasitic on other fungi. The best known species of the genus is Cordyceps sinensis,[1] first recorded as yartsa gunbu in Tibet in the 15th Century.[2] It is known as yartsa gumba in Nepal. The Latin etymology describes cord as club, ceps as head, and sinensis as Chinese. Cordyceps sinensis, known in English commonly as caterpillar fungus, is considered a medicinal mushroom in oriental medicines, such as Traditional Chinese medicines[3] and Traditional Tibetan medicine.

When a Cordyceps fungus attacks a host, the mycelium invades and eventually replaces the host tissue, while the elongated fruiting body (stroma) may be cylindrical, branched, or of complex shape. The stroma bears many small, flask-shaped perithecia contain the asci. These in turn contain the thread-like ascospores, which usually break into fragments and are presumably ineffective. Some Cordyceps species are able to affect the behavior of their insect host: Cordyceps unilateralis causes ants to climb a plant and attach there before they die. This ensures the parasite's environment is at an optimal temperature and humidity and maximal distribution of the spores from the fruiting body that sprouts out of the dead insect is achieved.[4] Marks have been found on fossilised leaves which suggest this ability to modify the host's behaviour evolved more than 48 million years ago.[5] The genus has a worldwide distribution and most of the approximately 400 species[6] have been described from Asia (notably Nepal, China, Japan, Korea and Thailand). Cordyceps species are particularly abundant and diverse in humid temperate and tropical forests. The genus has many anamorphs (asexual states), of which Beauveria (possibly including Beauveria bassiana, Metarhizium, and Isaria) are the better known, since these have been used in biological control of insect pests. Some Cordyceps species are sources of biochemicals with interesting biological and pharmacological properties,[7] like cordycepin; the anamorph of Cordyceps subsessilis (Tolypocladium inflatum) was the source of ciclosporina drug helpful in human organ transplants, as it suppresses the immune system (Immunosuppressive drug).[8]

Contents
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1 Medicinal importance 2 Ma Junren case 3 Value 4 Gallery 5 See also 6 References 7 Further reading 8 External links

[edit] Medicinal importance

Cordyce

The C

medi ine, Cordyceps have been used to treat several conditions including cancers for thousand of years. Extracts from both mycelium and fruiting bodies of C. sinensis, C. militaris and other Cordyceps species showed significant anticancer activities by various mechanisms such as, modulating immune system and inducing cell apoptosis. Some polysaccharide components and cordycepin (3'-deoxyadenosine) have been isolated from C. sinensis and C. militaris, which acted as potent anticancer components.[9] Some work has been published in which C C
         

marrow and digestive systems of mice from whole body irradiation.[10] An experiment noted i i may protect the liver from damage.[11] An experiment with mice noted the mushroom may have an anti-depressant effect.[12] Researchers have noted that Cordyceps has
[13][14][15][16][17] a hypoglycemic effect and may be beneficial for people with insulin resistance.

[edi

Ma Junren, the coach of a group of female Chinese athletes who broke five world records in distance running in 1993 at the National Games in Beijing, China, told reporters that the runners were taking C at a single track event caused much attention and suspicion of drug use, and th records are e still widely regarded as dubious, as the athletes failed to match these performances outside of China at independently drug tested events.
 

[edi Value
According to Daniel inkler, the price of Cordyceps sinensis has risen dramatically on the Tibetan Plateau, basically 900% between 1998 and 2008, an annu average of over 20%. al However, the value of big-sized caterpillar fungus has increased more dramatically than smaller size Cordyceps, regarded as lower quality.[19]
! ! !
Year % Pri e in rease Pri e/kg (Yuan)

a compound isolated from the "Caterpillar fungus".

eps mushrooms have a long history as medi inal fungi In traditional Chinese

i has been used to protect the bone

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at his request.[18]. The number of new world records being set

1980s 1997 467% (incl. inflation) 2004 429% (incl. inflation) 2005

1,800 8,400 36,000 10,000 60,000

According to Modern Marvels, a show on the History Channel, mushroom hunters in Nepal can earn 900 dollars for an ounce of cordyceps.[1] The high value of cordyceps was evidently the reason it was one of only two Chinese traditional medicines to be stolen in a bra en theft in British Columbia. The stolen cordyceps has been estimated to have been worth Can $38,000.[20]

[edit] Gallery

Cordyceps sinensis (caterpillar fungus), mostly whole dried choice specimens.

Cordyceps beginning its growth from an insect.

Cordyceps militaris

ilit i

Cordyceps being weighed in at the market in China.

Chinese soup of silkie, seahorse and cordyceps.

[edi See also

Fungi portal

[edi References
1. ^ Holliday, John; Cleaver, Matt; (2008)."Medicinal Value of the Caterpillar Fungi Species of the Genus Cordyceps (Fr.) Link (Ascomycetes). A Review" (PDF). Internationa Journa of Medicina Mushrooms (New York: Begell House) 10 (3): 219. doi:10.1615/IntJMedMushr.v10.i3.30. ISSN 1521-9437. http://www.alohamedicinals.com/cordycepsIJM1003.pdf. ^ Winkler, D. 2008a. Yartsa Gunbu (Cordyceps sinensis) and the Fungal Commodification of the Rural Economy in Tibet AR. EconomicBotany 63.2: 291 306 ^ Halpern, Georges M. (2007). Healing Mushrooms. Square One Publishers. pp. 65 86. ISBN 978-07570-0196-3. http://www.alohamedicinals.com/HealingMush_Private_10 -18-06.pdf.

2. 3.

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Medicinal mushrooms Caterpillar fungus Yarchagumba (Caterpillar fungus Tochukaso, Dong Chong Xia Cao) Cordyceps information from Drugs.com. Med na Mush ooms: Their Therapeutic Properties and Current Medica Usage with Specia Emphasis on Cancer Treatments by Cancer Research U (the American equivalent to the US National Cancer Institute), 2001.[2]

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[edit] F rther reading

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^ "Neurophilosophy: Brain ashed by a parasite". 2006-11-20. http://neurophilosophy. ordpress.com/2006/11/20/brain ashed-by-a-parasite/. Retrieved 2008-0702. ^ Hughes, D. P.; Wappler, T.; Labandeira, C. C. (2010). "Ancient death-grip leaf scars reveal ant-fungal parasitism". Biology Letters 7 (1): 67 70. doi:10.1098/rsbl.2010.0521. PMID 20719770. edit ^ Sung, Gi-Ho; Nigel L. Hy el -Jones, Jae-Mo Sung, J. Jennifer Luangsa-ard, Bhushan Shrestha and Joseph W. Spatafora (2007). "Phylogenetic classification of Cordyceps and the clavicipitaceous fungi". Stud Mycol 57 (1): 5 59. doi:10.3114/sim.2007.57.01. PMC 2104736. PMID 18490993. http:// .pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2104736. ^ Holliday, John; Cleaver, Phillip; Lomis-Po ers, Megan; Patel, Dinesh; (2004). "Analysis of Quality and Techni ues for Hybridization of Medicinal Fungus Cordyceps sinensis (Berk.)Sacc. (Ascomycetes)" (PDF). International Journal o Medicinal Mushroo s (Ne York: Begell House) 6 (2): 152. ISSN 15219437. http:// .alohamedicinals.com/cordy_IJMM_hybrid_article.pdf. ^ Holliday, John (2005). "Cordyceps". In Coates, Paul M. (PDF). Encyclopedia o Dietary Supple ents. 1. Marcel Dekker. pp. 4 of Cordyceps Chapter. http:// .alohamedicinals.com/cordyceps.pdf. ^ Khan MA, Tania M, Zhang D, Chen H (May 2010). "Cordyceps Mushroom: A Potent Anticancer Nutraceutical". The Open Nutraceuticals Journal 3: 179 183. http:// .bentham.org/open/tonutraj/articles/V003/179TONUTRAJ.pdf. ^ Liu, Wei-Chung; Wang, Shu-Chi; Tsai, Min-Lung; Chen, Meng-Chi; Wang, Ya-Chen; Hong, Ji-Hong; McBride, William H.; Chiang, CS (2006-12). "Protection against Radiation-Induced Bone Marro and Intestinal Injuries by Cordyceps sinensis, a Chinese Herbal Medicine". Radiation Research 166 (6): 900 907. doi:10.1667/RR0670.1. PMID 17149981. ^ Ko WS, Hsu SL, Chyau CC, Chen KC, Peng RY (July 2009). "Compound Cordyceps TCM-700C exhibits potent hepatoprotective capability in animal model". Fitoterapia 81 (1): 1 7. doi:10.1016/j.fitote.2009.06.018. PMID 19596425. ^ Nishiza a K, Torii K, Ka asaki A, et al. (September 2007). "Antidepressant-like effect of Cordyceps sinensis in the mouse tail suspension test". Biol. Phar . Bull. 30 (9): 1758 1762. doi:10.1248/bpb.30.1758. PMID 17827735. ^ Kiho T, Hui J, Yamane A, Ukai S (December 1993). "Polysaccharides in fungi. XXXII. Hypoglycemic activity and chemical properties of a polysaccharide from the cultural mycelium of Cordyceps sinensis". Biol. Phar . Bull. 16 (12): 1291 1293. PMID 8130781. ^ Kiho T, Yamane A, Hui J, Usui S, Ukai S (February 1996). "Polysaccharides in fungi. XXXVI. Hypoglycemic activity of a polysaccharide (CS-F30) from the cultural mycelium of Cordyceps sinensis and its effect on glucose metabolism in mouse liver". Biol. Phar . Bull. 19 (2): 294 296. PMID 8850325. ^ Zhao CS, Yin WT, Wang JY, et al. (June 2002). "CordyMax Cs-4 improves glucose metabolism and increases insulin sensitivity in normal rats". J Altern Co ple ent Med 8 (3): 309 314. doi:10.1089/10755530260127998. PMID 12165188. ^ Lo HC, Tu ST, Lin KC, Lin SC (April 2004). "The anti-hyperglycemic activity of the fruiting body of Cordyceps in diabetic rats induced by nicotinamide and streptozotocin". Li e Sci. 74 (23): 2897 2908. doi:10.1016/j.lfs.2003.11.003. PMID 15050427. ^ Li SP, Zhang GH, Zeng Q, et al. (June 2006). "Hypoglycemic activity of polysaccharide, ith antioxidation, isolated from cultured Cordyceps mycelia". Phyto e dicine 13 (6): 428 433. doi:10.1016/j.phymed.2005.02.002. PMID 16716913. ^ Mackay, Duncan (2001-07-24). "Ma's army on the march again". The Guardian. http:// .guardian.co.uk/sport/2001/jul/24/athletics.duncanmackay1. Retrieved 2010-12-04. ^ Winkler, Daniel (2008). "Yarsa Gunbu (Cordyceps sinensis) and the Fungal Commodification of the Rural Economy in Nepal". Econo ic Botany 62 (3): 291 305. doi:10.1007/s12231-008-9038-3 (inactive 2010-01-07). ^ O sianik, Jenna (2010-07-14). "Bird's nests, fungus stolen in high-end B.C. heist.". Ctvbc.ca. http:// .ctvbc.ctv.ca/servlet/an/local/CTVNe s/20100714/bc_herbal_robbery_100714/20100714 ?hub=BritishColumbiaHome. Retrieved 2010-12-04.

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Bensky, D.; Gamble, A.; Clavey, S.; Stoger, E.; Lai Bensky, L. (2004). Chinese Herbal Medicine: Materia Medica (3rd ed.). Seattle: Eastland Press. ISBN 0-939616-42-4. Kobayasi, Y. (1941). "The genus Cordyceps and its allies". Science Reports o the Tokyo Bunrika Daigaku, Sect. B 5: 53 260. ISSN 0371-3547. Mains, E. B. (1957). "Species of Cordyceps parasitic on Elapho yces". Bulletin o the Torrey Botanical Club 84 (4): 243 251. doi:10.2307/2482671. ISSN 0040-9618. http://jstor.org/stable/2482671. Mains, E. B. (1958). "North American entomogenous species of Cordyceps". Mycologia 50 (2): 169 222. doi:10.2307/3756193. ISSN 0027-5514. http://jstor.org/stable/3756193. Tzean, S. S.; Hsieh, L. S.; Wu, W. J. (1997). Atlas o ento opathogenic ungi ro Taiwan. Tai an: Council of Agriculture, Executive Yuan. Paterson, R. R. M. (2008). "Cordyceps - a traditional Chinese medicine and another fungal therapeutic biofactory?". Phytoche istry 69 (7): 1469 1495. doi:10.1016/j.phytochem.2008.01.027. PMID 18343466.

[edit] External links

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Photos of Cordyceps fungi Independent Medicinal Research on Cordyceps Clinical Potential of C. sinensis by J. Ho ard Fun Facts about Cordyceps L'or brun du Tibet 2008 TV5 documentary coverage of Cordyceps BBC Planet Earth documentary coverage of Cordyceps An Electronic Monograph of Cordyceps and Related Fungi Cordyceps sinensis in Tibet

Cordyceps: Cancer Support and Immune Modulation From an Ancient Chinese Herbal Medicine by Dr. Nalini Chilkov on April 27, 2011 6Share

Image via Wikipedia

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Cordyceps sinensis (CS), a traditional Chinese Medicine is a fungus that has been historically used for over 2,000 years throughout China and Asia as part of treatment for a variety of conditions including many cancers. In modern times the effects of Cordyceps on immune modulation and its use in concert ith modern chemotherapy agents, both to enhance therapeutic benefit and to manage side effects have been idely studied. Cordycepin, one of the active constituents, has been sho n to possess many pharmacological activities including immunological stimulation, and anti-bacterial, anti-viral, anti-oxidant anti-inflammatory and anti-tumor effects. It may be of benefit to support cancer patients and cancer survivors. Available evidence suggests that the efficacy of CS as a potential anti-neoplastic/anti cancer therapeutic agent is related to a role as an activator of innate immune responses. Cordyceps, like many other medicinal mushrooms has been traditionally cooked into soups in Asia for its nutritive and tonic properties. Like other medicinal mushrooms CS is rich in polysaccharides, the primary immune modulators as ell as being rich in vitamins and minerals. It can be thought of as a medicinal food.Cordyceps is best taken as either a ater extract (tea or soup) or a high uality po der can be mixed into juice or ater, or even into yoghurt or applesauce. It is important to get high uality, properly prepared and processed Cordyceps product to insure that you ill get the most benefit from this healing mushroom. As ith any other product of this nature, seek the guidance of a health care professional. The constituents in medicinal mushrooms such as CS have fe drug interactions and can often be used safely along ith conventional therapies. Al ays discuss the use of herbal medicines ith your doctor. What are the potential benefits of Cordyceps sinensis? Studies sho the follo ing actions and effects of the ater extract of Cordyceps sinensis: (CS): The polysaccharides in CS have been sho n to have immune stimulating and anti tumor activity. CS had been sho n to inhibit the gro th of several cancer cell lines CS has also been sho n to protect the liver and kidneys from toxic side effects of chemotherapy. CS has been sho n to potentiate and enhance the activity of some chemotherapy drugs. CS has been sho n to promote Cell Death (induce apoptosis). Normal cells ill self destruct (undergo apoptosis) hen the cell is damaged. Cancer cells fail to do so. Agents hich cause normal cell death are used idely in chemotherapy today. CS has been sho n to induce apoptosis or normal cell death in cancer cells in many studies and suggests that CS might be a valuable adjunct therapy for cancer patients. CS is a potent antioxidant, thus protecting cells from free radical damage. Free radical damage is a process in hich free electrons damage our cells and our DNA. Free radical damage is thought to be a primary factor in the aging process. Additionally hen DNA (genetic material) in the cells is damaged, risk of cancer increases. CS has been sho n to enhance the production of Glutathione and SOD, protective, natural antioxidants produced in our cells to protect against free radical damage and oxidation.

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CS demonstrates anti-inflammatory properties. Inflammation is a factor common to many diseases, including cancer. Supporting the management of inflammation modulates our immune system. In particular, CS has been sho n to suppress the production of COX-2, NFkB and TNFa, inflammatory molecules present in cancer cells and many other disease processes. CS has been sho n to increase the production of Natural Killer (NK) cells. NK cells are primary protective cell in our natural innate immune response is active against both tumor cells and viral cells. CS has also been sho n to inhibit metastasis and the spread of some cancers. It is metastasis, the spread of cancer cells from the primary original site of the tumor to other parts of the body that causes cancer patients to die. Inhibiting metastasis therefore prolong life for cancer patients. Some studies have sho n that CS prevents metastasis by inhibiting angiogenesis, the process by hich tumor cells make ne blood vessels, allo ing tumors to gro in size as ell as allo ing cancer cells to enter the blood stream and travel to other parts of the body. Qualitatively cancer patients using CS along ith their chemotherapy report less fatigue, reduced pain and less eight loss during treatment. CS has also demonstrated anti-viral and antibacterial properties. Cancer patients are often at risk for infection during chemotherapy and after surgery. Researchers hypothesize that CS increases resistance to infections by modulating immune function, increasing hite blood cells and Natural Killer cells and by modulating inflammation. Additionally, CS has been sho n to protect against bone loss and osteoporosis, a risk factor for many patients, especially breast cancer and prostate cancer patients on medications hich block hormones. These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease. Al ays consult your doctor before using any supplement or herb. Primary References (additional references available) 1. Cancer Immunol Immunother. 2010 May;59(5):789-97. Epub 2009 Dec 3. Activation of innate immunity to reduce lung metastases in breast cancer. Jordan JL, No ak A, Lee TD. Department of Pathology, Atlantic Centre for Transplantation Research, Dalhousie University, Halifax, Canada. julie.jordan@dal.ca 2. Immunopharmacol Immunotoxicol. 2008;30(1):53-70. Immune activation by a sterile a ueous extract of Cordyceps sinensis: mechanism of action. Jordan JL, Sullivan AM, Lee TD. Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada.

3. Polysaccharide of Cordyceps sinensis Enhances Cisplatin Cytotoxicity in Non-Small Cell Lung Cancer H157 Cell Line. Ji NF, Yao LS, Li Y, He W, Yi KS, Huang M. Integr Cancer Ther. 2011 Mar 7. [Epub ahead of print] PMID: 21382957 [PubMed - as supplied by publisher] RESULTS: Compared ith the cells treated ith cisplatin alone, cell viability as significantly decreased and the expression levels of VEGF and bFGF protein ere significantly reduced in the ce lls treated ith a combination of CS and cisplatin. CONCLUSION: The current study indicates that the polysaccharide of CS inhibits tumor gro th in NSCLC and that CS may be a potential adjuvant chemotherapeutic agent in NSCLC therapy. 4. Biotechnol Appl Biochem. 2005 Aug;42(Pt 1):9-15. Immunomodulatory and antitumour effects of an exopolysaccharide fraction from cultivated Cordyceps sinensis (Chinese caterpillar fungus) on tumour-bearing mice.Zhang W, Yang J, Chen J, Hou Y, Han X. Immunology and Reproductive Biology Laboratory, Medical School, Nanjing University, Nanjing, 210093, People s Republic of China. zhang y@nju.edu.cn 5. Exp Biol Med (May ood). 2008 Apr;233(4):447-55. Cordyceps sinensis health supplement enhances recovery from taxol induced leukopenia. Liu WC, Chuang WL, Tsai ML, Hong JH, McBride WH, Chiang CS. The Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 101 Sec. 2, Kuang-Fu Road, Hsinchu 30013, Tai an. In summary, CS enhances recovery of mice from leukopenia caused by Taxol treatment. It appears to do so by protecting both hematopoietic progenitor cells directly and the bone marro stem cell niche through its effects on osteoblast differentiation. 6. Biofactors. 2007;30(2):105-16. Water extract of Cordyceps sinensis (WECS) inhibits the RANKL-induced osteoclast differentiation.Mizuha Y, Yamamoto H, Sato T, Tsuji M, Masuda M, Uchida M, Sakai K, Taketani Y, Yasutomo K, Sasaki H, Takeda E. Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto-cho, Tokushima, Japan. 7. Cordycepin suppresses TNF-alpha-induced invasion, migration and matrix metalloproteinase-9 expression in human bladder cancer cell Eo-Jin Lee, Wun-Jae Kim. Sung-Kwon Moon. Article first published online: 17 JUN 2010 DOI: 10.1002/ptr.3132 Phytotherapy Research Volume 24, Issue 12, pages 1755 1761, December 2010 8. RNA-directed agent, cordycepin, induces cell death in multiple myeloma cells BRITISH JOURNAL OF HAEMATOLOGY Volume 140, Issue 6, March 2008, Pages: 682 391, Lisa S. Chen, Christine M. Stellrecht and Varsha Gandhi

Article first published online : 18 JAN 2008, DOI: 10.1111/j.1365-2141.2007.06955. 9. CORDYCEPIN AND CORDYCEPS SINENSIS REDUCE THE GROWTH OF HUMAN PROMYELOCYTIC LEUKAEMIA CELLS THROUGH THE Wnt SIGNALLING PATHWAY CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY Volume 34November 2007, Pages: S61 S63, Noriko Yoshikawa, Kazuki Nakamura, Yu Yamaguchi, Satomi Kagota, Kazumasa Shinozuka and Masaru Kunitomo Article first published online : 30 OCT 2007, DOI: 10.1111/j.1440-1681.2007.04781.x 10. Toxicol In Vitro. 2011 Feb 15. [Epub ahead of print] Induction of apoptosis by cordycepin via reactive oxygen species generation in human leukemia cells.Jeong JW, Jin CY, Park C, Hong SH, Kim GY, Jeong YK, Lee JD, Yoo YH, Choi YH. Department of Biochemistry and Research Institute of Oriental Medicine, Dongeui University College of Oriental Medicine, Busan 614-052, Republic of Korea; Department of Microbiology, College of Natural Sciences, Pusan National University, Busan 609-735, Republic of Korea. 11. Li SP; Li P; Dong TT; Tsim KW Anti-oxidation activity of different types of natural Cordyceps sinensis and cultured Cordyceps mycelia. Phytomedicine 2001 May;8(3):207 (ISSN: 0944-12 7113) Department of Biology and Biotechnology Research Institute, The Hong Kong University of Science and Technology, China. 12. Shin KH; Lim SS; Lee SH; Lee YS; Cho SY, Antioxidant and immunostimulating activities of the fruiting bodies of Paecilomyces japonica, a new type of Cordyceps sp. Ann N Y Acad Sci 2001 Apr;928:261-73 (ISSN: 0077-8923) Natural Products Research Institute, Seoul National University, Korea. khshin@plaza.snu.ac.kr. 13. Shin KH, Lim SS, Lee S, Lee YS, Jung SH, Cho SY., Anti-tumor and immuno-stimulating activities of the fruiting bodies of Paecilomyces japonica, a new type of Cordyceps spp. Phytother Res. 2003 Aug;17(7):830-3. Natural Products Research Institute, Seoul National University, Seoul, Korea. khshin@snu.ac.kr 14. Jordan JL, Sullivan AM, Lee TD. Immune activation by a sterile a ueous extract of Cordyceps sinensis: mechanism of action. Immunopharmacol Immunotoxicol. 2008;30(1):53-70.

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