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PAPER NAME : MINOR 2

1) Select the ornithine derived alkalods

A) Tropane & Muscarine

B) Ephedrine & tropane

C) Tropane only

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D) All of these

Correct Answer is A

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EXP : Tropane alkaloids are ornithine derived & contain plant belladona,stramonium,hyoscyamus etc

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2) Ontogenesis is defines as

A) Change in amount of principal chemical constituent in plant due to variation in age, enviormental

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effect etc

B) Change in amount of all chemical constituent in plant due to variation in age, enviormental effect etc

C) Change in macroscopic characters of a plant due to enviourmental effects

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D) Change in microscopic characters of a plant due to enviourmental effects
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Correct Answer is A

EXP : Change in amount of principal chemical constituent in plant due to variation in age,
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enviormental effect etc. Eg: Change in tropane alkaloids in stramonium due to age (youn & flowering)

3) Microscopically, Ephedra sinica can be distinguised from E.equisetina by

.b

A) Lignified pith

B) Unlignified pith
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C) Flowers
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D) Internode

Correct Answer is A
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EXP : E.sinica show lignified pith & highest length of internode (3-6 cm) as compared with other
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species:E.equisetina & E.distachya

4) Select the best microscopic distinguish character of Lobelia

A) Casperian strips

B) Stone cells

C) Sandy crystals

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D) All of these

Correct Answer is A

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5) For maximum phytoconstituents recovery, The drug "Ephedra" can be best collected in the months

f.c
of

A) Autumn

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B) Summer

C) Winter m
D) Whole year

Correct Answer is
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EXP : Collection must be in autumn only as the amount of alkaloids shows considerable variation at
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different seasons ()

6) Select the correct set of alkaloids derived from Tryptophen

A) Vincristin,Tropane,Reserpine & Ergotamine

.b

B) Vincristin,Tropane,Morphine & Ergotamine

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C) Vincristin,Tropane,Morphine & Quinine

D) Vincristin,Brucin,Reserpine & Ergotamine

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Correct Answer is D
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EXP : Generally all indole alkaloids are derived from tryptophen.

7) Select the proto-alkaloid

A) Muscaline
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B) Caffine

C) Emetine

D) All of these

Correct Answer is A

EXP : Proto-alkaloids are amines without hetrocyclic ring

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8) Select the alkaloid present as a recemate

A) Atropine

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B) Hyoscymine

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C) Hyoscine

D) All of these

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Correct Answer is A

EXP : Atropine is a recemic mixture of hyoscymine. m

9) The enzyme, Agerobacterium rhizogenes transformed________culture of Lobelia inflata prodce

lobeline at the same concentration as normal pot-grown plants

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A) Root
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B) Shoot

C) Tissue

D) Internode
.b

Correct Answer is A
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10) Thalleiquin test (A chemical test for alkaloids) is rational for

A) Cupreine
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B) Quinidine
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C) Quinine

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D) All of these

Correct Answer is D

11) Select the chemotaxonomic marker of the family Solanaceae

A) Ornithine

B) Tropane

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C) Methylated Traopane

D) Choliec acid

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Correct Answer is C

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12) Black peeper contains

A) Lysin derived alkaloids

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B) Ornithin derived alkaloids

C) Tryptophen derived alkaloid m

D) Benzyl-isoquinaline alkaloid

Correct Answer is A
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EXP : Lysine derived alkaloids are present in:Lycopodium,Black peeper, lobelia etc.
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13) Select the wrong statement for gram s staining

A) Differentiate bacterial species based on the physical properties of their cell wall

B) During the staining, for rapid decolorization alcohol or acetone is used

.b

C) Crystal violet ion interacts with negatively charged components of bacterial cells
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D) Iodine solution acts as a primary stain

Correct Answer is D
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14) Structurally Estradiol differs from Testosterone by

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A) Presence of 2 Carbonyl group

B) Presence of 2 hydroxyl group

C) Presence of 3 hydroxyl group

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D) Absence of hydroxyl group

Correct Answer is B

15) Name the mode by which Vitamin D is metabolized

A) Decarboxylation

B) Methyation

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C) ransesterification

D) Hydroxylation

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Correct Answer is D

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16) Inclusion of 9 alpha fluoro substituent in steroidal nucleus

A) ncreases only Glucocorticoid activty

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B) Increases both Glucocorticoid and Mineralocorticoid activity

C) Increases only Mineralocorticoid activty m

D) Decreases both Glucocorticoid and Mineralocorticoid Activity

Correct Answer is B
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17) Which is the 1- dehydroderivative of cortisone
ph

A) Prednisone

B) Prednisolone

C) Fluadrenlone
.b

D) Fluprednisolone
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Correct Answer is A

18) Name the metabolic product of progesterone which can be used as an index of corpus luteum
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A) 5 beta-pregnanediol glucouronide
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B) 5 alpha- pregnanediol glucouronide

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C) 17 alpha-hydroxy progesterone

D) 17 beta-hydroxy progesterone

Correct Answer is A

19) Find the six monthly injectable hormonal preparation

A) Depot medroxy progesterone acetate

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B) 17 a-hydroxy progesterone caproate

C) Lynestrenol phenyl propionate

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D) Norethisterone Oenanthate

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Correct Answer is A

20) Select the wrong statement for Retention factor (Rf) value in chromatographic techniques

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A) Can be used for the Characterization of samples

B) Constant for a sample in a selected mobile phase m

C) Constant for a sample in all mobile phase

D) None of these
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Correct Answer is C
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21) Gas chromatography is good for the compounds which

A) Should Vaporized with decomposition

B) Should Vaporized without decomposition

.b

C) Should not vaporized

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D) Should be always polar

Correct Answer is B
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22) In HPTLC
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A) Polar stationary & Non polar mobile phase

B) Nonpolar stationary & polar mobile phase

C) Both should be polar

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D) Both should be non-polar

Correct Answer is A

EXP : Polar compounds retained because of higher affinity with the stationary phas

23) Pharmacogenomics is the branch of Pharmacology that deals with

A) Study of drug effects at the population level

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B) Genetic influences on responses of drugs

C) Study of ADME of drugs i.e what body do to the drugs

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D) Science that use genetic information to guide the choice of drug therapy to individual or others

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Correct Answer is D

24) The effect of a drug gradually diminishes when it is given continuously or repeatedly. Which of the

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following is true

A) Desensitisation is term used to describe this phenomenon

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B) Tachyphylaxis is term used to describe this phenomenon

C) Drug resistance is term used to describe loss of effectiveness of antimicrobial and antitumor drugs.
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D) All of above
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Correct Answer is D

25) In dose response curve the Emax is the maximal response of the drug at a dose. ED50 is :

A) The response occurred in 50% of animal population

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B) The dose at which response occurs 50% of Emax.

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C) The dose at which 50% animals shows effect of the drug

D) ED 50 is not related with the dose of the drug

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Correct Answer is B
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26) Arsenic poisoning is treated primarily with one of the following drug

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A) Dimercaprol

B) EDTA (Ethylene Diamine Tetra Acetate)

C) Desferrioxamine Mesylate

D) Trientine

Correct Answer is A

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27) Dimercaprol acts by one of the following mechanism

A) Metal is complexed with SH (Sulphydryl) group

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B) Metal is complexed with OH group

f.c
C) Metal is complexed with -NH2 (Amino group) group

D) None of the above

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Correct Answer is A

EXP : Arsenic poisoning is treated primarily with Dimercaprol. It is also known as BAL (British
m
Anti-Leuisite). Dimercaprol having two SH group and arsenic and other metals binds with these groups

and form a complex and this complex excreted in urine. In addition to arsenic poisoning, dimercaprol is
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also used in treatment for gold, mercury also. Heavy metal poisoning related questions are more
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frequently asked in NIPER-JEE.

28) Which of the following is used in treatment Wilson s disease

A) BAL
.b

B) Penicillamine
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C) EDTA

D) Desferrioxamine
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Correct Answer is B
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EXP : Penicillamine is used for the removal od copper in hepatolenticular degeneration (Wilson s

disease). In this condition, copper is deposited in the tissue leading to hepatic cirrhosis and

extrapyramidal neuroloigical damage.

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29) Bioassay is a procedure for determining the

A) Quantitative relationship between the dose (or concentration) of a drug and magnitude of response

B) Qualitative relationship between the dose (or concentration) of a drug and magnitude of response

C) Qualitative relationship between the dose (or concentration) of a drug and duration of response

D) Quantitative relationship between the dose (or concentration) of a drug and duration of response

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Correct Answer is A

30) Which of the following drug can be bioassayed by Radioimmunoassay method?

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A) Paracetamol

f.c
B) Adrinamycin

C) Naproxen

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D) Nimusalide

Correct Answer is B m
EXP : Adrinamycin, carbamazapine and other drugs are assayed by this method ( list given on p 54 of

FSK BARAR Fourth edition. Remember the list)

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31) Lead poisoning is primarily treated with
ph

A) Dimercaprol

B) Calcium Di sodium edetate

C) Sodium thiosulphate
.b

D) BAL
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Correct Answer is B

EXP : Calcium Di sodium edentate is used primarily to treat Lead poisoning (plumbism). The chelated
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form is stable, water soluble and readily excreted by the kidneys.

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32) Which of the following is NOT correct pair in terms of heavy metal poisoning and the treatment:

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A) Copper- Penicillamine

B) Iron - Desferrioxamine

C) Lead- Dimercaprol

D) Arsenic-BAL

Correct Answer is C

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33) Cellulose membrane filters utilizes& ..

A) Surface filtration

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B) Depth filtration

f.c
C) Both a & b

D) None of these

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Correct Answer is A

34) Sensible heat flow from dry air to cool surface results in& .
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A) Humidification

B) Dehumidification
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C) Refrigration
ph

D) Adiabatic Saturation

Correct Answer is A

35) Working principle of Ball mill is based on& .

.b

A) Cutting & Impact

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B) Impact & Attrition

C) Impact only
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D) Attrition only
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Correct Answer is B

36) Non viscous liquids that don t deposit scales can be evaporated using& .

A) Horizontal tube evaporator

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B) Evaporating pans

C) Multiple effect evaporator

D) Any type of evaporator

Correct Answer is A

37) Which of the following is not used to measure the viscosity :

m
A) Falling sphere viscometer

B) Capillary viscometer

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C) Cup and Bob viscometer

f.c
D) All are used

Correct Answer is D

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38) Select the irrational statement for Filter Aids& .

A) Recoverable m
B) Porous rather than dense

C) Low specific gravity

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D) Dense rather than porous
ph

Correct Answer is D

39) Filter leaf is applicable for& .

A) Diluted suspensions
.b

B) Concentrated suspensions
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C) Both a & b

D) None of these
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Correct Answer is A
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40) Cartridge filters contains& ..

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A) One prefilter & one actual filter made up of polypropylene

B) One prefilter made up of polypropylene

C) One prefilter & one actual filter made up of polyethylene

D) Two actual filter made up of polypropylene

Correct Answer is A

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41) Screeneeing of very diluted (approx 1%w/v) colloidal suspension is known as& .

A) Clarification

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B) Filtration

f.c
C) Expression

D) Colation

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Correct Answer is A

42) Which of the following theory is associated with crystal growth:

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A) Griffin

B) Ficks theory
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C) Noyes Whitney equation
ph

D) Ostwald ripining

Correct Answer is D

43) Reynold s no is associated with

.b

A) Fluid viscosity
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B) Solid content in fluid

C) Flow of fluid
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D) All of above
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Correct Answer is C

44) 0.1% dispersion of HPMC in water will follow:

A) Plastic flow
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B) Dilatant flow

C) Newtonian flow

D) Pseudoplastic flow

Correct Answer is C

45) The driving force of crystallisation is

m
A) Supersaturation

B) Concentration gradient

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C) Tempreture variation

f.c
D) Pressure diffrence

Correct Answer is A

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EXP : Supersaturation is the driving force of the crystallization, as the rate of nucleation and growth is

driven by the existing supersaturation in the solution.m

46) Which will result in crystallisation

A) Supersaturation
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B) Use of antisolvent
ph

C) Solution cooling

D) All of these

Correct Answer is D
.b

EXP : Crystallisation can be achieved by various methods, with (1) solution cooling, (2) addition of a
w

second solvent to reduce the solubility of the solute (technique known as antisolvent or drown-out), (3)

chemical reaction and (4) change in pH being the most common methods used in industrial practice.
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47) Laminar flow is the result of (Reynold s no:R)

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A) R

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B) R

C) R=2300

D) R=4000

Correct Answer is A

EXP : For flow in a pipe of diameter D, experimental observations show that for 'fully developed' flow

m
(Note:[12]), laminar flow occurs when ReD 4000

48) Select the wrong statement for phenolcofficient

o
A) Measure of bactericidal activity

f.c
B) May be determined in the presence or absence of organic matter

C) Expressed in a numerical figure with respect to phenol as a standared

stu
D) None of these

Correct Answer is D m
EXP : Phenol coefficient is a measure of the bactericidal activity of a chemical compound in relation to

phenol. When listed numerically, the figure expressing the disinfecting power of a substance by relating
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it to the disinfecting power of phenol may be a function of the standardized test performed. To calculate
ph

phenol coefficient, the concentration of the test compound at which the compound kills the test

organism in 10 minutes, but not in 5 minutes, is divided by the concentration of phenol that kills the

organism under the same conditions. The phenol coefficient may be determined in the presence of a
.b

standard amount of added organic matter or in the absence of organic matter. and the formula is given
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by N=1/CT where C is the conc. of agent applied and T is the time for which agent is applied and N is

the number of survivors so N is inversely proportional to dose (CT is collectively called dose)
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49) Select the optimized operating condition for "Autoclave"

w

A) 121 C for 15-20 min at 15 lb/sq inch

B) 121 C for 15-20 min at 50 lb/sq inch

C) 171 C for 15-20 min at 15 lb/sq inch

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D) 151 C for 20-40 min at 15 lb/sq inch

Correct Answer is A

EXP : An autoclave is a device used to sterilize equipment and supplies by subjecting them to high

pressure saturated steam at 121 C or more, typically for 15 20 minutes depending on the size of the load

and the contents

m
50) Select a serological technique

A) ELISA

o
B) Agglutination

f.c
C) Coplement fixation

D) All of these

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Correct Answer is D

EXP : There are several serology techniques that can be used depending on the antibodies being
m
studied. These include: ELISA, agglutination, precipitation, complement-fixation, and fluorescent

antibodies.
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Page 10/10
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.b
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