Winchester, MA 01890 781-721-1598 en1c03e9@westpost.net DIRECTOR OF RESEARCH Preclinical Studies / INDs / FDA Cellular & Molecular Biology / HTS Project Management / Technology Assessment Automation / Publications / Presentations Startups / GPCR / Team Building A skilled cellular and molecular biology researcher, I drove new drug discoveries for industry-leading and startup pharmaceuticals, including Pfizer and Infinity Pharmaceuticals. I consistently collaborated with internal teams, scientists, academics and vendors to facilitate introduction of new candidates into clinical trials and filing of INDs. Adept at obtaining and applying cutting-edge technology to enhance preclinical efforts, I have expeditiously and cost-effectively conducted research leading to superior findings and results. I can contribute immediately by: * Utilizing advanced technology to develop breakthrough drug candidates * Establishing, training and leading effective multi-functional teams * Developing relationships and resources with industry and academic professionals * Working closely with marketing, legal and IP departments to foster publication * Explaining complex scientific theories to professionals and lay people While attending Paris University, I earned a Masters in Biochemistry, a Pharm. D. and a Ph.D. in Cellular and Molecular Biology. I hold six patents and I have received awards and grants from US and French institutions. I have also authored numerous publications and posters and presented at several international conferences. SELECTED ACCOMPLISHMENTS Spurred IND filings by initiating and leading collaboration. Seeking input from collaborators was not a high-priority at Infinity. Initiated fruitful interactions with many professional and academic opinion leaders. Built group to 50+ collaborators who shared proprietary tools and published drug activity data, facilitating new clinical studies. Spearheaded significant growth of drug- discovery projects. Infinity pipeline of new projects was not extensive. Enthusiastically researched, created and formally presented five new projects in front of entire company, with three obtaining funding. Quickly gained recognition as main initiator and provider of new projects. Introduced cutting edge technology to facilitate new clinical trials. Pfizer needed complex and costly machine to obtain real-time ion-flux information. Sourced different vendors and machines. Proposed and secured $500K screening equipment. Ran four campaigns leading to important drug discovery. Keyed discovery of promising new drug indication. Research of new indications for clinical candidate was not optimal. Initiated collaboration with Harvard Medical School professor to combine Infinity drug with another anti-cancer drug. Preliminary experiments provided spectacular results, leading to publication and possible clinical trials. Established strong publication/communication culture. Infinity project team lacked driving force to effectively communicate and publish its findings. Infused get finished and publish attitude. Fostered production of posters for presentation at key meetings and publication of reviews and scientific articles. Enhanced company image. Linked biology with automation to expedite HTS assay. Infinity assay for high throughput screening (HTS) campaign was time consuming. Redeveloped and automated assay with fewer steps. Accelerated campaign and brought hits for further evaluation. Collaboration between cell biologist and robotic engineer was key to success. CAREER HISTORY Associate Director of Research, Preclinical Studies, Infinity Pharmaceuticals, 2002- Present. Lead 15-member multi-disciplinary oncology research team responsible for new indications and combinations, mechanisms of action and resistance and Biomarkers for Phase I and II drugs. Ran PD analysis (Phase 1 and 2). Filed INDs and IRBs for several indications. Recruited as Senior Scientist in 2002 and promoted to Lead Senior Scientist in 2004. Senior Scientist, Pfizer Inc. 1998-2002. Managed target identification, assay development and HTS efforts in Inflammation, COPD, asthma and pain. Developed and ran assays (SPA, FP, FRET). Implemented and led Cell-based Assay Section (FLIPR, beta- lactamase assay). Project Director for screening program (GPCR). Fellow, N.I.H., 1995-1998. Postdoctoral fellowship at NICHD, section of Cellular Neurobiology.