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Formula: C26H29Cl2N5O3 N
N O N enquiry@selleckchem.com
Solubility: DMSO
Purity: 99%
O
HN
CN
O
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Storage: at -20℃ 2 years Cl Cl (chemistry support)
CAS No.: 380843-75-4 Synonyms: SKI-606 techbio@selleckchem.com
(bio support)
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Biological Activity
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The cellular Src (c-Src) protein is a nonreceptor tyrosine kinase normally maintained in an inactive
conformation via intramolecular interactions.[1] c-Src coordinates multiple signaling pathways
known to be involved in tumor progression, such as proliferation, survival, motility, angiogenesis,
cell-cell communication, adhesion, and invasion.[2,3] SKI-606 inhibited migration of breast cancer
cell lines with IC50 values of 0.1 to 0.3 umol/L; After a 48 h treatment with 1 Amol/L SKI-606,
all the invasioncompetent cell lines were unable to cross the porous membrane; cell proliferation
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and survival were unaffected by SKI-606 at concentrations sufficient to block cell migration and
invasion.
References
[1] Frame MC. Biochim Biophys Acta. 2002 Jun 21;1602(2):114-30 Return Policy
[2] Thomas SM, Brugge JS. Annu Rev Cell Dev Biol. 1997;13:513-609 Please inspect packages immediately upon
Please visit www.selleckchem.com to download MSDS and CoA. for return if made within 3 days of delivery,
restocking charge.
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. For all product returns and product replace-