Professional Documents
Culture Documents
8. Examination questions
8.1. Human anatomy
1. Relationship between the structure and function of the intestine wall layers.
2. Structural components of the gastric mucosa and submucosal layer, and their structural
relationship with the function of stomach.
3. Characterization of liver intraorganic blood circulation.
4. Structural and functional features of the bile ducts.
5. Structural components of the exocrine pancreas.
8.2. Physiology
1. Factors affecting secretion of hydrochloric acid in the stomach. Mechanisms of their action.
2. Phases of gastric juice secretion and their features.
3. Nervous and humoral regulation of secretion of pancreatic juice and bile.
4. Regulation of functions of small and large intestine. Defecation.
8.7. Biochemistry
1. Digestion of polysaccharides, absorption of products of digestion.
2. Digestion of lipids (TAG, phospholipids, cholestrol esters), absorption of products of
digestion.
3. Digestion of proteins, absorption of products of digestion.
4. Biosynthesis of hydrochloric acid in the stomach and its functions. Determination of
acidity of gastric juice.
5. Structure of bile acids, role of bile in nutrient digestion.
6. Metabolism of hemoproteins. Bile pigments and their metabolism.
7. Reaction sequence of glycogen breakdown, enzymes, regulation, energy value,
physiological significance.
8. Reaction sequence of glycogen synthesis, enzymes, regulation, physiological
significance.
9. Metabolism of acetyl-CoA produced in beta-oxidation; ketogenesis (production of
ketone bodies): substrates, reaction, enzymes, products, transportation and consumption of
keton bodies.
10. Synthesis of triacylglycerols in tissues (tissue lipolysis) and its regulation.
11. Breakdown of triacylglycerols in tissues (tissue lipolysis) and its regulation.
12. Biological significance of cholesterol. Origin of cholesterol in human organism. The
main stages of cholesterol synthesis. Regulation of cholesterol synthesis.
13. Approximate composition of chylomicrons, chylomicron formation and metabolism.
14. Approximate composition of very low density lipoproteins (VLDL), VLDL formation
and metabolism.
15. Approximate composition of high density lipoproteins (HDL). HDL formation and
metabolism.
16. General pathways of amino acid synthesis. Deamination of amino acids: ways of
deamination, enzymes, their specificity, coenzymes, products and their metabolism. Diagnostic
significance of aminotransferases.
17. Formation of ammonia and its detoxication in human organism.
18. Metabolism and elimination of xenobiotics.
19. Metabolism of ethanol. Mechanisms of ethanol toxicity.
20. Synthesis of insulin, secretion and its regulation in human organism. Target cells of
insulin. Structure of insulin receptors, mechanism of intracellular signal transduction.
Physiological effects of insulin.
21. Synthesis of glucagon, secretion and its regulation in human organism. Target cells of
glucagons. Location of glucagons receptors, mechanism of intracellular signal transduction.
Physiological effects of glucagon.
22. Mechanisms of regulation of glucose concentration in blood: implication of glucagon,
glucocorticoids and insulin.
8.8 Pharmacology
1. Insulin preparations: classification (by origin and duration of action), relationship between
pharmacokinetic properties and timing of administration.
2. Short-acting insulin preparations.
3. Intermediate-acting and long-acting insulin preparations.
4. Sulfonylureas and meglitinides.
5. Biguanides.
6. Thiazolidinediones and alpha-glucosidase inhibitors.
7. Undesirable effects of medicines used for the treatment of diabetes mellitus. Medicines used
for the treatment of hypoglycemia.
8. Medicines used for the treatment of dyslipidemia: classification, mechanisms of action.
9. Statins: mechanism of action, indications, undesirable effects.
10. Undesirable effects of medicines used for the treatment of dyslipidemia.