:‫كل الشكر والتقدير لكل من‬

‫** عالية تكروني * عايشة خلفان‬ ‫حميدة كاظم‬ * ‫إيناس الشارخ * حصة الجري‬ * ‫آالء بــــاعـــارمــــــه* أفراح بابلي‬
* ‫* فوزية الشمراني‬
‫شروق الخليفة * منى الفرج‬

:GIT
: Not used as antiemitic due to cytotoxic drugs -1
a- cyclizin . b- ondansteron . c- nabilone . d- metoclopramide
.coz its work in H1 receptors which cause vomiting due to motion sickness only *
Mismatch of the ttt of ulcer : Al (OH) :diarrhea -2
. Bulk luxtives :methylcellulose -3
Not true about omeprazole : Used alone to ttt H.pyori -4
: Antibiotic that used to ttt H.pylori -5
. a- cimitidine . b- Mg salt . c- bismuth . d- sacralfate
: Not antidirrheal drugs -6
.a- clonidine . b- lactalose . c-kaloine . d- diphnoxlate
: Not act in CTZ -7
a- domprdone . b- metoclopramide . c- ondansterone . d- scopolamine
Prokinitic & antiemitic : dompridone -8

: Endocrine
: the ttt of DM ketoacidosis -1
Give IV insulin to correct the hyperglycemia & hyperkalemia
CI with estrogen contraceptive : Breast cancer -2
.Not a mechanisms of progesterone as acontraceptive : (-) ovarian follicles -3
Not used to ttt osteoperosis : Anastrazole -4
. Not a function of corticosteroids : uric acid execretions -5
not a long action corticosteroids : cortisole ( cortisone or hydrocortisone ) -6
Mismatch in oral hypoglycemic drugs : glitazone (- ) aldose enzyme -7
. Finastride action : (-) alpha reductase enzyme -8
: Mismatch in thr ttt of hyperthyroidism -9
Radioactive I causes : relapse hyperthyroidism

. Not true about ADH : Its secreted by adenohypophysis -10

Not true about V2 (ADH) : involved Phospholipase C -11
Not true for calctriol : it’s a procusure of Vit D -12
Not true for Effects of insulin in the muscle : ( - ) lipoprotein lipase -13
. For peptides, all are true except : They bind to globulin -14
: The benifite of using cosyntropin over the ACTH -15
less sensitivity reactions
We use lupron coz its : ttt the infertility -16
! ‫ بس السؤال سهل‬، ‫ ما افتكر إذا كان هذا هو الجواب وال ال‬، ‫معليش جاني فقدان ذاكرة‬
: The ttt of SIADH -17
a- nicotine . b- depression . c- NSAIDs. d- V2 antagonit

Mismatch : a- Bromocribten : decrease prolactin . b- cabrogolin : (-) FSH&LH -18

: Not Tocolytic ( causes diltation of the uterus ) -19
a- indomethacine . b- atosipan . c- misopristole . d- ritodrine
: ADR of anapolic steroids -20
.a- muscle weakness. b- hypertrophy of the testes .c- osteoperosis . d- coronary artery
: Cortisole (-) all these genes , except -21
a- Cox2. b- Igs . c- Annexin1. d- No synthtase
. : Not true about Ca & drugs interactions -22
. a- cortisole : decreases Ca level . b- Thiazide : decrease the hypercalcimic effect
..c- Phynotin : decrease the metabolism of ca. d- Cholysteramine : decrease Ca

: Not a function of bisphosphnate -23

. a- (-) the recruitment of osteoclast . b- (-) the osteoclasts' apoptosis
. c- direct (+ ) osteoblast
: For glucocorticoids : ( Mismatch ) -24
. spronolactone : aldesterone agonist
: Mismatch of thyroid hormone -25
. T3 present in the circulation mainly
Mismatch in the ttt of hyperthirodism -26
a- I 131 : killed by B-rays . b- NaI : (-) the release of hormones
c- propylthiouracil : low binding to blasma protein. d- carbimazole : (-) peroxidase
.All the following cause in the receptors of insulin , except : exercise -27
. Not decrease the release of insulin : alpha 2 antagonist -28
Mismatch in the ttt of DM : Long acting insulin : Lente -29
. Bigumids CI in the hypoxia coz : Its increase the lactic acid -30
. octereoids : ttt bleeding oseophegeal varices -31
Not true about clomiphine : (-) aromatease enzyme -32
. Mismatch in the ttt of hyperthirodism: propylthiouracil : (+++) oxidation of I2 -33
Causes hypoglycemia : glipenzide -34
Mismatch : Lispro ( long acting ) -35
Not true about cabrogline : It’s a D2 antagonist -36
Mismatch :urofolltropin( FSH & LH ) -37
Not true for prolactine : Cabroglin :  the secretion -38

:CVS
:Mismatch for ADR-1
. a- statin : myopathy . b- cholysteramine : (-) Vit K absorbtion
. c- fibrate : conctibation . d- nitrate : flushing
. For HPN emergency , we use : Nitrates -2
. Not ADR of captopril : hypokalemia -3
. Not an ADR of Ca channels blocker : hypoglycemia -4
coz Its ( -) the release of insulin *
. one of Nitrates ADR : headache -5
Class II antiarrhytmic drugs : propnalol -6
: The mechanism of action of digitalis -7
. a- (-) Ca channales . b- ( -) Na-Ka ATPase

: Propnalol ttt angina coz its -8

a- Increase the HR. b- increase contraction . c- O2 demand
 the digitalis toxicity : with hypokalemia -9
: ttt of acute pulmonary edema -10
. a- fursamide . b- thiazide . c- captopril
:both pre & after load -11
a- hydralazine . b- captobril c- dirutics
direact inhibition of the conversion of plasmonogin into plasmin : Altipase -12
ttt of acute glaucoma : Acetazolamide -13
.C.I in gout : a- Niacine b- statine c- fibrate -14
.Mismatch : Niacine : has antioxidant function -15
:Pateint arrived to the ICU with ventricular arrhythmia & MI , we should give him -16
. a- Digoxine . b- lidocine . c- verapmil . d- adenocine

:Mismatch (ADR) -17

. a- captopril : cough . b- clonidin: rebound HPN . c- hydrolysin : bradycardia
.True about enalopril : (-) the conversion of AT I into AT II -18
: The ttt of the digoxine overdose -19
. a- verapmile . b- phenytoin . c- digibind

: Mechanism of GTN action -20

. PDE (-) . 2- B-blocker . 3- alpha agonist . 4- cGMP – No -1
: Fursmide act on -21
. a- collecting duct . b- ascending loop of Henle . c- PCT . d- descending loop
: mechanisms of dirutics functions -22
a- loop of dirtucs :ttt hypercalcemia . b- spirenolactone : for 1ry&2ry aldestronesm
c- Manitole : ttt edema
: Causes atrial & veneous VD -23
.a- manixidine . b- diazoxide . c- hyralazine . d- nitrobrosside
: Mismatch -24
. a- enoxprin : LMW heparin. b-protamin : anti heparin
c- Ticlopidine : Anti ptt . d- Streptokinase : antifibronolytic

not true about cemitidine :decrease the t 1\2 of heparine -25

.LL ca channel blocker : amlodapine -26
Not used to ttt hyperlipedemia : Verapmil -27
.ttt severe HPN : Na nitroprossid -28
. acute angina ( ttt ) : nitroglycrine -29
Chinichism : qunidine -30
. not true about digoxine : t1\2 is 7 days -31
Specific fibrenolytic drug : t-PA -32

: Matching
. a- Osmotic dirutics : manitole . b- thick loop : fursmide
c- (-) aldesterone : spironolactone . d- (-) carbonic anhydrase : acetazolamine
. a- lidocine : ventricular arrhythmia . b-adonsine : supraventicular tachycardia

:Antibiotics ( antibacterial- antifungal- antiparasitic- )

: Mismatch in the mechanisms of actions -1
. Sulphonamides : increase the cell membrane permibility
.Not true about AmphotrcinB : t1\2 is less than 6 hr -2
Not true about Ketoconazole : effective against aspirogillosis -3
. Isonazide ( not true ) : Broad spectrum antibiotic -4
. Rifampin ( not true ) : Its an enzymatic inhibitor -5
Used to ttt bacteria that developed Gentamycin resistance : amikacin -6

Mismatch : cotrimoxazole is acombination b\w culvinic acid&trimethoprim -7

. Not true for the ttt of active TB :streptomycin always given with pyridoxine -8
Fluroquinole : not given for children -9
. Doxcycline : decrease the absorbtion with milk&antacid -10
.Not a B-lactam antibiotics : Azithromycine -11
Mismatch :Diloxinide furoate : used in pregnancy -12
. Not true for clofazamine : Its releated to sulphonamide -13
ttt of liver ameaba with cardiac arrhythemia : Metronidaole & diloxanide furate -14
Clorquine in the ttt of malaria : eradicate th erythrocytic shizoints -15
.Safe in the ttt of pregnancy : ampicilline -16
.Not true about clormphinicol : Not cross BBB -17
. ttt of B-Fragilis : cefoxitine -18
. Causes psudomembrance colitis : Clindamycine -19
.Not true about the mechanism of action of sulphonamide : (-) DHFR -20
Not a use of erythromycine : Rictessia -21

: Not true about anti-malaria -22

.Primiquine is used for patient with G6PD
. Not true for flucanazole : ttt aspirogillosis -23
.Not ttt the dermatophytes : nystatine -24
Causes ototoxocity : Topramycine -25
. Co- trimoxazole ( Not true ) : ttt the ulcerative colitis -26
. Impenem : used with cilastatin -27
. The drug which causes ( - ) of BM : chlormphinicole -28
. cross BBB even in the normal person : chlormphinicole -29
PAS : ttt of TB -30
. Cefotetan : ttt B- fragillus -31
. Not true about dapsone : Its bactreocidal -32
ttt of streptpnumonia with B-lactmase resistance : leavofloxacin -33
Not used to ttt anchylostoma : niclosamide -34
.Mismatch :Ivermectine : (-) DNA -35
Not true about ttt of lishmania : Pragunil is the drug of choice -36

Matching
. ADR:a- Meflquine : convulsion . b- clorquine : corneal opacity -)1
. c- quinine : crichnosim d- gentamycine : ototoxicity
. a- Ampicillin : infectious mononucleosis . b- erythromycine : jaundice-)2
. c- clindmycine : colitis . d- pyrazinamide : gout

:Chemotherapy ( Imm stimulant&suppressor )

.Affected by allopuranole : 6MP -1
.Not true for vinpristine : more (-) of BM than vinblastine -2
Not true for IFN : ( I don't know what is the write answer !!!) -3
.a- given P.O . b- (-) BM

: Matching
a-leucvrin : methotroxate antidote. B- L-asprginase : hydrolysis of aspirgines -)1
. c- Trastumab:monoclonal Abs ttt the breast C.A.d- Mechlorthamine:alkylating agent

: ADR -)2
. a- doxorubicin : cardiotoxocity . b- bleomycin : pulmonary fibrosis
. c- vincristine : neurotoxocity . d- cisplatine : nephrotoxcity

a- Thalamide : (-) TNF . b- Tacroimus : (-) IL2 -)3

c- mofetil : (-) inosine monophospate dehydrognase . d- leflonamide: (-) DHOR
.a- Stanazolol : P.O anapolic steroids b- pridnsolone : P.O corticosteroids -)4

:Essay( From all the topics )

C . I of NSAID . 2- 4 ADR of tetracycline . 3- 4 ADR of metronidazole 4 -1
mechanism of of cholichistine(Antigout). 5-2different b\w tolbumid&glibenzide 4 -4
. diffr b\w erythromycine & azithromycine . 7- 4 drugs used to ttt psudomonus 4 -6
uses of digoxin . 9- 4 uses of prazyquintal . 10- 4- mechanisms of prokinitics 2 -8
CYCLOPHOSMIDE: a-mechanism . b- the main toxicity . c- the cause of (b) d-antidote -11
Describe the meaning & implication of the Log concept of the ttt of cancer -12
‫ أتمنى يكون حظكم أحسن وتعرفوا إجابته قبل االختبار‬،، ‫ وبصراحة نص البنات وقفوا عليه‬،، ‫هذا السؤال عجيب غريب‬
!!! ‫مو بعده‬
. mechanisms of antiviral drugs , with example for each 4 -13
.diffr b\w heparine & enxoparin . 15- 2 CI of ACE I . 16- 4 ADR of amidrone 2 -14
mechanisms of contraceptive ( Progesteron& estrogene ) 4 -17
mechanisms of corticosteroids as antinflematory drugs -4 -18
.uses of pencilline G 4 -19