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Preeclampsia; Scientists at Municipal Institute of Medical Research report

research in preeclampsia
Anonymous. Hematology Week. Atlanta: Jun 7, 2010. pg. 520
Abstract (Summary)

2010 JUN 7 - (<http://www.newsrx.com> NewsRx.com) -- A new study, 'Use of acetaminophen during


pregnancy and risk of preeclampsia, hypertensive and vascular disorders: a birth cohort study,' is now available
(see also <http://www.newsrx.com/library/topics/Preeclampsia.html> Preeclampsia). "To examine whether
pregnant women who used acetaminophen, a prostaglandinG2 synthase inhibitor, had an increased risk of
preeclampsia, gestational hypertension, thromboembolic complications, or abruptio placentae. We selected
63,833 women participating in the Danish National Birth Cohort who gave birth to a live born singleton and had
information on acetaminophen use during pregnancy reported by three interviews," researchers in Barcelona,
Spain report.

xFull Text
(331 words)
(c)Copyright 2010, Hematology Week via NewsRx.com

2010 JUN 7 - (<http://www.newsrx.com> NewsRx.com) -- A new study, 'Use of acetaminophen during


pregnancy and risk of preeclampsia, hypertensive and vascular disorders: a birth cohort study,' is now available
(see also <http://www.newsrx.com/library/topics/Preeclampsia.html> Preeclampsia). "To examine whether
pregnant women who used acetaminophen, a prostaglandinG2 synthase inhibitor, had an increased risk of
preeclampsia, gestational hypertension, thromboembolic complications, or abruptio placentae. We selected
63,833 women participating in the Danish National Birth Cohort who gave birth to a live born singleton and had
information on acetaminophen use during pregnancy reported by three interviews," researchers in Barcelona,
Spain report.
"Through linkage to the National Hospital Discharge Registry we obtained data from hospital diagnose of the
outcomes we study. Women who used acetaminophen during the third trimester of pregnancy had an
increased risk of preeclampsia (adjusted relative risk RR=1.40, 95% CI: 1.24-1.58). The risk was higher among
women who had early preeclampsia (before the 32nd gestational week) (RR=1.47, 95% CI: 1.12-1.93), severe
preeclampsia (RR=1.51, 95% CI: 1.15-2.00), or chronic hypertension (RR=1.44, 95% CI: 1.13-1.83). Second
and third trimester use was associated with an increased risk of pulmonary embolisms (RR=3.02, 1.28-7.15)
and deep vein thrombosis (RR=2.15, 1.06-4.37), respectively," wrote C. Rebordosa and colleagues, Municipal
Institute of Medical Research.
The researchers concluded: "Acetaminophen use during pregnancy is associated with an increased risk of
diseases in which a reduction of prostacyclin during pregnancy has been postulated to play a role, including
preeclampsia and thromboembolic diseases."
Rebordosa and colleagues published their study in the Journal of Maternal-fetal & Neonatal Medicine (Use of
acetaminophen during pregnancy and risk of preeclampsia, hypertensive and vascular disorders: a birth cohort
study. Journal of Maternal-fetal & Neonatal Medicine, 2010;23(5):371-8).
For additional information, contact C. Rebordosa, Municipal Institute of Medical Research (IMIM-Hospital del
Mar), Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
Keywords: City:Barcelona, Country:Spain, Acetaminophen, Acetanilides, Cardiovascular Diseases, Eclampsia,
Hospital, Hypertension, Preeclampsia, Vascular Diseases.
This article was prepared by Hematology Week editors from staff and other reports. Copyright 2010,
Hematology Week via <http://www.newsrx.com> NewsRx.com.
305 PQ REVERSE_CHRO 1294136681

Indexing (document details)


People: Rebordosa, C
Author(s): Anonymous
Document types: Expanded Reporting
Publication title: Hematology Week. Atlanta: Jun 7, 2010. pg. 520
Source type: Periodical
ISSN: 15436721
ProQuest document 2047872701
ID:
Text Word Count 331
Document URL: http://proquest.umi.com/pqdweb?
did=2047872701&sid=8&Fmt=3&clientId=71572&RQT=309&VName=P

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