Product Information Novel Kinase Inhibitors

for cell signaling & oncology research

Toll Free:
S2151 LDE225 (877)796-6397
-- USA and Canada only --
» Smoothened (Smo)
Fax:
+1-713-796-9816
Technical Data:
Orders
M.Wt: 485.5
+1-713-922-4115
F3CO
Formula: C26H26F3N3O3 enquiry@selleckchem.com
Solubility: Unknown N
Purity: 99% HN N O Tech Support
tech@selleckchem.com
Storage: at -20℃ 2 years O
(chemistry support)
CAS No.: 956697-53-3 Synonyms: NVP-LDE225 techbio@selleckchem.com
(bio support)

Web
Biological Activity
www.selleckchem.com
LDE225(NVP-LDE225) is a novel and specific, orally bioavailable Smo inhibitor with an IC50 of
11 nM. It has been shown to potentially inhibit Hh-and Smo-dependent proliferation in vivo. It
also induced the regression of preformed basaloid lesions with an IC50 of <150 nmol/l and almost
complete regression at 1.5 μmol/l. Topical application of a 1% LDE225(NVP-LDE225) solution to
depilated skin of C57/BL6 mice completely inhibited hair growth during anagen phase as well as
the expression of the Hh-pathway target genes (Gli1, Gli2, Sox9, and N-Myc) and partial inhibition
Selleck Overnight Delivery Service
was obtained when applying a 0.3% solution. [1][2]

References Return Policy

[1] Stuetz A. et al. Melanoma Research. 2010 6; 20: 40 Please inspect packages immediately upon

receipt and notify customer service within

[2] Kalthoff F. et al. Melanoma Research. 2010 6; 20: 70-71 3 days of delivery of any damage or

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