PATHOPHYSIOLOGY

Infarct Left Middle Cerebral Artery

Source: Pathophysiology of Altered Health States(Carol-Mattson-Porth)
Theoretical-Based

MODIFIABLE: NON-MODIFIABLE:
Smoking Age
Obesity Gender
Diet Heredity
Lifestyle race
Hypercholesterolemia
Hypertension
CVD
Environment

Build up of foreign
bodies(nicotine, fats)

Atherosclerosis(plaque
formation)

Embolus

Sudden increase in blood

pressure(compensatory
mechanism)

Embolus will eventually lodge

in a blood vessel

Thrombus at carotid artery

Thrombus at carotid artery

 Decreased blood supply in
MCA (decreased oxygen)

Damaged cells will leak Ca Tissue death(infarction)

and glutamate

Decreased blood supply in the

following areas:

HORIZONTAL SEGMENT (M1) SYLVIAN SEGMENT (M2)

TEMPORAL LOBE:
PARIETAL LOBE:
Prospagnosia
Right: Ocular Apraxia
Long-term memory
Simultagnosia
Auditory and visual
Optic ataxia
(Hemianopsia)
Left: Gerstmann Syndrome
sensation and perception
R-L confusion
Difficulty in language
Acalculia
comprehension

LATERAL LENTICULOSTRIATE
CORTICAL SEGMENT (M3)

FRONTAL LOBE:
Decreased level of
CEREBELLUM:
consciousness
Balance
Altered personality
Motor
Paralysis
Muscle Tone
Broca’s Aphasia
Mood Changes
Problem Solving
Wernicke’s Aphasia