Medicines List

Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list.
His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F
Ibrahim Abdullah - http://sir-ib.blogspot.com
Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions
Patients less than 18 years, chronic intestinal Thiazide and other diuretic, corticosteriod,
Only for treatment of: i) Non insulin dependent diabetes
disorders associated with distinct disturbances of thyroid product, estrogens, oral contraceptives,
mellitus (NIDDM) when diet therapy is insufficient ii) Asymptomatic liver enzyme elevations especially at
Initially 50 mg daily, increase to 3 times daily up to 100 Flatulence and bowel sounds, diarrhoea and digestion and absorption, conditions which may phenytoin, nicotinic acid, sympatomimetic,
Acarbose 50 mg Tablet Glucobay Non insulin dependent diabetes mellitus (NIDDM) in higher dosages. Monitor liver enzyme during 6 - 12
mg 3 times daily. Max 200 mg 3 times daily abdominal pain deteriorate as a result of increased intestinal gas calcium channel blocker, isoniazid,
combination with existing conventional oral therapy months of treatment
formation, pregnancy, lactation, severe renal cholestyramine, intestinal absorbents, digestive
where glycaemic control is inadequate
impairment enzymes
Not generally recommended for prolonged use but if
given monitor blood count and plasma electrolyte Nausea, vomiting, diarrhoea, taste disturbances,
concentration, pulmonary obstruction (risk of loss of appetite, paraesthesia, flushing,
Reduction of intraocular pressure in open-angle Hypokalaemia, hyponatraemia, hyperchloraemic
acidosis), elderly, pregnancy and lactation, Stevens- headache, dizziness, fatigue, irritability, Aspirin, cyclosporin, digitalis , digoxin, lithium,
Acetazolamide 250 mg Tablet Diamox glaucoma, secondary glaucoma and peri-operatively in 250 - 500 mg daily acidosis, severe hepatic impairment, renal
Johnson syndrome, toxic epidermal necrosis, high- depression, thirst, polyuria, reduced libido, phenytoin, quinidine, topiramate
angle-closure glaucoma impairment, sulphonamide hypersensitivity
dose aspirin, high dose may decrease diuresis and metabolic acidosis and electrolyte disturbances
may increase drowsiness, pulmonary obstruction or on long-term therapy
emphysema
Not generally recommended for prolonged use but if

given monitor blood count and plasma electrolyte Nausea, vomiting, diarrhoea, taste disturbances,
concentration, pulmonary obstruction (risk of loss of appetite, paraesthesia, flushing,
Reduction of intra-ocular pressure in open-angle Hypokalaemia, hyponatraemia, hyperchloraemic
acidosis), elderly, pregnancy and lactation, Stevens- headache, dizziness, fatigue, irritability, Aspirin, cyclosporin, digitalis, digoxin, lithium,
Acetazolamide 500 mg Injection Diamox glaucoma, secondary glaucoma and peri-operatively in 250 - 500 mg given by IM or IV acidosis, severe hepatic impairment, renal
Johnson syndrome, toxic epidermal necrosis, high- depression, thirst, polyuria, reduced libido, phenytoin, quinidine, topiramate
angle-closure glaucoma impairment, sulphonamide hypersensitivity
dose aspirin, high dose may decrease diuresis and metabolic acidosis and electrolyte disturbances
may increase drowsiness, pulmonary obstruction or on long-term therapy
emphysema
Carbamazepine : increased risk of
Diluted with dextrose 5% and infused IV. Initial, 150
Asthma, history of bronchospasm and risk of Bronchoconstriction, nausea, vomiting, subtherapeutic carbamazepine levels.
mg/kg IV in 200 ml over 60 minutes, then 50 mg/kg IV in
Acetylcysteine 200 mg/ml Injection Parvolex Antidote for paracetamol poisoning anaphylactoid reactions and history of peptic anaphylactic reactions, rash, hypotension, Hypersensitivity to acetylcysteine products Nitroglycerin : enhanced hypotension and
500 ml over 4 hours, followed by 100 mg/kg IV in 1000
ulceration pruritus, rash, urticaria nitroglycerin-induced headache. Penicillin G,
ml over 16 hours. Total dose: 300mg/kg in 20 hour
tetracycline : loss of antibiotic efficacy
Alcohol, dipyridamole, metoclopramide,
Prevention of myocardial infarct, stroke, vascular Dyspepsia, gastric mucosal lesions, haemorrhagic Nausea, vomiting, dyspepsia, GI ulceration, metoprolol, carbonic anhydrase inhibitors,
Acetylsalicylic Acid 100 mg, Glycine
occlusion and deep vein thrombosis. Transient 1 tablet daily disorders, gout, intolerant to aspirin, renal or hepatic haematemesis, malaena. Occasionally Bleeding disorders. Hypersensitivity to salicylate corticosteroids, coumarin anticoagulants,
45 mg Tablet
ischaemic attacks impairment, asthma and G6PD deficiency hepatotoxicity sulphonylureas, methotrexate, phenytoin,
valproic acid, probenecid, sulphinpyrazone
Acetazolamide, Dipyridamol : salicylate toxicity
Gastric and duodenal ulcers, haemorrhagic (vomiting, tachycardia, hyperpnea, mental
Renal disorders, G6PD deficiency, pregnancy,
diathesis, hypersensitivity to aspirin or other confusion) or acetazolamide toxicity (fatigue,
patients with flu, chicken pox or haemorrhagic fever. Gastric haemorrhage, hypersensitivity,
NSAIDs, children under 12 years lethargy, somnolence, confusion, hyperchloremic
History of peptic ulcer or those prone to dyspepsia thrombocytopenia,GI disturbances; prolonged
Acetylsalicylic Acid 300 mg Soluble 300 - 900 mg every 4 - 6 hours as required. Max 4 g old.Hypersensitivity (attacks of asthma, metabolic acidosis). Alendronate : GI distress.
Aspirin Soluble Mild to moderate pain and those with gastric mucosal lesion; asthma or bleeding time, rhinitis, urticaria and epigastric
Tablet daily. Use in children not recommended angioedema, urticaria or rhinitis); pregnancy Antacids, calcium. Alcohol, corticosteroids,
allergic disorders; dehydrated patients; uncontrolled discomfort; angioedema, salicylism, tinnitus;
(third trimester); patients with haemophilia or phenylbutazone and oxyphenbutazone may
hypertension; impaired renal or hepatic function; bronchospasm
haemorrhagic disorders; gout; severe renal or increase risk of GI ulceration. Aspirin increases
elderly
hepatic impairment; lactation phenytoin levels. May antagonize actions of
uricosurics and spironolactone
ADULT: initially 25-30 mg daily for 2-4 weeks, then Oral contraceptives, progestogen may result in
Generalised pustular and or erythrodermic psoriasis,
adjusted according to response, usually within range 25- Symptoms of hypervitaminosis A, localized but Pregnancy and lactation, liver and kidney loss of contraceptive effectiveness. Ethanol may
pityriasis rubra pilaris, Darier's Disease, Icthyosiform Long-term treatment, diabetes, obesity, alcoholism,
Acitretin 10 mg Capsule Neotigason 50 mg daily for further 6-8 weeks (max: 75 mg daily). reversible hair loss, thinning and scaling of the insufficiency, hypervitaminosis A, excessively result in a prolonged risk of teratogenicity.
Erythrodermas - Bullous and non-bullous forms, disturbances of lipid metabolism
CHILD: 500 mcg/kg daily occasionally up to 1 mg/kg skin, paronychia, muscle and joint pain elevated blood lipid values Possible hypervitaminosis with vitamin A.
extensive naevus verrucosus, extensive psoriasis
daily to a max. 35 mg daily for limited periods Reduces protein binding of phenytoin
ADULT: initially 25-30 mg daily for 2-4 weeks, then Oral contraceptives, progestogen may result in
Generalised pustular and or erythrodermic psoriasis,
adjusted according to response, usually within range 25- Symptoms of hypervitaminosis A, localized but Pregnancy and lactation, liver and kidney loss of contraceptive effectiveness. Ethanol may
pityriasis rubra pilaris, Darier's Disease, Icthyosiform Long-term treatment, diabetes, obesity, alcoholism,
Acitretin 25 mg Capsule Neotigason 50 mg daily for further 6-8 weeks (max: 75 mg daily). reversible hair loss, thinning and scaling of the insufficiency, hypervitaminosis A, excessively result in a prolonged risk of teratogenicity.
Erythrodermas - Bullous and non-bullous forms, disturbances of lipid metabolism
CHILD: 500 mcg/kg daily occasionally up to 1 mg/kg skin, paronychia, muscle and joint pain elevated blood lipid values Possible hypervitaminosis with vitamin A.
extensive naevus verrucosus, extensive psoriasis
daily to a max. 35 mg daily for limited periods Reduces protein binding of phenytoin
Infected skin, lesions, cuts, abrasions, wounds and
Acriflavine 0.1% Lotion - Apply undiluted three times daily to the affected part . Prolonged application, may stain skin, hair & fabric. Hypersensitivity to acriflavine compound Hypersensitivity to acriflavine compound. Not known
burns.
i) ADULT: 500 mcg IV daily for max of 5 days. CHILD: Myelosuppression, nausea, vomiting, mucositis,
1.5 mg/m2 once every 3 weeks (if weight less than 10 Avoid extravasation, severe soft tissue damage. alopecia, rash, radiation recall reactions, Live vaccines may result in an increase risk of
Actinomycin D (Dactinomycin) 500 i) For solid tumours ii) Gestational trophoblastic Pregnancy, lactation, chickenpox or herpes
Cosmegen kg, 50 mcg/kg) ii) 500 mcg IV on Days 2, 4, 6, 8, 10, Concomitant radiation therapy may exaggerate hepatitis. Malaise, fatigue, fever, myalgia, infection, radiation therapy, possibly reduced
mcg/ml Injection disease zoster infection
repeat every 7 - 10 days or 500 mcg IV bolus on Days dactinomycin toxicity gastrointestinal, haematologic and dermatologic absorption of phenytoin
1 and 2, repeat every 15 days effects
Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list. His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F
i) Mucocutaneous Herpes Simplex infection in
immunocompromised and AIDS patients ii) Primary and
i) ADULT: initially 400 mg 5 times daily for 7 - 14 days.
recurrent Varicella Zoster infection in
CHILD less than 2 years: 200 mg 4 times daily, CHILD
immunocompromised and AIDS patients iii) Severe
more than 2 years: 400 mg 4 times daily ii), iii) and iv)
Kaposi Varicella Eruption (Eczema herpeticum) iv)
ADULT: 200 - 400 mg 4 times daily. CHILD: less than 2
Severe primary HSV infections (eg. Neonatal herpes, Patients with pre-existing neurologic, renal, or
years, half adult dose; more than 2 years, adult dose v) Increased mean half-life & plasma concentration
Acyclovir 200 mg Tablet Zovirax encephalitis, eczema herpeticum, genital herpes, hepatic impairment, dehydrated patient, elderly and Skin rashes; GI effects; fatigue Patients known to be hypersensitivity to acyclovir
ADULT: 800 mg 5 times daily for 7 days vi) ADULT: 20 with probenecid
gingival stomatitis, vaginal delivery with maternal vulva lactation
mg/kg (maximum: 800 mg) four times daily for 5 days,
herpes) v) Severe and complicated varicella infection
CHILD 6 years: 800 mg four times daily. CHILD less
(eg. Encephalitis, purpura fulminans) vi) Severe zoster
than 2 years; 400mg 4 times daily, more than 2 years;
infection in paediatrics (eg. Encephalitis, purpura
800mg 4 times daily
fulminans, immunocompromised patients and facial,
sacral and motor zoster)
ADULT: 200 - 400 mg 4 times daily. CHILD : less than 2
years, half adult dose; more than 2 years, adult dose. v) Increased mean half-life & plasma concentration
Acyclovir 200 mg/5 ml Suspension Zovirax encephalitis, eczema herpeticum, genital herpes, hepatic impairment, dehydrated patient, elderly and Skin rashes, GI effects, fatigue Patients known to be hypersensitivity to acyclovir
CHILD 6 years: 800 mg four times daily. CHILD: less
infection in paediatrics (eg.Encephalitis, purpura
800 mg 4 times daily
ADULT: 5 mg/kg by IV infusion 8 hourly for 5 days,
doubled to 10mg/kg every 8 hourly in varicella-zoster in
the immunocompromised and in simplex encephalitis
(usually given for at least 10 days in encephalitis;
possibly for 14 - 21 days). NEONATE & INFANT up to 3
In patients receiving Zovirax IV at higher doses,
Treatment and prophylaxis of herpes simplex in months with disseminated herpes simplex: 20mg/kg
specific care regarding renal function should be Skin rashes; GI effects, neurological reactions Increased mean half-life & plasma concentration
Acyclovir 250 mg Injection Zovirax immunocompromised, severe initial genital herpes and every 8 hourly for 14 days (21 days in CNS Patients known to be hypersensitivity to acyclovir
taken, particularly when patients are dehydrated or (IV infusion) with probenecid
Varicella -Zoster involvement), varicella-zoster 10-20mg/kg every 8
have any renal impairment
hourly usually for 7 days. CHILD, 3 months - 12 years:
Herpes simplex or Varicella Zoster: 250 mg/m2 8 hourly
for 5 days, doubled to 500 mg/m2 8 hourly for varicella-
zoster in the immunocompromised and in simplex
encephalitis (usually given for 10 days in encephalitis)
Apply 1 cm 5 times daily. Continue for at least 3 days Local irritation and inflammation reported , vision
Acyclovir 3% Eye Ointment Zovirax Only for the treatment of herpes simplex keratitis Not known Hypersensitivity to acyclovir Not known
after healing abnormalities
Herpes simplex infections of the skin, including initial
Application to mucous membranes, pregnancy, Transient burning or stinging or erythema, mild
Acyclovir 5% Cream Zovirax and recurrent labial and genital herpes simplex Apply every 4 hours for 5 - 10 days Hypersensitivity to acyclovir or valacyclovir Not known
lactation. Should not be used in the eyes drying or flaking of the skin
infections
ADULT: 200 - 400 mg 4 times daily. CHILD: less than 2
years, half adult dose; more than 2 years, adult dose v) Increased mean half-life & plasma concentration
Acyclovir 800 mg Tablet Zovirax encephalitis, eczema herpeticum, genital herpes, hepatic impairment, dehydrated patient, elderly and Skin rashes; GI effects; fatigue Patients known to be hypersensitivity to acyclovir
CHILD 6 years: 800 mg four times daily. CHILD less
infection in paediatrics (eg. Encephalitis, purpura
800mg 4 times daily
Hypertension, injection site reaction, rash,
autoantibody, erythema multiforme, primary
Reactivation of tuberculosis (patients should be
cutaneous vasculitis, Stevens-Johnson
evaluated for tuberculosis before treatment), serious
Syndrome, aplastic anemia, leukopenia,
Third line treatment of: i) Severe rheumatoid arthritis ii) infection, lupus-like syndrome & confirmed
thrombocytopenia, anaphylaxis, malignant Hypersensitivity to adalimumab or any Anakinra, abatacept, live vaccine, leflunomide,
Adalimumab 40 mg Injection Humira® Psoriatic arthritis iii) Ankylosing spondylitis after failure Subcutaneous 40 mg every other week significant hematologic abnormalities, CHF &
lymphoma, multiple sclerosis, paraesthesia, component of the formulation, severe infection topical tacrolimus, trastuzumab
of conventional DMARDs or other biologics development of symptoms of blood dyscrasias,
subdural hematoma, interstitial lung disease,
women of childbearing potential, pregnancy &
angioedema, fatal infectious disease including
lactation
tuberculosis, invasive fungal infections and other
opportunistic infections
Avoid contact with eyes, lips angles of the nose and
Acne vulgaris where comedones, papules and pustules
Apply once daily to the affected areas after washing at mucosa membranes. Do not apply to cuts, abrasion, Erythema, scaling, dryness, pruritus, burning Hypersensitivity to adapalene or any of its
Adapalene 0.1% Cream Differin predominate in those sensitive to benzoyl peroxide or Methotrexate
bedtime eczematous skin or sunburned skin. Minimize sensation components
topical tretinoin [third line treatment]
exposure to slight, including sunlamps
Avoid contact with eyes, lips angles of the nose and
Acne vulgaris where comedones, papules and pustules
Apply once daily to the affected areas after washing at mucosa membranes. Do not apply to cuts, abrasion, Erythema, scaling, dryness, pruritus, burning Hypersensitivity to adapalene or any of its
Adapalene 0.1% Gel Differin predominate in those sensitive to benzoyl peroxide or Methotrexate
bedtime eczematous skin or sunburned skin. Minimize sensation components
topical tretinoin [third line treatment]
exposure to slight including sunlamps
Monitor renal function. Patients at risk of or with
i) Treatment of chronic HBeAg positive and HBeAg underlying renal dysfunction & those receiving
negative hepatitis B infection in adults with medicine that may affect renal function. Advanced
Aminoglycosides, ibuprofen,
compensated liver function (lamivudine should be tried liver disease or cirrhosis. Patients with Renal impairment and failure, increase serum
immunosuppressant, nephrotoxic agents,
Adefovir Dipivoxil 10 mg Tablet Hepsera first) ii) Lamivudine-resistant chronic hepatitis B virus Adult over 18 years: 10mg once daily hepatomegaly, hepatitis or other known risk factors creatinine, abdominal pain, flatulence, diarrhoea, Hypersensitivity to adefovir
NSAIDs, vancomycin, ganciclovir, valganciclovir,
infection with either compensated or decompensated for liver disease. Co-infection with HIV. Congenital dyspepsia, hepatitis
ribavirin
hepatitis function (only by hepatologist and carnitine deficiency. Pregnancy & lactation. Women
gastroenterologist for approved indications) of childbearing potential must use effective
contraception
ADULT: Initially: 3 mg given as a rapid IV bolus (over 2
Facial flush, dyspnoea, a feeling of thorasic
seconds). Second dose: If the first dose does not result Avoid concomitant use of dipyridamole and
constriction, nausea, lightheadedness, feeling of Bradycardia, bronchoconstrictive or
in elimination of the supraventricular tachycardia with in methylxanthines (eg: caffeine, theophylline). Cardiac
discomfort, sweating, palpitations, bronchospastic lung disease (eg. asthma). Actions may be potentiated by dipyridamole and
Rapid conversion of paroxysmal supraventricular 1 or 2 minutes, 6 mg should be given also as a rapid IV arrest, heart block, heart transplant patients,
Adenosine 3 mg/ml Injection Adenocor hyperventilation, head pressure, apprehension, Hypersensitivity to adenosine, second-degree or carbamazepine. Theophylline & caffeine inhibit
tachycardia to sinus rhythm bolus. Third dose: If the second dose does not result in hypertension, hypotension, myocardial infarction.
blurred vision, burning sensation, bradycardia, third-degree AV block (unless pacemaker fitted), its action
elimination of the supraventicular tachycardia with in 1- Proarrhythmic events; new rhythms, particularly at
chest pains, headache, dizziness, heaviness in sinus node disease (eg. sick sinus syndrome)
2 minutes, 12 mg should be given also as a rapid IV time of conversion and unstable angina
arms, arm, back and neck pains; metallic taste
bolus
Cardiac dilatation, coronary insufficiency. Within
2 weeks of MAOI use.Organic brain damage,
Elderly patients, patients with; CV disease, narrow-angle glaucoma. Shock. Concurrent use
Beta-blocking,alpha-adrenergic blockers
pulmonary oedema, hypertension, hyperthyroidism, with local anesthetics for injection of certain
agents,antihistamines,tricyclic antidepressants
Adrenaline Acid (Epinephrine) diabetes, psychoneurotic illness, asthma, Hypertension, arrhythmias, nausea, vomiting, areas (eg; fingers, toes, ears); increased risk of
- Cardiopulmonary resuscitation 0.5-1 mg given by SC or IM carvedilol, chlorpromazine, halothane,
Tartrate 1 mg/ml Injection prefibrillatory rhythm, or anesthetic cardiac acidents. headache, shortness of breath, sneezing vasoconstriction and sloughing of tissue.
moclobemide, rocuronium, selegiline,
Bronchial asthma/emphysema,cerebrovascular oncurrent use with cyclopropane or halogenated
timolol,methyldopa, diuretics, oxytoxic drugs
hemorrhage, pregnancy, lactation, children hydrocarbon anaesthetics; may produce fatal
ventricular arrhythmias. Labor; may delay the
second stage
Gastrointestinal discomfort, dizziness, headache,
Discontinue therapy if liver function test elevations Patients with hypersensitivity to albendazole or
i) ADULT and CHILD over 2 years : 400 mg as a single erythema multiforme, Stevens-Johnson Concurrent use with dexamethasone may result
i) Single or mixed infestations of intestinal parasites ii) are significant, retinal lesions, cerebral hypertensive to the benzimidazole drug class, pregnancy
Albendazole 200 mg Tablet Zentel dose ii) 400 mg as a single dose for 3 consecutive syndrome, agranulocytosis, aplastic anemia, in an increased risk of albendazole adverse
Strongyloides infection episodes, pregnancy, hepatic disease, retinal (avoid pregnancy for at least one month following
days. CHILD 12 - 24 months : half adult dose leukopenia, pancytopenia, thrombocytopenia, effects.
lesions therapy)
hepatotoxicity
Gastrointestinal discomfort, dizziness, headache,
Discontinue therapy if liver function test elevations Patients with hypersensitivity to albendazole or
i) ADULT and CHILD over 2 years : 400 mg as a single erythema multiforme, Stevens-Johnson Concurrent use with dexamethasone may result
i) Single or mixed infestations of intestinal parasites ii) are significant, retinal lesions, cerebral hypertensive to the benzimidazole drug class. Pregnancy
Albendazole 200 mg/5 ml Suspension Zentel dose ii) 400 mg as a single dose for 3 consecutive syndrome, agranulocytosis, aplastic anemia, in an increased risk of albendazole adverse
Strongyloides infection episodes, pregnancy, hepatic disease, retinal (avoid pregnancy for at least one month following
days. CHILD 12 - 24 months : half adult dose leukopenia, pancytopenia, thrombocytopenia, effects
lesions therapy)
hepatotoxicity
Mental impairment, gastrointestinal disturbances,
Chlorpropamide, metronidazole, cefoperazone,
Alcohol 70% Solution - Use as antiseptic and disinfectant Apply to the skin undiluted or when needed Pregnancy, nursing mothers, elderly severe effects include respiratory depression, Not known
cefoperazone/sulbactam and cefotaxime
coma and death
70 mg once weekly. Swallow the tablet whole with a full
Concurrent use with aspirin and mesalamine
Osteoporosis in post menopausal women with a history glass of plain water only on an empty stomach at least Creatinine clearance less than 35 ml/min, vitamin D Oesophageal reactions, abdominal Hypersensitivity to alendronate products,
may result in gastrointestinal distress.
Alendronate Sodium 70 mg Tablet Fosamax of vertebral fracture and whom oestrogen replacement 30 minutes before breakfast (and any other oral and mineral deficiencies to be corrected before pain,musculoskeletal hypocalcaemia, esophageal abnormalities,
Concurrent use with calcium and antacids may
therapy is contraindicated medication); stand or sit upright for at least 30 minutes initiating therapy pain,headache,diarrhoea,constipation inability to stand or sit upright for 30 minutes
result in reduced alendronate absorption
and do not lie down until after eating breakfast
Discontinue in case of dysphagia, odynophagia, Urticaria, myalgia, malaise; nausea, vomiting,

Esophageal abnormalities which inhibit
1 tablet once weekly [contains cholecalciferol 2800 retrosternal pain or new or worsening heartburn. esophageal stricture/perforation, oropharyngeal
esophageal emptying (ie, achalasia, stricture),
units in a weekly dose, equivalent to 400 units daily]. Active upper gastrointestinal problems (dysphagia, ulceration; esophagitis, esophageal erosions,
increased risk for adverse esophageal effects, Calcium supplements, antacids. Hormone
Osteoporosis in post menopausal women with a history Swallow the tablet whole with a full glass of plain water esophageal diseases, gastritis, duodenitis or ulcers). esophageal ulcers; localized osteonecrosis of
Alendronate Sodium 70mg and hypocalcemia; decreases in serum calcium and replacement therapy. Olestra, mineral oils,
Fosamax Plus of vertebral fracture and whom oestrogen replacement only on an empty stomach at least 30 minutes before CrCl less 35 ml/min. Correct hypocalcemia and other the jaw; bone, joint and or muscle pain; rash,
Cholecalciferol 2800 IU Tablet phosphate have occurred during therapy, orlistat, cholestyramine, colestipol.
therapy is contraindicated breakfast (and any other oral medication); stand or sit disorders affecting mineral metabolism (eg vit D pruritus, angioedema, fever, hypocalcemia,
resolve hypocalcemia prior to beginning therapy, Anticonvulsants, cimetidine, thiazides
upright for at least 30 min and do not lie down until after deficiency) before starting therapy. Monitor serum gastric or duodenal ulcers, Stevens-Johnson
inability to sit or stand in an upright position for at
eating breakfast Calcium and urine. Children, pregnancy and syndrome, toxic epidermal necrolysis, ocular
least 30 minutes
lactation inflammations (uveitis, iritis, scleritis)
Treatment of: i) Renal osteodystrophy in patients on
Initial dose ADULT and CHILD above 20kg body weight
haemodialysis ii) Hypoparathyroidism and Take care to ensure correct dose to infants, monitor Hypercalcaemia, metastatic calcification, vitamin
: 1 mcg daily; CHILD under 20kg body weight : 0.05 Hypercalcaemia, nausea, vomiting, polydipsia,
Alfacalcidol 0.25 mcg Capsule One-alpha pseudohypoparathyroidism iii) Adjunct to the plasma calcium and creatinine during dosage D toxicity and hypersensitivity to calcitriol Antiepileptics, diuretics, barbiturates
mcg/kg/day. Maintenance dose : 0.25 mcg to 2 mcg polyuria
management of tertiary hyperparathyroidism iv) Rickets titration products.
daily
and osteomalacia v) Osteoporosis
Initial dose ADULT and CHILD above 20kg body weight
: 1 mcg daily; CHILD under 20kg body weight : 0.05 Hypercalcaemia, nausea, vomiting, polydipsia,
Alfacalcidol 1 mcg Capsule one-alpha pseudohypoparathyroidism iii) Adjunct to the plasma calcium and creatinine during dosage D toxicity and hypersensitivity to calcitriol Antiepileptics, diuretics, barbiturates
mcg/kg/day. Maintenance dose : 0.25 mcg to 2 mcg polyuria
management of tertiary hyperparathyroidism iv) Rickets titration products
daily
Hypercalcaemia, nausea, vomiting, polydipsia,
Alfacalcidol 2 mcg/ml Drops One-Alpha pseudohypoparathyroidism iii) Adjunct to the NEONATES : 0.1 mcg/kg/day plasma calcium and creatinine during dosage D toxicity and hypersensitivity to calcitriol Antiepileptics, diuretics, barbiturates
polyuria
management of tertiary hyperparathyroidism iv) Rickets titration products
haemodialysis ii) Hypoparathyroidism and Initial dose : 1 mcg per haemodialysis. Maximum dose Take care to ensure correct dose to infants, monitor Hypercalcaemia, metastatic calcification, vitamin
Hypercalcaemia, nausea, vomiting, polydipsia,
Alfacalcidol 2 mcg/ml Injection One-Alpha pseudohypoparathyroidism iii) Adjunct to the 6 mcg per haemodialysis and not more than 12 mcg plasma calcium and creatinine during dosage D toxicity and hypersensitivity to calcitriol Antiepileptics, diuretics, barbiturates
polyuria
management of tertiary hyperparathyroidism iv) Rickets per week titration. products
Continuous monitoring of vital signs. Initial dose
reduction in the elderly and debilitated. Impaired
hepatic or renal function. Concurrent diazepam may
produce vasodilation and hypotension; resulting in
Diltiazem, fluconazole : prolonged alfentanil
delayed recovery. Head injury, increased intracranial
Hypersensitivity to alfentanil and other opioids. efficacy. Erythromycin : decreased alfentanil
pressure. Pulmonary disease, decreased respiratory
Tacycardia, bradyarrhythmia, cardiac Intolerance to morphinomimetics. In labor or clearance. Itraconazole : increased alfentanil
reserve. Decreased respiratory reserve and
dysrhythmia, hypertension, hypotension, before clamping of the cord during caesarean serum concentrations and potential alfentanil
For use as short acting narcotic analgesic in short Initial dose: 20 - 40 mcg/kg. Supplemental dose: 15 pulmonary disease; prostatic hyperplasia;
Alfentanil HCl 0.5 mg/ml Injection Rapifen respiratory depression, apnoea, muscular section. Respiratory depression and obstructive toxicity (CNS depression, respiratory
procedures and day-care surgical procedures mcg/kg or infusion 0.5 - 1.0 mcg/kg/min hypotension; shock; inflammatory or obstructive
rigidity, dizziness, nausea, CNS disturbances, airways disease; acute alcoholism, convulsive depression). Naltrexone : precipitation of opioid
bowel disorders; myasthenia gravis; hypovolaemia;
vomiting and constipation disorders; head injuries, and conditions in which withdrawal symptoms. Monoamine oxidase
uncontrolled hypothyroidism; alcoholism; chronic
intracranial pressure is raised inhibitors (MAOIs), alcohol and central nervous
opioid therapy and history of opioid abuse. Avoid
system depressants
rapid bolus Injection in compromised intracerebral
compliance. Do not administer during the last 10
minutes of surgery. Pregnancy and lactation. May
affect ability to drive and operate machinery
Gastrointestinal disturbances, vertigo, malaise,
Orthostatic hypotension, hepatic insufficiency,
Elderly, coronary insufficiency, discontinue in the dizziness, headache. Rarely orthostatic
Treatment of functional symptoms related with benign severe renal insufficiency (CrCl less than 30
Alfuzosin HCl 10 mg Tablet Xatral XL 10 mg once a day pre bed event of recurrence or exacerbation of angina, may hypotension, syncope, tachycardia, palpitations, Alpha blockers and other antihypertensives
prostatic hypertrophy (BPH) ml/min), intestinal occlusion. Avoid combination
impair ability to drive or operate machinery chest pain, asthenia, drowsiness, oedema,
with alpha blockers
flushing, dry mouth, rash, pruritis
To be diluted with an equal volume of warm water Epistaxis, not to be used in cranial surgery or trans
Alkaline Nasal Douche To remove nasal plug due to radiation Excessive use can be toxic due to its absorption Not known Not known
before use nasal neuro surgical procedure
Skin rash, maculopapular, pruritic, Stevens-
Johnson Syndrome, peripheral neuritis, alopecia,
Oral anticoagulants, azathioprine, antidiabetics,
GI upset, toxic epidermal necrolysis. Acute
mercaptopurine.Use only quarter of the usual
attack of gouty arthritis in early stages of therapy. Hypersensitivity to allopurinol, pregnancy,
Initial dose : 100-300 mg daily. Maintenance : 300-600 Renal/hepatic dysfunction, asymptomatic dose of 6-mercaptopurine or azathioprine when
Allopurinol 100 mg Tablet Gout or uric acid and calcium oxalate renal stones Skin reactions (discontinue immediately at first lactation, acute gout, asymptomatic
mg daily. Maximum: 900 mg daily hyperuricaemia, hypersensitivity and pregnancy given concurrently. Increases plasma half-life of
sign of rash). Very rarely, granulomatous hyperuricaemia
adenine arabinoside. Effects decreased by
hepatitis. Occasionally; thrombocytopenia,
uricosurics & large doses of salicylates
agranulocytosis, & aplastic anaemia in patients
with impaired renal function
Skin rash, maculopapular, pruritic, Stevens-
Johnson Syndrome, peripheral neuritis, alopecia,
Oral anticoagulants, azathioprine, antidiabetics,
GI upset, toxic epidermal necrolysis. Acute
mercaptopurine.Use only quarter of the usual
attack of gouty arthritis in early stages of therapy. Hypersensitivity to allopurinol, pregnancy,
Initial dose : 100-300 mg daily. Maintenance : 300-600 Renal/hepatic dysfunction, asymptomatic dose of 6-mercaptopurine or azathioprine when
Allopurinol 300 mg Tablet Zyloric Gout or uric acid and calcium oxalate renal stones Skin reactions (discontinue immediately at first lactation, acute gout, asymptomatic
mg daily. Maximum: 900 mg daily hyperuricaemia, Hypersensitivity and pregnancy given concurrently. Increases plasma half-life of
sign of rash). Very rarely, granulomatous hyperuricaemia
adenine arabinoside. Effects decreased by
hepatitis. Occasionally; thrombocytopenia,
uricosurics & large doses of salicylates
agranulocytosis, & aplastic anaemia in patients
with impaired renal function
Headache, fever, weakness, fatigue, nausea,
Concurrent use with drugs which inhibit hepatic
vomiting, dry skin, rash, peripheral oedema,
cytochrome P450 enzyme system, eg
Avoid pregnancy during and for at least 1 month mycosis, conjunctivitis, hypotension,
ketoconazole, cimetidine, ciclosporin, diltiazem,
after stopping treatment. Monitor haematological, hypertension, arrhythmias, heart failure, flushing,
Induction: 45 mg/m2 daily for 30 - 90 days. erythromycin, rifampicin, verapamil may increase
All-Trans Retinoic Acid 10 mg coagulation profile, liver function test, serum lipid dizziness, anxiety, depression, paresthesias, Hypersensitivity to retinoids, pregnancy and
Vesanoid Acute promyelocytic leukaemia Maintenance: 45 mg/m2 daily for 2 weeks every 3 risk of toxicity. Use together with vitamin A
Capsule levels. To be used with caution in pre-existing confusion, pseudotumour cerebri, lactation
months. Refer to protocols supplements may result in increase in toxicity.
hypertriglyceridaemia, diabetes mellitus, obesity. gastrointestinal bleeding, abdominal pain,
Avoid ethanol. Exposure to paclitaxel result in
Anticipate and treat retinoic acid syndrome diarrhoea, constipation, retinoic acid syndrome,
increased risk of paclitaxel toxicity. Tranexamic
bone pain, muscle pain, joint pain, increase in
Acid may result in increased risk of thrombosis
serum triglycerides and cholesterol
Ketoconazole, fluconazole, itraconazole,
contraceptives; increased alprazolam serum
concentrations and potential alprazolam toxicity
(sedation, slurred speech, CNS depression).
Omeprazole, erythromycin, clarithromycin,
cimetidine; benzodiazepine toxicity (CNS
depression, ataxia, lethargy). Sertraline,
Drowsiness, blurred vision, coordination
increased risk of psychomotor impairment and
disorder, gastrointestinal disturbance, agitation,
Avoid operating vehicles or machinery, abuse prone sedation. Fluoxetine, increased risk of
lightheadedness, dry mouth, depression,
0.25 - 0.5 mg 3 times daily (elderly or delibitated 0.25 patient, pregnancy and breastfeeding, renal or Hypersensitivity to benzodiazepines, acute alprazolam toxicity (somnolence, dizziness,
headache, confusion, hypotension, syncope,
Alprazolam 0.25 mg Tablet Xanax Anxiety disorders mg 2-3 times daily), increased if necessary to a total hepatic dysfunction, elderly patients, obesity, narrow angle glaucoma, concomitant use of ataxia, slurred speech, hypotension,
tachycardia, seizures, respiratory depression,
dose of 3 mg/day. Not recommended for children untreated open angle glaucoma, impaired pulmonary ketoconazole/ itraconazole, CNS depression psychomotor impairment). Fluvoxamine,
coma, constipation, diarrhoea, nausea, vomiting,
function. Prolonged use can lead to dependence increased risk of CNS side effects. Ritonavir,
insomnia, nasal congestion, rigidity, increased
increased plasma concentrations of alprazolam
salivation, dermatitis, sedation
and enhanced alprazolam effects.
Antihistamine/decongestant combinations,
antipsychotic, ethanol, mirtazapine,
phenothiazines, venlafaxine (increased risk of
CNS depression, psychomotor impairment),
sedative/hypnotics, tricyclic antidepressants
(CNS depression)
Alprazolam 0.5 mg Tablet Xanax Anxiety disorders mg 2-3 times daily), increased if necessary to a total hepatic dysfunction, elderly patients, obesity, narrow angle glaucoma, concomitant use of ataxia, slurred speech, hypotension,
(CNS depression)
Alprazolam 1 mg Tablet Xanax Anxiety disorders mg 2-3 times daily), increased if necessary to a total hepatic dysfunction, elderly patients, obesity, narrow angle glaucoma, concomitant use of ataxia, slurred speech, hypotension,
(CNS depression)
For treatment of congenital heart diseases which are 0.05 - 0.1 mcg/kg/min by continuous IV infusion, then Concurrent anticoagulants, neonates with bleeding Bradycardia, fever, hypotension, tachycardia,
Alprostadil 500 mcg/ml Injection Prostin VR Neonates with respiratory distress syndrome Heparin
ductus arteriosus dependent decreased to lowest effective dose tendencies, spinal cord injury neonatal apnoea, seizures
Aluminium Acetate 5% Lotion - Weeping eczema Use undiluted freshly prepared as soaks Broken or irritated skin Hypersensitivity Hypersensitivity to any component Not known
Major: phosphate binders and citrates may
increase serum aluminum concentrations
Hypophosphataemia, porphyria, end-stage renal
(toxicity);sodium polystyrene sulfonate (systemic
600 mg- 1.2 g 4 times daily and at bedtime or as Chronic renal failure, may cause phosphate disease. Risk of developing hyperaluminemia
Aluminium Hydroxide 600 mg Tablet Alutab Dyspepsia, hyperphosphataemia Constipation alkolosis). Minor: Affects absorption of
required depletion and encephalopathy (fatalities have been
tetracyclines, penicillins, sulfonamides, quinidine,
reported)
iron, digoxin, indomethacin, naproxen,
phenylbutazon
Oedema of ankles, livedo reticularis, depression,
Seizure disorder, psychiatry disorder, recurrent hallucination, nausea, vomiting, dizziness, Alcohol, methyldopa, metoclopramide,
Initial dose: 100 mg daily and is increased to 100 mg
eczema, gastric ulceration. Patients with insomnia, blurred vision, dry mouth. Seizures, Hypersensitivity to amantadine products, domperidone, antipsychotic, antimuscarinics.
twice daily (not later than 4 p.m.) after a week. Elderly
Amantadine HCl 100 mg Capsule Symmetrel Parkinson's disease cardiovascular or liver disease, impaired renal psychosis, confusion, ataxia, heart failure, pregnancy, lactation, epilepsy, history of gastric Enhances the adverse effects of antimuscarinics
over 65 years: less than 100 mg or 100 mg at intervals
function. Elderly. Withdrawal of the drug should be depression, orthostatic hypotension, blood ulceration, severe renal impairment and levodopa. Central nervous system
of more than 1 day
gradual dyscrasias, urinary retention, irritability, stimulants, drugs that raise urinary pH
gastrointestinal disturbances
Potentiation of toxicity in combination with loop
ADULT: (IM or IV): 15 mg/kg/day 8 - 12 hourly for 7 - 10
Myasthenia gravis, renal impairment, pregnancy and diuretics, cephalothin, vancomycin, cyclosporin.
days. Maximum: 1.5 g/day. CHILD: 15 mg/kg/day 8 - 12 Ototoxicity and nephrotoxicity, rarely skin rash,
lactation. Tinnitus or vertigo may be indications of Prolongs action of neuromuscular blockers.
Amikacin 250 mg/2 ml Injection Amikin Infections due to susceptible organisms hourly. Maximum: 1.5 g/day. Neonates: Initial loading fever, paraesthesia, athralgia, anaemia, Hypersensitivity to aminoglycosides
vestibular injury and impending bilateral irreversible Increased risk of respiratory depression with
dose of 10 mg/kg followed by 7.5 mg/kg/day 12 hourly. hypotension
damage either halothane, methoxyflurane &
Maximum 15mg/kg/day
neuromuscular blockers
Potentiation of toxicity in combination with loop
ADULT: (IM or IV): 15 mg/kg/day 8 - 12 hourly for 7 - 10
Myasthenia gravis, renal impairment, pregnancy and diuretics, cephalothin, vancomycin, cyclosporin.
days. Maximum: 1.5 g/day. CHILD: 15 mg/kg/day 8 - 12 Ototoxicity and nephrotoxicity, rarely skin rash,
lactation. Tinnitus or vertigo may be indications of Prolongs action of neuromuscular blockers.
Amikacin 500 mg/2 ml Injection Amikin Infections due to susceptible organisms hourly. Maximum: 1.5 g/day. Neonates: Initial loading fever, paraesthesia, athralgia, anaemia, Hypersensitivity to aminoglycosides
vestibular injury and impending bilateral irreversible Increased risk of respiratory depression with
dose of 10 mg/kg followed by 7.5 mg/kg/day 12 hourly. hypotension
damage either halothane, methoxyflurane &
Maximum 15mg/kg/day
neuromuscular blockers
Angiotensin converting enzyme inhibitors:
postural hypotension (first dose).
Diabetes mellitus. Electrolyte imbalance,
Carbamazepine: hyponatraemia.
concomitant use of other diuretics can result in
Chlorpropamide: decreased chlorpropamide
i) Initially 1 - 2 tab daily adjusted according to response. hyponatraemia and hypochloremia as well as Hypersensitivity to hydrochlorothiazide/amiloride
Amiloride HCl 5 mg & i) Diuretic as an adjunct to the management of Hyperkalaemia, rash, dizziness, headache, effectiveness. Digitalis: digitalis toxicity (nausea,
Moduretic Max : 4 tabs daily. ii) 1 -2 tabs daily as a single or increases in BUN levels. This is more frequent in or sulfonamides, hyperkalaemia, anuria, renal
Hydrochlorothiazide 50 mg Tablet oedematous states ii) Hypertension asthenia vomiting, arrhythmias). Corticosteroids:
divided dose patients with hepatic cirrhosis and ascites, metabolic failure
hypokalaemia and subsequent cardiac
alkalosis or those with resistant oedema. Metabolic
arrhythmias. NSAIDs: decreased diuretic and
or respiratory acidosis
antihypertensive efficacy. Propranolol:
hyperglycaemia, hypertriglyceridemia
Dose to be individualised. ADULT usually 500-2000 ml Patients with inborn errors of amino acid
Gastrointestinal upset, flushing, sweating,
Amino Acids Injection Vamin Source of amino acids in patients needing IV nutrition by IV. ADULT usual requirement for amino acid: 1-2 Liver disease, renal impairment metabolism, irreversible liver damage, severe Not known
thrombophlebitis
g/kg/day uraemia without dialysis
Patients with inborn errors of amino acid
Source of amino acids and electrolytes in patients Dose to be individualised. ADULT usual requirement for Gastrointestinal upset, flushing, sweating,
Amino Acids with Electrolytes Injection - Liver disease, renal impairment metabolism, irreversible liver damage, severe Not known
needing IV nutrition amino acid 1-2 g/kg/day thrombophlebitis
uraemia without dialysis
Amino Acids with Glucose with Source of amino acids, carbohydrate and electrolytes Dose to be individualised. ADULT usual requirement for Hyperammonemia, encephalopathy, cholestasis,
Liver disease, renal impairment metabolism, irreversible liver damage, severe Not known
Electrolytes Injection in patients needing IV nutrition amino acid 1-2 g/kg/day, carbohydrate 4-6 g/kg/day thrombophlebitis
Amino Acids with Glucose without Source of amino acids and carbohydrate in patients Dose to be individualised. ADULT usual requirement for Hyperammonemia, encephalopathy, cholestasis,
- Liver disease, renal impairment metabolism, irreversible liver damage, severe Not known
Electrolytes Injection needing IV nutrition amino acid 1-2 g/kg/day, carbohydrate 4-6 g/kg/day thrombophlebitis
Dose to be individualised. ADULT: 500 - 2000 ml daily
Amino Acids, Glucose and Lipid with Source of amino acids, carbohydrate, lipid and given by IV. ADULT usual requirement for amino acid 1- Gastrointestinal upset, flushing, sweating,
- Liver disease, renal impairment metabolism, irreversible liver damage, severe Not known
Electrolytes Injection electrolytes in patients needing IV nutrition 2 g/kg/ day, carbohydrate 4-6 g/kg/day, lipid 2-3 thrombophlebitis
g/kg/day
Drowsiness, lethargy, ataxia, fever, skin rashes
and gastrointestinal disturbances. Bone-marrow
Increased metabolism of synthetic
0.5 - 1 g/day. With hydrocortisone 30 mg/day or Monitor blood pressure, adrenal and thyroid function. depression with leucopenia, thrombocytopenia,
Only for the treatment of hormone-responsive breast Porphyria, pregnancy, hypersensitivity to glucocorticoids, warfarin and other oral
Aminoglutethimide 250 mg Tablet Orimetene cortisone acetate 37.5 mg/day to prevent adrenal Periodic blood counts. May impair ability to drive and agranulocytosis or severe pancytopenia. Adrenal
cancer aminoglutethimide anticoagulants, theophylline,
insufficiency operate machinery. Not recommended in lactation insufficiency and other endocrine disturbances
medroxyprogesterone and oral antidiabetics
including hypothyroidism and virilisation.
Orthostatic hypotension
Hyperthyroidism, glaucoma, diabetes mellitus,
angina pectoris, pulmonary, cardiovascular, renal or
hepatic diseases. Pregnancy, children and elderly.
Deteriorating acute asthma not previously treated with Active peptic ulcer disease, seizure disorders,
theophylline, by slow IV injection over 20 minutes 250 - cardiac arrhythmias (not including Tachycardia, palpitations, nausea and other
Azole antifungals, ciprofloxacin, clarithromycin,
500 mg (5 mg/kg), then as for acute severe asthma. bradyarrhythmias). Patients with migraine gastrointestinal disturbances, headache, CNS
Hypersensitivity to theophylline or derivatives, erythromycin : increased risk of theophylline
Aminophylline 25 mg/ml Injection - Reversible airways obstruction, acute severe asthma Acute severe asthma by IV infusion : 500 mcg/kg/hour, headaches may experience an increased frequency stimulation, insomnia, arrythmias, also allergy to
hypersensitivity to ethylenediamine toxicity. Caffeine : increased caffeine level.
adjusted according to plasma-theophylline of headaches. Patients with congestive heart failure, ethylenediamine which can cause urticaria,
Halothane : increased risk of arrthmia
concentration. CHILD : 6 month - 9 years : 1 cor pulmonale, prolonged fever, hypothyroidism, erythema, and exfoliative dermatitis
mg/kg/hour, 10 - 16 years : 800 mcg/kg/hour liver disease, sepsis with multi-organ failure, and
shock may require reduced theophylline dosage.
Concommitant medication use which results in
reduced theophylline clearance
Acute myocardial infarction, sino-atrio, block AV or
Reversible corneal microdeposits; colored halos. Antiarrhythmics, beta-blockers, stimulating
Initial infusion of 5mg/kg via large venous access over other severe conduction disorder ( unless the patient Cardiogenic shock, hypersensitivity to
Hyper or hypothyroidism. Rarely; laxatives, diuretics inducing hypokalaemia,
Arrhythmias when other drugs are contraindicated or 20-120 minutes with ECG monitoring; subsequent has a pacemaker),severe hypotension,severe amiodarone, second or third degree AV block (if
Amiodarone 150mg/3 ml Injection Cordarone photosensitization and pigmentation. Reversible systemic corticosteroids, tetracosactide,
ineffective infusion given if necessary according to response up to respiratory failure, bradycardia, no pacemaker is present). Severe sinus
diffuse interstitial pneumopathy or peripheral amphotericin B, digitalis, anticoagulants,
a maximum of 1.2 g in 24 hours cardiomegaly,corneal microdeposits (impaired bradycardia and severe sinus-node dysfunction
neuropathy phenytoin, general anaesthetic, ciclosporin
vision)
Acute myocardial infarction, sino-atrio, block AV or Reversible corneal microdeposits; colored halos. Antiarrhythmics, beta-blockers, stimulating
200 mg 3 times daily for 1 week, then reduced to 200 Cardiogenic shock, hypersensitivity to
other severe conduction disorder (unless the patient Hyper or hypothyroidism. Rarely; laxatives, diuretics inducing hypokalaemia,
mg twice daily for another week. Maintenance dose, amiodarone, second or third degree AV block (if
Amiodarone 200 mg Tablet Cordarone Arrhythmias has a pacemaker),severe hypotension,severe photosensitization and pigmentation. Reversible systemic corticosteroids, tetracosactide,
usually 200 mg daily or the minimum required to control no pacemaker is present). Severe sinus
respiratory failure,bradycardia, cardiomegaly, diffuse interstitial pneumopathy or peripheral amphotericin B, digitalis, anticoagulants,
the arrhythmia bradycardia and severe sinus-node dysfunction
corneal microdeposits (impaired vision) neuropathy phenytoin, general anaesthetics, ciclosporin
Barbiturate, phenytoin, carbamazepine,

cimetidine, amphetamines, antiarrhythmics, class
Ia and III, anticholinergics, antihistamines, beta 2
Dry mouth, constipation, nausea, vomiting,
agonists, benzodiazepines, systemic carbonic
Cardiac disease, hyperthyroidism, impaired hepatic urinary retention, blurred vision, drowsiness,
anhydrase inhibitors, central alpha 2 agonists,
Initially 75 mg. ADULT and ELDERLY : 30 - 75 mg daily and renal function, urinary retention, history of dizziness, tachycardia, increased appetite,
Hypersensitivity to drug/class. Immediate cholinergic agents, clozapine, intranasal
in divided doses or as a single dose at bedtime, seizures, glaucoma, suicide risk, pregnancy, confusion, seizures, myocardial infarction,
Amitriptyline HCl 25 mg Tablet Laroxyl Depression recovery phase after myocardial infarction, heart decongestants, flumazenil, halothane, lithium,
increase gradually as necessary to 150 - 200 mg. lactation, elderly, phaeochromocytoma, history of stroke, agranulocytosis, thrombocytopenia, rash
block, mania. MAOI use within the last 14 days MAOIs, methylphenidate, metoclopramide,
CHILD under 16 years are not recommended mania, phychoses, angle-closure glaucoma, and hypersensitivity reactions, blood sugar
muscle relaxants, nitrates, opiates,
concurrent anticonvulsive therapy, anaesthesia changes, endocrine side effects, impotence,
antipsychotics, phenytoin, protease inhibitors,
menstrual irregularities, bone marrow depression
sedatives/hypnotics, SSRIs, indirect/mixed
sympathomimetics, cimetidine, fluoxetine,
clonidine
Nasopharyngitis, flu, headache, oedema,
peripheral oedema, fatigue, flushing, asthenia,
Risk of hypotension in sodium or volume depleted vertigo, tachycardia, palpitations, orthostatic
patient, beta blocker withdrawal should be gradual. hypotension, cough, pharyngolaryngeal pain,
Doses range from amlodipine besylate 5 mg/valsartan
Severe renal impairment, dialysis. Unilateral/ gastrointestinal disturbances, rash, erythema,
160 mg to amlodipine besylate 10 mg/valsartan 320 mg Pregnancy and lactation, hypersensitivity to Potassium supplement. Potassium-sparing
Amlodipine 10 mg and Valsartan 160 Essential hypertension in patients whose blood bilateral renal stenosis, stenosis to a solitary kidney, joint swelling, back pain, arthralgia. Rare:
Exforge ORALLY once daily, with dose titration occurring every amlodipine, valsartan, or any component of the diuretic, potassium containing salt substitutes or
mg Tablet pressure is not adequately controlled by monotherapy after recent kidney transplantation, hepatic Hypersensitivity. Amlodipine: Gastritis, gingival
1 to 2 weeks if necessary. MAX amlodipine besylate 10 product other drugs that may increase potassium level
impairment, biliary obstructive disorders. Aortic or hyperplasia, gynaecomastia, leucopaenia,
mg/valsartan 320 mg
mitral stenosis, obstructive hyperthrophic myalgia, pancreatitis, hepatitis,
cardiomyopathy thrombocytopaenia, vasculitis. Valsartan:
Neutropaenia, increases in creatinine, serum
potassium and BUN
Angina (exacerbation) during initiation of treatment;
with dosage increases; during beta-blocker
withdrawal; taper slowly prior to calcium channel Hypersensitivity to amlodipine, symptomatic
Headache, dizziness, gingival hyperplasia, Cyclosporin, fluconazole, itraconazole,
Amlodipine 10 mg Tablet Norvasc Hypertension 5 mg once daily. Max: 10 mg blocker therapy. Aortic stenosis (reduced myocardial hypotension, persistent dermatologic reactions,
tachycardia, peripheral oedema ketoconazole, vardenafil
oxygenation with drug-induced hypotension), congestive heart failure
congestive heart failure, pregnancy, hepatic
impairment
Nasopharyngitis, flu, headache, oedema,
peripheral oedema, fatigue, flushing, asthenia,
Risk of hypotension in sodium or volume depleted vertigo, tachycardia, palpitations, orthostatic
patient, beta blocker withdrawal should be gradual. hypotension, cough, pharyngolaryngeal pain,
Doses range from amlodipine besylate 5 mg/valsartan
Severe renal impairment, dialysis. Unilateral/ gastointestinal disturbances, rash, erythema,
160 mg to amlodipine besylate 10 mg/valsartan 320 mg Pregnancy and lactation, hypersensitivity to Potassium Supplement. Potassium-sparing
Amlodipine 5 mg and Valsartan 160 Essential hypertension in patients whose blood bilateral renal stenosis, stenosis to a solitary kidney, joint swelling, back pain, arthralgia. Rare:
Exforge ORALLY once daily, with dose titration occurring every amlodipine, valsartan or any component of the diuretic, potassium containing salt substitutes or
mg Tablet pressure is not adequately controlled by monotherapy after recent kidney transplantation, hepatic Hypersensitivity. Amlodipine: Gastritis, gingival
1 to 2 weeks if necessary. MAX amlodipine besylate 10 product other drugs that may increase potassium level
impairment, biliary obstructive disorders. Aortic or hyperplasia, gynaecomastia, leucopaenia,
mg/valsartan 320 mg
mitral stenosis, obstructive hyperthrophic myalgia, pancreatitis, hepatitis,
cardiomyopathy thrombocytopaenia, vasculitis. Valsartan:
Neutropaenia, increases in creatinine, serum
potassium and BUN
Angina (exacerbation) during initiation of treatment;
with dosage increases; during beta-blocker
withdrawal; taper slowly prior to calcium channel Hypersensitivity to amlodipine, symptomatic
Headache, dizziness, gingival hyperplasia, Cyclosporin, fluconazole, itraconazole,
Amlodipine 5 mg Tablet Norvasc Hypertension 5 mg once daily. Max: 10 mg blocker therapy. Aortic stenosis (reduced myocardial hypotension, persistent dermatologic reactions,
tachycardia, peripheral oedema ketoconazole, vardenafil
oxygenation with drug-induced hypotension), congestive heart failure
congestive heart failure, pregnancy, hepatic
impairment
Ammonium Bicarbonate, Tincture If consumed in very large dose can cause
Expect Stimulant Cough 10 - 20 ml 3 times daily Can be irritant to mucous membrane Hepatic or renal impaiment Not known
Ipecac, etc Mixture nausea and vomiting
Apply to affected nail once or sometimes twice a week
after filling and cleansing, allow to dry, treat finger nail Avoid contact with eyes, previous hypersensitivity or
Amorolfine 5 % Nail Lacquer Loceryl Fungal nail infections Slight transient burning sensation Hypersensitivity to amorolfine Not known
for 6 months, toe nail for 9 - 12 months (review at intolerance to other topical antifungal agents
intervals of 3 months)
Hypersensitivity to penicillins, possible cross
Amoxicillin & Clavulanate 228 mg/5 ml Moderate infections: CHILD 7 - 12 year: 10 ml, 2 - 6 Diarrhoea, pseudomembraneous colitis, sensitivity with other β-lactams. History of Aminoglycosides, anti-coagulants, oral
Augmentin Infections caused by susceptible organisms Renal impairment, severe hepatic dysfunction
Syrup year: 5 ml. Severe infections: 2 - 6 year: 10 ml indigestion, GI upsets, increased liver enzyme penicillin-associated cholestatic jaundice or contraceptives, methotrexate
hepatic dysfunction
Diarrhoea, pseudomembraneous colitis, GI
Infections caused by susceptible organisms. upsets, increased liver enzyme, urticaria and Hypersensitivity to penicillins, possible cross
CHILD less than 3 months: 30mg/kg 12 hourly. 3
Amoxicillin 1 g & Clavulanate 200 mg Respiratory tract, skin, soft tissue, GUT infection, Pregnancy, breast-feeding, renal or liver failure, erythematous multiforme, Steven-Johnson sensitivity with other â-lactams. History of Aminoglycosides, anti-coagulants, oral
Augmentin months - 12 years: 30mg/kg 6 - 8 hourly. ADULT: 1.2 g
Injection septicaemia, peritonitis, post-operative infection & pseudomembranous colitis syndrome, toxic epidermal necrolysis, exfoliative penicillin-associated cholestatic jaundice or contraceptives, methotrexate
by IV or intermittent infusion 6 - 8 hourly
osteomyelitis dermatitis, transient leucopenia, hepatic dysfunction
thrombocytopenia, haemolytic anaemia
Infections caused by susceptible strains of gram ADULT: 250 - 500 mg 3 times daily. CHILD: 20 - 40 Hypersensitivity to cephalosporins, renal or hepatic Diarrhoea, indigestion, urticarial or erythematous
Amoxicillin 250 mg Capsule Hypersensitivity to penicillins Aminoglycosides, oral contraceptives
positive and gram negative organisms mg/kg/day in divided doses 8 hourly impairment, superinfection rash, hepatitis, cholestatic jaundice
Diarrhoea, indigestion, nausea, vomiting,
candidiasis, rash, pseudomembranous colitis,
Infections due to beta-lactamase producing strain Hypersensitivity to penicillins, possible cross
ADULT & CHILD more than 12 years: Mild to moderate hepatitis, cholestatic jaundice, crystalluria,
Amoxicillin 500 mg & Clavulanate 125 where amoxicillin alone is not appropriate. Respiratory sensitivity with other β-lactams. History of Aminoglycosides, anticoagulants, oral
infections: 625 mg twice daily. Severe infections: 1 g Renal or hepatic impairment, pregnancy erythema multiforme, Stevens-Johnson
mg Tablet tract, skin, soft tissue, GUT infection, septicaemia, penicillin-associated cholestatic jaundice/hepatic contraceptives, methotrexate
twice daily syndrome, toxic epidermal necrolysis, reversible
peritonitis, post-operative infection & osteomyelitis dysfunction
leucopaenia, thrombocytopaenia, haemolytic
anaemia, CNS disturbances
Diarrhoea, pseudomembraneous colitis,
Infections caused by susceptible organisms. gastrointestinal upsets, increased liver enzyme, Hypersensitivity to penicillins, possible cross
CHILD less than 3 months: 30mg/kg 12 hourly. 3
Amoxicillin 500 mg and Clavulanate Respiratory tract, skin, soft tissue, GUT infection, Pregnancy, breast-feeding, renal or liver failure, urticaria and erythematous multiforme, Steven- sensitivity with other beta-lactams. History of Aminoglycosides, anti-coagulants, oral
Augmentin months - 12 years: 30 mg/kg 6 - 8 hourly. ADULT: 1.2 g
100 mg Injection septicaemia, peritonitis, post-operative infection and pseudomembranous colitis Johnson syndrome, toxic epidermal necrolysis, penicillin-associated cholestatic jaundice or contraceptives, methotrexate
by IV or intermittent infusion 6 - 8 hourly
osteomyelitis exfoliative dermatitis, transient leucopenia, hepatic dysfunction
thrombocytopenia, haemolytic anaemia
CHILD less than 10 years: 125 - 250 mg 8 hourly.
Amoxicillin Trihydrate 125 mg/5 ml Infections caused by susceptible strains of gram Hypersensitivity to cephalosporins, renal or hepatic Diarrhoea, indigestion, urticarial or erythematous
- CHILD less than 20 kg: 20 - 40 mg/kg/day in 3 - 4 Hypersensitivity to penicillins Aminoglycosides, oral contraceptives
Syrup positive and gram negative organisms impairment, superinfection rash, hepatitis, cholestatic jaundice
divided doses
Nausea and vomiting, anaemia, Cyclosporin, digitalis glycosides, non-
Amphotericin B 0.15% Eye Drops - Fungal infection of the cornea 1 drop hourly or 2 hourly Renal impairment Hypersensitivity to Amphotericin B
thrombocytopenia depolarizing neuromuscular blockers
Nausea and vomiting, anaemia, Cyclosporin, digitalis glycosides, non-
Amphotericin B 0.25% Eye Drops - Fungal infection of the cornea 1 drop hourly or 2 hourly Renal impairment Hypersensitivity to Amphotericin B
thrombocytopenia depolarizing neuromuscular blockers
Fever, headache, anorexia, weight loss, GI
ADULT: 0.25 mg/kg/day by IV infusion, gradually disturbances, malaise, epigastric pain,
Avoid rapid infusion, renal impairment. Hepatic &
increase if tolerated to 1 mg/kg/day. Maximum in dyspepsia, generalized pain, anaemia, abnormal Corticosteroids, nephrotoxic antibiotics and
Amphotericin B 50 mg Injection Fungizone Systemic fungal infections renal function tests, blood count & plasma electrolyte Hypersensitivity
severe cases: 1.5 mg/kg daily or on alternate days. For renal function. Rarely cardiovascular toxicity, antineoplastics
monitoring are required. Pregnancy, lactation
neonates, lower doses are recommended haematologic reactions, neurologic reactions,
liver failure
ADULT: 375 - 750 mg bd. CHILD more than 30 kg- Overgrowth of non-susceptible organism. Check
Ampicillin Sodium & Sulbactam GI disturbances, phlebitis, skin rashes, itching,
Unasyn Susp. Treatment of susceptible bacterial infections adult dose, less than 30 kg: 25 - 50 mg/kg/day in 2 periodically for organ system dysfunction during History of allergic reaction to any penicillins Not known
Sodium 250 mg/5 ml Suspension blood disorders, anaphylaxis and superinfection
divided doses prolong therapy
Overgrowth of non-susceptible organism. Check
Ampicillin Sodium & Sulbactam ADULT & CHILD more than 30 kg: 375 - 750 mg twice GI disturbances, phlebitis, skin rashes, itching,
Unasyn Treatment of susceptible bacterial infections periodically for organ system dysfunction during History of allergic reaction to any penicillins Not known
Sodium 375 mg Tablet daily. Maximum: 3 g daily blood disorders, anaphylaxis and superinfection
prolong therapy
ADULT: 1.5 - 12 g/day in divided doses 6 - 8 hourly.
Maximum: 4 g Sulbactam. CHILD: 150-300 mg/kg/day
Ampicillin Sodium 1g & Sulbactam 6 - 8 hourly. Prophylaxis of surgical infections: 1.5 - 3 g GI disturbances, phlebitis, skin rashes, itching, Concurrent use with oral contraceptives may
Unasyn 1.5g Treatment of susceptible bacterial infections periodically for organ system dysfunction during History of allergic reaction to any penicillins
Sodium 500mg Injection at induction of anaesthesia. May be repeated 6 - 8 blood disorders, anaphylaxis and superinfection result in decreased contraceptive effectiveness
prolong therapy
hourly. NEONATES: First week of life, 75mg/kg/day in
divided doses every 12 hour
ADULT: 1.5 - 12 g/day in divided doses 6 - 8 hourly.
Ampicillin Sodium 500 mg & Maximum: 4 g Sulbactam per day. CHILD: 150- GI disturbances, phlebitis, skin rashes, itching, Concurrent use with oral contraceptives may
Unasyn 750 mg Treatment of susceptible bacterial infections periodically for organ system dysfunction during History of allergic reaction to any penicillins
Sulbactam Sodium 250 mg Injection 300mg/kg/day 6 - 8 hourly. Prophylaxis: 1.5 -3 g at blood disorders, anaphylaxis and superinfection result in decreased contraceptive effectiveness
prolong therapy
induction of anaesthesia. May be repeated 6 - 8 hourly
250 - 500 mg IM/IV every 4 - 6 hours. Maximum: 400 Hypersensitivity to cephalosporins. Chronic
GI disturbances, skin rashes, pruritis, urticartia, Excretion impaired by probenecid. Increased risk
Treatment of susceptible bacterial infections (non beta- mg/kg/day. Meningitis: 2 g 6 hourly. CHILD: 150 treatment requires assessment of renal, hepatic&
Ampicillin Sodium 500 mg Injection Penbritin fever, anaphylaxis, blood disorders, Hypersensitivity to penicillins of skin rashes with allopurinol. May decrease
lactamase-producing organisms); meningitis mg/kg/daily IV in divided doses. Usual children dose haematopoietic functions. Renal impairment,
superinfection effectiveness of oral contraceptives and atenolol
less than 10 years, half adult dose lymphatic leukaemia
CHILD: 50 - 100 mg/kg/day 4 times daily. Under 1 year:
Ampicillin Trihydrate 125 mg/5 ml Treatment of susceptible bacterial infections (non beta- Hypersensitivity to cephalosporins. Severe renal Diarrhoea, indigestion, nausea, vomiting,
Penbritin 62.5 - 125 mg 4 times daily, 1 - 10 years: 125 - 250 mg Hypersensitivity to penicillins Bacteriostatic drugs, anticoagulants
Suspension lactamase-producing organisms) dysfunction occasionally rashes
4 times daily
Hyperlipidemia, moderate to severe hepatic
Hot flashes, asthenia, peripheral oedema,
impairment, severe impairment of renal function
Treatment of hormone responsive metastatic or locally vaginal bleeding, deep vein thrombosis, Hypersensitivity to anastrazole, pregnancy. Not
Anastrozole 1 mg Tablet Arimidex 1 mg daily (creatinine clearance less than 20 mL/min). Lowers Oestrogens, tamoxifen
advanced breast cancer after failure of tamoxifen arthralgia, backpain, cough, dypsnea, headache, indicated for premenopausal women
circulating oestrogen levels which may cause a
nausea, rash, hypercholesterolaemia
reduction in bone mineral density
Insufficiently controlled Diabeted Mellitus, recent
Myocardial Infarction, severe organic heart or
vascular disorders, hyperthyroidism, Diarrhoea, hypokalemia, hypomagnesemia,
Ciclosporine; Anidulafungin steady state AUC
phaeochromocytoma, prostatic hypertrophy, bladder- thrombocytopenia, coagulopathy, convulsion,
Treatment of invasive candidiasis, including may be slightly increased. No dosage
neck obstruction, cystic fibrosis, predisposition to headache, increased gamma- Hypersensitivity to anidulofungin or other
Anidulafungin 100mg Injection Eraxis® candidemia in adults when intolerance or resistance to 200 mg single loading dose on day 1, then 100 mg daily adjustment is needed. Antifungal agents:
narrow-angle glaucoma. Pregnancy, lactation. glutamyltransferase, blood alkaline phosphatase, antifungals of echinocandin class eg caspofungin
Amphotericin B or Fluconazole Antifungal agents may diminish the therapeutic
Infusion rate should not exceed 1.1 mg/min. Hepatic aspartate aminotransferase and alanine
effect
dysfunction, significant, worsening hepatic failure, aminotransferase, rash, pruritus
hepatitis/clinically significant hepatic abnormalities
have occurred
Hypersensitivity to any of the components of

product, dry eyes; especially keratoconjunctivitis
ADULT : Instill 1 drop, 3 - 4 times daily, into the lower sicca, risk of narrow angle glaucoma, receiving
Antazoline HCl, Tetrahydrozoline HCl Hay fever, conjunctivitis, allergic conjunctivitis, vernal Transient irritation may occur immediately after Mild burning sensation, headache, and
Spersallerg eyelid. CHILD 2 - 12 years : Instill 1 drop daily or twice monoamine oxidase inhibitors or within 14 days Not known
and Benzalkonium Cloride Eye Drops keratoconjunctivitis and eczematosa instillation sleepiness, tachycardia, blurred vision
daily of its treatment, children under two years of age;
due to the greater incidence of systemic
absorption and effects
Prevention of Rh(D) sensitisation by IM injection to 50 - 100 mcg within 72 hours after incompatible blood
Anti RhD Gamma Globulin 250 mcg/2 Never administer by IV or to infant. IgA deficiency. Pain at injection site. Slight temperature
Rhogam rhesus-negative woman after delivery of rhesus- transfusion: 25 mcg (125 units) per ml transfused RhD positive mother Live virus vaccines
ml Injection (500 units=100 mcg) Hypersensitivity to thiomersal or human Ig elevation
positive infant blood, up to 1000 mcg
i) To be used when conventional anti-rejection therapy
is not successful ii) Treatment of aplastic anaemia not
responding to oxymethalone after 3 months, in which
Perform test dose, prophylactic platelet transfusion
there is persistent pancytopenia with repeated attacks
10 - 30 mg/kg body weight daily. Slow IV infusion (over before and after infusion. Sodium and fluid overload. Severe and unremitting thrombocytopenia or
Antilymphocyte/Antithymocyte of septicaemia and bleeding. iii) Severe aplastic
Atgam at least 4 hours) diluted in 250 - 500 ml Normal Saline. Monitor for allergic reactions and serum sickness leucopenia, generalized rash, tachycardia, Hypersensitivity, acute viral illness. Live vaccines, increased risk of infection.
Immunoglobulin (from Horse) Injection anaemia with the following parameters: a) Granulocyte
For Graft versus host disease treatment:40 mg/kg/day Monitor for signs of leukopenia, thrombocytopenia or dyspnoea, hypotension, anaphylaxis.
less than 0.5x109/L b) Platelet less than 20x109/L c)
concurrent infection. Perform skin testing
Reticulocyte less than 20x109/L iv) As a conditioning
regime prior to transplant. v) Graft-versus-host disease
treatment
Allergy to neomycin. Prior systemic reaction to Severe febrile infection, acute disease,
Antirabies Immunoglobulin (Human) 20 iu/kg; half by IM and half by infiltration around the Minor local reactions, systemic reactions,
Imogam Rabies Treatment of rabies, post-exposure human immunoglobulin preparation, isolated progressive chronic disease, hypersensitivity to Corticosteroids and immunosuppressant
300 iu/2ml wound hypersensitivity reaction, neuropathy
immunoglobulin A deficiency any of the ingredients of the vaccine
Monitor for allergic reactions, perform test dose,
prophylactic platelet transfusion before and after
i) To be used when conventional anti-rejection therapy
infusion and monitor fluid overload, discontinue
is not successful (patients who do not respond to horse Leucopenia, nausea, vomiting, dizziness,
immediately & permanently withdraw in case of
serum) ii) Treatment of aplastic anaemia not headache, fever, chills hypotension, tachycardia,
Antithymocyte Immunoglobulin (from anaphylactic reaction. Monitor blood cell count for 2
responding to oxymetholone after 3 months, in which Antirejection therapy: 2.5-5 mg/kg/day dyspnoea, pain at infusion site, peripheral Hypersensitivity Live vaccines
rabbit) Injection week after end of therapy. Monitor platelet count in
there is persistent pancytopenia with repeated attacks thrombophlebitis, thrombocytopenia,
patient with initial thrombocytopenia & especially in
of septicaemia and bleeding. iii) Severe aplastic neutropenia, serum sickness
heart transplant patients. Premed with
anaemia. iv) Graft-versus-host disease treatment
corticosteroids & antihistamines may prevent or
alleviate 1st dose syndrome. Pregnancy & lactation
Chest pain, hypotension, chills, nervousness,
cellulitis, bruising, pruritus, rash, urticaria,
anorexia, nausea, coagulation disorder, back Hypersensitivity to any component of the
Reconstitute content for the vial with 5 ml sterile
Antivenene Malaysian Pit Viper Sensitivity testing should be performed before the pain, circumoral paraesthesia, general formulation, unless the benefits outweigh the
- Bitten by pit viper pyrogen-free distilled water. Administer by IV infusion Not known
Injection administration paraesthesia, myalgia, asthma, cough, risks and appropriate management for
200 ml of normal saline over a period of 1 - 2 hours
dyspnoea, sputum increased, wheezing, allergic anaphylaxis is available
reaction, serum sickness, subcutaneous nodule,
wound infection, anaphylaxis, serum sickness
The reconstituted antivenin should be given by slow Anaphylaxis with hypotension, dyspnea, Hypersensitivity to any component of the
Respiratory support maybe essential. Sensitivity
intravenous infusion, approximately urticaris, Immune hypersensitivity reaction , formulation, unless the benefits outweigh the
Antivenene Serum (Cobra) Injection - Treatment for cobra bites testing should be performed before the Not known
2ml/min.Subsequent dose can be given every 12 hours shock, transfusion reaction due to serum protein risks and appropriate management for
administration
according to the clinical symptoms reaction ,serum sickness anaphylaxis is available
Anaphylaxis with hypotension, dyspnea, Hypersensitivity to any component of the
Antivenene Serum (Sea snake) 1000 1000 units by IV infusion over 1/2 to 1 hour. In severe Sensitivity testing should be performed before the urticaris, Immune hypersensitivity reaction , formulation, unless the benefits outweigh the
- Treatment for sea snake bites Not known
units/26.3 ml Injection cases 3000 -10000 units may be required administration shock, transfusion reaction due to serum protein risks and appropriate management for
reaction ,serum sickness anaphylaxis is available
Recommended initial dose is 20ml by intravenous
infusion. The injection should be given very slowly as 5 Anaphylaxis with hypotension, dyspnea, Hypersensitivity to any component of the
Antivenene Serum Snake polyvalent minutes by direct slow intravenous route or 1hour by Sensitivity testing should be performed before the urticaris, Immune hypersensitivity reaction , formulation, unless the benefits outweigh the
Antidote for snake bites Not known
Injection infusion. If symptoms continue, further doses are administration shock, transfusion reaction due to serum protein risks and appropriate management for
administered as required until symptoms completely reaction ,serum sickness anaphylaxis is available
disappear
Alfuzosin, alprazolam, astemizole,
carbamazepine, cisapride, clarithromycin,
dexamethasone, diltiazem, eletriptan, ethinyl
estradiol, etonogestrel, fentanyl ,ifosfamide,
In combination with other antiemetic agents for Moderate to severe liver impairment, pregnancy. Hiccups, asthenia or fatigue, increased
125 mg 1 hour prior to chemotherapy on Day 1. To be imatinib, irinotecan, iraconazole, ketoconazole,
prevention of delayed nausea and vomiting associated Caution is advised both during and up to 2 weeks ALT/AST, constipation, diarrhea, dyspepsia, Hypersensitivity, breastfeeding, concurrent use
Aprepitant 125 mg Capsule Emend given as part of a 3-day regimen that includes a levonorgestrel, medroxyprogesterone,
with initial and repeat course of highly emetogenic after the end of treatment due to the inhibitory and eructation, headache, dizziness, anorexia, of pimozide, terfenadine, astemizole, cisapride
corticosteroid and a 5-HT3 antagonist methylprednisolone, midazolam, norethindrone,
chemotherapy inductive effects of aprepitant on CYP3A4 substrates Stevens-Johnson syndrome and somnolence
norgestrel, paclitaxel, paroxetine, phenytoin,
rifampin, ritonavir, etrfenadine, tolbutamide,
vinblastine ,vincristine, liposome vinorelbine,
warfarin
Alfuzosin, alprazolam, astemizole,
carbamazepine, cisapride, clarithromycin,
dexamethasone, diltiazem, eletriptan, ethinyl
Moderate to severe liver impairment, pregnancy. estradiol, etonogestrel, fentanyl ,ifosfamide,
In combination with other antiemetic agents for Hiccups, asthenia or fatigue, increased
80 mg once daily in the morning on Days 2 and Day 3. Caution is advised both during and up to 2 weeks imatinib, irinotecan, iraconazole, ketoconazole,
prevention of delayed nausea and vomitting associated ALT/AST, constipation, diarrhea, dyspepsia, Hypersensitivity, breastfeeding, concurrent use
Aprepitant 80 mg Capsule Emend To be given as part of a 3-day regimen that includes a after the end of treatment due to the inhibitory and levonorgestrel, medroxyprogesterone,
with initial and repeat course of highly emetogenic eructation, headache, dizziness, anorexia, of pimozide, terfenadine, astemizole, cisapride
corticosteroid & a 5-HT3 antagonist inductive effects of aprepitant on CYP3A4 methylprednisolone, midazolam, norethindrone,
chemotherapy Stevens-Johnson syndrome and somnolence
substrates. norgestrel, paclitaxel, paroxetine, phenytoin,
rifampin, ritonavir, etrfenadine, tolbutamide,
vinblastine ,vincristine, liposome vinorelbine,
warfarin
All patients should receive a 1 ml IV test dose at least
10 minutes prior to loading dose. Initially 2 million KIU MI, shock, kidney tubular necrosis, lung Increased effect with heparin. Blocks aktivity of
Only for Open Heart Surgery (extracorporeal Previous exposure to aprotinin (increased risk of
Aprotinin 10,000 KIU/ml Injection Trasylol bolus followed by 2 million KIU in heart-lung machine oedema,atrial fibrillation, hypersensitivity Hypersensitivity to aprotinin products thrombolytic agents and antihypertensive effects
circulation) hypersensitivity),renal insufficiency.
followed by a slow infusion of 500,000 KIU/hr until end reactions, localised thrombophlebitis of ACE inhibitors, succinylcholine
of surgery. CHILD: 20,000 KIU/kg/day
It should not be used before phototherapy or in
Aqueous Cream - Dry skin As a soap or apply to the skin as an emollient cream Not known Not known Not known
phototesting procedures
Suicide, tardive dyskinesia, neuroleptic malignant
Insomnia, restlessness, headache, dizziness,
syndrome, seizure disorder, diabetes mellitus, CV
akathisia, somnolence, sedation, tremor,
disease, cerebrovascular disease, dementia-related
i) Treatment of acute episodes of schizophrenia and for Schizophrenia: 10 or 15 mg/day. Maintenance dose: 15 extrapyramidal disorder, blurred vision,
psychosis and CV adverse events in elderly. May
maintenance of clinical improvement during mg/day. Bipolar mania: Starting dose: 15 or 30 mg/day. tachycardia, orthostatic hypotension, nausea, Patients who are hypersensitive to aripiprazole Enhance effect of antihypertensive agents,
Aripiprazole 10mg Tablet Abilify, AripMT disrupt body's ability to increase/reduce core body
continuation therapy. ii) Treatment of acute manic Dose adjustment should occur at intervals of not less vomiting, constipation, dyspepsia, or to any of the excipients. alcohol, quinidine, ketoconazole, carbamazepine
temperature. Dysphagia, pregnancy & lactation. May
episodes associated with bipolar I disorder than 24 hour asthenia/fatigue, weight gain, anxiety diabetic
impair ability to drive or operate machinery. Safety
ketoacidosis , neuroleptic malignant syndrome,
and efficacy have not been established in children
seizure, peripheral oedema
less than 13 years of age
Suicide, tardive dyskinesia, neuroleptic malignant
Insomnia, restlessness, headache, dizziness,
syndrome, seizure disorder, diabetes mellitus, CV
akathisia, somnolence, sedation, tremor,
disease, cerebrovascular disease, dementia-related
i) Treatment of acute episodes of schizophrenia and for Schizophrenia: 10 or 15 mg/day. Maintenance dose: 15 extrapyramidal disorder, blurred vision,
psychosis and CV adverse events in elderly. May
maintenance of clinical improvement during mg/day. Bipolar mania: Starting dose: 15 or 30 mg/day. tachycardia, orthostatic hypotension, nausea, Patients who are hypersensitive to aripiprazole Enhance effect of antihypertensive agents,
Aripiprazole 15mg Tablet Abilify, AripMT disrupt body's ability to increase/reduce core body
continuation therapy. ii) Treatment of acute manic Dose adjustment should occur at intervals of not less vomiting, constipation, dyspepsia, or to any of the excipients. alcohol, quinidine, ketoconazole, carbamazepine
temperature. Dysphagia, pregnancy & lactation. May
episodes associated with bipolar I disorder than 24 hour asthenia/fatigue, weight gain, anxiety diabetic
impair ability to drive or operate machinery. Safety
ketoacidosis , neuroleptic malignant syndrome,
and efficacy have not been established in children
seizure, peripheral oedema
less than 13 years of age
Hypersensitivity to lumefantrine or halofantrine,
ADULT and CHILD over 12 years weighing over 35 kg :
or artemether or other artemisinin compounds, Droperidol, amiloride, amitriptyline, azithromycin,
4 tablets as a single dose at the time of initial diagnosis,
history of arrhythmias, bradycardia, and chlorpromazine, ciprofloxacin, clomipramine,
again 4 tablets after 8 hours and then 4 tablets twice Abdominal pain, anorexia, diarrhea, vomiting,
Electrolyte disturbances, hepatic impairment, renal congestive heart failure accompanied by erythromycin, fluconazole, frusemide,
Artemether 20mg + Lumefantrine daily (morning and evening) on each of the following nausea, palpitation, cough, headache, dizziness,
Riamet Acute uncomplicated falciparum malaria impairment, concomitant administration of drugs that reduced left ventricular ejection fraction, hydrochlorothiazide, mefloquine, nalidixic acid,
120mg two days (total course comprises 24 tablets). INFANT sleep disturbances, asthenia, arthralgia, myalgia,
prolong QT interval, first trimester of pregnancy congenital QT interval prolongation. Not ofloxacin, procainamide, pyrimethamine,
and CHILD weighing 5 kg to less than 35 kg : A 6 dose cough, asthenia, fatigue, pruritus, rash
recommended in the first trimester of pregnancy quinidine, quinine, spironolactone, sulfadoxine
regimen with 1 to 3 tablets per dose, depending on
or in children below 5 kg, lactation, family history and pyrimethamine
bodyweight
of sudden death
Use cautiously in patients with preexisting kidney Antacids, aspirin, contraceptives combination,
ADULT: 100-250 mg once or twice daily CHILD: 100
stone disease, erythrocyte G6PD deficiency, In large doses, gastrointestinal disturbances, cyanocobalamin, deferoxamine, gentamicin,
Ascorbic Acid 100 mg Tablet Vitamin C deficiency mg three times daily for one week followed by 100mg History of hyperoxaluria
haemochromatosis, thalassaemia or sideroblastic renal calcium oxalate calculi formation haloperidol, iron, levodopa, methotrexate,
daily until symptoms abate.
anaemia and avoid rapid intravenous injections warfarin
ADULT: 100-250 mg once or twice daily CHILD: 100
stone disease, erythrocyte G6PD deficiency, In large doses, gastrointestinal disturbances, cyanocobalamin, deferoxamine, gentamicin,
Ascorbic Acid 500 mg Tablet Vitamin C deficiency mg three times daily for one week followed by 100mg History of hyperoxaluria
haemochromatosis, thalassaemia or sideroblastic renal calcium oxalate calculi formation haloperidol, iron, levodopa, methotrexate,
daily until symptoms abate.
Therapeutic: Not less than 250 mg daily in divided stone disease, erythrocyte G6PD deficiency, In large doses, gastrointestinal disturbances, cyanocobalamin, deferoxamine, gentamicin,
Ascorbic Acid 500 mg/2 ml Injection For prevention and treatment of scurvy History of hyperoxaluria
doses haemochromatosis, thalassaemia or sideroblastic renal calcium oxalate calculi formation haloperidol, iron, levodopa, methotrexate,
Avoid abrupt withdrawal; gradual withdrawal over a
period of 1 to 2 weeks is recommended. Hypersensitivity to atenolol products,
Hypertension and arrythmias; 50 - 100 mg daily, Bronchospastic disease, congestive heart failure, Chronic heart failure, AV block, bradycardia, bradycardia, 2nd and 3rd degree AV block overt
Hypertension, angina pectoris, myocardial infarction Clonidine, catecholamine-depleting agents, beta-
Atenolol 100 mg Tablet Tenormin Angina; 100 mg daily, Myocardial infarction; diabetes mellitus, hyperthyroidism/thyrotoxicosis. bronchospasm, dizziness, vertigo, nausea, cardiac failure, cardiogenic shock, metabolic
and arrhythmias blockers
individualised Patients receiving clonidine - discontinue atenolol fatigue, diarrhoea acidosis, severe peripheral circulatory
several days prior to withdrawal of clonidine. disturbances, sick sinus syndrome
Peripheral vascular and renal disease
period of 1 to 2 weeks is recommended. Hypersensitivity to atenolol products,
Hypertension and arrythmias; 50 - 100 mg daily, Bronchospastic disease, congestive heart failure, Chronic heart failure, AV block, bradycardia, bradycardia, 2nd and 3rd degree AV block overt
Hypertension, angina pectoris, myocardial infarction Clonidine, catecholamine-depleting agents, beta-
Atenolol 50 mg Tablet Tenormin Angina; 100 mg daily, Myocardial infarction; diabetes mellitus, hyperthyroidism/thyrotoxicosis. bronchospasm, dizziness, vertigo, nausea, cardiac failure, cardiogenic shock, metabolic
and arrhythmias blockers
individualised Patients receiving clonidine - discontinue atenolol fatigue, diarrhoea acidosis, severe peripheral circulatory
several days prior to withdrawal of clonidine. disturbances, sick sinus syndrome
Gastrointestinal disorder or cardiovascular

Hypotension, cardiovascular or cerebrovascular
CHILD and ADOLESCENTS up to 70 kg: Initially 0.5 disorders, weight loss, decreased appetite,
Attention deficit hyperactivity disorder (ADHD) in disease. Hypertension tachycardia. Urinary retention
mg/kg/day for at least 7 days, then increased according weight loss. Nervous system disorders such as
children 6 years and older who do not respond to or bladder dysfunction. Monitor growth in children, MAOIs, CYP2D6 inhibitors (fluoxetine,
to response. Maintenance: 1.2 mg/kg/day. ADULTS dizziness, headache, insomnia, somnolence, Concomitant use with MAOIs. Narrow-angle
Atomoxetine HCl 10 mg Capsule Strattera methylphenidate or who have intolerable effects or QT interval prolongation, history of seizures, paroxetine), salbutamol, pressor agents, drugs
and ADOLESCENTS more than 70 kg: Initially 40 mood swings, urinary retention, dysmenorrhea, glaucoma, liver injury, jaundice
have tics. Diagnosis should be made according to DSM susceptibility to angle-closure glaucoma, hepatic that affect noradrenaline
mg/day for at least 7 days then increased according to ejaculation disorder. Orthostatic hypotension and
IV criteria or the guidelines in ICD-10 impairment, suicidal ideation. Pregnancy and
response. Maintenance: 80 mg/day. Max 100 mg/ day syncope, psychiatric disorders such as irritability,
lactation
suicidal thought

Attention deficit hyperactivity disorder (ADHD) in disease Hypertension tachycardia. Urinary retention
lactation
suicidal thought

lactation
suicidal thought

Attention deficit hyperactivity disorder (ADHD) in disease Hypertension tachycardia. Urinary retention
lactation
suicidal thought

Atomoxetine HCl 60mg Capsule Strattera methylphenidate or who have intolerable effects or QT interval prolongation, history of seizures, paroxetine), salbutamol, pressor agents, drugs
lactation
suicidal thought
Heavy alcohol use, history of liver disease.
Risk of myopathy increased with concurrent
Discontinue therapy if serum transaminase levels
Gastrointestinal disturbances, headache, administration of cyclosporin, fibric acid
rise to 3 times upper limit of normal and are
myalgia, asthenia, insomnia, angioneurotic derivatives, erythromycin, niacin or azole
Hypercholesterolaemia and coronary heart disease persistent. This class of drug has been known to Liver disease, hypersensitivity to atorvastatin,
Atorvastatin 20 mg Tablet Lipitor 10 mg once daily. Maximum: 80 mg daily oedema, muscle cramps, myostitis, myopathy, antifungals. Decreased atorvastatin plasma
intolerant or not responsive to other forms of therapy cause myopathy and renal failure due to pregnancy or lactation
cholestatic jaundice, peripheral neuropathy, concentration with oral antacid suspensions
rhabdomyolysis. Concomitant administration of
pruritus containing magnesium and aluminium
fibrates, niacin, cyclosporin or erythromycin may
hydroxides and colestipol
increase the risk of myopathy
ADULT and CHILD more than 1 month: Initially 300 - Tachycardia, flushing, skin and allergic
Other neuromuscular disease, severe Effect enhanced by inhalation anaesthesia,
Atracurium Besylate 25 mg/2.5 ml 600 mcg/kg IV injection. Subsequent doses of 80 - 200 reactions.Transient hypotension attributed to
Tracrium Muscle relaxation cardiovascular disease, myasthenia gravis & severe Not known aminoglycoside, polymyxins, lithium, magnesium
Injection mcg/kg may be given as necessary. IV infusion: 5 - 10 histamine release. Rarely, bronchospasm,
electrolyte disorders salts, procainamide and quinidine
mcg/kg/minute (300 - 600 mcg/kg/hour) anaphylactoid reactions
ADULT and CHILD more than 1 month: Initially 300 - Tachycardia, flushing, skin and allergic
Other neuromuscular disease, severe Effect enhanced by inhalation anaesthesia,
Atracurium Besylate 50 mg/5 ml 600 mcg/kg IV injection. Subsequent doses of 80 - 200 reactions.Transient hypotension attributed to
Tracrium Muscle relaxation cardiovascular disease, myasthenia gravis & severe Not known aminoglycoside, polymyxins, lithium, magnesium
Injection mcg/kg may be given as necessary. IV infusion: 5 - 10 histamine release. Rarely, bronchospasm,
electrolyte disorders salts, procainamide and quinidine
mcg/kg/minute (300 - 600 mcg/kg/hour) anaphylactoid reactions
Atropine Sulphate 0.3%, Cocaine HCl
Subconjunctival injection to dilate pupils resistant to Prolonged use may produce local irritation, dry Glaucoma or suspected glaucoma.
1.7%, Adrenaline Acid Tartrate 0.03% - 1 - 2 drops Elderly, infant, children Not known
topical mydriatics throat and eczema of eyelids Hypersensitivity
Mydriatic Injection
PREOPERATIVE MYDRIASIS : one drop of a 1%
Determination of refraction, strabismus, iritis and solution supplemented with one drop of 2.5 or 10% Transient stinging and raised intra-ocular
Risk of systemic effects with the eye drops in infants Glaucoma or suspected glaucoma.
Atropine Sulphate 1% Eye Drops - iridocyclitis, after extra or intracapsular extraction of phenylephrine prior to surgery. ANTERIOR UVEITIS or pressure, local irritation, hyperaemia, oedema Not known
under 3 months-eye ointment preferred Hypersensitivity
lens POSTOPERATIVE MYDRIASIS : one drop of a 1% or and conjunctivitis
2% solution up to 3 times a day
paediatric and geriatric patients, debilitated patients
Loss of cisapride efficacy, procainamide
i) ADULT 300-600 mcg IM/SC 30-60 minutes before with lung disease, autonomic neuropathy, hepatic or
coadministered with atropine may result in
anaesthesia or 300-600 mcg IV immediately before renal disease, may cause heat prostration, patients
Constipation, transient bradycardia (followed by Hypersensitivity to atropine or anticholinergics, additive antivagal effects on atrioventricular
i) Reduce vagal inhibition,salivary and bronchiol induction of anaesthesia ii) ADULT 0.5-1 mg repeated, with ileostomy or colostomy, diarrhoea may indicate
tachycardia, palpitations & arrhythmias), reduced narrow-angle glaucoma, reflux oesophagitis, nodal conduction Major interaction with
secretion in anaesthesia ii) Reversal of excessive every 3-5 minutes. Max Dosage: 0.04 mg/kg body incomplete intestinal obstruction, avoid driving or
bronchial secretions, urinary urgency & retention, obstructive gastrointestinal disease/uropathy, potassium, topiramate, effect of atropine and
Atropine Sulphate 1mg/ml Injection - bradycardia iii) Reversal of effect of competitive muscle weight iii) ADULT 0.6-1.2 mg before or with hazardous activities, may cause neuromuscular
dilatation of the pupils with loss of ulcerative colitis or toxic megacolon, unstable other antimuscuranic may be enahnced by
relaxants iv) Overdosage with other compounds having anticholinesterase iv) ADULT 0.5-1 mg IV/SC, repeated blockade resulting in weakness or paralysis,
accommodation, photophobia, dry mouth, cardiovascular status in acute haemorrhage or concomitant administration of drug with
muscarinic action v) Organophosphate poisoning every 2 hour v) ADULT 2 mg IV/IM, every 30 minutes hyperthyroidism, coronary heart disease, acute
flushing & dryness of the skin thyrotoxicosis antimuscuranic properties. MAOIs may enhance
according to clinical response. Cholinesterase myocardial ischemia, CHF, tachyarrhythmia,
atropine effect. Reduce GIT motality may affect
reactivator should be given at the earliest possible time tachycardia, HTN, or prostatic hypertrophy,
other oral drug absorption
pregnancy, neonates
Chronic immunosuppression , increases risk of
Gastrointestinal disturbances,
neoplasm, hematologic toxicity, mutagenicity.
myelosuppression, pancreatitis, fever.
Bleeding or bruising or signs of infection, bone ACEI, Angiotensin II Antagonist, warfarin,
Opportunistic infections especially in transplant
marrow suppression. Monitor FBC weekly during Hypersensitivity, pregnancy, previous alkylating allopurinol, live vaccines, antibacterial. Reduces
patients receiving concomitant other
Azathioprine 50 mg Tablet Imuran i)Acute leukaemia ii)Immunosuppressive agent i) 1-4 mg/kg/day ii) 1.5-2 mg/kg/day first 8 week of therapy especially with high dose or agents such as cyclophosphamide, the neuromuscular blockade of curare,
immunosuppressants. Bone marrow depression,
severe renal/hepatic impairment. Inherited deficiency chlorambucil, melphalan (risk of neoplasms) tubocurarine but potentiates that of
leucopenia, thrombocytopenia, nausea.
of thiopurine methyltransferase enzyme. Avoid succinylcholine
Uncommonly, anaemia, hypersensitivity
excessive sun/UV exposure. Pregnancy, lactation
reactions, cholestasis, pancreatitis
and elderly
Avoid contact with eyes. May cause
Apply twice daily. Treatment should not exceed 6 Occasionally, local skin irritation, pruritus, tingling Hypersensitivity to propylene glycol and azelaic
Azelaic Acid 20% Cream Skinoren Acne vulgaris hypopigmentation. Should not use with occlusive Not known
months feeling, burning or stinging acid products
dressings or wrappings
Nausea, abdominal discomfort, vomiting,
CHILD 36 - 45 kg: 400 mg, 26 - 35 kg: 300mg, 15 - 25 Antacids. Ergot derivatives. Monitor patients on
flatulence, diarrhoea & loose stools. Hearing
Treatment of complicated respiratory tract infections kg 200 mg, less than 15 kg: 10 mg/kg. To be taken Moderate or severe renal impairment; severe liver Known hypersensitivity to azithromycin or any of concurrent warfarin, digoxin or cyclosporin.
Azithromycin 200 mg/5 ml Granules Zithromax impairment, interstitial nephritis, acute renal
not responding to standard macrolides daily for 3 days or to be taken as a single dose on day impairment; pregnancy & lactation the macrolides Increase levels of tacrolimus, phenytoin,
failure, abnormal liver function, dizziness/vertigo,
1, then half the daily dose on days 2 - 5 bromocriptine, disopyramide
convulsions, headache, somnolence
i) Treatment of complicated respiratory tract infection
not responding to standard macrolides ii) Adult
flatulence, diarrhoea & loose stools. Hearing
treatment of uncomplicated genital infections due to i) 500 mg daily for 3 days ii) 1 g as a single dose iii) 1 g Moderate or severe renal impairment, liver Known hypersensitivity to azithromycin or any of Antacids, ergot derivatives. Monitor patients on
Azithromycin 250 mg Tablet Zithromax impairment, interstitial nephritis, acute renal
Chlamydia trichomatis or susceptible Neisseria weekly impairment, pregnancy & lactation the macrolides concurrent warfarin, digoxin or cIclosporin
failure, abnormal liver function, dizziness &
gonorrhoea iii) Prophylaxis against Mycobacterium
vertigo, convulsions, headache, somnolence
avium complex in patients with advanced HIV
Antacids, ergot derivatives. Monitor patients on
500 mg IV as a single daily dose for a minimum of two flatulence, diarrhoea& loose stools. Hearing
Moderate or severe renal impairment, sever liver Known hypersensitivity to azithromycin or any of concurrent warfarin, digoxin or ciclosporin.
Azithromycin 500 mg Injection Zithromax Only for treatment of severe atypical pneumonia days followed by 500 mg oral dose as a single daily impairment, interstitial nephritis, acute renal
impairment, pregnancy & lactation the macrolides Increase levels of tacrolimus, phenytoin,
dose to complete a 7 - 10 days course failure, abnormal liver function, dizziness&
bromocriptine, disopyramide
vertigo, convulsions, headache, somnolence
ADULT: 400 mg twice daily. Severe infection: 800 mg
Infections caused by ampicillin-sensitive gram Hypersensitivity to cephalosporins, renal or hepatic Diarrhoea, indigestion, urticarial or erythematous
Bacampicillin 400 mg Tablet Penglobe twice daily. CHILD more than 25 kg: 12.5 - 25 mg/kg 12 Hypersensitivity to penicillins Aminoglycosides, oral contraceptives
positive& gram negative microorganisms impairment, superinfection rash, hepatitis, cholestatic jaundice
hourly
Pregnancy, patients suffering not only from spasticity Tricyclics and lithium enhance muscle relaxant
Daytime sedation, drowsiness, nausea and other
but also from psychotic disorders, schizophrenia or effect, ACE inhibitor, diuretics and
ADULT: 5 mg 3 times daily. Max: 80 mg daily. CHILD: central nervous system disorders, Epilepsy and other convulsive conditions, corticol
confusional states, epilepsy, cerebrovascular or antihypertensives enhance hypotensive effect.
Baclofen 10 mg Tablet Lioresal Spasticity of the skeletal muscle 0.75 - 2 mg/kg daily (more than 10 years, maximum: gastrointestinal disturbances, dysuria, frequency or subcorticol brain damage, peptic ulceration,
respiratory insufficiency. Central nervous system Sedative effect enhanced with alcohol,
2.5 mg/kg daily) of micturition, enuresis or retention of urine, known hypersensitivity to baclofen
depressants, antihypertensives, levodopa. Caution anxiolytics and hypnotics. Excretion reduced by
respiratory depression
in road users. Avoid abrupt discontinuation ibuprofen and possibly other NSAIDs
For local use only. The use of additives with this Hypersensitivity to any of the components of
Balanced Salt Solution Ocusol For irrigation during ocular surgery Irrigate as directed Ocular irritation Not known
solution may cause corneal decompensation product
Balanced Salt Solution PLUS (fortified For irrigation during intraocular surgery especially in It does not contain a preservative; therefore, do not
Hypersensitivity to any of the components of
with sodium bicarbonate, glucose & B.S.S PLUS patients with poor cornea endothelium and poorly Irrigate as directed reuse for more than one patient. Tissue damage Ocular irritation Not known
product
glutathione) controlled diabetes could result if other drugs are added to the product
Intestinal obstruction, pyloric stenosis or lesions

which may predispose to obstruction, conditions Hypersensitivity reactions, constipation,
which may predispose to perforation such as acute aspiration pneumonia if aspirated, ventricular
Gastrointestinal perforation, acute bleeding from
ulcerative colitis and acute diverticulitis. Adequate fibrillation, bradycardia, asystole,
i) Up to 150 ml of a 50% - 200% suspension orally ii) gastrointestinal tract, peritonitis, pneumatosis
For x-ray examination of the alimentary tract: i) hydration should be ensured after the procedure to electrocardiographic changes, and hypotension,
Barium Sulphate Suspension Baritop, Barytgen Up to 300 ml of a 30% - 200% suspension orally iii) Up intestinalis, gross intestinal obstruction, known or Not known
Oesophagus ii) Stomach and duodenum iii) Colon prevent severe constipation, history of bronchial urticaria, pruritus, erythema and generalized
to 2 litre of a 30% - 200% suspension orally suspected perforation, hypersensitivity to
asthma or allergy, previous reaction to a contrast rashes, dysphagia, constipation, diarrhea, acute
anything in the barium sulfate suspension
agent, hypertension, advanced cardiac disease, pritonitis, anaphylactic reactions, headache,
intussusception with symptoms of more than 24 dyspnea
hours duration, tracheoesophageal fistula
Constipation, UTI pain, nausea, peripheral
oedema, hypertension, anaemia, surgical wound
complication, weight gain, increased serum
ADULT & CHILD 2 years and above & 35 kg or creatinine, hypophosphataemia diarrhoea, upper
more:20 mg /dose. 2 years or more but less than Pregnancy, avoid breast-feeding for 4 months after respiratory tract infection, hypertrichosis, rhinitis, Immunosuppressives other than ciclosporin and
Prophylaxis of acute organ rejection in de novo renal Known hypersensitivity to basiliximab and
Basiliximab 20 mg Injection Simulect 35kg:10 mg/dose. First dose given within 2 hours the last dose. Re-exposure to a subsequent course fever, viral infection, sepsis, atrial fibrillation; corticosteroids may increase the potential for
transplantation. murine proteins
before start of transplantation and second dose 4th day of therapy of basiliximab headache, insomnia, hypokalaemia, over-immunosuppression
after transplant hyperglycaemia, hyperuricaemia,
hypophosphataemia, hypercholesterolaemia,
tremor, dyspnoea, infection. Hypersensitivity and
anaphylactoid-type reactions
Asthmatic patients, Immunogenic material can result
in astmatic attacks or anaphylaxis. The person
preparing the product should wear gloves, mask and
Hypersensitivity to BCG vaccine. Patients with
gown. Discarded containers, syringes and other Flu-like symptoms, chemical cystitis, urinary tract
positive tuberculin tests, AIDS, burns, on Concurrent use with antimicrobial therapy and
equipment used for handling the vaccine should be infection, nausea, vomiting, anorexia, hematuria,
81 mg intravesically once weekly for 6 weeks, followed immunosuppressive therapy or with immunosuppressive agents may impair efficacy
sterilised before disposal. BCG (intravesical) should urinary frequency, dysuria, local irritative
BCG 81 mg/3 ml Immucyst Superficial bladder cancer by treatments at 3, 6, 12, 18, and 24 months after initial compromised immune systems, who had a of BCG, Drug combinations containing bone
not be administered if there is indication that symptoms, diarrhea; anemia, leukopenia,
treatment transurethral resection or traumatic bladder marrow depressants &/or immunosuppressants
catherisation has been traumatic. BCG should not be prostatitis, ureteral obstruction, systemic BCG
catheterization in the previous week. Active TB, &/or radiation may impair the response
administered earlier than 7 days following infection
evidence of systemic BCG reaction, fever, UTI
transurethral resection. Urine voided in the first 6
hours following intravesical BCG instillation should
be handled as infection waste.
Congenital or acquired cell-mediated immune
deficiencies (including HIV), patients with
0.1 ml by intradermal injection. INFANT under 12 Superficial, self healing ulceration, injection site systemic corticosteroid/ immunosuppressive
BCG Vaccine Freeze-Dried Injection - For the prevention of tuberculosis Children born to HIV positive mothers, pregnancy Not known
months: 0.05 ml reaction, lymphadenopathy treatment, malignant condition, pyrexia,
generalised infected dermatoses, organ
abnormalities
Pulmonary tuberculosis, pregnancy. Adrenal Candidiasis of the mouth and throat, hoarseness
Hypersensitivity to beclomethasone
insufficiency (when replacing systemic corticosteroid or throat irritation, headache, secondary
ADULT : 100 mcg 3 - 4 times daily or 200 mcg twice dipropionate, acute asthma exacerbations,
Beclomethasone Dipropionate 100 Prophylaxis of asthma especially if not fully controlled therapy), exposure to viral infection (chickenpox, hypocortisolism, osteoporosis, cataract,
Becotide daily. CHILD more than 6 years : 50 - 100 mcg 2 - 4 status asthmaticus. Special care is necessary in Not known
mcg/dose Inhalation by bronchodilators measles), ocular herpes simplex, tuberculosis glaucoma, paradoxical bronchospasm
times daily patients with active or quiescent pulmonary
(active or quiescent), untreated fungal, bacterial, or (discontinue immediately). Patients are advised
tuberculosis
systemic viral infections to gargle after using the medication
Pulmonary tuberculosis, pregnancy. Adrenal Candidiasis of the mouth and throat, hoarseness
Hypersensitivity to beclomethasone
insufficiency (when replacing systemic corticosteroid or throat irritation, headache, secondary
dipropionate, acute asthma exacerbations,
Beclomethasone Dipropionate 200 Prophylaxis of asthma especially if not fully controlled ADULT : 1 - 2 puff twice daily. May increase to 2 puff 2 - therapy), exposure to viral infection (chickenpox, hypocortisolism, osteoporosis, cataract,
Beclomet status asthmaticus. Special care is necessary in Not known
mcg/dose Inhalation by bronchodilators 4 times daily measles), ocular herpes simplex, tuberculosis glaucoma, paradoxical bronchospasm
patients with active or quiescent pulmonary
(active or quiescent), untreated fungal, bacterial, or (discontinue immediately). Patients are advised
tuberculosis
systemic viral infections to gargle after using the medication
Nasal irritation, sneezing, epistaxis, rhinorrhea,

ADULT and CHILD over 6 years : Apply 100 mcg (2
watery eyes, nasopharyngeal candidiasis, nasal After nasal surgery or if having untreated nasal
sprays) into each nostril twice daily or 50 mcg (1 spray)
Beclomethasone Dipropionate 50 Prophylaxis and treatment of perennial and seasonal Tuberculosis, first trimester of pregnancy, local or septal perforation, dryness and irritation of the infection, acute asthma exacerbations,
Beconase into each nostril 3 - 4 times/day. Maximum 400 mcg Effects enhanced by nasal vasoconstrictors
mcg/dose Nasal Spray allergic rhinitis and vasomotor rhinitis systemic infection, hypercorticism nose and throat, hoarseness, unpleasant taste hypersensitivity to beclomethasone, status
daily (8 sprays). When symptoms controlled, reduce
and smell, glaucoma, rashes, urticaria, pruritis, asthmaticus
dose to 50 mcg (1 spray) into each nostril twice daily
erythema, cataract, glaucoma
Wash and dry baby's bottom. Apply by spreading the
Benzalkonium 0.01% Cream Drapolene Prevention and treatment of nappy rash cream evenly paying particular attention to the fold of Avoid contact with the eyes, mouth and nose Dermatitis Hypersensitivity to benzalkonium products Not known
the skin, after every nappy change
Benzalkonium Chloride Disinfectant Low level disinfectant suitable for general cleaning and Cleaning purposes: Dilute 1 in 10. Disinfection, use Protect surrounding skin, face and eye. Advice to
Viraclean Skin and eye irritation Hypersensitivity to any of its component Do not mix with other chemicals
Solution disinfection of hard surface undiluted wear personal protective equipment (PPE)
Allergic reactions, glossitis, stomatitis, Hypersensitivity to penicillins& cephalosporins.
i) Treatment of mild to moderately severe infections Diabetes. Not for SC, IV or intralumbarly or into body haemolytic anaemia, leucopenia, Severe pneumonia, empyema, sepsis, Bacteriostatic antibiotics, anti-inflammatory,
Benzathine Penicillin 2.4 mega units i) ADULT: 1.2 mega units IM ii) For syphillis: 2.4 mega
Penadur L.A. due to Penicillin G-sensitive organisms ii) Treatment of cavities. Impaired renal function, infants, elderly, thrombocytopenia, agranulocytosis, neuropathy, pericarditis, meningitis, peritonitis or arthritis antirheumatics, antipyretics, probenecids, oral
Injection (1.8 g) units weekly for 1 - 3 weeks
syphillis hypersensitivity to cephalosporins nephropathy, Jarisch-Herxheimer reactions requiring high dose of penicillin levels, bronchial contraceptives
secondary to bacteriolysis asthma
Autonomic neuropathy, heart disease, hepatic or
renal disease, hyperthyroidism, paediatric, elderly, Children under 3 years, narrow-angle glaucoma,
Severe mental disturbances, confusion,
potential for abuse, prostatic hypertrophy, glaucoma, closed-angle glaucoma, tardive dyskinesias,
ADULT: Initially 1 mg daily. Maintenance: 5 - 15 mg drowsiness, restlessness, hallucinations, Alcohol and central nervous system depressants
i) Parkinson's disease ii) Drug induced parkinsonism iii) obstructive disease of gastrointestinal or prostatic enlargement, paralytic ileus, chronic
Benzhexol 2 mg Tablet Artane daily in 3 - 4 divided doses. CHILD: 0.02 mg/kg/dose 8 excitement, nausea and vomiting, dry mouth, may increase the sedative effect of benzhexol.
Dystonias genitourinary, pregnancy and lactation. Use with pulmonary disease, sick sinus syndrome,
hourly, gradually increasing to 0.1 - 0.3 mg/kg/dose blurring of vision, constipation, urinary retention, Delayed absorption of other oral drugs
caution in patients with ileostomy or colostomy. thyrotoxicosis, cardiac failure with tachycardia,
glaucoma
Avoid driving or hazardous activities. Monitor lactation
intraocular pressure
Benzoic Acid Compound Half Contact with the eyes, mouth and other mucous Hypersensitivity to any component. Diabetes,
Whitfields Tinea infections of the skin Apply sparingly to affected area once or twice daily Local irritation Not known
Strength (Paed) Ointment membranes should be avoided impaired circulation
Contact with the eyes, mouth and other mucous Hypersensitivity, use in children less than 2
Benzoic Acid Compound Ointment Whitfields Tinea infections of thickened skin of palms and soles Apply sparingly to affected area once or twice daily Local irritation Not known
membranes should be avoided years, diabetes impaired circulation
Apply undiluted to the skin 1 or 2 times daily. Duration
Infected skin, lesions, cuts, abrasions, wounds and
Benzoin Compound Tincture of therapy, may be weeks to months depending on the May result in mild irritation at the site of application Allergic reaction and dermatologic effects Hypersensitivity to any of its compound Not known
burns
infection being treated
Avoid contact with eyes, mouth and other mucous
Benzoyl Peroxide 10% Gel Panoxyl Mild to moderate acne vulgaris Apply sparingly once or twice daily membranes. May bleach dyed clothing and fabrics. Burning or stinging contact dermatitis, redness Hypersensitivity to benzoyl peroxide products Not known
Avoid unnecessary sun exposure
Avoid contact with eyes, mouth and other mucous
Benzoyl Peroxide 5% Gel Panoxyl Mild to moderate acne vulgaris Apply sparingly once or twice daily membranes. May bleach dyed clothing and fabrics. Burning or stinging contact dermatitis, redness Hypersensitivity to benzoyl peroxide products Not known
Avoid unnecessary sun exposure
Prostatic hypertrophy, mental disorder, pregnancy,
ADULT: 0.5 - 1 mg daily usually at bedtimes. Dry mouth, blurred vision, nausea and vomiting,
elderly, tachycardia, obstructive uropathy, Narrow angle glaucoma, tardive dyskinesia,
i) Parkinson's disease ii) Drug induced parkinsonism iii) Maintenance: 1 - 4 mg daily in single or divided doses. constipation, allergic reaction, confusion, drug- Phenothiazine, tricyclic antidepresant and
Benztropine Mesilate 2 mg Tablet Cogentin predisposition to glaucoma, untreated narrow angle children below 3 years old, hypersensitivity to
Dystonias Maximum 6 mg daily. CHILD: 0.02 - 0.06 mg/kg/dose 1 - induced psychosis, heat stroke, hyperpyrexia, anticholinergic
glaucoma, tardive dyskinesia. Avoid driving or benztropine or any component
2 times a day paralytic ileus, raised intraocular pressure
hazardous activities
Used as a 30 seconds gargle or rinse, undiluted. Hepatic or renal impairment, pregnancy, children
ADULT 15 ml. CHILD less 12 years 5-15 ml. less than 6 years, in bacterial infection, appropriate Oral numbness, dryness or thirst, tingling, warm Known hypersensitivity to the drug or to any of
Benzydamine HCl 0.15% Solution Difflam For relief of painful condition of the oral cavity Not known
Uninterrupted treatment should not be more than 7 antibacterial therapy should be used in addition to feeling in mouth, altered sense of taste the components of the vehicle
days product
May be irritant to the skin of some patients,
After bath, apply over the whole body, neck down and burning sensation especially on genitalia and
Contact with mucous membranes, head, face,
leave on for 24 hours then wash off. Reapply for excoriations occasionally rashes, stinging and
Benzyl Benzoate 12.5 % Emulsion broken or inflammed skin, avoid contact with eyes.
- Scabies and pediculosis, for child under 2 years another 24 hours, the first repeat application should be contact dermatitis, local irritation, particularly in Hypersensitivity to benzyl benzoate Not known
(Child) Not recommended for children, lactation (withhold
within 5 days of the initial application, a third application children, splash contact with benzyl benzoate
during treatment)
may be required in some cases may produce irritation to the eyes and mucous
membranes
May be irritant to the skin of some patients,
After bath, apply over the whole body, neck down and burning sensation especially on genitalia and
Contact with mucous membranes, head, face,
leave on for 24 hours then wash off. Reapply for excoriations occasionally rashes, stinging and
Benzyl Benzoate 25 % Emulsion broken or inflammed skin, avoid contact with eyes.
- Scabies and pediculosis another 24 hours, the first repeat application should be contact dermatitis, local irritation, particularly in Hypersensitivity to benzyl benzoate Not known
(Adult) Not recommended for children, lactation (withhold
within 5 days of the initial application, a third application children, splash contact with benzyl benzoate
during treatment)
may be required in some cases may produce irritation to the eyes and mucous
membranes
Hypersensitivity reactions, GI disturbances,
i) ADULT: 600 - 1200 mg IM 4 times daily, increased if
eosinophilia, haemolytic anaemia, leucopenia,
necessary in more serious infections. CHILD: 50 - 100 History of anaphylaxis, accelerated (e.g. hives) or History of anaphylaxis, accelerated (e.g. hives) Bacteriostatic antibiotics, anti-inflammatory,
Benzylpenicillin 1 mega unit (600 mg) i) Infections caused by susceptible organisms ii) agranulocytosis. Convulsions in the presence of
- mg/kg body weight daily IV in 2 - 4 divided doses ii) serum sickness reaction to previous penicillin or serum sickness reaction to previous penicillin antirheumatics, antipyretics, probenecids, oral
Injection Infective endocarditis severely reduced renal function, epilepsy,
ADULT: 7.2 g daily by slow IV infusion in 6 divided administration administration contraceptives
meningitis or cerebral oedema or during
doses
cardiopulmonary bypass procedure
Patients with a history of penicillin or cephalosporin
History of anaphylaxis, accelerated (e.g. hives)
Benzylpenicillin 10,000 units/ml Eye 1-2 drops every 15 minutes or accordingly to needs of hypersensitivity reactions, atopic predisposition (e.g.
- Eye infection Skin rashes, anaphylaxis, urticaria or serum sickness reaction to previous penicillin Not known
Drops the patient asthma), impaired renal function, or pre-existing
administration
seizure disorder
Patients with a history of penicillin or cephalosporin
History of anaphylaxis, accelerated (e.g. hives)
Benzylpenicillin 2,500 units/ml (1.5 1-2 drops every 15 minutes or accordingly to needs of hypersensitivity reactions, atopic predisposition (e.g.
- Eye infection Skin rashes, anaphylaxis, urticaria or serum sickness reaction to previous penicillin Not known
mg/ml) Eye Drops the patient asthma), impaired renal function, or pre-existing
administration
seizure disorder
Hypersensitivity reactions, GI disturbances,
i) ADULT: 600 - 1200 mg IM 4 times daily, increased if
eosinophilia, haemolytic anaemia, leucopenia,
necessary in more serious infections. CHILD: 50 - 100 History of anaphylaxis, accelerated (e.g. hives) or History of anaphylaxis, accelerated (e.g. hives) Bacteriostatic antibiotics, anti-inflammatory,
Benzylpenicillin 5 mega units (3 g) i) Infections caused by susceptible organisms ii) agranulocytosis. Convulsions in the presence of
- mg/kg body weight daily IV in 2 - 4 divided doses ii) serum sickness reaction to previous penicillin or serum sickness reaction to previous penicillin antirheumatics, antipyretics, probenecids, oral
Injection Infective endocarditis severely reduced renal function, epilepsy,
ADULT: 7.2 g daily by slow IV infusion in 6 divided administration administration contraceptives
meningitis or cerebral oedema or during
doses
cardiopulmonary bypass procedure
Treatment of newborn baby with birth weight of 700 g
Continuous monitoring with arterial or
Beractant Intratracheal Suspension or greater undergoing mechanical ventilation for 100 mg/kg (4 ml/kg) body weight via endotracheal tube Transient bradycardia, hypoxia, endotracheal
Survanta transcutaneous measurement of systemic oxygen Not known Not known
(200 mg phospholipids in 8 ml vial) respiratory distress syndrome, whose heart rate and every 6 hours (1 - 4 doses) tube reflux
and carbon dioxide
arterial oxygenation are continuously monitored
Betahistine should not be given to patients with
phaeochromocytoma. It should be given with care to
Given in doses of 8 to 16 mg orally 3 times daily (total
Betahistine Dihydrochloride 16 mg Vertigo, tinnitus and hearing loss associated with patients with asthma, peptic ulcer disease or a
24 to 48 mg/day) preferably with food. CHILD not Nausea, vomiting, skin rash, pruritus Hypersensitivity, phaeochromocytoma Selegiline
Tablet Meniere's disease history of peptic ulcer disease. Antihistamines may
recommended
block some or all of intended effects of betahistine.
Liver disease, pregnancy, lactation
Betaserc® 24 mg twice daily Nausea, vomiting, skin rash, pruritus Hypersensitivity, phaeochromocytoma Selegiline
Given in doses of 8 to 16 mg orally 3 times daily (total
24 to 48 mg/day) preferably with food. CHILD not Nausea, vomiting, skin rash, pruritus Hypersensitivity, phaeochromocytoma Selegiline
recommended
CYP3A3/4 enzyme substrate, phenytoin,
Suppression of inflammatory and allergic disorders, 0.5 - 9 mg daily in divided doses. CHILD: 0.5 - 7.5 Discontinue treatment by reducing the dosage Fluid and electrolyte disturbances, muscle Systemic fungal infection (unless specific phenobarbital, potassium-depleting diuretics.
Betamethasone 0.5 mg Tablet Celestone
congenital adrenal hyperplasia, cerebral oedema mg/m2/day divided every 6 - 12 hours gradually weakness, peptic ulcer, Cushing's syndrome antimicrobial therapy given) Skin test antigens, immunizations:
Betamethasone may decrease response
Local skin atrophy, striae, systemic
Viral diseases, bacteria and fungal infection,
Betamethasone 17-Valerate 0.01- Eczemas, prurigo nodularis, limited psoriasis in Apply sparingly to affected area 2 - 3 times daily then Extensive or prolonged use, pregnancy, infant and hypercorticism, folliculitis, hypertrichosis,
Betnovate acne, rosacea and perioral dermatitis. Not known
0.05% Cream appropriate in sites reduced to once daily when improvement occurs children less than 4 years. Avoid contact with eyes acneiform eruptions, hypopigmentation and
Hypersensitivity to betamethasone products
allergic contact dermatitis
Extensive or prolonged use, pregnancy, infant and Viral diseases, bacteria and fungal infection,
Betamethasone 17-Valerate 0.01- Eczema, prurigo nodularis, limited psoriasis in Apply sparingly to affected area 2 - 3 times daily then hypercorticism, folliculitis, hypertrichosis,
Betnovate children less than 4 year. Avoid contact with eyes. acne, rosacea and perioral dermatitis. Not known
0.05% Ointment appropriate in sites reduced to once daily when improvement occurs acneiform eruptions, hypopigmentation, prioral
Use in patients 12 years of age younger Hypersensitivity to betamethasone products
and allergic contact dermatitis
Betamethasone 17-Valerate 0.1% Eczemas, prurigo nodularis, psoriasis (excluding Apply sparingly to affected area 2 - 3 times daily then hypercorticism, folliculitis, hypertrichosis,
Betnovate children less than 4 year. Avoid contact with eyes. acne, rosacea and perioral dermatitis. Not known
Cream widespread plaque psoriasis) reduced to once daily when improvement occurs acneiform eruptions, hypopigmentation and
Use in patients 12 years of age younger Hypersensitivity to betamethasone products
allergic contact dermatitis
Betamethasone 17-Valerate 0.1% Eczema, prurigo nodularis, psoriasis (excluding Apply sparingly to affected area 2-3 times daily then hypercorticism, folliculitis, hypertrichosis,
Betnovate children less than 4 years old. Avoid contact with acne, rosacea and perioral dermatitis. Not known
Ointment widespread plaque psoriasis) reduced to once daily when improvement occurs acneiform eruptions, hypopigmentation, prioral
eyes. Use in patients 12 years of age younger Hypersensitivity to betamethasone products
and allergic contact dermatitis
Viral, fungal, tuberculosis, purulent eye infection,
Betamethasone Disodium Phoshate Apply 2 - 3 drops every 2 - 3 hours, reduce frequency Prolonged use in infants, pregnancy, may result in
Betnesol Non-infected inflammatory conditions Local sensitivity reactions glaucoma, herpetic keratitis, otitis media, history As general with other corticosteroids
0.1% Ear Drops when relief obtained secondary fungal infections
of perforation of the ear drum
Viral, fungal, tuberculosis, purulent eye infection,
Betamethasone Disodium Phoshate Apply 2 - 3 drops every 2 - 3 hours, reduce frequency Prolonged use in infants, pregnancy, may result in
Betnesol Non-infected inflammatory conditions Local sensitivity reactions glaucoma, herpetic keratitis, otitis media, history As general with other corticosteroids
0.5% Ear Drops when relief obtained secondary fungal infections
of perforation of the ear drum
Red eye, steroid glaucoma, steroid cataract,
Bacterial, fungal, viral, tuberculous or purulent
Prolonged use in infants. May impair ability to drive thinning of the cornea and sclera, burning, dry
Betamethasone Disodium Phosphate 1 - 2 drops every 1 - 2 hours until controlled then conditions of the eye. Glaucoma, herpetic
Betnesol Non-infected inflammatory conditions of the eyes or operate machinery. Pregnancy. Withdrawal if eyes, photophobia, glaucoma, elevated Not known
0.1% Eye Drops reduce frequency keratitis (e.g. dendritic ulcer). Hypersensitivity to
there is spread of infection intraocular pressure, optic nerve damage,
any component of the preparation
cataract
Prolonged use in infants. May impair ability to drive thinning of the cornea and sclera, burning, dry
Betamethasone Disodium Phosphate conditions of the eye. Glaucoma, herpetic
Celestone Non-infected inflammatory conditions of the eyes 2 - 4 times daily or at night when used with eye drops or operate machinery. Pregnancy. Withdrawal if eyes, photophobia, glaucoma, elevated Not known
0.1% Eye Ointment keratitis (e.g. dendritic ulcer). Hypersensitivity to
there is spread of infection intraocular pressure, optic nerve damage,
cataract
Viral, fungal infection, tuberculous, purulent eye
Betamethasone Disodium Phosphate Prolonged use in infants, may impair ability to drive
Apply 2 - 3 drops 3 - 4 times daily, reduce frequency Rise in intraocular pressure, epistaxis, ulceration infection, glaucoma, otitis media, history of
and Neomycin Sulphate 0.5% Ear Betnesol-N Allergic dermatosis in the ear and operate machinery, pregnancy, withdraw if there As general with other corticosteroids
when relief obtained of throat perforation of the ear drum, allergy to neomycin
Drops is spread of infection
or to any component of the preparation
Prolonged use in infants. May impair ability to drive Rise in intraocular pressure, corneal ulcers.
Betamethasone Disodium Phosphate conditions of the eye. Glaucoma, herpetic
Betnesol-N Infected inflammatory conditions of the eyes 2 - 3 drops every 2 - 3 hours or operate machinery. Pregnancy. Withdrawal if Rarely, acute sensitization to neomycin, optic Not known
and Neomycin Sulphate Eye Drops keratitis (e.g. dendritic ulcer). Hypersensitivity to
there is spread of infection nerve damage, visual acuity and field defects
Usual intravenous doses are up to 9 mg/day of the
Pre-operative and in serious trauma or illness, shock,
sodium phosphate salt only. CHILD: IM: 0.5 - 7.7 mg
Betamethasone Sodium Phosphate 4 as adjunctive therapy in rheumatoid disorders, ocular, Discontinue treatment by reducing the dosage Fluid and electrolyte disturbances, muscle
Celestone base/m2/day divided every 6 - 12 hours. Systemic fungal infection Not known
mg/ml Injection dermatologic and respiratory allergic and inflammatory gradually weakness, peptic ulcer
ADOLESCENT and ADULT, IM: 0.6 - 9 mg divided
states
every 12 - 24 hours
Diabetes, thyrotoxicosis, patients with excessive Ocular stinging, pain, itching, erythema, dry eyes Epinephrine, catecholamine-depleting drugs,
Patients with bradycardia, heart block, or
Betaxolol 0.25% Eye Suspension Betoptic Chronic open-angle glaucoma, ocular hypertension One to two drops in the affected eye(s) twice daily restriction of pulmonary function, severe reactive and allergic blepharoconjunctivitis, corneal adrenergic psychotropic drugs, oral beta-
uncontrolled heart failure
airway disease, asthma, pregnancy disorders blockers
Enhanced coumarin anticoagulants effect,
Advanced prostate cancer in combination with LHRH 50 mg once daily. (morning or evening), with or without
Bicalutamide 50 mg Tablet Casodex Moderate to severe hepatic impairment GI disturbances, hot flushes, pain Women, children, pregnancy, lactation cimetidine, ketoconazole, cyclosporin and Ca-
analogue therapy or surgical castration. food. Take on the same time each day.
channel blockers
Eyelash formation, conjunctival hyperemia, iris
Aphakia, pseudoaphakia, active intraocular pigmentation, ocular pruritus, conjunctival
Bimatoprost 0.03% Ophthalmic Lowering of intraocular pressure in patients with open- Hypersensitivity to bimatoprost or any
Lumigan 1 drop in affected eye(s) once daily at evening inflammation, macular oedema, renal impairment, oedema, headache, hypertension, common cold, Latanoprost
Solution angle glaucoma and ocular hyperten component of the product
liver impairment, pregnancy, lactation acute upper respiratory infection, superficial
punctuate keratitis
i) ADULT and CHILD over 10 years: 10 mg, CHILD less
Prolonged use, abdominal pain, inflammatory bowel
i) Constipation ii) Bowel preparation for radiological than 10 years 5 mg insert rectally ii) ADULT 10-20 mg, Rarely,electrolyte and fluid imblances, abdominal Ileus, intestinal obstruction, acute abdominal
Bisacodyl 10 mg Suppository Dulcolax disease, sudden, persistent change in bowel habits Milk, antacids, warfarin
procedures and surgery CHILD over 4 years 5 mg the following morning before discomfort, diarrhoea, rectal burning, vomiting conditions, rectal bleeding, appendicitis
and ulcerated haemorrhoids of rectal fissures
procedures insert rectally
i) ADULT and CHILD over 10 years: 10 mg, CHILD less
Prolonged use, abdominal pain, inflammatory bowel
i) Constipation ii) Bowel preparation for radiological than 10 years 5 mg insert rectally ii) ADULT 10-20 mg, Rarely,electrolyte and fluid imblances, abdominal Ileus, intestinal obstruction, acute abdominal
Bisacodyl 5 mg Suppository Dulcolax disease, sudden, persistent change in bowel habits Milk, antacids, warfarin
procedures and surgery CHILD over 4 years 5 mg the following morning before discomfort, diarrhoea, rectal burning, vomiting conditions, rectal bleeding, appendicitis
and ulcerated haemorrhoids of rectal fissures
procedures insert rectally
i) ADULT and CHILD over 10 years 5-10 mg, CHILD 4-
10 years 5 mg. To be taken at night for effect on the
i) Constipation ii) Bowel preparation for radiological Prolonged use, abdominal pain, inflammatory bowel Rarely,electrolyte and fluid imblances, abdominal Ileus, intestinal obstruction, acute abdominal
Bisacodyl 5 mg Tablet Dulcolax following morning ii) ADULT 10-20 mg the night before Milk, antacids, warfarin
procedures and surgery disease, sudden, persistent change in bowel habits discomfort, diarrhoea, rectal burning, vomiting conditions, rectal bleeding, appendicitis
procedures, CHILD over 4 years 5 mg the night before
procedures
Bismuth Subgallate and Benzyl For relief of pruritus, burning and soreness in patients Insert 1 suppository night and morning after bowel Not for prolonged use. Use in children is not
Anusol Local irritation Hypersensitivity to any component of preparation Not known
Benzoate Suppository with haemorrhoids and perianal conditions movements; do not use for longer than 7 days recommended
As a mild antiseptic for wounds and abscesses. Sterile Erythematous rash, encephalopathy reported
Bismuth Subnitrate, Iodoform and Hyperthyroidism, nasal packing use not more than 3 Allergy to iodine or other components in the
BIPP gauze impregnated with paste for packing cavities after As directed for local application only with large packs or when placed directly on Not known
Liquid Paraffin Paste days. Ear packing use not more than 2 weeks preparations
otorhinological surgery neural tissue, nasal mucosal fibrosis
Hypersensitivity, cardiac failure, pulmonary
period of 1 to 2 weeks is recommended. Arrythmia, bradycardia, chest pain, oedema, Prazosin, digoxin, amiodarone, ACEI,
Treatment of stable moderate to severe congestive oedema, pregnancy, severe asthma or severe
Bisoprolol Fumarate 2.5 mg Tablet Concor 1.25 mg once daily to 5 - 10 mg daily Bronchospastic disease, congestive heart failure, hypotension, dizziness, headache, fatique, antidiabetic agent, calcitriol, cholestyramine,
cardiac failure in addition to ACEI's and diuretics chronic obstructive pulmonary disease,
diabetes mellitus, hyperthyroidism/thyrotoxicosis. diarrhoea, nausea, impotency, cough, rhinitis clonidine
hypotension
Hypersensitivity, cardiac failure, pulmonary
period of 1 to 2 weeks is recommended. Arrythmia, bradycardia, chest pain, oedema, Prazosin, digoxin, amiodarone, ACEI,
Treatment of stable moderate to severe congestive oedema, pregnancy, severe asthma or severe
Bisoprolol Fumarate 5 mg Tablet Concor 1.25 mg once daily to 5 - 10 mg daily Bronchospastic disease, congestive heart failure, hypotension, dizziness, headache, fatique, antidiabetic agent, calcitriol, cholestyramine,
cardiac failure in addition to ACEI's and diuretics chronic obstructive pulmonary disease,
diabetes mellitus, hyperthyroidism/thyrotoxicosis. diarrhoea, nausea, impotency, cough, rhinitis clonidine
hypotension
Beware of increased risk of pulmonary fibrosis in
elderly patients (more than 70 years), if radiotherapy
has been given to the chest, if cumulative lifetime
15 - 60 mg weekly in divided doses or 10 - 20 mg/m2 doses of bleomycin are exceeded or if high Erythema, hyperpigmentation of skin, nail
Squamous cell carcinoma, germ cell tumours,
once or twice weekly or 10 mg/m2 slow bolus in 15 concentrations of oxygen is given after bleomycin changes, mucositis, chills, fever, pneumonitis, Hypersensitivity to bleomycin, severe pulmonary Phenothiazines, cisplatinum, radiotherapy,
Bleomycin HCl 15 mg Injection Bleocin lymphomas. Routes: SC, IM, IV (either as bolus or as
minutes D1 and D15. Max: 400 mg. CHILD: 10 - 15 therapy. Monitor lung function. Risk of anaphylatic pulmonary fibrosis, Raynaud's phenomenon, disease, pregnancy, lactation zidovudine
infusion over 24 hours), intra-arterial, intra-pleural
mg/m2 over 6 hours every 3 - 4 weeks reaction is higher in patients with lymphoma hyperpyrexia, hyperkeratosis, striae, stomatitis
receiving bleomycin. Reconstitute in 0.9% sodium
chloride or sterile water. Should not reconstitute in
dextrose-containing solutions
Cumulative effect, if ingested can cause
Boric Acid with Spirit 2% w/v Ear gastrointestinal iritation, loss of appetite. Not Poisoning if absorbed too much, headache,
- Perforated eardrum 3 drops instilled into affected ear 3 - 4 times daily Not known Not known
Drops recommended for children below 3 years except with dermatitis
paediatrician consultation
Asthenic conditions, pyrexia, gastrointestinal
Concomitant use of antihypertensive medications, disturbances, anorexia, dehydration, peripheral
1.3 mg/ m2/dose given as IV bolus injection twice
dehydration, heart disease, hepatic impairment, neuropathy, thrombocytopenia, neutropenia,
weekly for two weeks (days 1, 4, 8, and 11) followed by
Treatment of multiple myeloma in patient who have renal impairment, high tumor burden prior to anaemia, hypotension, cardiac disorders, bone Hypersensitivity to bortezomib, boron or Cytochrome P450 3A4 inducer or inhibitors, oral
Bortezomib 3.5 mg Injection Velcade a 10- day rest period (days 12-21). At least 3 days
received at least one prior therapy treatment, myelosuppression, peripheral neuropathy and body pain, cough, dyspnoea, rash, oedema, mannitol. Child, pregnancy and lactation antidiabetic agents
should elapse between consecutive doses of
or other neurologic disorders, pulmonary disease, hypersensitivity reactions, painful or difficult
bortezomib
acute diffuse infiltrative, history of syncope urination, pneumonia, pyrexia, diarrhoea,
vomiting, dehydration and nausea
Severe cardiovascular disease, liver impairment, Oral dryness, ocular hyperemia, burning and
Alcohol, sedative, barbiturates, opiates,
Brimonidine Tartrate 0.15% Lowering of intraocular pressure in patients with open- renal impairment, depression, Raynauld?s stinging, headache, blurring, foreign body Hypersensitivity to brimonidine, concomitant
Alphagan P 1 drop in the affected eye(s) 3 times daily anaesthesia, tricyclic antidepressant, beta
Ophthalmic angle glaucoma or ocular hypertension phenomenon, orthostatic hypotension, sensation, fatigue, drowsiness, conjunctival MAOI therapy
blocker, antihypertensive
thromboangiitis obliterans, pregnancy, lactation follicles, ocular pruritus
May produce physical and psychological
Theophylline, decreased benzodiazepine
dependence, amnesia, may increase frequency and
effectiveness. Cimetidine may produce
3 - 18 mg daily in divided doses. 6 to 30 mg daily severity of grand mal seizure. Care in organic brain
Fatigue, muscle weakness, drowsiness, Shock, severe psychosis, pregnancy and bromazepam toxicity (CNS depression).
Bromazepam 3 mg Tablet Lexotan Anxiety disorders (single or divided doses) in anxiety-neurosis. Children disease, cardiorespiratory insufficiency, decreased
hypotension, nausea and vomiting breastfeeding Sedative effects increased by other centrally
not recommended hepatic or renal function. COPD or respiratory
acting drugs. Enhances CNS depressants effect
failure. Reduce dose in elderly and avoid chronic
of alcohol
use
Occasionally gastrointestinal effects, skin rashes
Secretolytic therapy in acute and chronic
very rarely. Gastrointestinal disturbances, May lead to higher antibiotic concentration in
Bromhexine HCl 4 mg/2 ml Injection Bisolvon bronchopulmonary diseases associated with abnormal 4 mg SC, IM or IV 2 - 3 times daily Gastrointestinal ulceration, pregnancy and lactation Hypersensitivity to bromhexine
headache, dizziness, sweating, skin rash, lung tissue. Oral anticoagulants
mucous secretion and impaired mucous transport
transient rise in serum transaminase
Nausea, anorexia, abdominal discomfort and
ADULT and CHILD more than 12 years : 10 ml 3 times
Secretolytic therapy in acute and chronic pain, headache, allergic reactions.
daily, 6 - 12 years : 5 ml 3 times daily, 2 - 6 years : 2.5 May lead to higher antibiotic concentration in
Bromhexine HCl 4 mg/5 ml Elixir Bisolvon bronchopulmonary diseases associated with abnormal Gastrointestinal ulceration, pregnancy and lactation Gastrointestinal disturbance, headache, Hypersensitivity to bromhexine
ml 3 times daily, less than 2 years : 1.25 ml 3 times lung tissue. Oral anticoagulants
mucous secretion and impaired mucous transport dizziness, sweating, skin rash, transient rise in
daily
serum transaminase
Secretolytic therapy in acute and chronic ADULT and CHILD more than 12 years : 8 mg 3 times
Gastrointestinal ulceration, pregnancy and May lead to higher antibiotic concentration in
Bromhexine HCl 8 mg Tablet Bisolvon bronchopulmonary diseases associated with abnormal daily, 6 - 12 years : 4 mg 3 times daily, 2 - 6 years : 4 Gastrointestinal ulceration, pregnancy and lactation Hypersensitivity to bomhexine
lactation lung tissue. Oral anticoagulants
mucous secretion and impaired mucous transport mg 2 times daily
Clarithromycin - elevations in serum levels of
Nursing mothers, children under 15 years old, peptic
Hypotension, peripheral vasoconstriction, bromocriptine. Inhibit ciclosporin metabolism.
ulcer disease, postpartum, puerperal women with
i) Initially 1 - 1.25 mg at bedtime increased gradually, dyskinesias, fatigue, nausea, vomiting, Erythromycin - significantly increase the
high blood pressure, coronary artery disease,
usual dose: 7.5 mg daily in divided doses. Max 30 mg constipation, drowsiness, confusion, Hypersensitivity to bromocriptine products, bioavailability of bromocriptine. Bromocriptine,
psychic disorders, concomitant use of other ergot
Bromocriptine Mesilate 10 mg Tablet Parlodel i) Hypogonadism or Galactorrhoea ii) Acromegaly daily ii) 1.25 - 2.5 mg at bedtime for 3 days and may be psychomotor excitation, hallucinations, toxaemia of pregnancy, hypertension in may decrease the metabolism of sirolimus,
alkaloid. Fertility may be restored (contraception
increased by 1.25 - 2.5 mg every 3 - 7 days up to 30 dyskinesias, dryness of the mouth, leg cramps, postpartum and during puerperium tacrolimus . Alcohol reduces tolerance to
needed), malignancy excluded before use for benign
mg a day in divided doses allergic skin reactions. On prolonged treatment, bromocriptine and vice-versa. Effects of
breast disease, acromegalic patients with history of
reversible pallor of fingers and toes antihypertensives may be potentiated. Avoid
peptic ulceration
concurrent psychotropics
Bromocriptine Mesilate 2.5 mg Tablet Parlodel i) Hypogonadism or Galactorrhoea ii) Acromegaly daily ii) 1.25 - 2.5 mg at bedtime for 3 days and may be psychomotor excitation, hallucinations, toxaemia of pregnancy, hypertension in may decrease the metabolism of sirolimus,
peptic ulceration
Bromocriptine Mesilate 5 mg Tablet Parlodel i) Hypogonadism or Galactorrhoea ii) Acromegaly daily ii) 1.25 - 2.5 mg at bedtime for 3 days and may be psychomotor excitation, hallucinations, toxaemia of pregnancy, hypertension in may decrease the metabolism of sirolimus,
peptic ulceration
Mild irritation of the throat, coughing, and
Acute exacerbations, accompanied by increased Oral or parenteral corticosteroids - effects
generally reversible hoarseness of the voice.
Maintenance treatment of asthma as prophylactic ADULT : Initially 1 - 2 mg twice daily. CHILD 3 months - mucous viscosity and mucous plugging. Caution in enhanced by the concomitant use. Amiodarone -
Budesonide 1 mg/2 ml Nebulising Bad taste, dryness of the throat. Candidiasis of Hypersensitivity to budesonide. Moderate to
Pulmicort therapy especially if not fully controlled by 12 years of age : 500 mcg - 1 mg. Maintenance dose : viral infections such as varicella, in untreated fungal increased risk of developing Cushing's
Solution the mouth and throat, paradoxical severe bronchiectasis
bronchodilators half of the above doses and bacterial infections of the respiratory system. syndrome. Ketoconazole, erytromycin, ritonavir -
bronchoconstriction, headache, nausea,
Pregnancy and lactation increased budesonide plasma concentrations
tiredness, thirst, diarrhoea, skin reaction
ADULT : 200 - 1600 mcg daily in 2 - 4 divided doses. generally reversible hoarseness of the voice.
Maintenance treatment of asthma as prophylactic mucous viscosity and mucous plugging. Caution in enhanced by the concomitant use. Amiodarone -
Maintenance with twice daily dosing. CHILD more than Bad taste, dryness of the throat. Candidiasis of Hypersensitivity to budesonide. Moderate to
Budesonide 100 mcg/dose Inhalation Pulmicort therapy especially if not fully controlled by viral infections such as varicella, in untreated fungal increased risk of developing Cushing's
7 years 200 - 800 mcg, 2 - 7 years 200 - 400 mcg. To the mouth and throat, paradoxical severe bronchiectasis
bronchodilators and bacterial infections of the respiratory system. syndrome. Ketoconazole, erytromycin, ritonavir -
be taken orally in 2 - 4 divided doses bronchoconstriction, headache, nausea,
Not for acute attack. Taper dose when discontinuing
ADULT : 1 - 2 puff twice daily, maximum : 4 puff twice treatment. Thyrotoxicosis, diabetes mellitus, heart
Budesonide 160 mcg and Formoterol Headache, insomnia, tremor, restlessness, oral Hypersensitivity to budesonide or formoterol or Itraconazole, ketoconazole, MAOI, tricyclic
Symbicort Mild, moderate and severe persistent asthma daily. ADOLESCENT (12 - 17 years) : 1 - 2 puff twice disease, hypokalaemia, severe cardiovascular
4.5 mcg Inhalation candidiasis, cough, hoarseness inhaled lactose antidepressan, ritonavir, phenothiazines
daily. CHILD less than 6 years are not recommended disorders, hypertropic obstructive cardiomyopathy,
tuberculosis, phaeocromocytoma
ADULT : 200 - 1600 mcg daily in 2 - 4 divided doses. generally reversible hoarseness of the voice.
Maintenance treatment of asthma as prophylactic mucous viscosity and mucous plugging. Caution in enhanced by the concomitant use. Amiodarone -
Maintenance with twice daily dosing. CHILD more than Bad taste, dryness of the throat. Candidiasis of Hypersensitivity to budesonide. Moderate to
Budesonide 200 mcg/dose Inhalation Pulmicort therapy especially if not fully controlled by viral infections such as varicella, in untreated fungal increased risk of developing Cushing's
7 years 200 - 800 mcg, 2 - 7 years 200 - 400 mcg. To the mouth and throat, paradoxical severe bronchiectasis
bronchodilators and bacterial infections of the respiratory system. syndrome. Ketoconazole, erytromycin, ritonavir -
be taken orally in 2 - 4 divided doses bronchoconstriction, headache, nausea,
generally reversible hoarseness of the voice.
Maintenance treatment of asthma as prophylactic ADULT : Initially 1 - 2 mg twice daily. CHILD 3 months - mucous viscosity and mucous plugging. Caution in enhanced by the concomitant use. Amiodarone -
Budesonide 500 mcg/2 ml Nebulising Bad taste, dryness of the throat. Candidiasis of Hypersensitivity to budesonide. Moderate to
Pulmicort therapy especially if not fully controlled by 12 years of age : 500 mcg - 1 mg. Maintenance dose : viral infections such as varicella, in untreated fungal increased risk of developing Cushing's
Solution the mouth and throat, paradoxical severe bronchiectasis
bronchodilators half of the above doses and bacterial infections of the respiratory system. syndrome. Ketoconazole, erytromycin, ritonavir -
bronchoconstriction, headache, nausea,
ADULT and CHILD 6 years and older. Rhinitis : 2 spray Nasal irritation, nose bleeding, dryness of throat, Erythromycin, clarithromycin, lansoprazole,
Severe fungal and viral nasal infections, chronic use, Severe nasal infection, recurrent nasal bleeding,
into each nostril once daily in the morning or 1 spray epistaxis, pharyngitis, cough, nasal irritation, amoxicillin, fluvoxamine, itraconazole,
Budesonide 64mcg Nasal Spray Rhinocort Aqua Seasonal allergic, perennial rhinitis and nasal polyposis liver cirrhosis, reduce liver function, pulmonary hypersensitivity to budesonide products, status
into each nostril twice daily. Nasal polyps : 2 spray bronchospasm, cataract, cushing's syndrome, ketoconazole, protease inhibitors, voriconazole,
tuberculosis, glaucoma, adrenal suppression asthmaticus or other acute episodes of asthma
twice daily glaucoma, secondary hypocortisolism cimetidine
Alterations in glucose metabolism, blood dyscrasias Amikacin, angiotensin converting enzyme

(thrombocytopenia), hepatic disease, inhibitors, digitoxin, digoxin, gentamicin,
IV injection: 1 - 2 mg repeated after 20 mins. IV Hypokalaemia, hyperuricaemia, muscle cramps, Hypersensitivity to bumetanide products, anuria,
Bumetanide 0.5 mg/ml Injection Burinex Oedema used in furosemide allergic patient hyperuricaemia, hypokalaemia, hypovolaemia, kanamycin, lithium, neomycin, netilmicin,
infusion: 2 - 5 mg over 30 - 60 mins arthralgias severe electrolyte imbalance, hepatic coma
ototoxicity particularly potentiation of aminoglycoside nonsteroidal antiinflammatory agents,
ototoxicity, coadministration not recommended streptomycin, tobramycin
Angiotensin converting enzyme inhibitors:
Alterations in glucose metabolism, blood dyscrasias
postural hypotension (first dose). Digoxin:
(thrombocytopenia), hepatic disease,
1 mg in the morning, repeat after 6 - 8 hours if Hypokalaemia, hyperuricaemia, muscle cramps, Hypersensitivity to bumetanide products, anuria, digoxin toxicity (nausea, vomiting, cardiac
Bumetanide 1 mg Tablet Burinex Oedema used in furosemide allergic patient hyperuricaemia, hypokalaemia, hypovolaemia,
necessary. Up to 5 mg daily in severe cases arthralgias severe electrolyte imbalance, hepatic coma arrhythmias). Gentamicin: ototoxicity.
ototoxicity particularly potentiation of aminoglycoside
Kanamycin: increased risk of ototoxicity
ototoxicity, coadministration not recommended
(tinnitus).
Light headedness, nervousness, apprehension,
euphoria, confusion, dizziness, drowsiness,
tinnitus, blurred vision, diplopia, nausea,
vomiting, sensations of heat, cold or numbness,
urinary retention, paraesthesia circumoral,
hyperacusis, twitching, tremors, convulsions,
Neurological disorder, serious CNS or spinal cord unconsciousness, resp depression and/or arrest,
diseases, hypoxaemia, acidosis, hyperkalaemia, agitation, numbness of tongue, difficulty in
predisposition to malignant hypothermia, pregnancy. swallowing & slurred speech. Cardiovascular:
Resuscitative equipment & drugs should be bradycardia, hypotension. Haemodynamic:
Hypovolaemia, complete heart block,
immediately available. Elderly, young or debilitated maternal hypotension. Neurologic: spinal block
intravenous regional anaesthesia (Bier's block).
patients, advanced liver disease, severe renal of varying magnitude (including total spinal
Allergy or hypersensitivity to amide type local Hyaluronidase, propofol, rapacuronium. May
Bupivacaine 0.125% Epidural Infuse at 6 - 15 ml/hour. Not to exceed 2 mg/kg in a impairment, children less than 12 year. Epilepsy, block), hypotension secondary to spinal block,
Marcaine Epidural Epidural analgesia for postoperative pain relief. anesth. Epidural or spinal anesth in patients with potentiate class III antiarrhythmics (eg mexiletine
Injection single dose. impaired cardiac conduction, bradycardia, severe loss of bladder & bowel control & loss of perineal
uncorrected hypotension. Infection and/or & lignocaine), verapamil
shock or digitalis intoxication, impaired sensation & sexual function. Persistent motor,
septicaemia. Obstetric paracervical block, IV
cardiovascular function, Stokes-Adams syndrome, sensory and/or autonomic (sphincter control)
regional anesth (Bier's block)
Wolff-Parkinson-White syndrome. Preexisting deficit of some lower spinal segments with slow
neurological or neuromuscular disease, recovery (several month) or incomplete recovery
hyperthyroidism. May temporarily impair locomotion in rare instances when caudal/lumbar epidural
or coordination block has been attempted. Backache &
headache. Neuropathy, peripheral nerve injury &
arachnoiditis. Inadvertent subarachnoid inj may
lead to Central nervous system depression, resp
arrest & cardivascular collapse. Allergic:
cutaneous lesions, urticaria, oedema or
anaphylactoid reactions.

Neurological disorder, severe bradycardia, cardiac intravenous regional anaesthesia (Bier's block).
conduction abnormalities, hypoxaemia, acidosis, Acute active disease of the CNS eg meningitis,
hyperkalaemia, predisposition to malignant tumours, poliomyelitis & cranial haemorrhage,
hypothermia, pregnancy. Resuscitative equipment & Confusion, nervousness, dizziness, tinnitus, active TB or metastatic lesions in the vertebral
Marcaine Spinal ADULT: 2 - 4 ml. Not to exceed 2 mg/kg in a single Hyaluronidase, propofol, rapacuronium,
Bupivacaine 0.5 % Heavy Injection Used for spinal anaesthesia drugs should be immediately available. respiratory depression and convulsion, column. Septicaemia. Pernicious anaemia with
Heavy dose verapamil, antiarrhythmias.
Hypovolaemia due to haemorrhage or dehydration, hypotension and bradycardia, hypersensitivity subacute combined degeneration of the spinal
aortocaval occlusion, coronary or cerebrovascular cord. Pyrogenic infection of the skin at or
disease. Chronic neurological disorders. May impair adjacent to the site of puncture. Cardiogenic or
ability to drive or operate machinery hypovolaemic shock. Coagulation disorders or
ongoing anticoagulant treatment
intravenous regional anaesthesia (Bier's block).
Acute active disease of the CNS eg meningitis,
Confusion, nervousness, dizziness, tinnitus,
tumours, poliomyelitis & cranial haemorrhage,
Regional nerve block or epidural block: 15 - 30 ml. Neurological disorder, severe bradycardia, cardiac respiratory depression and convulsion,
For peripheral sympathetic nerve and epidural active TB or metastatic lesions in the vertebral
Nerve block of finger or toe: 2 - 6 ml. Maximum: 2 conduction abnormalities, hypoxaemia, acidosis, hypotension and bradycardia, hypersensitivity, Hyaluronidase, propofol, rapacuronium,
Bupivacaine 0.5 % Injection Marcaine (excluding caudal) anaesthesia and obstetrics column. Septicaemia. Pernicious anaemia with
mg/kg body weight in any 4 hours period, equivalent to hyperkalaemia, predisposition to malignant arrhythmias and cardiac arrest; verapamil, antiarrhythmias
anaesthesia subacute combined degeneration of the spinal
25 - 30 ml in adults of average weight hypothermia, pregnancy methemoglobinaemia; seizures, restlessness.
cord. Pyrogenic infection of the skin at or
Prolonged block
adjacent to the site of puncture. Cardiogenic or
hypovolaemic shock. Coagulation disorders or
ongoing anticoagulant treatment
Preexisting neurological or neuromuscular disease

eg myasthenia gravis; CNS or spinal cord disease
eg meningitis, spinal fluid block, cranial or spinal
haemorrhage, tumours, poliomyelitis, syphilis, TB or
Light headedness, nervousness, apprehension,
metastatic lesions of the spinal cord, severe hepatic
euphoria, confusion, drowsiness, tinnitus, blurred
disease, severe renal dysfunction, hyperthyroidism,
vision, diplopia, nausea, vomiting, sensations of
epilepsy, severe bradycardia, severe cardiac
heat, cold or numbness, urinary retention,
conduction abnormalities, severe shock or digitalis
paraesthesia circumoral, hyperacusis, twitching,
intoxication, Stokes-Adams or Wolff-Parkinson-
tremors, convulsions, unconsciousness, resp
White syndrome, hypoxaemia, acidosis,
depression &/or arrest, agitation, numbness of May potentiate the cardiac effects of
hyperkalaemia, predisposition to malignant Allergy or hypersensitivity to amide type local
the tongue, difficulty in swallowing & slurred antiarrhythmics (eg mexiletine & lignocaine).
hypothermia, fetal bradycardia/tachycardia anesth. Epidural or spinal anesth in patients with
speech. CV: bradycardia, hypotension: CNS acting drugs: tricyclic antidepressants or
frequently follows paracervical block with some uncorrected hypotension. Infection and/or
Haemodynamic: maternal hypotension. MAOIs, phenothiazines & butyrophenones.
amide type local anesth & may be associated with septicaemia. Obstetric paracervical block, IV
10 - 40 ml (0.25 %) or maximum : 2 mg/kg body weight Neurologic: spinal block of varying magnitude Oxytocic drugs of the ergot type. Adrenergic
Bupivacaine 0.5 % with Adrenaline fetal acidosis & hypoxia. Added risk in prematurity, regional anesth (Bier's block). Thyrotoxicosis;
Marcaine-Adrenaline Regional nerve block or epidural block. in any 4 hours period, equivalent to 25 - 30 ml of 0.5% (including total spinal block), hypotension neuron blocking agents eg guanethidine,
1:200,000 Injection toxaemia of pregnancy & fetal distress. Monitor fetal regions with compromised blood supply,
solution secondary to spinal motor, sensory &/or debrisoquine, bethanidine. β-blocker eg
heart rate. Pregnancy. Allergic type reactions extremities. severe hemorrhage, severe
autonomic (sphincter control) deficit of some propranolol. Inhalation anesth eg chloroform,
including anaphylactic type symptoms & life- hypotension or shock and arrhythmias, such as
lower spinal segment w/ slow recovery (several halothane, cyclopropane, trichloroethylene or
threatening or less severe asthmatic episodes in complete heart block, which severely restrict
mth) or incomplete recovery in rare instances other halogenated cmpds. Cardiac glycosides,
certain susceptible people. Extreme caution in cardiac output (spinal anesthesia)
when caudal or lumbar epidural block has been quinidine, hypoglycaemics
patients with severe or untreated hypertension,
attempted. Backache & headache. Neuropathy,
poorly controlled thyrotoxicosis, ischaemic heart
peripheral nerve injury & arachnoiditis.
disease, heart block, cerebrovascular insufficiency,
Inadvertent subarachnoid inj may lead to CNS
advanced diabetes & any other pathological
depression, resp arrest & CV collapse. Allergic:
condition that might be aggravated by effects of
cutaneous lesions, urticaria, oedema or
adrenaline. Adrenaline may induce anginal pain in
anaphylactoid reactions
patients suffering from ischaemic heart disease.
Ventricular fibrillation, prefibrillatory rhythm,
tachycardia, myocardial infarction, phenothiazine-
induced circulatory collapse & prostatic hypertrophy
i) ADULT: Initial: 2 - 4 mg daily. Maintenance: 0.5 - 2 Myelosuppression, cataracts, hyperpigmentation,
mg daily. Stop when white blood cell less than 20 x diffuse interstitial pulmonary fibrosis,
i) Chronic myeloid leukaemia (CML) and other 109/L. CHILD: 60 mcg/kg body weight daily ii) CHILD: Monitor blood counts during therapy. Caution in gastrointestinal disturbances, veno-occlusive
Hypersensitivity to busulphan. Pregnancy and
Busulphan 2 mg Tablet Myleran myeloproliferative diseases ii) Haemopoietic stem cell Induction 60 mcg/kg body weight daily (maximum 4 mg) patients given radiotherapy or cytotoxic drug therapy disease, gynaecomastia, convulsions, impaired Itraconazole, paracetamol, live vaccines
lactation
transplant (HSCT)- refer to specific protocols if leucocytes more than 20,000/mm3 and platelets more recently fertility and gonadal function, endocardial
than 100,000/mm3. Maintenance 10 - 30mcg/kg fibrosis, adrenal suppression, secondary
(maximum 2 mg daily) malignancy
Orthostatic hypotension, valvular regurgitation,
Eclampsia, pre-eclampsia or pregnancy induced abdominal pain, vertigo, pleural effusion,
i) Hyperprolactinaemia: 0.25 mg 1-2 times per week ii) Hypersensitivity to cabergoline or potent
i) Treatment of hyperprolactinaemic disorders ii) hypertension. Do not administer dopamine D2 pulmonary fibrosis, constipation, nausea, Activity and tolerability may be affected by
HIV mothers only: Prevent lactation 2 tab first day after inhibitors of CYP3A4 (includes protease
Cabergoline 0.5 mg Tablet Dostinex Prevention of puerperal lactation and suppression of receptor antagonists concurrently. High initial doses dizziness, headache, somnolence, depression, antiemetics, antihypertensives, psychotropics
delivery. Interruption of lactation: 0.25 mg 12 hourly for inhibitors, azole antifungals and some macrolide
lactation in HIV infected mothers only (1mg), especially with concurrent antihypertensive fatigue, sleeplessness, dyspepsia, gastritis, and macrolide antibiotics
2 days antibiotics), uncontrolled hypertension
regimens, liver disease weakness, fatigue, constipation, vomiting, breast
pain, hot flushes, depression, tingling
Avoid contact with eyes and other mucous
Calamine Cream - Prickly heat or insect bites Apply to the affected area as required Rash or irritation Not known Not known
membranes
Apply to the skin as required and allow to dry, 1-3 times Avoid contact with eyes and other mucous
Calamine Lotion - Prickly heat or insect bites Rash or irritation Not known. Not known
daily membranes
Calamine with 0.25 - 0.5% Menthol Apply to the skin as required and allow to dry, 1 - 3
- Prickly heat or insect bites membranes. Do not use on children under 2 years Rash or irritation Not known Not known
Lotion times daily
without consulting a physician
Aviod contact with eyes and other mucous
membranes. Do not use on children under 2 years
Calamine with 0.5% Phenol Cream - For use as a mild astringent Apply to the affected area as required Rash or irritation Pregnancy, paediatrics and geriatrics Not known
without consulting a physician. Should not be applied
to large areas of skin or large wounds
Calamine with 2 - 6% Precipitated Apply to the skin as required and allow to dry, 1 - 3
- Acne vulgaris membranes. Do not use on children under 2 years Rash or irritation Not known Not known
Sulphur Lotion times daily
without consulting a physician
Apply to the affected skin lesions twice daily.
Should not be used on the face since the formulation
Maintenance therapy may be achieved with less Transient local irritation and very rarely, facial Hypersensitivity to any constituents of the
Calcipotriol 50 mcg/g Cream Daivonex Only for the treatment of Psoriasis Vulgaris may give rise to irritation of the facial skin. Careful Not known
frequent application. The weekly dose should not dermatitis may occur, hypercalcaemia calcipotriol. Disorders of calcium metabolism
handwashing after use is recommended
exceed 100 g.
Apply to the affected skin lesions twice daily. Should not be used on the face since the ointment
Maintenance therapy may be achieved with less formulation may give rise to irritation of the facial Transient local irritation and very rarely, facial Hypersensitivity to any constituents of the
Calcipotriol 50 mcg/g Ointment Daivonex Only for the treatment of Psoriasis Vulgaris Not known
frequent application. The weekly dose should not skin. Careful handwashing after use is dermatitis may occur, hypercalcaemia calcipotriol. Disorders of calcium metabolism
exceed 100 g recommended
Apply to the affected skin lesions twice daily. Weekly
Should not be used on the face since the formulation
maintenance therapy may be achieved with less Transient local irritation and very rarely, facial Hypersensitivity to any constituents of the
Calcipotriol 50 mcg/ml Scalp Solution Diavonex Only for the treatment of Psoriasis Vulgaris may give rise to irritation of the facial skin. Careful Not known
frequent application. The weekly dose should not dermatitis may occur and hypercalcaemia calcipotriol. Disorders of calcium metabolism
handwashing after use is recommended
exceed 100 g
Disorders of calcium metabolism, viral, fungal or Alatrofloxacin, alcuronium, Amphotericin B

bacterial skin infections, parasitic infections, skin Liposome, Anthrax Vaccine Adsorbed, Anthrax
Calcipotriol Hydrate 50 mcg/g & Apply once daily up to 4 weeks with maximum weekly Avoid contact with face and eyes. Avoid application Pruritus, rash, local transient irritation, dermatitis,
manifestations in relation to tuberculosis or Vaccine Adsorbed, Bacillus of Calmette and
Betamethasone Dipropionate 0.5 Daivobet Resistant plaque psoriasis dose of 100g and maximum treatment area 30% of on large areas of damaged skin, under occlusive erythema, aggravation of psoriasis,
syphilis, rosacea, acne rosacea, perioral Guerin Vaccine Live, Carbamazepine,
mg/g Ointment body surface dressings or in skin folds. Pregnancy and lactation photosensitivity and hypersensitivity reactions
dermatitis, acne vulgaris, skin atrophy, striae Ciprofloxacin, Diphtheria Toxoid, Adsorbed,
atrophicae, fragility of skin Ethinyl Estradiol, Etonogestrel
5 - 10 IU/kg/day SC/IM (in 1 - 2 divided doses) to 400
Ketoprofen inhibit the calciuric and uricosuric
units every 6 - 8 hours adjusted according to clinical Nausea, vomiting, flushing, chills, dizziness,
Calcitonin (synthetic Salmon) 100 IU Pregnancy, lactation, caution when driving vehicles effects of calcitonin. Calcitonin cause a
Miacalcic Acute hypercalcaemia and biochemical response (no additional benefit with polyuria. Rarely, local hypersensitivity reactions, Hypersensitivity to calcitonin
Injection or operating machinery significant decrease in the mean values of lithium
over 8 units/kg every 6 hours. 5 - 10 units/kg slow IV anaphylactoid-like reactions
plasma levels
over at least 6 hours
Rhinitis, ulcerative rhinitis, sinusitis, epitaxis,
Pregnancy, lactation, caution when driving vehicles flushing, dizziness, headache, gastrointestinal Ketoprofen inhibit the calciuric and uricosuric
Calcitonin (Synthetic Salmon) 200 IU or operating machine. Should not be given to disturbances, musculoskeletal pain, pharyngitis, effects of calcitonin. Calcitonin cause a
Miacalcic Osteoporosis 200 units daily Hypersensitivity to calcitonin
Nasal Spray children more than a few weeks. Possibility of fatigue, dysgeusia. Rarely, hypertension, significant decrease in the mean values of lithium
systemic allergic reaction exists vomiting, arthralgia, cough, oedema, flu-like plasma levels
symptoms, abnormal vision
5 - 10 IU/kg/day SC/IM (in 1 - 2 divided doses) to 400
Ketoprofen inhibit the calciuric and uricosuric
units every 6 - 8 hours adjusted according to clinical Nausea, vomiting, flushing, chills, dizziness,
Calcitonin (Synthetic Salmon) 50 IU Pregnancy, lactation, caution when driving vehicles effects of calcitonin. Calcitonin cause a
Miacalcic Acute hypercalcaemia and biochemical response (no additional benefit with polyuria. Rarely, local hypersensitivity reactions, Hypersensitivity to calcitonin
Injection or operating machinery significant decrease in the mean values of lithium
over 8 units/kg every 6 hours. 5 - 10 units/kg slow IV anaphylactoid-like reactions
plasma levels
over at least 6 hours
i) 0.25 mcg 2 times daily ii) Initial dose 0.25 mcg. In Monitor serum calcium, phosphorus, magnesium
Treatment of: i) Postmenopausal osteoporosis ii) Renal patients with normal or only slightly reduced serum and alkaline phosphatase, urinary calcium and Hypercalcaemia, nausea, vomiting, polydipsia,
Hypercalcaemia, vitamin D toxicity, abnormal Cytochrome P450 effect. Cholestyramine,
osteodystrophy in patients on haemodialysis iii) calcium levels, doses of 0.25 mcg every other day is phosphorus. Patients on digitalis. Pregnancy and polyuria, weakness, headache, somnolence, dry
Calcitriol 0.25 mcg Capsule Rocaltrol sensitivity to the effects of vitamin D, thiazides diuretics, corticosteroids, magnesium-
Hypoparathyroidism and rickets iv) Secondary sufficient iii) 0.25 mcg/day given in the morning iv) lactation. Take care to ensure correct dose to mouth, constipation, muscle pain, bone pain,
malabsorption syndrome containing antacids, digitalis
hyperparathyroidism in renal failure ADULT and CHILD 3 years and older : Initially 0.25 infants, monitor plasma calcium and creatinine metallic taste
mcg/ml. CHILD less than 3 years : 10 to 15 ng/kg/day during dosage titration
Monitor serum calcium, phosphorus, magnesium
and alkaline phosphatase, urinary calcium and Hypercalcaemia, nausea, vomiting, polydipsia,
Management of hypocalcaemia and/or secondary Initially dose, depending on severity, 1 mcg (0.02 Hypercalcaemia, metastatic calcification, vitamin Cytochrome P450 effect. Cholestyramine,
phosphorus. Patients on digitalis. Pregnancy and polyuria, weakness, headache, somnolence, dry
Calcitriol 1 mcg/ml Injection Calcijex hyperparathyroidism in patients undergoing chronic mg/kg) to 2 mcg 3 times weekly, approximately every D toxicity and hypersensitivity to calcitriol thiazides diuretics, corticosteroids, magnesium-
lactation.Take care to ensure correct dose to infants, mouth, constipation, muscle pain, bone pain,
renal dialysis other day products containing antacids, digitalis
monitor plasma calcium and creatinine during metallic taste
dosage titration
Monitor serum calcium, phosphorus, magnesium
and alkaline phosphatase, urinary calcium and Hypercalcaemia, nausea, vomiting, polydipsia,
Management of hypocalcaemia and/or secondary Hypercalcaemia, metastatic calcification, vitamin Cytochrome P450 effect. Cholestyramine,
Initially dose, depending on severity, 1 mg (0.02 mg/kg) phosphorus. Patients on digitalis. Pregnancy and polyuria, weakness, headache, somnolence, dry
Calcitriol 2 mcg/ml Injection Calcijex hyperparathyroidism in patients undergoing chronic D toxicity and hypersensitivity to calcitriol thiazides diuretics, corticosteroids, magnesium-
to 2 mg 3 times weekly, approximately every other day lactation.Take care to ensure correct dose to infants, mouth, constipation, muscle pain, bone pain,
renal dialysis products containing antacids, digitalis
monitor plasma calcium and creatinine during metallic taste
dosage titration
Co-administration with thiazide diuretics or
vitamin D may lead to milk-alkali syndrome and
hypercalcaemia. Decreased absorption with
To be used only for elemental calcium supplementation Gastrointestinal irritation, constipation, flatulence, Patients with calcium renal calculi or history of corticosteroids. Decreases absorption of
Renal impairment, hypercalcaemia-associated
Calcium Carbonate 500 mg Capsule - and phosphate binding activity in patients with chronic Initial 2.5 g daily and increased up to 17 g daily gastric hypersecretion and acid rebound, renal calculi, hypercalcaemia, tetracyclines, atenolol, iron, quinolones,
disease eg, other malignancies, sarcoidosis, elderly
renal failure hypercalcaemia, alkalosis and renal dysfunction hypophosphataemia alendronate, natrium fluoride, zinc and calcium-
channel blockers. Enhances cardiac effects of
digitalis glycosides and may precipitate digitalis
intoxication
Co-administration with thiazide diuretics or
vitamin D may lead to milk-alkali syndrome and
hypercalcaemia. Decreased absorption with
To be used only for elemental calcium supplementation Gastrointestinal irritation, constipation, flatulence, Patients with calcium renal calculi or history of corticosteroids. Decreases absorption of
Renal impairment, hypercalcaemia-associated
Calcium Carbonate 500 mg Tablet and phosphate binding activity in patients with chronic Initial 2.5 g daily and increased up to 17 g daily gastric hypersecretion and acid rebound, renal calculi, hypercalcaemia, tetracyclines, atenolol, iron, quinolones,
disease eg, other malignancies, sarcoidosis, elderly
renal failure hypercalcaemia, alkalosis and renal dysfunction hypophosphataemia alendronate, natrium fluoride, zinc and calcium-
channel blockers. Enhances cardiac effects of
digitalis glycosides and may precipitate digitalis
intoxication
Renal impairment, haematuria, proteinuria, cerebral
Nephrotoxicity, malaise, chills, thirst, nausea,
60 - 70 mg/kg body weight daily given IV infusion in 2 oedema. Capable of producing toxic effects which
vomiting, diarrhoea, abdominal pain, injection
Calcium Disodium Edetate 200 mg daily doses for up to 5 days; repeated if necessary after can be fatal, patients with lead encephalopathy, Hypersensitivity to edetate products, anuria or
Ca Disod. Versenate Lead Poisoning site pain, myalgia, headache, hypotension Not known
Injection an interval of 2 days. Any further treatment with calcium administer only after adequate urine flow is active renal disease, hepatitis
(frequent), thrombophlebitis (frequent), immune
edetate should not be recommended for 7 days established, children must be given adequate oral
hypersensitivity reaction
fluids during outpatient therapy
i) 1-2 g (2.25-4.5 mmol). CHILD 50 mg/kg ii) ADULT 1g
Increased inotropic and toxic effects when used
i) Acute hypocalcaemia ii) Hypocalcaemic tetany iii) (2.2 mmol) by slow IV injection followed by continuous Extravasation during IV injection. Renal impairment, Sloughing or necrosis of the skin, soft tissue Hypercalcaemia, hypercalciurea, severe renal
Calcium Gluconate 10% Injection with cardiac glycosides. Complex formation with
Cardiac resuscitation infusion of 4 g (8.8 mmol) daily iii) IV or intracardiac cardiac disease or sarcoidosis calcification. Hypercalcaemia (excessive use) failure, patients treated with digitalis
tetracyclines
injection, 10 ml
Allopurinol, aspirin, chlorothiazide, ciprofloxacin,

Calcium enhances the effect of cardiac glycosides
digoxin, doxycycline, hydrochlorothiazide,
on the heart and may precipitate arrhythmias. In Ventricular fibrillation during cardiac
For prophylaxis of calcium deficiency and treatment of Mild gastrointestinal disturbances, bradycardia, itraconazole, ketoconazole, levothyroxine,
Calcium Lactate 300 mg Tablet - ADULT 1-5 g daily in divided doses large doses, monitor serum calcium concentration resuscitation, hypercalcaemia, hypercalciuria,
chronic hypocalcaemia arrhythmias metolazone, minocycline, norfloxacin, ofloxacin,
and kidney function weekly, renal impairment, severe renal failure
oxytetracycline, pefloxacin, tetracycline,
history of renal stones
ticlopidine, verapamil, zalcitabine
Digitalis preparation, antacid and laxatives
Patients should be monitored for electrolytes Bronchopneumonia associated with inhalation of Should be avoided in patients with conditions containing aluminium, magnesium or calcium,
15 - 30g daily in 2-3 divided doses. Each dose should disturbances, especially hypokalaemia and calcium polystyrene sulphonate. Anorexia, such as hyperparathyroidism, multiple myeloma, dried aluminium hydroxide gel, magnesium
Calcium Polystyrene Sulphonate Hyperkalemia resulting from acute or chronic renal
Kalimate be suspended in 30 - 50ml of water and administered hypercalcaemia. May cause perforation in intestine, nausea, vomiting, constipation, diarrhea, colon sarcoidosis, or metastatic carcinoma who may hydroxide, precipitate calcium carbonate.
Powder failure
orally necrosis in mucous membrane of intestine, large perforation, hypopotassaemia, calcium present with renal failure together with Calcium ions are released from the resin in the
intestine ulcer, colon necrosis overloading and hypercalcaemia hypercalcaemia gastrointestinal tract and this may reduce the
absorption of tetracycline given by mouth
i)Metastatic breast cancer in elderly and poor Myelosuppression, oedema, fatigue, fever,
i) & ii) 1250 mg/m2 twice daily (morning and evening)
performance status patients and refractory to taxanes Patient with bone marrow suppression, poor abdominal pain, palmar-plantar Hypersensitivity to capecitabine, fluorouracil or
for 2 weeks, every 21 days iii) Recommended for a total
Capecitabine 500 mg Tablet Xeloda ii) Metastatic colon cancer, first line in elderly and poor nutritional status, elderly patients (more than 80 erythrodysesthesia, dermatitis, nausea and any component of formulation, severe renal Warfarin
of 24 weeks (8 cycles of 2 weeks of drug administration
performance status patients iii) Colon cancer, adjuvant years), hepatic or renal dysfunction vomiting, stomatitis, anorexia, diarrhoea, impairment, pregnancy, lactation
and 1 week rest period
therapy for stage III (Duke's Stage C) following surgery constipation, paraesthesia
i) Initially 12.5 mg twice daily. Maintenance: 50 mg 2 - 3 Anaphylaxis during lipid apheresis with dextran Angioedema induced by other angiotensin
times daily, may be increased to maximum 450 mg/day sulfate membranes and during hymenoptera converting enzyme (ACE) inhibitors during prior May increase serum K with Kalium K-sparing
Rash, pruritus, flushing, angioedema, loss of
i) Hypertension ii) Congestive heart failure iii) Post- ii) Initially 6.25 - 12.5 mg 3 times daily, increase after desensitization, angioedema; discontinue if laryngeal exposure. Anuric renal failure during prior diuretics. Hypotensive effects enhanced by
Captopril 25 mg Tablet Capoten taste perception, stomatitis, gastrointestinal
myocardial infarction iv) Diabetic nephropathy several days to 25 - 50 mg 3 times daily iii) Initially 6.25 stridor or angioedema of the face, tongue, or glottis exposure to ACE inhibitors. Hypersensitivity to diuretics. Antihypertensive effect diminished by
irritation and abdominal pain, leucopenia, cough
mg daily, gradually increased to 37.5 mg daily in is observed, aortic stenosis, breast feeding period, this or any other ACE inhibitor. Pregnancy indomethacin, salicylates, NSAIDs
divided doses iv) 75 - 100 mg daily in divided doses cough, impaired renal function (second and third trimester pregnancy)
Retinal disease; conjunctival or corneal damage. Ciliary spasm leads to headache and browache
Intraocular pressure and visual fields should be which may be more severe in the initial 2 - 4 Contraindicated in conditions where pupillary
monitored in those with simple chronic glaucoma weeks of treatment. Ocular side effects include constriction is undesirable such as acute iritis,
Instill no more than 1/2 ml gently into the anterior
Carbachol 0.01% Intraocular Solution Miostat For intraocular use for miosis during surgery and those receiving long-term treatment with a burning, itching, smarting, blurred vision, anterior uveitis and some forms of secondary Not known
chamber
miotic. Caution in cardiac disease, hypertension, conjunctival vascular congestion, myopia, lens glaucoma. Acute inflammatory disease of the
asthma, peptic ulceration, urinary-tract obstruction changes with chronic use, vitreous anterior segment
and parkinson's disease haemorrhage, and pupillary block
Rash, Stevens-Johnson Syndrome, nausea,

ADULT: Initially, 100-200 mg once or twice daily drowsiness, dizziness, ataxia, blood dyscrasias,
Breast feeding, pregnancy, liver or kidney Plasma level is increased by erythromycin,
gradually increased by increments of 100-200 mg every confusion, agitation, visual disturbance,
dysfunction, increased intraocular pressure, history diltiazem, isoniazid, verapamil, fluoxetine,
2 week. Maintenance: 0.8-1.2 g daily in divided doses. constipation or diarrhoea, anorexia, leukopenia,
of cardiac damage, elderly patients, glaucoma, may Hypersensitivity to carbamazepine products or cimetidine and decreased by other antiepileptics
Carbamazepine 100 mg/5 ml (2% CHILD: 10-15 years: 0.6-1 g daily; 5-10 years: 400-600 blood disorders, Syndrome of inappropriate ADH
Tegretol Epilepsy exacerbate certain types of idiopathic epilepsy. tricyclic compounds, bone marrow suppression, and theophylline. May reduce alcohol tolerance
w/v) Syrup mg daily; 1-5 years: 200-400 mg daily; less than or (SIADH), cardiac conduction abnormalities,
Avoid abrupt discontinuation. Neonatal withdrawal porphyria. Concomitant MAOIs, pregnancy and antagonise the effects of non-depolarising
equal to 1 year: 100-200 mg daily. Alternatively, 10-20 gynaecomastia. Allergic skin reactions,
syndrome. Potential for an increase in risk of suicidal muscle relaxants. Cytochrome P450 3A4
mg/kg body weight daily in divided doses. Max: Adult: leukopenia, vomiting, accommodation disorders,
thoughts or behaviours inducers or inhibitors, oral contraceptive
1.6 g daily diplopia, raised liver enzymes, thrombocytopenia
and hyponatraemia, exfoliative dermatitis
Breast feeding, pregnancy, liver or kidney

dysfunction, increased intraocular pressure, history Rash, Stevens-Johnson Syndrome, nausea,
of cardiac damage, elderly patients, glaucoma, may drowsiness, dizziness, ataxia, blood dyscrasias,
Plasma level is increased by erythromycin,
ADULT: Initial, 200 mg twice daily for the first week, exacerbate certain types of idiopathic epilepsy. Initial confusion, agitation, visual disturbance,
diltiazem, isoniazid, verapamil, fluoxetine,
may increase dosage by 200 mg/day at weekly and periodic complete blood counts, liver function constipation or diarrhoea, anorexia, leukopenia,
Hypersensitivity to carbamazepine products or cimetidine and decreased by other antiepileptics
intervals until optimal response is obtained. Maximum tests and urinalysis. Monitor plasma levels. History blood disorders, Syndrome of Inappropriate ADH
Carbamazepine 200 mg CR Tablet Tegretol CR Epilepsy tricyclic compounds, bone marrow suppression, and theophylline. May reduce alcohol tolerance
1.6 g/day. CHILD: usual maximum dosage 1000 haematological reactions. Road/machinery users. (SIADH), cardiac conduction abnormalities,
porphyria. Concomitant MAOIs, pregnancy and antagonise the effects of non-depolarising
mg/day in children 12-15 years of age, 1200 mg/day in Increased intraocular pressure, latent psychosis, gynaecomastia. Allergic skin reactions,
muscle relaxants. Cytochrome P450 3A4
patients above 15 years of age confusion, agitation. Mixed seizure disorders. leukopenia, vomiting, accommodation disorders,
inducers or inhibitors, oral contraceptive
Elderly. Avoid abrupt discontinuation. Neonatal diplopia, raised liver enzymes, thrombocytopenia
withdrawal syndrome. Potential for an increase in and hyponatraemia, exfoliative dermatitis
risk of suicidal thoughts or behaviours
Rash, Stevens-Johnson Syndrome, nausea,

i) ADULT: 100 - 200 mg 1 - 3 times daily increased drowsiness, dizziness, ataxia, blood dyscrasias,
Breast feeding, pregnancy, liver or kidney Plasma level is increased by erythromycin,
gradually to usual dose of 0.8 - 1.2 g daily in divided confusion, agitation, visual disturbance,
dysfunction, increased intraocular pressure, history diltiazem, isoniazid, verapamil, fluoxetine,
doses. CHILD: Up to 1 year: 100 - 200 mg daily; 1 - 5 constipation or diarrhoea, anorexia, leukopenia,
of cardiac damage, elderly patients, glaucoma, may Hypersensitivity to carbamazepine products or cimetidine and decreased by other antiepileptics
yrs: 200 - 400 mg daily; 5 - 10 years: 400 - 600 mg blood disorders, Syndrome of Inappropriate ADH
Carbamazepine 200 mg Tablet Tegretol i) Epilepsy ii) Trigeminal neuralgia exacerbate certain types of idiopathic epilepsy. tricyclic compounds, bone marrow suppression, and theophylline. May reduce alcohol tolerance
daily; 10 - 15 years: 0.6 - 1 g daily ii) ADULT: Initially, (SIADH), cardiac conduction abnormalities,
Avoid abrupt discontinuation. Neonatal withdrawal porphyria. Concomitant MAOIs, pregnancy and antagonise the effects of non-depolarising
100 mg once or twice daily gradually increased as gynaecomastia. Allergic skin reactions,
syndrome. Potential for an increase in risk of suicidal muscle relaxants. Cytochrome P450 3A4
necessary. Maintenance: 400-800 mg daily in 2-4 leukopenia, vomiting, accommodation disorders,
thoughts or behaviours inducers or inhibitors, oral contraceptive
divided doses. Max: 1.2 g daily diplopia, raised liver enzymes, thrombocytopenia
and hyponatraemia, exfoliative dermatitis
Breast feeding, pregnancy, liver or kidney
dysfunction, increased intraocular pressure, history Rash, Stevens-Johnson Syndrome, nausea,
of cardiac damage, elderly patients, glaucoma, may drowsiness, dizziness, ataxia, blood dyscrasias,
Plasma level is increased by erythromycin,
ADULT: Initial, 200 mg twice daily for the first week, exacerbate certain types of idiopathic epilepsy. Initial confusion, agitation, visual disturbance,
diltiazem, isoniazid, verapamil, fluoxetine,
may increase dosage by 200 mg/day at weekly and periodic complete blood counts, liver function constipation or diarrhoea, anorexia, leukopenia,
Hypersensitivity to carbamazepine products or cimetidine and decreased by other antiepileptics
intervals until optimal response is obtained. Maximum tests and urinalysis. Monitor plasma levels. History blood disorders, Syndrome of Inappropriate ADH
Carbamazepine 400 mg CR Tablet Tegretol CR Epilepsy tricyclic compounds, bone marrow suppression, and theophylline. May reduce alcohol tolerance
1.6 g/day. CHILD: usual maximum dosage 1000 haematological reactions. Road/machinery users. (SIADH), cardiac conduction abnormalities,
porphyria. Concomitant MAOIs, pregnancy and antagonise the effects of non-depolarising
mg/day in children 12-15 years of age, 1200 mg/day in Increased intraocular pressure, latent psychosis, gynaecomastia. Allergic skin reactions,
muscle relaxants. Cytochrome P450 3A4
patients above 15 years of age confusion, agitation. Mixed seizure disorders. leukopenia, vomiting, accommodation disorders,
inducers or inhibitors, oral contraceptive
Elderly. Avoid abrupt discontinuation. Neonatal diplopia, raised liver enzymes, thrombocytopenia
withdrawal syndrome. Potential for an increase in and hyponatraemia, exfoliative dermatitis
risk of suicidal thoughts or behaviours
Avoid contact with eyes, discontinue use if oral
Contact irritant dermatitis, infantile eczemas, acute and Apply sparingly and rub into affected area 2 - 3 times inflammation persists or worsens. Use with caution
Carbamide (Urea) 10 % Cream Calmurid Skin irritation, rash and ischaemic skin necrosis Hypersensitivity to urea or any component Not known
chronic allergic eczemas, icthyosis, hyperkeratotic daily and when required after cleansing skin on inflammed skin or exudative lesions: irritation may
results
Nausea, vomiting, abdominal pain, pruritus,
Prevention of uterine atony and postpartum Given by IV 100 mcg as a single dose as soon as flushing, feeling of warmth, hypotension,
Hyponatraemia, cardiovascular disease (avoid if Pre-eclampsia and eclampsia, epilepsy, hepatic Vasoconstrictors in conjunction with caudal block
Carbetocin 100 mcg/ ml Injection Duratocin hemorrhage following elective cesarean section under possible after delivery, preferably before removal of headache, tremor, back pain, dizziness, metallic
severe), migraine, asthma impairment, renal impairment anaesthesia, cyclopropane anaesthesia
epidural or spinal anaesthesia placenta taste, anaemia, sweating, chest pain, dyspnoea,
chills, tachycardia, anxiety
Concurrent use of digoxin and carbimazole may
May be given to pregnant women. Treatment result in decreased peak serum levels of digoxin.
ADULT: Initially 10 - 60 mg daily in divided doses. Nausea, mild gastrointestinal disturbance, should be discontinued 3 - 4 weeks before Antithyroid drugs, by reducing the extent of
Carbimazole 5 mg Tablet Neo-mercazole Hyperthyroidism Liver disorders, pregnancy, breast feeding
Maintenance: 5 - 20 mg daily rashes, bone marrow supression delivery. Infants should not breast fed by hyperthyroidism, decrease the metabolism of
mothers taking carbimazole clotting factors and thus reduce the effects of
oral anticoagulants
360 - 400 mg/m2 BSA, by IV infusion over 15 mins to 1
hour on Day 1 every 4 weeks. Alternatively, Myelosuppression, renal impairment. Monitor blood Nephrotoxic and ototoxic drugs, phenytoin. If
Myelosuppression, alopecia, mucositis, Hypersensitivity to cisplatin/ platinum products or
Adult solid tumours, paediatric tumours. Salvage prescription may be based on Area Under Curve (AUC) counts and renal function. Do not use infusion sets platinum compound is used with taxane, to be
Carboplatin 150 mg Injection Paraplatin electrolyte disturbances, nausea and vomiting, mannitol, pregnancy, lactation, severe
therapy for lymphoma calculations. CHILD: 500-600 mg/m2 over 1 hour once or needles containing aluminium, avoid given after taxane. Increased risk of infection by
nephrotoxicity, ototoxicity, peripheral neuropathy myelosuppression
every 3 weeks. Salvage regimes in lymphomas - refer extravasation live vaccines, zidovudine
to specific protocols
360 - 400 mg/m2 BSA, by IV infusion over 15 mins to 1
hour on Day 1 every 4 weeks. Alternatively, Myelosuppression, renal impairment. Monitor blood Nephrotoxic and ototoxic drugs, phenytoin. If
Myelosuppression, alopecia, mucositis, Hypersensitivity to cisplatin/ platinum products or
Adult solid tumours, paediatric tumours. Salvage prescription may be based on Area Under Curve (AUC) counts and renal function. Do not use infusion sets platinum compound is used with taxane, to be
Carboplatin 450 mg Injection Paraplatin electrolyte disturbances, nausea and vomiting, mannitol, pregnancy, lactation, severe
therapy for lymphoma calculations. CHILD: 500-600 mg/m2 over 1 hour once or needles containing aluminium, avoid given after taxane. Increased risk of infection by
nephrotoxicity, ototoxicity, peripheral neuropathy myelosuppression
every 3 weeks. Salvage regimes in lymphomas - refer extravasation live vaccines, zidovudine
to specific protocols
Glaucoma, elevated intraocular pressure, asthma or
history of asthma. Cephalopevic relationships
carefully evaluated prior to use. During use, uterine
ADULT: by deep IM injection; 250 mcg, may repeat at
activity, foetal status and the progression of cervical Nausea, vomiting and diarrhoea, paraesthesia,
15-90 minute, intervals to a total dose of 2 mg (8 Hypersensitivity to prostagladin, acute pelvic
Carboprost Tromethamine 250 mcg dilation evaluated at frequent intervals. In patients fever or chills, dystonia, breast tenderness,
Hemabate Postpartum haemorrhage refractory to oxytocin doses), followed by subsequent doses of 250 mcg at inflammatory disease, cardiac, renal, pulmonary Not known
Injection with history of hypertonic uterine contractility or hyperthermia and flushing, bronchospasm,
intervals of 1.5 to 3.5 hours. Dosage may be increased or hepatic disease
tetanic uterine contractions, recommended that cardiovascular collapse
to 500 mcg/dose if contractility is inadequate
uterine activity and state of foetus be monitored
throughout labour. Possible uterine rupture where
high tone myometrical contractions are sustained
Myocardial temperature should be monitored during

surgery to maintain hypothermia. Continuous
Dilute 20 ml to 1 L of Ringer solution (cooled to 2-8 °C
electrocardiogram monitoring is essential to detect
Cardioplegia solution containing prior to use). Initial rapid instillation into aortic root at Myocardial infarction, electrocardiographic Incompatible with aminophylline, barbiturates,
For myocardial preservation(prevent myocardial changes in myocardial activity during the procedure.
Potassium Chloride, Magnesium - 300 ml/m² body surface area/min for 3 minutes. Should abnormalities and arrhythmias including Not for intravenous injection magnesium sulphate, phenytoin sodium, sodium
damage) during cardiac surgery Appropriate equipment to defibrillate the heart
chloride & Procaine HCl Injection myocardial activity persist or recur instill at 300ml/m² ventricular fibrillation bicarbonate, amikacin, amphotericin, dobutamine
following cardioplegia should be readily available.
body surface area/min for 2 minutes
Inotropic support drugs should be available during
postoperative recovery
Hypotensive effects potentiated by adrenergic
Hypersensitivity to carvedilol, asthma, neurone-blocking drugs, catecholamine
3.125 mg twice daily for 2 weeks, then 6.25 mg twice Avoid abrupt withdrawal, gradual withdrawal over a
bradycardia, 2nd and 3rd degree AV block, depletors, central nervous system depressants,
Treatment of stable moderate to severe congestive daily for 2 weeks, then 12.5 mg twice daily for 2 weeks period of 1 to 2 weeks is recommended. Dizziness, headache, tiredness, gastrointestinal
Carvedilol 25 mg Tablet Dilatrend cardiogenic shock overt cardiac failure, diuretics and vasodilators. Action decreased by
cardiac failure in addition to ACEI's and diuretics then 25 mg twice daily (titrated up to the highest Bronchospastic disease, congestive heart failure, disorders, flu-like symptoms
obstructive airway disease, severe chronic heart rifampicin. Concurrent administration with
tolerated level) diabetes mellitus
failure and hepatic impairment cardiac glycosides may cause a sharp drop in
heart rate
Hypotensive effects potentiated by adrenergic
Hypersensitivity to carvedilol, asthma, neurone-blocking drugs, catecholamine
3.125 mg twice daily for 2 weeks, then 6.25 mg twice Avoid abrupt withdrawal, gradual withdrawal over a
bradycardia, 2nd and 3rd degree AV block, depletors, central nervous system depressants,
Treatment of stable moderate to severe congestive daily for 2 weeks, then 12.5 mg twice daily for 2 weeks period of 1 to 2 weeks is recommended. Dizziness, headache, tiredness, gastrointestinal
Carvedilol 6.25 mg Tablet Dilatrend cardiogenic shock overt cardiac failure, diuretics and vasodilators. Action decreased by
cardiac failure in addition to ACEI's and diuretics then 25 mg twice daily (titrated up to the highest Bronchospastic disease, congestive heart failure, disorders, flu-like symptoms
obstructive airway disease, severe chronic heart rifampicin. Concurrent administration with
tolerated level) diabetes mellitus
failure and hepatic impairment cardiac glycosides may cause a sharp drop in
heart rate
Invasive aspergillosis & invasive candidiasis: ADULT:
Concomitant ciclosporine; use only if benefits Fever, nausea, vomiting, flushing, rash,
Initially, 70 mg infused over 1 hour followed by Tacrolimus, cyclosporine, inducer of drug
Confirmed systemic fungal infection in patients who are outweigh risk of possible hepatic toxicity, liver dyspnoea, dystonia, facial swelling, pruritus,
Caspofungin Acetate 50 mg Injection Cancidas subsequent doses of 50 mg/day. Oesophageal Hypersensitivity to caspofungin acetate clearance (e.g. efavirenz, nevirapine, rifampicin,
refractory or intolerant to other fungal therapies impairment, myelosuppression, pregnancy, lactation, increased liver enzymes, complication of
candidiasis: ADULT: 50 mg by slow IV infusion over dexamethasone, phenytoin, carbamazepine)
renal insufficiency infusion, thrombophlebitis, headache
approximately 1 hour
Invasive aspergillosis & invasive candidiasis: ADULT:
Concomitant ciclosporine; use only if benefits Fever, nausea, vomiting, flushing, rash,
Initially, 70 mg infused over 1 hour followed by Tacrolimus, cyclosporine, inducer of drug
Confirmed systemic fungal infection in patients who are outweigh risk of possible hepatic toxicity, liver dyspnoea, dystonia, facial swelling, pruritus,
Caspofungin Acetate 70 mg Injection Cancidas subsequent doses of 50 mg/day. Oesophageal Hypersensitivity to caspofungin acetate clearance (e.g. efavirenz, nevirapine, rifampicin,
refractory or intolerant to other fungal therapies impairment, myelosuppression, pregnancy, lactation, increased liver enzymes, complication of
candidiasis: ADULT: 50 mg by slow IV infusion over dexamethasone, phenytoin, carbamazepine)
renal insufficiency infusion, thrombophlebitis, headache
approximately 1 hour
Infections caused by susceptible organisms including
Probenecid, oral anticoagulants, bacteriostatic
Staphylococcus aureus and H. influenzae, treatment of 20 - 40 mg/kg body weight daily in 3 divided doses. Penicillin-sensitive patients, history of GI disease, Blood disorders, GI disturbances, CNS effects,
Cefaclor 125 mg/5 ml Suspension Ceclor, Distaclor Hypersensitivity to cephalosporins antibiotics may reduce cephalosporin
sinusitis and infections involving the respiratory tract, Maximum: 1 g daily impaired renal function allergic skin reactions
effectiveness
skin and skin structure, bone and joint, and urinary tract
i) 375 mg twice daily ii) 375 mg or 500 mg twice daily iii) Probenecid, oral anticoagulants, bacteriostatic
i) Adult pharyngitis, tonsillitis, skin& soft tissue Penicillin-sensitive patients, history of GI disease, Blood disorders, GI disturbances, CNS effects,
Cefaclor 375 mg MR Tablet Distaclor 750mg twice daily iv) 375mg twice daily or 500 mg Hypersensitivity to cephalosporins antibiotics may reduce cephalosporin
infections ii) Bronchitis iii) Pneumonia iv) Lower UTI impaired renal function allergic skin reactions
once daily effectiveness
Infections caused by susceptible organisms including ADULT: 250 mg 3 times daily for 10 days. For severe
Probenecid, oral anticoagulants, bacteriostatic
Staphylococcus aureus and H. influenzae, treatment of infections, double the dosage. Maximum: 4 g daily. Penicillin-sensitive patients, history of GI disease, Blood disorders, GI disturbances, CNS effects,
Cefaclor 500 mg Capsule Ceclor, Distaclor Hypersensitivity to cephalosporins antibiotics may reduce cephalosporin
sinusitis and infections involving the respiratory tract, CHILD: 20 - 40 mg/kg body weight daily in 3 divided impaired renal function allergic skin reactions
effectiveness
skin and skin structure, bone and joint, and urinary tract doses. Maximum: 1 g daily
Drug induced fever, reddening of skin with heat

Infection caused by cefazolin-sensitive microorganism, ADULT: Uncomplicated infections: 500 - 1000 mg 2 - 3 sensation, angioneurotic edema, itch, Steven
infection of the respiratory tract, urogenital tract, skin times daily. Moderately severe and severe infections: Allergic, diathesis with bronchial asthma or hay Johnson Syndrome, urticaria, eosinophilia,
Cefazolin Sodium 1 g Injection Cefazolin Sandoz and soft tissue, bile duct, bones and joint, endocarditis, 500 - 1000 mg 3 - 4 times daily. Severe life-threatening fever, history of GI disease, renal impairment, allergic nephritis, GI disturbances, anaphylactic Hypersensitivity to cephalosporins Warfarin, probenecid
systemic septic infection, peri-operative/ surgical infections: 1 - 1.5 g 4 times daily. Rarely, dose up to 12 pregnancy and lactation reactions. Pseudomembranous enterocolitis,
prophylaxis g daily leukopenia, thrombocytopenia, neutropenia and
hepatotoxicity
Febrile neutropenia, septicaemia, lower respiratory
ADULT: 1 - 2 g twice daily for most infections. For Hypensensitivity, pseudomembranous colitis& GI disturbances (diarrhoea, nausea, vomiting),
tract infection, urinary tract infection, skin and skin Hypersensitivity to cephalosporins, penicillins or
Cefepime 1 g Injection Maxipime severe infections including febrile neutropenia: 2 g 3 superinfection may occur. Discontinue therapy if history of colitis, hypersensitivity, respiratory and Typhoid vaccine
structure infections, gynaecologic and intra-abdominal other beta-lactam antibiotics
times daily. CHILD: 25 - 50 mg/kg 3 times daily allergic reaction occurs. Pregnancy, lactation CNS disorders including headache, vaginitis
infections
Febrile neutropenia, septicaemia, lower respiratory
ADULT: 1 - 2 g twice daily for most infections. For Hypensensitivity, pseudomembranous colitis& GI disturbances (diarrhoea, nausea, vomiting),
tract infection, urinary tract infection, skin and skin Hypersensitivity to cephalosporins, penicillins or
Cefepime 500 mg Injection Maxipime severe infections including febrile neutropenia: 2 g 3 superinfection may occur. Discontinue therapy if history of colitis, hypersensitivity, respiratory and Typhoid vaccine
structure infections, gynaecologic and intra-abdominal other beta-lactam antibiotics
times daily. CHILD: 25 - 50 mg/kg 3 times daily allergic reaction occurs. Pregnancy, lactation CNS disorders including headache, vaginitis
infections
ADULT: 1 - 2 g twice daily IM or IV. By IV, adult dose
Hypersensitivity reactions eg. rash, urticaria,
may be doubled. Maximum: 16 g daily in divided doses. Penicillin-sensitive patients, severe biliary
fever, neutropenia (reversible),
Cefoperazone Sodium 1 g Injection Cefobid Infections due to gram-negative bacteria CHILD & INFANT: 50 - 200 mg/kg/day in 2 - 4 divided obstruction, severe hepatic disease or coexisting Hypersensitvity to cephalosporins Heparin, typhoid vaccine, warfarin
hypothrombinaemia, GI effects & local reactions,
doses. NEONATE less than 8 days: 50 - 200 mg/kg/day renal dysfunction
vitamin K deficiency
12 hourly
fever, neutropenia (reversible),
Cefoperazone Sodium 2 g Injection Cefobid Infections due to gram-negative bacteria CHILD & INFANT: 50 - 200 mg/kg/day in 2 - 4 divided obstruction, severe hepatic disease or coexisting Hypersensitvity to cephalosporins Heparin, typhoid vaccine, warfarin
hypothrombinaemia, GI effects & local reactions,
12 hourly
i) Treatment of infections due to multi-drug resistance Hepatic dysfunction& concomitant renal impairment,
Cefoperazone Sodium 500 mg & Diarrhoea, nausea, vomiting, maculopapular Known allergy to penicillins, sulbactam or
Sulperazon pathogens producing B-lactamase ii) Treatment of ADULT: 1 - 2 g twice daily. CHILD: 40 - 80 mg/kg/day ingestion of alcoholic beverages; overgrowth of Heparin, typhoid vaccine, warfarin
Sulbactam Sodium 500 mg Injection rash, urticaria; eosinophilia; drug fever cephalosporins
infections caused by Acinetobacter species nonsusceptible organisms
Cefoperazone Sodium 500 mg fever, neutropenia (reversible),
Cefobid Infections due to gram-negative bacteria CHILD & INFANT: 50 - 200 mg/kg/day in 2 - 4 divided obstruction, severe hepatic disease or coexisting Hypersensitvity to cephalosporins Heparin, typhoid vaccine, warfarin
Injection hypothrombinaemia, GI effects & local reactions,
12 hourly
Rash, pruritus, diarrhoea, nausea, vomiting,
Hypersensitivity to penicillins, history of
ADULT: 1 g 12 hourly (up to 12 g/day in severe cases). colitis, thrombocytopenia, eosinophilia,
Cefotaxime 1 g Injection Claforan Infections due to gram-negative bacteria gastrointestinal disease especially colitis, pregnancy Hypersensitivity to cephalosporins Aminoglycosides, probenecid, typhoid vaccine
CHILD: 50 - 180 mg/kg/day in 4 - 6 divided doses leucopenia, hypersensitivity reactions, GI effects,
& lactation
anaphylactic shock(rare)
Rash, pruritus, diarrhoea, nausea, vomiting,
Hypersensitivity to penicillins, history of
ADULT: 1 g 12 hourly (up to 12 g/day in severe cases). colitis, thrombocytopenia, eosinophilia,
Cefotaxime 500 mg Injection Claforan Infections due to gram-negative bacteria gastrointestinal disease especially colitis, pregnancy Hypersensitivity to cephalosporins Aminoglycosides, probenecid, typhoid vaccine
CHILD: 50 - 180 mg/kg/day in 4 - 6 divided doses leucopenia, hypersensitivity reactions, GI effects,
& lactation
anaphylactic shock(rare)
GI upsets, CNS effects, phlebitis or
ADULT: 1 g 8 hourly or 2 g 12 hourly. In severe thrombophlebitis at the IV injection site, pain
Aminoglycosides, probenecid, chloramphenicol,
Ceftazidime 1 g Injection Fortum Severe gram negative bacterial infections infections: 2 g 8 hourly. CHILD: 25 - 150 mg/kg/day in 2 Hypersensitivity to penicillins, renal impairment and/or inflammation after IM injection, very rarely Hypersensitivity to cephalosporins
live typhoid vaccine
- 3 divided doses hypersensitivity reactions. Transient
haematologicals changes
Ceftazidime 2 g Injection Fortum Severe gram negative bacterial infections infections: 2 g 8 hourly. CHILD: 25 - 150 mg/kg/day in 2 Hypersensitivity to penicillins, renal impairment and/or inflammation after IM injection, very rarely Hypersensitivity to cephalosporins
Ceftazidime 250 mg Injection Fortum Severe gram negative bacterial infections infections: 2 g 8 hourly. CHILD: 25 - 150 mg/kg/day in 2 Hypersensitivity to penicillins, renal impairment and/or inflammation after IM injection, very rarely Hypersensitivity to cephalosporins
Ceftazidime 500 mg Injection Fortum Severe gram negative bacterial infections infections: 2 g 8 hourly. CHILD: 25 - 150 mg/kg/day in 2 Hypersensitivity to penicillins, renal impairment and/or inflammation after IM injection, very rarely Hypersensitivity to cephalosporins
Previous hypersensitivity to penicillins, anaphylactic
shock, severe renal& hepatic failure, pregnancy.
Ceftriaxone and calcium -containing solutions may
be administered sequentially to one another if the
infusion lines are thoroughly flushed between
Hypersensitivity to cephalosporins. Neonates
infusions with compatible fluid. Diluents containing
aged less than or 28 days if they require
calcium (Ringer's / Hartmann's solution) are not to GI upsets, haematological changes, skin
i) 250 mg by deep IM injection ii) single IM injection 250 treatment with calcium-containing intravenous
Ceftriaxone 0.25 g Injection Rocephin i) Gonorrhoea ii) Chancroid be used to reconstitute ceftriaxonevials or to further reactions, coagulation disorders, phlebitis, Ciclosporin, typhoid vaccine
mg only. For severe infection up to 100 mg/kg/day solutions, including calcium-containing infusions
dilute a reconstituted vial for IV administration agranulocytosis, renal precipitations
such as parenteral nutrition, because of the risk
because a precipitate can form. Ceftriaxone must not
of precipitation of ceftriaxone-calcium
be administered simultaneously with calcium-
containing intravenous solutions, including continous
calcium -containing infusions such as parenteral
nutrition via a Y-site, because precipaitation of
ceftriaxone-calcium can occur
ADULT: 1 - 2 g once daily. Severe infection: 4 g daily at Hypersensitivity to cephalosporins. Neonates
12 hour intervals. INFANT & CHILD, 3 weeks - 12 aged less than or 28 days if they require
years: 20 - 80 mg/kg body weight daily. CHILD with treatment with calcium-containing intravenous
Ceftriaxone 0.5 g Injection Rocephin Infections caused by susceptible organisms be used to reconstitute ceftriaxonevials or to further reactions, coagulation disorders, phlebitis, Ciclosporin, typhoid vaccine
body weight 50 kg or more: adult dose. NEONATE up solutions, including calcium-containing infusions
to 2 weeks: 20 - 50 mg/kg body weight daily, not to such as parenteral nutrition, because of the risk
exceed 50 mg/kg of precipitation of ceftriaxone-calcium
ADULT: 1 - 2 g once daily. Severe infection: 4 g daily at Hypersensitivity to cephalosporins. Neonates
12 hour intervals. INFANT & CHILD, 3 weeks - 12 aged less than or 28 days if they require
years: 20 - 80 mg/kg body weight daily. CHILD with treatment with calcium-containing intravenous
Ceftriaxone 1g Injection Rocephin Infections caused by susceptible organisms be used to reconstitute ceftriaxonevials or to further reactions, coagulation disorders, phlebitis, Ciclosporin, typhoid vaccine
body weight 50 kg or more: adult dose. NEONATE up solutions, including calcium-containing infusions
to 2 weeks: 20 - 50 mg/kg body weight daily, not to such as parenteral nutrition, because of the risk
exceed 50 mg/kg of precipitation of ceftriaxone-calcium
GI disturbances occasionally
Upper respiratory tract, GUT, skin & soft tissue ADULT: 250 mg twice daily ;UTI: 125 mg twice daily.
Cefuroxime Axetil 125 mg Tablet Zinnat Anaphylactic reaction to penicillins pseudomembraneous colitis, hypersensitivity Hypersensitivity to cephalosporins Aminoglycosides, typhoid vaccine
infections, urinary tract infection (UTI), pyelonephritis CHILD:125 mg twice daily. Maximum 250 mg/day
reactions, eosinophilia, headache, superinfection
Cefuroxime Axetil 125 mg/5 ml
Zinnat Infections caused by susceptible organisms 30 mg/kg/day in 2 divided doses Anaphylactic reaction to penicillins pseudomembraneous colitis, hypersensitivity Hypersensitivity to cephalosporins Aminoglycosides, typhoid vaccine
Suspension
Upper respiratory tract, GUT, skin & soft tissue ADULT: 250 mg twice daily ;UTI: 125 mg twice daily.
Cefuroxime Axetil 250 mg Tablet Zinnat Anaphylactic reaction to penicillins pseudomembraneous colitis, hypersensitivity Hypersensitivity to cephalosporins Aminoglycosides, typhoid vaccine
infections, urinary tract infection (UTI), pyelonephritis CHILD:125 mg twice daily. Maximum 250 mg/day
ADULT: 750 mg 6 - 8 hours IM or IV. Severe infections: Hypersensitivity, GI disturbances including
Infections caused by susceptible organisms, surgical 1.5 g three times to four times daily IV. CHILD: 30 - 100 Anaphylactic reaction to penicillins, concurrent pseudomembraneous colitis, haematological Probenecid, aminoglycosides, live typhoid
Cefuroxime Sodium 1.5 g Injection Zinacef Hypersensitivity to cephalosporins
prophylaxis mg/kg/day in 3 - 4 divided doses. Surgical prophylaxis: treatment with potent diuretics. Renal impairment changes, superinfection, transient pain at IM vaccine
1.5 g IV injection site, thrombophlebitis (IV injection)
Cefuroxime Sodium 250 mg Injection Zinacef Hypersensitivity to cephalosporins
Cefuroxime Sodium 750 mg Injection Zinacef Hypersensitivity to cephalosporins
i) ADULTS: 200 mg once daily. CHILD not
recommended ii) 100mg twice daily, increased if GI disorders, flatulence, insomnia, pharyngitis,
necessary to 200 mg 2 times daily; CHILD not sinusitis, dizziness, vertigo, hearing disturbance,
recommended iii) 400mg as a single dose on first day Hypertension, cardiac conditions, liver/renal photosensitivity, blood disorder, fluid retention, Hypersensitivity to celecoxib, allergic-type
Diuretics, anti-coagulants, sulphonylureas,
i) Osteoarthritis ii) Rheumatoid Arthritis iii) Acute pain followed by 200mg once daily on subsequent days iv) dysfunction, elderly, fluid retention, children, renal failure, hepatic impairment, Steven- reaction to sulphonamides, aspirin or other
Celecoxib 200 mg Capsule Celebrex captopril, phenytoin, digoxin, fluconazole, lithium,
iv) Ankylosing Spondylitis Initial, 200 mg once daily or 100 mg twice daily; if no asthmatic, coagulation defects, pregnancy (third Johnson syndrome, allergic reactions, chest nonsteroidal anti-inflammatory agents, ischaemic
antacids, aspirin, glucocorticoids, warfarin
effect after 6 weeks, may increase to max. 400 mg daily trimester) pain, oedema, hot flushes, flu-like symptoms. heart disease and stroke patient
in 1-2 divided doses. If no response following 2 weeks Gastric side effects are lesser with this drug as
of treatment with 400 mg/day, consider discontinuation compared to other NSAIDs.
and alternative treatment
i) ADULTS: 200 mg once daily. CHILD not
recommended ii) 100 mg twice daily, increased if Gastrointestinal disorders, flatulence, insomnia,
necessary to 200 mg 2 times daily; CHILD not pharyngitis, sinusitis, dizziness, vertigo, hearing
recommended iii) 400 mg as a single dose on first day Hypertension, cardiac conditions, liver/renal disturbance, photosensitivity, blood disorder, Hypersensitivity to celecoxib, allergic-type
Diuretics, anti-coagulants, sulphonylureas,
i) Osteoarthritis ii) Rheumatoid Arthritis iii) Acute pain followed by 200 mg once daily on subsequent days iv) dysfunction, elderly, fluid retention, children, fluid retention, renal failure, hepatic impairment, reaction to sulphonamides, aspirin or other
Celecoxib 400 mg Capsule Celebrex® captopril, phenytoin, digoxin, fluconazole, lithium,
iv) Ankylosing Spondylitis Initial, 200 mg once daily or 100 mg twice daily; if no asthmatic, coagulation defects, pregnancy (third Steven-Johnson syndrome, allergic reactions, nonsteroidal anti-inflammatory agents, ischaemic
antacids, aspirin, glucocorticoids, warfarin
effect after 6 weeks, may increase to max. 400 mg daily trimester) chest pain, oedema, hot flushes, flu-like heart disease and stroke patient
in 1-2 divided doses. If no response following 2 weeks symptoms. Gastric side effects are lesser with
of treatment with 400 mg/day, consider discontinuation this drug as compared to other NSAIDs
and alternative treatment
Concurrent treatment with high doses of
Respiratory tract infections, ear, nose and throat GI disturbances, overgrowth of non-susceptible cephalosporins& aminoglycosides or potent
Cephalexin Monohydrate 125 mg/5 ml CHILD: 25 - 100 mg/kg/day every 6 hourly. Maximum: 4 Hypersensitivity to penicillins, renal impairment,
Ceporex infections, urinary tract infections, obstetric and organisms, hypersensitivity reactions, reversible Hypersensitivity to cephalosporins diuretics may adversely affect renal function.
Syrup g daily superinfection
gynaecologic infections neutropenia Probenecid may increase or prolong plasma
level& toxicity of cephalosporins
i) Respiratory tract infection, urinary tract infection ii) GI disturbances, overgrowth of non-susceptible cephalosporins& aminoglycosides or potent
Cephalexin Monohydrate 250 mg i) 250 mg 6 hourly ii) 250 - 500 mg 6 hourly iii) 1 - 1.5 g Hypersensitivity to penicillins, renal impairment,
Ceporex Complicated, recurrent or chronic infections, bronchitis organisms, hypersensitivity reactions, reversible Hypersensitivity to cephalosporins diuretics may adversely affect renal function.
Capsule 3 times daily or 4 times daily. Maximum: 6 g/day superinfection
iii) Pneumonia neutropenia Probenecid may increase or prolong plasma
i) Respiratory tract infection, urinary tract infection ii) GI disturbances; overgrowth of non-susceptible cephalosporins& aminoglycosides or potent
Cephalexin Monohydrate 250 mg ADULT: i) 250 mg 6 hourly ii) 250 - 500 mg 6 hourly iii) Hypersensitivity to penicillins, renal impairment,
Ceporex Complicated, recurrent or chronic infections, bronchitis organisms; hypersensitivity reactions, reversible Hypersensitivity to cephalosporins diuretics may adversely affect renal function.
Tablet 1 - 1.5 g 3 - 4 times daily. Maximum: 6 g/day superinfection
Respiratory tract infections, ear, nose and throat GI disturbances, overgrowth of non-susceptible cephalosporins& aminoglycosides or potent
Cephalexin Monohydrate 250 mg/5 ml CHILD: 25 - 100 mg/kg/day every 6 hourly. Maximum: 4 Hypersensitivity to penicillins, renal impairment,
Ceporex infections, urinary tract infections, obstetric and organisms, hypersensitivity reactions, reversible Hypersensitivity to cephalosporins diuretics may adversely affect renal function.
Syrup g daily superinfection
gynaecologic infections neutropenia Probenecid may increase or prolong plasma
i) Respiratory tract infection, urinary tract infection ii) GI disturbances, overgrowth of non-susceptible cephalosporins& aminoglycosides or potent
Cephalexin Monohydrate 500 mg i) 250 mg 6 hourly ii) 250 - 500 mg 6 hourly iii) 1 - 1.5 g Hypersensitivity to penicillins, renal impairment,
Ceporex Complicated, recurrent or chronic infections, bronchitis organisms, hypersensitivity reactions, reversible Hypersensitivity to cephalosporins diuretics may adversely affect renal function.
Capsule 3 times daily or 4 times daily. Maximum: 6 g/day superinfection
i) Respiratory tract infection, urinary tract infection ii) GI disturbances; overgrowth of non-susceptible cephalosporins& aminoglycosides or potent
Cephalexin Monohydrate 500 mg ADULT: i) 250 mg 6 hourly ii) 250 - 500 mg 6 hourly iii) Hypersensitivity to penicillins, renal impairment,
Ceporex Complicated, recurrent or chronic infections, bronchitis organisms; hypersensitivity reactions, reversible Hypersensitivity to cephalosporins diuretics may adversely affect renal function.
Tablet 1 - 1.5 g 3 - 4 times daily. Maximum: 6 g/day superinfection
Activities requiring mental alertness. Concurrent use
ADULT and CHILD over 6 years:10 mg daily or 5 mg Decreased cetirizine clearance resulting in
Urticaria, allergic dermatoses (insect bites, atopic of central nervous system depressants. Renal
Cetirizine HCl 10 mg Tablet Zyrtec twice daily. Child 2-6 years: 5 mg once daily or 2.5 mg Somnolence, fatigue, headache and dry mouth Hypersensitivity to cetirizine or hydroxyzine elevated cetirizine serum concentrations and
eczema), perennial rhinitis, allergic rhinitis insufficiency or hepatic dysfunction, elderly. Patient
twice daily possibly cetirizine toxicity with theophylline
less than 2 years
Contact with the eyes, brain, meninges, and middle
Hypersensitivity to cetrimide after prolonged and
Cetrimide 0.5% Cream Cetavlon As shampoo and cleanser Apply to affected area ear should be avoided. Cetrimide should not be used Hypersensitivity to cetrimide Not known
repeated applications
in body cavities or as an enema
Contact with the eyes, brain, meninges, and middle
Cetrimide 1-2% Lotion. Cetavlon As shampoo and cleansing agent Apply to affected area ear should be avoided. Cetrimide should not be used Cutaneous irritation and local effects Hypersensitivity to cetrimide Not known
in body cavities or as an enema
Prevention of premature ovulation in patients Given by SC 0.25 mg/day, given either in the morning
Active allergic conditions or a history of allergies, Mild and transient injection site reaction, nausea, Pregnancy and lactation, moderate to severe
undergoing a controlled ovarian stimulation, followed beginning on the day 5 or 6 of ovarian stimulation or in
Cetrorelix 0.25 mg Injection Cetrotide children. Not intended for use in elderly more than headache, ovarian hyperstimulation syndrome, renal or hepatic impairment, severe allergic Not known
by oocyte pick-up and assisted reproductive the evening beginning on day 5, and continued until
65 years rarely hypersensitivity reactions condition
techniques ovulation induction
i) ADULT 0.5-1 g given 3-4 times daily. CHILD half

adult dose. ii) Need to be dissolved in liquid (slurry
Acarbose, carbamazepine, digoxin, frusemide,
consistency). ADULT and CHILD over 12 years: initial
olanzapine, phenytoin; decreased effectiveness
30-100 g or 1-2 g/kg; repeat initial dose as soon as
i) Diarrhoea and food poisoning ii) Reduce absorption Aspiration of charcoal, hydrocarbons, corrosive, of these drugs, reduce absorption of oral therapy
possible or 20-50 g every 2-6 hours. CHILD over 1-12 An unprotected airway, gastrointestinal tract not
Charcoal, Activated 250 mg Tablet - of drugs, plant, inorganic poison and chemicals in imaging of gastroesophageal. Caution in patient at Black stools and gastrointestinal disturbances and render their effectiveness, simultaneous oral
years, 25-50 g or 1-2 g/kg; may repeat half the initial anatomically intact
poisoning cases risk of gastrointestinal obstruction therapy should be avoided. Clear activated
dose every 2-6 hour as needed. CHILD to 1 year of
charcoal from stomach /avoid its usage if
age, 1 g/kg; may repeat half the initial dose every 2-6
methionine (specific oral antidote) is to be used
hours as needed. For maximum efficacy administer
within 1 hour after ingestion of toxic compound
History of gastritis or duodenal ulcers, mentally Arrhythmias, hallucination, disorientation,
Warfarin, increased risk of bleeding. Frusemide,
depressed patients, severe cardiac disease, nausea, vomiting, diarrhoea, gastric irritation, Hypersensitivity to chloral hydrate products,
ADULT : 0.5 - 1 g (max 2 g) with plenty of water at cardiovascular toxicity (diaphoresis,
Chloral Hydrate 200 mg/5 ml Mixture - Preoperative sedation respiratory disease, lactation, acute intermitent vertigo, nightmares, delirium, flatulence, cardiac disease, hepatic or renal impairment,
bedtime. CHILD : 30 - 50 mg/kg up to a max dose of 1 g hypertension, tachycardia). Alcohol, increased
porphyria, skin/mucous membrane irritation, avoid abdominal distention, leucopenia, eosinophilia, pregnancy, breast feeding, porphyria, gastritis
sedation. May reduce effect of phenytoin
prolonged use and abrupt withdrawal ketonuria, respiratory depression, rashes
Myelosuppression, azoospermia/amenorrhoea,
Myelosuppression. Monitor blood counts. History of
rash, allergic reactions, seizures, nausea and
seizures. If generalised skin rash develops during
Low grade lymphoma, chronic lymphocytic leukaemia. vomiting, diarrhoea, stomatitis, interstitial Ciclosporin, phenobarbital, phenytoin,
Chlorambucil 2 mg Tablet Leukeran 200 mcg/kg body weight daily for 4 - 8 weeks treatment, to stop therapy to avoid progressing to Hypersensitivity to chlorambucil, pregnancy
Ovarian cancer pneumonitis, pulmonary fibrosis, transient allopurinol, live vaccines
erythema multiforme, toxic epidermal necrolysis or
elevation of liver enzymes, secondary
Stevens-Johnson syndrome
malignancies
Overgrowth of non-susceptible organisms in Allergic reactions, superinfection, bone marrow
Chloramphenicol 0.5% Eye Drops Chloromycetin Broad spectrum antibiotic in superficial eye infections 1 - 2 drops every 3 - 4 hours Hypersensitivity to chloramphenicol products Not known
prolonged use hypoplasia including aplastic anaemia
Apply 1/2 inch of ointment every 3 - 4 times into the Overgrowth of non-susceptible organisms in Allergic reactions, superinfection, bone marrow
Chloramphenicol 1% Eye Ointment Chloromycetin Conjunctivitis and other superficial eye infection Hypersensitivity to chloramphenicol products Not known
conjunctival sac prolonged use hypoplasia including aplastic anaemia
CHILD: 25 - 50 mg/kg/day in 4 divided doses. Severe Aplastic anaemia. Haemolytic anaemia in G6PD
Avoid prolong treatment or use in minor infections.
Chloramphenicol 125 mg/5 ml Typhoid fever, salmonella infections, meningitis, infections, premature& full-term infants less than 2 deficiency. Grey syndrome, bleeding, Bone marrow depressants, enhance effects of
Chloromycetin Liver impairment. Uraemic patients, infants, Hypersensitivity to chloramphenicol
Suspension cholera, anaerobic and rickettsial infections weeks: 25mg/kg/day in divided doses. Full-term infants peripheral& optic neuritis, hypersensitivity coumarin anticoagulants& warfarin, phenytoin
pregnancy, active immunisation
more than 2 weeks: up to 50mg/kg/day in divided doses reaction& erythema multiforme
Aplastic anaemia. Haemolytic anaemia in G6PD
ADULT: 500 mg 4 times daily or 50 mg/kg/day in 4 Avoid prolong treatment or use in minor infections. Bone marrow depressants, enhance effects of
Treatment of typhoid, paratyphoid fevers, deficiency. Grey syndrome, bleeding, peripheral
Chloramphenicol 250 mg Capsule Chloromycetin divided doses. Maximum dose: 4 g/day. CHILD: 25 - Liver impairment. Uraemic patients, infants, Hypersensitivity to chloramphenicol coumarin anticoagulants & warfarin, phenytoin &
bronchopneumonia and enteric infection & optic neuritis, hypersensitivity reaction&
100 mg/kg/day in 4 divided doses pregnancy, active immunisation some hypoglycaemic agents
erythema multiforme
Use with caution in the presence of perforated Sensitivity to the vehicle propylene glycol, local Hypersensitivity to chloramphenicol products,
Apply 2 - 3 drops into the ear 2 - 3 times daily. Not to be With other antibacterials, antiepileptics,
Chloramphenicol 5% w/v Ear Drops Chloromycetin Acute otitis media, otitis externa with perforation tymphanic membrane. Overgrowth of non- irritation with symptoms of burning, itching, perforated tympanic membrane, chronic otitis
used for long term anticoagulants, cyclosporin
susceptible infection over prolonged use urticaria, transient stinging media with perforation
Depression of bone marrow leading to Phenobarbitone& rifampicin may reduce the
ADULT: 1.5 - 3 g daily in divided doses every 6 hourly. Repeated courses& chronic treatment, infants, agranulocytosis, thrombocytopenia purpura, plasma concentration. Drugs which potentially
Chloramphenicol Sodium Succinate 1 Treatment of typhoid, paratyphoid fevers, Hypersensitivity, pregnancy and lactation,
Chloromycetin CHILD: 25 -100 mg/kg/day in divided doses every 6 impaired liver or kidney function. Frequent leucopenia and aplastic anaemia. Peripheral& depress bone marrow function. May potentiate
g Injection bronchopneumonia and enteric infection anaemia, porphyria
hourly haematological examination is recommended optic neuritis, erythema multiforme, GI disorders, actions of phenytoin, sulfonylureas&
urticaria, dry mouth and blurred vision anticoagulants
Avoid prolonged skin contact with alcoholic solution. Patients who have previously shown a
Chlorhexidine Gluconate 0.2 % Occasionally, irritative skin reactions, extremely
Hibitane As a gargle Rinse mouth with 10 ml for about 1 minute twice daily Avoid contact with eyes, brain, meninges, middle ear hypersensitivity reaction to chlorhexidine. Not known
Mouthwash rare, generalised allergic reactions
and body cavities. For external use only However, such reaction are extremely rare
Surgical hand disinfection: Apply 5ml to clean hands

Occasionally irritative skin reactions, generalised
and forearms for 1 min. Rinse and repeat with another
Surgical hand scrub/disinfection, pre-op skin For external use only. Avoid contact with eyes and allergic reactions, may cause gastrointestinal Hypersensitivity to chlorhexidine gluconate or
Chlorhexidine Gluconate 4% Scrub Hibiscrub 5ml for a further 2 mins and then rinse and dry. General Not known
preparation middle ear disturbances. Inhalation of solvent vapours may any component of the formulation
skin disinfection: Apply appropriate quantity to wet area
give rise to nausea, headaches and dizziness
and scrub for 1 min. Rinse thoroughly & dry
Mucosal irritation (discontinue if desquamation),
Avoid contact with meninges, application into hairy
parotid gland swelling, irritation and
i) Preoperative skin disinfection ii) Wounds or burns iii) areas and not use as a preoperative skin
Chlorhexidine Gluconate 5% Solution Hibitane i) & iii) 1 : 10 in 70 % Alcohol ii) 1 : 100 gastrointestinal disturbances. Inhalation of Hypersensitivity to any of its components Avoid cemented glass components
Emergency disinfection of instruments preparation for the face or head. Keep disinfectant
solvent vapours may give rise to nausea,
solution out of the eyes, ears and mouth
headaches and dizziness
Pre-op surgical hand disinfection: Spread 5ml throughly
over both hands and forearms, rubbing vigorously.
Incompatible with soaps and other anionic
When dry apply a further 5ml and repeat procedure. Avoid contact with eyes, brain meninges, body
Chlorhexidine Gluconate 5% Solution Occasionally irritative skin reactions, rare agents. Hypochlorite bleaches may cause brown
Antiseptic hand disinfection on the ward: Spread 3ml cavities, middle ear. Not for injection. Avoid Hypersensitivity to chlorhexidine gluconate or
1:10 in 70% alcohol with lanolin as Hibisol To be used undiluted for hand and skin disinfections generalised allergic reactions, dizziness, stains to develop in fabrics which have
throughly over the hands and wrist rubbing vigorously prolonged skin contact. Allow to dry before any component of the formulation
emollient confusion, headache or stupor previously been in contact with chlorhexidine
until dry. Disinfection of patient's skin: Prior to surgery, proceeding
solutions
apply to a sterile swab and rub thoroughly over the
operation site for a minimum of 2 mins
Irritating to skin, dissolves blood clots, delay
Chlorinated Lime Powder - Antiseptic and disinfectants Not applicable Bleaches fabric, irritant, do not use on open wounds Not known No interaction found
clotting
Chlorinated Lime Solution & Buffered Topically applied hypochlorites may dissolve blood Patients who have previously shown a
Eusol-T Wound or ulcer Apply to affected areas undiluted as a cleansing agent Skin irritation Not known
Acetate Solution clots and cause bleeding hypersensitivity reaction
ADULT 600 mg base stat, 300 mg 6 - 8 hours later and

a further 300 mg on each of 2 following days. CHILD 3 - May exacerbate psoriasis or trigger an acute attack Simultaneous use of corticosteroids can
Chloroquine Phosphate 250 mg Loss of appetite, nausea, pressure over the G6PD deficiency, diseases of haematopoietic
- Treatment of malaria - acute attack 4 years : 150 mg base stat, 75 mg 6 hours later, then of hepatic porphyria (metabolic abnormality). Pre- accentuate possible myopathies and
Tablet (150 mg Chloroquine base) stomach, visual disturbances organs or CNS, retinopathy
75 mg daily for 2 days. CHILD 5 - 8 years : 300 mg stat, existing kidney damage, first trimester of pregnancy cardiomyopathies
150 mg 6 hours later, then 150 mg daily for 2 days
Porphyria, pregnancy, asthma, glaucoma, avoid Drowsiness, dizziness, stinging or burning
10 - 20 mg IM or SC, repeated if required. Not to
Chlorpheniramine Maleate 10 mg/ml operating vehicles or machinery. Parenteral injection sensation at injection site, hypotension, CNS Alcohol pontentiate CNS depressants, actions
Piriton Allergic conditions exceed 40 mg in 24 hours. 10 - 20 mg over 1 minute by Hypersensitivity to chlorpheniramine
Injection have to be protected from light to prevent stimulation, tinnitus, blurred vision, irritability, prolonged by MOAIs, anticholigernic drugs
slow IV
discolouration lassitude
CHILD 1 - 2 years : 1 mg twice daily, 2 - 5 years : 1 mg Drowiness, dizziness, hypotension, CNS
Chlorpheniramine Maleate 2 mg/5 ml Symptomatic treatment of allergic conditions Porphyria, pregnancy, asthma, glaucoma, avoid Alcohol pontentiate CNS depressants, actions
Piriton every 4 - 6 hours (maximum 6 mg daily), 6 - 12 years : stimulation, tinnitus, blurred vision, irritability, Hypersensitivity to chlorpheniramine
Syrup responsive to antihistamine operating vehicles or machinery prolonged by MAOIs, anticholigernic drugs
2 mg every 4 - 6 hours (maximum 12 mg daily) lassitude
ADULT : 4 mg every 4 - 6 hours. Maximum 24 mg daily.

Drowsiness, dizziness, hypotension, CNS
Chlorpheniramine Maleate 4 mg Symptomatic treatment of allergic conditions CHILD 1 - 2 years : 1 mg twice daily, 2 - 5 years : 1 mg Prophyria, pregnancy, asthma, glaucoma avoid Alcohol, CNS depressants, MAOIs,
Piriton stimulation, tinnitus, blurred vision, irritability, Hypersensitivity to chlorpheniramine
Tablet responsive to antihistamines every 4 - 6 hours (maximum 6 mg daily), 6 - 12 years : operating vehicles or machinery anticholinergics drugs
lassitude
2 mg every 4 - 6 hours (maximum 12 mg daily)
Postural hypotension, akathisia, tardive

dyskinesia, arrhythmias, constipation, Alcohol, CNS depressant, anticholinergic,
Pregnancy and lactation, elderly, epilepsy or history
haematologic effects, agranulocytosis, aplastic tramadol, phenobarbitone, beta-blockers
of seizure, impaired kidney and liver function,
anaemia, thrombocytopenia, neuroleptic (metoprolol, atenolol, propranolol),
ADULT : Initial dose - 25 mg 3 times daily according to Parkinson's disease, severe hypotension,
malignant syndrome, jaundice, agitation, Hypersensitivity to chlorpromazine products, captopril,norepinephrine, procyclidine, warfarin,
response up to 1 g daily. PAEDIATRIC: Up to 5 years: hypothyroidism, cardiac failure,
insomnia, parkinsonism symptoms, drowsiness, phenothiazines, myelosuppression, coma, epinephrine, cimetidine, ethanol, adrenaline,
Chlorpromazine HCl 100 mg Tablet Largactil Psychosis mania and agitation 0.5 mg/kg body weight every 4 - 6 hours (Maximum 40 phaeochromocytoma, myasthenia gravis & prostate
convulsion and tachycardia, acute dystonia, severe CNS depression, bone marrow antacids, amphetamine, amiodarone,
mg daily). CHILD 6 - 12 years: A third to half adult dose hypertrophy. Avoid in patient hypersensitive to
leukopenia, angioedema, bronchospasm, depression bumetamide, chlorothiazides, clarithromycin,
(Maximum 75 mg daily) phenothiazines, history of narrow-angle glaucoma or
urticaria, hyperprolactinemia, eye, cardiac, skin erythromycin, frusemide, phenytoin,
agranulocytosis. Monitor BP & complete blood count.
& subcutanoues tissue disorders, dry mouth, antiarrhythmics, antidepressants & other
Avoid exposure to sunlight
respiratory depression, neuroleptic malignant antipsychotics, carbamazepine
syndrome. Rarely agranulocytosis, priapism
Postural hypotension, akathisia, tardive
dyskinesia, arrhythmias, constipation, Alcohol, CNS depressant, anticholinergic,
Pregnancy and lactation, elderly, epilepsy or history
haematologic effects, agranulocytosis, aplastic tramadol, phenobarbitone, beta-blockers
of seizure, impaired kidney and liver function,
anaemia, thrombocytopenia, neuroleptic (metoprolol, atenolol, propranolol),
ADULT : Initial dose - 25 mg 3 times daily according to Parkinson's disease, severe hypotension,
malignant syndrome, jaundice, agitation, Hypersensitivity to chlorpromazine products, captopril,norepinephrine, procyclidine, warfarin,
response up to 1 g daily. PAEDIATRIC: Up to 5 years: hypothyroidism, cardiac failure,
insomnia, parkinsonism symptoms, drowsiness, phenothiazines, myelosuppression, coma, epinephrine, cimetidine, ethanol, adrenaline,
Chlorpromazine HCl 25 mg Tablet Largactil Psychosis mania and agitation 0.5 mg/kg body weight every 4 - 6 hours (Maximum 40 phaeochromocytoma, myasthenia gravis & prostate
convulsion and tachycardia, acute dystonia, severe CNS depression, bone marrow antacids, amphetamine, amiodarone,
mg daily). CHILD 6 - 12 years: A third to half adult dose hypertrophy. Avoid in patient hypersensitive to
leukopenia, angioedema, bronchospasm, depression bumetamide, chlorothiazides, clarithromycin,
(Maximum 75 mg daily) phenothiazines, history of narrow-angle glaucoma or
urticaria, hyperprolactinemia, eye, cardiac, skin erythromycin, frusemide, phenytoin,
agranulocytosis. Monitor BP & complete blood count.
& subcutanoues tissue disorders, dry mouth, antiarrhythmics, antidepressants & other
Avoid exposure to sunlight
respiratory depression, neuroleptic malignant antipsychotics, carbamazepine
syndrome. Rarely agranulocytosis, priapism
Hypersensitivity to chlortetracycline or to any
Chlortetracycline 1% Eye Ointment - Eye infections require a broad spectrum antibiotic Instill 1/2 inch 2 - 3 times daily Overgrowth of non-susceptible organisms Allergic reaction (occasional) Ciclosporin
agents in the tetracycline class
Apply directly to affected area twice daily as required Erythema, maculopapular lesions and Hypersensitivity to chlortetracycline or to any
Chlortetracycline 1-3 % Cream - Bacterial skin infections Photosensitivity Not known
for 1 - 2 weeks phototoxicity agents in the tetracycline class
Prophylactic ADULT: First dose of 0.5 ml SC/IM
Tachycardia and hypotension, neurologic
followed after 1 - 4 weeks by a second dose of 1 ml. Infants less than 6 months of age. Revaccination
Avoid administration to immunosuppressed patients, disorders, anaphylaxis and hypersensitivity
Cholera Vaccine - Immunisation of cholera CHILD: 1 - 5 years: 0.1 ml (1st dose), 0.3 ml (2nd is not advisable if serious reaction to the vaccine Yellow fever vaccine
use in pregnant women only when necessary reactions, malaise, low-grade-fever, generalized
dose). CHILD; 5 - 10 years: 0.3 ml (1st dose), 0.5ml has occurred
aches and pains, urticaria
(2nd dose)
Amiodarone, cephalexin, chlorothiazide,
Increased bleeding tendency may develop due to
i) Hypercholesterolemia ii) Pruritus of skin associated diclofenac, digitoxin, digoxin, entacapone,
Hypercholesterolemia: Adjunct: initial, 4 g orally 1-2 hypoprothrombinaemia from vitamin K deficiency, Abdominal discomfort, bleeding tendencies due Complete biliary obstruction, hyperlipidaemia
with partial biliary obstruction iii) Diarrhoea due to bile frusemide, hydrochlorothiazide, leflunomide,
Cholestyramine Resin 4 G Questran light times daily, maintenance, 8 to 16 g in divided doses, may interfere with fat absorption, absorption of fat to hypoprothrombinaemia, constipation, type III, IV or V. Hypersensitivity to bile-
acid malabsorption iv)Familial hypercholesterolemia - meloxicam, methotrexate, metronidazole,
max 24 g daily CHILD: 50 - 150 mg/ kg 6 - 8 hourly oral soluble vitamins may be decreased and pre-existing flatulence, nausea and vomiting sequestering resins
heterozygous v) Generalized atherosclerosis mycophenolate mofetil, pravastatin, raloxifene,
constipations
valproic acid, warfarin
Infants less than 4 months or in patients with a
Excessive use can lead to salicylate poisoning.
history of salicylate sensitivity. Preparations
Choline Salicylate 8.7%, Cetylkonium For relief of the pain and discomfort in mouth ulcers During therapy, do not give aspirin to children 16
Bonjela Apply to area 4 times daily Not known containing aspirin should not be given to young Not known
Chloride 0.01% Dental Gel and sores, infant teething and denture irritation year. Co-administration with drugs for blood clots
children during treatment to avoid any risk of
and gout. Stomach ulcer. Pregnancy
excessive salicylate levels
When used with gonadotrophins (Follicle
Induction of ovulation: 5000 - 10,000 units one day Thromboembolism, oedema, headache,
Treatment of infertile women to induce ovulation and as Use of human gonadotrophin either to induce Androgen dependent neoplasia prior allergic Stimulating Hormone), ovarian hyperstimulation
Chorionic Gonadotrophin Human following last dose of menotropin. Up to 3 repeat irritability, restlessness, depression and
Pregnyl a luteal support in controlled ovarian hyperstimulation ovulation or as a luteal support, may increase the reaction to chorionic gonadotrophin, active syndrome, enlargement of ovarian cysts or
(HCG) 5000 IU Injection injections of 5000 units each may be given within the tiredness, salt and fluid retention, pain at
cycles risk of ovarian hyperstimulation syndrome (OHSS) thrombophlebitis rupture of ovarian cysts and multiple births may
following 9 days to prevent insufficiency corpus luteum injection site, skin rashes
occur
ADULT and ADOLESCENT above 18 years : 80 - 320 Active or quiescent pulmonary tuberculosis,
Cataracts, corticosteroid withdrawal, cross-
mcg/day administered as 1 or 2 puffs. Recommended Headache, otalgia, epistaxis, nasopharyngitis, fungal, bacterial or viral infections of the
hypersensitivity reactions, history of intraocular
Prophylactic treatment of asthma in adults and starting dose : 80 mcg once daily for patients previously paradoxical bronchospasm, oropharyngeal respiratory system. Not indicated for status Caution when co-administered with potent
Ciclesonide 160mcg Inhalation Alvesco pressure changes, immunosuppressed patients,
adolescents 12 years of age and older maintained on bronchodilators alone. Patient candidiasis, voice hoarseness, bruising, asthmaticus or other acute episodes of asthma. CYP3A4 inhibitors eg ketoconazole, ritonavir
infection, pediatric patients, periods of stress, recent
maintained on another inhaled corticosteroid may cataracts, glaucoma and osteoporosis Not for relief of acute asthma symptoms. Should
nasal surgery, nasal septum ulcers, or nasal trauma
require a higher dose not be stopped abruptly. Pregnancy, lactation
i & ii) Initially 12.5 - 15 mg/kg/day, beginning on the day
before transplant. Maintenance approx 12.5 mg/kg/day
for 3 - 6 months before being tapered off to zero by 1 Etoposide, statins, vaccines,
Only for: i) Patients in whom donor specific Hypersensitivity to ciclosporin or any other
year of transplantation iii) 3 mg/kg/day in 2 divided immunosuppressive drugs except
transplantation cannot be carried out and in young component, rheumatoid arthritis or psoriasis
doses for first 6 weeks. May increased gradually to History of allergic reactions, pregnancy, monitor BP, corticosteroids, live vaccines, nephrotoxic drugs,
children to minimise side-effects of steroids ii) Follow- Nephrotoxicity, hepatotoxicity, gum hyperplasia, patients with abnormal renal function,
maximum 5 mg/kg. Treatment withdrawn if no response serum electrolytes, renal and hepatic function, NSAIDs, hepatic enzyme inducers. Increased
up cases of bone marrow transplant iii) Patients with hypertension, neurotoxicity, convulsions, uncontrolled hypertension, malignancies,
after 3 months iv) ADULT: 5 mg/kg/day in 2 divided hypertension & malignancies. Neoral and ciclosporin level by diltiazem, doxycycline,
severe rheumatoid arthritis not responding to other increased malignancy risk, tremor, paraesthesia, uncontrolled infections in rheumatoid arthritis
Ciclosporin 100 mg Capsule doses. CHILD: 6 mg/kg/day in 2 divided doses. Patients Sandimmun are not bioequivalent - dosage erythromycin, ketoconazole, nicardipine,
Sandimmun Neoral second line drugs iv) Patients with idiopathic nephrotic hypertrichosis, facial oedema, acne, gingival patients, primary or secondary immunodeficiency
Microemulsion with permitted levels of kidney failure, the starting dose adjustments and increased monitoring needed. verapamil, oral contraceptives. Drugs which
syndrome who are steroid toxic or poor response to hypertrophy, hyperkalaemia, fluid retention, in rheumatoid arthritis patients, psoriasis patients
must not more than 2.5 mg/kg/day v) 12 mg/kg/day. vi) Increased risk for opportunistic infections such as reduce ciclosporin level are carbamazepine,
cyclophosphamide v) Severe aplastic anemia, pure red increased susceptibility to infections, receiving PUVA (psoralen plus ultraviolet A) or
2.5 mg/kg/day in 2 divided doses increasing if there is activation of latent viral infections including BK virus - isoniazid, phenobarbitone, phenytoin and
cell aplasia vi) Cases of recalcitrant psoriasis and gastrointestinal symptoms UVB (ultraviolet B) therapy, methotrexate or
no improvement after 4 weeks by 0.5 -1 mg/kg/month associated nephropathy rifampicin. Increased risk of convulsion when
atopic eczema vii) Treatment of chronic ocular other immunosuppressants, coal tar, radiation
up to maximum 5 mg/kg/day vii) 5 mg/kg/day in 2 used concurrently with high-dose
inflammatory disorders/uveitis therapy & lactation
divided doses, may increase to 7 mg/kg/day in resistant methylprednisolone
cases. Maintenance: Less than 5 mg/kg/day especially
during remission
before transplant. Maintenance approx 12.5 mg/kg/day Hypersensitivity to ciclosporin, or any other Etoposide, statins,vaccines, immunosuppressive
Only for : i) Patients in whom donor specific
for 3 - 6 months before being tapered off to zero by 1 component. Rheumatoid arthritis or psoriasis drugs except corticosteroids, live vaccines,
transplantation cannot be carried out and in young History of allergic reactions, pregnancy; monitor BP,
year of transplantation iii) 3 mg/kg/day in 2 divided Nephrotoxicity, hepatotoxicity, gum hyperplasia, patients with abnormal renal function, nephrotoxic drugs, NSAIDs, hepatic enzyme
children to minimise side-effects of steroids ii) Follow- serum electrolytes, renal and hepatic function,
doses for first 6 weeks. May increased gradually to hypertension, neurotoxicity, convulsions, uncontrolled hypertension, malignancies, inducers. Increased ciclosporin level by
up cases of bone marrow transplant iii) Patients with hypertension & malignancies. Neoral and
maximum 5 mg/kg. Treatment withdrawn if no response increased malignancy risk, tremor, paraesthesia, uncontrolled infections in rheumatoid arthritis diltiazem, doxycycline, erythromycin,
severe Rheumatoid arthritis not responding to other Sandimmun are not bioequivalent - dosage
Ciclosporin 100 mg/ml Drink Solution Sandimmum Neoral after 3 months iv) ADULT: 5 mg/kg/day in 2 divided hypertrichosis, facial oedema, acne, gingival patients, primary or secondary immunodeficiency ketoconazole, nicardipine, verapamil, oral
second line drugs iv) Patients with idiopathic nephrotic adjustments and increased monitoring needed.
doses. CHILD: 6 mg/kg/day in 2 divided doses. Patients hypertrophy; hyperkalaemia, fluid retention, in rheumatoid arthritis patients, psoriasis patients contraceptives. Drugs which reduce ciclosporin
syndrome who are steroid toxic or poor response to Increased risk for opportunistic infections such as
with permitted levels of kidney failure, the starting dose increased susceptibility to infections, receiving PUVA (psoralen plus ultraviolet A) or level are carbamazepine, isoniazid,
cyclophosphamide v) Severe aplastic anaemia, pure activation of latent viral infections including BK virus -
must not more than 2.5 mg/kg/day v) 12 mg/kg/day vi) gastrointestinal symptoms UVB (ultraviolet B) therapy, methotrexate or phenobarbitone, phenytoin and rifampicin.
red cell aplasia vi) Cases of recalcitrant psoriasis and associated nephropathy
2.5 mg/kg/day in 2 divided doses increasing if there is other immunosuppressants, coal tar, radiation Increased risk of convulsion when used
atopic eczema
no improvement after 4 weeks by 0.5 -1 mg/kg/month therapy, lactation concurrently with high-dose methylprednisolone
up to maximum 5 mg/kg/day
before transplant. Maintenance approx 12.5 mg/kg/day
for 3 - 6 months before being tapered off to zero by 1 Etoposide, statins, vaccines,
Only for: i) Patients in whom donor specific Hypersensitivity to ciclosporin or any other
year of transplantation iii) 3 mg/kg/day in 2 divided immunosuppressive drugs except
transplantation cannot be carried out and in young component, rheumatoid arthritis or psoriasis
doses for first 6 weeks. May increased gradually to History of allergic reactions, pregnancy, monitor BP, corticosteroids, live vaccines, nephrotoxic drugs,
children to minimise side-effects of steroids ii) Follow- Nephrotoxicity, hepatotoxicity, gum hyperplasia, patients with abnormal renal function,
maximum 5 mg/kg. Treatment withdrawn if no response serum electrolytes, renal and hepatic function, NSAIDs, hepatic enzyme inducers. Increased
up cases of bone marrow transplant iii) Patients with hypertension, neurotoxicity, convulsions, uncontrolled hypertension, malignancies,
after 3 months iv) ADULT: 5 mg/kg/day in 2 divided hypertension & malignancies. Neoral and ciclosporin level by diltiazem, doxycycline,
severe rheumatoid arthritis not responding to other increased malignancy risk, tremor, paraesthesia, uncontrolled infections in rheumatoid arthritis
Ciclosporin 25 mg Capsule doses. CHILD: 6 mg/kg/day in 2 divided doses. Patients Sandimmun are not bioequivalent - dosage erythromycin, ketoconazole, nicardipine,
Sandimmun Neoral second line drugs iv) Patients with idiopathic nephrotic hypertrichosis, facial oedema, acne, gingival patients, primary or secondary immunodeficiency
Microemulsion with permitted levels of kidney failure, the starting dose adjustments and increased monitoring needed. verapamil, oral contraceptives. Drugs which
syndrome who are steroid toxic or poor response to hypertrophy, hyperkalaemia, fluid retention, in rheumatoid arthritis patients, psoriasis patients
must not more than 2.5 mg/kg/day v) 12 mg/kg/day vi) Increased risk for opportunistic infections such as reduce ciclosporin level are carbamazepine,
cyclophosphamide v) Severe aplastic anemia, pure red increased susceptibility to infections, receiving PUVA (psoralen plus ultraviolet A) or
2.5 mg/kg/day in 2 divided doses increasing if there is activation of latent viral infections including BK virus - isoniazid, phenobarbitone, phenytoin and
cell aplasia vi) Cases of recalcitrant psoriasis and gastrointestinal symptoms UVB (ultraviolet B) therapy, methotrexate or
no improvement after 4 weeks by 0.5 -1 mg/kg/month associated nephropathy rifampicin. Increased risk of convulsion when
atopic eczema vii) Treatment of chronic ocular other immunosuppressants, coal tar, radiation
up to maximum 5 mg/kg/day vii) 5 mg/kg/day in 2 used concurrently with high-dose
inflammatory disorders/uveitis therapy & lactation
divided doses, may increase to 7 mg/kg/day in resistant methylprednisolone
cases. Maintenance: Less than 5 mg/kg/day especially
during remission
Hypersensitivity to ciclosporin, or any other
component. Rheumatoid arthritis or psoriasis
patients with abnormal renal function,
Liver and renal function, hypertension, malignancies.
uncontrolled hypertension, malignancies,
Neoral(R) and Sandimmun(R) are not bioequivalent - Etoposide, statins, vaccines,
Nephrotoxicity, hepatotoxicity, gum hyperplasia, uncontrolled infections in rheumatoid arthritis
i) Post bone marrow transplant ii) Solid organ i) 3 - 5 mg/kg/day until tolerate orally ii) 2 - 3 mg/kg/day dosage adjustments and increased monitoring immunosuppressive drugs except
Ciclosporin 50 mg/ml Injection Sandimmum hypertension, neurotoxicity, convulsions, patients, primary or secondary immunodeficiency
transplant for recipients who are unable to take orally needed. Increased risk for opportunistic infections corticosteroids, live vaccines, nephrotoxic drugs,
increased malignancy risk in rheumatoid arthritis patients, psoriasis patients
such as activation of latent viral infections including rifampicin, NSAIDs, hepatic enzyme inducers
receiving PUVA (psoralen plus ultraviolet A) or
BK virus -associated nephropathy
UVB (ultraviolet B) therapy, methotrexate or
other immunosuppressants, coal tar, radiation
therapy
Menstrual disorder, history of liver disease.
Pregnancy and lactation.Should stop taking the
product and consult doctor if signs and symptoms Bradycardia, dizziness, headache, tremors,
Cimicifuga Racemosa Rhizome Traditionally used for the relief of hot flushes, sweating, Hypersensitivity to black cohosh, lactation,
Remifemin 20 mg twice daily suggestive of liver injury developed such as giddiness, nausea, vomiting hepatotoxicity, skin Azathioprine, ciclosporine, tamoxifen
Extract 20 mg Tablet restlessness associated with menopause pregnancy
tiredness, loss of appetite, yellowing of the skin and rash, pruritus
eyes or severe upper stomach pain with nausea and
vomiting or dark urine
Gastrointestinal disturbances, epigastric pain,
Pregnancy, Parkinson's disease. May affect ability to
Cinnarizine 25 mg Tablet Stugeron Vestibular disorders One tablet 3 times daily nausea and vomiting, tinnitus, lupus Avoid in porphyria Alcohol, CNS depressants
drive or operate machinery
erythematosus
Nausea, diarrhoea, vomiting, dyspepsia,
abdominal pain, flatulence, anorexia, dizziness,
headache, tiredness, agitation, trembling,
Theophylline, iron, magnesium, aluminium,
ADULT uncomplicated infections:200 mg/day; acute insomnia, peripheral paralgesia, sweating,
Hypersensitivity to ciprofloxacin or other calcium, sulcralfate, antacids, probenecid,
Treatment of infections due to susceptible bacterial gonorrhoea and acute uncomplicated cystitis in women Epilepsy, CNS disorder, liver damage, renal unsteady gait, convulsions, increase in
Ciprofloxacin 100 mg/50 ml Injection Ciprobay quinolones. Children, adolescents, pregnancy NSAIDs, antineoplastics, immunosuppressants,
strains can be treated with a single infusion of 100 mg.Other impairment. Avoid prolonged exposure to sunlight intracranial pressure, anxiety states, nightmares,
and lactation cyclosporin, warfarin, glibenclamide,
infections: 400-800 mg/day confusion, depression, hallucinations, impaired
metoclopramide and other prokinetic drugs
taste and smell, visual disturbances, tinnitus,
transitory impairment of hearing, especially at
high frequencies, skin reactions
ADULT uncomplicated infections:200 mg/day; acute insomnia, peripheral paralgesia, sweating,
Treatment of infections due to susceptible bacterial gonorrhoea and acute uncomplicated cystitis in women Epilepsy, CNS disorder, liver damage, renal unsteady gait, convulsions, increase in
Ciprofloxacin 200 mg/100 ml Injection Ciprobay quinolones. Children, adolescents, pregnancy NSAIDs, antineoplastics, immunosuppressants,
strains can be treated with a single infusion of 100 mg.Other impairment. Avoid prolonged exposure to sunlight intracranial pressure, anxiety states, nightmares,
and lactation cyclosporin, warfarin, glibenclamide,
infections: 400-800 mg/day confusion, depression, hallucinations, impaired
taste and smell, visual disturbances, tinnitus,
insomnia, peripheral paralgesia, sweating,
Treatment of infections due to susceptible bacterial ADULT: 125-750 mg twice daily. Acute gonorrhoea: a Epilepsy, CNS disorder, liver damage, renal unsteady gait, convulsions, increase in
Ciprofloxacin 250 mg Tablet Ciprobay quinolones. Children, adolescents, pregnancy & NSAIDs, antineoplastics, immunosuppressants,
strains single dose of 250 mg impairment. Avoid prolonged exposure to sunlight intracranial pressure, anxiety states, nightmares,
lactation cyclosporin, warfarin, glibenclamide,
confusion, depression, hallucinations, impaired
taste & smell, visual disturbances, tinnitus,
insomnia, peripheral paralgesia, sweating,
Treatment of infections due to susceptible bacterial ADULT: 125-750 mg twice daily. Acute gonorrhoea: a Epilepsy, CNS disorder, liver damage, renal unsteady gait, convulsions, increase in
Ciprofloxacin 500 mg Tablet Ciprobay quinolones. Children, adolescents, pregnancy & NSAIDs, antineoplastics, immunosuppressants,
strains single dose of 250 mg impairment. Avoid prolonged exposure to sunlight intracranial pressure, anxiety states, nightmares,
lactation cyclosporin, warfarin, glibenclamide,
confusion, depression, hallucinations, impaired
taste & smell, visual disturbances, tinnitus,
i) 2 drops every 15 minutes for first 6 hours, then 2

drops every 30 minutes for the rest of the day. Second Prolonged use may result in overgrowth of
Local burning or discomfort, itching, lid oedema,
Ciprofloxacin HCl 0.3% Ophthalmic day : 2 drops every hour. Subsequent days (3rd - 14th nonsusceptible organisms. Discontinue use at first History of hypersensitivity to ciprofloxacin or
Ciloxan i) For corneal ulcer ii) For bacterial conjunctivitis tearing, white crystalline precipitates which Not known
Solution day) : 2 drops every 4 hours. ii) 1 - 2 drops 2 hourly into appearance of skin rash or other sign of other quinolones
resolve
the conjunctival sac while awake for 2 days and 1-2 hypersensitivity reactions. Children less than 1 year
drops 4 hourly while awake for the next 5 days
Germ cell tumours: 20 mg/m2 daily for 5 days every 3
Acute renal failure, chronic renal insufficiency,
weeks for 3 - 4 courses. Ovarian tumours: 75 mg/m2
Monitor blood counts, renal and neurologic function. myelosuppression, severe nausea and vomiting, Hypersensitivity to cisplatin/platinum-containing
once every 3 weeks as part of combination therapy or Sodium thiosulphate, bleomycin. If platinum
Protect from light. Materials used to ototoxicity, peripheral neuropathy, autonomic products, pre-exisiting renal insufficiency,
Cisplatin (Cis-Platinum) 10 mg Germ cell tumours, ovarian tumours, adult solid 100 mg/m2 IV once every 3 weeks as a single agent. compound is used with taxane, to be given after
Platinul prepare/administer cisplatin should not contain neuropathy, electrolyte disturbances (eg myelosuppression, hearing impairment.
Injection tumours, lymphomas Baseline creatinine clearance, pretreatment hydration taxane, live vaccine, azidamfenicol,
aluminium. Mandatory pre-hydration and post- hypokalemia, hypomagnesemia), bone marrows Pregnancy, lactation, peripheral neuropathy,
and forced diuresis are mandatory. CHILD: 100mg/m2 aminoglycosides
hydration with mannitol diuresis and ears, seizures, loss of hearing, deafness or severe bone marrow suppression
over 6 hours once every 3 weeks. Lymphomas: Refer
vestibular toxicity
to protocols
Germ cell tumours: 20 mg/m2 daily for 5 days every 3
Acute renal failure, chronic renal insufficiency,
weeks for 3 - 4 courses. Ovarian tumours: 75 mg/m2
Monitor blood counts, renal and neurologic function. myelosuppression, severe nausea and vomiting, Hypersensitivity to cisplatin/platinum-containing
once every 3 weeks as part of combination therapy or Sodium thiosulphate, bleomycin. If platinum
Protect from light. Materials used to ototoxicity, peripheral neuropathy, autonomic products, pre-exisiting renal insufficiency,
Cisplatin (Cis-Platinum) 50 mg Germ cell tumours, ovarian tumours, adult solid 100 mg/m2 IV once every 3 weeks as a single agent. compound is used with taxane, to be given after
Platinul prepare/administer cisplatin should not contain neuropathy, electrolyte disturbances (eg myelosuppression, hearing impairment.
Injection tumours, lymphomas Baseline creatinine clearance, pretreatment hydration taxane, live vaccine, azidamfenicol,
aluminium. Mandatory pre-hydration and post- hypokalemia, hypomagnesemia), bone marrows Pregnancy, lactation, peripheral neuropathy,
and forced diuresis are mandatory. CHILD: 100mg/m2 aminoglycosides
hydration with mannitol diuresis and ears, seizures, loss of hearing, deafness or severe bone marrow suppression
over 6 hours once every 3 weeks. Lymphomas: Refer
vestibular toxicity
to protocols
Modest increase of circulating theophylline or
Nausea, dyspepsia, abdominal pain & diarrhoea.
carbamazepine levels. May potentiate effects of
Only for i) treatment of complicated respiratory tract i) 250 - 500 mg twice daily. Up to 6 - 14 days ii) 500 mg Headache & skin rash. Reversible hearing loss. Known hypersensitivity to macrolides. Patients
Impaired hepatic function & moderate to severe warfarin or digoxin. May alter metabolism of
Clarithromycin 250 mg Tablet Klacid infection not responding to standard macrolides ii) twice daily with omeprazole & amoxicillin. Up to 2 Alteration of sense of smell with taste perversion. receiving terfenadine therapy with pre-existing
renal impairment terfenadine resulting in increased levels of
eradication of Helicobacter pylori infection weeks Glossitis, stomatitis, oral monilia, tongue cardiac abnormalities or electrolyte disturbances
terfenadine. Inhibition of metabolism with
discoloration, tooth discoloration (reversible)
ritonavir
Impaired hepatic function and moderate to severe
renal impairment. Absence of proven or strongly
Nausea, dyspepsia, abdominal pain and
suspected infection; increased risk of developing
diarrhoea. Headache and skin rash. Reversible Modest increase of circulating theophylline or
drug-resistant bacteria. Acute porphyria, history of Known hypersensitivity to macrolides. Patients
hearing loss. Alteration of sense of smell with carbamazepine levels. May potentiate effects of
concomitant therapy with ranitidine, bismuth citrate receiving terfenadine therapy with pre-existing
Only for treatment of complicated respiratory tract taste perversion. Glossitis, stomatitis, oral warfarin or digoxin. May alter metabolism of
Clarithromycin 500 mg Injection Klacid 1 g daily in 2 divided doses therapy is not recommended Pseudomembranous cardiac abnormalities or electrolyte disturbances.
infection not responding to standard macrolides monilia, tongue discoloration, tooth discoloration terfenadine resulting in increased levels of
colitis may occur; consider this diagnosis in patients Concomitant cisapride, pimozide, astemizole,
(reversible), liver failure, immune hypersensitivity terfenadine. Inhibition of metabolism with
who develop diarrhea during therapy . Renal terfenadine, ergotamine or dihydroergotamine
reaction (severe), anaphylaxis, Stevens-Johnson ritonavir
impairment, severe; dosage adjustment needed;
syndrome, toxic epidermal necrolysis
when CrCl is less than 25 mL/min, concurrent use of
ranitidine bismuth citrate is not recommended.
Impaired hepatic function and moderate to severe
renal impairment. Absence of proven or strongly
Nausea, dyspepsia, abdominal pain and
suspected infection; increased risk of developing
diarrhoea. Headache and skin rash. Reversible Modest increase of circulating theophylline or
drug-resistant bacteria. Acute porphyria, history of Known hypersensitivity to macrolides. Patients
CHILD: 8 - 12 years: 30 - 40 kg 10 mL, 4 - 8 years: 20 - hearing loss. Alteration of sense of smell with carbamazepine levels. May potentiate effects of
concomitant therapy with ranitidine, bismuth citrate receiving terfenadine therapy with pre-existing
Treatment of complicated respiratory tract infections 29 kg 7.5 mL, 2 - 4 years: 12 - 19 kg 5 mL, 1 - 2 years: taste perversion. Glossitis, stomatitis, oral warfarin or digoxin. May alter metabolism of
Clarithromycin Granules 125 mg/5 ml Klacid therapy is not recommended. Pseudomembranous cardiac abnormalities or electrolyte disturbances.
not responding to standard macrolides 8 - 11 kg 2.5 mL, less than 8 kg: 7.5 mg/kg. To be given monilia, tongue discoloration, tooth discoloration terfenadine resulting in increased levels of
colitis may occur; consider this diagnosis in patients Concomitant cisapride, pimozide, astemizole,
twice daily (reversible), liver failure, immune hypersensitivity terfenadine. Inhibition of metabolism with
who develop diarrhea during therapy. Renal terfenadine, ergotamine or dihydroergotamine
reaction (severe), anaphylaxis, Stevens-Johnson ritonavir
impairment, severe; dosage adjustment needed;
syndrome, toxic epidermal necrolysis
when CrCl is less than 25 mL/min, concurrent use of
ranitidine bismuth citrate is not recommended
History of GI disease, especially colitis. Renal or
i) ADULT: 150 - 300 mg every 6 hours; up to 450 mg Diarrhoea occasionally with acute colitis
i) Skin and soft tissue infections, bone& joint infections hepatic impairment. Perform periodic liver and
every 6 hours in severe infections; CHILD: 3 - 6 mg/kg (discontinue), abdominal pain, GI upsets, skin
ii) Cerebral toxoplasmosis iii) Children less than 8 kidney function tests with prolonged therapy and in
Clindamycin HCl 300 mg Capsule Lincocin every 6 hours ii) 600 mg 6 hourly for 6 weeks iii) reactions, jaundice, hematopoietic changes, Hypersensitivity to clindamycin or lincomycin Neuromuscular blockers, erythromycin
years old:Treatment and prophylaxis of malaria in neonates and infants. Discontinue immediately if
10mg/kg twice a day, in combination with quinine. The pseudomembranous enterocolitis, pruritus,
combination with quinine, as an alternative to doxycline diarrhoea or colitis develops. Pregnancy and
combination to be given for 7 days vaginitis
lactation
Diarrhoea, occasionally associated with severe
i) ADULT: 0.6 - 2.7 g daily (in 2 - 4 divided doses); up to
colitis, skin reactions, jaundice, haematopoietic
4.8 g daily; CHILD over 1 month, 15 - 25 mg/kg/day or New borns & infants; impaired hepatic or renal
Clindamycin Phosphate 150 mg/ml i) Skin and soft tissue infections, bone & joint infections changes. Local irritation, pain at IM injection site. Hypersensitivity to clindamycin or lincomycin.
Lincocin 350 mg/m2/day in 3 - 4 divided doses ii) 1200 mg every function; diarrhoea. Patients receiving Neuromuscular blockers, erythromycin
Injection ii) Cerebral toxoplasmosis Thrombophlebitis may occur with IV injection. Patients with diarrhoea
6 hours for 3 weeks followed by 300 mg orally every 6 neuromuscular blockers
Rarely, cardiopulmonary arrest & hypotension
hours for another 3 weeks
following too rapid IV administration
Short term treatment only of more resistant dermatoses Apply sparingly once or twice daily, changing to lower
INFANTS and CHILD: prolonged and continuous Rosacea, acne vulgaris, skin lesions caused by
eg. psoriasis, recalcitrant eczemas, lichen planus, potency therapy as soon as condition is controlled. For Local atrophic skin changes, hypercorticism,
use, pregnancy, avoid contact with eyes. Do not use viral, fungal and bacterial infections.
Clobetasol Propionate 0.05% Cream Dermovate discoid lupus erythematosus and other conditions mild to moderate use maximum for 2 weeks. For burning, stinging, irritation and adrenal Not known
for greater than 2 consecutive weeks or with Hypersensitivity to clobetasol or other
which do not respond satisfactorily to less potent moderate to severe maximum duration 4 consecutive suppression
occlusive dressing corticosteroid
steroids weeks. Max: 50 g/week
Short term treatment only of more resistant dermatoses Apply sparingly once or twice daily, changing to lower
INFANT and CHILD: prolonged and continuous use, Rosacea, acne vulgaris, skin lesions caused by
eg. psoriasis, recalcitrant eczemas, lichen planus, potency therapy as soon as condition is controlled. For Local atrophic skin changes, hypercorticism,
Clobetasol Propionate 0.05% pregnancy, avoid contact with eyes. Do not use for viral, fungal and bacterial infections.
Dermovate discoid lupus erythematosus and other conditions mild to moderate use maximum for 2 weeks. For burning, stinging, irritation and adrenal Not known
Ointment greater than 2 consecutive weeks or with occlusive Hypersensitivity to clobetasol or other
which do not respond satisfactorily to less potent moderate to severe maximum duration 4 consecutive suppression
dressing corticosteroid
steroids weeks. Max:50 g/week
Infants and children, prolonged and continuous use, Hypersensitivity to clobetasone or other Skin lesions caused by viral, fungal and bacterial
Apply up to four times daily until condition improves,
Clobetasone Butyrate 0.05% Cream Eumovate Eczema and dermatitis of all types pregnancy. Discontinue if secondary infection corticosteriods. Transient adrenal suppression. infections. Hypersensitivity to clobetasone or Not known
then reduce frequency
develops, avoid prolonged application to face Pigmentation changes and hypertrichosis other corticosteroids
Infants and children, prolonged and continuous use, Hypersensitivity to clobetasone or other Skin lesions caused by viral, fungal and bacterial
Clobetasone Butyrate 0.05% Apply up to four times daily until condition improves,
Eumovate Eczema and dermatitis of all types pregnancy. Discontinue if secondary infection corticosteriods. Transient adrenal suppression. infections. Hypersensitivity to clobetasone or Not known
Ointment then reduce frequency
develops, avoid prolonged application to face Pigmentary changes and hypertrichosis other corticosteroids
Hypocalcaemia, gastrointestinal tract Hypersensitivity to Clodronate, bisphosphonate

History of hypoparathyroidism and hypocalcaemia, Aminoglicoside, aspirin, NSAIDs, loop diuretics,
disturbances, elevated serum creatinine, or any component of the formulation, severe
Clodronate 800 mg Tablet Bonefos Treatment of hypercalcaemia due to malignancy 2 tablets in single or two divided doses food may reduce absorption, renal impairment, ranitidine, food, antacids and drugs containing
angioedema, urticaria, proteinuria, gastrointestinal inflammation, renal impairment,
pregnancy, lactation. Fe, Mg or manganese
bronchospasm pregnancy, breast feeding
Avoid treatment if possible in patients with abdominal
i) ADULT: 100 mg each other day or 50 mg daily after
pains, diarrhoea, liver or kidney damage. Treatment
i) Previously untreated leprosy patients ii) Leprosy food. Maximum: 200 mg/day. CHILD: 1 - 2 mg/kg/day. Reversible reddish to dark brown discoloration, Concurrent use of phenytoin and clofazimine
with daily doses more than 100 mg; not to be used
Clofazimine 100 mg Capsule Lamprene patients resistant to sulphones iii) Suppression of lepra Maximum: 100 mg/day ii) 100 mg daily iii) 200 - 300 mg non-specific skin reactions, GI effects including Hypersensitivity to clofazimine products may result in reduced phenytoin serum
for more than 3 months. Persistent diarrhoea or
reactions usually effective. Treatment with minimum suppression eosinophilic enteropathy concentrations and loss of phenytoin efficacy
vomiting; patient should be hospitalised. Pregnancy,
dose continued for at least 6 months
lactation
Avoid treatment if possible in patients with abdominal
i) ADULT: 100 mg each other day or 50 mg daily after
pains, diarrhoea, liver or kidney damage. Treatment
i) Previously untreated leprosy patients ii) Leprosy food. Maximum: 200 mg/day. CHILD: 1 - 2 mg/kg/day. Reversible reddish to dark brown discoloration, Concurrent use of phenytoin and clofazimine
with daily doses more than 100 mg; not to be used
Clofazimine 50 mg Capsule Lamprene patients resistant to sulphones iii) Suppression of lepra Maximum: 100 mg/day ii) 100 mg daily iii) 200 - 300 mg non-specific skin reactions, GI effects including Hypersensitivity to clofazimine products may result in reduced phenytoin serum
for more than 3 months. Persistent diarrhoea or
reactions usually effective. Treatment with minimum suppression eosinophilic enteropathy concentrations and loss of phenytoin efficacy
vomiting; patient should be hospitalised. Pregnancy,
dose continued for at least 6 months
lactation
Danazol can results in inhibition of response to
Pelvic examination prior to initial treatment, clomifene. Ethinyl estradiol can results in
50 mg daily from 2nd - 6th or 5th - 9th day of menstrual Pregnancy, uncontrolled thyroid or adrenal
ophthalmological evaluation in patients developing Blurred vision, vasomotor flushing, abdominal suppression of response to ethinyl estradiol.
cycle. Increase dose gradually by increments of 50 mg dysfunction, liver disease, abnormal uterine
Clomifene Citrate 50 mg Tablet Clomid Anovulatory infertility visual symptoms, multiple pregnancies can occur, pain and ovarian enlargement (which may be When used concomitantly with gonadorelin
if there is no response until a dosage of 200 mg daily is bleeding, ovarian cysts, organic intracranial
ovarian hyperstimulation syndrome and abnormal part of the ovarian hyperstimulation syndrome) acetate gonadotrophins (FSH), it may increase
achieved lesion
ovarian enlargement may occur the risk of ovarian hyperstimulation syndrome
(OHSS)
May diminish antihypertensive effect of
Initially 10 mg daily, increased gradually as necessary Anticholinergic reactions, cardiovascular effects,
Heart failure, acute myocardial infarction, adrenergic neuron inhibitors, class Ia and III
to 30 - 150 mg daily in divided doses or as a single insomnia, increase anxiety, skin rashes, Hypersensitivity to drug, concomitant/recent use
disturbance of cardiac conduction, low blood antiarrhythmics, anticholinergics, beta 2
Clomipramine HCI 25 mg Tablet Anafranil Depressive illness, obsessive-compulsive disorder dose at bedtime; max 250 mg daily. ELDERLY initially dizziness, somnolence, headache, constipation, of MAOIs, recent myocardial infarction, urinary
pressure, impaired liver function, impaired renal agonists, cimetidine, lithium, MAOIs,
10 mg daily increased carefully over approximately 10 fatigue, nausea, sweating, dyspepsia, libido retention, glaucoma, phaeochromocytoma
function, seizure disorder antipsychotics, phenytoin, SSRIs, indirect/mixed
days to 30 - 75 mg daily; CHILD not recommended changes, seizures
sympathomimetics
Drowsiness, ataxia, aggravation of seizure,
Avoid abrupt withdrawal, renal insufficiency,
i) ADULT: Initially, 1 mg given at night for 4 nights, fatigue, dizziness. Tiredness, sleepiness,
respiratory disease, acute intermittent porphyria, Alcohol may reduce the efficacy of treatment or
gradually increased over 2-4 week. Elderly: 500 mcg. lassitude, muscular hypotonia, muscle
uncontrolled open angle glaucoma, elderly, produce unexpected side effects. Increases
Maintenance: 4-8 mg daily. Maximum dosage: 20 weakness, light-headedness, ataxia, slowed
pregnancy, lactation, may exacerbate tonic seizures. Hypersensitivity to clonazepam products and phenytoin or primidone concentrations.
mg/day. CHILD: 5-12 years: Initially, 0.5 mg daily; 1-5 reaction, poor concentration, restlessness,
Patients with spinal or cerebellar ataxia, acute benzodiazepines, severe liver disease, narrow Combination with valproate may cause petit mal
Clonazepam 0.5 mg Tablet Rivotril i) Epilepsy ii) Non-epileptic myoclonus years: 0.25 mg daily. Maintenance (given in 2-4 divided confusion, agitation, excitability, irritability,
alcohol or drug intoxification, severe liver damage, angle glaucoma, respiratory depression, acute status epilepticus. Amiodarone, carbamazepine,
doses): 5-12 years: 3-6 mg daily; 1-5 years: 1-3 mg disorientation, anterograde amnesia, depression.
sleep apnoea, renal and hepatic diseases. History of pulmonary insufficiency theophylline. Barbiturates, hydantoins,
daily; infants: 0.5-1 mg daily. Maximum 200 Increased production of saliva or bronchial
depression and or suicide attempts. Simultaneous carbamazepine, other centrally-acting drugs,
mcg/kg/day. ii) ADULT: Initially, 250 mcg twice daily, secretions in infants and young children,
use of other anti-epileptics. Avoid driving and alcohol
increased after 3 days up to 1 mg daily. Max: 4 mg daily coordination disturbances, vertigo, anorexia,
operating machinery
visual disturbances, libido changes
Drowsiness, ataxia, aggravation of seizure,
Avoid abrupt withdrawal, renal insufficiency,
i) ADULT: Initially, 1 mg given at night for 4 nights, fatigue, dizziness. Tiredness, sleepiness,
respiratory disease, acute intermittent porphyria, Alcohol may reduce the efficacy of treatment or
gradually increased over 2-4 week. Elderly: 500 mcg. lassitude, muscular hypotonia, muscle
uncontrolled open angle glaucoma, elderly, produce unexpected side effects. Increases
Maintenance: 4-8 mg daily. Maximum dosage: 20 weakness, light-headedness, ataxia, slowed
pregnancy, lactation, may exacerbate tonic seizures. Hypersensitivity to clonazepam products and phenytoin or primidone concentrations.
mg/day. CHILD: 5-12 years: Initially, 0.5 mg daily; 1-5 reaction, poor concentration, restlessness,
Patients with spinal or cerebellar ataxia, acute benzodiazepines, severe liver disease, narrow Combination with valproate may cause petit mal
Clonazepam 2 mg Tablet Rivotril i) Epilepsy ii) Non-epileptic myoclonus years: 0.25 mg daily. Maintenance (given in 2-4 divided confusion, agitation, excitability, irritability,
alcohol or drug intoxification, severe liver damage, angle glaucoma, respiratory depression, acute status epilepticus. Amiodarone, carbamazepine,
doses): 5-12 years: 3-6 mg daily; 1-5 years: 1-3 mg disorientation, anterograde amnesia, depression.
sleep apnoea, renal and hepatic diseases. History of pulmonary insufficiency theophylline. Barbiturates, hydantoins,
daily; infants: 0.5-1 mg daily. Maximum 200 Increased production of saliva or bronchial
depression and or suicide attempts. Simultaneous carbamazepine, other centrally-acting drugs,
mcg/kg/day. ii) ADULT: Initially, 250 mcg twice daily, secretions in infants and young children,
use of other anti-epileptics. Avoid driving and alcohol
increased after 3 days up to 1 mg daily. Max: 4 mg daily coordination disturbances, vertigo, anorexia,
operating machinery
visual disturbances, libido changes
Acebutolol, betaxolol, carvedilol , labetalol,
Rapid detoxification in 4-5 days (use with naltrexone): 6 Rebound hypertension, atrioventricular block,
metoprolol, propranolol : exaggerated clonidine
mcg/kg ORALLY divided in 3 doses 6 to 8 hours apart Cerebrovascular disease, chronic renal failure, bradycardia, hypotension, depression, psychotic
Anticoagulant therapy (epidural dosing), bleeding withdrawal response (acute hypertension).
Rapid opiod detoxification combination use with the first day, increasing to 11 mcg/kg divided in 3 doses conduction disturbances, myocardial infarction, reactions, drowsiness, fatigue, irritability,
Clonidine HCl 0.025 mg Tablet Catapres site,hypersensitivity to clonidine or adhesive Ciclosporin: increased risk of ciclosporin toxicity
naltrexone given day two, tapering to 0.6 mcg/kg the third day. obstetric, post-partum or peri-operative pain vomiting, dry mouth, constipation, sexual
components (renal dysfunction, cholestasis, paraesthesias).
Rapid opioid detoxification for 7 days ( use with management dysfunction, hepatotoxicity and cutaneous
Dothiepin: decreased antihypertensive
naltrexone) : 0.1 to 0.2 mg every 4 hours as needed reactions
effectiveness. Naloxone : hypertension
Avoid for first few days after MI and for 7 days after
ischaemic stroke; not recommended in unstable
angina, coronary artery bypass grafting and
percutaneous transluminal coronary angioplasty;
patients at risk of increased bleeding from trauma, Cytochrome P450 effect. Amiodarone, cisapride,
surgery or other pathological conditions; discontinue ciclosporin, diltiazem, irbesartan, losartan, oral
Prevention of myocardial infarct, stroke or established 7 days before elective surgery if antiplatelet effect GI bleeding, purpura, bruising haematoma, hypoglycemics, paclitaxel, phenytoin, quinidine,
peripheral arterial disease. As second/third line not desirable, liver impairment, renal impairment, epistaxis, haematuria, ocular haemorrhage, intra Active pathological bleeding such as peptic ulcer sildenafil, tamoxifen, verapamil, warfarin, aspirin,
Clopidogrel 75 mg Tablet Plavix 75 mg once daily
treatment in patients who are sensitive to acetylsalicylic pregnancy. Based on literature data, patients with cranial bleeding, abdominal pain, dyspepsia, & intracranial haemorrhage, breast feeding heparin, thrombolytics, NSAIDs, atorvastatin,
acid & intolerant to ticlopidine genetically reduced CYP2C19 function (intermediate gastritis & constipation, rash, pruritus erythromycin, clarithromycin. Concomitant use of
or poor metabolisers) have lower systemic exposure the drugs that inhibit CYP2C19 should be
to the active metabolite of clopidogrel and discouraged
diminished antiplatelet responses, and generally
exhibit higher cardiovascular events rates following
myocardial infarction than do patients with normal
CYP2C19 function
Misplaced injections may paralyse nearby
muscle groups and excessive doses may
paralyse distant muscle, influenza-like
Anaphylaxis and corneal exposure.Subclinical or Generalised disorders of muscle activity eg.
Clostridium Botulinum Toxin Type A i) Focal dystonias ii) Hemifacial spasm iii) Spasticity syndrome. Exacerbation of existing eyelid Effects enhanced by aminoglycosides and non-
Botox 20 - 200 units 3 months once clinical evidence of marked defective neuromuscular myasthenia gravis, bleeding disorders,
100 units including cerebral palsy abnormalities, ptosis, diplopia, spread of the depolarizing muscle relaxant
transmission pregnancy and breast feeding
paralytic effect to mid-facial muscles, keratitis,
dry eyes, minor bruising, lid swelling, burning
sensation, dysphagia
Misplaced injections may paralyse nearby
muscle groups and excessive doses may
paralyse distant muscle, influenza-like
Anaphylaxis and corneal exposure. Subclinical or Generalised disorders of muscle activity eg.
Clostridium Botulinum Toxin Type A i) Focal dystonias ii) Hemifacial spasm iii) Spasticity syndrome. Exacerbation of existing eyelid Effects enhanced by aminoglycosides and non-
Dysport 20 - 200 units 3 months once clinical evidence of marked defective neuromuscular myasthenia gravis, bleeding disorders,
500 units including cerebral palsy abnormalities, ptosis, diplopia, spread of the depolarizing muscle relaxant
transmission pregnancy and breast feeding
paralytic effect to mid-facial muscles, keratitis,
dry eyes, minor bruising, lid swelling, burning
sensation, dysphagia
Rub in gently onto affected and surrounding skin 2 or 3
Cutaneous candidiasis, Tinea corporis, Tinea cruris, Contact with eyes and mucous menbranes should
Clotrimazole 1% Cream Canesten times daily continuing for about 2 weeks beyond the Skin reactions, contact dermatitis, pruritis Hypersensitivity to clotrimazole Not known
Tinea pedis and Tinea versicolor be avoided
dissapearance of all symptoms
Otomycosis; concomitant therapy with antibiotics and Perforated eardrums, otitis media, pegnancy and
Clotrimazole 1% Ear Drop Candid Ear Drops 4 to 5 drops 3 to 4 times daily local irritation Hypersensitive to clotrimazole Not known
corticosteroid ear drops lactation
Stinging, skin rash, blistering, burning, peeling,
Cutaneous candidiasis, tinea orporis, tinea cruris, tinea Apply gently onto affected and surrounding skin area 2
Clotrimazole 1% Solution Canesten Infant and child: not to use more than once daily redness or other sign of skin irritation not present Hypersensitivity to any component Not known
pedis and tinea versicolor or 3 times daily continuing for 2-4 weeks
before using this medicine
Concurrent use with betamethasone may result
Monitor hepatic function in patients with pre-existing in increased susceptibility to skin infection or
Local irritation or skin reaction and mild burning,
200 mg once daily, preferably at bedtime for three hepatic impairment, not for ophthalmic use and enhanced organism growth. Concurrent use with
Clotrimazole 200 mg Vaginal Tablet Vaginal candidiasis nausea, vomiting, troches, increased liver Hypersensitivity to Clotrimazole
consecutive days vaginal use in pregnant patients should be tacrolimus may increase plasma concentration of
enzymes
supervised by a physician tacrolimus and cause toxicity (nephrotoxicity,
hyperglycaemia, hyperkalaemia), fentanyl
Concurrent use with betamethasone may result

Monitor hepatic function in patients with pre-existing in increased susceptibility to skin infection or
Local irritation or skin reaction and mild burning,
hepatic impairment, not for ophthalmic use and enhanced organism growth. Concurrent use with
Clotrimazole 500 mg Vaginal Tablet Vaginal candidiasis 500 mg as a single one-time dose nausea, vomiting, troches, increased liver Hypersensitivity to clotrimazole
vaginal use in pregnant patients should be tacrolimus may increase plasma concentration of
enzymes
supervised by a physician tacrolimus and cause toxicity (nephrotoxicity,
hyperglycaemia, hyperkalaemia), fentanyl
Renal impairment. Neonates born to mothers
Cloxacillin Sodium 125 mg/5 ml Treatment of susceptible bacterial infections, notably CHILD 2 - 10 years: 250 mg 6 hourly, less than 2 years: Probenecid impairs renal excretion. Decreases
Orbenin hypersensitive to penicillin. Hypersensitivity to Occasional rashes, GI upsets, anaphylaxis Hypersensitivity to cloxacillin products/penicillins
Suspension penicillinase-producing staphylococci 125 mg 6 hourly anticoagulant effect
cephalosporins
ADULT: 250 - 500 mg every 6 hours. CHILD: 2 - 10 Renal impairment. Neonates born of mothers
Treatment of susceptible bacterial infections, notably Probenecid impairs renal excretion. Decreases
Cloxacillin Sodium 250 mg Capsule Orbenin years: 250 mg 4 times daily; less than 2 years: 125 mg hypersensitive to penicillin. Hypersensitivity to Occasional rashes, GI upsets, anaphylaxis Hypersensitivity to cloxacillin products/penicillins
penicillinase-producing staphylococci anticoagulant effect
4 times daily cephalosporins
ADULT: 250 to 500 mg every 6 hours depending on Allopurinol, chloramphenicol. Probenecid impairs
History of asthma or allergic-type reactions to other
Treatment of susceptible bacterial infections, notably type and severity of infection. CHILD less than 20 kg: Fever, rash, nausea, vomiting, diarrhoea, renal excretion. Anticoagulant effect is
Cloxacillin Sodium 250 mg Injection Orbenin medications, overgrowth of nonsusceptible Hypersensitivity to cloxacillin or penicillins
penicillinase-producing staphylococci infections 25 to 50 mg/kg/day in equally divided doses every 6 hepatotoxicity, anaphylaxis decreased. Tetracycline, oestrogen-containing
organisms
hours oral contraceptives
ADULT: 250 to 500 mg every 6 hours depending on Allopurinol, chloramphenicol. Probenecid impairs
History of asthma or allergic-type reactions to other
Treatment of susceptible bacterial infections, notably type and severity of infection. CHILD less than 20 kg: Fever, rash, nausea, vomiting, diarrhoea, renal excretion. Anticoagulant effect is
Cloxacillin Sodium 500 mg Injection Orbenin medications, overgrowth of nonsusceptible Hypersensitivity to cloxacillin or penicillins
penicillinase-producing staphylococci infections 25 to 50 mg/kg/day in equally divided doses every 6 hepatotoxicity, anaphylaxis decreased. Tetracycline, oestrogen-containing
organisms
hours oral contraceptives
Patients who are elderly, cachectic, or have serious
underlying medical illnesses; cardiovascular and or
pulmonary disease; discontinue treatment if Hyperglycemia, agranulocytosis, sedation,
myocarditis is suspected; history of seizures; history salivation, cardiovascular effects, dizziness /
Tramadol, carbamazepine, fluoxetine, sertraline,
of neuroleptic malignant syndrome; rapid escalation vertigo, seizures, drowsiness, confusion, blurred
fluvoxamine, erythromycin, phenobarbitone,
of dose, prostatic hypertrophy, hypotension, vision, dry mouth, jaundice, leucopenia, Severe hepatic and renal impairment,
phenytoin, rifampicin, cimetidine,
impaired renal or liver function, seizure disorder, neuroleptic malignant syndrome, anticholinergic myeloproliferative disorders, uncontrolled
benzodiazepines, other antipsychotics, tricyclic
hyperglycemia and diabetes mellitus. WBC & toxicity, hepatitis, hypotension, syncope, epilepsy, pregnancy, lactation, coma,
antidepressants, valproic acid derivatives.
Initial dose : 12.5 mg ( once or twice ) daily, increase absolute neutrophil counts (weekly during the 1st 18 constipation, tremor, weight gain, tachycardia, hypersensitivity to clozapine products,
Alcohol, MAOIs, CNS depressants, narcotics,
Clozapine 100 mg Tablet Clozaril Treatment of resistant schizophrenia slowly in steps of 25 - 50 mg up to 300 mg daily within 2 week, at least monthly thereafter) can be performed, hypersalivation. Eosinophilia, ketoacidosis, myocarditis with clozapine history,
antihistamines, anticholinergic drugs,
- 3 weeks. Maximum 900 mg/day eosinophilia, thrombocytopenia. Concurrent use of hyperosmolar coma, convulsions, ECG changes, agranulocytosis with clozapine history (except
antihypertensive agents, adrenaline, drugs with
drugs with a substantial potential to depress bone circulatory collapse, arrhythmias, myocarditis, due to previous chemotherapy), WBC less than
resp depressant effects, omeprazole, cimetidine,
marrow function & of long-acting depot cardiomyopathy, thromboembolism, aspiration of 3500, GI/GU obstruction, narrow angle
carbamazepine, SSRIs, lithium, azole
antipsychotics should be avoided. Caution when ingested food, intestinal obstruction, ileus, faecal glaucoma, CNS depression
antimycotics, protease inhibitors, caffeine,
patients drive vehicles or operate machinery. Narrow- impaction, hepatitis, pancreatitis, fulminant
nicotine
angle glaucoma, chronic constipation, , lactation, hepatic necrosis, interstitial nephritis, neuroleptic
pregnancy. Monitoring of standing & supine BP is malignant syndrome, unexplained sudden death
necessary during the 1st few week of treatment in
patients with Parkinson's disease
Patients who are elderly, cachectic, or have serious

underlying medical illnesses; cardiovascular and or
pulmonary disease; discontinue treatment if Hyperglycemia, agranulocytosis, sedation,
myocarditis is suspected; history of seizures; history salivation, cardiovascular effects, dizziness /
Tramadol, carbamazepine, fluoxetine, sertraline,
of neuroleptic malignant syndrome; rapid escalation vertigo, seizures, drowsiness, confusion, blurred
fluvoxamine, erythromycin, phenobarbitone,
of dose, prostatic hypertrophy, hypotension, vision, dry mouth, jaundice, leucopenia, Severe hepatic and renal impairment,
phenytoin, rifampicin, cimetidine,
impaired renal or liver function, seizure disorder, neuroleptic malignant syndrome, anticholinergic myeloproliferative disorders, uncontrolled
benzodiazepines, other antipsychotics, tricyclic
hyperglycemia and diabetes mellitus. WBC & toxicity, hepatitis, hypotension, syncope, epilepsy, pregnancy, lactation, coma,
antidepressants, valproic acid derivatives.
Initial dose : 12.5 mg ( once or twice ) daily, increase absolute neutrophil counts (weekly during the 1st 18 constipation, tremor, weight gain, tachycardia, hypersensitivity to clozapine products,
Alcohol, MAOIs, CNS depressants, narcotics,
Clozapine 25 mg Tablet Clozaril Treatment of resistant schizophrenia slowly in steps of 25 - 50 mg up to 300 mg daily within 2 week, at least monthly thereafter) can be performed, hypersalivation. Eosinophilia, ketoacidosis, myocarditis with clozapine history,
antihistamines, anticholinergic drugs,
- 3 weeks. Maximum 900 mg/day eosinophilia, thrombocytopenia. Concurrent use of hyperosmolar coma, convulsions, ECG changes, agranulocytosis with clozapine history (except
antihypertensive agents, adrenaline, drugs with
drugs with a substantial potential to depress bone circulatory collapse, arrhythmias, myocarditis, due to previous chemotherapy), WBC less than
resp depressant effects, omeprazole, cimetidine,
marrow function & of long-acting depot cardiomyopathy, thromboembolism, aspiration of 3500, GI/GU obstruction, narrow angle
carbamazepine, SSRIs, lithium, azole
antipsychotics should be avoided. Caution when ingested food, intestinal obstruction, ileus, faecal glaucoma, CNS depression
antimycotics, protease inhibitors, caffeine,
patients drive vehicles or operate machinery. Narrow- impaction, hepatitis, pancreatitis, fulminant
nicotine
angle glaucoma, chronic constipation, , lactation, hepatic necrosis, interstitial nephritis, neuroleptic
pregnancy. Monitoring of standing & supine BP is malignant syndrome, unexplained sudden death
necessary during the 1st few week of treatment in
Coal Tar 1- 6 % in Betamethasone 17 - Dandruff, seborrhoeic dermatitis, atopic dermatitis, Avoid eyes, mucosa, genital, rectal areas, broken or
- Apply to the affected areas Dermatitis, folliculitis Hypersensitivity to any of its ingredients Not known
Valerate 0.01 % Ointment eczema and psoriasis inflammed skin
Absence of beneficial use when used previously.
Dandruff, seborrhoeic dermatitis, atopic dermatitis, Skin ulcerations, hypersensitivity reactions
Presence of folliculitis and acne vulgaris. Active
eczema and psoriasis. Used as a mild astringent for Apply sparingly to the affected area 1-3 times daily Avoid contact with eye, mucous membranes or including contact dermatitis. The use of
Coal Tar 1-9% Ointment - or inflammed psoriasis, weeping eczema, Not known
the skin, as a soothing and protective application in starting with low strength preparations broken skin ultraviolet light and coal tar may produce or
erythrodermic and generalized pustular
eczema and as a protective to slight excoriation aggravate folliculitis, erythema and a smarting
psoriasis, photosensitivity
Skin ulcerations, hypersensitivity reactions
Do not apply to acutely inflammed skin. Avoid including allergic contact dermatitis, Presence of folliculitis and acne vulgaris. Active
Dandruff, seborrhoeic dermatitis, atopic dermatitis, contact with eyes and do not apply coal tar aggravations of status varicosus. The use of or inflammed psoriasis, weeping eczema,
Coal Tar 20% Solution - Use 100 ml in a bath Not known
eczema and psoriasis preparations (other than bath emulsions) to genital ultraviolet light and coal tar may produce or erythrodermic and generalized pustular
or rectal areas aggravate herpes lesions keratocystomatosis, psoriasis, photosensitivity
folliculitis, erythema and a smarting
Avoid contact with eyes, mucous membranes or
broken skin. Avoid exposure to sun or strong
Coal Tar and Salicylic Acid (various Dandruff, seborrhoeic dermatitis, atopic dermatitis,
- Apply to the affected areas artificial light. Should not be used for acute or Local irritation Skin infection Not known
concentrations) Ointment eczema and psoriasis
pustular psoriasis or on inflammed skin. It stains
skin, hair, some fabrics, plastics, and enamel
To produce local anaesthesia or vasoconstriction Maximum total dose recommended for application to Can cause addiction, arrythmia, palpitation,
Never given by injection due to its marked Interacts with some drugs and can cause
Cocaine 10% Solution - during endoscopic nasal surgery, turbinectomy the nasal mucosa in healthy adult is 1.5 to 2 mg/kg of a Avoid in porphyria and direct sunlight central nervous system stimulation, syncope,
sympathomimetic effcts arrhythmia.
septoplasty, polypectomy etc 10% cocaine solution seizure, coronary arteriosclerosis
Avoid eyes, mucosa, genital, rectal areas, broken or
Cocois Co. Ointment - Scalp psoriasis and severe seborrhoeic dermatitis Rub a small amount into the scalp gently Dermatitis, folliculitis Hypersensitivity to any of its ingredients Not known
inflammed skin
Reversible malabsorption of Vit B12, action
inhibited by acidifying agents & enhanced by
alkalinizing agents, cyclosporin, erythromycin.
Response to CNS depressants and
sympathomimetics may increase when used
concurrently with colchicine. Increased risk of
myopathy when used concurrently with
Bone marrow depression with aplastic anaemia, simvastatin. Potential risk of severe drug
peripheral neuritis, myopathy, hair loss, interactions, including death in certain patients
i) Initial dose, 0.5-1.2 mg, then 0.5-0.6 mg every hour
gastrointestinal disturbances, epigastric pain, treated with colchicine and concomitant P-
i) Acute gout and prophylaxis of recurrent gout. ii) until relief of pain is obtained or vomiting or diarrhoea Serious GI, renal, hepatic & cardiac disorders
diarrhoea, nausea, vomiting, myelosuppression, glycoprotein or strong CYP3A4 inhibitors such as
Leucocytoclastic Vasculitis either cutaneous or occurs (Maximum : 8 mg). The course should not be Pregnancy, lactation, children and elderly, GI and those with blood dyscrasias, hypersensitivity
abdominal pain, diarrhoea, gastrointestinal clarithromycin, ciclosporin, erythromycin, calcium
Colchicine 0.5 mg Tablet - systemic involvement, Behcet's syndrome, Urticarial repeated within 3 days. Prevention of attacks during disease, cardiac, renal and hepatic impairment. to colchicine, children under 2 years old,
haemorrhage, rashes, renal and hepatic damage channel antagonists (verapamil, diltiazem),
vasculitis, Systemic sclerosis, Sweet's syndrome and initial treatment with allopurinol or uricosuric drugs: 0.5 Prolonged therapy not recommended pregnancy, debilitated patients, SC/IM
in excessive doses. Rarely peripheral neuritis, telithromycin, ketoconazole, itraconazole, HIV
severe recalcitrant aphthous stomatitis mg 1-3 times daily. ii) 0.5 mg 1-3 times daily depends administration
myopathy, alopecia and with chronic therapy protease inhibitors and nefazodone. P-
on disease and severity, up to a maximum of 3 mg/day
blood disorders like agranulocytosis, aplastic glycoprotein or strong CYP3A4 inhibitors are not
anaemia to be used in patients with renal or hepatic
impairment who are taking cochicine. A dose
reduction or interruption of colchicine treatment
should be considered in patients with normal
renal and hepatic function if treatment with a P-
glycoprotein or a strong CYP3A4 inhibitors
required. Avoid consuming grapefruit and
grapefruit juice while using colchicine
Increases in haemoglobin levels, mild reductions

in diastolic blood pressure, headache and
Concomitant administration of antacids, milk, food,
dizziness, Bismuth encephalopathy; Concomitant administration of colloidal bismuth
and H2-receptor antagonists may impair efficacy,
characterized by ataxia, confusion, memory subcitrate with antacids may result in preferential
Colloidal Bismuth Subcitrate 120 mg Eradication therapy for Helicobacter Pylori in hepatic dysfunction, renal impairment (potential
De-Nol 240 mg twice daily for 1-2 weeks impairment, mood disturbances, myoclonus, Hypersensitivity to bismuth salts chelate formation. The effect of antacids on
Tablet combination with antibiotics and antisecretory drugs accumulation and bismuth neurotoxicity), toxicity
hallucinations, seizures, darkens tongue and gastric pH may also affect precipitation of
may occur with prolonged therapy due to
blackens faeces, nausea, diarrhoea, dyspepsia, colloidal bismuth subcitrate
sequestration of bismuth
elevations in aspartate transaminase levels,
acute renal failure, allergic skin rashes
Known or suspected pregnancy, including use
Changes in vaginal bleeding pattern and
for missed abortion or as a diagnostic test for
abnormal withdrawal bleeding or flow,
pregnancy. Oestrogen or progestin may cause
breakthrough bleeding, spotting, change in
fetal harm when administered to a pregnant
amount of cervical secretion, premenstrual like
woman. Known or suspected cancer of the
syndrome, cystitis like syndrome, increase in
breast. Known or suspected oestrogen-
Asthma, epilepsy, migraine, hypertension, cardiac or size of uterine leiomyomata, vaginal candidiasis,
dependent neoplasm. Hypersensitivity to
Conjugated Oestrogen 0.625 mg (14 renal dysfunction, endometrial hyperplasia, amenorrhoea, changes in cervical erosion.
One tablet of conjugated estrogen 0.625 mg tablet daily conjugated estrogens, medroxyprogesterone Rifampicin may reduce effectiveness. Ethanol
Tablet) & Medroxyprogesterone 5 mg Cyclic continuous regular bleed hormone replacement metabolic bone diseases, endometrial cancer, breast Nausea, cholestatic jaundice, changes in
Premelle Cycle 5 on days 1 through 14 and one tablet of conjugated (MPA), or any component of the formulation, may also increase the risk of osteoporosis. Folic
with Conjugated Oestrogen 0.625 mg therapy for woman with uterus cancer, gall bladder disease, pancreatitis, lactation. appetite, vomiting, abdominal cramps, bloating,
estrogen 0.625 mg daily on days 15 through 28 undiagnosed abnormal vaginal bleeding, history acid absorption may be decreased
(14 Tablet) Surgery, liver disorders, enlargement of uterine increased incidence of gall bladder disease,
of or current thrombophlebitis or venous
fibromyomata pancreatitis. Headache, dizziness, mental
thromboembolic disorders (including deep vein
depression, nervousness, migraine. Increase or
thrombosis, pulmonary embolism), active or
decrease in weight, oedema, changes in libido,
recent (within 1 year) arterial thromboembolic
fatigue, backache, reduced carbohydrate
disease (eg, stroke, myocardial infarction),
tolerance, aggravation of porphyria, pyrexia,
carcinoma of the breast, estrogen-dependent
anaphylactoid reactions, anaphylaxis
tumor, hepatic dysfunction or disease
Familial hyperlipoproteinaemia, uterine bleeding and
mastodynia, uterine fibroids, impaired liver function,
Nausea, endometrial cancer (postmenopausal),
fluid retention, hypocalcaemia and renal
oedema, weight changes, breast changes,
insufficiency, addition of a progesterone for seven or
i) Osteoporosis associated with oestrogen deficiency ii) headache migraine, steepening of corneal
more days of a cycle of oestrogen administration Oestrogen-dependent neoplasia, known or
Female hypoestrogenism iii) Vasomotor symptoms curvature, changes in libido, change in menstrual
Conjugated Oestrogens 0.3 mg Tablet Premarin i) 0.625 mg daily ii)& iii) 0.3 - 1.25 mg daily have reported a lowered incidence of endometrial suspected pregnancy, undiagnosed abnormal Rifampicin may reduce effectiveness
associated with oestrogen deficiency or atrophic flow, vomiting, aggravation of porphyria,
hyperplasia, gall bladder disease, patient who have vaginal bleeding
vaginitis and urethritis cholestatic jaundice, alopecia, breakthrough
been treated for endometrial carcinoma,
bleeding, spotting, amenorrhoea, bloating,
endometriosis, patient with pre-existing
dizziness
hypertension, fibrocystic disease of the breast,
migraine headache, uterine leiomyoma
Myocardia infarction, stroke, breast, endometrial and
ovarian cancer, pregnancy, gallbladder disease,
Pregnancy, known or suspected cancer of the
Management of moderate to severe vasomotor retinal vascular thrombosis, proptosis, diplopia,
Breast pain, breakthrough bleeding, breast and estrogen dependent neoplasia,
Conjugated Oestrogens 0.625 mg & symptoms associated with menopause, prevention and migraine, hypercalcaemia, fluid retention,
dysmenorrhea, spotting, breast tenderness or undiagnosed abnormal genital bleeding, active
Medroxyprogesterone Acetate 2.5 mg Premelle 2.5 management of postmenopausal osteoporosis, atropic 1 tablet daily hypertriglyceridemia, hepatic impairment, past Rifampin may reduce effectiveness
enlargement, discharge, arthralgias, leg cramp, thrombophlebitis or thromboembolic disorders,
Tablet vaginitis and atropic urethritis in post menopausal history of cholestatic jaundice, elevated blood
depression, vaginitis, weight changes liver dysfunction or disease. Active or recent
woman with intact uterus pressure, asthma, epilepsy, hypocalcaemia,
arterial thromboembolic disease
hypothyroidism, abnormal uterine bleeding,
depression
Familial hyperlipoproteinaemia, uterine bleeding and
mastodynia, uterine fibroids, impaired liver function,
Nausea, endometrial cancer (postmenopausal),
fluid retention, hypocalcaemia and renal
oedema, weight changes, breast changes,
insufficiency, addition of a progesterone for seven or
headache migraine, steepening of corneal
i) Osteoporosis ii) Female hypoestrogenism iii) more days of a cycle of oestrogen administration Oestrogen-dependent neoplasia, known or
Conjugated Oestrogens 0.625 mg i) 0.625 mg daily ii) 0.3 - 1.25 mg daily iii) 0.3 - 1.25 mg curvature, changes in libido, change in menstrual
Premarin Vasomotor symptoms or atrophic vaginitis and have reported a lowered incidence of endometrial suspected pregnancy, undiagnosed abnormal Rifampicin may reduce effectiveness
Tablet daily flow, vomiting, aggravation of porphyria,
urethritis hyperplasia, gall bladder disease, patient who have vaginal bleeding
cholestatic jaundice, alopecia, breakthrough
been treated for endometrial carcinoma,
bleeding, spotting, amenorrhoea, bloating,
endometriosis, patient with pre-existing
dizziness
hypertension, fibrocystic disease of the breast,
migraine headache, uterine leiomyoma
Intravaginally or topically 2 - 4 g daily depending on
severity of condition. Total dose not exceeding 4 g.
Administration should be cyclic, with 3 weeks on Oestrogen dependent neoplasia, known or
conjugated oestrogens and one week off. Oestrogens suspected pregnancy, undiagnosed abnormal
Conjugated Oestrogens 0.625 mg/g Atrophic vaginitis and post menopausal atrophic Systemic absorption may occur. Precautions as for
Premarin should be used for the shortest duration possible when Nausea, abdominal cramp, oedema, rash vaginal bleeding, thromboembolic disorders, Not known
Cream urethritis oral premarin should be considered
treating atrophic vaginitis. Every 3 to 6 months attempts neuro-ophthalmologic vascular disease, breast
should be made to taper or discontinue therapy and cancer (except metastatic disease therapy)
conjugated oestrogens should be titrated to give the
lowest possible dosage to control symptoms
Drug with low molecular weight, high water
Abdominal sepsis, previous abdominal surgery or Peritonitis, hernias, hyperglycaemia, protein
solubility, low volume of distribution, low protein
Continuous Ambulatory Peritoneal For chronic renal diseases requiring dialysis and acute severe inflammatory bowel disease. Dialysis malnutrition and catheter complications. Long-
binding and high renal clearance are most
Dialysis Solution containing 1.5% - therapy-resistance renal failure eg. prior to transfer to a Dose depending on clinical cases solutions should be warmed to body temperature term peritoneal dialysis results in progressive Not known
extensively removed by dialysis e.g.
Dextrose dialysis centre with dry heat because wet heat carries a risk of structural changes to the peritoneal membrane
aminoglycosides. Dialysis-induced changes in
microbial contamination ultimately resulting in dialysis failure
fluids and electrolytes
Uterine cramps and or abdominal pain, syncope,
bradycardia, other neurovascular episodes
Pregnancy, ectopic pregnancy or predisposing
Nulliparity, recent history of pelvic inflammatory during or immediately after insertion or removal
factors, malformations or distortions of uterus or
One unit intrauterine device to be inserted into the disease (PID), epilepsy, medical diathermy of of intra uterine devices, breakthrough bleeding,
cervix, active pelvic inflammatory disease (PID),
uterine cavity on the last day of the menstrual flow or in abdominal and sacral area, valvular heart disease, prolongation of menstruation, dysmenorrhoea,
Copper 250 mm2 Intrauterine Device Multiload MLCu Contraception presence or history of venereal disease, infected Not known
the first days afterwards. It is advised that the Multiload anaemia, severe dysmenorrhoea, uterine scars, back and leg pain, dyspareunia, pelvic
abortion within 3 months, undiagnosed vaginal
Cu 250 devices are replaced every 3 years endometrial polyps or endometriosis. Treatment with inflammatory disease (PID), abnormal vaginal
bleeding, coagulopathy, treatment with
corticosteroids or NSAIDs discharge, perforated uterus or cervix,
anticoagulant, disorders of copper-related
spontaneous abortion, septicaemia, ectopic
pregnancy. Urticarial allergic skin reactions
Uterine cramps and or abdominal pain, syncope,
bradycardia, other neurovascular episodes
Pregnancy, ectopic pregnancy or predisposing
Nulliparity, recent history of pelvic inflammatory during or immediately after insertion or removal
factors, malformations or distortions of uterus or
One unit intrauterine device to be inserted into the disease (PID), epilepsy, medical diathermy of of intra uterine devices, breakthrough bleeding,
cervix, active pelvic inflammatory disease (PID),
uterine cavity on the last day of the menstrual flow or in abdominal and sacral area, valvular heart disease, prolongation of menstruation, dysmenorrhoea,
Copper 375 mm2 Intrauterine Device Multiload MLCu Contraception presence or history of venereal disease, infected Not known
the first days afterwards. It is advised that the Multiload anaemia, severe dysmenorrhoea, uterine scars, back and leg pain, dyspareunia, pelvic
abortion within 3 months, undiagnosed vaginal
Cu 375 devices are replaced every 5 years endometrial polyps or endometriosis. Treatment with inflammatory disease (PID), abnormal vaginal
bleeding, coagulopathy, treatment with
corticosteroids or NSAIDs discharge, perforated uterus or cervix,
anticoagulant, disorders of copper-related
spontaneous abortion, septicaemia, ectopic
pregnancy. Urticarial allergic skin reactions
Severe irritant contact dermatitis and may
The tip of the crystal should be moistened by dipping in produce systemic toxicity, especially if applied to
Copper Sulphate Crystal - Wounds Skin exposure may result in severe irritation Dermal hypersensitivity reactions Not known
water and applied carefully to the lesion injured skin as occurred when copper sulfate
was previously used in burn treatment
Concurrent use with phenobarbital and
phenytoin may result in decreased
For salt losing congenital adrenal hyperplasia in 20-30 mg/m2 daily. Doses may be divided with two- Discontinue treatment by reducing the dosage Fluid and electrolyte disturbances, muscle corticosteriods effectiveness. Concurrent use
Cortisone Acetate 5 mg Tablet Cortef Hypersensitivity, systemic fungal infection
newborn and paediatric patients thirds in the morning and one-third late in the afternoon gradually weakness, peptic ulcer with aspirin may result in an increased risk of
gastrointestinal ulceration and subtherapeutic
aspirin serum concentration
i) and iii) Massage into affected area until the
medication is completely absorbed. Repeat as needed. Avoid contact with eyes, face, mouth and mucous
Apply 2 or 3 times daily ii) Apply topically (do not rinse membranes. Pregnancy. Avoid applying to inflamed Do not apply on nipples when breastfeeding,
Crotamiton 10 % Cream Eurax i) Pruritus ii) Scabies iii) Insect bite reactions Local skin irritation or contact allergy Not known
off), apply a second time and leave on skin for 24 - 48 skin or raw, oozing skin surfaces. Discontinue use of hypersensitivity to crotamiton
hours. For resistant scabies, treatment (2 applications crotamiton if severe skin irritation develops
at 24 hour interval) may be repeated after 1 week
i) Prophylaxis of anaemia: 250-1000 mcg IM every
month ii) Uncomplicated pernicious anaemia or Vitamin
B12 malabsorption: Initial 100 mcg daily for 5-10 days Hereditary optic atrophy, vitamin B12 therapy can
Diarrhoea, urticaria, pruritus, skin rash, Hypersensitivity to any component of Neomycin, aminosalicylic acid, histamine H2
i) Prophylaxis of anaemia ii) Uncomplicated pernicious followed by 100-200 mcg monthly until complete mask folic acid deficiency, hypokalaemia and risk of
Cyanocobalamin 0.1 mg Injection hypokalaemia, polycythemia vera, volume cyanocobalamin or hydroxycobalamin receptor antagonists, colchicine, oral
anaemia or Vitamin B12 malabsorption remission is achieved. Maintenance: 100 mcg monthly. gastric cancer is higher in patients with pernicious
overload formulations contraceptives, chloramphenicol
CHILD 30-50 mcg daily for 2 or more weeks (to a total anaemia
dose of 1-5mg). Maintenance: 100 mcg monthly to
sustain remission
i) Prophylaxis of anaemia: 250-1000 mcg IM every
month ii) Uncomplicated pernicious anaemia or Vitamin
B12 malabsorption: Initial 100 mcg daily for 5-10 days Hereditary optic atrophy, vitamin B12 therapy can
i) Prophylaxis of anaemia associated with Vitamin B12 Diarrhoea, urticaria, pruritus, skin rash, Hypersensitivity to any component of Neomycin, aminosalicylic acid, histamine H2
followed by 100-200 mcg monthly until complete mask folic acid deficiency, hypokalaemia and risk of
Cyanocobalamin 1 mg Injection deficiency ii) Uncomplicated pernicious anaemia or hypokalaemia, polycythemia vera, volume cyanocobalamin or hydroxycobalamin receptor antagonists, colchicine, oral
remission is achieved. Maintenance: 100 mcg monthly. gastric cancer is higher in patients with pernicious
Vitamin B12 malabsorption overload formulations contraceptives, chloramphenicol
CHILD 30-50 mcg daily for 2 or more weeks (to a total anaemia
dose of 1-5mg). Maintenance: 100 mcg monthly to
sustain remission
Hereditary optic atrophy, vitamin B12 therapy can
Diarrhoea, urticaria, pruritus, skin rash, Hypersensitivity to any component of Neomycin, aminosalicylic acid, histamine H2
ADULT 50-150 mcg daily. CHILD 50-105 mcg daily in 1- mask folic acid deficiency, hypokalaemia and risk of
Cyanocobalamin 50 mcg Tablet Vitamin B12 deficiency of dietary origin hypokalaemia, polycythemia vera, volume cyanocobalamin or hydroxycobalamin receptor antagonists, colchicine, oral
3 divided doses gastric cancer is higher in patients with pernicious
overload. formulations contraceptives, chloramphenicol
anaemia
The lacrimal sac should be compressed by digital Increased intraocular pressure, psychotic
pressure for two to three minutes after instillation to reactions and behavioural disturbances in
reduce excessive systemic absorption. Down's children, burning/irritation upon instillation,
1 drop every 5 - 10 minutes; not exceeding three times Untreated narrow-angle glaucoma, untreated Cyclopentolate may interfere with the ocular anti-
Cyclopentolate 0.2% with syndrome, angle-closure glaucoma, long-term use. photophobia, blurred vision and superficial
Cyclomydril Dilating agent for premature babies to produce rapid mydriasis. Observe infants closely for anatomically narrow angles, hypersensitivity to hypertensive action of carbachol, pilocarpine, or
Phenylephrine 1% Eye Drops Patient may experience sensitivity to light and should punctate keratitis, ataxia, incoherent speech,
at least 30 minutes any component of this preparation ophthalmic cholinesterase inhibitors
protect eyes in bright illumination during dilation. restlessness, hallucinations, hyperactivity,
Feeding intolerance may follow ophthalmic use of seizures, disorientation as to time and place, and
this product in infants failure to recognize people
1 to 2 drops of 0.5% to 2% solution in eye(s); may
repeat after 5 to 10 minutes if needed. Small INFANT :
Mild tachycardia, secretion decrease and action
single instillation of 1 drop of 0.5% solution in the eye; Cyclopentolate may interfere with antiglaucoma
Cyclopentolate 0.5% Eye Drops Cyclogyl Mydriasis and cycloplegia May impair ability to drive or operate machinery on the CNS, blurred vision, increased intraocular Narrow-angle glaucoma
apply pressure to nasolacrimal sac for 2 to 3 minutes; action of carbachol or pilocarpine
pressure, allergic reactions
observe infant closely for at least 30 minutes for signs
or symptoms of systemic absorption
1 - 2 drops several times a day. Refractory procedures,
Mild tachycardia, secretion decrease and action
ADULT : 1 drop of 0.5% solution. CHILD 6 - 12 years : Cyclopentolate may interfere with antiglaucoma
Cyclopentolate 1% Eye Drops Cyclogyl Mydriasis and cycloplegia May impair ability to drive or operate machinery on the CNS, blurred vision, increased intraocular Narrow-angle glaucoma
1 drop of 1% solution. CHILD less than 6 years : 1 - 2 action of carbachol or pilocarpine
pressure, allergic reactions
drops of 1% solution
i) ADULT: 600 - 750 mg/m2 IV once every 3 weeks as
part of combination regime. CHILD: Dose variable
depending on disease and protocol. Range 600 mg/m2
to 2 g/m2 infusion over 1 hour to 6 hours (lower doses
can be given as bolus). Care with pre and post-
hydration. Mesna to be given with doses more than 1
Myelosuppression, syndrome of inappropriate
i) Solid tumours (adult and paediatric), leukaemia, non- g/m2. Higher doses are used in haematopoetic stem Doxorubicin, cimetidine, thiazide diuretics.
ADH secretion, haemorrhagic cystitis, fibrosis of
Hodgkin's lymphoma, multiple myeloma ii) Severe cell transplant-refer to specific protocols ii) 750 mg/m2 Succinyl choline, halothane, nitrous oxide.
bladder, alopecia, nausea and vomiting,
lupus nephritis (Class III and IV) iii) Other systemic BSA monthly for 18 months iii) 750 mg/m2 BSA monthly Myelosuppression, renal/hepatic impairment, elderly Hypersensitivity to cyclophosphamide. Increased bone marrow depression with
Cyclophosphamide 1 g Injection Endoxan anorexia, diarrhoea, headache, rash, flushing of
vasculitis iv) Systemic lupus erythematosus, for 6 months. Dose can be adjusted up to 1,000 mg/m2 patients Pregnancy, lactation allopurinol, barbiturates, phenytoin,
face. Adverse reactions with high doses of
rheumatoid arthritis, polyarteritis nodosa, wegener BSA to achieve adequate leucocyte suppression iv) corticosteroids, chloramphenicol, interferon alfa.
cyclophophamide include heart failure and
granulomatosis v) Pemphigus vulgaris 500 - 1000 mg intravenously (Regime varies according Radiotherapy, live vaccines
interstitial pneumonitis
to indication). Starting dose may be given fortnightly
then at monthly intervals followed by 3 monthly intervals
v) 500 mg infusion on the 2nd day of the
dexamethasone-cyclophosphamide pulsed regime, the
cycle is repeated every 4 weeks up to 6 cycles or till
remission followed by oral cyclophosphamide
i) ADULT: 600 - 750 mg/m2 IV once every 3 weeks as
part of combination regime. CHILD: Dose variable
depending on disease and protocol. Range 600 mg/m2
to 2 g/m2 infusion over 1 hour to 6 hours (lower doses
can be given as bolus). Care with pre and post-
hydration. Mesna to be given with doses more than 1
Myelosuppression, syndrome of inappropriate
i) Solid tumours (adult and paediatric), leukaemia, non- g/m2. Higher doses are used in haematopoetic stem Doxorubicin, cimetidine, thiazide diuretics.
ADH secretion, haemorrhagic cystitis, fibrosis of
Hodgkin's lymphoma, multiple myeloma ii) Severe cell transplant-refer to specific protocols ii) 750 mg/m2 Succinyl choline, halothane, nitrous oxide.
bladder, alopecia, nausea and vomiting,
lupus nephritis (Class III and IV) iii) Other systemic BSA monthly for 18 months iii) 750 mg/m2 BSA monthly Myelosuppression, renal/hepatic impairment, elderly Hypersensitivity to cyclophosphamide. Increased bone marrow depression with
Cyclophosphamide 200 mg Injection Endoxan anorexia, diarrhoea, headache, rash, flushing of
vasculitis iv) Systemic lupus erythematosus, for 6 months. Dose can be adjusted up to 1,000 mg/m2 patients Pregnancy, lactation allopurinol, barbiturates, phenytoin,
face. Adverse reactions with high doses of
rheumatoid arthritis, polyarteritis nodosa, wegener BSA to achieve adequate leucocyte suppression iv) corticosteroids, chloramphenicol, interferon alfa.
cyclophophamide include heart failure and
granulomatosis v) Pemphigus vulgaris 500 - 1000 mg intravenously (Regime varies according Radiotherapy, live vaccines
interstitial pneumonitis
to indication). Starting dose may be given fortnightly
then at monthly intervals followed by 3 monthly intervals
v) 500 mg infusion on the 2nd day of the
dexamethasone-cyclophosphamide pulsed regime, the
cycle is repeated every 4 weeks up to 6 cycles or till
remission followed by oral cyclophosphamide
i) Solid tumours, leukaemia, lymphoma, autoimmune
i) ADULT: 50 - 100 mg/day. Monitor full blood count Doxorubicin, cimetidine, thiazide diuretics.
disorders, autoimmune bullous diseases, connective Myelosuppression, syndrome of inappropriate
(FBC), liver function, urine microscopy and renal Radiotherapy, live vaccines. Succinyl choline,
tissue disease, pyoderma gangrenosum ii) For severe ADH secretion, haemorrhagic cystitis, fibrosis of
function. CHILD, up to 1 year: 10 - 20 mg daily, 1 - 5 Myelosuppression, renal/hepatic impairment, elderly Hypersensitivity to cyclophosphamide. halothane, nitrous oxide. Increased bone marrow
Cyclophosphamide 50 mg Tablet Endoxan lupus nephritis (Class III & IV), systemic vasculitis and bladder, alopecia, nausea and vomiting,
years: 30 - 50 mg daily, 6 - 12 years: 50 - 100 mg daily patients Pregnancy, lactation depression with allopurinol, barbiturates,
steroid resistant/dependent nephrotic syndrome iii) anorexia, diarrhoea, headache, rash, flushing of
ii) 2 mg/kg/day for 3 - 4 months iii) 1 - 1.5 mg/kg/day phenytoin, corticosteroids, chloramphenicol,
Systemic lupus erythematosus (SLE), rheumatoid face
orally in divided doses interferon alfa
arthritis, polyarteritis nodosa, wegener granulomatosis
ADULT: Initial: 250 mg every 12 hours for 14 days, then
administer 0.5 - 1 g daily in 2 divided doses for 18 - 24 Reduce dose in renal impairment, monitor Severe renal impairment, epilepsy, depression,
Multi-Drug Resistance Tuberculosis treatment failure.
Cycloserine 250 mg Capsule - months (maximum daily dose: 1 g). CHILD: 10 - 20 haematological, renal, hepatic function, breast Vertigo, nausea, convulsion, psychosis, rashes severe anxiety, psychotic states, alcohol Alcohol, antiepileptics, phenytoin
(For respiratory physicians)
mg/kg/day in 2 divided doses up to 1 g/day for 18 - 24 feeding, pregnancy dependence
months
Diabetes, hypertension, varicose veins, otosclerosis,

multiple sclerosis, epilepsy, porphyria, tetany,
Hepatotoxicity, anaemia, myocardial ischaemia, Pregnancy, lactation, severe disturbances of
chorea minor, history of phlebitis. Benign and rarely,
oedema, thromboembolic disease, headache, liver function, history of idiopathic jaundice or Barbiturates, phenylbutazone, hydantoins,
malignant liver tumours which may lead to life
Cyproterone Acetate 2 mg & 1 tablet daily for 21 days from the first day of the cycle, gastric upsets, nausea, breast tension, changes severe pruritus during pregnancy, previous or rifampicin and ampicillin may impair the action of
Diane 35 Androgen dependent diseases in women threatening intra abdominal haemorrhage have been
Ethinyloestradiol 0.035 mg Tablet followed by 7 tab free days in body weight and libido, intermenstrual existing liver tumours, malignant diseases (not the drug. Requirements for oral antidiabetics and
observed. If severe upper abdominal complaints,
bleeding, depressive mood, chloasma, fluid prostatic carcinoma), thromboembolic disorders, insulin can change
liver enlargement or signs of intra abdominal
retention acute liver disease, hypersensitivity
haemorrhage occur, a liver tumour should be taken
into consideration
i) After orchidectomy, 100 mg once daily or twice daily

ii) If used together with LHRH agonists, the initial dose Pregnancy, lactation, thromboembolic disorders,
Cyproterone Acetate 50 mg Tablet Androcur Carcinoma of prostate is 100 mg twice daily for 5 to 7 days before the start of Monitor liver function Tiredness, liver dysfunction, gynaecomastia liver disease, severe diabetes with vascular Oral antidiabetics, insulin
LHRH agonist, then 100 mg twice daily for 3 to 4 weeks changes
together with the LHRH agonist
Standard doses 100 - 200 mg/m2 daily over 5 - 10

Renal and hepatic impairment. Patients over 50
i) Central nervous system lymphoma ii) Meningeal days. Higher doses for intensification/consolidation:
years old (for high dose therapy), pregnancy and
leukemia iii) Non Hodgkin's Lymphoma iv) High dose 1000 - 3000 mg/m2 daily over 3 - 5 days depending on
lactation. Pre-existing drug-induced bone marrow Myelosuppression, alopecia, fever, mucositis, Increased cytotoxicity when radiotherapy,
cytarabine as conditioning to cytoreduce the disease specific protocols. CHILD: Dose variable depending on
suppression, leukocyte and platelet counts should nausea and vomiting, rash, neurotoxicity, alkylating agents, methotrexate and purine
before stem cell transplant for relapsed or refractory disease and protocol. Range from 100 mg/m2 to 3 g/m2 Hypersensitivity to cytarabine products.
Cytarabine 1 g Injection Cytosar be monitored daily, bone marrow examinations headache, dizziness, somnolence, photophobia, analogues are given together with cytarabine.
leukemia v) As salvage for acute lymphocytic leukemia twice daily. May be given as SC, IV bolus or infusion. Pregnancy, lactation
should be performed periodically, hepatic cerebellar toxicity, pneumonitis, pulmonary Increased ototoxicity if used concurrently with
vi) As salvage for acute myeloid leukemia vii) As Intrathecal dose: Less than 1 year: 15 mg, 1 - 2 years:
impairment, women of childbearing age, infants, oedema, conjunctivitis, hepatic dysfunction cisplatin
palliative chemotherapy in elderly acute myeloid 20 mg, 2 - 3 years: 25 mg, more than 3 years: 30 mg.
severe gastrointestinal, central nervous system and
leukemia/ myelodysplastic syndrome (ENSURE THAT PREPARATION IS SUITABLE FOR
pulmonary toxicity when using high dose schedules
INTRATHECAL USE)
Cytarabine 100 mg Injection Cytosar be monitored daily, bone marrow examinations headache, dizziness, somnolence, photophobia, analogues are given together with cytarabine.
INTRATHECAL USE)
Cytarabine 500 mg Injection Cytosar be monitored daily, bone marrow examinations headache, dizziness, somnolence, photophobia, analogues are given together with cytarabine.
INTRATHECAL USE)
Following total knee replacement: Initially ADULT

110mg (ELDERLY, 75 mg) within 1- 4 hours after Heparins, fondaparinux, desirudin, thrombolytic
Severe renal and hepatic impairment, active
Prevention of venous thromboembolic events in surgery, then 220 mg (ELDERLY, 150 mg) once daily Patients at risk for bleeding, recent biopsy or major Bleeding, anaemia, haematoma, haemorrhage, agents, GPIIb/IIIa receptor antagonists,
bleeding, organic lesion at risk of bleeding,
Dabigatran Etexilate 110 mg Capsule Pradaxa patients who have undergone total knee replacement thereafter for 6-10 days Following total hip replacement: trauma, spinal & epidural anaesthesia, lumbar haematuria, decreased haemoglobin, wound clopidogrel, ticlopidine, dextran, sulfinpyrazone,
concomitant treatment with quinidine, pregnancy
or total hip replacement surgery Initially ADULT 110 mg (ELDERLY, 75 mg) within 1- 4 puncture, pregnancy & lactation, children secretion, post-procedural discharge vitamin K antagonists, amiodarone, quinidine,
and lactation
hours after surgery, then 220 mg (ELDERLY, 150 mg) NSAIDs, sibutramine
once daily thereafter for 28-35 days
Following total knee replacement: Initially ADULT 110

mg (ELDERLY, 75 mg) within 1- 4 hours after surgery, Heparins, fondaparinux, desirudin, thrombolytic
Severe renal and hepatic impairment, active
Prevention of venous thromboembolic events in then 220 mg (ELDERLY, 150 mg) once daily thereafter Patients at risk for bleeding, recent biopsy or major Bleeding, anaemia, haematoma, haemorrhage, agents, GPIIb/IIIa receptor antagonists,
bleeding, organic lesion at risk of bleeding,
Dabigatran Etexilate 75 mg Capsule Pradaxa patients who have undergone total knee replacement for 6-10 days Following total hip replacement: Initially trauma, spinal & epidural anaesthesia, lumbar haematuria, decreased haemoglobin, wound clopidogrel, ticlopidine, dextran, sulfinpyrazone,
concomitant treatment with quinidine, pregnancy
or total hip replacement surgery ADULT 110 mg (ELDERLY, 75 mg) within 1- 4 hours puncture, pregnancy & lactation, children secretion, post-procedural discharge vitamin K antagonists, amiodarone, quinidine,
and lactation
after surgery, then 220 mg (ELDERLY, 150 mg) once NSAIDs, sibutramine
daily thereafter for 28-35 days
Nausea, vomiting, myelosuppression, flu-like
Drugs that induce hepatic P450 enzymes (eg
i) Malignant melanoma, sarcomas, neuroblastomas symptoms, alopecia, rash, photosensitivity,
i) 250 mg/m2 for 5 days, may be repeated every 3 Renal or hepatic impairment, bone marrow Hypersensitivity to dacarbazine products, phenobarbital, phenytoin) may lead to decreased
Dacarbazine 100 mg Injection - and other childhood solid tumours ii) Hodgkin's vesicant, paresthesias, ataxia, lethargy,
weeks ii) 375 mg/m2 IV every 2 weeks depression. Pregnancy. Avoid extravasation pregnancy, lactation efficacy. Increased risk of infection by the live
Disease headache, confusion, seizures, anaphylactic
vaccine
reactions, elevation of liver enzymes
Co-administration of oral anticoagulants has

resulted in a prolonged prothrombin time and
haemorrhages. Carbamazepine : significant
Haemophilia, epilepsy, migraine or cardiac or renal increases in carbamazepine levels which
i)200 - 800 mg daily for max of 9 months ii)200 mg daily
i)Endometriosis and gynaecomastia ii)Menorrhagia dysfunction, require careful observation. Periodic Hepatic dysfunction, weight gain, acne, Undiagnosed abnormal vaginal bleeding, hepatic resulted in toxicity. Clomifene : result in inhibition
Danazol 100 mg Capsule Ladogal for 12 weeks ii)400 mg daily. Reduce to 200 mg daily
iii)Prophylaxis of hereditary angioedema liver function tests should be performed, menstrual disturbances or renal or cardiac dysfunction of response to clomifene. Cyclosporin :
after 2 months attack free period
exacerbation of acute intermittent porphyria increased cyclosporin blood levels and toxicity.
Sirolimus, Tacrolimus : decrease the
metabolism, causing increased plasma
concentrations of sirolimus and tacrolimus
Co-administration of oral anticoagulants has
resulted in a prolonged prothrombin time and
haemorrhages. Carbamazepine : significant
Haemophilia, epilepsy, migraine or cardiac or renal increases in carbamazepine levels which
i)200 - 800 mg daily for max of 9 months ii)200 mg daily
i)Endometriosis and gynaecomastia ii)Menorrhagia dysfunction, require careful observation. Periodic Hepatic dysfunction, weight gain, acne, Undiagnosed abnormal vaginal bleeding, hepatic resulted in toxicity. Clomifene : result in inhibition
Danazol 200 mg Capsule Ladogal for 12 weeks ii)400 mg daily. Reduce to 200 mg daily
iii)Prophylaxis of hereditary angioedema liver function tests should be performed, menstrual disturbances or renal or cardiac dysfunction of response to clomifene. Cyclosporin :
after 2 months attack free period
exacerbation of acute intermittent porphyria increased cyclosporin blood levels and toxicity.
Sirolimus, Tacrolimus : decrease the
metabolism, causing increased plasma
concentrations of sirolimus and tacrolimus
Nausea, vomiting, anorexia; fever, malaise,

Rifampicin increases plasma clearance of
i) ADULT: 6 - 10 mg/kg weekly (around 50 - 100 mg headache; dizziness, tachycardia, nervousness,
Cardiac, pulmonary, hepatic or renal disease, Hypersensitivity to dapsone products, severe dapsone. Excretion decreased by probenecid.
Dapsone 100 mg Tablet - i)Leprosy ii) Dermatitis herpetiformis daily). CHILD: 1 - 2 mg/kg/day. Maximum: 100 mg/day insomnia, skin disorders, agranulocytosis,
pregnancy, lactation anaemia, G6PD deficiency Pyrimethamine may increase the likelihood of
ii) ADULT: 50 - 300 mg daily peripheral neuritis, psychosis, haemolysis,
haematologic reactions
methaemoglobinemia; hypersensitivity reactions
i) 45 - 60 mg/m2 IV daily for 3 - 5 days ii) 25 - 45 mg/m2

once a week for first 4 weeks during induction phase.
Alopecia, radiation recall reactions. Hypersensitivity to daunorubicin. Pregnancy,
Caution: Total cumulative dose of daunorubicin and
Hyperpigmentation of nails. Myelosuppression. lactation, pre-existing myelosupression,
i) Acute myeloblastic leukaemia (AML) ii) Acute doxorubicin must not exceed 500 mg/m2 due to risk of Hepatic impairment. Previous radiotherapy to chest. Increased risk of infection by live vaccines,
Daunorubicin HCl 20 mg Injection Cerubidin Nausea, vomiting, mucositis, diarrhoea, congestive cardiac failure, arrhythmias or
lymphoblastic leukemia (ALL) cardiotoxicity. CHILD: 30-45 mg/m2/dose infusion over Avoid extravasation azidamfenicol, chloramphenicol, ciclosporin
hepatic/renal impairment, discolouration of urine. previous treatment with high cumulative doses of
6 hours. Schedule depends on protocol. Need to check
ECG abnormalities, congestive cardiac failure anthracyclines
cardiac function closely by echocardiography every
cumulative dose of 100mg/m2 to max. 360 mg/m2
Rash, urticaria, abdominal pain, diarrhoea,
Increased risk of potentially fatal acute renal failure, nausea, vomiting, backache, headache, cough,
concomitant use of medicines that depress renal bronchitis, fever, influenza, cytopenia, drug-
Treatment of chronic iron overload due to blood Initial 20 mg/kg/day. Starting dose can also be based
Deferasirox 125 mg Dispersible function, elderly, haematologic disorders (including induced hepatitis, increased liver enzyme, Hypersensitivity to deferasirox or to any
Exjade transfusions (transfusional haemosiderosis) in adult on transfusion rate and existing iron burden. Max is 30 Aluminium containing antacids
Tablet neutropenia, thrombocytopenia and anaphylaxis, hypersensitivity disorder, arthralgia, component of the product
and pediatric patients aged 2 years and above mg/kg/day
agranulocytosis), acute renal failure with advanced- cataract, retinal disorder, raised intraocular
stage disorders renal conditions pressure, hearing loss, infection of ear, fatigue,
acute renal failure
Rash, urticaria, abdominal pain, diarrhoea,
Increased risk of potentially fatal acute renal failure, nausea, vomiting, backache, headache, cough,
concomitant use of medicines that depress renal bronchitis, fever, influenza, cytopenia, drug-
Treatment of chronic iron overload due to blood Initial 20 mg/kg/day. Starting dose can also be based
Deferasirox 500 mg Dispersible function, elderly, haematologic disorders (including induced hepatitis, increased liver enzyme, Hypersensitivity to deferasirox or to any
Exjade transfusions (transfusional haemosiderosis) in adult on transfusion rate and existing iron burden. Max is 30 Aluminium containing antacids
Tablet neutropenia, thrombocytopenia and anaphylaxis, hypersensitivity disorder, arthralgia, component of the product
and pediatric patients aged 2 years and above mg/kg/day
agranulocytosis), acute renal failure with advanced- cataract, retinal disorder, raised intraocular
stage disorders renal conditions pressure, hearing loss, infection of ear, fatigue,
acute renal failure
Treatment of iron overload in patients with thalassemia Genotoxicity, neutropenia, agranulocytosis,
In case of persistent arthropathy, deferiprone Aluminium containing antacids. Due to the risk of
major for whom desferrioxamine therapy is tachycardia, vasculitis, weight gain, zinc
25 mg/kg 3 times a day for total daily dose of 75 mg/kg. therapy should be discontinued. Monitor neutrophil Severe liver dysfunction, existing neutropenia, additive toxicity, use with drugs that may cause
Deferiprone 500 mg Tablet Ferriprox contraindicated or inadequate. Add on therapy to deficiency, abdominal pain, urine discoloration,
Doses greater 100 mg/kg are not recommended counts weekly. Interrupt therapy if patient develops agranulocytosis, pregnancy and lactation neutropenia or agranulocytosis is not
desferrioxamine for thalassemia patients with cardiac hepatotoxicity, visual impairment, joint problems,
an infection recommended
complication ototoxicity and skin rash
Tachycardia, mild to moderate hypotension,
elevated blood pressure, extrapyramidal
Concomitant administration of other central nervous Central nervous system depressants (eg.
symptoms, postoperative drowsiness. Dry
system depressants; elderly, debilitated, or poor-risk Antidepressants, barbiturates) have additive or
mouth, constipation, micturition difficulty, blurred
patients require reduced dosages; high doses in potentiating central nervous system effects with
vision, mydriasis, delirium, agitation, catatonic- Hypersensitivity to Droperidol. Coma; central
patients at risk for cardiac dysrhythmia; impaired droperidol. Avoid concurrent use with drugs that
1-10 mg 30 minutes before chemotherapy followed by like states, insomnia, nightmares, depression, nervous system depression;
hepatic or renal function; hypotension; EEG pattern may prolong QT interval e.g. certain
Dehydrobenzperidol 2.5 mg/ml continuos 1 to 3 mg/hour or 1 to 5 mg IM or IV injection miosis, convulsions, nasal congestion. pheochromocytoma; bone marrow suppression.
Droperidol Chemotherapy Induced Nausea or Vomiting. may slowly return to normal. History of jaundice; antihistamines, antimalarials, calcium-channel
Injection every 1-6 hours as necessary. CHILD: 0.1 mg/kg/dose cardiovascular effects; hypersensitivity reactions, Patients at risk of arrhythmias, CV disorders,
diabetes mellitus; hyperthyroidism; Parkinson's blockers and antidepressants. May potentiate
IV slowly 4 - 6 hourly haematological disorders, extrapyramidal electrolyte imbalance, preexisting QT
disease; epilepsy, depression, myasthenia gravis; the action of other CNS depressants e.g.
dysfunction. Amenorrhoea, galactorrhoea, prolongation
prostatic hypertrophy; severe respiratory disease; barbiturates, alcohol. Caution when using with
gynaecomastia, weight gain and
blood dyscrasias. May precipitate coma, affect drugs that may induce hypokalaemia or
hyperglycaemia, and altered glucose tolerance.
driving. Pregnancy; lactation hypomagnesemia
Pain and irritation at the Injection site. post-op
drowsiness
Safety and effectiveness have not been established

in children under the age of 3 years, vision or
i) 2 g by IM immediately and 5 g by mouth after gastric auditory problem. Concomitant vitamin C with
Thrombocytopenia, hypotension, tachycardia,
i) Acute iron poisoning in children ii) Investigation and lavage ii) 0.5 - 1.5 g by IM injection daily iii) Diagnosis: desferrioxamine in patients with severe chronic iron
flushing, rash, anaphylactic reaction, disturbance
Desferrioxamine B treatment of haemochromatosis iii) Diagnosis and 5 mg per kg by slow intravenous infusion during the last overload or cardiac failure, high doses and
Desferal of vision and hearing, vomiting, diarrhoea, shock, Anuria or severe renal disease Ascorbic acid, phenothiazines
Methanesulphonate 0.5 g Injection treatment of aluminium toxicity in patients with renal hour of haemodialysis. Treatment: 5 mg per kg once a concomitant low ferritin levels have been associated
tachyarrhythmia, ototoxicity (frequent), mycosis
failure and dialysis iv) Chronic iron toxicity or overload week by slow intravenous infusion during the last hour with growth retardation, increased susceptibility to
(rare)
of dialysis iv) 30 - 50 mg/kg Yersinia enterocolitica, Yersinia pseudotuberculosis,
mucormycosis, patients with aluminum overload or
aluminum-related encephalopathy
Patients with respiratory, renal or hepatic
impairment. Elderly or obese patients. May impair
ability to drive or operate machinery. Concomitant
use with adrenaline or other sympathomimetics.
ADULT: Induction , initially 3% in oxygen or nitrous Pregnancy and lactation. Patient with ccoronary Enhanced effects of neuromuscular blockers;
oxide/oxygen and increased by 0.5%-1% every 2-3 heart disease or where increase in heart rate or BP Dose-dependent hypotension and respiratory CNS depressants. Lower dose is required when
Patient in whom general anaesthesia is
breaths or as tolerated (up to 11%), until loss of is undesirable - use together with other medication depression. Cough, breath holding, salivation, used with opioids, benzodiazepines and other
i) Induction and maintenance of anaesthesia in adult ii) contraindicated. Sensitivity to halogenated
Desflurane Liquid Suprane consciousness. Maintenance: 2.5%-8.5% with or (eg IV opioid, hypnotics). Causes increase in apnoea and laryngospasm. Post-operation sedatives. Enhanced hypotensive effects of ACE
Maintenance of anaesthesia in infants & children agents. Genetic susceptibility to malignant
without concomitant nitrous oxide CHILD: maintenance, cerebrospinal fluid or intracranial pressure in patient nausea & vomiting. Transient increase of white inhibitors, tricyclic antidepressants (TCAs),
hyperthermia.
inhaled in concentrations of 5.2%-10% with or without with space occupying lesions. Discontinue use if blood cells count, malignant hyperthermia. MAOIs, antihypertensives, antipsychotics, beta-
concomitant nitrous oxide malignant hyperthermia occurs. Can react with blockers.
dessicated CO2 absorbents to produce CO which
may result in increased levels of
carboxyhaemoglobin. Pregnancy, lactation, childn
less than 12 year
ADULT & CHILD more than 12 years : 5 mg once daily. Phenylketonuric patient, severe renal or hepatic
Amphetamines, alcohol, betahistine, CNS
Desloratadine 5 mg Tablet Aerius Allergic rhinitis and chronic idiopathic urticaria CHILD: 6-11 yr: 2.5 mg; 1-5 yr: 1.25 mg; 6-11 mth: 1 failure; children less than 6 month, elderly, epilepsy, Fatigue, headache and dry mouth Hypersensitivity to desloratadine or loratadine
depressants, acetylcholinesterase Inhibitors
mg. Doses to be taken once daily preg-nancy and lactation
i)ADULT and CHILD: 0.1 mg 3 times daily.
Avoid fluid overload in the very young & the elderly,
Maintenance: 0.3-0.6 mg daily ii)ADULT and CHILD Nausea, hypertension, hypotension, palpitation,
i)Central diabetes insipidus ii)Primary nocturnal conditions characterised by fluid & or electrolyte Hypersensitivity to desmopressin; hyponatremia
over 5 years, 0.2 mg at bed time; withdraw for 1 week anaphylaxis, transient headache, stomach pain, Chlorpropamide, fludrocortisone, lithium,
Desmopressin 0.1 mg Tablet Minirin enuresis iii)Treatment of nocturia associated with imbalance & those at risk for increased intracranial or a history of hyponatremia; moderate-to-severe
for assessment after 3 months iii)Initially 0.1 mg at epistaxis , fatigue, transient fall in BP with reflex carbamazepine , chloropromazine, indomethacin
nocturnal polyuria in adult pressure. Caution in renal concentration capacity renal impairment
night. May be increased to 0.2 mg and then to 0.4 mg tachycardia and facial flushing
testing for children less than 1 year
by means of weekly increase
i)ADULT and CHILD: 0.1 mg 3 times daily.
Avoid fluid overload in the very young & the elderly,
Maintenance: 0.3-0.6 mg daily ii)ADULT and CHILD Nausea, hypertension, hypotension, palpitation,
i)Central diabetes insipidus ii)Primary nocturnal conditions characterised by fluid & or electrolyte Hypersensitivity to desmopressin; hyponatremia
over 5 years, 0.2 mg at bed time; withdraw for 1 week anaphylaxis, transient headache, stomach pain, Chlorpropamide, fludrocortisone, lithium,
Desmopressin 0.2 mg Tablet Minirin enuresis iii)Treatment of nocturia associated with imbalance & those at risk for increased intracranial or a history of hyponatremia; moderate-to-severe
for assessment after 3 months iii)Initially 0.1 mg at epistaxis , fatigue, transient fall in BP with reflex carbamazepine , chloropromazine, indomethacin
nocturnal polyuria in adult pressure. Caution in renal concentration capacity renal impairment
night. May be increased to 0.2 mg and then to 0.4 mg tachycardia and facial flushing
testing for children less than 1 year
by means of weekly increase
Avoid fluid overload in the very young and the Nausea, hypertension, hypotension, palpitation, Hypersensitivity to desmopressin, hyponatremia
elderly, conditions characterized by fluid and or anaphylaxis, transient headache, stomach pain, or a history of hyponatremia, moderate-to-severe
Desmopressin 100 mcg/ml Nasal i) ADULT : 10 - 20 mcg 1-2 times daily. CHILD: 5 - Chlorpropamide, fludrocortisone, lithium,
Minirin i) Diabetes Insipidus ii) Primary nocturnal enuresis electrolyte imbalance and those at risk for increased epistaxis and fatigue, transient fall in blood renal impairment , unstable angina pectoris,
Spray 10mcg 1-2 times daily ii) 10-40 mcg carbamazepine, chloropromazine, indomethacin
intracranial pressure. Caution in renal concentration pressure with reflex tachycardia and facial decompensated cardiac insufficiency and von
capacity testing for infant less than 1 year flushing Willebrand's disease type IIB
Avoid fluid overload in the very young and the
elderly, conditions characterized by fluid and or Nausea, hypertension, hypotension, palpitation, Hypersensitivity to desmopressin , hyponatremia
electrolyte imbalance and those at risk for increased anaphylaxis, transient headache, stomach pain, or a history of hyponatremia , moderate-to-
Desmopressin Acetate 4 mcg/ml i) Diabetes insipidus ii) Haemostasis in peri-operative i) ADULT : 1 - 4 mcg IV daily. CHILD :0.4 mcg daily ii) Chlorpropamide, fludrocortisone, lithium,
Minirin intracranial pressure. Caution in renal concentration epistaxis and fatigue, transient fall in blood severe renal impairment , unstable angina
Injection situations 0.3 mcg/kg IV carbamazepine, chloropromazine, indomethacin
capacity testing for infant less than 1 year. In pressure with reflex tachycardia and facial pectoris , decompensated cardiac insufficiency
hemostatic use, avoid fluid overload in patient taking flushing and von Willebrand's disease type IIB
diuretics
Gastrointestinal disease (impaired absorption of oral
contraceptive steroids in the small bowel due to
Thromboembolic disorders, coronary artery Irregular bleeding and reduced efficacy with
inflammatory disease, diarrhoea, ileostomy or
disease, breast or endometrial cancer, oestrogen anticonvulsant, barbiturates, tetracyclines,
1 tablet daily for 21 days, subsequent courses repeated jejunoileal bypass may result in contraceptive
Desogestrol 150 mcg & Thromboembolic disease, hypertension, gall dependent neoplasia, undiagnosed abnormal rifampicin, activated charcoal, certain laxatives,
Marvelon Contraception after 7 day interval (during which withdrawal bleeding failure). Severe varicose veins, hepatic cell
Ethinyloestradiol 30 mcg Tablet bladder disease, nausea, vomiting, migraine vaginal bleeding, cholestatic jaundice of antidiabetic drugs. Monitor patients receiving
occurs) adenoma, latent or overt cardiac failure, renal
pregnancy, hepatic adenomas or carcinomas, alprazolam therapy for an increased response to
dysfunction, epilepsy, migraine, hypertension,
known or suspected pregnancy the benzodiazepine
diabetes, smoking, surgery or prolonged
immobilization
Barbiturates, phenytoin, rifampin may decreases
dexamethasone effects; dexamethasone
Croup, septic shock, cerebral oedema and respiratory 0.5 - 9 mg daily, depending upon the disease being Discontinue treatment by reducing the dosage Fluid and electrolyte disturbances, muscle decreases effect of salicylates, vaccines,
Dexamethasone 0.5 mg Tablet Decadron Hypersensitivity, systemic fungal infection
distress syndrome including status asthmaticus treated. Up to 15 mg daily in severe disease gradually weakness, peptic ulcer toxoids. Increased effect: Salmeterol: The
addition of salmeterol has been demonstrated to
improve response
Burning and stinging or local irritation may occur.
Dexamethasone and Neomycin
Treatment of ocular inflammation when concurrent use Apply 1 - 1.5 cm 3 - 4 times daily, may be used Glaucoma, corneal or scleral thinning, history of HSV Hypersensitivity (due to neomycin content). Hypersensitivity to its component, viral, fungal,
Sulphate and Polymyxin B Eye Maxitrol Not known
of an antimicrobial is judged necessary adjunctively with drops at bedtime infection Ocular itching, reddening, conjunctival oedema, tuberculosis and other infections of the eye
Ointment
rash or persistent irritation, periorbital oedema

Dexamethasone and Neomycin
Treatment of ocular inflammation when concurrent use 1 - 2 drops hourly for severe cases and 4 - 6 hourly for Glaucoma, corneal or scleral thinning, history of HSV Hypersensitivity (due to neomycin content). Hypersensitivity to its component, viral, fungal,
Sulphate and Polymyxin B Sulphate Maxitrol Not known
of an antimicrobial is judged necessary mild infection infection Ocular itching, reddening, conjunctival oedema, tuberculosis and other infections of the eye
Ophthalmic Suspension
rash or persistent irritation, periorbital oedema
Prolonged use may lead to posterior subcapsular
thinning of the cornea and sclera. Burning, dry
Dexamethasone Sodium Phosphate Acute steroid responsive inflammatory and allergic cataract formation and glaucoma with raised optic- Viral, fungal, tuberculosis and other infections of
Maxidex 1 - 2 drops 4 - 6 times a day eyes, photophobia, glaucoma, elevated Not known
0.1% Eye Drops conditions ocular pressure. Pregnancy. Extensive use may lead the eye. Hypersensitivity to dexamethasone
intraocular pressure, optic nerve damage,
to systemic effects
cataract
Barbiturates, phenytoin, rifampicin may decrease
dexamethasone effects; dexamethasone
During periods of stress. Mask the signs of infection
Dexamethasone Sodium Phosphate 8 Croup, septic shock, cerebral oedema and respiratory Initially 0.5 - 9 mg IM, IV or infusion daily, depending Fluid and electrolyte disturbances, muscle decreases effect of salicylates, vaccines,
Decadron and decrease resistance to infection. Discontinue Hypersensitivity. systemic fungal infections
mg/2 ml Injection distress syndrome including status asthmaticus upon the disease being treated weakness, peptic ulcer toxoids. Increased effect: Salmeterol: The
treatment by reducing the dosage gradually
addition of salmeterol has been demonstrated to
improve response
Narrow-angle glaucoma, stenosing peptic ulcer,
bladder neck obstruction, bronchial asthma,
Actions prolonged by MAOIs, alcohol, tricyclic
Dexchlorpheniramine Maleate 2 mg Symptomatic treatment of allergic rhinitis and allergic ADULT : 2 mg 3 times daily. CHILD : 1 - 12 years : 2 symptomatic prostatic hypertrophy, pyloroduodenal Drowsiness, urticaria, dry mouth, gastrointestinal Hypersensitivity to dexchlorpheniramine
Polaramine antidepressant, barbiturates. Other CNS
Tablet dermatoses mg 3 times daily obstruction, cardiovascular diseases, disturbances, somnolence, nasal mucosa dry products
depressants can potentiate effects
hyperthyroidism, avoid driving and operating
machinery
Dexchlorpheniramine Maleate 2 mg/5 CHILD 2 - 5 years : 0.5 mg every 4 - 6 hours; 6 - 11 symptomatic prostatic hypertrophy, pyloroduodenal Drowsiness, urticaria, dry mouth, gastrointestinal Hypersensitivity to dexchlorpheniramine
Polaramine Symptomatic treatment of allergic rhinitis antidepressant, barbiturates. Other CNS
ml Syrup years : 1 mg every 4 - 6 hours obstruction, cardiovascular diseases, disturbances, somnolence, nasal mucosa dry products
machinery
Dexchlorpheniramine Maleate 6 mg symptomatic prostatic hypertrophy, pyloroduodenal Drowsiness, urticaria, dry mouth, gastrointestinal Hypersensitivity to dexchlorpheniramine
Polaramine Symptomatic treatment of allergic rhinitis ADULT : 1 repetab 2 times daily antidepressant, barbiturates. Other CNS
Tablet obstruction, cardiovascular diseases, disturbances, somnolence, nasal mucosa dry products
machinery
Significant cardiovascular dysfunction, advanced
Not to be infused for more than 24 hours, 1 mcg/kg Hypotension (more frequent), hypertension,
Dexmedetomidine HCl 100 mcg/ml Sedation of intubated and mechanically ventilated ICU heart block, renal and hepatic impairment, elderly Enhances effects of anaesthesia, sedative,
Precedex over 10 minutes as loading dose. Maintenance dose: cardiovascular disease, nausea, dry mouth, Hypersensitivity to dexmedetomidine
Injection patients. For use only by specialist anaesthetist more than 65 years, pregnancy, lactation, diabetes hypnotics and other CNS depressants, opiods
0.2 - 0.7 mcg/kg/hr hypoxia, somnolence
mellitus, chronic hypertension
Cardiac disease, liver disease and renal impairment,
Hypersensitivity to dextran or corn products,
Condition associated with peripheral local slowing of bowel surgery, decreased urinary output secondary Acute renal failure, anaphylaxis, congestive Abciximab, tinzaparin. May interfere with blood
Initially 500-1000 ml by infusion, further doses are pulmonary oedema, renal disease with severe
Dextran 40 Dextran 40 the blood flow, prophylaxis of post surgical to shock, dehydration, active haemorrhage, heart failure, pulmonary edema, group cross-matching or biochemical
given according to the patient's condition oliguria or anuria, severe bleeding disorders,
thromboembolic disease hypernatremia, pathological abdominal conditions thrombocytopenia measurements
severe congestive heart failure
and thrombocytopenia
Do not use concentrated solutions of dextrose in
patients with anuria, diabetic coma,
Diabetes mellitus or carbohydrate intolerance and
hyperglycaemia, intracranial or intraspinal
hyperglycaemia may accentuate neurologic damage
For parenteral replenishment of fluid and minimal Thrombophlebitis, rebound hypoglycaemia, haemorrhage, delirium tremens in dehydrated
for an ischaemic insult. Patients at risk for cerebral
Dextrose 10% Injection - carbohydrate calories as required by the clinical According to the needs of the patient hypokalaemia, pulmonary embolism, right atrial patients and glucose-galactose malabsorption Not known
ischaemia, acute stroke, impending cardiac arrest or
condition of the patient thrombosis, extravasation syndrome. Do not administered simultaneously
severe hypotension unless hypoglycaemia is
with blood through the same infusion set
suggested or until glucose is determined
because of the possibility that
pseudoagglutination of red cells may occur
Diabetes mellitus or carbohydrate intolerance and Do not use concentrated solutions of dextrose in
hyperglycaemia may accentuate neurologic damage patients with anuria, diabetic coma and
for an ischemic insult, patients at risk for cerebral Thrombophlebitis, rebound hypoglycaemia, hyperglycaemia, intracranial or intraspinal
Dextrose Powder - Use as a diagnostic agent for diabetes 75 g stat Not known
ischemia, acute stroke, impending cardiac arrest, or hypokalaemia haemorrhage, delirium tremens in dehydrated
severe hypotension unless hypoglycaemia is patients and glucose-galactose malabsorption
suggested or until glucose is determined syndrome
i) ADULT and CHILD more than 10 year, ORALLY: 60 -
100 ml RECTALLY, contrast medium should be diluted
Nausea, vomiting and or diarrhoea, urticaria with
with 3-4 times its volume of water. ORALLY: CHILD
erythema, hypoxia, acute dyspnoea,
i) Contrast medium for the radiological examination of less than 10 years,: 15- 30 ml NEWBORN, INFANT
tachyarrhythmia and anaphylaxis have occurred
the gastrointestinal tract (primarily in cases in which contrast medium should be diluted with 3 times its
Diatrizoate Meglumine and Sodium Gastrografin Thyroid dysfunction, severe cardiovascular disease, following ingestion of the contrast medium, Manifest hyperthyroidism hypersensitivity to
barium sulphate is contraindicated) ii) Computerised volume of water. RECTALLY: CHILD more than 5 Beta blocker, interleukin
Amidotrizoate Solution Aqueous Solution very poor sate of health particularly when high concentrations of large diatrizoic acid salts
tomography in abdominal region iii) Treatment of years, contrast medium should be diluted with 4-5 times
volumes of solution are administered. Severe
Mecolinium ileus its volume of water. Younger patients a dilution with 5
changes in serum osmolarity and electrolyte
times its volume is recommended ii) Adult, orally, 25-77
concentrations may produce shock-like states
mL in 1000 mL tap water 15-30 minutes prior to
imaging
i) Status epilepticus, by slow IV: 5-10 every 10-15
minute (rate not more than 5 mg/min), to a total dose of
Drowsiness, dizziness, vertigo, hallucinations,
30 mg, may repeat in 2 hour if needed. Infants 30 days
blurred vision, confusion, muscle weakness,
to 5 years, 0.05-0.3 mg/kg/dose given over 2-3
fatigue, incontinence or urinary retention,
minutes, every 15-30 minutes to a total dose of 5 mg,
constipation, rashes, changes in libido, Respiratory depression, acute pulmonary
repeat in 2-4 hours if necessary. CHILD more than 5
Respiratory disease, history of drug or alcohol leukopenia and gastrointestinal, hypotension, insufficiency, severe hepatic impairment, acute Central nervous system depressants,
years, 1 mg by slow IV, every 2-5 minutes, maximum
i) Status epilepticus ii) Skeletal muscle spasm iii) abuse, drug dependence, pregnancy, breast ataxia, respiratory depression, sedation, narrow angle glaucoma, myasthenia gravis, barbiturates, alcohol, isoniazid, rifampicin,
Diazepam 10 mg/2 ml Injection Valium 10 mg, repeat in 2-4 hours if necessary ii) Skeletal
Anxiety disorders feeding, renal and hepatic impairment and avoid depression, headache, nausea, tremor, hypersensitivity to diazepam products, patients phenytoin, ritonavir, omeprazole, cimetidine,
muscle spasm, by slow IV or IM, 5-10 mg repeated if
operating vehicles or machinery withdrawal syndrome, neutropenia, less than 6 months old, alcohol intoxication, theophylline, digoxin, erythromycin, itraconazole
necessary in 3-4 hours. CHILD (tetanus): 30 days - 5
hepatotoxicity, pancytopenia, thrombocytopenia, central nervous system depression
years, 1-2 mg IM or IV slowly every 3-4 hours as
blood dyscrasias, bradycardia,
needed. 5 years and above, 5-10 mg IM or IV slowly
dependence/abuse. Paradoxical reactions in
every 3-4 hours if needed iii) Anxiety disorders, 2-10
children and elderly
mg by slow IV (not more than 5 mg/min). Repeat if
necessary every 3-4 hours
fatigue, incontinence or urinary retention, Respiratory depression, acute pulmonary
Erythromycin, clarithromycin, isoniazid, fentanyl,
i) ADULT: 2-10 mg 3-4 times daily. CHILD 6 months Respiratory disease, history of drug or alcohol constipation, rashes, changes in libido, insufficiency, severe hepatic impairment, acute
alfentanil, itraconazole, ketoconazole, digoxin,
and older: 0.12 - 0.8 mg/kg daily in divided doses, abuse, drug dependence, pregnancy, breast leukopenia and gastrointestinal, hypotension, narrow angle glaucoma and untreated open
phenytoin, rifampicin, ethanol, carbamazepine,
i) Muscle spasm of varied aetiology, including tetanus every 6-8 hours ii) ADULT : 2 mg 3 times daily, feeding, renal and hepatic impairment and avoid ataxia, respiratory depression, sedation, angle glaucoma, myasthenia gravis,
Diazepam 2 mg Tablet Valium phenobarbital, levodopa, lithium, amitriptyline,
ii) Anxiety disorders increased in severe anxiety to 15 - 30 mg daily in operating vehicles or machinery. Safety and depression, headache, nausea, tremor, hypersensitivity to diazepam products, patients
codeine, fluvoxamine, ginkgo, morphine,
divided doses. ELDERLY (or delibitated) half adult effectiveness not established in children less than 6 withdrawal syndrome, neutropenia, less than 6 months old, alcohol intoxication and
primidone, St John's Wort, theophylline,
dose. CHILD (night terrors), 1 - 5 mg at bedtime months of age hepatotoxicity, pancytopenia, thrombocytopenia, central nervous system depression. Pregnancy
thiopental
blood dyscrasias, bradycardia, and lactation
Status epilepticus - ADULT: 0.5 mg/kg repeated after
Respiratory disease, history of drug or alcohol blurred vision, confusion, muscle weakness,
12 hours if necessary. CHILD (febrile convulsions, Respiratory depression, acute pulmonary Central nervosu system depressants, alcohol,
abuse, drug dependence, pregnancy, breast fatigue, incontinence or urinary retention,
Diazepam 5 mg Rectal Solution Stesolid Status epilepticus, skeletal muscle spasm prolonged or recurrent): 0.5 mg/kg (maximum 10 mg), insufficiency, severe hepatic impairment, acute barbiturates, antibacterials, antivirals,
feeding, renal and hepatic impairment and avoid constipation, rashes, changes in libido,
repeated if necessary. Not recommended for children narrow angle glaucoma, myasthenia gravis omeprazole
operating vehicles or machinery leukopenia and gastrointestinal disturbances.
below 2 years
Paradoxical reactions in children and elderly
fatigue, incontinence or urinary retention, Respiratory depression, acute pulmonary
Erythromycin, clarithromycin, isoniazid, fentanyl,
i) ADULT: 2-10 mg 3-4 times daily. CHILD 6 months Respiratory disease, history of drug or alcohol constipation, rashes, changes in libido, insufficiency, severe hepatic impairment, acute
alfentanil, itraconazole, ketoconazole, digoxin,
and older: 0.12 - 0.8 mg/kg daily in divided doses, abuse, drug dependence, pregnancy, breast leukopenia and gastrointestinal, hypotension, narrow angle glaucoma and untreated open
phenytoin, rifampicin, ethanol, carbamazepine,
i) Muscle spasm of varied aetiology, including tetanus every 6-8 hours ii) ADULT : 2 mg 3 times daily, feeding, renal and hepatic impairment and avoid ataxia, respiratory depression, sedation, angle glaucoma, myasthenia gravis,
Diazepam 5 mg Tablet Valium phenobarbital, levodopa, lithium, amitriptyline,
ii) Anxiety disorders increased in severe anxiety to 15 - 30 mg daily in operating vehicles or machinery. Safety and depression, headache, nausea, tremor, hypersensitivity to diazepam products, patients
codeine, fluvoxamine, ginkgo, morphine,
divided doses. ELDERLY (or delibitated) half adult effectiveness not established in children less than 6 withdrawal syndrome, neutropenia, less than 6 months old, alcohol intoxication and
primidone, St John's Wort, theophylline,
dose. CHILD (night terrors), 1 - 5 mg at bedtime months of age hepatotoxicity, pancytopenia, thrombocytopenia, central nervous system depression. Pregnancy
thiopental
blood dyscrasias, bradycardia, and lactation
Do not apply to diseased skin or open wounds or
Post-traumatic inflammation of the tendons,ligaments & Allergic or non allergic contact dermatitis. Increase plasma concentration of lithium,
injuries. Avoid contact with eyes or mucous Hypersensitivity to diclofenac or other NSAIDs,
Diclofenac 1% Emulgel Voltaren joints. Localised forms of soft tissue rheumatism and Apply 3 - 4 times daily and gently rubbed in Generalized skin rash, hypersensitivity and methotrexate & warfarin. Reduces effects of
membranes. Systemic side effects when applied to proctitis and isopropanol or propylene glycol
degenerative rheumatism photosensitivity reactions diuretics & beta blockers
large areas of skin & over a prolonged period of time
Increases plasma concentration of warfarin,
lithium, & methotrexate. May reduce effects of
diuretics & beta blockers. May alter plasma
concentration of sulfonylureas. Caution with
Previous history of gastrointestinal ulceration, Patients with history of hypersensitivity to
concomitant use of diuretics and
bleeding or perforation. Renal dysfunction. diclofenac or aspirin/other NSAIDs. Peptic or
Diclofenac Sodium 12.5 mg Pain and inflammation in rheumatic disease and 75 - 150 mg daily in divided doses. CHILD 1-12 years, Occasionally gastrointestinal disorders, antihypertensives (eg beta-blockers, ACEI ),
Voltaren Hypertension or cardiac conditions aggravated by intestinal ulcer. Lactation. Use of suppository is
Suppository juvenile arthritis Juvenile arthritis; 12.5- 25 mg daily headache, dizziness, vertigo, rash, proctitis methotrexate, other NSAIDs and corticosteroids,
fluid retention and oedema. History of liver contraindicated in patients with recent rectal
SSRIs. Monitoring recommended for patients
dysfunction, coagulation defects bleeding
receiving anticoagulants, antiplatelets agents as
well as blood glucose level if used concomitantly
with antidiabetics. Digoxin, ciclosporin,
quinolones
Pain and inflammation in rheumatic disease and 75 - 150 mg daily in divided doses. CHILD 1-12 years, Occasionally gastrointestinal disorders, antihypertensives (eg beta-blockers, ACEI ),
Diclofenac Sodium 25 mg Suppository Voltaren Hypertension or cardiac conditions aggravated by intestinal ulcer. Lactation. Use of suppository is
juvenile arthritis Juvenile arthritis; 12.5- 25 mg daily headache, dizziness, vertigo, rash, proctitis methotrexate, other NSAIDs and corticosteroids,
quinolones
Pain and inflammation in rheumatic disease and 75 - 150 mg daily in divided doses. CHILD 1-12 years, Occasionally gastrointestinal disorders, antihypertensives (eg beta-blockers, ACEI ),
Diclofenac Sodium 50 mg Suppository Hypertension or cardiac conditions aggravated by intestinal ulcer. Lactation. Use of suppository is
juvenile arthritis Juvenile arthritis; 12.5- 25 mg daily headache, dizziness, vertigo, rash, proctitis methotrexate, other NSAIDs and corticosteroids,
quinolones
Previous history of gastrointestinal ulceration, Increases plasma concentration of warfarin,
ADULTS: Initial dose of 150 mg daily. Mild or long term:
bleeding, or perforation. Renal dysfunction. Hypersensitivity, rhinitis, urticaria, asthma or lithium and methotrexate. May reduce effects of
75 - 150 mg daily in 2 to 3 divided doses after food.
Diclofenac Sodium 50 mg Tablet Voltaren Pain and inflammation in rheumatic disease Hypertension or cardiac conditions aggravated by Epigastric pain, GI disturbances, slight dizziness allergic reactions to aspirin or other antidiuretics & beta blockers. May alter plasma
PAEDS 1 year and above : 1 - 3 mg/kg body weight
fluid retention and oedema. History of liver inflammatory agents concentration of sulfonylureas. Aspirin, warfarin,
daily
dysfunction, coagulation defects digoxin, methotrexate, ciclosporin
ACEI, angiotensin II antagonists, anticoagulants,
Pruritus, rash, contact dermatitis, pain, dry skin, cholestyramine and colestipol, ticlopidine,
Hypersensitivity to diclofenac or any component
Patient with CHF, dehydration, hypertension, exfoliation, paraesthesia, constipation, diarrhoea, aspirin. Monitoring recommended for patients
Diclofenac Sodium 75 mg/3 ml 75 mg once daily (2 times daily in severe cases) for not of the formulation, aspirin or other NSAIDs,
Voltaren Pain and inflammation in rheumatic disease decreased renal or hepatic function, active GIT headache, dizziness, vertigo, nausea, vomiting, receiving anticoagulants, antiplatelets agents as
Injection more than 2 days asthma, rhinitis, porphyria, pregnancy (third
ulceration or bleeding, pre-existing asthma gastrointestinal disorders, anorexia, increase well as blood glucose level if used concomitantly
trimester)
transaminases with antidiabetics. Lithium, digoxin, ciclosporin,
quinolones
Pancreatitis, peripheral neuropathy,
hepatomegaly, lactic acidosis, optic neuritis,
ADULT less than 60 kg: 125 mg twice daily or 250 mg retinal disorder, steatosis of liver, rash, pruritis, Allopurinol, ketoconazole, itraconazole, dapsone,
Peripheral neuropathy, history of pancreatitis, lactic
once daily; more than 60 kg: 400 mg once daily or 200 asthenia, headache, nausea, vomiting, ganciclovir/ valganciclovir, hydroxyurea,
Didanosine 100 mg Tablet (ddI) Videx HIV infection, in combination with other antiretrovirals acidosis, renal impairment, phenylketonuria, Hypersensitivity to didanosine
mg twice daily. CHILD more than 8 months: 120 mg/m2 abdominal pain, diarrhoea, chills, fever, pain, methadone, quinolone antibiotics, ribavirin,
pregnancy & lactation
twice daily, 2 weeks - 8 months: 100 mg/m2 twice daily retinal depigmentation, optic neuritis, anorexia, stavudine, tenofovir, ethanol
dyspepsia, flatulence, parotid gland enlargement,
arthralgia, myopathy
Pancreatitis, peripheral neuropathy, rash,

pruritis, asthenia, headache, nausea/vomiting,
ADULT less than 60 kg: 125 mg twice daily or 250 mg Allopurinol, ketoconazole, itraconazole, dapsone,
Peripheral neuropathy, history of pancreatitis, lactic abdominal pain, diarrhoea, chills, fever, pain,
once daily; more than 60 kg: 400 mg once daily or 200 ganciclovir / valganciclovir, hydroxyurea,
Didanosine 2 g Oral Solution (ddI) Videx HIV infection, in combination with other antiretrovirals acidosis, renal impairment, phenylketonuria, retinal depigmentation, optic neuritis, anorexia, Hypersensitivity to didanosine
mg twice daily. CHILD more than 8 months: 120 mg/m2 methadone, quinolone antibiotics, ribavirin,
pregnancy & lactation dyspepsia, flatulence, parotid gland enlargement,
twice daily, 2 weeks - 8 months: 100 mg/m2 twice daily stavudine, tenofovir, ethanol
anthralgia, myopathy, hypoglycaemia &
hyperglycaemia, rhabdomyolysis
ADULT less than 60 kg: 125 mg twice daily or 250mg retinal disorder, steatosis of liver, rash, pruritis, Allopurinol, ketoconazole, itraconazole, dapsone,
once daily; more than 60 kg: 400 mg once daily or 200 asthenia, headache, nausea, vomiting, ganciclovir/ valganciclovir, hydroxyurea,
Didanosine 25 mg Tablet (ddI) Videx HIV infection, in combination with other antiretrovirals acidosis, renal impairment, phenylketonuria, Hypersensitivity to didanosine
mg twice daily. CHILD more than 8 months: 120 mg/m2 abdominal pain, diarrhoea, chills, fever, pain, methadone, quinolone antibiotics, ribavirin,
twice daily, 2 weeks - 8 months: 100 mg/m2 twice daily retinal depigmentation, optic neuritis, anorexia, stavudine, tenofovir, ethanol
retinal disorder, steatosis of liver, rash, pruritis, Allopurinol, ketoconazole, itraconazole, dapsone,
Didanosine 250 mg Enteric Coated ADULT less than 60 kg: 250 mg once daily; 60 kg or asthenia, headache, nausea, vomiting, ganciclovir/valganciclovir, hydroxyurea,
Videx EC HIV infection, in combination with other antiretrovirals acidosis, renal impairment, phenylketonuria, Hypersensitivity to didanosine
Capsule greater: 400 mg once daily abdominal pain, diarrhoea, chills, fever, pain, methadone, quinolone antibiotics, ribavirin,
retinal depigmentation, optic neuritis, anorexia, stavudine, tenofovir, ethanol
retinal disorder, steatosis of liver, rash, pruritis, Allopurinol, ketoconazole, itraconazole, dapsone,
Didanosine 400 mg Enteric Coated ADULT less than 60 kg: 250 mg once daily; 60 kg or asthenia, headache, nausea, vomiting, ganciclovir/valganciclovir, hydroxyurea,
Videx EC HIV infection, in combination with other antiretrovirals acidosis, renal impairment, phenylketonuria, Hypersensitivity to didanosine
Capsule greater: 400 mg once daily abdominal pain, diarrhoea, chills, fever, pain, methadone, quinolone antibiotics, ribavirin,
retinal depigmentation, optic neuritis, anorexia, stavudine, tenofovir, ethanol
i) 1 mg/kg on the first day and increased gradually over Patients with onchocerciasis or Loa loa infestation,
Headache, lassitude, weakness, malaise,
3 days to 6 mg/kg daily in divided doses. This dosage is renal insufficiency. The toxicity of
Diethylcarbamazine Citrate 50 mg i) Bancrofti filariasis, onchocerciasis, loasis, creeping gastrointestinal upset, skin rash, allergic Hypersensitivity to diethylcarbamazine,
Hetrazan maintained for 21 days. ii) 13 mg/kg once daily for 7 Diethylcarbamazine may be increased in patients Not known
Tablet eruption ii) Ascariasis iii) Tropical eosinophilia reactions, dizziness, drowsiness, immunological pregnancy
days. CHILD : 6 - 10 mg/kg 3 times daily for 7 days iii) 6 with highly alkaline urine (eg, pH 7.5 to 8), renal
reaction, anorexia, encephalitis, dyspnea
mg/kg/day in 3 divided doses for 21 days impairment function, cardiac disorders
Acute myocardial infarction, acute myocarditis,

Nausea, vomiting, anorexia, diarrhoea,
Rapid digitalisation: 1-1.5 mg in divided doses over 24 amyloid cardiomyopathy, AV block. Chronic
abdominal pains, salivation, sweating; headache,
hours; less urgent digitalisation, 250 mcg-500 mcg daily constrictive pericarditis, electrolyte imbalance (eg. Plasma concentration increased by quinidine,
facial pain, malaise, fatigue, drowsiness, Ventricular fibrillation, ventricular tachycardia
(higher dose may be divided). Maintenance : 62.5mg - hypokalaemia, hypocalcaemia or hypercalcaemia, verapamil, nifedipine, amiodarone.
Heart failure , with atrial fibrillation, supraventricular depression, disorientation, mental confusion, except in certain cases, digitalis toxicity, beriberi
Digoxin 0.25 mg Tablet Lanoxin 500 mcg daily (higher dose may be divided) according hypomagnesaemia), hypothyroidism, hypoxia, Hypokalaemia may be associated with diuretics,
arrhythmias (particularly, atrial fibrillation) delirium, hallucination, visual heart disease, hypersensitivity to digoxin, some
to renal function and , in atrial fibrillation, on heart rate idiopathic hypertrophic subaortic stenosis. Renal lithium, carbenoxolone, corticosteroids. Antacids,
disturbance.Hypokalaemia. Ventricular cases of hypersensitive carotid sinus syndrome
response; usual range, 125-250 mcg daily (lower dose disease, severe bradycardia, severe heart failure neomycin may reduce serum level of digoxin
premature contractions, atrial or ventricular
may be appropriate in elderly) and pulmonary disease, ventricular tachycardia and
arrhythmias and conduction defects
Wolff-Parkinson-White syndrome
Rapid digitalization, give in divided doses; Acute myocardial infarction, acute myocarditis,
PREMATURE: 20-30 mcg/kg; FULLTERM: 25-35 amyloid cardiomyopathy, AV block. Chronic
abdominal pains, salivation, sweating; headache, Plasma concentration increased by quinidine,
mcg/kg; CHILD 1-2 years : 35 to 60 mcg/kg; CHILD 2-5 constrictive pericarditis, electrolyte imbalance (eg.
facial pain, malaise, fatigue, drowsiness, Ventricular fibrillation, ventricular tachycardia verapamil, nifedipine, amiodarone.
years: 30-40 mcg/kg; CHILD 5-10 years: 20- 35 hypokalaemia, hypocalcaemia or hypercalcaemia,
Heart failure, supraventricular arrhythmias (particularly depression, disorientation, mental confusion, except in certain cases, digitalis toxicity, beriberi Hypokalaemia may be associated with diuretics.
Digoxin 50 mcg/ml Elixir Lanoxin mcg/kg; CHILD over 10 years: 10-15 mcg/kg. For daily hypomagnesaemia), hypothyroidism, hypoxia,
atrial fibrillation) delirium, hallucination, visual heart disease, hypersensitivity to digoxin, some Antacids and neomycin may reduce serum level
maintenance doses or for gradual digitalization, give idiopathic hypertrophic subaortic stenosis. Renal
disturbance.Hypokalaemia.Ventricular premature cases of hypersensitive carotid sinus syndrome of digoxin. Lithium, carbenoxolone,
20% to 30% of oral digitalizing dose for premature disease, severe bradycardia, severe heart failure
contractions, atrial or ventricular arrhythmias and corticosteroids
infants or 25% to 35% of oral digitalizing dose for all and pulmonary disease, ventricular tachycardia and
conduction defects
other pediatric patients Wolff-Parkinson-White syndrome
amyloid cardiomyopathy, AV block. Chronic
abdominal pains, salivation, sweating; headache,
constrictive pericarditis, electrolyte imbalance (eg. Plasma concentration increased by quinidine,
facial pain, malaise, fatigue, drowsiness, Ventricular fibrillation, ventricular tachycardia
Rapid digitilisation: ADULT & CHILD over 10 years, hypokalaemia, hypocalcaemia or hypercalcaemia, verapamil, nifedipine, amiodarone.
Heart failure with atrial fibrillation, supraventricular depression, disorientation, mental confusion, except in certain cases, digitalis toxicity, beriberi
Digoxin 500 mcg/2 ml Injection Lanoxin initially 0.75 - 1.5 mg, followed by 250 mcg 6 hourly until hypomagnesaemia), hypothyroidism, hypoxia, Hypokalaemia may be associated with diuretics,
arrhythmias (particularly atrial fibrillation) delirium, hallucination, visual heart disease, hypersensitivity to digoxin, some
digitilisation is complete idiopathic hypertrophic subaortic stenosis. Renal lithium, carbenoxolone, corticosteroids. Antacids,
disturbance.Hypokalaemia.Ventricular premature cases of hypersensitive carotid sinus syndrome
disease, severe bradycardia, severe heart failure neomycin may reduce serum level of digoxin
contractions, atrial or ventricular arrhythmias and
and pulmonary disease, ventricular tachycardia and
conduction defects

Rapid digitalisation: 1-1.5 mg in divided doses over 24 amyloid cardiomyopathy, AV block. Chronic
hours; less urgent digitalisation, 250 mcg-500 mcg daily constrictive pericarditis, electrolyte imbalance (eg. Plasma concentration increased by quinidine,
abdominal pains, salivation, sweating; headache, Ventricular fibrillation, ventricular tachycardia
(higher dose may be divided). Maintenance: 62.5 - 500 hypokalaemia, hypocalcaemia or hypercalcaemia, verapamil, nifedipine, amiodarone.
Heart failure, with atrial fibrillation, supraventricular facial pain, malaise, fatigue, drowsiness, except in certain cases, digitalis toxicity, beriberi
Digoxin 62.5 mcg Tablet Lanoxin mcg dailly (higher dose may be divided) according to hypomagnesaemia), hypothyroidism, hypoxia, Hypokalaemia may be associated with diuretics,
arrhythmias (particularly, atrial fibrillation) depression, disorientation, mental confusion, heart disease, hypersensitivity to digoxin, some
renal fuction, and in atrial fibrillation, on heart-response; idiopathic hypertrophic subaortic stenosis. Renal lithium, carbenoxolone, corticosteroids. Antacids,
delirium, hallucination, visual disturbance. cases of hypersensitive carotid sinus syndrome
usual range :125 - 250 mcg daily (lower doses may be disease, severe bradycardia, severe heart failure neomycin may reduce serum level of digoxin
Ventricular premature contraction
appropriate in the elderly) and pulmonary disease, ventricular tachycardia and
Respiratory depression, obstuctive airway Naltrexone : precipitation of opioid withdrawal
ADULT: 30 - 60 mg every 4 - 6 hours. PAED, over 4 Hypothyroidism, chronic hepatic or adrenocortical GI disturbance, headache, vertigo, respiratory
Dihydrocodeine Tartrate 30 mg Tablet DF 118 For the control of moderate to severe chronic pain disease, acute alcoholism, acute asthmatic symptoms.MAOIs, phenothiazines, CNS
yrs: 0.5 - 1 mg/kg body weight every 4-6 hours disease, renal insufficiency, elderly depression
attack depressants, cimetidine
Dihydroergocristine or Co-dergocrine Adjunct in elderly with mild to moderate dementia, Severe bradycardia, hepatic impairment, pregnancy Nasal stuffiness, initially gastric upsets (take with Hypersensitivity to ergoloid mesilate products, Indinavir, saquinavir, sodium bicarbonate,
Hydergine 3-6 mg daily in divided doses
Mesilate 1 mg Tablet prevention of migraine and vascular headache and lactation food) acute or chronic psychosis macrolides, azole antifungal
AV block (first degree), combination therapy with
beta-blockers (with left ventricular dysfunction),
congestive heart failure, gastrointestinal
Acute myocardial infarction with pulmonary Aspirin, beta-adrenergic blockers,
hypermotility (extended release dose forms),
Treatment of angina pectoris in the following cases: i) congestion, atrial fibrillation or flutter (IV dose carbamazepine, cimetidine, cisapride,
gastrointestinal obstruction (extended release dose
inadequate response or intolerance to beta-blockers 60 mg 3 times daily (elderly initially twice daily); Headache, dizziness, peripheral oedema, forms): i) Accessory bypass tract (Wolff- cyclosporin, digitoxin, digoxin, enflurane, lithium,
Diltiazem HCl 30 mg Tablet Herbesser forms), hypotension, impaired liver function (reduced
and Isosorbide Dinitrate ii) contraindication to beta- increased if necessary to 360 mg daily gingival hyperplasia, AV block, bradycardia Parkinson-White, Lown-Ganong-Levine) ii) Short lovastatin, methylprednisolone, midazolam,
metabolism, enhanced response). Impaired renal
blockers iii) coronary artery spasm PR syndromes. Hypersensitivity to this or other nifedipine, oral anticoagulants, phenytoin,
function. Paroxysmal supraventricular tachycardia
calcium channel blocker quinidine, rifampin, saquinavir, simvastatin
conversion, persistent dermatologic reactions
induced by calcium antagonists have progressed to
erythema multiforme or exfoliative dermatitis
By IM: 2.5 - 3 mg/kg every 4 hours for 2 days, 2 - 4
Poisoning by antimony, arsenic, bismuth, gold, times on the third day, then 1 - 2 times daily for 10 days Nausea, vomiting, headache, tremor,
G6PD, alkyl mercury poisoning, hepatic
Dimercaprol 50 mg/ml Injection BAL mercury, possibly thallium; adjunct (with calcium or until recovery. For ophthalmic use : instillation of 50 Pregnancy, hypertension, acute renal insufficiency rhinorrhoea, lacrimation, elevated blood pressure Not known
insufficiency
disodium edetate) in lead poisoning mg/ml oily solution in conjunctival sac, within 5 minutes and pulse
of contamination
Headache, nausea, vomiting, diarrhoea,
Dimethyl Polysiloxane 20 mg/ml Antifoaming agent for use in upper gastrointestinal 2-4 ml with 10 ml of water 15-40 minutes prior to May possibly be associated with aspiration, Hypersensitivity to simethicone intestinal
Babcon dyspepsia and flatulence, pharyngitis, rhinitis, Not known
Liquid endoscopy endoscopic examination especially in patients with tracheoesophageal fistula perforation and obstruction
skin rashes
Glaucoma elevated intraocular pressure, asthma or Hypersensitivity to dinosprostone, pelvic
history of asthma. Cephalopelvic relationships inflammatory disease, extrauterine pregnancy, Oxytocin: an increased risk of oxytocic toxicity
3 mg vaginal tablet to be inserted high into the posterior Gastrointestinal upsets, uterine hypercontractility
Dinoprostone (Prostagladine E2) 3 mg carefully evaluated prior to use. During use, uterine cephalopelvic disproportion, fetal distress, (uterine hyperstimulation). Wait at least 30
Prostin E2 Induction of labour by vagina formix. A second 3 mg tablet may be inserted after 6-8 with or without fetal bradycardia, rapid cervical
Vaginal Tablet activity, fetal status and progression of cervical placenta previa, hypertonic or hyperactive minutes after removal of vaginal insert before
hours if labour is not established. Max 6 mg dilatation with low Apgar score, headache
dilatation evaluated at frequent intervals. In patients uterine patterns, unexplained vaginal bleeding initiating oxytocin
with history of hypertonic uterine during current pregnancy
i) Acute attack: 6 tablets daily for the first 4 days, then 4
Diosmin 450 mg and Hesperidin 50 tablets daily in 2 divided doses for 3 days and 2 tablets Minor gastrointestinal disturbances,
Daflon i) Haemorrhoids ii) Chronic venous insufficiency Lactation Hypersensitivity to any component of preparation Not known
mg Tablet thereafter. Chronic: 2 tablets daily ii) 2 tab daily with neurovegetative disorders
meals
Sedation, dizziness, coordination problems, dry
Renal or hepatic disease, glaucoma or in patients on Hypersensitivity to diphenhydramine or other
Diphenhydramine HCl 10 mg/5 ml CHILD 2 - 6 years : 6.25 mg 3 - 4 times daily, 6- 12 mucous membranes, blurred vision, paradoxical Additive effects if use with hypnotics, sedatives,
Benadryl Cough and allergic rhinitis MAOIs. May cause drowsiness, may impair ability to antihistamines of similar chemical structure, in
Elixir years : 12.5 - 25 mg 3 - 4 times daily CNS stimulation, nasal stuffiness, palpitation, tranquilizers. Actions prolonged by MAOIs
drive and operate machine breastfeeding, newborns or infants
epigastric discomfort
Sedation, dizziness, coordination problems, dry
Diphenhydramine HCl 14 mg/5 ml and Renal or hepatic disease, glaucoma or in patients on Hypersensitivity to diphenhydramine or other
ADULT : 5 - 10 ml 2 - 3 times daily. CHILD : 2.5 - 5 ml 2 mucous membranes, blurred vision, paradoxical Additive effects if use with hypnotics, sedatives,
Ammonium Chloride 135 mg/5 ml Benadryl Cough MAOIs. May cause drowsiness, may impair ability to antihistamines of similar chemical structure,
- 3 times daily CNS stimulation, nasal stuffiness, palpitation, tranquilizers. Actions prolonged by MAOIs
Expectorant drive and operate machine lactation, newborns or infants
epigastric discomfort
Euphoria, paraesthesia, central nervous system
effects, anoneurotic oedema and other allergic Hypersensitivity to diphenoxylate hydrochloride
reactions, toxic megacolon, paralytic ileus, or atropine, jaundice, acute diarrhoeal conditions
gastrointestinal disturbance. Atropine effects: like antibiotic associated diarrhoea,
Diphenoxylate with Atropine Sulphate ADULT initially 4 tablet followed by 2 tablet 4 times daily Advanced hepatorenal disease, abnormal liver
Lomotil Acute diarrhoea Hyperthermia, tachycardia, urinary retention, pseudomembranous enterocolitis, acute Barbiturates, tranquilizers, alcohol, MAOIs
Tablet until diarrhoea is controlled function, Down Syndrome
flushing, dry skin and mucous membranes. At ulcerative colitis and infective diarrhoeas.
therapeutic dose- dryness of the mouth, difficulty Paralytic ileus and a ganglionosis. Not
in swallowing, thirst, reduce bronchial secretion, recommended for use in children
mydriasis with cycloplegia
Prophylactic: 2 or 3 doses by deep SC or IM injection,
Diphtheria and Tetanus Vaccine Chloramphenicol may inhibit immunologic
Double antigen Immunisation against diphtheria and tetanus 0.5 or 1 ml. Each second dose at 4 - 6 weeks then 4 - 6 Thrombocytopenia or other coagulation disorders Pain, erythema or nodule at the injection site Hypersensitivity to any component of the vaccine
Injection response of tetanus toxoid
months. Booster at 4 - 6 years
Therapeutic: 10,000 - 30,000 units by IM or IV. Increase
Sensitivity testing should be performed before the Hypersensitivity to any components of the
Diphtheria Antitoxin Injection - Diphtheria to 40,000 - 100,000 units in severe cases. Doses up to Anaphylaxis, serum sickness Not known
administration vaccine
30,000 units may be given IM
Pain, erythema or nodule at injection site. Febrile
Diphtheria, Pertussis, Tetanus and reaction (38 - 39 degree celcius) up to 48 hours. Evolving encephalopathy with or without
Tetramune/ Immunisation of children against Haemophilus Type B Presence of fever or acute infection. Do not
Conjugated Haemophilus Type B 10 0.5 ml given by IM Rarely, high fever (less than 40 degree celcius), convulsions. Discontinue vaccination on subjects Not known
TETRAct-Hib infections, diphtheria, tetanus and pertussis administer this product intravascularly
mcg Vaccine high pitch crying syndrome, convulsions, who exhibit strong reaction within 48 hours
encephalopathy, shock
In patients receiving immunosuppressive therapy

or patients with immunodeficiency, an adequate
Primary vaccination: 3 doses of 0.5 ml each within the Redness, swelling and severe tenderness at
Active immunisation against diphtheria, tetanus, Acute severe febrile illness, encephalopathy of response may not be achieved. Incompatibilities:
Diphtheria, Pertussis, Tetanus and first 6 months of life. Administer each dose at intervals injection site. Unusual crying, drowsiness,
Tritanrix-HB pertussis and hepatitis B in infants from 6 weeks Thrombocytopenia or bleeding disorder unknown aetiology. Hypersensitivity to any Until further data are available, the vaccine
Hepatitis B Vaccine of at least 4 weeks. A booster dose can be irritability, gastrointestinal symptoms and feeding
onwards component of the vaccine should not be mixed with other vaccines in the
administered in the second year of life problems
same syringe with the exception of the
lyophilised Hib vaccine (Hiberix)
Any neurological disease, strong reaction to a
By deep SC or IM injection: 3 doses each of 0.5 or 1 ml
previous pertussis vaccine injection: fever more
Diphtheria, Pertussis, Tetanus Prophylactic immunisation against diphtheria, pertussis with intervals of 6 - 8 weeks and 4 - 6 months Pain, erythema or nodule at the injection site,
Triple antigen Thrombocytopenia or other coagulation disorders than 40 degree celcius, shrieking syndrome, Chloramphenicol
Vaccine Injection and tetanus respectively between the doses. Booster 1 and 5 years anaphylaxis, seizure
convulsions, shock happening within 48 hours of
after primary immunisation
injection
Convulsant or non-convulsant progressive
encephalopathy. Children who have experienced
Diphtheria, Tetanus, Acellular Do not administer IV/intradermal. Postpone a strong reaction within 48 hours following a
Immunisation of children against Diphtheria, Tetanus, Injection site reaction, fever, vomiting, diarrhoea,
Pertussis, Inactivated Polio Virus, Primary : 0.5 ml by IM at 1 - 2 months intervals Booster vaccination in children with fever or acute disease. previous vaccination: fever 40°C or more,
Acellular Pertussis, Polio and Haemophilus Influenza loss appetite, restlessness, anorexia, Not known
Haemophilus Influenza Type B : Second year of life Patients on immunosuppressive treatment or with persistent crying syndrome, febrile or non-febrile
Type B infection somnolence, fatigue
Vaccine [DTaP-IPV- Hib] immune deficiency convulsion, hypotonus-hyporeactivity syndrome.
Hypersensitivity to neomycin, streptomycin,
polymyxin B
Gastrointestinal effects, dizziness, myalgia,
headache, hypotension, hot flushes and
Rapidly worsening angina, aortic stenosis, recent
As an adjunct to oral anticoagulation/ antiplatelet 75-150 mg 3 times daily to be taken 1 hour before tachycardia, rash, urticaria, exacerbation of Hypersensitivity to dipyridamole or tartrazine dye Adenosine, indomethacin, low molecular weight
Dipyridamole 75 mg Tablet Persantin myocardial infarction, heart failure, may exacerbate
therapy in the prophylaxis of cerebrovascular events meals angina pectoris, bronchospasm and (25 mg tablets) heparins, streptokinase, theophylline
migraine, hypotension, myasthenia gravis
angioedema, increased bleeding during and after
surgery
Severe constipation, intestinal or urinary
i) ADULT : 5 mg daily 30 minutes before breakfast. Dyspnoea, muscle twitching, urinary frequency, obstruction or where increased muscular activity
Increase at intervals of 3 - 4 days if necessary to Cardiac disorder, hyperthyrodism, epilepsy, nausea, vomiting, hyperperistalsis, abdominal of urinary or gastrointestinal tract harmful,
i) Myasthenia gravis ii) Prevention and treatment of
maximum of 20 mg daily. CHILD : Up to 10 mg daily parkinsonism, bradycardia, duodenal ulcer, gastric cramps, increased salivation, diarrhea, muscle asthma, postoperative shock, serious circulatory Antiarrythmics, antimalarials, antibacterials,
Distigmine Bromide 5 mg Tablet Ubretid post-operative intestinal atony, urinary retention and
according to age ii) Urinary retention : 5 mg daily 30 ulcer, enteritis, hypotension, myocardial infarction, spasms, muscle weakness, seizures, insufficiency, bile duct spasm or stenosis, lithium
neurogenic bladder
minutes before breakfast. Neurogenic bladder : 5 mg tetany lacrimation, miosis, blurred vision, congestive heart failure, hypersensitivity to
daily or on alternate days 30 minutes before breakfast bronchospasm, menstrual-like bleeding distigmine or bromides, lactation, parkinsonism,
myotonia, pregnancy, thyrotoxicosis
Use on the face and genitals. Should not be
Dithranol 0.1 - 5% in Vaseline/ Short contact treatment for plaque psoriasis and Use as short contact. Apply for not more than 5 hour May cause a burning sensation especially on
- Irritant to the eyes and mucous membranes used for acute or pustular psoriasis or on Not known
Ointment alopecia areata then wash off. Apply carefully to lesions perilesional skin
inflammed skin
Use on the face and genitals. Should not be
Treatment of quiescent or chronic psoriasis of the skin, Apply liberally and carefully to the lesions with a May cause a burning sensation especially on
Dithranol 1 % in Lassars Paste - Irritant to the eyes and mucous membranes used for acute or pustular psoriasis or on Not known
scalp and alopecia areata suitable applicator. A dressing may be applied perilesional skin
inflammed skin
Arrhythmias, hypovolaemia . May be ineffective in
patients who have recently received a beta-blocker,
Increased heart rate, blood pressure and
Initial 0.5-1 mcg/kg/min by IV; maintenance 2.5-20 in such cases peripheral vascular resistance may
Dobutamine HCl 250 mg/20 ml ventricular ectopic activity, , anginal pain, Hypersensitivity to dobutamine, idiopathic
Dobutrex Hypotension and heart failure mcg/kg/min by IV; titrate according to response; increase. Monitor EKG and blood pressure Beta-blockers, nitroprusside
Injection nonspecific chest pain, palpitations shortness of hypertrophic subaortic stenosis
maximum dose 40 mcg/kg/min constantly, serum potassium, pulmonary wedge
breath, nausea, headache
pressure and cardiac output. Myocardial infarction
and severe coronary artery disease.
i) 75 mg/m2 IV over 1 hour after doxorubicin 50 mg/m2
i)Adjuvant treatment of patients with high risk node- and cyclophosphamide 500 mg/m2 every 3 weeks for 6
positive breast cancer in combination with doxorubicin cycles ii) 75 mg/m2 IV over 1 hour every 3 week in
and cyclophosphamide ii) Breast cancer, locally combination with doxorubicin 50 mg/m2 iii) Administer Fluid retention syndrome, hypersensitivity
Increased risk of infection by the live vaccine.
advanced or metastatic, not previously on cytotoxic IV over 1 hour every 3 weeks. Chemotherapy-naive reactions. rash, alopecia, oedema, peripheral
All patients should receive premedication with Drugs which affect liver cytochrome P450
therapy, in combination with doxorubicin iii) First line patients 75 mg/m2 immediately followed by 75 mg/m2 neuropathy, myelosuppression, elevation of liver Hypersensitivity to docetaxel or Polysorbate 80,
corticosteroids against hypersensitivity reactions. enzyme system may affect the antitumour and
Docetaxel 20 mg/0.5 ml Injection Taxotere therapy in non small cell lung cancer in stage 3- 4 and cisplatin over 30-60 mins or carboplatin (AUC 6 enzymes, nausea, vomiting, stomatitis, neutrophil count less than 1500 cells/mm³.
Monitor blood counts, liver function tests. Avoid toxic effects of docetaxel. Less toxicity if taxanes
performance status 0 ? 1, in combination with cisplatin mg/mL/min) over 30-60 minutes. Monotherapy of non diarrhoea, fatigue, weakness, paroxysmal atrial Severe liver impairment. Pregnancy and lactation
extravasation given before platinum compounds if combination
iv) Inoperable locally advanced squamous cell small cell lung cancer (NSCLC) after failure of prior tachycardia, atrial flutter, dysrrhythmia,
of taxane and platinum is used
carcinoma of head and neck, in combination with platinum-based chemotherapy 75 mg/m2 iv) 100 hypertension and heart failure
cisplatin and 5-FU for induction treatment v) Prostate mg/m2 IV over 1 hour every 3 weeks v) 60-75 mg/m2
cancer, in combination with prednisolone IV over 1 hour every 3 weeks, administer with oral
prednisolone 5 mg twice daily given continously
i) 75 mg/m2 IV over 1 hour after doxorubicin 50 mg/m2
i) Adjuvant treatment of patients with high risk node- and cyclophosphamide 500 mg/m2 every 3 weeks for 6
positive breast cancer in combination with doxorubicin cycles ii) 75 mg/m2 IV over 1 hour every 3 week in
and cyclophosphamide ii) Breast cancer, locally combination with doxorubicin 50 mg/m2 iii) Administer Fluid retention syndrome, hypersensitivity
Increased risk of infection by the live vaccine.
advanced or metastatic, not previously on cytotoxic IV over 1 hour every 3 weeks. Chemotherapy-naive reactions. rash, alopecia, oedema, peripheral
All patients should receive premedication with Drugs which affect liver cytochrome P450
therapy, in combination with doxorubicin iii) First line patients 75 mg/m2 immediately followed by 75 mg/m2 neuropathy, myelosuppression, elevation of liver Hypersensitivity to docetaxel or Polysorbate 80,
corticosteroids against hypersensitivity reactions. enzyme system may affect the antitumour and
Docetaxel 80 mg /2 ml Injection Taxotere therapy in non small cell lung cancer in stage 3- 4 and cisplatin over 30-60 mins or carboplatin (AUC 6 enzymes, nausea, vomiting, stomatitis, neutrophil count less than 1500 cells/mm³.
Monitor blood counts, liver function tests. Avoid toxic effects of docetaxel. Less toxicity if taxanes
performance status 0 ? 1, in combination with cisplatin mg/mL/min) over 30-60 minutes. Monotherapy of non diarrhoea, fatigue, weakness, paroxysmal atrial Severe liver impairment. Pregnancy and lactation
extravasation given before platinum compounds if combination
iv) Inoperable locally advanced squamous cell small cell lung cancer (NSCLC) after failure of prior tachycardia, atrial flutter, dysrrhythmia,
of taxane and platinum is used
carcinoma of head and neck, in combination with platinum-based chemotherapy 75 mg/m2 iv) 100 hypertension and heart failure
cisplatin and 5-FU for induction treatment v) Prostate mg/m2 IV over 1 hour every 3 weeks v) 60-75 mg/m2
cancer, in combination with prednisolone IV over 1 hour every 3 weeks, administer with oral
prednisolone 5 mg twice daily given continously
Chronic dyspepsia : CHILD 2.5 mL/10 kg body weight 3 Known hypersensitivity to domperidone or any of MAOIs, antacids, antisecretory drugs, azole
times daily and once more in the evening if necessary. the excipients. Prolactin-releasing pituitary antifungals, macrolide antibiotics, HIV protease
Dosage may be doubled in adults & childs over 1 year. Baby under 1 year, hepatic impairment, renal Mild abdominal cramps, raised serum prolactin tumour(prolactinoma). Should not be used when inhibitors, anticholinergic drugs, CYP3A4
Domperidone 1 mg/ml Suspension Motilium Nausea, vomiting, dyspepsia, gastro-esophageal reflux
Acute and subacute conditions (particularly nausea and insufficieny, pregnancy and lactation level stimulation of gastric motility could be harmful:
inhibitors. Antacids or antisecretory agents
vomiting). CHILD: 5 mL/10 kg bodyweight. All to be gastro-intestinal haemorrhage, should be taken after meals when used
taken 3-4 times daily mechanicalobstruction or perforation concomitantly
Known hypersensitivity to domperidone or any of MAOIs, antacids, antisecretory drugs, azole
the excipients. Prolactin-releasing pituitary antifungals, macrolide antibiotics, HIV protease
Chronic dyspepsia ADULT 10 mg 3 times daily. Acute Dosage adjustment may be necessary in patients
Mild abdominal cramps, raised serum prolactin tumour(prolactinoma.) Should not be used when inhibitors, anticholinergic drugs, CYP3A4
Domperidone 10 mg Tablet Motilium Nausea, vomiting, dyspepsia, gastro-esophageal reflux and subacute conditions (particularly nausea and who are receiving domperidone concomitantly with
level stimulation of gastric motility could be harmful:
inhibitors. Antacids or antisecretory agents
vomiting):ADULT 20 mg 3-4 times daily cimetidine,pregnancy, lactation
gastro-intestinal haemorrhage, mechanical should be taken after meals when used
obstruction or perforation concomitantly
Has the potential for synergistic activity with
Gastrointestinal disease or history of ulcer disease,
concurrent succinylcholine, other neuromuscular
Treatment of mild to moderate dementia in Alzheimer's asthma or obstructive pulmonary disease or Diarrhoea, muscle cramps, nausea, vomiting,
Hypersensitivity to donepezil hydrochloride and blocking agents or cholinergic agonist. Has the
Donepezil HCl 10 mg Tablet Aricept disease, as well as in patients with severe Alzheimer's 5 - 10 mg once daily at bedtime. Maximum 10 mg daily seizures or those receiving concurrent NSAIDs, insomnia, fatigue, dizziness, hallucination,
piperidine derivatives. Pregnancy and lactation potential to interfere with drugs having
disease. [psychiatrists and neurologists only] pregnancy, cardiac conduction abnormalities, agitation, loss of appetite
anticholinergic activity. Muscle relaxants drugs,
anaesthesia with succinylcholine
suxamethonium
Has the potential for synergistic activity with
Gastrointestinal disease or history of ulcer disease,
concurrent succinylcholine, other neuromuscular
Treatment of mild to moderate dementia in Alzheimer's asthma or obstructive pulmonary disease or Diarrhoea, muscle cramps, nausea, vomiting,
Hypersensitivity to donepezil hydrochloride and blocking agents or cholinergic agonist. Has the
Donepezil HCl 5 mg Tablet Aricept disease, as well as in patients with severe Alzheimer's 5 - 10 mg once daily at bedtime. Maximum 10 mg daily seizures or those receiving concurrent NSAIDs, insomnia, fatigue, dizziness, hallucination,
piperidine derivatives. Pregnancy and lactation potential to interfere with drugs having
disease. [psychiatrists and neurologists only] pregnancy, cardiac conduction abnormalities, agitation, loss of appetite
anticholinergic activity. Muscle relaxants drugs,
anaesthesia with succinylcholine
suxamethonium
Angina pectoris, conditions such as hypovolaemia,
hypoxia, hypercapnia, and acidosis should be
Initial dose 2-5 mcg/kg/min with incremental changes
corrected prior to administration of dopamine.
of 5-10 mcg/kg/min at 10-15 minutes intervals until Increased heart rate, blood pressure and
Patients allergic to sulfite. Patients receiving MAOIs
adequate response is noted. Most patients are ventricular ectopic activity, anginal pain, Pheochromocytoma, tachyarrhythmias or Beta-blockers, methyldopa, phenytoin, tricyclic
Dopamine HCl 40 mg/ml Injection Intropin Non-hypovolemic hypotension will exhibit enhanced dopamine effects. Patients with
maintained at less than 20 mcg/kg/min. If dosage nonspecific chest pain, palpitations and ventricular fibrillation antidepressants
pre-existing vascular damage secondary to
exceeds 50 mcg/kg/min, assess renal function shortness of breath, nausea, headache
atherosclerosis, diabetes, Raynaud's disease or
frequently
frostbite since dopamine can produce peripheral
necrosis or gangrene
Patients with severe renal or hepatic impairment.
Monotherapy : 1 drop 3 times daily. Adjunctive therapy Pregnancy and lactation. Children. Remove contact Burning, stinging, conjunctivitis, eyelid
with an ophthalmic beta-blocker : 1 drop 2 times daily. lens prior to administration and do not reinsert 15 inflammation, eye itching, eyelid irritations,
When substituting for another ophthalmic antiglaucoma minutes after use. Acute angle glaucoma, sensitivity headache, bitter taste, nausea, itching,
All glaucoma patients where beta-blockers are
Dorzolamide HCl 2% Ophthalmic agent with this product, discontinue the other agent to sulfonamide, concomitant use of oral carbonic- fatigue/asthenia, blurred vision, tearing. Rarely, Patients who are hypersensitive to any High dose of salicylate therapy. Potential additive
Trusopt contraindicated and when intraocular pressure is not
Solution after proper dosing on one day and start Trusopt on the anhydrase inhibitors, conjunctivitis and lid reactions iridocyclitis and rash. Angioedema, component of this product effect with oral carbonic anhydrase inhibitors
well controlled by other drugs
next day. If more than 1 topical ophthalmic drug is reported with chronic administration, ocular infection bronchospasm, urticaria, pruritis, dizziness,
used, the drugs should be administered at least 10 or inflammation, recent ocular surgery, reports of paraesthesia, transient myopia (resolve upon
mins apart bacterial keratitis associated with the use of multiple discontinuation) and superficial punctate keratitis
dose containers of ophthalmic products
Drowsiness, extrapyramidal symptoms, tremor, Alcohol, barbiturate, tranquilliser, MAOIs,
Initially 75 mg (ELDERLY 50-75 mg) daily in divided confusional state, disorientation, dizziness, anticholinergic, antihistamine,
doses or single dose at bedtime, increased gradually May activate latent schizophrenia, exaggerate anticholinergic effects, paraesthesia, sympathomimetics, 5 HT agonist,
Concomitant use of MAOIs, recovery phase of
Dothiepin HCl 25 mg Capsule Prothiaden Depression of any aetiology as necessary to 150 mg daily (ELDERLY 75 mg may paranoid delusions, renal or hepatic impairment, hypotension, tachycardia, palpitations, benzodiazepines, carbamazepine, clozapine,
myocardial infarction, hepatic failure, epilepsy
be sufficient), up to 225 mg daily in some Pregnancy, lactation and children less than 16 years arrhythmias, conduction defects, libido changes, cyclosporine, digoxin, haloperidol, phenytoin,
circumstances. CHILD is not recommended nausea, vomiting, constipation, rash, pharyngitis, linezolid, metoclopramide, ritonavir, tramadol,
impotence, anemia lithium, NSAIs, thioridazine, warfarin
Drowsiness, extrapyramidal symptoms, tremor, Alcohol, barbiturate, tranquilliser, MAOIs,
Initially 75 mg (ELDERLY 50-75 mg) daily in divided confusional state, disorientation, dizziness, anticholinergic, antihistamine,
doses or single dose at bedtime, increased gradually May activate latent schizophrenia, exaggerate anticholinergic effects, paraesthesia, sympathomimetics, 5 HT agonist,
Concomitant use of MAOIs, recovery phase of
Dothiepin HCl 75 mg Tablet Prothiaden Depression of any aetiology as necessary to 150 mg daily (ELDERLY 75 mg may paranoid delusions, renal or hepatic impairment, hypotension, tachycardia, palpitations, benzodiazepines, carbamazepine, clozapine,
myocardial infarction, hepatic failure, epilepsy
be sufficient), up to 225 mg daily in some Pregnancy, lactation and children less than 16 years arrhythmias, conduction defects, libido changes, cyclosporine, digoxin, haloperidol, phenytoin,
circumstances. CHILD is not recommended nausea, vomiting, constipation, rash, pharyngitis, linezolid, metoclopramide, ritonavir, tramadol,
impotence, anemia lithium, NSAIs, thioridazine, warfarin
In patients currently on beta blockers, the first
Gastrointestinal disorders, pregnancy, lactation, dose response (marked initial drop in blood
Postural hypotension, vertigo, headache, fatigue, Hypersensitivity to doxazosin and other
Doxazosin Mesilate 4 mg CR Tablet Cardura XL Benign Prostatic Hyperplasia 4 mg once daily history of gastrointestinal obstruction, oesophageal pressure, particularly on standing) to an alpha-1
dizziness, oedema and asthenia quinazolines
obstruction adrenergic blocking drug may be exaggerated,
tadalafil, sildenafil, vardenafil
i) 30 - 75 mg/m2 IV as a single dose at 21 day intervals
ii) 25 - 45 mg/m2 once a week for the first 4 weeks
Alopecia, myelosuppression, mucositis, Hypersensitivity to doxorubicin, marked
during induction or re-induction phase (refer to specific
diarrhoea, hyperpigmentation of skin and nails, myelosuppression induced by previous Live vaccines, phenytoin, radiation therapy,
protocol. Caution: Total cumulative dose of doxorubicin
Cardiac failure, heart disease, hypertension. arrhythmias, congestive heart failure, nausea, chemotherapy or radiotherapy. Previous mitomycin C, 6-mercaptopurine,
i) Solid tumours, leukaemia, non-Hodgkin's lymphoma must not exceed 550 mg/m2 due to risk of
Doxorubicin HCl 10 mg Injection Adriamycin Previous radiotherapy to chest, elderly. Avoid in vomiting, discolouration of urine, palmar-plantar treatment with tolerance doses of anthracyclines, cyclophosphamide, 5-fluorouracil, ciclosporin,
ii) Leukaemia (ALL induction) iii) Multiple myeloma cardiotoxicity. CHILD: 30 mg/m2/dose over 6 - 24 hours
pregnancy and lactation. Avoid extravasation erythrodysethesia, pericardial effusion, significantly impaired cardiac function, angina digoxin, paclitaxel, phenobarbital, trastuzumab,
for 1 - 2 days. Need to check cardiac function closely
cardiomyopathy, radiation recall reactions, pectoris, cardiac arrhythmias or recent stavudine, zidovudine
by echocardiography every cumulative dose of 100
second malignancy myocardial infarction.
mg/m2 to maximum 360 mg/m2 iii) 9 mg/m2 over 24
hours infusion for 4 days at monthly intervals
i) 30 - 75 mg/m2 IV as a single dose at 21 day intervals
ii) 25 - 45 mg/m2 once a week for the first 4 weeks
Alopecia, myelosuppression, mucositis, Hypersensitivity to doxorubicin, marked
during induction or re-induction phase (refer to specific
diarrhoea, hyperpigmentation of skin and nails, myelosuppression induced by previous Live vaccines, phenytoin, radiation therapy,
protocol. Caution: Total cumulative dose of doxorubicin
Cardiac failure, heart disease, hypertension. arrhythmias, congestive heart failure, nausea, chemotherapy or radiotherapy. Previous mitomycin C, 6-mercaptopurine,
i) Solid tumours, leukaemia, non-Hodgkin's lymphoma must not exceed 550 mg/m2 due to risk of
Doxorubicin HCl 50 mg Injection Adriamycin Previous radiotherapy to chest, elderly. Avoid in vomiting, discolouration of urine, palmar-plantar treatment with tolerance doses of anthracyclines, cyclophosphamide, 5-fluorouracil, ciclosporin,
ii) Leukaemia (ALL induction) iii) Multiple myeloma cardiotoxicity. CHILD: 30 mg/m2/dose over 6 - 24 hours
pregnancy and lactation. Avoid extravasation erythrodysethesia, pericardial effusion, significantly impaired cardiac function, angina digoxin, paclitaxel, phenobarbital, trastuzumab,
for 1 - 2 days. Need to check cardiac function closely
cardiomyopathy, radiation recall reactions, pectoris, cardiac arrhythmias or recent stavudine, zidovudine
by echocardiography every cumulative dose of 100
second malignancy myocardial infarction.
mg/m2 to maximum 360 mg/m2 iii) 9 mg/m2 over 24
hours infusion for 4 days at monthly intervals
GI distress, anorexia, maculopapular and Hypersensitivity to tetracyclines/doxycycline,
ADULT: 200 mg on the first day followed by 100 mg Lactation, myasthenia gravis, hepatic or renal Anticoagulants, penicillin, antacids, ferum,
Doxycycline 100 mg Capsule Vibramycin Infections due to susceptible organisms erythematous rash, tooth discolouration in porphyria, pregnancy, lactation, children less
daily. Severe infections: 200 mg daily impairment acitretin, isotretinoin, methotrexate
children than 12 years
GI distress, anorexia, maculopapular and Hypersensitivity to tetracyclines/doxycycline,
ADULT: 200 mg on the first day followed by 100 mg Lactation, myasthenia gravis, hepatic or renal Anticoagulants, penicillin, antacids, ferum,
Doxycycline 100 mg Tablet Vibramycin Infections due to susceptible organisms erythematous rash, tooth discolouration in porphyria, pregnancy, lactation, children less
daily. Severe infections: 200 mg daily impairment acitretin, isotretinoin, methotrexate
children than 12 years
CHILD over 8 years less than 45 kg body weight: 4.4 GI distress, anorexia, maculopapular & Hypersensitivity to tetracyclines/doxycycline,
Lactation, myasthenia gravis, hepatic or renal Anticoagulants, penicillin, antacids, ferum,
Doxycycline 5 mg/ml Syrup Vibramycin Infections due to susceptible organisms mg/kg body weight on first day, then 2.2 - 4.4 erythematous rash, tooth discolouration in porphyria, pregnancy, lactation, child less than
impairment acitretin, isotretinoin, methotrexate
mg/kg/day children 12 years
i) Treatment of severe lead poisoning, it is used as
i) 1.5 - 2 g daily in divided doses before food, Penicillamine-related aplastic
adjunctive treatment following initial treatment with
maximum: 2 g daily for a year. Maintenance : 0.75 - 1 g Nausea, vomiting, myelosuppression, taste anaemia/agranulocytosis, hypersensitivity to Alluminium hydroxide or phosphate, magnesium
another chelating agent. May also be used as sole Allergy to penicillin, concomitant gold therapy,
D-Penicillamine 0.25 g Capsule Cuprimine daily ii) Initially 500 mg daily in divided doses, disorders, proteinuria, myasthenia gravis, optic penicillamine producs, myasthenia gravis, carbonate or hydroxide or oxide or trisilicate,
therapy in the treatment of asymptomatic patients with antimalarial, cytotoxic drug, renal dysfunction
increased slowly over 3 months; usual maintenance : neuritis, tinnitus pregnancy, lactation, rheumatoid arthritis iron, digoxin, aurothioglucose
moderately elevated blood concentrations ii) Wilson's
1.25 g daily. Elderly not recommended patients with history of renal insufficient
Disease: to aid in elimination of copper ions
History of mania/hypomania, seizures, renal
impairment, elderly, liver transaminase elevations, Drugs metabolised by CYP2D6 (eg flecainide,
Gastrointestinal disorders, excessive sweating, Concomitant use with MAOIs, potent CYP1A2
pregnancy and lactation, suicidal ideation and vinblastine, carbamazepine, tricyclic
ADULT: 60 mg once daily up to a maximum dose of CNS disorders (eg dizziness, fatigue, insomnia, inhibitors, hepatic or severe renal impairment,
Major depressive disorder, diabetic peripheral behavior or worsening depression, controlled narrow- antidepressants), potent CYP1A2
Duloxetine 30 mg Capsule Cymbalta 120mg/day (in divided doses) CHILD and somnolence, blurred vision, dysuria), uncontrolled narrow-angle glaucoma,
neuropathic pain angle glaucoma, diabetes; may worsen glycemic inhibitors/inducers, CNS-active drugs (eg
ADOLESCENT under 18 years not recommended hepatotoxicity, suicidal thought, increased hypersensitivity to duloxetine or any other
control, hepatic impairment; increased risk of liver diazepam, imipramine, phenytoin, haloperidol,
urinary frequency, increased libido, palpitation component of the product
injury and aggravation of pre-existing liver disease, alcohol)
hepatic insufficiency; risk of drug toxicity
History of mania/hypomania, seizures, renal

impairment, elderly, liver transaminase elevations, Drugs metabolised by CYP2D6 (eg flecainide,
Gastrointestinal disorders, excessive sweating, Concomitant use with MAOIs, potent CYP1A2
pregnancy and lactation, suicidal ideation and vinblastine, carbamazepine, tricyclic
ADULT: 60 mg once daily up to a maximum dose of CNS disorders (eg dizziness, fatigue, insomnia, inhibitors, hepatic or severe renal impairment,
Major depressive disorder, diabetic peripheral behavior or worsening depression, controlled narrow- antidepressants), potent CYP1A2
Duloxetine 60 mg Capsule Cymbalta 120mg/day (in divided doses) CHILD and somnolence, blurred vision, dysuria), uncontrolled narrow-angle glaucoma,
neuropathic pain angle glaucoma, diabetes; may worsen glycemic inhibitors/inducers, CNS-active drugs (eg
ADOLESCENT under 18 years not recommended hepatotoxicity, suicidal thought, increased hypersensitivity to duloxetine or any other
control, hepatic impairment; increased risk of liver diazepam, imipramine, phenytoin, haloperidol,
urinary frequency, increased libido, palpitation component of the product
injury and aggravation of pre-existing liver disease, alcohol)
hepatic insufficiency; risk of drug toxicity
Concurrent use of CYP3A4 enzyme inhibitors (e.g.

Impotence, decrease libido, ejaculation
ritonavir), capsules should not be handled by women
Benign prostatic hyperplasia in men with an enlarged disorders, gynaecomastia, breast tenderness, Severe hepatic impairment, women, child and Verapamil, diltiazem, cimetidine, ciprofloxacin,
Dutasteride 0.5 mg Capsule Avodart 0.5 mg daily who are pregnant or who may become pregnant due
prostate gland allergic reactions including rash, prutitus, adolescent ketoconazole, ritonavir
to the possibility of absorption of dutasteride through
urticaria and localized edema.
the skin and the potential risk of a fetal anomaly
i) 10 mg bd from day 5 - 25 of cycle ii) 10 mg bd - tds

from day 5 - 25 of the cycle or continuously iii) To arrest Enzyme inducing drugs such as carbamazepine,
i) Dysmenorrhoea ii) Endometriosis iii) Dysfunctional
bleeding :10 mg bd with an oestrogen once daily for 5 - griseofulvin, phenobarbitone, phenytoin and
uterine bleeding (to arrest and to prevent bleeding) iv)
7 days, To prevent bleeding : 10 mg bd with an Breakthrough bleeding, altered liver function, Breast and genital cancers, abnormal vaginal rifampicin may enhance the clearance of
Dydrogesterone 10 mg Tablet Duphaston Threatened abortion v) Habitual abortion vi) Post Pregnancy
oestrogen once daily from day 11 - 25 of the cycle iv) angioedema, haemolytic anaemia bleeding progesterone. Progesterone may inhibit
menopausal complaints (hormone replacement therapy
40 mg at once, then 10mg 8hrly until symptoms remit v) ciclosporin metabolism leading to increased
in combination with oestrogen)
10 mg bd until 20th week of pregnancy vi) 10-20 mg plasma-ciclosporin
daily during last 12-14 days of each cycle.
Overdosage may lead to a 'cholinergic crisis'.
Increased gastrointestinal secretions,
i) Intravenous injection on over several minutes, 500 - Patients who have undergone recent intestinal or
hypotension, bradycardia, increased salivation, Gastrointestinal or urinary obstruction,
700 mcg/kg (after or with atropine sulphate 600 mcg) ii) bladder surgery and in patients with bronchial
Edrophonium Chloride 10 mg/ml i) For reversal of neuromuscular block ii) Diagnosis of nausea, vomiting, abdominal cramps, diarrhoea, hypersensitivity to edrophonium products, Antagonism effect by antimuscarinic.
Tensilon Intravenous injection 2 mg followed by 8 mg if no asthma and respiratory distress (extreme caution)
Injection myasthenia gravis allergic reactions, seizure, increased frequency intestinal or urinary obstruction of the mechanical Succinylcholine
response occurs within 30 seconds. CHILD: 20 mcg cardiovascular disorders including arrhythmias,
of urination, cardiac arrest, bronchospasm, type
followed by 80 mcg/kg after 30 seconds bradycardia, recent myocardial infarction and
respiratory tract paralysis
hypotension
ADULT: 600 mg once daily. ADOLESCENT & CHILD Dizziness, nausea, headache, fatigue, rash
less than 17 years, more than 40 kg: 600 mg once including erythema multiforme & Stevens- Amprenavir, indinavir, ritonavir, saquinavir,
daily, 32.5 - less than 40 kg: 400 mg once daily, 25 - Johnson Syndrome, allergic reaction, abnormal rifamycins, clarithromycin, oral contraceptives,
Combination therapy for HIV infections with a protease less than 32.5 kg: 350 mg once daily, 20 - less than 25 coordination, ataxia, confusion, stupor, vertigo, Hypersensitivity, concomitant terfenadine, anticonvulsants, methadone, St. John's wort,
Efavirenz 100 mg Capsule Stocrin inhibitor and or Nucleoside Reverse Transcriptase kg: 300 mg once daily, 15 - less than 20 kg: 250 mg Pregnancy, lactation and renal impairment vomiting, diarrhoea, hepatitis, impaired cisapride, midazolam, triazolam and ergot sertraline, cetirizine, lorazepam. Other
Inhibitors (NRTIs) once daily, 13 - less than 15 kg: 200 mg once daily. No concentration, insomnia, anxiety, abnormal derivatives compounds that are substrates of CYP3A4 may
studies in children less than 3 years or less than 13 kg. dreams, somnolence, depression, abnormal have decreased plasma concentration when
Tablet formulation unsuitable for children less than 40 thinking, agitation, amnesia, delirium, emotional coadministered with efavirenz
kg liability, euphoria, hallucination and psychosis
Efavirenz 600 mg Tablet Stocrin inhibitor and or Nucleoside Reverse Transcriptase kg: 300 mg once daily, 15 - less than 20 kg: 250 mg Pregnancy, lactation, renal impairment vomiting, diarrhoea, hepatitis, impaired cisapride, midazolam, triazolam and ergot sertraline, cetirizine, lorazepam. Other
Should not be used before phototherapy or in
Emulsificants Ointment - Xerosis and ichthyosis Use as a soap and emollient Not known Hypersensitivity to any component Not known
phototesting procedures
Symptomatic hypotension likely to occur in volume
depleted patients eg. by diuretic therapy, dietary salt
restriction, dialysis, diarrhoea or vomiting, patients
with heart failure with or without associated renal
insufficiency. Caution in severe heart failure,
i) Initially 5 mg daily, (ELDERLY 2.5 mg once daily), Angioedema induced by other angiotensin May have additive effects with other
especially ischemic heart or cerebrovascular Dizziness, headache, diarrhoea, fatigue,
usual maintenance dose 10 - 20 mg daily. Maximum: converting enzyme (ACE) inhibitors. antihypertensives, potassium supplement,
disease. Patients with obstruction in the outflow tract asthenia, cough, orthostatic hypotension,
Enalapril 10 mg Tablet Renitec i) Hypertension ii) Congestive heart failure 40 mg/day in 1 - 2 divided doses ii) Initially 2.5 mg daily, Hypersensitivity to this or any other angiotensin potassium-sparing diuretics or potassium-
of the left ventricle. Renal impairment patients with hyperkalaemia, angioneurotic oedema
usual maintenance dose 20 mg daily in 1 - 2 divided converting enzyme inhibitor. Pregnancy (second containing salt substitutes. Increased lithium
bilateral renal artery stenosis or stenosis of the (discontinue therapy)
doses; maximum: 40 mg/day and third trimesters particularly) level
artery to a solitary kidney. Dosage reduction and or
discontinuation of the diuretic and or enalapril may
be required. Serum potassium should be monitored.
Not recommended during pregnancy. Lactation.
Children
Enalapril 20 mg Tablet Renitec i) Hypertension ii) Congestive heart failure 40 mg/day in 1 - 2 divided doses ii) Initially 2.5 mg daily, hypersensitivity to this or any other angiotensin potassium-sparing diuretics or potassium-
Children
Enalapril 5 mg Tablet Renitec i) Hypertension ii) Congestive heart failure 40 mg/day in 1 - 2 divided doses ii) Initially 2.5 mg daily, Hypersensitivity to this or any other angiotensin potassium-sparing diuretics or potassium-
Children
Carefully monitor patients for possible spinal or

epidural bleeding and if neurological impairment is
detected, treat immediately. Active or history of
i) Prophylaxis fo DVT especially in surgical patients: recent gastrointestinal ulceration and haemorrhage,
moderate risk, 20 mg SC approximately 2 hours before bacterial endocarditis, bleeding diathesis.
surgery then 20 mg every 24 hours for minimum 7 - 10 Concomitant therapy with agents that inhibit
days, high risk (eg orthopaedic surgery, medical platelets. Congenital or acquired bleeding disorders.
i) Prevention of Deep Vein Thrombosis(DVT) especially Increased risk of haemorrhage when used with
patients, 40mg every 24 hours for at least 6 days until Do not give via intramuscular injection. Elderly Haemorrhagic symptoms, thrombocytopenia Active major bleeding, hypersensitivity to
in perioperative and high risk surgical cases ii) NSAIDs, ticlopidine, corticosteroids, dextran 40.
Enoxaparin Sodium 20 mg Injection Clexane patient ambulant, max 14 days. ii) Treatment of DVT or patients and patients with renal insufficiency may (rare), haematomas & skin necrosis at injection enoxaparin, heparin, thrombocytopenia due to
Treatment of DVT iii) Unstable angina and non Q wave May potentiate effects of oral anticoagulants. Vit
pulmonary embolism, 1.5 mg/kg every 24 hours, experience delayed elimination of enoxaparin. site; skin allergies or systemic allergic reactions enoxaparin, acute GI ulcer
Myocardial Infarction K antagonists, anti-platelet drugs
usually for 5 days and until adequate oral Haemorrhagic stroke, post-op period following brain
anticoagulation established. iii) Unstable angina and & spinal cord or ophthalmological surgery.
non-ST-segment-elevation myocardial infarction 1 Uncontrolled arterial hypertension. Use with extreme
mg/kg every 12 hours, usually for 2 - 8 days caution in patients with history of heparin-induced
thrombocytopenia. Diabetic retinopathy, low
molecular weight heparins or unfractionated heparin
cannot be used interchangeably, unit for unit


Nausea, vomiting, abdominal pain, constipation,

Entacapone and ferrous product should be taken
diarrhoea, urine may be coloured reddish-brown,
at least 2 - 3 hours apart. Dosage of levodopa
dry mouth, dyskinesia, dizziness, anaemia,
and other antiparkinson drugs may need to be
Parkinson's Disease. An adjunct to standard rarely elevated liver enzymes, gastrointestinal Pregnancy and breast-feeding, hepatic
adjusted when initiating entacapone. Effects of
levodopa/benserazide or levodopa/carbidopa for use in 200 mg to be taken with each daily dose of symptoms, insomnia, hallucinations, confusion, impairment, phaeochromocytoma, history of
Levodopa-induced orthostatic hypotension may be medicinal products metabolised by catechol-O-
Entacapone 200 mg Tablet Comtan patients with parkinson's disease and end of dose levodopa/dopa-decarboxylase inhibitor. May be taken paroniria, aggravated parkinsonism, dizziness, neuroleptic malignant syndrome or non-traumatic
aggravated. Abrupt withdrawal methyl transferase (COMT) may be potentiated.
motor fluctuations, who cannot be stabilised on those with or without food dystonia, hyperkinesia, fatigue, increased rhabdomyolysis. Concomitant use with selective
MAO-A inhibitors, tricyclic antidepressants,
combinations sweating, fall. Extremely rare (potentially serious and nonselective MAO-A and MAO-B inhibitors
noradrenaline reuptake inhibitors, medicinal
adverse reactions): Hepatitis, sudden sleep
products metabolized by COMT, selegiline,
onset episodes, neuroleptic malignant syndrome,
warfarin
rhabdomyolysis
Drugs that reduce renal function or compete for

First line treatment of Chronic Hepatitis B in patients Monitor hepatic function after treatment
Swelling, erythema, pruritus, rash, stinging of Hypersensitivity to entecavir or to any active tubular secretion may increase serum
Entecavir 0.5 mg Tablet Baraclude who satisfy the criteria for treatment and require long- 0.5 mg once daily discontinuation. Patient with renal impairment. Liver
skin, burning sensation component of the product concentration of either entecavir or co-
term therapy or have a very high baseline viral load transplant recipients. Pregnancy and lactation
administered drug
Weakness, dizziness, insomnia, drowsiness,
Myotonic symptoms associated with cervical
numbness or trembling in the extremities, hepatic
Eperisone HCl 50 mg Tablet Myonal syndrome, periarthritis of shoulder and lumbago spastic 50 mg 3 times daily Hepatic disorders, drug hypersensitivity Not known Methocarbamol, tolperisone HCl
and renal dysfunction/ haematological changes,
paralysis
rashes, GI disturbances, urinary disorders
Patients treated with MAOIs or within 10 days of
Local irritation, after excessive use tolerance Anaesthetics, antidepressants,
Caution in infant below 3 months if irritant occurs it ceasing such treatment, intranasal ephedrine
Ephedrine 0.5% w/v Nasal Drops - Decongestion of the upper respiratory tract 2 drops 3 times daily. Maximum use for 1 week with diminished effect, rebound congestion, antihypertensives, alpha adrenergic blockers,
might narrow nasal passage should not be used in children under 6 years of
headache, nausea diuretic, MAOIs, methyldopa
age
Nervousness, anxiety, apprehension, fear,
tension, agitation, excitation, restlessness,
weakness, irritability, insomnia, dizziness,
By IM, SC or IV. Severe, acute bronchospasm : 12.5-25
lightheadness, vertigo, confusion, delirium,
mg. Further dosage should be determine by patient
hallucinations or euphoria. Throbbing headache, Anaesthesia with cyclopropane or halothane,
response. When used as a pressor agent : ADULT 25 - Should not be administered concomitantly with
respiratory difficulty, fever or a feeling of warmth, diabetes (for ephedrine injection).
Treatment of bronchial spasm in asthma, adjunct to 50 mg SC/IM. If necessary, a second IM dose of 50 mg Angina pectoris, chronic heart disease. Chronic use other sympathomimetic agents. Alpha and beta-
pallor, dryness of the nose and throat, precordial Hypersensitivity to ephedrine or other
Ephedrine HCl 30 mg/ml Injection - correct haemodynamic imbalances and treat or an IV dose of 25 mg may be given. Direct IV may cause an anxiety state. Prostatic hypertrophy, adrenergic blocking agents. Cyclopropane or
pain, sweating, mild epigastric distress, anorexia, sympathomimetic amines. Hypertension or other
hypotension in epidural and spinal anaesthesia injection, 10 - 25 mg may be given slowly. Maximum pregnancy halogenated hydrocarbons general anaesthetics.
nausea or vomiting. Acute urinary retention or cardiovascular disorders, obstetrical procedures
parenteral ADULT dose : 150 mg in 24 hours. CHILD : MAOIs
difficulty in urination. May initially decrease urine with maternal blood pressure, lactation
3 mg/kg or 100 mg/m2 SC or IV daily, in 4 - 6 divided
formation. Palpitation and tachycardia.
doses
Extrasystoles and potentially fatal arrhythmias
including ventricular fibrillation especially in
patients with organic heart disease
Myelosuppression, leukopenia,
thrombocytopenia, nausea, vomiting,
Pre-existing cardiac disease, renal or liver cardiotoxicity (arrhythmias, conduction
60 - 100 mg/m2 body area injected IV in 3 - 5 min, Hypersensitivity to anthracyclines, severe Paclitaxel and other anthracyclines, cimetidine,
Breast cancer, Non-Hodgkin's lymphoma, Leukaemia impairment, previous radiotherapy, elderly patients. disturbances, myopericarditis syndrome, dilated
Epirubicin 10 mg Injection Pharmorubicin repeated at 21 day intervals. CHILD: 50 mg/m2 over 6 cardiac impairment, recent myocardial infarct, cyclophophamide, 5-fluorouracil, heparin, live
(ALL induction), gastric cancer, ovarian cancer Avoid extravasation. Avoid cumulative doses beyond cardiomyopathy, congestive cardiac failure),
hours. Schedule depends on protocol severe liver dysfunction, pregnancy, lactation vaccines, trastuzumab, zidovudine
900 mg/m2 alopecia, mucositis, vesicant, rash,
hyperpigmentation of skin and nails, radiation
recall reaction, discolouration of urine
Myelosuppression, leukopenia,
thrombocytopenia, nausea, vomiting,
Pre-existing cardiac disease, renal or liver cardiotoxicity (arrhythmias, conduction
60 - 100 mg/m2 body area injected IV in 3 - 5 min, Hypersensitivity to anthracyclines, severe Paclitaxel and other anthracyclines, Cimetidine,
Breast cancer, Non-Hodgkin's lymphoma, Leukaemia impairment, previous radiotherapy, elderly patients. disturbances, myopericarditis syndrome, dilated
Epirubicin 50 mg Injection Adriamycin repeated at 21 day intervals. CHILD: 50 mg/m2 over 6 cardiac impairment, recent myocardial infarct, cyclophophamide, 5-fluorouracil, heparin, live
(ALL induction), gastric cancer, ovarian cancer Avoid extravasation. Avoid cumulative doses beyond cardiomyopathy, congestive cardiac failure),
hours. Schedule depends on protocol severe liver dysfunction, pregnancy, lactation vaccines, trastuzumab, zidovudine
900 mg/m2 alopecia, mucositis, vesicant, rash,
hyperpigmentation of skin and nails, radiation
recall reaction, discolouration of urine
Exacerbations of porphyria. Not recommended for Nausea and vomiting, abdominal pain, diarrhoea,
routine use prior to delivery of the placenta. Patients headache, dizziness, tinnitus, chest pain ,
Induction of labour, in cases of threatened Combined use of delavirdine and ergometrine
with heart disease, hepatic dysfunction, palpitations, bradycardia, dyspnoea,
Ergometrine Maleate 0.5 mg/ml Prevention and treatment of postpartum and spontaneous abortion, and in patients with a may cause elevated ergometrine serum
IM 200 - 1000 mcg and IV 250 - 500 mcg hypertension, mitral valve stenosis, obliterative hypertension, hypersensitivity reactions and
Injection postabortal haemorrhage due to uterine atony history of hypersensitivity or idiosyncratic concentration. Avoid concomitant use with
vascular disease, renal impairment, sepsis or ergotism has been reported. Cardiovascular
reactions antivirals like indinavir,saquinavir etc
venoarterial shunts. Hyperstimulation of the uterus effects, including arrhythmias and myocardial
during labor. Patients with calcium deficiency infarction and bronchospasm
Known or suspected central nervous system
Hypersensitivity to ertapenem or other drugs of
disorders including seizure history, history of Diarrheoa, infused vein complication, phlebitis,
Patient with confirm ESBL producing gram-negative ADULT: 1 g once daily. CHILD 3 month to 12 years: 15 same class, prior anaphylactic reactions to beta- Probenecid prolongs half-life of ertapenem.
Ertapenem 1 g Injection Invanz hypersensitivity to other beta-lactams, meningitis, headache, nausea, vomiting, seizure,
infection. Not for empirical therapy mg/kg twice daily. Not to exceed 1 g/ day lactams, hypersensitivity to amide type Valproic acid, uricosuric agents, typhoid vaccine
not recommended in the paediatric population due to anaphylaxis, hallucination
anaesthetics, lidocaine-IM injection
lack of sufficient cerebrospinal fluid penetration
Can increase plasma concentration of warfarin,
CHILD: mild to moderate infection: 30 - 50 mg/kg/day in Abdominal discomfort, mild allergic reaction; liver
theophylline, carbamazepine, cyclosporin,
Erythromycin Ethylsuccinate 200 mg/5 equally divided doses every 6 hours. For more severe dysfunction with or without jaundice; reversible
Erythrocin Treatment of susceptible bacterial infections Hepatic& renal impairment, myasthenia gravis Hypersensitivity, porphyria possibly phenytoin. Combination with ergotamine
ml Suspension infection this dose may be doubled. Doses may be hearing loss, prolonged Q-T interval, ventricular
increases risk of peripheral ischaemia. Caution
given 2 - 3 times a day arrhythmias, GI disturbances
when taken with terfenadine or astemizole

Abdominal discomfort, mild allergic reaction; liver
ADULT: 400 mg 6 hourly or 800 mg 12 hourly. theophylline, carbamazepine, cyclosporin,
Erythromycin Ethylsuccinate 400 mg dysfunction with or without jaundice; reversible
EES Treatment of susceptible bacterial infections Maximum 4 g/day. CHILD: 30 - 50 mg/kg/day in 2 - 4 Hepatic& renal impairment, myasthenia gravis Hypersensitivity, porphyria possibly phenytoin. Combination with ergotamine
Tablet hearing loss, prolonged Q-T interval, ventricular
divided doses increases risk of peripheral ischaemia. Caution
arrhythmias, GI disturbances

CHILD: mild to moderate infection: 30 - 50 mg/kg/day in Abdominal discomfort, mild allergic reaction; liver
Erythromycin Ethylsuccinate 400 mg/5 equally divided doses every 6 hours. For more severe dysfunction with or without jaundice; reversible
Eryped Treatment of susceptible bacterial infections Hepatic& renal impairment, myasthenia gravis Hypersensitivity, porphyria possibly phenytoin. Combination with ergotamine
ml Suspension infection this dose may be doubled. Doses may be hearing loss, prolonged Q-T interval, ventricular
given 2 - 3 times a day arrhythmias, GI disturbances
Only for treatment of i) certain forms of meningitis ii)
septicaemia not responding to usual antibiotics iii) Phlebitis; mild allergic reaction; liver dysfunction
ADULT& CHILD: 15 - 20 mg/kg/day in divided doses by Hypersensitivity, porphyria. Systemic: theophylline, carbamazepine, cyclosporin,
Erythromycin Lactobionate 500 mg mycoplasma pneumonia iv) infection with gram-positive with or without jaundice, reversible hearing loss,
Erythrocin IV infusion or intermittently by slow IV over 1 hour at Hepatic& renal impairment, myasthenia gravis concomitant use with ergot derivatives or possibly phenytoin. Combination with ergotamine
Injection organisms (e.g. tetanus, streptococcal infection) prolonged Q-T interval, ventricular arrhythmias,
intervals not more than 6 hourly. Maximum: 4 g/day cisapride increases risk of peripheral ischaemia. Caution
associated with Penicillin allergy, only when oral GI disturbances
erythromycin cannot be given
Abdominal discomfort, mild allergic reaction; liver
ADULT: 250 - 500 mg 6 hourly. CHILD: 30 - 50 dysfunction with or without jaundice; reversible
Erythromycin Stearate 250 mg Tablet Erythrocin Infections due to susceptible organism Hepatic& renal impairment, myasthenia gravis Hypersensitivity, porphyria possibly phenytoin. Combination with ergotamine
mg/kg/day in 4 divided doses hearing loss, prolonged Q-T interval, ventricular
arrhythmias, GI disturbances
To minimize the risk of hypertension, the rate of
i) ADULT by IV injection over 1-5 minutes, initially 50
increase in haemoglobin should not exceed 2
units/kg 3 times weekly adjusted according to response
g/dL/month. Measure haemoglobin levels once
in step of 25 units/kg 3 times weekly at interval of at
weekly until levels stabilise and periodically
least 4 weeks. CHILD initially as for adult. Maintenance, Dizziness, drowsiness, headache, arthralgia, Uncontrolled hypertension. In elective surgery
i) Treatment of anaemia associated with chronic renal thereafter, more frequent monitoring should be done
bodyweight under 10 kg usually 75-150 units/kg 3 times myalgia, increased blood pressure, hypertensive patients not participating in an autologous blood
failure. Dialysis patients who are haemoglobin less in patients with a baseline haemoglobin of more than
weekly, bodyweight 10-30 kg usually 60-150 units/kg 3 crisis, thrombocytosis, skin reactions at injection pre-donation programme who have severe Potentiated by hematinic agents. Dose
Erythropoietin Human Recombinant than 8 g or exhibiting symptoms of anaemia although 14 g/dL. History of seizures, gout, porphyria.
Eprex times weekly, bodyweight over 30 kg usually 30-100 site (SC). Hyperkalaemia, hyperphosphataemia, coronary, peripheral, arterial, carotid or adjustment required if given together with
10,000 IU/ml Injection haemoglobin more than 8 g and pre-transplant cases ii) Conditions associated with thrombotic or vascular
units/kg 3 times weekly ii) ADULT by SC injection (max. increased BUN and uric acid, increased cerebrovascular diseases including patients with ciclosporin
Anaemia in cancer (non-myeloid malignancies) with events, hepatic dysfunction. Monitor platelet count
1 ml per injection site), initially 150 units/kg 3 times creatinine (especially in chronic renal failure recent myocardial infarction or cerebrovascular
concomitant chemotherapy during first 8 week of therapy. Evaluate ferrous
weekly, increased if appropriate rise in haemoglobin not patients) accident
stores during therapy. Ferrous substitution is
achieved after 4 weeks to 300 units/kg 3 times weekly.
recommended for patients whose serum ferritin
Discontinue if inadequate response after 4 weeks at
levels are 15 g/dL. Ischaemic heart disease, chronic
higher dose
heart failure. Pregnancy and lactation
1000 IU/0.5ml Injection haemoglobin more than 8 g and pre-transplant cases ii) Conditions associated with thrombotic or vascular
higher dose
higher dose
higher dose
higher dose
Dizziness, headache, nausea, sweating,
i) 10 mg once daily; may be increased to max 20 mg Paradoxical anxiety, seizures, mania, diabetes, somnolence, insomnia, constipation, diarrhoea, MAOI, selegiline, lithium, tryptophan, agents that
daily. ii) Panic disorder with or without agoraphobia suicidal tendencies, hyponatraemia, haemorrhage, decreased appetite, sexual dysfunction, fatigue, may lower seizure threshold, St John's Wort,
:Initially 5 mg for the first week, thereafter increased to electroconvulsive therapy, reversible selective MAO- pyrexia, sinusitis, yawning, rash, Steven omeprazole, high doses of cimetidine, drugs
i) Treatment of major depressive episodes ii) Treatment 10 mg daily. May be further increased up to max 20 mg A inhibitors, serotonin syndrome, St John's Wort, Johnson Syndrome, rhinitis, blurred vision, nasal Concurrent use of MAOIs or within 14 days of metabolised by CYP2D6 and CYP2C19
Escitalopram 10 mg Tablet Lexapro
of panic disorder with or without agoraphobia daily, dependent on individual patient response. lactation, renal and hepatic function impairment, congestion, prolactinemia, dry mouth, decrease discontinuing MAOS treatment enzymes, alcohol, aspirin, NSAIDs, warfarin,
ELDERLY initially half adult dose, lower maintenance abnormal bleeding, avoid abrupt discontinuation, prothrombin, hepatic failure, hypoglycemia, carbamazepine, ketoconazole, linezolid,
dose may be sufficient. CHILD and ADOLESCENT may activate hypomania or mania, concomitant use hypokalemia, suicidal ideation, diaphoresis, tramadol, metoprolol, 5 HT agonist, gingko,
under 18 years not recommended of NSAIDs Syndrome of inappropriate antidiuretic hormone lamotrigine
secretion(SIADH)
Anaesthesia/surgery (myocardial depression), atrial

fibrillation (hypotension occurs more frequently in
these patients), avoid abrupt withdrawal, gradual
withdrawal over a period of 1 to 2 weeks is
recommended. Bronchospastic disease,
cerebrovascular insufficiency, congestive heart
failure, diabetes mellitus. Due to the potency and Hypotension, dizziness, somnolence, Hypersensitivity to esmolol products, Catecholamine-depleting drugs. Concomitant
By IV infusion usually within range of 50 - 200
Esmolol HCl 10 mg/ml Injection Brevibloc Tachycardia and hypertension in perioperative period rapid onset of clinical effects, small initial doses are confusions, headache, agitation, fatigue, nausea bradycardia, heart block, overt cardiac failure, use with verapamil (caution in patients with
mcg/kg/min
recommended, the infusion rate should be controlled and vomiting cardiogenic shock depressed myocardial function)
carefully, preferably with a volumetric infusion pump.
Elderly patients (hypotension occurs more frequently
in these patients), hyperthyroidism/thyrotoxicosis,
myasthenic conditions, peripheral vascular disease,
postoperative patients (hypotension occurs more
frequently in these patients) and renal disease
Exclude gastric malignancy prior to treatment.
Severe renal or hepatic insufficiency. Pregnancy;
Citalopram, imipramine, clomipramine,
lactation (discontinue). Long-term treatment should
Abdominal pain , constipation , diarrhoea , phenytoin, diazepam, ketoconazole ,
be kept under regular surveillance. Fructose
i)20mg daily for 4-8 weeks ii)40mg daily for 10 days in dyspepsia , flatulence , nausea , dizziness, Hypersensitivity to esomeprazole, in patients itraconazole, warfarin, effects on absorption,
i)Gastro-oesophageal reflux disease ii)H. pylori intolerance, glucose-galactose malabsorption or
Esomeprazole 20 mg Tablet Nexium combination with amoxicillin 1g twice daily or headache erythema multiforme , Stevens- with known hypersensitivity to any component of effects on hepatic metabolism/cytochrome P-450
eradication sucrase-isomaltase insufficiency. Monitoring when
clarithromycin 500mg twice daily Johnson syndrome, toxic epidermal necrolysis, the formulation pathways,clarithromycin and amoxicillin
initiating and ending concomitant treatment with
dermatitis (increase esomeprazole and 14-
warfarin.Severe liver impairment, Hypersensitivity
hydroxyclarithromycin plasma level)
reactions e.g., angioedema and anaphylactic
reaction/shock have been reported
dyspepsia , flatulence , nausea , dizziness, Hypersensitivity to esomeprazole in patients with itraconazole, warfarin,effects on absorption,
i) Acute erosive/ ulcerative oesophagitis ii) Non - i) 20- 40 mg once daily for 2-5 days ii) 80 mg by IV be kept under regular surveillance. Fructose
Esomeprazole 40 mg Injection Nexium headache erythema multiforme , Stevens- known hypersensitivity to any component of the effects on hepatic metabolism/cytochrome P-450
variceal upper gastrointestinal bleed bolus followed by 8mg/hour infusion for 72 hours intolerance, glucose-galactose malabsorption or
Johnson syndrome, toxic epidermal necrolysis, formulation pathways,clarithromycin and amoxicillin
sucrase-isomaltase insufficiency. Monitoring when
hydroxyclarithromy)
warfarin. Severe liver impairment
be kept under regular surveillance. Fructose
i)20mg daily for 4-8 weeks ii)40mg daily for 10 days in dyspepsia , flatulence , nausea , dizziness, Hypersensitivity to esomeprazole, in patients itraconazole, warfarin, effects on absorption,
i)Gastro-oesophageal reflux disease ii)H. pylori intolerance, glucose-galactose malabsorption or
Esomeprazole 40 mg Tablet Nexium combination with amoxicillin 1g twice daily or headache erythema multiforme , Stevens- with known hypersensitivity to any component of effects on hepatic metabolism/cytochrome P-450
eradication sucrase-isomaltase insufficiency. Monitoring when
clarithromycin 500mg twice daily Johnson syndrome, toxic epidermal necrolysis, the formulation pathways,clarithromycin and amoxicillin
warfarin.Severe liver impairment, Hypersensitivity
hydroxyclarithromycin plasma level)
reactions e.g., angioedema and anaphylactic
reaction/shock have been reported
Cholestyramine, colestipol or antacids containing
Essential Phospholipids Capsule Essentiale Nutritional supplement in liver disorders ADULT 1-2 capsules three times daily with meals Not Known Not known Not known
aluminium hydroxide
Hormone replacement therapy for oestrogen deficiency
Pregnancy and lactation, cancer of the breast,
Estradiol 1 mg & Norethisterone symptoms in women more than 1 year after History of thrombosis, hypertension, diabetes, liver Breast tenderness, headache, abdominal pain, Barbiturates, phenytoin, carbamazepine,
Activelle 1 tablet per day without interruption hormone dependent tumour, deep vein
Acetate 0.5 mg Tablet menopause and prevention of osteoporosis in post disorder, endometriosis nausea, flatulence, breast enlargement ketoconazole
thrombosis, acute or chronic liver disease
menopausal women
Known or suspected carcinoma of the breast,
Periodic general and gynaecological exam and
endometrial carcinoma or other hormone
mammogram should be instituted. Patients in the
dependent neoplasia. Acute or chronic liver
One tablet daily without pill-free interval, starting with 1 perimenopausal phase are advised to take non-
Estradiol 1 mg (14 tablet) & Estradiol Hormone Replacement Therapy for women with disease. History of liver disease where the liver
mg of Estradiol for first 14 days, followed by 1mg hormonal contraceptive precautions. Interruption of Breast tenderness, nausea, headache, oedema, Barbiturates, phenytoin, rifampicin,
1 mg with Dydrogesterone 10 mg (14 Femoston 1/10 disorders due to natural or surgically induced function tests have not returned to normal.
Estradiol with 10 mg Dydrogestrone daily for the next HRT 1 month before surgery should be considered. breakthrough bleedings, skin reactions carbamazepine
tablet) menopause with intact uteri History of venous thromboembolic diseases (e.g.
14 days Epilepsy, migraine, cardiac failure, hypertension,
deep venous thrombosis or pulmonary
porphyria, haemoglobinopathies, otosclerosis,
embolism). Abnormal genital bleeding. Known or
uterine leiomyomata, endometriosis, lactation
suspected pregnancy
Known or suspected carcinoma of the breast,
Periodic general and gynaecological exam and
endometrial carcinoma or other hormone
mammogram should be instituted. Patients in the
dependent neoplasia. Acute or chronic liver
perimenopausal phase are advised to take non-
i) Hormone replacement therapy for the relief of One tablet daily, taken continuously without disease. History of liver disease where the liver
Estradiol 1 mg with Dydrogesterone 5 hormonal contraceptive precautions. Interruption of Breast tenderness, nausea, headache, oedema, Barbiturates, phenytoin, rifampicin,
Femoston Conti symptoms due to oestrogen deficiency ii) Prevention of interruption. Should be used only in postmenopausal function tests have not returned to normal.
mg Tablet HRT 1 month before surgery should be considered. breakthrough bleedings, skin reactions carbamazepine
postmenopausal osteoporosis in women with a uterus women more than 12 month after menopause History of venous thromboembolic diseases (e.g.
Epilepsy, migraine, cardiac failure, hypertension,
deep venous thrombosis or pulmonary
porphyria, haemoglobinopathies, otosclerosis,
embolism). Abnormal genital bleeding. Known or
uterine leiomyomata, endometriosis, lactation
suspected pregnancy
Associated with adverse lipoprotein metabolism,
impairment of glucose tolerance, possible Severe liver disease, breast cancer (except
Barbiturates, phenylbutazone, hydantoins,
enhancement of mitotic activity in breast epithelial Headache, nausea, hypertension, myocardia metatastic disease), oestrogen dependent
Oestrogen replacement therapy - only those who 1 mg daily continuously or 21 day regimen with 1 week rifamcipin and ampicillin may impair action of the
Estradiol Valerate 1 mg Tablet Progynova tissue. Hypercoagulability, familial infarction, thromboembolism, vaginal bleeding, neoplasia, known or suspected pregnancy,
cannot tolerate Premarin of tablet free interval drug. Requirements for oral antidiabetics and
hyperlipoproteinaemia, fluid retention, uterine breast tension, increase in body weight undiagnosed abnormal vaginal bleeding,
insulin can change
bleeding and mastodynia, impaired liver function and thromboembolic disorders
aspirin hypersensitivity (tartazine dye)
Known or suspected pregnancy, including use
for missed abortion or as a diagnostic test for
Changes in vaginal bleeding pattern, change in pregnancy. Oestrogen or progestin may cause
amount of cervical secretion, premenstrual-like- foetal harm when administered to a pregnant
syndrome, cystitis-like-syndrome, increase in woman. Known or suspected cancer of the
size of uterine leiomyomata, vaginal candidiasis, breast. Known or suspected oestrogen -
Asthma, epilepsy, migraine, hypertension, cardiac or amenorrhoea, changes in cervical erosion, dependent neoplasm, severe liver dysfunction,
Pre and post menopausal syndrome, primary and renal dysfunction, endometrial hyperplasia, nausea, cholestatic jaundice, changes in jaundice or severe pruritus during a previous
Estradiol Valerate 2 mg and Start on the 5th day of menstrual cycle - 1 tab daily for Rifampicin, barbiturates, phenytoin, rifampicin,
secondary amenorrhea, menstrual irregularities. metabolic bone diseases, endometrial cancer, breast appetite, vomiting, abdominal cramps, bloating, pregnancy, previous or existing liver tumours,
Norgestrel 500 mcg with Estradiol Progyluton 21 days then stop for 7 days. If patient forgets dose at phenylbutazone, ampicillin. Requirements for
Deficiency symptoms after oophorectomy or cancer, gall bladder disease, pancreatitis, lactation, increased incidence of gall bladder disease, existing or suspected hormone-dependent
Valerate 2 mg Tablet usual time, it should be taken within following 12 hours oral antidiabetics and insulin can change
radiological castration for noncarcinomatous disease surgery, liver disorders, enlargement of uterine pancreatitis. Headache, dizziness, mental tumours of uterus or mammae. Severe diabetes
fibromyomata depression, nervousness, migraine. Increase or with vascular changes, previous or existing
decrease in weight, oedema, changes in libido, thromboembolic processes, endometriosis,
fatigue, backache, reduced carbohydrate disturbances of lipometabolism, a history of
tolerance, aggravation of porphyria, pyrexia, herpes gestationis, otosclerosis with
anaphylactoid reactions deterioration during previous pregnancies, Dubin-
Johnson syndrome, Rotor syndrome, sickle-cell
Injection site reactions, serious and fatal anemia
i) Moderately to severe rheumatoid arthritis as History of recurring or chronic infections, underlying infections due to bacteria, mycobacteria
monotherapy or in combination with methotrexate i) Rheumatoid arthritis: ADULT: 25 mg twice weekly at conditions which may predispose patients to (including TB), viruses and fungi, worsening of
(MTX) in patients with inadequate response to MTX intervals of 72-96 hours. ii) Polyarticular juvenile infections, blood dyscrasias, preexisting or recent CHF, abdominal pain, vomiting, multiple
alone. ii) Active polyarticular-course juvenile chronic idiopathic arthritis CHILD: more than 4 years: 0.4 mg/kg onset of CNS demyelinating disease or patients at sclerosis, cough, rhinitis, anemia, leukopenia, Sepsis or risk of sepsis, serious active infections,
Etanercept 25 mg Injection Enbrel arthritis in children 4-17 years with inadequate body weight twice weekly at intervals of 72-96 hours increased risk of developing demyelinating disease, neutropenia, pancytopenia, thrombocytopenia, including chronic or localized infections, Anakinra, sulfasalazine and live vaccines
response to, or who have proved intolerant of MTX. iii) and over. Maximum dosage: 25 mg. iii) Psoriatic CHF. Discontinue if serious infection or serious autoimmune hepatitis, optic neuritis, allergic pregnancy and lactation, known hypersensitivity
Psoriatic arthritis as monotherapy or in combination arthritis: ADULT: initially 25-50 mg twice weekly for up allergic/anaphylactic reaction develops. Avoid reactions, autoantibody formation; fever;
with MTX in patients inadequate response to MTX to 12 weeks then reduced to 25 mg twice weekly. concurrent administration with anakinra and live pruritus,; infections (including upper respiratory
alone. vaccines. Pregnancy and lactation tract infections, bronchitis, cystitis, skin
infections)
Generally well tolerated but may provoke
ADULT & CHILD more than 13 years: Initial treatment: reversible retrobulbar neuritis with a reduction of
15 mg/kg as a single daily dose 24 hourly. Retreatment: Reduced visual acuity. Reduced dosage in impaired visual acuity, central scotoma& green-red colour
Optic neuritis; history of previous adverse effects
Ethambutol HCl 200 mg Tablet Myambutol Tuberculosis 25 mg/kg/day as a single dose 24 hourly. Concurrent renal function. May precipitate attack of gout. Ocular blindness, allergic rashes, GI disturbances, Aluminium hydroxide, ethionamide
with ethambutol
anti-TB drug required. After 60 days, decrease to 15 examination is recommended jaundice, peripheral neuritis, confusion,
mg/kg body weight as single dose 24 hourly hallucinations, joint pain, fever, malaise,
headache, dizziness, anorexia& abdominal pain
Generally well tolerated but may provoke

ADULT & CHILD more than 13 years: Initial treatment: reversible retrobulbar neuritis with a reduction of
15 mg/kg as a single daily dose 24 hourly. Retreatment: Reduced visual acuity. Reduced dosage in impaired visual acuity, central scotoma& green-red colour
Optic neuritis; history of previous adverse effects
Ethambutol HCl 400 mg Tablet Myambutol Tuberculosis 25 mg/kg/day as a single dose 24 hourly. Concurrent renal function. May precipitate attack of gout. Ocular blindness, allergic rashes, GI disturbances, Aluminium hydroxide, ethionamide
with ethambutol
anti-TB drug required. After 60 days, decrease to 15 examination is recommended jaundice, peripheral neuritis, confusion,
mg/kg body weight as single dose 24 hourly hallucinations, joint pain, fever, malaise,
headache, dizziness, anorexia& abdominal pain
Hypersensitivity to iohexol/iopromide products,

Ether Solvent - To remove adhesive plaster from the skin Dose depending on the route and procedure Not known Not known intrathecal corticosteroids, immediate repeat Not known
myelography, local or systemic infection
Blood dyscrasias, agranulocytosis, aplastic
anaemia, drug-induced eosinophilia, leukopenia,
pancytopenia, ataxia, headache, nausea,
Isoniazid may increase the serum concentration
Patients with mixed seizure disorders, ethosuximide vomiting, gastrointestinal disturbances, weight
ADULT: Initially, 500 mg daily. Increased by 250 mg at of ethosuximide, leading to toxicity.
therapy when used alone may increase the loss, drowsiness, dyskinesia, depression,
intervals of 4-7 days to usual dose of 1-1.5 g daily. Antipsychotics, antidepressants, MAOIs and
incidence of grand mal seizures, avoid abrupt rashes, headache, fatigue, lethargy, dizziness,
Maximum: Up to 2 g, under strict supervision. CHILD: mefloquine may antagonise anticonvulsant
withdrawal, liver and renal disease, patients with hiccup and mild euphoria, more rarely, psychotic
Greater than or equal to 6 years: Same as adult dose; Hypersensitivity to succinimides. Pregnancy and effects of ethosuximide. Plasma concentration of
Ethosuximide 250 mg/5 ml Syrup Zarontin Absence seizures potentially fatal blood dyscrasias. Hepatic or renal states, hepatic and renal changes and
less than 6 years: Initially, 250 mg daily. Increased lactation ethosuximide may be reduced by
impairment, porphyria. Complete blood cell count, haematological disorders. Systemic lupus
gradually to usual dose of 20 mg/kg daily. Maximum: carbamazepine, phenobarbital, phenytoin and
liver function tests and urinalysis should be erythematous, Stevens-Johnson syndrome,
Children greater than or equal to 6 years: Same as primidone and affected by valproate.
performed periodically. May impair ability to drive or erythema multiforme. Gum hypertrophy, swelling
adult dose; less than 6 years: Up to 1 g Chloroquine or hydroxychloroquine may
operate machinery of tongue, irritability, hyperactivity, sleep
increase risk of convulsions
disturbances, night terrors, inability to
concentrate, aggressiveness, increased libido,
myopia, vaginal bleeding, seizure
Ethyl chloride is highly flammable and mixtures of
the gas with 5% to 15% of air are explosive; never
use it in the presence of an open flame or near
electric cautery equipment. Caution should be taken
to avoid frostbite; when used for cryotherapy, protect
Transient hypertension, narcosis, vomiting and
adjacent skin with petrolatum. Inhalation of ETHYL
coma. Thawing of frozen tissue after surgery Hypersensitivity to ethyl chloride products and
For minor surgical procedures including lancing boils, CHLORIDE can produce narcosis or even fatal
Spray to affected area at a distance of about 30cm until may be painful. Chemical frostbite may occur vascular impairment of the extremities.
Ethyl Chloride Spray - incision and drainage of small abscesses, pain due to coma with respiratory or cardiac arrest. Cover eyes, Cisatracurium, St John's Wort
a fine white film is produced following prolonged spraying onto the skin. Porphyria. Application on broken skin or mucous
athletic injuries and pain due to injection administration nose and mouth if spraying near the face.To protect
Nephrotoxicity or hepatotoxicity (long-term membranes
against tissue sloughing, cover the skin adjacent to
exposure)
the area being treated with petrolatum. Avoid spilling
the liqd on the skin. Freezing may also distort the
histological structure of biopsy specimens. Highly
flammable. Avoid inhalation when used as local
anaesthesia
Not for administration by prolonged infusion due to
hazarads of prolonged suppression of endogenous
Hypotension, adrenal suppression, myoclonus,
cortisol and aldosterone production, severe asthma,
transient skeletal movements, uncontrolled eye
severe cardiovascular disease. Not to use for Fentanyl, verapamil, St. John'swort.
Induction of general anaesthesia for haemodynamically CHILD greater 10 years and ADULT: 0.15 - 0.3 mg/kg movements, hiccups. Excitatory phenomena eg, Hypersensitivity to etomidate. Reduced or at risk
Etomidate 20 mg/10 mg Injection Etomidate Lipuro maintenance of anaesthesia. Opioid analgesics or Antipsychotics, sedatives or opioids; calcium-
unstable patients ELDERLY: 0.15 mg/kg - 0.2 mg/kg involuntary myoclonic muscle movements, of reduced adrenocortical function. Porphyria
benzodiazepines may be given as premedications to channel blockers
convulsions; hypersensitivity reactions, pain on
reduce risk of convulsions. Pre-existing epilepsy.
injection; postoperative nausea and vomiting
Elderly and child less than 10 years. Pregnancy and
lactation.
i) 50 mg/m2 in 2 divided doses/day for 21 days. Rest 1
i) For palliative treatment of children with
week and restart. Usually for 6 courses ii) 50 mg daily Myelosuppression, nausea and vomiting, Ciclosporin, calcium antagonists, methotrexate,
neuroblastoma, germ cell tumour, leukaemia ii) For Use with caution in hepatic or renal impairment, Hypersensitivity to podophyllins, severe hepatic
Etoposide 100 mg Capsule Vepesid for 21 days every 28 days or 100 mg daily for 14 days alopecia, hypersensitivity reaction, radiation warfarin. Increased risk of infection by the live
elderly patients with acute myeloid leukemia and myelosuppression dysfunction, pregnancy, lactation
every 3 weeks. Doses for indications: refer to specific recall reaction, secondary malignancy vaccine
myelodysplasia (palliative)
protocols
i) CHILD: 60-120 mg/m2/day by IV for 3 - 5 days every
i) For treatment of children with solid tumours, juvenile 3 - 6 weeks depending on protocols ii) Maintenance or Use with caution in hepatic or renal impairment,
Myelosuppression, nausea and vomiting,
myelomonocytic leukemia (JMML) and Langerhan cell palliative chemotherapy for elderly acute myeloid myelosuppression. Administer intravenously over 30 Ciclosporin, calcium antagonists, methotrexate,
alopecia, hypersensitivity reaction, local Hypersensitivity to podophyllins, severe hepatic
Etoposide 100 mg/5 ml Injection Vepesid histiocytosis ii) Leukaemia, lymphoma iii) Testicular leukemia, consolidation therapy for acute lymphoblastic to 60 minutes to reduce risk of hypotension. warfarin. Increased risk of infection by the live
inflammatory reaction at site of injection, dysfunction, pregnancy, lactation
cancer, lung cancer, gestational trophoblastic disease, leukemia, stem cell mobilization (Refer to protocol) iii) Anaphylaxis following IV administration to be vaccine
radiation recall reaction, secondary malignancy
gastric cancer, sarcoma 100 mg/m2 by IV every other day for 3 doses repeated anticipated and treated appropriately
every 3-4 weeks
i) 50 mg/m2 in 2 divided doses/day for 21 days. Rest 1
i) For palliative treatment of children with
week and restart. Usually for 6 courses ii) 50 mg daily Myelosuppression, nausea and vomiting, Ciclosporin, calcium antagonists, methotrexate,
neuroblastoma, germ cell tumour, leukaemia ii) For Use with caution in hepatic or renal impairment, Hypersensitivity to podophyllins, severe hepatic
Etoposide 25 mg Capsule Vepesid for 21 days every 28 days or 100 mg daily for 14 days alopecia, hypersensitivity reaction, radiation warfarin. Increased risk of infection by the live
elderly patients with acute myeloid leukemia and myelosuppression dysfunction, pregnancy, lactation
every 3 weeks. Doses for indications: refer to specific recall reaction, secondary malignancy vaccine
myelodysplasia (palliative)
protocols
Patients who experienced asthma, urticaria or
i) OA: 60 mg once daily. RA: 90 mg once daily ii & iii) Small increase in blood pressure, increased risk
Bleeding disorders, liver disease, renal impairment , allergic type of reaction after taking aspirin or
i)Acute and chronic treatment of signs and symptoms Acute gouty arthritis and acute pain: 120 mg once daily of thrombotic complication, headache, dizziness,
hypertension, recent myocardial infarct, NSAIDs, acute peptic ulcer, severe renal or Warfarin, ACEIs, lithium, methotrexate, oral
Etoricoxib 120 mg Tablet Arcoxia of osteoarthritis (OA) and rheumatoid arthritis (RA) (Given the exposure to COX-2 inhibitors, doctors are fatigue, insomnia, nausea, vomiting, diarrhoea,
cardiovascular disease, hyperlipidaemia, diabetes, hepatic disease,ischaemic heart disease and contraceptives, rifampicin, aspirin, SSRIs
ii)Acute gouty arthritis iii)Acute pain advised to use the lowest effective dose for the shortest heartburn, taste disturbance, decreased appetite
smoking, peripheral arterial disease stroke, hypertensive patient whose blood
possible duration of treatment) and flatulence
pressure is not under control
Diaphoresis, hot sweats, nausea, arthralgia,
Treatment of post-menopausal women with advanced Coadministration with oestrogen-containing Drugs metabolised via CYP3A4, drug with
headache, insomnia, fatigue, heart failure, Hypersensitivity to the exemestane or to any of
Exemestane 25 mg Tablet Aromasin breast cancer whose disease has progressed following 25 mg once daily products, pregnancy, premenopausal women, narrow therapeutic index, oestrogen-containing
myocardial infarction, fracture of bone, the excipents
tamoxifen and non-steroidal aromatase inhibitors hepatic or renal impairment medicines
cerebrovascular accident
Myalgia, headache, upper respiratory infection,
hepatotoxicity, anaphylaxis, angioedema drug-
Itraconazole, ketoconazole, erythromycin,
induced myopathy, rhabdomyolysis, abdominal
Unexplained muscle pain, tenderness or weakness, Hypersensitivity to ezetimibe or simvastatin or clarithromycin, HIV protease inhibitors,
pain, diarrhoea, fatigue, thrombocytopenia,
Ezetimibe 10 mg & Simvastatin 20 mg heavy alcohol use, past history of liver disease or any of its components. Active liver disease or gemfibrozil, niacin, cyclosporine, danazol,
Vytorin Primary hypercholesterolemia Usual starting dose: 10/20 mg/day hepatitis, hypersensitivity reactions including
Tablet current moderate to severe hepatic insufficiency, unexplained persistent elevations in serum amiodarone, verapamil, cholestyramine,
rash and angioedema, pancreatitis, nausea,
major surgery, renal insufficiency transaminases, pregnancy, lactation diltiazem, fibrates, grapefruit juice, coumarin
anaemia, constipation, asthenia, jaundice,
derivatives, antacids
muscle cramps, dizziness, paresthesia,
peripheral neuropathy, alopecia, pruritus
i) Co-administration with statins for patients who have
chronic heart disease or are chronic heart disease
Children under 10 years old, moderate to severe Avoid co-administration with fibrates.
equivalent or familial hypercholesterolaemia with target 10 mg once daily. Not recommended for children less Abdominal pain, arthralgia, back pain, cough,
Ezetimibe 10 mg Tablet Ezetrol hepatic insufficency, myopathy, pregnancy and Hypersensitivity to ezetimibe, active liver disease Cholestyramine, fibrates, cyclosporin
LDL-C not achieved by maximum dose of statins ii) than 10 years old diarrhoea, fatigue, headache, sinusitis
lactation or persistently elevated liver enzymes
Monotherapy in patients with documented biochemical
intolerance to statins
Dose varies according to the patient and the
circumstances of the bleeding. i) Mild haemorrhage:
initial dose of 30 units/kg body weight. ii) Moderate Allergic reactions, mild chills, nausea, Hypersensitivity to Factor IX or any component
Prevention and control of bleeding in patients with Risk of thrombosis. Use with caution in patients with Coadministeration with aminocaproic acid may
Factor IX Injection Alphanine,profilnine haemorrhage: initial dose of 50 units/kg iii) Major fever,nausea, vomiting, headache, flushing, of the formulation. Disseminated intravascular
factor IX deficiency due to haemophilia B liver dysfunction increase risk for thrombosis
haemorrhage/surgery: Initial dose of 75 - 100 units/kg. intravascular coagulation,thrombosis coagulation
Half of these doses may be repeated after 18-24 hrs if
necessary.
Advanced atherosclerotic disease: increased risk of
thrombotic events. Concomitant use of activated or
Initially 4.5 KIU (90 mcg)/kg body weight IV bolus over nonactivated prothrombin complex concentrates:
2-5 minutes, followed by 3-6 KIU (60-120 mcg)/kg body increased risk of thrombotic events .Crush injury; Rash, itching, nausea, fever, headache, malaise,
Treatment of bleeding episodes and prevention of
Factor VIIa (Recombinant) eptacog weight depending on type & severity of haemorrhage or disseminated intravascular coagulation diaphoresis, changes in blood pressure,renal
excessive bleeding in connection with surgery in Hypersensitivity to Factor VII or any component Simultaneous use of prothrombin complex
alfa (activated) 60 KIU (1.2 mg) Novoseven surgery performed. Dosing interval: initially 2-3 hour to (DIC),Septicemia: increased risk of thrombotic failure, cerebrovascular disorder, angina
patients with inherited or acquired haemophilia with of the formulation concentrates, activated or not should be avoided
Injection obtain haemostasis and until clinically improved. If events .Elderly, non-hemophilia, intracerebral pectoris, atrial arrhythmia, circulatory shock,
inhibitors to coagulation factors VIII or IX
continued therapy is needed, dose interval can be hemorrhage patients: increased risk of arterial hemorrhage, hemarthrosis
increased successively to every 4, 6, 8 or 12 hours thromboembolic adverse events, including
myocardial ischemia, myocardial infarction, cerebral
ischemia and or infarction.
Hepatic disease ,newborn ,non-hemophilic patients Complication of infusion, headache, flushing,
Bleeding episodes resulting from coagulation
Treatment and prophylaxis of hemorrhage in ,thrombosis risk factors .Risk of disseminated fever, chills, change in blood pressure or pulse
Factor VIII Inhibitor Bypassing Activity factor deficiencies , disseminated intravasular
Feiba hemophilia A, B and non-hemophiliacs with acquired Individualized dosage intravascular coagulation, liver damage, CHD, acute rate ,myocardial infarction , hives ,disseminated Antifibrinolytics, tranexamic acid
Injection coagulation , fibrinolysis ,normal coagulation
inhibitors to factor VIII, IX, XI thrombosis and or embolism. Pregnancy and intravascular coagulation, DIC, thromboembolic
mechanism
lactation disorder , anaphylactoid reaction
Dose varies according to the patient and the

circumstances of the bleeding. i) Mild to moderate:
Risk of thrombosis and transmission of infection,
Usually a single dose of 10-15units/kg. ii) More serious Allergic reactions (chills, urticaria, fever),
Prevention and control of bleeding in patients with pregnancy. Intravascular haemolysis after Disseminated intravascular coagulation,
Factor VIII Injection Alphanate,Hemofil M haemorrhage/minor surgery:Initially 15-25 units/kg headache, intravascular haemolysis, increased Not known
factor VIII deficiency due to classical haemophilia A large/frequently repeated doses in patients with underlying thrombosis
followed by 10-15 units/kg every 8 - 12 hours if required body temp, development of factor VIII antibodies
blood groups A,B, or AB
iii) Severe haemorrhage/major surgery: Initial : 40 - 50
units/kg followed by 20 - 25 units/kg every 8-12 hrs.
Renal insufficiency, uncompensated diabetes,
Dose to be individualised. ADULT usual lipid Fever, hypertriglyceridaemia, shivering, chills, Pathological hyperlipidaemia, severe liver
Fat Emulsion 10% Injection - Source of lipid in patients needing IV nutrition certain forms of liver insufficiency (monitor liver Not known
requirement 2-3 g/kg/day. INFANT 0.5 - 1 g/kg/day nausea and vomiting damage and acute shock
function), metabolic disorders and sepsis
Renal insufficiency, uncompensated diabetes,
Dose to be individualised. ADULT usual lipid Fever, hypertriglyceridaemia, shivering, chills, Pathological hyperlipidaemia, severe liver
Fat Emulsion 20% for IV Infusion Intralipid Source of lipid in patients needing IV nutrition certain forms of liver insufficiency (monitor liver Not known
requirement 2-3 g/kg/day. INFANT 0.5-1 g/kg/day nausea and vomiting damage and acute shock
function), metabolic disorders and sepsis
Hypersensitivity to felodipine or other calcium
Beta-adrenergic blockers, cyclosporin,
Flushing, headache, palpitations, dizziness, channel blockers, symptomatic hypotension,
Initiate at 5 mg once daily. Usual dose, 5 - 10 mg once Rarely precipitate significant hypotension which can fluconazole, itraconazole, ketoconazole,
Felodipine 10 mg Tablet Plendil Hypertension fatigue. Ankle swelling (appears to be dose- peripheral vascular disease, persistent
daily in the morning lead to myocardial ischaemia magnesium, oral anticoagulants, phenobarbital
related). Mild gingival hyperplasia dermatologic reactions, cardiovascular arterial
and saquinavir
disease and congestive haeart failure
Hypersensitivity to felodipine or other calcium
Beta-adrenergic blockers, cyclosporin,
Flushing, headache, palpitations, dizziness, channel blockers, symptomatic hypotension,
Initiate at 5 mg once daily. Usual dose, 5 - 10 mg once Rarely precipitate significant hypotension which can fluconazole, itraconazole, ketoconazole,
Felodipine 5 mg Tablet Plendil Hypertension fatigue. Ankle swelling (appears to be dose- peripheral vascular disease, persistent
daily in the morning lead to myocardial ischaemia magnesium, oral anticoagulants, phenobarbital
related). Mild gingival hyperplasia dermatologic reactions, cardiovascular arterial
and saquinavir
disease and congestive haeart failure
Local skin reaction, constipation, nausea,
vomiting, drowsiness, dry mouth, psychomimetic
Elderly, neonates, children, obstetric effect (dysphoria, hallucination, nightmare),
patients,hepatic/renal dysfunction, pulmonary urinary retention, respiratory depression
As a second line drug in the management of chronic ADULT and CHILD over 2 years previously treated with CNS depressant, including opiods, sedatives,
disease, increased intracranial pressure, pregnancy, (clinically significant respiratory depression is a Hypersensitivity, acute pain, raised intra-cranial
severe cancer pain not responding to non-narcotic a strong opioid analgesic, initial dose based on hypnotics, general anaesthetics, phenothiazines,
lactation. Avoid exposing patch to direct heat.Not for rare occurance in patients whose opioid doses pressure, respiratory depression and biliary colic
Fentanyl 12 mcg/h Trandermal Patch Durogesic analgesic. Not to be used in opiod naive patients.The previous 24-hour opioid requirement (consult product tranquilizers, skeletal muscle relaxants, sedating
acute or post-op pain. COPD or other pulmonary have been titrated against pain), physical (these conditions are not contra-indicated in
use is to be restricted to pain specialists, palliative literature). If necessary dose should be adjusted at 72- antihistamines and alcohol beverages: additive
disease, bradyarrhythmias, brain tumour, impaired dependence (physical dependence can be patients who are terminally ill)
medicine specialists and oncologists hour intervals in steps of 12-25 mcg/hr depressant effects, ritonavir
consciousness or coma. Withdraw gradually. May prevented by gradual withdrawal of
impair ability to drive or operate machinery. Fever opioids).Hypoventilation, somnolence, confusion,
hypotension, bradycardia, headache, pruritus,
sweating, rash, erythema
Patients who have not previously received a strong
opioid analgesic, initial dose , one 25 mcg/hour patch to CNS depressant, including opiods, sedatives,
As a second line drug in the management of chronic disease, increased intracranial pressure, pregnancy, (clinically significant respiratory depression is a Hypersensitivity, acute pain, raised intra-cranial
be replaced after 72 hours. Patients who have received hypnotics, general anaesthetics, phenothiazines,
cancer pain. The use is to be restricted to pain lactation. Avoid exposing patch to direct heat.Not for rare occurance in patients whose opioid doses pressure, respiratory depression and biliary colic
Fentanyl 25 mcg/h Transdermal Patch Durogesic a strong opioid analgesic, initial dose based on tranquilizers, skeletal muscle relaxants, sedating
specialists, palliative medicine specialists and acute or post-op pain. COPD or other pulmonary have been titrated against pain), physical (these conditions are not contra-indicated in
previous 24 hours opioid requirement (oral morphine antihistamines and alcohol beverages : additive
oncologists. disease, bradyarrhythmias, brain tumour, impaired dependence (physical dependence can be patients who are terminally ill).
sulphate 90 mg over 24 hours = one 25 mcg/hour depressant effects, ritonavir.
patch). Not recommended in children.
sweating, rash, erythema
Patients who have not previously received a strong
opioid analgesic, initial dose , one 25 mcg/hour patch to CNS depressant, including opiods, sedatives,
As a second line drug in the management of chronic disease, increased intracranial pressure, pregnancy, (clinically significant respiratory depression is a Hypersensitivity, acute pain, raised intra-cranial
be replaced after 72 hours. Patients who have received hypnotics, general anaesthetics, phenothiazines,
cancer pain. The use is to be restricted to pain lactation. Avoid exposing patch to direct heat.Not for rare occurance in patients whose opioid doses pressure, respiratory depression and biliary colic
Fentanyl 50 mcg/h Transdermal Patch Durogesic a strong opioid analgesic, initial dose based on tranquilizers, skeletal muscle relaxants, sedating
specialists, palliative medicine specialists and acute or post-op pain. COPD or other pulmonary have been titrated against pain), physical (these conditions are not contra-indicated in
previous 24 hours opioid requirement (oral morphine antihistamines and alcohol beverages : additive
oncologists disease, bradyarrhythmias, brain tumour, impaired dependence (physical dependence can be patients who are terminally ill)
sulphate 90 mg over 24 hours = one 25 mcg/hour depressant effects, ritonavir.
patch). Not recommended in children.
sweating, rash, erythema.
Amiodarone : cardiac toxicity (low cardiac
output). Azole antifungals, macrolide antibiotics :
Dose should be individualized according to age, body increased or prolonged opioid effects (CNS
weight, physical status, underlying pathological depression, respiratory depression). Beta-
conditions and type of surgery and anaesthesia. With adrenergic blockers, calcium channel blockers :
Children more than 2 years, asthma, respiratory
spontaneous respiration, 50 - 200 mcg, then 50 mcg Respiratory depression, apnoea, muscle rigidity, severe hypotension. Carbamazepine :
Analgesia during operation, relief of pain in the depression, head injury, patients receiving
every 20 - 30 minutes. as required. With assisted Pulmonary function impairment, liver/kidney bradycardia, cardiac dysrhythmia, decreased plasma concentrations of fentanyl.
Fentanyl Citrate 50 mcg/ml Injection Fentanyl immediate postoperative period. Adjunct in MAOIs within previous 14 days, hypersensitivity,
respiration: 0.3 - 3.5 mg, then 100 - 200 mcg as dysfunction, cardiac arrhythmias, myasthenia gravis tachyarrhythmia, chest pain, hypertension, Diazepam : significant decreases of mean
maintenance of general / regional anaesthesia. increased intracranial pressure, pregnancy and
required up to 600 mcg. CHILD:Child with spontaneous hypotension, hypoventilation, neutropenia arterial pressure and systemic vascular
lactation
respiration: 3 - 5 mcg/kg, then 1 mcg/kg as required. resistance. Naltrexone : precipitation of opioid
Child with assisted ventilation : 10 - 15 mcg/kg, then 1 - withdrawal symptoms. Phenytoin : decreased
3 mcg/kg as required plasma concentrations of fentanyl. Protease
inhibitors : increased risk of fentanyl toxicity
(CNS depression, respiratory depression).
Concurrent administration with Vitamin C
increases absorption of oral iron. Given with
tetracycline, decreased tetracycline and iron
Haemochromatosis, haemoglobinopthies, existing Abdominal cramps, nausea, vomiting, diarrhoea Not to be given in patient receiving repeated effectiveness. Fluoroquinolones, levodopa,
Ferric Ammonium Citrate 800 mg/10 CHILD up to 1 year 5 ml, 1 - 5 years 10 ml, taken well gastrointestinal diseases. Should be well diluted with or constipation, dark stools, heartburn, blood transfusion. Haemochromatosis, methyldopa, penicillamine, antacids, H2
- Prevention and treatment of iron-deficiency anaemias
ml Paediatric Mixture diluted with water water and drink through a straw to prevent teeth temporary teeth staining and discolouration of haemolytic anaemia, known hypersensitivity to blockers, proton pump inhibitors,
discoloration urine iron salts chloramphenicol. Dairy foods, decreased iron
bioavailability. Aluminium, calcium or magnesium
containing products, decreased iron
effectiveness
Concurrent administration with Vitamin C
increases absorption of oral iron. Given with
tetracycline, decreased tetracycline and iron
Avoid in patients with peptic ulcer, enteritis, receiving
Abdominal cramps, nausea, vomiting, diarrhoea effectiveness. Fluoroquinolones, levodopa,
frequent blood transfusions or ulcerative colitis.
Prophylactic 200 mg daily. Therapeutic 200 mg 2 times or constipation, dark stools, heartburn, Haemochromatosis, haemolytic anaemia, known methyldopa, penicillamine, antacids, H2
Ferrous Fumarate 200 mg Tablet - Prevention and treatment of iron-deficiency anaemias Administration of iron for more than 6 months should
daily. CHILD up to 6 years 80-140 mg 2 times daily temporary teeth staining and discolouration of hypersensitivity to iron salts blockers, proton pump inhibitors,
be avoided except in patients with continuous
urine chloramphenicol. Dairy foods, decreased iron
bleeding or menorrhagia
bioavailability. Aluminium, calcium or magnesium
containing products, decreased iron
effectiveness
Chest pain, fever, hypersensitivity reaction,
alopecia. Bone pain, flu-like symptoms, nausea
i) Reduction in the duration of neutropenia and
i) Adult: SC or IV 5 mcg/kg/day. Initiation: 24 - 72 hours Secondary acute myeloid leukemia. Perform regular and vomiting, adult respiratory distress
incidence of febrile neutropenia in cytotoxic
after chemotherapy. Duration: Until a clinically white blood cell, platelet and hematocrit count syndrome, sickle cell crisis, hepatomegaly, Hypersensitivity to filgrastim, severe congenital
chemotherapy for malignancy except chronic myeloid
Filgrastim (G-CSF) 30 MU/ml Injection Neupogen adequate neutrophil recovery is achieved (absolute throughout therapy. Monitor ANC and spleen size. splenic enlargement, transient hypotension, neutropenia (Kostmann's syndrome) with Vincristine, topotecan, lithium
leukemia and myelodysplastic syndrome ii)
neutrophil count of at least 1 x 109/L on 2 consecutive Bone marrow infiltrating infections or malignancy. epistaxis urinary abnormalities (dysuria, abnormal cytogenetics
Haemopoeitic stem cell transplantation (HSCT)/stem
days) ii) Refer to protocol Sickle cell disease. Pregnancy and lactation proteinuria, hematuria), exacerbation of
cell harvesting
rheumatoid arthritis, thrombocytopenia, anemia
raised uric acid
Chest pain, fever, hypersensitivity reaction,
alopecia. Bone pain, flu-like symptoms, nausea
i) Reduction in the duration of neutropenia and
i) ADULT: 5 mcg/kg/day by SC or IV. Initiation: 24 - 72 Secondary acute myeloid leukemia. Perform regular and vomiting, adult respiratory distress
incidence of febrile neutropenia in cytotoxic
hours after chemotherapy. Duration: Until a clinically white blood cell, platelet and hematocrit count syndrome, sickle cell crisis, hepatomegaly, Hypersensitivity to filgrastim, severe congenital
chemotherapy for malignancy except chronic myeloid
Filgrastim 30 MU in 0.5 ml Injection Neupogen adequate neutrophil recovery is achieved (absolute throughout therapy. Monitor ANC and spleen size. splenic enlargement, transient hypotension, neutropenia (Kostmann's syndrome) with Vincristine, topotecan, lithium
leukemia and myelodysplastic syndrome ii)
neutrophil count of at least 1 x 109/L on 2 consecutive Bone marrow infiltrating infections or malignancy. epistaxis urinary abnormalities (dysuria, abnormal cytogenetics
Haemopoeitic stem cell transplantation (HSCT)/stem
days) ii) Refer to protocol Sickle cell disease. Pregnancy and lactation proteinuria, hematuria), exacerbation of
cell harvesting
rheumatoid arthritis, thrombocytopenia, anemia
raised uric acid
Patients should be screened for prostatic carcinoma,
hepatic dysfunction, patients with a large residual
urinary volume or a severely diminished urinary flow
5 mg a day as a single dose. Clinical responses occur
rate should be monitored for obstructive uropathy
within 12 weeks - 6 months of initiation of therapy. Long- Sexual dysfunction, breast tenderness or Hypersensitivity to finasteride products, known or
Finasteride 5 mg Tablet Proscar Treatment and control of benign prostatic hyperplasia and may not be candidates for finasteride therapy, Not known
term administration is recommended for maximal enlargement suspected pregnancy
crushed tablets should not be handled by a woman
response
when she is pregnant or may potentially be pregnant
because of the possibility of absorption and the
subsequent potential risk to the male foetus
Gastrointestinal disturbances, vertigo, headache, Pyloric or duodenal obstruction, obstructive
mental confusion especially in elderly, intestinal lesions or ileus, achalasia,
Urinary frequency and incontinence, dysuria, urgency, ADULT: 200 mg 3 times daily. CHILD under 12 years Pregnancy and lactation, suspected glaucoma. May
Flavoxate HCl 100 mg Tablet Urispas drowsiness, fatigue and nervousness, gastrointestinal haemorrhage, obstructive Other antimuscarinic drugs
bladder spasm due to catheterisation not recommended affect ability to drive or operate machinery
tachycardia and palpitations, urticaria, uropathies of the lower urinary tract, children
eosinophilia and hyperpyrexia less than 12 years
Amiodarone; increased flecainide plasma levels;
reduce dose of flecainide
Congestive heart failure (CHF), patients with a left 50%.Cimetidine;increased bioavailability and half-
ventricular ejection fraction (LVEF) less than 40% life of flecainide.Cisapride, disopyramide,
may be particularly susceptible to the adverse verapamil;has negative inotropic effects;
cardiac effects (ie, worsening CHF, proarrhythmia). administer with flecainide only if benefit
i) Sustained monomorphic ventricular tachycardias ii) Elderly patients. Electrolyte imbalance (eg, hypo- or outweighs the risks. Coadministration with
Ventricular arrhythmias: 100 mg twice daily, maximum
Preexcited atrial fibrillation associated with Wolff- hyperkalemia) . Hepatic disease, increased Giddiness, dizziness, lightheadedness, visual Preexisting second- or third-degree AV block; flecainide is not recommended because of the
400 mg/day (usually reserved for rapid control or in
Parkinson White Syndrome iii) Reciprocating Atrio- mortality; flecainide should not be initiated in post- disturbances, nausea and vomiting. right bundle branch block when associated with increased risk of life-threatening cardiac
heavily built patients), reduced after 3 - 5 days if
Flecainide Acetate 100 mg Tablet Trambocor Ventricular tachycardias (AVT) associated with Wolff- myocardial infarction patients with asymptomatic or Proarrhythmia may occur in patients with a left hemiblock (unless a pacemaker is present); arrhythmias.Digoxin;Increased digoxin plasma
possible. Supraventricular arrhythmias: 50 mg twice
Parkinson White Syndrome iv) Supraventricular minimally symptomatic non-life threatening structural heart disease and or significant left presence of cardiogenic shock; hypersensitivity levels.Drugs that inhibit CYP2D6 (eg, quinidine,
daily, increased if required to maximum of 150 mg twice
tachycardias due to Intra-Atrio Ventricular Nodul ventricular arrhythmias. Increased pacemaker ventricular impairment to the drug ritonavir);Flecainide plasma concentrations may
daily
Reentry threshold, proarrhythmic events; new or worsened be elevated, increasing the risk of
arrhythmias, primarily at high serum levels . Renal toxicity.Propranolol;levels of either drug may be
disease . Sick sinus syndrome (Bradycardia- increased, additive negative inotropic effects.
Tachycardia syndrome) and slowing of cardiac Smoking;increased dosage may be
conduction required.Urinary acidifiers;effects of flecainide
may be decreased. Urinary alkalinizers;effects of
flecainide may be increased
i) Oropharyngeal candidiasis: 50 - 100 mg daily for 7 -
14 days (Maximum 14 days) except in severely
immunocompromised patients, treatment can be
i) Oropharyngeal candidiasis, atrophic oral candidiasis continued for longer periods. Atrophic oral candidiasis
associated with dentures, other candidal infections of associated with dentures: 50 mg daily for 14 days.
mucosa ii) Tinea pedis, corporis, cruris, versicolor and Other candidal infections of mucosa: 50 - 100 mg daily
dermal candidiasis iii) Invasive candidal & cryptococcal for 14 - 30 days. CHILD: 3 - 6 mg/kg on first day then 3
infections (including meningitis) iv) Prevention of mg/kg daily (every 72 hours in NEONATE up to 2 Known hypersensitivity to fluconazole or to
Nausea, abdominal pain, diarrhoea, flatulence; Warfarin, oral sulfonylureas, phenytoin,
Fluconazole 100 mg Capsule Diflucan relapse of cryptococcal meningitis in AIDS patients weeks old, every 48 hours in NEONATE 2 - 4 weeks Pregnancy, lactation, renal impairment related azole compounds, co-administration of
rash, headache rifampicin, cyclosporin, theophylline, cisapride
after completion of primary therapy v) Prevention of old) ii) 50 mg daily for 2 - 4 weeks, maximum 6 weeks terfenadine
fungal infections in immunocompromised patients iii) 400 mg initially then 200 - 400 mg daily for 6 - 8
considered at risk as a consequence of HIV infections weeks. CHILD: 6 - 12 mg/kg daily (every 72 hours in
or neutropenia following cytotoxic chemotherapy, NEONATE up to 2 weeks old, every 48 hours in
radiotherapy or bone marrow transplant NEONATE 2 -4 weeks old) iv) 100 - 200 mg daily v) 50 -
400 mg daily. CHILD: 3 - 12 mg/kg daily (every 72
hours in NEONATE up to 2 weeks old, every 48 hours
in NEONATE 2 - 4 weeks old)
i) 50 - 100 mg daily for 7 - 14 days (Maximum 14 days)
except in severely immunocompromised patients,
treatment can be continued for longer periods. Atrophic
i) Oropharyngeal candidiasis, atrophic oral candidiasis
oral candidiasis associated with dentures: 50 mg daily
associated with dentures, other candidal infections of
for 14 days. Other candidal infections of mucosa: 50 -
mucosa ii) Tinea pedis, corporis, cruris, versicolor and
100 mg daily for 14 - 30 days. CHILD: 3 - 6 mg/kg on
dermal candidiasis iii) Invasive candidal& cryptococcal
first day then 3 mg/kg daily (every 72 hours in
infections (including meningitis) iv) Prevention of Known hypersensitivity to fluconazole or to
NEONATE up to 2 weeks old, every 48 hours in Nausea, abdominal pain, diarrhoea, flatulence, Warfarin, oral sulfonylureas, phenytoin,
Fluconazole 2 mg/ml Injection Diflucan relapse of cryptococcal meningitis in AIDS patients Pregnancy, lactation, renal impairment related azole compounds. Co-administration of
NEONATE 2 - 4 weeks old) ii) 50 mg daily for 2 - 4 rash, headache rifampicin, cyclosporin, theophylline, cisapride
after completion of primary therapy v) Prevention of terfenadine
weeks, maximum 6 weeks iii) 400 mg initially then 200 -
fungal infections in immunocompromised patients
400 mg daily for 6 - 8 weeks. CHILD: 6-12 mg/kg daily
considered at risk as a consequence of HIV infections
(every 72 hours in NEONATE up to 2 weeks old, every
or neutropenia following cytotoxic chemotherapy,
48 hours in NEONATE 2 - 4 weeks old) iv) 100 - 200
radiotherapy or bone marrow transplant
mg daily v) 50 - 400 mg daily. CHILD: 3 - 12 mg/kg
daily (every 72 hours in NEONATE up to 2 weeks old,
every 48 hours in NEONATE 2 - 4 weeks old)
i) Oropharyngeal candidiasis: 50 - 100 mg daily for 7 -
14 days (Maximum 14 days) except in severely
immunocompromised patients, treatment can be
i) Oropharyngeal candidiasis, atrophic oral candidiasis continued for longer periods. Atrophic oral candidiasis
associated with dentures, other candidal infections of associated with dentures: 50 mg daily for 14 days.
mucosa ii) Tinea pedis, corporis, cruris, versicolor and Other candidal infections of mucosa: 50 - 100 mg daily
dermal candidiasis iii) Invasive candidal & cryptococcal for 14 - 30 days. CHILD: 3 - 6 mg/kg on first day then 3
infections (including meningitis) iv) Prevention of mg/kg daily (every 72 hours in NEONATE up to 2 Known hypersensitivity to fluconazole or to
Nausea, abdominal pain, diarrhoea, flatulence; Warfarin, oral sulfonylureas, phenytoin,
Fluconazole 50 mg Capsule Diflucan relapse of cryptococcal meningitis in AIDS patients weeks old, every 48 hours in NEONATE 2 - 4 weeks Pregnancy, lactation, renal impairment related azole compounds, co-administration of
rash, headache rifampicin, cyclosporin, theophylline, cisapride
after completion of primary therapy v) Prevention of old) ii) 50 mg daily for 2 - 4 weeks, maximum 6 weeks terfenadine
fungal infections in immunocompromised patients iii) 400 mg initially then 200 - 400 mg daily for 6 - 8
considered at risk as a consequence of HIV infections weeks. CHILD: 6 - 12 mg/kg daily (every 72 hours in
or neutropenia following cytotoxic chemotherapy, NEONATE up to 2 weeks old, every 48 hours in
radiotherapy or bone marrow transplant NEONATE 2 -4 weeks old) iv) 100 - 200 mg daily v) 50 -
400 mg daily. CHILD: 3 - 12 mg/kg daily (every 72
hours in NEONATE up to 2 weeks old, every 48 hours
in NEONATE 2 - 4 weeks old)
Leucopenia, thrombocytopenia, headache,
ADULT: 100 - 200 mg/kg daily in 4 divided doses by IV Renal impairment or failure and patients with existing drowsiness, confusion, hallucinations, nausea, Concurrent use with zidovudine may result in
Flucytosine 2.5 g/250 ml Injection Ancotil Treatment of systemic fungal infection Patients with a hypersensitivity to flucytosine
infusion over 20 - 40 minutes not more than 7 days bone marrow depression vomiting, diarrhoea, elevated liver function tests haematologic toxicity (neutropenia)
and cutaneous reactions
Leucopenia, thrombocytopenia, headache,
Renal impairment or failure and patients with existing drowsiness, confusion, hallucinations, nausea, Concurrent use with zidovudine may result in
Flucytosine 500 mg Tablet Ancotil Only for the treatment of fungal meningitis ADULT: 50 - 150 mg/kg/day in 4 divided doses Patients with a hypersensitivity to flucytosine
bone marrow depression vomiting, diarrhoea, elevated liver function tests haematologic toxicity (neutropenia)
and cutaneous reactions
Fever, chills, cough, dyspnoea, pneumonia,
gastrointestinal disturbances, stomatitis,
Routine monitoring of blood counts and haemoglobin
oedema, tumour lysis syndrome, skin rashes,
concentration. Monitor for signs of autoimmune Co-administration with pentostatin may lead to
B-cell chronic lymphocytic leukemia who have not 40 mg /m2 given daily for 5 consecutive days every 28 autoimmune haemolytic anaemia, haemorrhagic Renal impairment (creatinine clearance less 30
haemolytic anaemia, elderly. Avoid contact with skin pulmonary toxicity. Reduced metabolic activation
responded to or whose disease had progressed during days. Courses may be repeated every 28 days, usually cystitis, neurological disturbances including mL/min), decompensated haemolytic anaemia.
Fludarabine Phosphate 10 mg Tablet Fludara and eyes, avoid inhalation. Myelosuppression may of fludarabine with cytarabine. Reduced
or after treatment with at least one standard alkylating- for up to 6 cycles. Duration of treatment depends on peripheral neuropathy, agitation, confusion, Pregnancy and lactation. Concomitant use of live
be cumulative and severe increasing risk of therapeutic efficacy with dipyridamole and other
agent containing regimen treatment success and tolerability of the drug visual disturbances and coma. Progressive vaccines
opportunistic infections. Increased risk of tumour adenosine uptake inhibitors
encephalopathy and blindness, aplasia of skin,
lysis syndrome in patients with high tumour burden
myelosuppression, neurotoxicity, graft versus
host disease
Fever, chills, cough, dyspnoea, pneumonia,
gastrointestinal disturbances, stomatitis,
Routine monitoring of blood counts and haemoglobin
oedema, tumour lysis syndrome, skin rashes,
25 mg/m2 daily for 5 consecutive days every 28 days. concentration. Monitor for signs of autoimmune Co-administration with pentostatin may lead to
B-cell chronic lymphocytic leukaemia who have not autoimmune haemolytic anaemia, haemorrhagic Renal impairment (Creatinine clearance less
May be administered up to the achievement of a haemolytic anaemia, elderly. Avoid contact with skin pulmonary toxicity. Reduced metabolic activation
Fludarabine Phosphate 50 mg responded to or whose disease had progressed during cystitis, neurological disturbances including than 30 mL/min); decompensated haemolytic
Fludara maximal response (usually 6 cycles) and then the drug and eyes, avoid inhalation. Myelosuppression may of fludarabine with cytarabine. Reduced
Injection or after treatment with at least one standard alkylating- peripheral neuropathy, agitation, confusion, anaemia. Pregnancy and lactation. Concomitant
should be discontinued. Reduce dose by up to 50% in be cumulative and severe increasing risk of therapeutic efficacy with dipyridamole and other
agent containing regimen visual disturbances and coma. Progressive use of live vaccines
patients with mild to moderate renal impairment opportunistic infections. Increased risk of tumour adenosine uptake inhibitors
encephalopathy and blindness, aplasia of skin,
lysis syndrome in patients with high tumour burden
myelosuppression, neurotoxicity, graft versus
host disease
Spironolactone- result in a paradoxical dose-
As an adjunct to glucocorticoids in the management of Cirrhosis, diabetes mellitus, hypertension, Hypersensitivity to fludrocortisone, uncontrolled related increase in urinary potassium excretion.
Adrenocorticoid insufficiency (chronic): ADULT 1 tablet Fluid& electrolyte disturbances, muscle
primary adrenocortical insufficiency in Addison's hypothyroidism. Glaucoma can also occur with bacterial infection, viral or systemic fungal Loop diuretic- excessive potassium loss. Risk of
Fludrocortisone Acetate 0.1 mg Tablet Florinef daily. Salt-losing adrenogenital syndrome: ADULT 1 - 2 weakness, peptic ulcer, oedema, urticaria,
disease and treatment of salt-losing adrenogenital prolonged use. Discontinue treatment by reducing infections, psychotic tendencies, osteoporosis, tendon rupture may be increased in patients
tablets daily. CHILD and INFANT 0.5 - 1 tablet daily headache, glycosuria
syndrome the dosage gradually acute glomerulonephritis, chronic nephritis receiving concomitant fluoroquinolones and
corticosteroids
i) Initial, 0.2 mg IV over 30 seconds; if desired level of
consciousness not obtained after an additional 30
seconds, give dose of 0.3 mg IV over 30 seconds;
further doses of 0.5 mg IV over 30 seconds may be
given at 1-minutes intervals if needed to maximum total
dose of 3 mg; patients with only partial response to 3
mg may require additional slow titration to a total dose
of 5 mg; if no response 5 minutes after receiving total
dose of 5 mg, overdose is unlikely to be Hypersensitivity to flumazenil/benzodiazepines,
i) Diagnosis and/or management of benzodiazepine Patients with a history of long-term benzodiazepine Cardiac arrhythmias, bradycardia, dizziness,
benzodiazepine and further treatment with flumazenil cyclic antidepressant overdose, patients who
overdose due to self-poisoning or accidental overdose abuse, head injuries, history of panic disorder, liver nausea, vomiting, seizure, injection site pain, Thiopental : decreased duration of thiopental
Flumazenil 0.5 mg/5 ml Injection Anexate will not help ii) 0.2 mg IV over 15 seconds; if desired have been given a benzodiazepine for control of
ii) Reversal of sedation following anaesthesia with disease, drug and alcohol dependent patients, headache, abnormal vision, blurred vision, anaesthetic effects
level of consciousness is not obtained after waiting 45 a potentially life-threatening condition (eg, control
benzodiazepine neuromuscular blocking agents agitation
seconds, a second dose of 0.2 mg IV may be given and of intracranial pressure or status epilepticus)
repeated at 60-seconds intervals as needed (up to a
maximum of 4 additional times) to a maximum total
dose of 1 mg; most patients respond to doses of 0.6 to
1 mg; in the event of resedation, repeated doses may
be given at 20-minutes intervals if needed; for repeat
treatment, no more than 1 mg (given as 0.5 mg/minute)
should be given at any one time and no more than 3 mg
should be given in any one hour
Excessive sedation can occur with alcohol,
i) ADULT: 5 - 10 mg daily preferably at night. ELDERLY Drowsiness, fatigue, asthenia, depression, Hypersensitivity to flunarizine or cinnarizine,
i) Migraine prophylaxis ii) Maintenance treatment of Hepatic insufficiency, elderly, depression, hypnotics or tranquilizers. Amiodarone, beta
more than 65 years: 5 mg at night. Maintenance 5-day headache, porphyria, dizziness, insomnia, history of depressive illness, pre-existing
Flunarizine HCl 5 mg Capsule Sibelium vestibular disturbances and of cerebral and peripheral pregnancy, breast feeding, may impair ability to drive blockers, carbamazepine, NSAIDs,
treatment at the same daily dose ii) 5 - 10 mg at night. If tremor, extrapyramidal effects, nausea, vomiting, symptoms of Parkinson's disease or other
disorders or operating machinery anticoagulants, rifampin, sumatriptan, alcohol,
no improvement after 1 month, discontinue treatment dry mouth, gastric pain, weight gain extrapyramidal disorders
hypnotics or tranquilisers, diclofenac, ibuprofen
Nausea and headache, other symptoms and
Moisten tip with tear fluid from lower fornix, sterile water
Diagnostic fluorescein angiography or angioscopy of History of allergy or bronchial asthma. Pregnancy signs of hypersensitivity, allergic conjunctivitis, Hypersensitivity to any of the components of
Fluorescein 1 mg Ophthalmic Strip Fluorets or ophthalmic solution and gently stroke across the Not known
the fundus and of the iris vasculature especially in the first trimester, lactation peri-orbital oedema, anaphylactic reaction, product. Not to be used with soft contact lenses
conjunctiva
urticaria, rash
Nausea and headache, gastrointestinal distress,
syncope, vomiting, hypotension, other symptoms
Fluorescein Sodium 10% in 5 ml Diagnostic fluorescein angiography or angioscopy of History of allergy or bronchial asthma. Pregnancy Hypersensitivity to any of the components of
Fluorescite 500 mg IV and signs of hypersensitivity, cardiac arrest, Not known
Injection the fundus and of the iris vasculature especially in the first trimester, lactation product
basilar artery ischaemia, severe shock,
convulsions and thrombophlebitis at injection site
Burning or stinging, ocular irritation, unpleasant Hypersensitivity to its component, ocular viral or
Fluorometholone 0.1% Ophthalmic FML liquifilm, Flarex
Treatment of steroid responsive ocular inflammation 1-2 drops 2 - 4 times dailyy Glaucoma, corneal or scleral thinning taste, blurred vision, increased intra-ocular fungal or tuberculosis infection, contact lense Not known
Suspension ophth Susp
pressure, glaucoma, cataract, corneal thinning use
500 - 600 mg/m2 IV in combination with other cytotoxic
Caution in ischaemic heart disease, renal or hepatic
agents, repeated every 3 weeks or 300 - 450 mg/m2 IV Myelosuppression, mucositis, pigmentation of
dysfunction, elderly. Previous pelvic irradiation,
Cancers of gastro-intestinal tract, breast and pancreas, slow bolus daily for 5 days in combination with infused vein, somnolence, confusion, ataxia, fits,
previous treatment with alkylating agents. Hypersensitivity to fluorouracil, pregnancy,
Fluorouracil 1 g/20 ml Injection head and neck. Ophtalmological indication: biological response modifiers, repeated every 4 weeks encephalopathy, changes in ECG, chest pain, Leucovorin, warfarin, methotrexate, thymidine
Discontinue upon development of unexpected grade lactation
trabeculectomy or 3000 - 3750 mg/m2 as a continuous infusion over 5 nausea and vomiting, diarrhoea, photosensitivity,
3 or 4 stomatitis, oesophagopharyngitis, diarrhoea,
days in combination with a platinum compound every 3 hand foot syndrome
myelosuppression or neurologic toxicities
to 4 weeks
Myelosuppression, mucositis, pigmentation of
infused vein, somnolence, confusion, ataxia, fits,
Fluorouracil 100 mg Tablet 5-FU Colorectal cancer 200 - 300 mg daily in 1 - 3 divided doses encephalopathy, changes in ECG, chest pain, Leucovorin, warfarin, methotrexate, thymidine
nausea and vomiting, diarrhoea, photosensitivity,
hand foot syndrome
500 - 600 mg/m2 IV in combination with other cytotoxic
agents, repeated every 3 weeks or 300 - 450 mg/m2 IV Myelosuppression, mucositis, pigmentation of
Cancers of gastro-intestinal tract, breast and pancreas, slow bolus daily for 5 days in combination with infused vein, somnolence, confusion, ataxia, fits,
Fluorouracil 250 mg/5 ml Injection 5-FU head and neck. Ophtalmological indication: biological response modifiers, repeated every 4 weeks encephalopathy, changes in ECG, chest pain, Leucovorin, warfarin, methotrexate, thymidine
trabeculectomy or 3000 - 3750 mg/m2 as a continuous infusion over 5 nausea and vomiting, diarrhoea, photosensitivity,
days in combination with a platinum compound every 3 hand foot syndrome
to 4 weeks
i) 20 mg once daily increased after 3 weeks if
necessary, usual dose 20 - 60 mg (ELDERLY 20 - 40
Tremor, asthenia, gastrointestinal disorder,
mg) once daily max 80 mg once daily (ELDERLY max History of seizure, elderly, volume depletion, Drugs metabolised by cytochrome P450, CNS
inappropriate secretion of adrenocortical
60 mg once daily). ii) Initially 20 mg once daily diabetes, pregnancy and breastfeeding, impaired active drugs, drugs highly bound to protein
hormone, nervousness, insomnia, headache, Present or recent treatment with MAOIs,
Fluoxetine HCl 20 mg Capsule Prozac i) Depressive illness ii) Obsessive-compulsive disorder increased after 2 weeks if necessary, usual dose 20 - renal/liver function, abnormal bleeding, anxiety and plasma. Benzodiazepines, caffeine, ergotamine,
anorexia, anxiety, dry mouth, decreased libido, hypersensitivity to fluoxetine
60 mg (ELDERLY 20 - 40 mg) once daily, max 80 mg insomnia, hyponatremia, rash, avoid abrupt clozapine, lithium, MAOIs, phenytoin,
delayed ejaculation, anorgasmia, sweating and
(ELDERLY max 60 mg) once daily, discontinue if no withdrawal antipsychotics, propranolol, warfarin.
serotonin syndrome
improvement within 10 weeks. CHILD and
ADOLESCENT under 18 years are not recommended
Patients known to have a predisposition to

movement disorders (may cause extrapyramidal
By deep IM, initial test dose of 5-20 mg, then after at Sedation, restlesness, extrapyramidal
symptoms). Hepatic or renal impairment. CV or
least 7 days. 20 - 40 mg repeated at intervals of 2 - 4 symptoms, anticholinergic effects, weight gain. Hypersensitivity to flupenthixol. Extremely Barbiturates, guanethidine or similar compounds,
respiratory disease, phaeochromocytoma.
Flupenthixol Decanoate Depot 20 weeks. Maximum 400 mg weekly. Usual maintenance Insomnia, drowsiness. Rarely extrapyramidal excitable or overactive patients. Acute alcohol, metoclopramide and piperazine, tramadol. May
Fluanxol Chronic psychoses Convulsive disorders. Withdraw gradually if patient
mg/ml lnjection dose 50 mg every 4 weeks to 300 mg every 2 weeks. symptoms, if recommended dose is exceeded. barbiturate or opiate poisoning. Bone marrow enhance the response to alcohol, and other CNS
was previously treated with neuroleptics with
ELDERLY, initially quarter to half adult dose. CHILD not Occasionally tardive dyskinesia in long-term depression, coma depressants
sedative effect. Patients on high doses and long-
recommended. Deep IM recommended. Not for IV use therapy
term therapy should be monitored carefully. Should
not be given during pregnancy and lactation
Tramadol, increased risk of seizures. Cisapride,

levofloxacin, increased risk of cardiotoxicity (QT
Patients exposed to extreme heat or phosphorous
prolongation, torsades de pointes, cardiac
insecticides, history of convulsive disorder, mitral Weight gain, agranulocytosis, akathisia,
arrest). Pethidine, increase in central nervous
insufficiency or other cardiovascular diseases and extrapyramidal effects, hepatotoxicity,
system and respiratory depression. Levodopa,
phaeochromocytoma; history of neuroleptic neuroleptic malignant syndrome,
loss of levodopa efficacy. Procyclidine,
malignant syndrome, history of cholestatic jaundice, hyperprolactinaemia, sedation, orthostatic Comatose or severely depressed patients, blood
By deep IM : Test dose 12.5 mg (6.25 mg in decreased phenothiazine serum concentrations,
hypersensitivity reaction to other phenothiazines, hypotension, anticholinergic effects, seizures, dyscrasias, liver damage, hypersensitivity to
Fluphenazine Decanoate 25 mg/ml ELDERLY), then after 4-7 days 12.5 mg-100 mg decreased phenothiazines effectiveness,
Modecate Long term management of psychotic disorders patients undergoing surgery may require lower aplastic anaemia, cholestatic jaundice, fluphenazine products, subcortical brain
Injection repeated at intervals of 14-35 days, adjusted according enhance anticholinergic effects (ileus,
doses of anaesthetics or depressants, history of drowsiness, dependence, antimuscarinic effects, damage, phaeochromocytoma, severe
to response. CHILD not recommended hyperpyrexia, sedation, dry mouth). Sertraline,
dermatoses, myasthenia gravis, Parkinson's insomnia, depression, convulsions, agitation, hypotension, bone marrow depression
fluoxetine; increased risk of developing acute
disease, seizure disorder, elderly, debilitated, liver or tachycardia, postural hypotension, allergic
parkinsonism. Class Ia and III antiarrhytmics,
kidney impairment, CV or respiratory disorders, reactions, agranulocytosis, tardive dyskinesia,
beta2 agonists, carbamazepine, central alpha2
diabetes, pheochromocytoma, epilepsy, glaucoma. depressive reactions
agonists, systemic corticosteroids, diuretics,
May impair temperature regulatory mechanism
lithium tricyclic antidepressants, alcohol, CNS
depressants, clonidine
Diarrhoea, cystitis, hot flushes, hepatotoxicity,
drowsiness, confusion, depression, anxiety,
Hypersensitivity to flutamide, severe hepatic
Flutamide 250 mg Tablet Fugerel Metastatic prostatic carcinoma 250 mg 3 times daily Monitor liver function, aniline toxicity, use in women decreased libido, impotence, gynaecomastia, Warfarin
impairment, pregnancy
discolouration of urine, hypertension, myocardial
infarction, peripheral edema
ADULT and CHILD more than 12 years i) Mild asthma :
Not for acute attacks but for routine long-term
100 mcg - 250 mcg twice daily ii) Moderate asthma :
management. Caution when transfering patients Mouth and throat candidiasis, hoarseness
250 - 500 mcg twice daily iii) Severe asthma : 500 mcg -
from systemic steroid treatment, pregnancy, rarely, (patients are advised to gargle after using the
1000 mcg twice daily. Alternatively, the starting dose of
Fluticasone Propionate 125 mcg/dose inhaled therapy may mask underlying eosinophilic medication), paradoxical bronchospasm, Caution when co-administered with potent
Flixotide Prophylactic treatment for asthma fluticasone dipropionate may be gauged at half the total Hypersensitivity to any of the components
Inhalation conditions e.g. Churg Strauss Syndrome, active or cutaneous hypersensitivity reactions. Headache, CYP3A4 inhibitors e.g. ketoconazole, ritonavir
daily dose of beclomethasone dipropionate or
quiescent pulmonary tuberculosis. Safety and giddiness, dizziness,sleep disorders, migraines,
equivalent administered by inhalation. CHILD 4 - 11
efficacy not established for children younger than 12 paralysis of cranial nerves, mood disorders
years, 50 mcg twice daily (maximum 100 mcg twice
years
daily)
Blurred vision, dry mouth, tremor, gastrointestinal
disturbances, somnolence, constipation, Warfarin, phenytoin, theophyline, propanolol,
Concomitant use with MAOIs, hepatic insufficiency, headache, insomnia, vomiting, dizziness, lithium, benzodiazepines, caffeine, ergotamine,
For depression, initially 50 - 100 mg daily in the Use of MAOI within 14 days, coadministration of
children, epilepticus, pregnancy, lactation, agitation, extrapyramidal effects, bradycardia, MAOIs, sildenafil, statins, heparin, NSAIDs,
evening, increased if necessary to 300 mg daily (over terfenadine, astemizole or cisapride, may cause
cardiovascular disease, avoid abrupt withdrawal, seizures, hepatotoxicity, withdrawal syndrome, aspirin, carbamazepin, clozapin, haloperidol,
Fluvoxamine 100 mg Tablet Luvox Depressive disorder 150 mg in divided doses); usual maintenance dose 100 increased plasma concentrations of these drugs
elderly, abnormal bleeding, hyponatremia, may Steven Johnson Syndrome, anphylactic reaction, proton pump inhibitor, tricyclic antidepressants,
mg daily. CHILD and ADOLESCENT under 18 years and an increased incidence of side effects,
activate mania or hypomania, history of seizure, abnormal ejaculation, hepatitis, asthenia, grapefruit, St. John wort, dilatiazem,
not recommended hypersensitivity to fluvoxamine
suicidal ideation, worsening depression abnormal bleeding, hyponatremia, seizure, metoclopramide, serotonergic drugs, linezolid,
serotonin syndrome, worsening depression, tramadol, celecoxib
hypomania, mania (rare), suicidal thoughts
Blurred vision, dry mouth, tremor, gastrointestinal
disturbances, somnolence, constipation, Warfarin, phenytoin, theophyline, propanolol,
Concomitant use with MAOIs, hepatic insufficiency, headache, insomnia, vomiting, dizziness, lithium, benzodiazepines, caffeine, ergotamine,
For depression, initially 50 - 100 mg daily in the Use of MAOI within 14 days, coadministration of
children, epilepticus, pregnancy, lactation, agitation, extrapyramidal effects, bradycardia, MAOIs, sildenafil, statins, heparin, NSAIDs,
evening, increased if necessary to 300 mg daily (over terfenadine, astemizole or cisapride, may cause
cardiovascular disease, avoid abrupt withdrawal, seizures, hepatotoxicity, withdrawal syndrome, aspirin, carbamazepin, clozapin, haloperidol,
Fluvoxamine 50 mg Tablet Luvox Depressive disorder 150 mg in divided doses); usual maintenance dose 100 increased plasma concentrations of these drugs
elderly, abnormal bleeding, hyponatremia, may Steven Johnson Syndrome, anphylactic reaction, proton pump inhibitor, tricyclic antidepressants,
mg daily. CHILD and ADOLESCENT under 18 years and an increased incidence of side effects,
activate mania or hypomania, history of seizure, abnormal ejaculation, hepatitis, asthenia, grapefruit, St. John wort, dilatiazem,
not recommended hypersensitivity to fluvoxamine
suicidal ideation, worsening depression abnormal bleeding, hyponatremia, seizure, metoclopramide, serotonergic drugs, linezolid,
serotonin syndrome, worsening depression, tramadol, celecoxib
hypomania, mania (rare), suicidal thoughts
i) ADULT initially 5 mg daily for 4 months or until
Antiepileptics, oral contraceptives,
haematopoietic response obtained. Maintenance: 5 mg Folic acid should never be given alone or in
i) For the prevention and treatment of folate deficiency aminosalicylates, barbiturates, antituberculous
every 1 - 7 days depending on underlying disease conjunction with inadequate amounts of vitamin B 12
Folic Acid 5 mg Tablet - states ii) For the prevention of neural tube defect in the Gastrointestinal disturbances, urticaria, pruritus Pernicious, aplastic or normocytic anaemias drugs, alcohol and folic acid antagonists such as
CHILD up to 1 year, 500 mcg/kg daily; over 1 year, as for the treatment of undiagnosed megaloblastic
foetus aminopterin, methotrexate, trimethoprim and
adult dose ii) 5 mg daily starting before pregnancy and anaemia (masking of true deficiency state)
sulphonamides
continued through the first trimester
i) Infertility treatment in anovulatory women who have Pregnancy, lactation, ovarian enlargement or Other ovulation stimulation agents may
i) 75 - 150 IU daily, should commence within the first 7
been unresponsive to treatment with clomiphene citrate Fever, arthralgia, pain in lower abdominal region, cyst not due to polycystic ovarian disease, potentiate the follicular response whereas
days of the menstrual cycle and increased by 37.5 IU or Evaluate patient for hypothyroidism, adrenocortical
Follitropin Alpha (Recombinant ii) Stimulation of follicular development for intra-uterine nausea, vomiting and weight gain, ovarian gynaecological haemorrhages of unknown concurrent use in GnRH agonist- induced
Gonal F 75 IU at 7 or 14 days interval. Max daily dose 225 IU ii) deficiency, hyperprolactinaemia and pituitary or
Human FSH) 300 IU Injection cycles iii) Stimulation of follicular development in hyperstimulation syndrome (OHSS), multiple aetiology, ovarian, uterine or mammary pituitary desensitization may increase the
150 - 225 IU daily commencing on days 2 or 3 of the hypothalamic tumours before starting therapy
assisted reproductive technology in the management of pregnancy carcinoma tumours of the hypothalamus and dosage of Gonal-F needed to elicit an adequate
cycle. Max daily dose 450 IU
infertility pituitary gland ovarian response
i) Infertility treatment in anovulatory women who have Pregnancy, lactation, ovarian enlargement or Other ovulation stimulation agents may
i) 75 - 150 IU daily, should commence within the first 7
been unresponsive to treatment with clomiphene citrate Fever, arthralgia, pain in lower abdominal region, cyst not due to polycystic ovarian disease, potentiate the follicular response whereas
days of the menstrual cycle and increased by 37.5 IU or Evaluate patient for hypothyroidism, adrenocortical
Follitropin Alpha (Recombinant ii) Stimulation of follicular development for intra-uterine nausea, vomiting and weight gain, ovarian gynaecological haemorrhages of unknown concurrent use in GnRH agonist- induced
Gonal F 75 IU at 7 or 14 days interval. Max daily dose 225 IU ii) deficiency, hyperprolactinaemia and pituitary or
Human FSH) 75 IU Injection cycles iii) Stimulation of follicular development in hyperstimulation syndrome (OHSS), multiple aetiology, ovarian, uterine or mammary pituitary desensitization may increase the
150 - 225 IU daily commencing on days 2 or 3 of the hypothalamic tumours before starting therapy
assisted reproductive technology in the management of pregnancy carcinoma tumours of the hypothalamus and dosage of Gonal-F needed to elicit an adequate
cycle. Max daily dose 450 IU
infertility pituitary gland ovarian response
Infertility treatment in anovulatory women who have Pregnancy, lactation, ovarian enlargement or
been unresponsive to treatment with clomiphene To be individualized. Give in multiples of 50 IU. Starting cyst not due to polycystic ovarian disease, Concomitant use with clomiphene citrate may
Ovarian hyperstimulation, bruising, pain,
Follitropin Beta (Recombinant Human citrate. Stimulation of follicular development for intra- dose can be 50 IU - 200 IU daily. It can be a step-up Presence of uncontrolled non-gonadal gynaecological haemorrhages of unknown enhance the follicular response. A higher dose
Puregon redness, swelling and itching, ectopic pregnancy,
FSH) 300 IU Injection uterine insemination cycles. Stimulation of follicular regime or a step-down, depending on the protocol and endocrinopathies should be excluded aetiology, ovarian, uterine or mammary may be needed after pituitary desensitization
multiple gestations, arteriothromboembolism
development in asssisted reproductive technology in the ovarian response carcinoma, tumours of the hypothalamus and induced by a GnRH agonist
the management of infertility pituitary gland
Infertility treatment in anovulatory women who have Pregnancy, lactation, ovarian enlargement or
been unresponsive to treatment with clomiphene To be individualized. Give in multiples of 50 IU. Starting cyst not due to polycystic ovarian disease, Concomitant use with clomiphene citrate may
Ovarian hyperstimulation, bruising, pain,
Follitropin Beta (Recombinant Human citrate. Stimulation of follicular development for intra- dose can be 50 IU - 200 IU daily. It can be a step-up Presence of uncontrolled non-gonadal gynaecological haemorrhages of unknown enhance the follicular response. A higher dose
Puregon redness, swelling & itching, ectopic pregnancy,
FSH) 50 IU Injection uterine insemination cycles. Stimulation of follicular regime or a step-down, depending on the protocol and endocrinopathies should be excluded aetiology, ovarian, uterine or mammary may be needed after pituitary desensitization
multiple gestations, arteriothromboembolism
development in assisted reproductive technology in the the ovarian response carcinoma, tumours of the hypothalamus and induced by a GnRH agonist
management of infertility pituitary gland
i) 2.5 mg once daily given by SC, administered 6 hr
following surgical closure provided homeostasis has
been established. Usual duration of therapy is 5 to 9
days; for hip fracture patients, an extended course of
up to 24 days is recommended. ii) ADULT more than 18
years: 2.5 mg once daily given by SC, initiated as soon
as possible after diagnosis and continued for up to 8
i) Prevention of venous thromboembolic events (VTE) days or until hospital discharge. If patient needs to
Increased haemorrhagic risk eg congenital or Active major bleeding; increased risk for major
in orthopedic surgery (e.g. hip fracture, major knee or undergo PCI, unfractionated heparin to be admin as per
acquired coagulopathy, active ulcerative GI disease, bleeding episodes;risk of uncontrollable
hip replacement surgery), abdominal surgery in local practice protocol, taking into account the patient's
recent intracranial haemorrhage or shortly after hemorrhage, bacterial endocarditis, body weight
patients at risk of thromboembolic complication. ii) bleeding risk and time of last dose of fondaparinux.
brain, spinal or ophth surgery, diabetic retinopathy, less than 50 kg for prophylactic therapy of hip Agents that increase the risk of hemorrhage (eg,
Treatment of unstable angina or non-ST segment Fondaparinux may be restarted no earlier than 2 hr Pruritus, rash, injection site hemorrhage, fever,
Fondaparinux Sodium 2.5 mg/0.5 ml uncontrolled arterial hypertension, moderate renal fracture, hip replacement or knee replacement other anticoagulants, NSAIDs, platelet inhibitors).
Arixtra elevation myocardial infarction [UA/NSTEMI] in patients after sheath removal. iii) ADULT more than 18 years: anemia, bleeding, thrombocytopenia, fever,
Injection impairment (CrCl < 30-50 mL/min), severe hepatic surgery, or abdominal surgery; increased risk for Discontinue prior to administration of
for whom urgent invasive management (PCI) is not 2.5 mg once daily; first dose to be given IV (directly nausea, vomiting, constipation
impairment. Measure platelet counts at baseline & major bleeding episode. Fondaparinux-related fondaparinux
indicated. iii) Treatment of ST segment elevation through an existing IV line or as infusion in 25 or 50 ml
end of treatment. Elderly. Pregnancy & lactation. thrombocytoenia. Hypersensitivity to
myocardial infarction (STEMI) in patients managed with of 0.9% saline over 1-2 min), subsequent doses to be
Avoid concurrent administration with drugs that may fondaparinux. Severe renal impairment (CrCl
thrombolytics or are not receiving other forms of given SC. Treatment to be initiated as soon as
increase haemorrhagic risk less than 30 ml/min)
reperfusion therapy diagnosis is made and continued up to a max of 8 days
or until hospital discharge, whichever comes earlier. If
patient needs to undergo non-primary PCI,
unfractionated heparin to be admin as per local practice
protocol, taking into account the patient's bleeding risk
and time of last dose of fondaparinux. Fondaparinux
may be restarted no earlier than 3 hr after sheath
removal
Thyrotoxicosis, severe cardivascular disorder e.g.
ischaemic heart disease, tachyarrhythmias or severe
heart failure, coronary insufficiency, cardiac
i) ADULT and ELDERLY : 6 - 12 mcg (1 - 2 puff) once - arrhythmias, and hypertension, acute severe
twice daily, maximum daily dose 8 puff. CHILD over 6 asthma, severe liver cirrhosis, increased risk of
Formoterol Fumarate Dihydrate 4.5 i) Moderate persistent and severe persistent asthma ii) Hypersensitivity to formoterol or to inhaled MAOIs : increased risk of tachycardia, agitation
Oxis years : 2 puff once - twice daily ii) ADULT and asthma-related death and serious asthma events, Headache, palpitations, tremor
mcg /dose Inhalation COPD lactose. Pregnancy and lactation or hypomania
ELDERLY : 2 puff once - twice daily, maximum 4 puff bronchospasm, potentially fatal paradoxical,
once or twice daily concomitant corticosteroid use - discontinuing or
reducing corticosteroids may precipitate a worsening
of asthma symptoms, diabetes mellitus or
ketoacidosis
Thyrotoxicosis, severe cardivascular disorder e.g.
ischaemic heart disease, tachyarrhythmias or severe
heart failure, coronary insufficiency, cardiac
i) ADULT and ELDERLY : 1 puff once - twice daily, arrhythmias, and hypertension, acute severe
maximum daily dose 4 - 6 puff. CHILD over 6 years : 1 asthma, severe liver cirrhosis, increased risk of
Formoterol Fumarate Dihydrate 9 i) Moderate persistent and severe persistent asthma ii) Hypersensitivity to formoterol or to inhaled MAOIs : increased risk of tachycardia, agitation
Oxis puff once - twice daily, maximum dose : 2 puff daily ii) asthma-related death and serious asthma events, Headache, palpitations, tremor
mcg/dose Inhalation COPD lactose. Pregnancy and lactation or hypomania
ADULT and ELDERLY : 1 puff, once - twice daily, bronchospasm, potentially fatal paradoxical,
maximum dose : 2 - 4 puff daily concomitant corticosteroid use - discontinuing or
reducing corticosteroids may precipitate a worsening
of asthma symptoms, diabetes mellitus or
ketoacidosis
Framycetin Sulphate 0.5%, Herpes simplex infection, viral diseases of
Can increase nephrotocixity with amphotericin,
Dexamethasone 0.05% and Sofradex Otitis externa Apply 2 - 3 drops 3 to 4 times daily Glaucoma, pregnancy, prolonged use in infants Sensitivity reactions cornea and conjuctiva, tuberculosis and fungal
cyclosporin
Gramicidin 0.005% Ear Drops diseases of eyes, herpetic keratitis
Irritation of the skin, inflammation, blistering,
200 - 500 ml of Fuller's Earth together with magnesium
Fuller's Earth 30% Suspension Fuller's Earth Adsorbent in pesticide poisoning Not known cracking, shedding of the nails, delayed healing Not known Not known
sulphate or mannitol every 2 hours for several days
of cuts and wounds
Alterations in blood glucose and glucose tolerance
tests. Diabetes mellitus, electrolyte imbalance (eg:
hypokalaemia, hyponatraemia), fluid imbalance,
dehydration, blood volume reduction with circulatory
collapse and possible vascular thrombosis and
emboli may occur with excessive diuresis, especially
Anuria, hypersensitivity to furosemide, hepatic Activated charcoal, amikacin, gentamicin,
in elderly patients. Gout or hyperuricaemia. Hepatic
Initially 20 -40 mg IM or slow IV (rate not exceeding 4 Hypokalaemia, hyperuricaemia, hypotension, coma and pre-coma. Severe hypokalaemia, kanamycin, angiotensin converting enzyme
Furosemide 20 mg/2 ml Injection Lasix Pulmonary oedema disease (cirrhosis and ascites). Hypersensitivity to
mg/min). CHILD: 0.5 - 1.5 mg/kg. Max: 20 mg daily hyperglycaemia severe hyponatraemia, hypovolaemia with or inhibitors, aspirin, chloral hydrate, digoxin
sulfonamides. Ototoxicity (hearing loss, tinnitus),
without concomitant hypotension steroids, NSAIDs
avoid rapid injection, high doses or concurrent
administration of other ototoxic agents. If high-dose
therapy is used, controlled intravenous infusion is
recommended at a rate not to exceed 4 mg/min.
Severe progressive renal disease (azotemia,
oliguria). Systemic lupus erythematosus
Alterations in blood glucose and glucose tolerance

tests. Diabetes mellitus, electrolyte imbalance (eg,
hypokalaemia, hyponatraemia), fluid imbalance,
ADULT: Initial 40 - 80 mg on morning if required, can be dehydration, blood volume reduction with circulatory Anuria, hypersensitivity to furosemide, hepatic Activated charcoal, amikacin, gentamicin,
increased to a max of 1 g/day in certain cases collapse and possible vascular thrombosis and Hypokalaemia, hyperuricaemia, hypotension, coma and pre-coma. Severe hypokalaemia, kanamycin, angiotensin converting enzyme
Furosemide 40 mg Tablet Lasix Pulmonary oedema
especially in chronic renal failure. CHILD : 1 - 3 mg/kg emboli may occur with excessive diuresis especially hyperglycaemia severe hyponatraemia, hypovolaemia with or inhibitors, aspirin, chloral hydrate, digoxin
daily in elderly patients. Gout or hyperuricaemia. Hepatic without concomitant hypotension steroids, NSAIDs
disease (cirrhosis and ascites). Hypersensitivity to
sulfonamides. Ototoxicity (hearing loss, tinnitus),
systemic lupus erythematosus
ADULT : 1 oral or 1 nasal inhalation 4 hourly, withdraw
Local antibiotic, anti-inflammatory treatment of Systematically report any other ongoing
if no improvement after 7 days. CHILD : 1 oral or 1 Treatment should be less than 10 days, reevaluate Rare cases of buccopharyngeal irritation and Hypersensitivity to fusafungine. Children less
Fusafungine 1% Nasal Spray Locabiotal infectious and inflammatory syndromes of the treatment to the doctor or pharmacist so as to
nasal inhalation 6 hourly, withdraw if no improvement after this sneezing than 30 months of age (risk of laryngospasm)
respiratory mucosa avoid any interaction between several drugs
after 7 days
Treatment of infections caused by susceptible Hepatotoxicity and increased plasma
organisms especially Staphylococcal infections ADULT: 500 mg 3 times daily, skin and soft tissue Gastrointestinal disturbances (dyspepsia, concentrations of fusidic acid and ritonavir. An
Fusidate, Sodium 250 mg Tablet Fucidin Hepatic insufficiency. Pregnancy and lactation Hypersensitivity to fusidic acid and or its salts
including Methicillin Resistant Staphylococcus aureus infection: 250 - 500 mg twice daily nausea, vomiting) increased risk of myopathy or rhabdomyolysis
(MRSA) with simvastatin
1 drop in conjunctival sac 12 hourly. To be continued
for 2 days after the eye appears normal. On the first
Cross allergy between fusidic acid and other
Fusidic Acid 1% Eye Drops Fucithalmic For staphylococcal infections day of treatment, may be applied more frequently : 1 Do not apply to eyes with contact lenses Transient stinging Allergy to any of the constituents
antibiotics has not been reported
drop 4 hourly. Surgical prophylaxis : 1 drop every 12
hours, 24 - 48 hours before operation
Skin infections caused by staphylococci, streptococci,
Avoid contact with eyes and other mucous Infections caused by non-susceptible organisms
Fusidic Acid 2% Cream Fucidin corynebacterium minutissumun and other sodium Apply to affected area 2 - 3 times daily Rashes, irritation, pruritus and contact dermatitis Not known
membranes in particular Pseudomonas aeruginosa
fusidate-sensitive organisms
Inflammatory dermatosis where bacterial infection is
likely to occur eg atopic eczema, discoid eczema,
Fusidic Acid 2% in Betamethasone Uncovered lesion- Apply 2 to 3 times daily. Covered Avoid prolong use on flexures and intertriginous Viral disease of skin, perioral dermatitis, acne
Fucicort stasis eczema, seborrhoic dermatitis, contact Mild stinging, irritation, rash Not known
Valerate 0.1% Cream lesions- Less frequent applications may be adequate areas should be avoided rosacea and ulcerative condition
dermatitis, lichen simplex chronicus, psoriasis, discoid
lupus erythematosus
Hepatotoxicity and increased plasma
Treatment of infections caused by staphylococcal ADULT : 15 ml 3 times daily. CHILD 1 - 5 years: 5 ml 3
Gastrointestinal disturbances (dyspepsia, concentrations of fusidic acid and ritonavir. An
Fusidic Acid 50 mg/ml Suspension Fucidin especially Methicillin Resistant Staphylococcus aureus times daily; 5 - 12 years: 10 ml 3 times daily. INFANT : Hepatic insufficiency. Pregnancy and lactation Hypersensitivity to fusidic acid and or its salts
nausea, vomiting) increased risk of myopathy or rhabdomyolysis
(MRSA) 1 ml/kg body weight daily in 3 - 4 divided doses
with simvastatin
ADULT : 500 mg 3 times daily diluted to 250 - 500 ml Hepatotoxicity and increased plasma
Treatment of severe staphylococcal infections
infused slowly over 2 hours. Maximum : 2 g daily. concentrations of fusidic acid and ritonavir. An
Fusidic Acid 500 mg Injection Fucidin especially Methicillin Resistant Staphylococcus aureus Hepatic insufficiency, pregnancy and lactation Reversible jaundice, thrombophlebitis Hypersensitivity to fusidic acid and or its salts
CHILD and INFANT : 20 mg/kg/day divided into 3 equal increased risk of myopathy or rhabdomyolysis
(MRSA). To be used in combination therapy only
doses infused slowly over 2 - 4 hours with simvastatin
Renal insufficiency, patients less than 12 years old,
i) ADULT: 900 - 1800 mg/day in 3 divided doses. diabetes, pregnancy, lactation, elderly, renal
i) Add-on therapy for intractable partial epilepsy,
CHILD: 10-40 mg/kg/day in 3 divided doses ii) ADULT: impairment, haemodialysis, absence seizures. Avoid
refractory to standard anti-epileptic drugs ii) Treatment Somnolence, dizziness, ataxia, weight gain,
900 mg/day in 3 equally divided doses, maximum: 3600 abrupt withdrawal. Discontinuation of gabapentin
of various types of neuropathic pain, both peripheral fatigue, nystagmus, tremor, diplopia, amnesia, Antacid like Maalox reduced the bioavailability of
Gabapentin 100 mg Tablet Neurontin mg/day. Initiate therapy with 300 mg once on Day 1, and or addition or substitution of alternative therapy Hypersensitivity to gabapentin
(which includes diabetic neuropathy, post-herpetic dyspepsia, asthenia, leukopenia, headache, gabapentin
300 mg twice daily on Day 2, 300 mg three times daily should be gradual, over a minimum of 1 week. May
neuralgia, trigeminal neuralgia) in adult more than 18 myalgia
on Day 3. Thereafter, the dose may be increased in 3 affect ability to drive or operate machinery. Potential
years
equally divided doses up to maximum 3600 mg/day for an increase in risk of suicidal thoughts or
behaviours
i) Add-on therapy for intractable partial epilepsy,
CHILD: 10-40 mg/kg/day in 3 divided doses ii) ADULT: impairment, haemodialysis, absence seizures. Avoid
refractory to standard anti-epileptic drugs ii) Treatment Somnolence, dizziness, ataxia, weight gain,
900 mg/day in 3 equally divided doses, maximum: 3600 abrupt withdrawal. Discontinuation of gabapentin
of various types of neuropathic pain, both peripheral fatigue, nystagmus, tremor, diplopia, amnesia, Antacid like Maalox reduced the bioavailability of
Gabapentin 300 mg Capsule Neurontin mg/day. Initiate therapy with 300 mg once on Day 1, and or addition or substitution of alternative therapy Hypersensitivity to gabapentin
(which includes diabetic neuropathy, post-herpetic dyspepsia, asthenia, leukopenia, headache, gabapentin
300 mg twice daily on Day 2, 300 mg three times daily should be gradual, over a minimum of 1 week. May
neuralgia, trigeminal neuralgia) in adult more than 18 myalgia
on Day 3. Thereafter, the dose may be increased in 3 affect ability to drive or operate machinery. Potential
years
equally divided doses up to maximum 3600 mg/day for an increase in risk of suicidal thoughts or
behaviours
i) Add-on therapy for intractable partial epilepsy, CHILD: 10-40 mg/kg/day in 3 divided doses ii) ADULT: impairment, haemodialysis, absence seizures. Avoid
Somnolence, dizziness, ataxia, weight gain,
refractory to standard anti-epileptic drugs ii) Treatment 900 mg/day in 3 equally divided doses, maximum 3600 abrupt withdrawal. Discontinuation of gabapentin
fatigue, nystagmus, tremor, diplopia, amnesia, Antacid like Maalox reduced the bioavailability of
Gabapentin 600 mg Tablet of various types of neuropathic pain, both peripheral mg/day. Initiate therapy 300 mg once on Day 1, 300 mg and or addition or substitution of alternative therapy Hypersensitivity to gabapentin
dyspepsia, asthenia, leukopenia, headache, gabapentin
(which includes diabetic neuropathy, post-herpetic twice daily on Day 2, 300 mg three times daily on Day should be gradual, over a minimum of 1 week. May
myalgia
neuralgia, trigeminal neuralgia) in adult over 18 years 3. Thereafter, the dose may be increased in 3 equally affect ability to drive or operate machinery. Potential
divided doses up to maximum 3600 mg/day for an increase in risk of suicidal thoughts or
behaviours
Contrast medium for cranial and spinal magnetic Severe renal impairment, epilepsy, hypotension,
0.1 mmol/kg body weight (equivalent to 0.2 ml/kg body Headache, nausea, vomiting, transient
resonance imaging (MRI) after intravenous history of hypersensitivity, asthma or allergic
weight) up to 100 kg. Above 100 kg body weight 20 ml sensations of heat, taste disturbance,
Gadodiamide 287mg (0.5 mmol/ml) Omniscan administration. The product provides contrast respiratory disorders, hepatic disease, seizzure Hypersensitive to Omniscan or its constituent Not known
is usually sufficient to provide diagnostically adequate anaphylaxis, shock, paraesthesias, dizziness,
enhancement and facilitates visualisation of abnormal disorder, sickle cell anemia. Care should taken to
contrast localized pain, serum iron level abnormal
structure or lesions in the CNS avoid extravasation
Thrombophlebitis, hypotension, headache,
The usual dose in adults, children, and neonates is 0.2
nausea, vomiting, cold/warm sensation, cardiac
mL/kg (0.1 mmol/kg) intravenously. For cranial and
arrest, chest pain, syncope, tachycardia,
spinal imaging, a further dose of 0.2 mL/kg (0.1
History of asthma, allergic conditions, severe renal erythema multiforme, injection site pain,
mmol/kg) may be given within 30 minutes if necessary;
insufficiency, sickle cell anaemia, chronic haemolytic nephrogenic systemic fibrosis, rash, diarrhea,
Gadopentetate Dimeglumine 469 i) Cranial and spinal magnetic resonance imaging ii) in adults this second dose may be 0.4 mL/kg (0.2
Magnevist anaemia, history of seizure disorder, gastrointestinal excessive salivation, flatulence, gastrointestinal Hypersensitivity to gadopentetate products Not known
mg/ml Whole body magnetic resonance imaging mmol/kg). For whole body imaging in adults and
disorders, hemodialysis patients, thrombotic irritation, nausea, stomach ache, taste sense
children over 2 years, a dose of 0.4 mL/kg (0.2
syndrome altered, vomiting, xerostomia, anxiety, asthenia,
mmol/kg) may be needed in some cases to produce
dizziness, headache, paresthesia, seizure,
adequate contrast and in special circumstances a dose
somnolence, conjunctivitis, cough, dyspnea,
of 0.6 mL/kg (0.3 mmol/kg) may be used in adults
nasal discharge, sneezing, throat irritation
The recommended dose is 0.1 mmol/kg (equivalent to Experience of warmth, coldness pain at site of
Hypersensitive with contrast media, have history of
High risk patients undergoing Magnetic Resonance 0.2 mL/kg in adults, children and infants. In injection, nausea, vomiting, erythema, loss of
Gadoterate Meglumine (Gadoteric allergy reaction, severe renal failure, treated with
Dotarem Imaging for cerebral and spinal disease, diseases of angiography, depending on the results of the consciousness, malaise, urticaria, hypotension, Hypersensitive to gadolinium salts Allopurinol, Atorvastatin, Emla
Acid) 0.5 mmol/ ml Injection beta blocker, had convulsion and being treated for
the vertebral column and other whole body pathology examination being performed, a second injection may cardiogenic shock, pharyngeal oedema,
epilepsy
be administered during the same session if necessary epistaxis, procedural complication
Pregnancy and premature babies, lactation.

Not for oral ingestion and avoid eye contact.
Avoid in patients with a history of epilepsy (e.g.
Dermatological disorders, excoriated skin, elderly. Seizures, dermatitis, dizziness, eczema, papular
HIV, history of head trauma or prior seizure, CNS
Simultaneous use of lindane lotion and other lesions, itching, Henoch- Schonlein purpura,
Gamma Benzene Hexachloride 0.1 % Apply lotion to entire body from neck down for 8 to 12 tumor, excessive alcohol consumption) or who
Lindane Scabies creams, ointments or oils. CNS toxicity may be percutaneous absorption, atypical leukaemia, Not known
Lotion hours, then rinse have a low body-weight, hypersensitivity to
greater in the young; use with extreme caution in aplastic anemia and abnormal vision on the use
lindane products, Norwegian (crusted) scabies
infants, children, and pregnant and nursing mothers, of lindane cream
,other skin conditions (e.g. atopic dermatitis,
conditions which may increase the risk of seizure
psoriasis) that may increase systemic absorption

Apply a sufficient quantity of shampoo onto clean, dry Avoid in patients with a history of epilepsy (e.g.
hair; generally 1 ounce is sufficient, no more than 2 HIV, history of head trauma or prior seizure, CNS
Gamma Benzene Hexachloride 0.1% ounces should be used. Work the shampoo into hair tumor, excessive alcohol consumption) or who
Lindane Head lice creams, ointments or oils. CNS toxicity may be percutaneous absorption, atypical leukaemia, Not known
in Oil Solution thoroughly and allow to remain on hair for 4 minutes. have a low body-weight, hypersensitivity to
Add small quantities of water and massage until a good lindane products, Norwegian (crusted) scabies
lather forms. Rinse thoroughly and towel dry briskly ,other skin conditions (e.g. atopic dermatitis,

Avoid in patients with a history of epilepsy (e.g.
Apply on dry and cool skin and leave for 6 - 8 hours HIV, history of head trauma or prior seizure, CNS
Gamma Benzene Hexachloride 1% before washing off. Only 1 application is necessary. In tumor, excessive alcohol consumption) or who
Lindane Only for scabies in adult creams, ointments or oils. CNS toxicity may be percutaneous absorption, atypical leukaemia, Not known
Cream children under 2 yrs, use Gamma Benzene have a low body-weight, hypersensitivity to
Hexachloride cream 0.5%, with caution lindane products, Norwegian (crusted) scabies
,other skin conditions (e.g. atopic dermatitis,
Treatment of cytomegalovirus (CMV) disease in Initial: 5 mg/kg infused over 1 hour 12 hourly for 14 - 21
Pre-existing cytopenias. Maintain adequate Probenecid, zidovudine, imipenem-cilastatin,
Ganciclovir Sodium 546 mg/10 ml immunocompromised patients, prevention of CMV days (CMV retinitis treatment) or 7 - 14 days (CMV Fever, rash, leucopenia, thrombocytopenia, Pregnancy, lactation, patients with neutrophil
Cymevene hydration of patients. Impaired renal function. High didanosine, imipenem /cilastatin, mycophenolate
Injection disease during immunosuppressive therapy following disease prevention). Long term maintenance: 6 mg/kg anaemia, decreased blood sugar count less than 500 cells/mcL
pH (9 - 11) of reconstituted solution mofetil
organ transplantation daily for 5 days/week or 5 mg/kg daily for 7 days/week
Nausea, headache, injection site reactions,
Prevention of premature luteinizing hormone surges in Given by SC 0.25 mg once daily, starting on day 6 of Pregnancy and lactation, moderate to severe May require dose adjustments of exogeneous
Women with active allergic conditions or a history of ovarian hyperstimulation syndrome, abdominal
Ganirelix 0.25 mg/0.5 ml Injection Orgalutran women undergoing controlled ovarian hyperstimulation ovarian stimulation and continued until ovulation renal or hepatic impairment, severe allergic gonadotrophins when used during controlled
allergies pain, vaginal bleeding, dizziness, malaise,
for assisted reproduction technique induction condition ovarian hyperstimulation
congenital abnormalities
i) Locally advanced or metastatic non-small cell lung i) Alone or with cisplatin: 1000 mg/m2 day 1 & 8 every 3
cancer ii) Locally advanced or metastatic pancreatic weeks or 1000 mg/m2 day 1, day 8, day 15 every 4
cancer iii) In combination with carboplatin in the weeks ii) Initially 1000 mg/m2 weekly for 7 weeks
Flu-like symptoms, proteinuria, nausea, vomiting,
treatment of patients with recurrent epithelial ovarian followed by 1 week rest. Subsequent cycles 1000 mg/
myelosuppression, oral soreness, rash, pruritus,
carcinoma, who have relapsed more than six months, m2 weekly for 3 weeks followed by 1 week rest iii) Caution in hepatic dysfunction, myelosuppression,
elevation of liver enzymes, haematuria, Hypersensitivity to gemcitabine. Pregnancy, Increased risk of infection by live vaccines.
Gemcitabine HCl 1 g Injection Gemzar following platinum-based therapy iv) In combination Gemcitabine 1000 mg/m2 as 30 minutes IV infusion renal impairment. Avoid prolonging infusion times
dyspnoea, allergic reactions, myalgia, alopecia, lactation Cisplatin, etoposide, radiotherapy
with paclitaxel for treatment of patients with metastatic day 1 & 8 of each 21-day cycle followed by carboplatin more than 60 minutes
diarrhoea, haemolytic uraemic syndrome, adult
breast cancer who have relapsed following adjuvant/ on day 1 to attain a target AUC of 4 mg/ml/minute iv)
respiratory distress syndrome
neoadjuvant chemotherapy. Prior chemotherapy 1250 mg/m2 on days 1 and 8 of each 21-day cycle with
should have included an anthracycline unless clinically paclitaxel 175 mg/m2 given as a 3-hour infusion before
contraindicated gemcitabine on day 1 of each 21-day cycle
i) Locally advanced or metastatic non-small cell lung i) Alone or with cisplatin: 1000 mg/m2 day 1 & 8 every 3
cancer ii) Locally advanced or metastatic pancreatic weeks or 1000 mg/m2 day 1, day 8, day 15 every 4
cancer iii) In combination with carboplatin in the weeks ii) Initially 1000 mg/m2 weekly for 7 weeks
Flu-like symptoms, proteinuria, nausea, vomiting,
treatment of patients with recurrent epithelial ovarian followed by 1 week rest. Subsequent cycles 1000 mg/
myelosuppression, oral soreness, rash, pruritus,
carcinoma, who have relapsed more than six months, m2 weekly for 3 weeks followed by 1 week rest iii) Caution in hepatic dysfunction, myelosuppression,
elevation of liver enzymes, haematuria, Hypersensitivity to gemcitabine. Pregnancy, Increased risk of infection by live vaccines.
Gemcitabine HCl 200 mg Injection Gemzar following platinum-based therapy iv) In combination Gemcitabine 1000 mg/m2 as 30 minutes IV infusion renal impairment. Avoid prolonging infusion times
dyspnoea, allergic reactions, myalgia, alopecia, lactation Cisplatin, etoposide, radiotherapy
with Paclitaxel, for treatment of patients with metastatic day 1 & 8 of each 21-day cycle followed by carboplatin more than 60 minutes
diarrhoea, haemolytic uraemic syndrome, adult
breast cancer who have relapsed following adjuvant/ on day 1 to attain a target AUC of 4 mg/ml/minute iv)
neoadjuvant chemotherapy. Prior chemotherapy 1250 mg/m2 on days 1 and 8 of each 21-day cycle,
should have included an anthracycline unless clinically with paclitaxel 175 mg/m2 given as a 3-hour infusion
contraindicated before gemcitabine on day 1 of each 21-day cycle
Vaginal bleeding, mild uterine pain,
Obstructive airway disease, elevated intraocular Hypersensitivity to gemeprost or other
gastrointestinal disturbances, headache, muscle
Gemeprost (Prostagladin E1 Synthetic Cervical dilatation: 1 pessary 3 hourly before surgery to pressure, cervicitis or vaginitis, ulcerative colitis, prostagladin derivatives. Acute pelvic
Cervagem Inducing abortion in the first trimester weakness, dizziness, flushing, chills, backache, Not known
Analogue) 1 mg Pessary a max of 5 pessaries over 24 hours cardiovascular disease, renal or hepatic disease. inflammatory disease and uterine scars Induction
dyspnoea, chest pain, palpitations and mild
Patients with hypertension or hypotension of labour or cervical softening at term
pyrexia. Anapylactic reactions (rare)
Dizziness, chest pain, fatigue, rash, pruritis,
Cholelithiasis, concomitant use of anticoagulants Co-admin with repaglinide may lead to an
dermatitis, urticaria, pain in extremities,
and hydroxymethylglutaryl coenzyme A (HMG-CoA) increase in the serum levels of repaglinide. May
ADULT: 1200 mg/day in 2 divided doses, 30 minutes abdominal and epigastric pain, diarrhoea, Hypersensitivity to gemfibrozil, severe hepatic or
Treatment of hyperlipoprotinaemias (TYPES IIA, IIB, III, reductase inhibitor (statin) risk of rhabdomyolysis. enhance the effects of oral anticoagulants. May
Gemfibrozil 300 mg Capsule Lopid before breakfast and dinner. Dose range from 0.9-1.5 g vomiting, flatulence, gout, headache, renal dysfunction, gall stones, neonates,
IV, V) Diabetes, hypothyroidism, not recommended for also increase the plasma concentrations of
daily paraesthesia, blurred vision. Myalgia, children, pregnancy, lactation
patients with type IIa hyperlipidemia (low-density ciclosporin and associated nephrotoxicity when
rhabdomyolysis especially when coadministered
lipoproteins cholesterol elevations only) used concurrently
with a statin
Hypersensitivity to gentamicin or other
Gentamicin 0.1% Cream Garamycin For localised infections Apply 2 - 3 times daily Discontinue if irritation or sensitization occurs Avoid prolonged use Not known
aminoglycosides
Contact lens users, overgrowth of non-susceptible
Non-specific conjunctivitis, conjunctival epithelial
organisms on prolonged use, discontinue if irritation
defect and hyperemia, temporary burning
Broad spectrum antibiotic in superficial eye infections 1 - 2 drops every 4 hours, in severe infection dosage or sensitization occurs, pre-existing renal, vestibular, Hypersensitivity to Gentamicin or
Gentamicin 0.3% Eye Drops Garamycin sensation (rare), irritation, stinging, itching and Not known
and also for Pseudomonas aeruginosa may be increased up to 2 drops every hour or auditory impairment, concomitant anesthesia, risk aminoglycosides products
dermatitis,hypokalemia, hypomagnesemia,
for neuromuscular blockade, respiratory paralysis,
hypocalcemia
concomitant neurotoxic, ototoxic, nephrotoxic drugs

Conjunctivitis, blepharitis, blepharo-conjunctivitis, defect and hyperemia, temporary burning
or sensitization occurs, pre-existing renal, vestibular, Hypersensitivity to Gentamicin or
Gentamicin 0.3% Eye Ointment Garamycin keratitis, keratoconjunctivitis, episcleritis, dacrocystitis, Apply into the conjunctival sac 3 - 4 times daily sensation (rare), irritation, stinging, itching and Not known
or auditory impairment, concomitant anesthesia, risk aminoglycosides products
corneal ulcers, styes and infected eye socket dermatitis,hypokalemia, hypomagnesemia,
hypocalcemia

defect and hyperemia, temporary burning
Broad spectrum antibiotic in superficial eye infections or sensitization occurs, pre-existing renal, vestibular, Hypersensitivity to Gentamicin or
Gentamicin 3% Fortified Eye Drops - Dose according to the needs of the patient sensation (rare), irritation, stinging, itching and Not known
and also for Pseudomonas aeruginosa or auditory impairment, concomitant anesthesia, risk aminoglycosides products
dermatitis,hypokalemia, hypomagnesemia,
hypocalcemia
Toxic side-effects are not anticipated since after

Treatment of chronic osteomyelitis of post-traumatic,
Gentamicin 7.5 mg Beads Septopal 7.5 - 22.5 mg chains to fill affected cavity Not known use of Septopal chains only extremely low Established gentamicin intolerance Not known
post-operative or hematogenous origin
gentamicin concentrations are found in serum
Known hypersensitivity. Patients with pre- Concurrent or sequestial administration with

ADULT: 3 - 5 mg/kg/day 8 hourly IM or IV. CHILD up to Vestibular& auditory toxicity, renal toxicity,
Gentamicin Sulphate 20 mg/2 ml Pregnancy, patients with reduced renal function, existent vestibular& or cochlear disease. potent antidiuretics, anaesthetics, neuromuscular
Garamycin Infections due to susceptible organisms 2 weeks: 3mg/kg every 12 hours; 2 weeks - 12 years: 2 neuromuscular blockade, superinfection,
Injection myasthenia gravis or Parkinson Administration of other ototoxic or nephrotoxic blockers, other aminoglycosides, polymyxin,
mg/kg 8 hourly nausea, vomitting, rash, blood disorders
antibiotics. Pregnancy and lactation amphotericin B, mannitol, cephalosporins
Known hypersensitivity. Patients with pre- Concurrent or sequestial administration with

ADULT: 3 - 5 mg/kg/day 8 hourly IM or IV. CHILD up to Vestibular& auditory toxicity, renal toxicity,
Gentamicin Sulphate 80 mg/2 ml Pregnancy. Patients with reduced renal function, existent vestibular& or cochlear disease. potent antidiuretics, anaesthetics, neuromuscular
Garamycin Infections due to susceptible organisms 2 weeks: 3mg/kg every 12 hours; 2 weeks - 12 years: 2 neuromuscular blockade, superinfection,
Injection myasthenia gravis or Parkinson Administration of other ototoxic and/or blockers, other aminoglycosides, polymyxin,
mg/kg 8 hourly nausea, vomitting, rash, blood disorders
nephrotoxic antibiotics. Pregnancy and lactation amphotericin B, mannitol, cephalosporins
Inflammatory and allergic conditions involving

Gentamicin Sulphate and superficial eye structures and when bacterial infection Prolonged use in infants. May impair ability to drive Rise in intraocular pressure, corneal ulcers.
Hypersensitivity to any of the components or to
Betamethasone Disodium Phosphate Garasone is present : conjunctivitis, blepharitis, keratitis, 2 drops 3 - 4 times daily or operate machinery. Pregnancy. Withdraw if there Rarely, acute sensitization to neomycin, optic Not known
other aminoglycosides
Eye Drops episcleritis, dacryocystitis, hordeolum, meibomianitis, is spread of infection nerve damage, visual acuity and field defects
injuries involving anterior segment of the eye
Inflammatory and allergic conditions involving

Gentamicin Sulphate and superficial eye structures and when bacterial infection Prolonged use in infants. May impair ability to drive Rise in intraocular pressure, corneal ulcers.
Hypersensitivity to any of the components or to
Betamethasone Disodium Phosphate Garasone is present : conjunctivitis, blepharitis, keratitis, Thin coating of ointment 3 - 4 times daily or operate machinery. Pregnancy. Withdraw if there Rarely, acute sensitization to neomycin, optic Not known
other aminoglycosides
Eye Ointment episcleritis, dacryocystitis, hordeolum, meibomianitis, is spread of infection nerve damage, visual acuity and field defects
injuries involving anterior segment of the eye
Range: 2.5 - 15 mg daily (with or immediately after Elderly, mild and moderate hepatic and renal Gastrointestinal disturbance, blood dyscrasia, Alcohol, beta blockers, biguanides, MAOIs,
Diabetes mellitus type 1, diabetic coma, severe
Glibenclamide 5 mg Tablet Daonil Diabetes mellitus type 2 breakfast). Initially 2.5 mg daily increasing by 2.5 mg impairment. Cross-sensitivity to sulphonamides and increase appetite, weight gain, skin rashes, sulphonamides, thyroid hormone, ACE inhibitor,
renal or renal impairment, pregnancy
required for metabolic control. Max: 15 mg daily its derivatives pruritus, hypersensitivity reaction analgesic
Potentiates hyperglycaemia with danazol,
chlorpromazine, glucocorticoids, progestogens,
Diabetes type 1. Severe renal or hepatic beta 2 agonist. Potentiated hypoglycaemic effect
Hepatic and or renal impairment. Hypoglycaemia insufficiency, diabetic ketoacidosis, diabetic with sulfonamides, salicylates, phenylbutazone,
Gliclazide 30 mg Modified Release 30 mg daily, adjust according to response every 4 Nausea, headache, rashes and gastrointestinal
Diamicron MR Diabetes mellitus type 2 may occur with reduced dietary intake or too high precoma. Pregnancy and lactation. Avoid beta-blockers, alcohol, H2 antagonists, NSAIDs,
Tablet weeks, max 120 mg daily disturbances. Rarely, haematological disorders
doses concomitant treatment with miconazole ACE inhibitors, MAOIs, fluconazole,
preparation ketoconazole and miconazole. Diminished
hypoglycaemic effect with thiazide diuretics,
corticosteroids and oestrogens
Potentiates hyperglycaemia with danazol,
chlorpromazine, glucocorticoids, progestogens,
Diabetes type 1. Severe renal or hepatic beta2 agonist. Potentiated hypoglycaemic effect
Initially 40-80 mg daily. Total daily dose may vary from Hepatic and or renal impairment. Hypoglycaemia insufficiency, diabetic ketoacidosis, diabetic with sulfonamides, salicylates, phenylbutazone,
Nausea, headache, rashes and gastrointestinal
Gliclazide 80 mg Tablet Diamicron Diabetes mellitus type 2 80- 320 mg orally. Adjust dose according to patient's may occur with reduced dietary intake or too high precoma. Pregnancy and lactation. Avoid beta-blockers, alcohol, H2 antagonists, NSAIDs,
disturbances. Rarely, haematological disorders
individual response doses concomitant treatment with miconazole ACE inhibitors, MAOIs, fluconazole,
preparation ketoconazole and miconazole. Diminished
hypoglycaemic effect with thiazide diuretics,
corticosteroids and oestrogens
ADULT: 1 mg by SC, IM or IV. Repeat in 20 minutes if

Glucagon (Lyophilised) 1 mg/ml necessary. CHILD less than 20 kg: 0.02 to 0.03 Patients with marked depletion of liver glycogen
Glucagen Management of hypoglycaemia Gastrointestinal upset, hypersensitivity Glucagonoma, insulinoma, phaeochromocytoma Not known
Injection mg/kg/dose or 0.5mg dose SC, IM or IV. Maximum: stores
1mg/dose. CHILD greater than 20 kg: 1mg SC, IM or IV
NEWBORN below 8 kg body weight: 2 ml daily by IV
Glucometamine 150 mg Injection Jetepar For disorders in which hepatic function is impaired diluted in saline or glucose. ADULT 2-10 ml once-twice Not known Not known Not known Not known
daily by IV or infusion
Glucometamine Capsule Jetepar For disorders in which hepatic function is impaired 2 capsules 3 times daily Not known Not known Not known Not known
Irritating to skin and mucous membrane. Shelf life
20 minutes or more immersion is recommended for Nausea, drowsiness, dizziness, headache,
shortens when diluted (effective for 14-30 days
2% formulation - High level disinfection for heat endoscopes before the session and between patients airway obstruction, asthma, rhinitis, eye irritation
Glutaraldehyde Solution depending on formulations). Must wear personal Hypersensitivity to any of its component Organic matters
sensitive equipments such as endoscopes after thorough cleaning based on manufacturer and dermatitis. Skin reactions were due to
protective equipment (PPE). Preparation room must
recommendation hypersensitivity or a direct irritant effect
be well ventilated
Cause irritation when given locally, local anesthetic
Glycerin - As a lubricant and osmotic dehydrating agent Apply to area when required Mainly due to dehydration action, irritation Not known Not known
may be used before application
Administer with caution to patients with cardiac,
Hypersensitivity to any component in the
renal, or hepatic disease, diabetes, haemolytic
Glycerin 15% Eye Drops - As an adjunct in the management of acute glaucoma 1 - 2 drops as needed May damage endothelial cells of the cornea preparation, severe dehydration, severe cardiac Not known
anaemia. Long-term use of is not well tolerated and
decompensation
instillation is painful
Glycerin 25% and Sodium Chloride Frequent or prolonged use of laxatives may result in Hypersensitivity to any component in the
Ravin Constipation 1 enema as required Rectal discomfort, burning sensation Not known
15% Enema dependence preparation
Administer with caution to patients with cardiac, Hypersensitivity to any component in the
Glycerin with Spirit 33% w/w Ear
- To relieve oedematosus otitis externa 2 - 3 drops 3 - 4 times daily renal, or hepatic disease, diabetes, haemolytic Not known preparation, severe dehydration, severe cardiac Not known
Drops
anaemia decompensation
Severe hepatic , renal impairment, hypothyroidism,
malnutrition, hypothermia. Cerebrovascular disease, Flushing, dizziness,throbbing headache,
lung disease or cor pulmonale, pregnancy, lactation, vomiting, restlessness, blurred For sublingual:Severe anaemia, early myocardial
Prophylaxis and treatment of angina and left ventricular glaucoma, mitral valve prolapse, cardiac tamponade, vision,tachycardia,bradycardia , hypotension infarction, increased intracranial pressure,
Glyceryl Trinitrate 0.5 mg Tablet Angised 0.5-1 mg sublingually Imipramine, atropine, nitrates and sildenafil
failure syncope. Avoid prolonged excessive hypotension. (which can be severe), syncope, and cyanosis symptomatic hypotension, hypersensitivity to
Nitrate-free interval is recommended in patients on rarely),methaemoglobinaemia, respiratory organic nitrates
continuous treatment with nitrates to reduce the risk impairment
of tolerance
Flushing, dizziness, tachycardia and throbbing Hypotensive effect enhanced by alcohol, beta
Severe renal or hepatic impairment. Need to be
Initial 5 mcg/min delivered via infusion pump. headache. Large doses cause vomiting, For IV :Constrictive pericarditis, pericardial blockers, antihypertensives, tricyclic
diluted for infusion via approved administration sets
Prophylaxis and treatment of angina, left ventricular Subsequent titration must be adjusted to clinical restlessness, blurred vision, hypotension (which tamponade, restrictive cardiomyopathy, antidepressants, narcotics, sildenafil. May
Glyceryl Trinitrate 25 mg/5 ml Injection Nitro-bid only. Absorption by plastics & filters. Nitrate-free
failure. Not for direct IV injection. situation with dose increment becoming more cautious can be severe), syncope and rarely cyanosis symptomatic hypotension, hypersensitivity to potentiate effects of antihistamines,
interval is recommended in patients on continuous
as partial response is seen. and methaemoglobinaemia, impairment of organic nitrates anticholinergics. Antagonises pressor action of
treatment with nitrates to reduce the risk of tolerance
respiration and bradycardia sympathomimetics
Hepatic impairment: since any absorption and
Systemic absorption can lead to disturbances of
The dosage depends on the extent of the procedure consequent metabolism may cause
Glycine 1.5% Irrigating Solution - Bladder irrigation during genitourinary surgery fluid and electrolyte balance and cardiovascular Anuric patients Not known
and its duration hyperammonaemia cardiopulmonary or renal
and pulmonary disorders
dysfunction.
Cisapride, with other anticholinergics or
medications with anticholinergic activity, such as
Dry mouth, blurred vision, tachycardia, urinary
Autonomic neuropathy, children and elderly patients, phenothiazines, antiparkinson drugs, or tricyclic
retention, constipation, severe allergic reactions
i) ADULT: 0.2 - 0.4 mg by IV before anaesthesic congestive heart failure, coronary heart disease, Glaucoma, obstructive uropathy, GI obstruction, antidepressants, may intensify the
i) To reduce secretions (respiratory tract) for certain including anaphylactic/anaphylactoid reactions;
induction or intraoperatively. CHILD: 4-8 mcg/kg up to a hypertension, hyperthyroidism, ileostomy or myasthenia gravis, hypersensitivity to antimuscarinic effects and may result in an
Glycopyrrolate 200 mcg/ml Injection - types of surgery ii) Reversal of neuromuscular block in hypersensitivity; urticaria, pruritus, dry skin, and
max of 200 mcg (0.2 mg) by IV ii) 0.2 mg by IV for each colostomy, mild hepatic or renal disease, prostatic glycopyrrolates newborns less than 1 month of increase in anticholinergic side effects.Post-
patients where atropine is contraindicated other dermal manifestations; some degree of
1 mg of neostigmine or 5 mg pyridostigmine hypertrophy, tachyarrythmia, tachycardia. May age marketing reports have included cases of heart
mental confusion and/or excitement, especially in
cause heat prostration, neuromuscular blockade block and QTc interval prolongation associated
elderly
with the combined use of glycopyrrolate and an
anticholinesterase
Initially may increase bone pain, increase serum
testosterone levels, and worsen symptoms of
Pregnancy, lactation, hypersensitivity to
Prostate cancer,endometriosis,leiomyoma uteri and prostatic cancer.Isolated cases of spinal cord
Bone pain, hot flashes, gynecomastia, goserelin products, leutenizing hormone-
assissted reproduction,breast cancer in compression and renal impairment from ureteral
Goserelin 3.6 mg Depot Injection Zoladex 3.6 mg depot injection every 28 days impotence, breakthrough bleeding, deep venous releasing hormon (LHRH) or LHRH analogues. Not Known
premenopausal and perimenopausal women suitable obstruction have occurred.History of prior treatment
thrombosis, depression, imsomnia Depot injection of 10.8 mg is contraindicated in
for hormonal manipulation that may have resulted in bone mineral density loss
women
or patients with increased risk factors for decreased
bone mineral density
Headache, asthenia, fever, pain, bradycardia,
ADULT 1 mg twice daily or 2 mg once daily with the first
Prevention and treatment of nausea and vomiting Subacute intestinal obstruction, pregnancy and constipation, nausea, leukopenia, Hypersensitivity to granisetron and other 5-HT3
Granisetron HCl 1 mg Tablet Kytril dose to be administered within 1 hour prior to cytostatic Cytochrome P450 effect (minor). Apomorphine
associated with chemotherapy and radiotherapy lactation, liver disease thrombocytopenia, hypersensitivity reaction, receptor antagonists
therapy. Maximum 9 mg/day
transiet increases in liver enzymes, rash
i) ADULT 1-3 mg as an IV bolus not not less than 30
Headache, asthenia, fever, pain, bradycardia,
i) Prevention and treatment of nausea and vomiting seconds; maximum 9 mg/day. CHILD over 2 years; Hypersensitivity to granisetron and other 5-HT3
Subacute intestinal obstruction, pregnancy and constipation, nausea, leukopenia,
Granisetron HCl 3 mg/3 ml Injection Kytril associated with chemotherapy and radiotherapy ii) Post- single dose of 10-40 mcg/kg as an IV infusion; receptor antagonists. Injection contains benzyl Cytochrome P450 effect (minor). Apomorphine
lactation, liver disease thrombocytopenia, hypersensitivity reaction,
operative nausea and vomiting maximum 3 mg/day ii) ADULT 1 mg by slow IV injection alcohol and should not be used in neonates
transiet increases in liver enzymes, rash
over 30 seconds prior to induction of anaesthesia
Oral thrush, gastrointestinal distress, taste Absorption reduced by barbiturates.

Ability to drive and operate machinery may be
ADULT: 500 mg daily up to 1 g daily in divided doses, perversion, dizziness, confusion, headache, Effectiveness reduced by liver enzyme inducing
Griseofulvin (Ultramicrosize 125 mg = Dermatophyte infections of the skin, scalp, hair and impaired. Lactation. May damage sperm cells - male Established porphyria, hepatocellular failure,
Fulcin CHILD: 10 mg/kg daily in divided doses or as a single depression, insomnia, fatigue, peripheral neuritis, drugs. Decreases anticoagulant effect of
250 mg Microsize) Tablet nails, where topical therapy has failed or inappropriate should not father children within 6 month of SLE and related conditions, pregnancy
dose photosensitivity, skin rashes, urticaria, erythema warfarin. Reduces effectiveness of oral
treatment
multiforme, leucopaenia, proteinuria contraceptive. Enhancement of effects of alcohol
Oral thrush, gastrointestinal distress, taste Absorption reduced by barbiturates.

Ability to drive and operate machinery may be
CHILD: up to 1 year: 62.5 mg twice daily, 1 - 5 years: perversion, dizziness, confusion, headache, Effectiveness reduced by liver enzyme inducing
impaired. Lactation. May damage sperm cells - male Established porphyria, hepatocellular failure,
Griseofulvin Syrup Fulcin Dermatophyte infections 62.5 mg 3 times daily, 6 - 12 years: 125 mg 2-3 times depression, insomnia, fatigue, peripheral neuritis, drugs. Decreases anticoagulant effect of
should not father children within 6 month of systemic and related conditions, pregnancy
daily photosensitivity, skin rashes, urticaria, erythema warfarin. Reduces effectiveness of oral
treatment
multiforme, leucopenia, proteinuria contraceptive. Enhancement of effects of alcohol
Nausea, vomiting, hypotension, muscle cramps

and air embolus. Effects related to vascular
Unstable cardiovascular disease or active bleeding. Generally, drugs of low molecular weight, high
access include infection, thrombosis and
During haemodialysis and haemofiltration, heparin water solubility, low volume of distribution, low
For acute renal failure, chronic renal failure, haemorrhage. Long-term complications in
Haemodialysis Concentrate with are required to prevent clotting of the blood in the protein binding and high renal clearance are
- overhydration, intoxication, adjustment of acid-base Dose depending on clinical cases dialysed patients, some of which may relate to Not known
Acetate extracorporeal circuit. Dialysis solutions should be most extensively removed by dialysis e.g.
and electrolyte balance renal failure itself, include haemodialysis-related
warmed to body temperature with dry heat because aminoglycosides. Dialysis-induced changes in
amyloidosis, acquired cystic kidney disease and
wet heat carries a risk of microbial contamination fluids and electrolytes
accelerated atherosclerosis. Dialysis dementia is
a special hazard of aluminium overload
Nausea, vomiting, hypotension, muscle cramps
and air embolus. Effects related to vascular
Unstable cardiovascular disease or active bleeding. Generally, drugs of low molecular weight, high
access include infection, thrombosis and
During haemodialysis and haemofiltration, heparin water solubility, low volume of distribution, low
For acute renal failure, chronic renal failure, haemorrhage. Long-term complications in
Haemodialysis Concentrate with are required to prevent clotting of the blood in the protein binding and high renal clearance are
- overhydration, intoxication, adjustment of acid-base Dose depending on clinical cases dialysed patients, some of which may relate to Not known
Bicarbonate extracorporeal circuit. Dialysis solutions should be most extensively removed by dialysis e.g.
and electrolyte balance renal failure itself, include haemodialysis-related
warmed to body temperature with dry heat because aminoglycosides. Dialysis-induced changes in
amyloidosis, acquired cystic kidney disease and
wet heat carries a risk of microbial contamination fluids and electrolytes
accelerated atherosclerosis. Dialysis dementia is
a special hazard of aluminium overload
Haemophilus Influenzae Type B Immunisation of infants against Haemophilus Hypersensitivity to any components of the
Act-Hib 0.5 ml IM Presence of fever or acute infection Injection site reaction, fever Not known
Conjugate 10 mcg Vaccine Influenzae Type B vaccine
Concomitant anticoagulant use, concomitant CNS
depressant use (anaesthetics, opiates, and alcohol),
history of convulsive disorders, known allergies or
allergic reactions to drugs, manic patients,
Extrapyramidal symptoms (EPS), tardive
neuroleptic malignant syndrome, elderly patients,
dyskinesia, sedation, hypotension, tachycardia, Tramadol, fluoxetine, fluvoxamine,
impaired liver function, CV disease, thyrotoxicosis.
ADULT : 1.5 - 5 mg 2 - 3 times daily up to 30 mg daily. insomnia, anxiety, weight changes, Parkinson's disease, severe CNS depression, carbamazepine, cisapride,dicoumarol,
Parkinsonism, angle-closure glaucoma, benign
Paed : Initial: 0.05 mg/kg/day or 0.25-0.5 mg/day given anticholinergic effects, gynaecomastia, bone marrow suppression, severe cardiac or procyclidine, methyldopa, olanzapine, rifampicin,
Haloperidol 1.5 mg Tablet Serenace Schizophrenia and other psychoses prostatic hyperplasia; severe cardiac or hepatic
in 2-3 divided doses; increase by 0.25-0.5 mg every 5-7 galactorrhoea, menstrual irregularities, hepatic disease, comatose states, lithium, tricyclic antidepressants. May increase
disease, presence of acute infections or
days; maximum: 0.15 mg/kg/day. Maximum 10 mg neuroleptic malignant syndrome, arrhythmias, hypersensitivity to haloperidol. Lactation the plasma levels of haloperidol when used with
leucopaenia; hyperthyroidism; pregnancy, elderly,
seizure, jaundice, hyperpyrexia. Anxiety, clozapine or chlorpromazine
children. Patients receiving anticoagulants.
depression, anorexia, leukopaenia
Discontinue treatment upon signs of neurological
toxicity in patients taking lithium. Temperature
regulation: Impaired core body temperature
regulation may
Concomitant occur
anticoagulant use, concomitant CNS
ADULT : 1.5 - 5 mg 2 - 3 times daily up to 30 mg daily. insomnia, anxiety, weight changes, Parkinson's disease, severe CNS depression, carbamazepine, cisapride,dicoumarol,
Parkinsonism, angle-closure glaucoma, benign
Paed : Initial: 0.05 mg/kg/day or 0.25-0.5 mg/day given anticholinergic effects, gynaecomastia, bone marrow suppression, severe cardiac or procyclidine, methyldopa, olanzapine, rifampicin,
Haloperidol 5 mg Tablet Serenace Schizophrenia and other psychoses prostatic hyperplasia; severe cardiac or hepatic
in 2-3 divided doses; increase by 0.25-0.5 mg every 5-7 galactorrhoea, menstrual irregularities, hepatic disease, comatose states, lithium, tricyclic antidepressants. May increase
disease, presence of acute infections or
days; maximum: 0.15 mg/kg/day. Maximum 10 mg neuroleptic malignant syndrome, arrhythmias, hypersensitivity to haloperidol. Lactation the plasma levels of haloperidol when used with
regulation
Concomitant may occur
anticoagulant use, concomitant CNS
insomnia, anxiety, weight changes, Parkinson's disease, severe CNS depression, carbamazepine, cisapride,dicoumarol,
ADULT: IM or IV , 2 mg - 10 mg then every 4 - 8 hours Parkinsonism, angle-closure glaucoma, benign
anticholinergic effects, gynaecomastia, bone marrow suppression, severe cardiac or procyclidine, methyldopa, olanzapine, rifampicin,
Haloperidol 5 mg/ml Injection Serenace Acute psychoses and mania according to response to total maximum 18 mg daily. prostatic hyperplasia; severe cardiac or hepatic
galactorrhoea, menstrual irregularities, hepatic disease, comatose states, lithium, tricyclic antidepressants. May increase
Use in child is not recommended disease, presence of acute infections or
neuroleptic malignant syndrome, arrhythmias, hypersensitivity to haloperidol. Lactation the plasma levels of haloperidol when used with
i) By IV injection, loading dose of 5000 units (10,000 regulation may occur
units in severe pulmonary embolism) followed by
continuous infusion of 15-25 units/kg/hr. By SC injection
(for DVT) of 15,000 units every 12 hours (laboratory
monitoring on daily basis essential to adjust dose).
Small adult or child, lower loading dose then, 15-25 Heparin should be used cautiously in patients with Alprostadil, alteplase, aspirin, cefoperazone,
i) Prophylaxis and treatment of venous thrombosis and Hypersensitivity, in patients who are actively
units/kg/hr by IV infusion, or 250 units/kg every 12 allergies since it is of animal origin, renal and hepatic clopidogrel, dextran, moxalactam, reteplase,
pulmonary embolism. ii) Treatment of myocardial bleeding, or have blood dyscrasias, in patients
hours by SC injection. ii) As i), for unstable angina and disease. Hypertension during menstruation. Patients Haemorrhage, cutaneous necrosis, urokinase, warfarin, digitalis, tetracyclines,
Heparin 1000 units/ml Injection - infarction and arterial embolism. iii) Prevention of with haemophilia or other blood disorders, and in
acute peripheral arterial occlusion. iii) Prophylaxis in with indwelling catheters. Precaution must be taken thrombocytopenia, anaphylaxis, hyperkalaemia nicotine, antihistamines, ACE inhibitors,
clotting in arterial and heart surgery and for prevention cases where sufficient blood coagulation tests
general surgery, by SC injection, 5000 units 2 hour if using long-term subcutaneous heparin in pregnant analgesics, dipyridamole,drotrecogin Alfa,
of cerebral thrombosis are not available
before surgery, then every 8-12 hours for 7 days or women and bacterial endocarditis iloprost, nitrates, sibutramine
until patient is ambulant, during pregnancy (with
monitoring), 5000-10000 units every 12 hours. An
adjusted dose regimen may be used for major
orthopaedic surgery or low molecular weight heparin
may be selected
i) By IV injection, loading dose of 5000 units (10,000
units in severe pulmonary embolism) followed by
continuous infusion of 15-25 units/kg/hr. By SC injection
(for DVT) of 15,000 units every 12 hours (laboratory
monitoring on daily basis essential to adjust dose).
Small adult or child, lower loading dose then, 15-25 Heparin should be used cautiously in patients with Alprostadil, alteplase, aspirin, cefoperazone,
i) Prophylaxis and treatment of venous thrombosis and Hypersensitivity, in patients who are actively
units/kg/hr by IV infusion, or 250 units/kg every 12 allergies since it is of animal origin, renal and hepatic clopidogrel, dextran, moxalactam, reteplase,
pulmonary embolism. ii) Treatment of myocardial bleeding, or have blood dyscrasias, in patients
hours by SC injection. ii) As i), for unstable angina and disease. Hypertension during menstruation. Patients Haemorrhage, cutaneous necrosis, urokinase, warfarin, digitalis, tetracyclines,
Heparin 5000 units/ml Injection - infarction and arterial embolism. iii) Prevention of with haemophilia or other blood disorders, and in
acute peripheral arterial occlusion. iii) Prophylaxis in with indwelling catheters. Precaution must be taken thrombocytopenia, anaphylaxis, hyperkalaemia nicotine, antihistamines, ACE inhibitors,
clotting in arterial and heart surgery and for prevention cases where sufficient blood coagulation tests
general surgery, by SC injection, 5000 units 2 hour if using long-term subcutaneous heparin in pregnant analgesics, dipyridamole,drotrecogin Alfa,
of cerebral thrombosis are not available
before surgery, then every 8-12 hours for 7 days or women and bacterial endocarditis iloprost, nitrates, sibutramine
until patient is ambulant, during pregnancy (with
monitoring), 5000-10000 units every 12 hours. An
adjusted dose regimen may be used for major
orthopaedic surgery or low molecular weight heparin
may be selected
Heparin should be used cautiously in patients with Alprostadil, alteplase, aspirin, cefoperazone,
Hypersensitivity in patients who are actively
allergies since it is of animal origin, renal and hepatic clopidogrel, dextran, moxalactam, reteplase,
bleeding or have blood dyscrasias, in patients
Heparin Sodium 50 units in Sodium disease. Hypertension during menstruation. Patients Haemorrhage, cutaneous necrosis, urokinase, warfarin, digitalis, tetracyclines,
Hepsal To maintain patency of peripheral venous catheters Flush with 5 ml (50 units) every 4 hours or as required with haemophilia or other blood disorders and in
Chloride Injection with indwelling catheters. Precaution must be taken thrombocytopenia, anaphylaxis, hyperkalaemia nicotine, antihistamines, ACE inhibitors,
cases where sufficient blood coagulation tests
if using long-term subcutaneous heparin in pregnant analgesics, dipyridamole,drotrecogin Alfa,
are not available
women. Bacterial endocarditis iloprost, nitrates, sibutramine
0.5 ml per injection. ADULT and CHILD more than 15
Vaccination against hepatitis A especially in those at
years: A single primary dose followed by a booster Fatique, fever, headache, muscle or joint pain
Hepatitis A, Inactivated Vaccine 160 risk of exposure to hepatitis A virus such as: i) Visitors Hepatic disease, hypersensitivity to neomycin, avoid Fever, acute illness, chronic progressive
Avaxim dose 6 - 12 months later. CHILD 2 - 15 years: A single and gastrointestinal upset. Mild reversible rise in Immunosuppressants
antigen units Injection ii) Chronic hepatitis B and C patient iii) Those requiring IV route of administration disease, hypersensitivity
primary dose followed by a booster dose 6 - 12 months liver enzymes
vaccination against hepatitis A
later
i) Recommended dose in ADULT and CHILD more than
i) For post-exposure prophylaxis of hepatitis B ii) 10 years: A single dose of 500 units IM within 48 hours
Hepatitis B Immunoglobulin (Human) Extreme hypogammaglobulinaemia, severe Local reaction at injection site, headache,
Hyperhep/Hepabig Prophylaxis against recurrence of hepatitis B infection and not more than 1 week after exposure ii) Different Selective IgA deficiencies Live vaccines
Injection thrombocytopenia, bleeding disorders malaise, fever, nephrotic syndrome
in chronic hepatitis B post liver transplantation regimens depending on hepatitis B virus (HBV) DNA
positivity
ADULTS over 20 years: 10 mcg/dose. ADOLESCENT
11 - 19 years: 5 mcg/dose. NEWBORN and CHILD up
Pregnancy, immunodeficiency and or receiving
Immunisation against infections caused by Hepatitis B to 10 years: 2.5 mcg/dose. INFANTS born to HBsAg Fatigue, malaise, nausea, diarrhoea, reactions at
Hepatitis B Vaccine Injection B-Hepavac immunosuppresant therapy, severely compromised Hypersensitivity to any of the components Not known
virus positive mothers: 3 doses of 0.5 ml each. Second dose injection site
cardiopulmonary status
to be given after 1 month and booster dose after 6
months
Systemic toxicity especially in infants and small
children.Children with brain damage, Down's
Hypersensitivity to homatropine products,
Treatment of anterior segment inflammation. Producing syndrome. Elderly, keratoconus, avoid bright light, Transient stinging, local irritation, keratitis, pain in
Homatropine 2% Eye Drops - 1 drop 1 - 4 times daily primary glaucoma or tendency toward glaucoma Cisapride, procainamide
cycloplegia and mydriasis for refraction driving, or hazardous activity while pupils are eye, raised intraocular pressure
(e.g. narrow anterior chamber)
dilated,avoid contact with oral mucosa; wash hands
thoroughly after use
CHF precipitation, oedema, hypertension,
i) ADULT 25 g. CHILD 0.6 g/kg body weight ii) ACE inhibitors: May have increased risk of
Hepatic or renal failure due to protein load; rapid hypervolemia, hypotension, tachycardia,chills, Hypersensitivity to albumin; patients at risk for
i) Acute hypovolemic shock ii) Hypoproteinaemia iii) Maximum daily dose is 2g iii) 1 g/kg before exchange atypical reactions; withhold ACEIs for at least 24
Human Albumin Injection - infusion of albumin solutions may cause vascular fever, headache, pruritus, rash, urticaria, acute circulatory overload (cardiac failure,
Neonatal hyperbilirubinaemia transfusion. Dose is given at rate of 1 ml of 25% hours prior to plasma exchanges using large
overload nausea, vomiting, bronchospasm, pulmonary pulmonary edema, severe anemia)
solution per minute volumes of albumin
oedema, anaphylaxis
For the prevention of cervical cancer due to papilloma Acute severe febrile illness (postpone vaccination), Headache, myalgia, injection site reactions,
Human Papillomavirus (Types 16, 18) Given by IM into deltoid region. ADULT and CHILD 10 - Hypersensitivity to papillomavirus recombinant Immunosuppressants may diminish the
Cervarix virus. To be used as part of the public health program thrombocytopenia or any coagulation disorder, fatigue, nausea, vomiting, diarrhoea, abdominal
Vaccine Injection 25 years, 3 doses of 0.5 mL, at 0, 1 and 6 months vaccine or any component of the formulation therapeutic effect of vaccines (Inactivated)
only pregnancy & lactation pain, pruritus, rash, urticaria, arthralgia, fever
Pyrexia, pain in extremity, injection site reactions

(erythema, pain and swelling, pruritus),
bronchospasm, lymphadenopathy, dizziness,
For the prevention of cervical cancer due to papilloma Given by IM into deltoid region or higher anterolateral
Human Papillomavirus (Types 6, 11, Impaired immune response, thrombocytopenia or Guillain-Barre syndrome, headache, syncope, Hypersensitivity to papillomavirus recombinant Immunosuppressants may diminish the
Gardasil virus. To be used as part of the public health program thigh. ADULT and CHILD 9 - 26 years, 3 doses of 0.5
16, 18) Vaccine Injection any coagulation disorder, pregnancy & lactation nausea, vomiting, arthralgia, myalgia, asthenia, vaccine or any component of the formulation therapeutic effect of vaccines (Inactivated)
only mL, at 0, 2 and 6 months
fatigue, malaise, hypersensitivity reactions
including anaphylactic reactions, bronchospasm
and urticaria
Tachycardia, palpitation, hypotension, fluid
Concomitant treatment with other vasodilators,
retention, gastrointestinal disturbances, Idiopathic systemic lupus erythematous, severe
i) Slow IV injection, ADULT: 5-10 mg diluted with 10ml calcium antagonists, ACE inhibitors, diuretics,
headache, dizziness, systemic lupus tachycardia, high output heart failure, myocardial
sodium chloride 0.9%. May be repeated after 20-30 Hepatic impairment, renal impairment, coronary antihypertensives, tricyclic antidepressants and
Hydralazine HCl 20 mg Injection Hypertensive crisis in pregnancy erythematosus-like syndrome, abnormal liver insufficiency due to mechanical obstruction,
minutes if necessary. ii) IV infusion 200-300 artery disease, cerebrovascular disease major tranquillisers, as well as the consumption
function, jaundice, blood disorders including dissecting aortic aneurysm, cor pulmonale,
mcg/minutes. Maintenance dose 50-150 mcg/minutes of alcohol, may potentiate the blood pressure-
haemolytic anaemia, leukopenia, porphyria
lowering effect
thrombocytopenia
ADULT: Diuretics; 25-200 mg daily. Hypertension 12.5-

May enhance toxicity of digitalis glycosides,
25 mg daily CHILD: Oedema and hypertension; Metabolic disturbances, electrolyte imbalance,
neuromuscular-blocking action of competitive
Adjunct; 1 to 2 mg/kg ORALLY daily in single or two Renal or hepatic impairment, pregnancy and anorexia, gastrointestinal disturbances,
muscle relaxants, effect of antihypertensives.
divided doses; Children 2-12 years old MAX dose, not lactation, elderly, debilitated patients, syndrome headache, dizziness, postural hypotension, Anuria, concurrent lithium therapy, renal
Hydrochlorothiazide 25 mg Tablet Diuretic, hypertension Increased risk of postural hypotension with
to exceed 100 mg ORALLY daily; Infants less than 6 lupus erythematous. Monitor fluid and electrolytes, paresthesia, impotence, yellow vision, decompensation
alcohol, barbiturates, opioids. Potassium-
months old, may require doses up to 3 mg/kg ORALLY bronchial asthma hypersensitivity. Rarely cholestatic jaundice,
depleting effect enhanced by corticosteroids,
daily in two divided doses, Infants up to 2 yrs old: MAX pancreatitis, blood dyscrasias
ACTH, carbenoxolone
dose, not to exceed 37.5 mg ORALLY daily
ADULT: Diuretics; 25-200 mg daily. Hypertension 12.5-

May enhance toxicity of digitalis glycosides,
25 mg daily CHILD: Oedema and hypertension; Metabolic disturbances, electrolyte imbalance,
neuromuscular-blocking action of competitive
Adjunct; 1 to 2 mg/kg ORALLY daily in single or two Renal or hepatic impairment, pregnancy and anorexia, gastrointestinal disturbances,
muscle relaxants, effect of antihypertensives.
divided doses; Children 2-12 years old MAX dose, not lactation, elderly, debilitated patients, syndrome headache, dizziness, postural hypotension, Anuria, concurrent lithium therapy, renal
Hydrochlorothiazide 50 mg Tablet Diuretic, hypertension Increased risk of postural hypotension with
to exceed 100 mg ORALLY daily; Infants less than 6 lupus erythematous. Monitor fluid and electrolytes, paresthesia, impotence, yellow vision, decompensation
alcohol, barbiturates, opioids. Potassium-
months old, may require doses up to 3 mg/kg ORALLY bronchial asthma hypersensitivity. Rarely cholestatic jaundice,
depleting effect enhanced by corticosteroids,
daily in two divided doses, Infants up to 2 yrs old: MAX pancreatitis, blood dyscrasias
ACTH, carbenoxolone
dose, not to exceed 37.5 mg ORALLY daily
Dry skin, pruritus, irritation, mild to moderate
Hydrocortisone 1% & Neomycin 0.5% Inflammatory and pruritic manifestations of Apply to affected part 2-3 times daily (occasionally may Extensive or prolonged use, pregnancy, infant and Viral diseases, bacteria and fungal infection,
- transient burning or stinging and allergic contact Not known
Cream corticosteroid responsive dermatoses cause sensitisation to Neomycin) children less than 4 year. Avoid contact with eyes acne, rosacea and perioral dermatitis
dermatitis
Fungal and bacterial infections, tuberculosis of
Inflammatory and pruritic manifestations of Apply sparingly to affected area 2 - 3 times daily until Prolonged use in infants and children, ulceration at Local atrophic skin changes, impaired skin the skin, viral disease of the skin, acne vulgaris,
Hydrocortisone 1% Cream - Not known
corticosteroid responsive dermatoses condition improve, then reduce frequency infection site, diabetes mellitus healing rosacea, perioral dermatitis. Hypersensitivity to
hydrocortisone
Fungal and bacterial infections, tuberculosis of
Inflammatory and pruritic manifestations of Apply sparingly to affected area 2 - 3 times daily until Prolonged use in infants and children, ulceration at Local atrophic skin changes, impaired skin the skin, viral disease of the skin, acne vulgaris,
Hydrocortisone 1% Ointment - Not known
corticosteroid responsive dermatoses condition improve, then reduce frequency infection site, diabetes mellitus healing rosacea, perioral dermatitis. Hypersensitivity to
hydrocortisone
Concurrent use of barbiturates, carbamazepine,
Glucocorticoid replacement therapy in primary or phenytoin, primidone or rifampicin may enhance
secondary adrenal insufficiencies and long term ADULT: 20 - 30 mg daily in divided doses. CHILD: 10 - Discontinue treatment by reducing the dosage Fluid and electrolyte disturbances, muscle the metabolism and reduce the effects of
Hydrocortisone 10 mg Tablet - Hypersensitivity, systemic fungal infection
management of congenital adrenal hyperplasia in 30 mg daily in divided doses gradually weakness, peptic ulcer systemic corticosteroids. Oral contraceptives or
children ritonavir may increase plasma concentrations of
corticosteroids
ADULT 100 mg 1-2 times/day for 2-3 weeks. If used for Hypersensitivity, bowel obstruction and
Hydrocortisone Enema 0.1% - Adjunctive treatment for ulcerative colitis and proctitis Prolonged use, untreated infection Local irritation Not known
longer than 3 weeks, taper treatment over 2-3 weeks perforation, extensive fistulas
Concurrent use of barbiturates, carbamazepine,
phenytoin, primidone or rifampicin may enhance
Conditions responsive to systemic or local Initially 100 - 500 mg IV over 30 seconds to more than
Hydrocortisone Sodium Succinate Discontinue treatment by reducing the dosage Fluid and electrolyte disturbances, muscle the metabolism and reduce the effects of
Solu-Cortef glucocorticoid injection therapy especially in 10 minutes. Dose may be repeated at intervals of 2, 4 Hypersensitivity, systemic fungal infection
100 mg Injection gradually weakness, peptic ulcer systemic corticosteroids. Oral contraceptives or
emergencies or 6 hours
ritonavir may increase plasma concentrations of
corticosteroids
Instill 1 - 2 drops into the ear as required (leave for a Perforated eardrum, suppurative otitis media,
Hydrogen Peroxide 1.5% Ear Drops - To soften impacted ear wax Not known Not known Not known
few minutess) history of ear discharge
Hydrogen Peroxide 6% (=approx. 20 vol) shall be
dispensed. For cleansing wounds: 1.5% to 6% solution
apply 2-3 times daily or when nescessary. As a Large or deep wound, avoid normal skin, bleaches
Bleaching effect on hair, irritating burn on the Incompatible with reducing agents, including
mouthwash: rinse the mouth for 2-3 minutes with 15ml fabric. Strong solution which contain 27% and 30%
Hydrogen Peroxide 20 volume Skin disinfection, particularly cleansing and deodorising skin, mucous membrane and eye. Continued use organic matter and oxidisable substances, some
- of hydrogen peroxide 6% diluted in half a tumblerful of (100 vol) are only for the preparation of weaker Should not be used in abscesses
Solution wounds and ulcers as a mouthwash may cause reversible metals, metallic salts, iodides and
warm water 2-3 times daily. Disinfecting cleaned solution and should not be applied to tissue
hypertrophy of the papillae of the tongue permanganates
equipment: immersion for 30 minutes in 6% solution. As undiluted
ear drop for removal of wax: hydrogen peroxide 6%
diluted with 3 parts of water preferably just before use
Gastrointestinal disturbances, nausea, vomiting
Liver disease, alcoholism or concurrent
and diarrhea, headache, skin reactions,
i) Initially 400 mg daily in divided dose. Maintenance : administration with known hepatotoxic drugs. G6PD Pre-existing maculopathy, pregnancy,
i) SLE and mixed connective tissue disease for skin, bleaching of hair, alopecia, blurred vision,
Hydroxychloroquine Sulphate 200 mg 200 - 400 mg daily ii) ADULT : 400 - 600 mg daily. deficiency, renal impairment or metabolic acidosis, hypersensitivity to 4-aminoquinoline compound,
Plaquenil joint and serosa ii) Second line therapy for acute difficulty in focusing, blood dyscrasias, drug- Digoxin - increase level, metoprolol
Tablet Maintenance: 200 - 400 mg daily. CHILD : up to 6.5 patients with psoriasis or porphyria, haematologic long-term use in children, retinal or visual field
rheumatoid arthritis induced myopathy, disorder of cornea,
mg/kg daily (maximum 400mg daily) disorders. If patient develops pigmentary changes from prior 4-aminoquinoline compound
cardiovascular: Torsades de pointes,
abnormality or visual field defect, discontinue drug
agranulocytosis, retinopathy, ototoxicity (rare)
Hydroxyethyl Cellulose Jelly KY Jelly For lubricating purpose Apply sufficiently for lubricating purpose Not known Not known Not known Not known
ADULT daily dose up to 20 ml/kg/day. Normally 500-
Bleeding disorders, congestive heart failure,
1500 ml. The rate of infusion may approach 20 Elevated serum amylase levels may be observed
Therapy and prophylaxis of hypovolaemia and shock in renal failure with oliguria or anuria not related to
Hydroxyethyl Starch 6% Injection Haes-Steril ml/kg/hour in acute haemorrhagic shock, slower rates temporarily following administration. Pregnant and Not known Not known
connection with surgery trauma, infections and burns hypovolemia, known hypersensitivity to
in burns and septic shock. CHILD under 10 years 15 ml lactation
hydroxyethyl starch
/kg/hour. Do not exceed
Hypersensitivity to hydroxyprogesterone,
Asthma, migraine, epilepsy, cardiac dysfunction,
Oedema, thrombophlebitis, mental depression, carcinoma of the breast (known or suspected),
renal dysfunction, history of psychic depression,
weight changes, abdominal cramps, anorexia, undiagnosed genital bleeding, missed abortion,
Hydroxyprogesterone Caproate 250 hepatic and endocrine tests maybe altered during Requirements for oral antidiabetics and insulin
Proluton-Depot Habitual and threatened abortion 250 - 500 mg once weekly by IM injection bloating, nausea, vomiting, cervical secretions, history of thrombophlebitis and thromboembolic
mg/ml Injection treatment. Benign and rarely malignant liver tumour can change
menstrual disorders, cholestatic jaundice, disorders, history of cerebral apoplexy, genital
which may lead to life-threatening intra abdominal
pulmonary embolism, rash malignancy, liver tumours, liver tumours, history
haemorrhage had been observed
of herpes of pregnancy
i)Intermittent therapy : 80 mg/kg orally as a single dose
every 3rd day. Continuous therapy : 20 - 30 mg/kg
orally as a single dose dly. Concomitant therapy with
irradiation : 80 mg/kg orally as a single dose every 3rd Hydroxyurea is mutagenic and clastogenic. Correct
i)Solid tumours ii) Chronic myelocytic leukaemia and Myelosupression, GI disturbances, Didanosine, stavudine and zidovidine (in HIV-
day.(administration of hydroxyurea should be started at anaemia prior to initiating hydroxyurea therapy. Severe bone marrow depression , pregnancy,
myeloproliferative disease iii)Severe psoriasis eg. Hyperpigmentation, facial erythema, diffuse infected patients), fatal and non fatal pancreatitis,
Hydroxyurea 500 mg Capsule Hydrea least 7 days before initiation of irradiation and continued Exacerbation of postirradiation erythema. Elderly lactation, hypersensitivity to hydroxyurea
Extensive plaque psoriasis, erythrodermic psoriasis, maculopapular rash, headache, drowsiness, hepatotoxicity, and peripheral neuropathy. Live
during radiotherapy as well). ii)Continuous therapy (20 - patients, marked renal dysfunction, impairment of products.
pustular psoriasis -as third line therapy. confusion ,transient renal function abnormalities. vaccines, fluorouracil, methotrexate, cytarabine
30 mg/kg orally as a single dose daily, therapy should fertility.
be interrupted if the white blood cell count drops below
2500/mm3, or the platelet count below 100,000/mm3.
iii) 500 mg tds.
Sedating antihistamines may enhance the

Sleepiness, drowsiness, headache, dizziness,
Initially 25 mg at night, increased if necessary up to 25 Concomitant administration with central nervous sedative effects of CNS depressants including
weakness, depression and irritability, dry mouth,
mg 3-4 times daily. ADULT and CHILD more than 10 system depressants, asthma, dose adjustment in Pregnancy, breastfeeding and hypersensitivity alcohol, barbiturates, hypnotics, opioid
Hydroxyzine HCl 25 mg Tablet Atarax Allergic pruritus chest tightness, tremor, convulsions,
years : 50 - 75 mg; 6 - 10 years: 25 - 50 mg; 1 - 5 liver disease. Avoid driving and operating machinery. reaction analgesics, anxiolytic sedatives and
hypersensitivity reactions (wheezing, shortness
years: 12.5 - 25 mg; to be taken daily in divided doses Lactation, ECG abnormalities, porphyria antipsychotics. Have an additive antimuscarinic
of breath)
action with other antimuscarinic drugs
Sedative effects enhanced by alcohol.
Cardiovascular disease, avoid in the elderly, Tachycardia, mydriasis, dry mouth, CNS History of hypersensitivity to hyoscine.
Hyoscine Hydrobromide 400 mcg/ml 200-600 mcg given as SC or IM 60 minutes before Concurrent administration with MAOIs, tricyclic
- To reduce oral secretions before surgery paralytic ileus, myasthenia gravis, epilepsy, prostatic depression, urinary urgency, weakness, blurred Porphyria, closed-angle glaucoma, urinary
Injection induction of anaesthesia. CHILD: 15 mcg/kg antidepressant, antihistamine, amantadine can
enlargement vision, ataxia retention
potentiate antimuscarinic effect of hyoscine
Intensifies anticholinergic effects of tricyclic
Geriatric and pediatric patients, pregnancy,
antidepressants, antihistamines, quinidine,
breastfeeding, intestinal atony, paralytic ileus and Xerostomia, dyshidrosis, tachycardia, urinary Obstructive disease of the gastrointestinal or
amantadine and disopyramide. Enhances
Hyoscine N-Butylbromide 1 mg/ml Gastrointestinal tract and genito-urinary tract spasm, ulcerative colitis, coronary artery diseases, hesistancy and retention, allergic reactions, skin urinary tract, narrow-angle glaucoma, cardiac
Buscopan ADULT and CHILD over 6 years : 10 ml 3 times daily tachycardic effects of beta-adrenergic agents.
Liquid dyskinesia of the biliary system arrhythmias , heart failure, hypertension, xerostomia, reactions, confusions, excitement, constipation, tachyarrhythmias, myasthenia gravis, prostatic
Dopamine antagonist eg metoclopramide
hiatal hernia with reflux esophagitis, prostatic paralytic ileus hypertrophy with urinary retention
reduces effects of both drugs on gastrointestinal
hypertrophy
tract
Geriatric and pediatric patients, pregnancy,
antidepressants, antihistamines, quinidine,
breastfeeding, intestinal atony, paralytic ileus and Xerostomia, dyshidrosis, tachycardia, urinary Obstructive disease of the gastrointestinal or
amantadine and disopyramide. Enhances
Hyoscine N-Butylbromide 10 mg Gastrointestinal tract and genito-urinary tract spasm, ADULT 10-20 mg 3-4 times daily. CHILD 6-12 years: ulcerative colitis, coronary artery diseases, hesistancy and retention, allergic reactions, skin urinary tract, narrow-angle glaucoma, cardiac
Buscopan tachycardic effects of beta-adrenergic agents.
Tablet dyskinesia of the biliary system 10 mg 3 times daily arrhythmias , heart failure, hypertension, xerostomia, reactions, confusions, excitement, constipation, tachyarrhythmias, myasthenia gravis, prostatic
Dopamine antagonist eg metoclopramide
hiatal hernia with reflux esophagitis, prostatic paralytic ileus hypertrophy with urinary retention
reduces effects of both drugs on gastrointestinal
hypertrophy.
tract
Geriatric and pediatric patients, pregnancy, Obstructive disease of the gastrointestinal or
Xerostomia, dyshidrosis, tachycardia, urinary antidepressants, antihistamines, quinidine,
breastfeeding, intestinal atony, paralytic ileus and urinary tract, narrow-angle glaucoma, cardiac
hesistancy and retention, allergic reactions, skin amantadine and disopyramide. Enhances
Hyoscine N-Butylbromide 20 mg/ml Gastrointestinal tract and genito-urinary tract spasm, ADULT 20 - 40 mg. Max : 40 mg 6 - 8 hourly. CHILD ulcerative colitis, cardiac disease, coronary artery tachyarrhythmias, myasthenia gravis, prostatic
Buscopan reactions, confusions, excitement, constipation, tachycardic effects of beta-adrenergic agents.
Injection dyskinesia of the biliary system 0.5 mg/kg/dose diseases, arrhythmias , heart failure, hypertension, hypertrophy with urinary retention, paraben
paralytic ileus, rarely anaphylactoid reactions & Dopamine antagonist eg metoclopramide
xerostomia, hiatal hernia with reflux esophagitis, allergy (multi-dose vial for injection contains
anaphylactic shock reduces effects of both drugs on gastrointestinal
prostatic hypertrophy parabens)
tract
i) Hypogammaglobulinaemia and other deficiency
states ii) Severe refractory idiopathic thrombocytopenia i) 50 mg/kg body weight daily for 5 days, then 25 - 50
purpura (platelet less than 20,000) with internal mg/kg weekly for maintenance according to the severity
Local reaction at injection site, allergic reaction, Anaphylactic or severe systemic response to
Hyperimmune Gamma Globulin bleeding, particularly central nervous system iii) of the condition ii) 400 mg/kg daily for 5 days with a
Gamma-16 Pregnancy headache, malaise, fever, chest tightness, back human Ig. Selective IgA deficiencies who have Live virus vaccines
Injection Septicaemia in immunocompromised patients or further dose of 400 mg/kg as required iii) Septicaemia
pain known antibody against IgA
patients not responding to antibiotics iv) Chronic in immunocompromised patients or patients not
lymphocytic leukaemia not responding to conventional responding to antibiotics iv) 250 mg/kg per month
therapy
Self-prescribed use as an ocular lubricant should not
exceed 3 days, avoid contamination of the applicator
Tear deficiency, ophthalmic lubricant; for relief of dry tip through contact, remove viscoelastic solutions Hypersensitivity to hydroxypropyl
Hypromellose 0.3% Eye Drops Dacrolux 1 - 2 drops several times a day Increases in intraocular pressure, blurred vision Not known
eyes and eye irritation form the anterior chamber at the end of the surgical methylcellulose
procedure, treat emergent elevations of intraocular
pressure
Avoid contamination of the applicator tip through
Blurred vision, raised intraocular pressure,
Hypromellose 0.3%, Carbomer 980 Symptomatic relief of severe dry eye conditions and as contact, self-prescribed use as an ocular lubricant
Genteal Gel Instill 1-2 drops in affected eye(s) as needed transient, postoperatively, Sticking of eyelids Hypersensitivity to hypromellose Not known
Ophthalmic Gel lens lubricant during ophthalmic diagnostic procedures should not exceed 3 days ,treat emergent elevations
(discharge)
of intraocular pressure
Concurrent therapies with corticosteroids,
chemotherapy, radiotherapy; increased risk for Rash, abdominal pain, diarrhoea, indigestion, Hypersensitivity to ibandronate or to any of its
Treatment of postmenopausal osteoporosis to reduce osteonecrosis especially in the jaw. Creatinine nausea, arthralgia, back pain, myalgia, excipients. Inability to stand or sit upright for 60 Concurrent use with calcium and antacids may
Ibandronic Acid 150 mg Tablet Bonviva 150 mg once monthly
the risk of fracture clearance less than 35 ml/minute, vitamin D and headache, bronchitis, dyspepsia, nausea, flu-like minutes. Uncorrected hypocalcaemia, result in reduced alendronate absorption
mineral deficiencies to be corrected before initiating symptoms hypocalcaemia, esophageal reactions
therapy
Peptic ulceration, GI bleeding, headache, Coumarin-type anticoagulants, aspirin or
dizziness, nervousness, skin rash, pruritus, NSAIDs, digitalis glycosides, lithium,
Patients with active or severe peptic ulceration, tinnitus, oedema depression, drowsiness, methotrexate, diuretics, cefoperazone, valproic
ADULT : 200 - 400 mg 3 times daily after food, Patients with history of hypersensitivity to
history of bronchial asthma, renal or hepatic insomnia, blurred vision, hypersensitivity, acid, ciclosporin, gold compound, other nephrotic
Ibuprofen 200 mg Tablet Brufen Pain and inflammation in rheumatic disease maximum. 2.4 g daily CHILD : 20-30 mg/kg body weight aspirin/other NSAIDs, active peptic ulcer,
disorders, bleeding disorders, CV disease, impairment of renal function, dyspepsia, medications, probenecid. Moclobemide
daily in divided doses hypersensitivity, lactation, neonates
pregnancy and lactation thrombocytopaenia, visual disturbances, nausea, enhances effects of ibuprofen. Increased risk of
vomiting, epigastric pain, heartburn, jaundice, gastrointestinal bleeding with warfarin. Lost of BP
hepatitis, depression response with ACEI
2 - 3 drops 3 - 4 times daily and in ear wick for otitis Slightly irritant to skin, if excessive can impair Allergy and hypersensitivity to any of its
Ichthammol Glycerin 10% Ear Drops - Ear wick for otitis externa with oedema Not known Not known
externa hearing ability component
Risk for cardiotoxicity increased in elderly,
hypertension, heart disease, previous treatment with
i) Induction phase: 12 mg/m2 IV slow bolus on Days 3, anthracyclines, previous chest radiotherapy. Cardiotoxicity, myelosuppression, nausea,
i) Acute promyelocytic leukaemia ii) Relapse Acute Probenecid, sulfinpyrazone, heparin. Live
5 and 7. Consolidation phase, month 1: 12 mg/m2 IV on Cumulative doses more than 150 mg/m2 are vomiting, diarrhoea, mucositis, alopecia, rash, Hypersensitivity to idarubicin and other
myeloid leukemia (with sibling match) iii) Acute myeloid vaccine, other myelosuppressants,
Idarubicin 10 mg Injection Zavedos Days 1 and 2. Repeat monthly for 3 courses ii) 12 associated with decreased left ventricular ejection photosensitivity, hyperpigmentation, vesicant, anthracyclines. Pregnancy, lactation, cardiac
leukemia, acute lymphoblastic leukemia (salvage azidamfenicol, chloramphenicol, ciclosporin,
mg/m2 D1-3 iii) 12 mg/m2 D1-3 as part of FLAG-IDA fraction. Monitor cardiac function. Caution against discolouration of urine, leukopenia, impairment, renal and hepatic impairment
therapy) trastuzumab
regimen sun exposure. Avoid extravasation. Anticipate and thrombocytopenia
prevent tumour lysis syndrome. Caution with
abnormal liver function tests
Risk for cardiotoxicity increased in elderly,
hypertension, heart disease, previous treatment with
i) Induction phase: 12 mg/m2 IV slow bolus on Days 3, anthracyclines, previous chest radiotherapy. Cardiotoxicity, myelosuppression, nausea,
i) Acute promyelocytic leukaemia ii) Relapse Acute Probenecid, sulfinpyrazone, heparin. Live
5 and 7. Consolidation phase, month 1: 12 mg/m2 IV on Cumulative doses more than 150 mg/m2 are vomiting, diarrhoea, mucositis, alopecia, rash, Hypersensitivity to idarubicin and other
myeloid leukemia (with sibling match) iii) Acute myeloid vaccine, other myelosuppressants,
Idarubicin 5 mg Injection Zavedos Days 1 and 2. Repeat monthly for 3 courses ii) 12 associated with decreased left ventricular ejection photosensitivity, hyperpigmentation, vesicant, anthracyclines. Pregnancy, lactation, cardiac
leukemia, acute lymphoblastic leukemia (salvage azidamfenicol, chloramphenicol, ciclosporin,
mg/m2 D1-3 iii) 12 mg/m2 D1-3 as part of FLAG-IDA fraction. Monitor cardiac function. Caution against discolouration of urine, leukopenia, impairment, renal and hepatic impairment
therapy) trastuzumab
regimen sun exposure. Avoid extravasation. Anticipate and thrombocytopenia
prevent tumour lysis syndrome. Caution with
abnormal liver function tests
Alopecia, myelosuppression, nausea and
i) 1.2 - 2.4 g/m2/day for 3 - 7 days as a 30 - 120 vomiting, diarrhoea, mucositis, transient
Brain metastases, electrolyte imbalance, hepatic and
minutes infusion. Alternatively, can also be given as a abnormalities of liver enzymes, acute
renal impairment. Hydration required. Renal function
single high dose, eg. 5 g/m2 in a 24 hour infusion. hepatocellular injury (not common at standard Hypersensitivity to ifosfamide, pregnancy,
Ifosfamide 1 g Injection Holoxan i) Solid tumours ii) Leukaemia iii) Lymphoma should be checked prior to administration. Co- Phenobarbital, carbamazepine, phenytoin
Cycles may be repeated every 3 - 4 weeks ii) CHILD: doses), erythematous rash, pruritis, pigmentary lactation. Severe myelosupression
administration with mesna, which is a urothelial
400 - 3000 mg/m2/day for 3 - 5 days according to changes, photosensitivity, acute renal failure
protective agent is mandatory
protocol iii) Refer to protocols (high dose), headache, drowsiness, dizziness,
encephalopathy/ acute confusion (high dose)
i) ADULT: Chronic phase chronic myeloid leukemia:
i) ADULT and CHILD: Philadelphia positive (Ph+) Hepatic or severe renal impairment. History of
400 mg once daily. Accelerated phase or blast crisis Myelosuppression, gastrointestinal disturbances, Alfuzosin, aprepitant, carbamazepine,
chronic myeloid leukaemia in chronic phase and in cardiac disease. Severe fluid retention may occur. It
chronic myeloid leukemia: 600 mg once daily. CHILD eczema, rash, myalgia, arthralgia, fluid retention, dexamethasone, ketoconazole, levothyroxine,
early acceleration after failure of interferon therapy ii) is recommended that patients be weighed regularly. Hypersensitivity to imatinib or any component of
Imatinib Mesylate 100 mg Tablet Glivec more than 2 years, chronic myeloid leukemia: 340 pneumonia, cardiac failure and hepatic failure, phenobarbital, phenytoin, rifampin, simvastatin,
Treatment of patients with unresectable and or Regular monitoring of complete blood counts and the product. Avoid pregnancy and lactation
mg/m2 daily. Max: 60 mg/day ii) Unresectable and or gynaecomastia (due to reduced testosterone), St John's Wort, warfarin, ciclosporin and
metastatic, malignant gastrointestinal stromal tumours liver function tests. Children less than 3 year.
metastatic, malignant gastrointestinal stromal tumours vomiting, nausea paracetamol
(GIST) who are positive for CD117/c-kit Pregnancy, lactation (avoid)
GIST: 400 mg/day
i) ADULT: Chronic phase chronic myeloid leukemia:
i) ADULT and CHILD: Philadelphia positive (Ph+) Hepatic or severe renal impairment. History of
400 mg once daily. Accelerated phase or blast crisis Myelosuppression, gastrointestinal disturbances, Alfuzosin, aprepitant, carbamazepine,
chronic myeloid leukaemia in chronic phase and in cardiac disease. Severe fluid retention may occur. It
chronic myeloid leukemia: 600 mg once daily. CHILD eczema, rash, myalgia, arthralgia, fluid retention, dexamethasone, ketoconazole, levothyroxine,
early acceleration after failure of interferon therapy ii) is recommended that patients be weighed regularly. Hypersensitivity to imatinib or any component of
Imatinib Mesylate 400 mg Tablet Glivec more than 2 years, chronic myeloid leukemia: 340 pneumonia, cardiac failure and hepatic failure, phenobarbital, phenytoin, rifampin, simvastatin,
Treatment of patients with unresectable and or Regular monitoring of complete blood counts and the product. Avoid pregnancy and lactation
mg/m2 daily. Max: 60 mg/day ii) Unresectable and or gynaecomastia (due to reduced testosterone), St John's Wort, warfarin, ciclosporin and
metastatic, malignant gastrointestinal stromal tumours liver function tests. Children less than 3 year.
metastatic, malignant gastrointestinal stromal tumours vomiting, nausea paracetamol
(GIST) who are positive for CD117/c-kit Pregnancy, lactation (avoid)
GIST: 400 mg/day
Based on type or severity of infection, susceptibility of Hypersensitivity to penicillins, cephalosporins and
Thrombophlebitis, pain, erythema & tenderness
pathogen(s) and patient condition including body weight other beta lactams. History of GI disease. Caution in
following injection. Rash, urticaria, pruritus, GI
and renal function. ADULT: 1 - 2 g/day in 3 - 4 divided patients with CNS disorders and or compromised
Severe infections caused by susceptible pathogens disturbances, pseudomembranous colitis, Hypersensitivity to local anaesthetics of the
Imipenem 500 mg and Cilastatin 500 doses. Maximum: 4 g/day or 50 mg/kg/day. Infusion renal function in whom accumulation of drug could
Tienam especially useful in infections involving ESBL haematological disturbances, increase in liver amide-type and in patients with severe shock or Ganciclovir
mg Injection rate: less than 500 mg dose: over 20 - 30 minutes, occur. If CNS symptoms occur, dosage should be
organisms. Not to be used for prophylaxis enzymes, taste perversion. Myoclonic activity, heart block
more than 500 mg: dose over 40 - 60 minutes. CHILD: decreased or discontinued. Usage during
seizures, psychic disturbances, confusional
15 - 30 mg/kg/dose, infusion at 6 - 12 hourly intervals pregnancy, lactation and children less than 3 months
states
depending on age. Maximum: 2 g/day or paediatrics patients with impaired renal function
Initially up to 75 mg daily in divided doses increased MAOIs use within 14 days, first trimester of Barbiturates, alcohol, tranquilliser,
Anticholinergic, drowsiness, dizziness, tinitus,
gradually to 150 - 200 mg (up to 300 mg in hospital Patient with thrombosis, angina, congestive heart pregnancy, hypersensitivity to imipramine anticholinergics, class Ia and III antiarrhythmics,
palpitation and tachycardia, seizure, weight gain,
patients); up to 150 mg may be given as a single dose failure, urinary retention, glaucoma and agitated products, during acute recovery phase of beta 2 agonists, carbamazepine, cimetidine,
Imipramine HCI 25 mg Tablet Tofranil Depression constipation, urinary retention, increased
at bedtime. ELDERLY initially 10 mg daily; increased patient, seizure, thyroid disease, impaired liver myocardial infarction, arrhythmias (particularly lithium, quinolones, indirect/mixed
appetite, confusion, agranulocytosis,
gradually to 30 - 50 mg daily; CHILD is not function, lactation heart block), not indicated in manic phase, sympathomimetics, fluoxetine, clonidine, CNS
thrombocytopenia, blood dyscrasias
recommended severe liver disease antidepressants
Autoimmune conditions, pre-existing; use with
caution, drug treatment to affected area; hold
therapy until completely healed, inflammatory
conditions of the skin, including chronic graft versus
host disease; may be exacerbated by imiquimod,
local inflammatory reaction due to imiquimod
therapy; if severe local or systemic flu-like signs and
Treatment of external genital and perianal warts or Apply to affected area at bedtime for 3 times a week for symptoms occur, discontinue imiquimod therapy Erythema, erosion, excoriation/flaking, oedema,
Imiquimod 5 % w/w Cream Aldara Hypersensitivity to imiquimod products Not known
condyloma acuminata in adults up to 16 weeks; leave on skin for 6-10 hours temporarily until completely healed, sunlight induration, scabbing, vesicles
exposure, including sunlamps; use methods to
protect skin from sunlight exposure to prevent
serious sunburns; if sunburn occurs hold imiquimod
therapy until completely healed, surgical treatment to
affected area; hold therapy until completely healed,
superficial basal cell carcinoma; confirm diagnosis
before treatment, avoid contact with eyes
i) Post-exposure prophylaxis (PEP) among healthcare
ADULT: 800 mg every 8 hours. CHILD (investigational):
workers in high-risk HIV occupational exposure ii) For Nephrolithiasis, acute haemolytic anaemia, Ketoconazole, rifampicin, cisapride, astemizole,
500 mg/m2 every 8 hours (patients with smaller body Asthenia/fatigue, abdominal pain, dry mouth, Breast feeding, known hypersensitivity to this
Indinavir Sulfate 400 mg Capsule Crixivan therapy as part of combination antiretroviral treatment hyperglycaemia, pregnancy, lactation, phenobarbitone, phenytoin, carbamazepine,
surface area (BSA) may require lower doses of 300 - flatulence, lymphadenopathy compound
on adult HIV patients ie Highly Active Anti-Retroviral hyperlipidaemia dexamethasone, sildenafil, St. John's Wort
400 mg/m2 every 8 hours)
Therapy (HAART)
Hypersensitivity, rhinitis, urticaria, asthma, or
allergic reactions to aspirin or other anti- Salicylates, anticoagulant drugs, probenecid,
Suppository may cause tenesmus & irritation of Nausea, vomiting, anorexia, epigastric,
Indomethacin 100 mg Suppository Indocid Pain and inflammation in rheumatic arthritis 100 mg at night.Child not recommended inflammatory agents, use of suppository methotrexate, ciclosporin, lithium, diuretics,
rectal mucosa constipation, fatigue
contraindicated in patients with recent rectal digoxin, beta-blockers, captopril
bleeding or proctitis, pregnancy, lactation
Active or previous history of gastrointestinal Salicylates, anticoagulant drugs, probenecid,
Gastrointestinal disturbances and bleeding,
ulceration, bleeding, or perforation. History of methotrexate, ciclosporin, lithium, digoxin, beta-
headache, vertigo, depression, epigastric
renal/liver dysfunction. Hypertension or cardiac blockers, captopril, heparin or thrombolytic
disease, dizziness, somnolence, depression & Hypersensitivity, rhinitis, urticaria, asthma or
conditions aggravated by fluid retention and agents, aminoglycosides, digitalis glycosides.
50 - 200 mg daily in divided doses, with food. Child not fatigue, anxiety, psychic disturbances including allergic reactions to aspirin or other anti-
Indomethacin 25 mg Capsule Indocid Pain and inflammation in rheumatic disease oedema. May aggravate depression/psychiatric antihypertensives, diuretics especially
recommended. psychotic episodes, mental confusion, tinnitus, inflammatory agents, proctitis, pregnancy &
disorders such as epilepsy, mental depression, triamterene, diflunisal, other salicylates,
corneal deposits, retinal disturbances, oedema, lactation
Parkinsonism. Patients with coagulation defects. cefamandole, cefoperazone, cefotetan,
weight gain, flushing, sweating,
Renal impairment. Retinal disturbances. Elderly. plicamycin, valproic acid, gold compound, other
thrombocytopenia, rash, pruritus & urticaria
Pregnancy and lactation nephrotoxics & zidovudine
i) Rheumatoid arthritis: ADULT over 18 years old: 3
Discontinue use if severe infections develop. Heart Influenza, herpes infections, serum-sickness-like
mg/kg at 0, 2, 6 weeks, then every 8 weeks; May
failure, history of recurrent infections, demyelinating reactions, headache, vertigo/dizziness, flushing,
increase to 10 mg/kg or increase dosing frequency to 4
i) Rheumatoid arthritis (moderate to severe), in disorders, risk of infections, acute suppurative upper and lower respiratory tract infections, Hypersensitivity, severe infections such as
weekly for patients with incomplete response.
combination with methotrexate ii) Ankylosing fistula. Patients undergoing surgery. Child and dyspnoea, sinusitis, gastrointestinal tuberculosis, sepsis, abscesses and Methotrexate and other immunomodulators,
Infliximab 100 mg Injection Remicade Discontinue if no response by 12 weeks of initial
spondylitis in patients with active disease despite elderly. Monitor for signs of infection for 6 month disturbances, rash, pruritus, urticaria, increased opportunistic infections, moderate or severe anakinra, vaccines
infusion or after dose adjustment ii) Ankylosing
treatment with methotrexate before, during and for 6 month after treatment. sweating, dry skin, fatigue, chest pain, infusion- heart failure, pregnancy and lactation
spondylitis: ADULT over 18 years: 5 mg/kg IV over 2
Monitor hepatic function. Avoid pregnancy/breast related reactions, fever, elevated hepatic
hour given at week 0, 2, and 6 then every 6-8 weeks.
feeding for at least 6 months after last treatment transaminases
Discontinue if no response by 6 weeks of initial infusion
Transient thrombocytopenia, transient
Influenza Vaccine (Inactivated, Serious acute febrile, bleeding disorders, on
lymphadenopathy, allergic reactions, neuralgia,
trivalent) Injection (containing 3 CHILD 6-35 months: Single dose of 0.5 ml IM or deep anticoagulant therapy, active neurologic disorder, Hypersensitivity to any components of the
Prophylaxis of influenza for frontliners (KKM staff and paraesthesia, febrile convulsions, neurological
strains, two type A subtypes, of which SC; 3-8 years: 1-2 doses of 0.5 ml IM ADULT & CHILD patients known to have experienced Guillain-Barré vaccine, eggs, chicken proteins, neomycin, Immunosuppressive drugs
essential services personnel) and in high risk groups disorders (such as encephalomyelitis, Guillain-
one must include pandemic A (H1N1) more than 9 years: Single dose of 0.5 ml IM syndrome within 6 to 8 weeks after a previous formaldehyde and octocinol 9
Barré Syndrome), vasculitis, generalized skin
and one Type B subtype) influenza vaccination
reactions
Oral hypoglycaemic agents, ocreotide, MAOIs,
alcohol, lithium, non selective beta blocker, ACE
Decreased insulin requirements due to hepatic or inhibitor, salicylates, anabolic steroids,
renal impairment, malabsorption, diarrhoea, Transient oedema, local reactions and fat glucocorticoids, oral contraceptives,
Diabetic Type 1 and 2 in patients that still experienced Dose to be individualised. The average daily insulin Hypersensitivity to insulin aspart and its
Insulin Aspart 100 IU/ml Injection Novorapid nausea/vomiting, hypothyroidism hypokalaemia, hypertrophy at injection site, hypoglycaemia, sulphonamides, disopyramides, diuretics
hypoglycaemia with use of human insulin requirement is between 0.5 to 1.0 units/kg body weight components, hypoglycaemia
stress due to fever, infection, surgery, trauma, hypokalaemia, generalized hypersensitivity fibrates, fluoxetine, propoxyphene, thyroid
systemic allergic reactions hormone, symphatomimetics, danazol, niacin,
isonazide, guanethidine, reserpine, clonidine,
phenothiazine
Decreased insulin requirements due to hepatic or Oral hypoglycaemic agents, octreotide, MAOIs,
renal impairment, malabsorption, diarrhoea, Hypoglycaemia, lipodystrophy, cutaneous beta blockers, ACE inhibitors, salicylates,
Insulin Aspart 30% and Protaminated Diabetic type 1 and 2 in patients that still experienced Dose to be individualised. The average daily insulin Hypersensitivity to insulin aspart and its
Novomix nausea/vomiting, hypothyroidism, hypokalaemia, hypersensitivity, injection site reaction , diabetic alcohol, anabolic steroids, sulphonamides, oral
Insulin Aspart 70% 100 U/ml Injection hypoglycaemia with use of human insulin requirement is between 0.5 to 1.0 units/kg body weight components, hypoglycaemia
stress due to fever, infection, surgery, trauma, ketoacidosis, hypoglycaemia contraceptives, thiazides, glucocorticoids, thyroid
systemic allergic reactions hormones, sympathomimetics, danazol
ACE inhibitors, aspirin, beta- blockers, fibrates,

Insulin dose adjustment may be needed with renal or
Severe hypoglycemic episodes, lipodystrophy, fluoxetine, fenfluramine, fluoroquinolones,
i) Diabetes mellitus type I in adults and child over 6 ADULT and CHILD over 6 years: individualised dose hepatic impairment, illness, stress, emotional
Insulin Glargine 300 IU/3ml Injection Lantus rash, diabetic ketoacidosis, allergic skin Hypersensitivity, intravenous administration ginseng, MAOIs, oestrogen and progestogens,
years ii) Diabetes mellitus type II in adult given by SC, once daily at the same time every day disturbances or in elderly patients, may impair ability
reactions somatropin, lithium, clonidine, sulphonamide
to drive and operate machinery
antibiotic, pentoxifylline
Insulin dependent diabetes mellitus, non insulin

Insulin Recombinant Neutral Human dependent diabetes unresponsive to treatment to diet MAOIs, alcohol, corticosteroid, oral
Dose to be individualised. The average daily insulin
short-acting 100 IU/ml Injection in Actrapid/Humulin or oral hypoglycaemics. hyperkalaemia to assure Psychic stress, infection, pregnancy Rare incidence of allergy and lipoatrophy Hypoglyacemia, insulinoma contraceptives, beta-blocker, thyroid hormone,
requirement is between 0.5-1.0 units/kg body weight
10ml vial proper utilisation of glucose and reduce glucosuria in diuretic
non diabetic patients receiving parenteral nutrition

Insulin Recombinant Synthetic dependent diabetes unresponsive to treatment to diet MAOIs, alcohol, corticosteroid, oral
Human, intermediate-acting 100 IU/ml Humilin/Insulatard or oral hypoglycaemics, hyperkalaemia, to assure Psychic stress, infection, pregnancy Rare incidence of allergy and lipoatrophy Hypoglyacemia, insulinoma contraceptives, beta-blocker, thyroid hormone,
Injection in 10ml vial proper utilisation of glucose and reduce glucosuria in diuretic

Human, intermediate-acting 100 IU/ml Insulatard or oral hypoglycaemics, hyperkalaemia to assure Psychic stress, infection, pregnancy Rare incidence of allergy and lipoatrophy Hypoglyacemia, insulinoma contraceptives, beta-blocker, thyroid hormone,
Penfill and Refill proper utilisation of glucose and reduce glucosuria in diuretic

Human, pre-mixed 100 IU/ml Injection Mixtard or oral hypoglycaemics, hyperkalaemia, to assure Psychic stress, infection, pregnancy Rare incidence of allergy and lipoatrophy Hypoglyacemia, insulinoma contraceptives, beta- blocker, thyroid hormone,
in 10ml vial proper utilisation of glucose and reduce glucosuria in diuretic

Human, pre-mixed 100 IU/ml Penfill Mixtard or oral hypoglycaemics, hyperkalaemia to assure Psychic stress, infection, pregnancy Rare incidence of allergy and lipoatrophy Hypoglyacemia, insulinoma contraceptives, beta- blocker, thyroid hormone,
and Refill proper utilisation of glucose and reduce glucosuria in diuretic

Human, short-acting 100 IU/ml Penfill Actrapid or oral hypoglycaemics, hyperkalaemia to assure Psychic stress, infection, pregnancy Rare incidence of allergy and lipoatrophy Hypoglyacemia, insulinoma contraceptives, beta-blocker, thyroid hormone,
and Refill proper utilisation of glucose and reduce glucosuria in diuretic
i) 2 MIU SC or IM 3 times a week ii) Patient more than

18 years: 3 - 9 MIU 3 - 5 times a week or daily Pregnancy, lactation, cardiovascular disease,
depending on response iii) Patient more than 18 years. patients with severe renal or hepatic impairment, Nausea, vomiting, flu-like symptoms, lethargy,
Initially escalating dose to 18-36 MIU SC/IM for 10-12 cardiac and coagulation disorders, depression or ocular side effects, bone marrow depression and
For the treatment of i) Hairy cell leukaemia ii) Chronic
weeks. Maintenance: up to 36 MIU 3 times weekly iv) psychiatric disorders, epilepsy or other central other central nervous system effects, anorexia,
Interferon Alfa-2b 18 MIU Multidose myelogenous leukaemia iii) AIDS related Kaposi's Decompensated hepatic disease, Inhibit metabolism of theophylline, ACE
Intron-A 2.5-5 MIU/m2 SC 3 times weekly for 4-6 month. CHILD: nervous system diseases, pulmonary and hypotension, hypertension, arrhythmias, rash,
Injection Pen sarcoma iv) Chronic hepatitis B v) Chronic hepatitis C immunosuppressed transplant inhibitors, colchicine, warfarin
up to 10 MIU/m2 BSA v) 3 MIU for 12 months vi) As an autoimmune diseases, diabetes mellitus, alopecia, diarrhoea, diaphoresis, change in
vi) Advanced renal cell carcinoma
adjunct to cytotoxic chemotherapy: An escalating dose myelosuppression, poorly controlled thyroid function. taste. SC: Injection site pain. Nasal: Mucosal
of 3 million IU 3 times/week for 1 week, then 9 million IU May affect the ability to drive or operate machinery. irritation and damage
3 times/week for 1 week, then 18 million IU 3 Monitor blood counts, hepatic and renal function
times/week thereafter for 3-12 month SC or IM
18 years: 3 - 9 MIU 3 - 5 times a week or daily Pregnancy, lactation, cardiovascular disease,
depending on response iii) Patient more than 18 years. patients with severe renal or hepatic impairment, Nausea, vomiting, flu-like symptoms, lethargy,
Initially escalating dose to 18-36 MIU SC/IM for 10-12 cardiac and coagulation disorders, depression or ocular side effects, bone marrow depression and
For the treatment of i) Hairy cell leukaemia ii) Chronic
weeks. Maintenance: up to 36 MIU 3 times weekly iv) psychiatric disorders, epilepsy or other central other central nervous system effects, anorexia,
Interferon Alfa-2b 30 MIU Multidose myelogenous leukaemia iii) AIDS related Kaposi's Decompensated hepatic disease, Inhibit metabolism of theophylline, ACE
Intron-A 2.5-5 MIU/m2 SC 3 times weekly for 4-6 month. CHILD: nervous system diseases, pulmonary and hypotension, hypertension, arrhythmias, rash,
Injection Pen sarcoma iv) Chronic hepatitis B v) Chronic hepatitis C immunosuppressed transplant inhibitors, colchicine, warfarin
up to 10 MIU/m2 BSA v) 3 MIU for 12 months vi) As an autoimmune diseases, diabetes mellitus, alopecia, diarrhoea, diaphoresis, change in
vi) Advanced renal cell carcinoma
adjunct to cytotoxic chemotherapy: An escalating dose myelosuppression, poorly controlled thyroid function. taste. SC: Injection site pain. Nasal: Mucosal
of 3 million IU 3 times/week for 1 week, then 9 million IU May affect the ability to drive or operate machinery. irritation and damage
i) 2 MIU SC or IM 3 times a week ii) Patient more than Pregnancy, lactation, severe myelosuppression.
18 years: 3 - 9 MIU 3 - 5 times a week or daily Cardiac disease, renal and hepatic impairment,
depending on response iii) Patient more than 18 years. history of seizures, central nervous system Nausea, vomiting, flu-like symptoms, lethargy,
Decompensated hepatic disease,
Initially escalating dose to 18-36 MIU SC/IM for 10-12 disorders, myelosuppressive disorders, depression ocular side effects, bone marrow depression and
For the treatment of i) Hairy cell leukaemia ii) Chronic immunosuppressed transplant. Hypersensitivity.
weeks. Maintenance: up to 36 MIU 3 times weekly iv) or psychosis, poorly controlled thyroid dysfunction, other central nervous system effects, anorexia,
myelogenous leukaemia iii) AIDS related Kaposi's Pregnancy and lactation. Autoimmune diseases, Inhibit metabolism of theophylline, ACE
Interferon Alpha - 2a 3 MIU Injection Roferon-A 2.5-5 MIU/m2 SC 3 times weekly for 4-6 month. CHILD: pulmonary disease, diabetes mellitus, coagulation hypotension, hypertension, arrhythmias, rash,
Sarcoma iv) Chronic hepatitis B v) Chronic hepatitis C visceral AIDS-related Kaposi's sarcoma inhibitors, colchicine, warfarin
up to 10 MIU/m2 BSA v) 3 MIU for 12 months vi) As an disorders, psoriasis. Monitor blood counts and alopecia, diarrhoea, diaphoresis, change in
vi) Advanced renal cell carcinoma associated with rapidly progressing or life-
adjunct to cytotoxic chemotherapy: An escalating dose serum chemistry in patients at high risk of taste, thyroid dysfunction. SC: Inj site pain.
threatening disease
of 3 million IU 3 times/week for 1 week, then 9 million IU myelosuppression. Monitor hepatic, renal and Nasal: Mucosal irritation and damage
3 times/week for 1 week, then 18 million IU 3 cardiac function. Maintain adequate hydration.
times/week thereafter for 3-12 month SC or IM Driving or operating machinery may be impaired
i) 2 MIU SC or IM 3 times a week ii) Patient more than Pregnancy, lactation, severe myelosuppression.
18 years: 3 - 9 MIU 3 - 5 times a week or daily Cardiac disease, renal and hepatic impairment,
depending on response iii) Patient more than 18 years. history of seizures, central nervous system Nausea, vomiting, flu-like symptoms, lethargy,
Initially escalating dose to 18-36 MIU SC/IM for 10-12 disorders, myelosuppressive disorders, depression ocular side effects, bone marrow depression and
For the treatment of i) Hairy cell leukaemia ii) Chronic immunosuppressed transplant. Hypersensitivity.
weeks. Maintenance: up to 36 MIU 3 times weekly iv) or psychosis, poorly controlled thyroid dysfunction, other central nervous system effects, anorexia,
myelogenous leukaemia iii) AIDS related Kaposi's Pregnancy and lactation. Autoimmune diseases, Inhibit metabolism of theophylline, ACE
Interferon Alpha - 2a 4.5 MIU Injection Roferon-A 2.5-5 MIU/m2 SC 3 times weekly for 4-6 month. CHILD: pulmonary disease, diabetes mellitus, coagulation hypotension, hypertension, arrhythmias, rash,
Sarcoma iv) Chronic hepatitis B v) Chronic hepatitis C visceral AIDS-related Kaposi's sarcoma inhibitors, colchicine, warfarin
up to 10 MIU/m2 BSA v) 3 MIU for 12 months vi) As an disorders, psoriasis. Monitor blood counts and alopecia, diarrhoea, diaphoresis, change in
adjunct to cytotoxic chemotherapy: An escalating dose serum chemistry in patients at high risk of taste, thyroid dysfunction. SC: Inj site pain.
threatening disease
of 3 million IU 3 times/week for 1 week, then 9 million IU myelosuppression. Monitor hepatic, renal and Nasal: Mucosal irritation and damage
3 times/week for 1 week, then 18 million IU 3 cardiac function. Maintain adequate hydration.
times/week thereafter for 3-12 month SC or IM Driving or operating machinery may be impaired
18 years: 3 - 9 MIU 3 - 5 times a week or daily Pregnancy, lactation, severe myelosuppression,
depending on response iii) Patient more than 18 years. cardiovascular disease, patients with severe renal or Nausea, vomiting, flu-like symptoms, lethargy,
Initially escalating dose to 18-36 MIU SC/IM for 10-12 hepatic impairment, cardiac and coagulation ocular side effects, bone marrow depression and
For the treatment of i) Hairy cell leukaemia ii) Chronic immunosuppressed transplant, hypersensitivity.
weeks. Maintenance: up to 36 MIU 3 times weekly iv) disorders, depression or psychiatric disorders, other central nervous system effects, anorexia,
myelogenous leukaemia iii) AIDS related Kaposi's Pregnancy and lactation. Autoimmune diseases,
Interferon Alpha 2b 3 MIU Injection Intron-A 2.5-5 MIU/m2 SC 3 times weekly for 4-6 month. CHILD: epilepsy or other central system diseases, arrhythmias, rash, alopecia, diarrhoea, Inhibit metabolism of theophylline
Sarcoma iv) Chronic Hepatitis B v) Chronic Hepatitis C visceral AIDS-related Kaposi's sarcoma
up to 10 MIU/m2 BSA v) 3 MIU for 12 months vi) As an pulmonary and autoimmune diseases, diabetes diaphoresis, change in taste, thyroid dysfunction.
adjunct to cytotoxic chemotherapy: An escalating dose mellitus, poorly controlled thyroid function. May SC: Injection site pain. Nasal: Mucosal irritation
threatening disease
of 3 million IU 3 times/week for 1 week, then 9 million IU affect the ability to drive or operate machinery. and damage
i)Relapsing-remitting multiple sclerosis (RRMS):
Reduction of frequency and degree of severity of Injection site reactions, flu-like symptoms
clinical relapses in ambulatory patients characterized History of seizures, depression, pre-existing heart (decreases over time). Menstrual disorders, CNS
Pregnancy, lactation. Children less than 18 year.
by at least two attacks of neurological dysfunction over disorders, bone marrow disorder, anaemia or a low effects, muscle stiffness, haematological
Interferon beta -1b 250mcg (8MIU) History of severe depressive illness and or Immune-modulating drugs, other drugs
Betaferon the preceding two year period, followed by complete or 0.25 mg (8 MIU) by SC injection every other day platelet level. Fever or infection. Renal insufficiency. changes, occasional nausea and vomiting.
Injection suicidal thoughts, liver failure or inadequately metabolised by cytochrome P450 system
incomplete recovery ii)Secondary progressive multiple Discontinue therapy until healing from multiple Rarely, alopecia, serious hypersensitivity
treated epilepsy
sclerosis (SPMS):Reduction of frequency and severity lesions has taken place. Monoclonal gammopathy reactions, cardiomyopathy, thyroid gland
of clinical relapses and for slowing the progression of dysfunction
disease
Angina, chronic heart failure or arrhythmia, severe
renal and hepatic failure, severe myelosuppression,
Hypersensitivity, severe renal and liver failure,
depression. Monitor serum ALT levels at baseline,
Irritation at injection site. Headache, fatigue, children less than 6 years, pregnancy, lactation,
month 1, 3 and 6 of therapy and periodically
Multiple sclerosis of the relapsing remitting type with 2 fever, pain, chills, depression, dizziness, nausea, psychiatric disorders, severe depressive ACE inhibitors, warfarin, zidovudine,
Interferon Beta-1a 22 mcg Rebif 22 mcg 3 times weekly thereafter in the absence of clinical symptoms.
or more relapses within the last 2 years abdominal pain, urinary tract infection, disorders and or suicidal ideation. Epileptic antiepileptics, antidepressant
Monitor full blood count (FBC) with differential and
leucopenia patients with a history of seizures not adequately
platelet count. Preexisting seizure disorders. Thyroid
controlled by treatment
function testing is recommended at baseline and if
abnormal, 6-12 monthly following initiation of therapy
Angina, chronic heart failure or arrhythmia, severe

renal and hepatic failure, severe myelosuppression,
Hypersensitivity, severe renal and liver failure,
depression. Monitor serum ALT levels at baseline,
Irritation at injection site. Headache, fatigue, children less than 6 years, pregnancy, lactation,
month 1, 3 and 6 of therapy and periodically
Multiple sclerosis of the relapsing remitting type with 2 fever, pain, chills, depression, dizziness, nausea, psychiatric disorders, severe depressive ACE inhibitors, warfarin, zidovudine,
Interferon Beta-1a 44 mcg Rebif 44 mcg 3 times weekly thereafter in the absence of clinical symptoms.
or more relapses within the last 2 years abdominal pain, urinary tract infection, disorders and or suicidal ideation. Epileptic antiepileptics, antidepressant
Monitor full blood count (FBC) with differential and
leucopenia patients with a history of seizures not adequately
platelet count. Preexisting seizure disorders. Thyroid
controlled by treatment
function testing is recommended at baseline and if
abnormal, 6-12 monthly following initiation of therapy
Warm sensation, hypertension, hypotension,
nausea, vomiting,taste changes, bradycardia,
chest pain, tachycardia, venospasm, syncope,
shock, thrombophlebitis, dyspnea, agitation,
confusion, and cyanosis progressing to
Multiple myeloma, known or suspected unconsciousness may occur, cardiac arrest,
pheochromocytoma should use the lowest possible ventricular fibrillation, cardiac arrythmia, pruritus,
dose; blood pressure should be monitored urticaria, pallor, rash, fever, facial or conjunctival
throughout the procedure, severely debilitated and petechiae, hematomas, red blood cell clumping
marked hypertension, severe concomitant hepatic and agglutination, crenation, neutropenia,
Iodamide Injection Isteropac For hysterosalpingography According to the procedure and route of administration Hypersensitivity to iodamide products Metformin
and renal disease or anuria, dehydration, sickle cell muscle-cramps, allergic-like reaction, which may
disease, hypersensitivity iodine products, possibility range in severity from rhinitis or angioneurotic
of thrombosis or other complications due to the edema to laryngeal or bronchial spasm, and
mechanical trauma of the procedure hyperthyroidism rarely anaphylactoid shock, headache, fatigue,
or with an autonomously functioning thyroid nodule malaise, tremors, anxiety, numbness of head
and neck, convulsions, lacrimation, proteinuria,
temporary renal shutdown, coughing, wheezing,
nasal congestion, laryngeal or pulmonary
oedema, shortness of breath and asthmatic
reaction
Concomitant use with lithium may result in
i) Pre-operative treatment of thyrotoxicosis ii) Should not be used for long term treatment.
Iodine and Potassium Iodide Solution Lugol's Solution i) 1 ml daily in divided doses ii) 2 - 3 ml daily Hypersensitivity reactions, headache, lacrimation Breast feeding hypothyroidism and decrease the effects of oral
Thyrotoxicosis crisis Pregnancy, lactation, children
anticoagulants
Hypersensitivity to other iodinated contrast media, Nausea, vomiting, skin rash and pruritus
X-ray contrast medium for cardioangiography, cerebral history of allergies or allergic reactions to other depending on type of examination, cortical Manifest thyrotoxicosis, hypersensitivity, Metformin; injection of iodinated contrast
angiography, peripheral arteriography, abdominal medications, renal insufficiency, congestive heart blindness, heat sensation, abdominal, intrathecal administration may cause materials in metformin-treated patients has been
Iodixanol 320 mg I/ml Injection Visipaque angiography, uroloraphy, venography, CT Depending on type of examination failure, history of thromboembolic disorders, multiple discomfort, hypersensitivity reaction, death,concurrent use of metformin is associated with lactic acidosis and can lead to
enhancement, lumbar, thoracic and cervical myeloma, hyperthyroidism, pheochromocytoma, arrhythmias, hypertension, ischemia, vasovagal contraindicated in patients receiving acute renal failure. False-positive results for
myelography patients should be well-hydrated prior to iodixanol reactions, chest pain, injection site pain, altered intravascular iodinated contrast media protein in urine when measured with Multistix(R)
administration to minimize adverse renal effects or bad taste, paresthesias, nephrotoxicity
Patients should be well hydrated prior to and Nausea, vomiting, thromboembolism, injection
following iohexol administration, previous reaction to site pain, headache, altered taste, general
a contrast medium, sensitivity to iodine, asthma, hay feeling of warmth, flushing, weakness, dizziness,
fever, food allergy. Meticulous angiographic coughing, rhinitis, sweating, sneezing,
X-ray contrast medium for use in adults and children for
techniques are recommended, including close lacrimation, visual disturbances, pruritus, salivary
cardioangiography, arteriography, urography,
attention to guidewire and catheter manipulation, use gland enlargement, pallor, cardiac disorders,
phlebography and CT-enhancement. Lumbar, thoracic,
of manifold systems and/or 3-way stopcocks, haemodynamic disturbances and hypotension, Manifest thyrotoxicosis. History of serious Locetamic acid, iopanoic acid, ipodate,
cervical myelography and computed tomography of the
Iohexol Injection Omnipaque Dose depending on the route and procedure frequent catheter flushing with heparinized solutions, nephrotoxicity. Rarely, convulsions, paralysis, reaction to iohexol and hypersensitivity to iodine- metformin, tyropanoate sodium, interleukin-2,
basal cisterns, following subarachnoid injection.
and minimizing the length of the procedure, severe coma, rigors, arrhythmias, pulmonary oedema, containing compounds amiodarone
Arthrography, endoscopic retrograde pancreatography
hepatic impairment, renal impairment, dehydration - circulatory failure and cardiac arrest;
(ERCP), herniography, hysterosalpingography,
correct fluid and electrolyte balance before occasionally anaphylactoid or hypersensitivity
sialography and studies of the gastrointestinal tract
administration; multiple myeloma, cardiac disease, reactions, hyperthyroidism; pain on injection;
hypertension, phaeochromocytoma, sickle-cell extravasation may result in tissue damage,
disease, hyperthyroidism, elderly and debilitated or thrombophlebitis, thrombosis, venospasm and
children, pregnancy, lactation embolism
i) Neuroradiology : myeloradiculography,
Pulmonary hypertension, cerebral venous
cisternography and ventriculography ii) Angiograph : Asthma, history of allergy, severe hepatic and renal
thrombosis, coagulation abnormalities,
cerebral arteriography, thoracic aortography, impairment, dehydrated patient, severe
hypotension, nausea, vomiting, neurological
abdominal aortography, angiocardiography, selective For angiography and cardiac cases- dose depending hypertension, advanced cardiac disease, There are no definite or absolute
sequelae to lumbar myelography, myocardial
visceral arteriography, peripheral arteriography, on the route and procedure. For selected vascular phaeochromocytoma, sickle-cell disease, contraindications, with the possible exception of
Iopamidol Injection Iopamiro infarction, stroke, ventricular arrhythmias, Metformin
venography, digital subtraction angiography (DSA), examination - bottles of 30 ml and 100 ml; dose hyperthyroidism, very old and very young patient, Waldenstrom's macroglobulinaemia, multiple
bradycardia and transient ischemic attacks,
DSA of cerebral arteries, DSA of peripheral arteries, depending on the route and procedure multiple myeloma or other paraproteinemia, myeloma and severe liver and kidney diseases
hives, skin rash, urticaria, pruritus, severe
DSA of abdominal arteries iii) Urography : intravenous homozygous sickle cell disease, known sensitivity to
thrombocytopenia, deep venous thrombosis,
urography iv) Contrast enhancement in CT Scanning, iodine
dizziness, neurobahavioral reactions, headache
arthrography, fistulography
Patients should be well hydrated prior to and
following iopromide administration, previous reaction
to a contrast medium, sensitivity to iodine, asthma,
hay fever, food allergy. Caution in patients with renal Vasodilation, chest pain, hypertension, injection
Hypersensitivity to iopromide, iodine, or any
i) For angiography, urography, aortography and the dysfunction, combined renal and hepatic disease, site pain, headache, nausea, vomiting, urinary
component of the formulation; intrathecal use. In
visualization of body cavities ii) Contrast enhancement combined renal and cardiac disease, dehydration, urgency, back pain, cardiac arrest and rarely
Iopromide 300mg/50ml Injection Ultravist Dose depending on the route and procedure paediatrics : additional contraindication of Interleukins, metformin
during computerized tomography iii) To check diabetes mellitus, sickle-cell disease, severe hypotension or shock, injection site pain,
prolonged fasting and laxative use prior to
functioning of a dialysis shunt thyrotoxicosis, myelomatosis or anuria, allergic urticaria, angiodema, metallic taste, dizziness,
administration of iopromide
reactions, cardiovascular disease especially blurred vision, nephrotoxicity
congestive heart failure, extravasation,
hyperthyroidism, elderly patients, multiple myeloma,
pheochromocytoma
Large doses is irritant to whole gastrointestinal Avoid in shock, convulsion and cardiovascular
Ipecacuanha Pro Infant Mixture Ipecac As paediatric expectorant CHILD up to 1 year : 5 ml, 1 - 5 years : 10 ml Not known Not known
and can lead to vomiting and diarrhoea disease
Only for treatment of : i) Patients with ischaemic heart
disease who develop extrasystole with salbutamol or
Bronchodilatory effect intensified by beta-
terbutaline ii) Patients with chronic bronchitis who have ADULT : 500 mcg up to 4 times daily. CHILD 5 - 12 Headache, nausea, dry mouth, rare and
Ipratropium Bromide 0.0125% Narrow-angle glaucoma, prostatic hypertrophy, Hypersensitivity to ipratropium products, adrenergic and xanthine preparation.
Atrovent airway obstruction and who do not respond to years : 125 - 250 mcg up to 4 times daily, 12 years : reversible anticholinergic side effects, ocular side
Inhalation Solution (125 mcg/ml) cystic fibrosis, bladder-neck obstruction atropine, soya lecithin or related food products Anticholinergic effects of other drugs may be
salbutamol or terbutaline. Reversible airways 250 - 500 mcg up to 4 times daily effects if substances enters eyes, cough
enhanced. Cisapride - loss of cisapride efficacy
obstruction, particularly in chronic obstructive
pulmonary disease
Only for treatment of : i) Patients with ischaemic heart
disease who develop extrasystole with salbutamol or
Bronchodilatory effect intensified by beta-
terbutaline ii) Patients with chronic bronchitis who have ADULT : 500 mcg up to 4 times daily. CHILD 5 - 12 Headache, nausea, dry mouth, rare and
Ipratropium Bromide 0.025% Narrow-angle glaucoma, prostatic hypertrophy, Hypersensitivity to ipratropium products, adrenergic and xanthine preparation.
Atrovent airway obstruction and who do not respond to years : 125 - 250 mcg up to 4 times daily, 12 years : reversible anticholinergic side effects, ocular side
Inhalation Solution (250 mcg/ml) cystic fibrosis, bladder-neck obstruction atropine, soya lecithin or related food products Anticholinergic effects of other drugs may be
salbutamol or terbutaline. Reversible airways 250 - 500 mcg up to 4 times daily effects if substances enters eyes, cough
enhanced. Cisapride - loss of cisapride efficacy
obstruction, particularly in chronic obstructive
pulmonary disease
Patients predisposed to glaucoma, insufficiently
controlled diabetes mellitus, recent myocardial
Headache, dizziness, nervousness, tachycardia, Xanthine derivatives, other anticholinergics,
Acute attacks : 1 unit dose vial. In severe cases not infarction, severe organic heart or vascular
fine tremor, palpitations. Potentially serious Hypersensitivity to atropine or its derivatives or beta2-agonists, beta-blockers, tricyclic anti
Ipratropium Bromide 0.5 mg and Management of reversible bronchospasm associated relieved by 1 unit dose vial, 2 unit dose vials may disorders, hyperthyroidism, phaechromocytoma, risk
Combivent hypokalaemia may result from beta2-agonist to any other component. Hypertrophic depressants, MAOIs, glucocorticoids - increased
Salbutamol 2.5 mg per UDV with obstructive airway diseases require, patient should consult a doctor immediately. of narrow-angle glaucoma, prostatic hypertrophy or
therapy, dryness of mouth, dysphonia, ocular obstructive cardiomyopathy or tachyarrythmia risk of tachycardia, agitation, hypomania,
Maintenance : 1 unit dose vial 3 - 4 times daily bladder-neck obstruction, hypoxia, cystic fibrosis,
complications, allergic type reactions hypokalaemia
pregnancy and lactation, uriticaria, angioedema,
rash, broncospasm, oropharyngeal oedema
ADULT & CHILD more than 6 years; Acute asthma 2 Insufficiently controlled Diabetes Mellitus, recent
Fine tremor of skeletal muscles, nervousness,
Management of symptoms in chronic obstructive puffs. Severe cases: if breathing has not noticeably Myocardial Infarction, severe organic heart or Other beta-adrenergics and anticholinergics,
dry mouth, headache, dizziness, tachycardia and Hypertrophic obstructive cardiomyopathy,
Ipratropium Bromide 20 mcg and airway disorders with reversible bronchospasm such improved after 5 mins, 2 further puffs may be taken. vascular disorders, hyperthyroidism, xanthine derivatives, steroids, diuretics, digoxin,
Berodual® palpitations, hypokalaemia, cough, nausea, tachyarrhythmias. Hypersensitivity to atropine-
Fenoterol 50 mcg/dose Inhalation as bronchial asthma and chronic bronchitis with or Intermittent and long-term treatment 1-2 puffs for each phaeochromocytoma, prostatic hypertrophy, bladder- MAOI, tricyclic antidepressants, halogenated
vomiting, sweating, weakness, myalgia/muscle like substances & sympathomimetic amines
without emphysema administration, up to max 8 puffs/day (average: 1-2 neck obstruction, cystic fibrosis, predisposition to hydrocarbon anaesthesia
cramps
puffs three times daily) narrow-angle glaucoma. Pregnancy, lactation
Patients predisposed to glaucoma, insufficiently

controlled diabetes mellitus, recent myocardial
Headache, dizziness, nervousness, tachycardia, Xanthine derivatives, other anticholinergics,
infarction, severe organic heart or vascular
Ipratropium Bromide 20 mcg and ADULT and ELDERLY : 2 inhalations 4 times daily. fine tremor, palpitations. Potentially serious Hypersensitivity to atropine or its derivatives or beta2-agonists, beta-blockers, tricyclic anti
Management of reversible bronchospasm associated disorders, hyperthyroidism, phaechromocytoma, risk
Salbutamol base 100 mcg/dose Combivent Maximum : 12 inhalations daily. CHILD under 12 years hypokalaemia may result from beta2-agonist to any other component. Hypertrophic depressants, MAOIs, glucocorticoids : increased
with obstructive airway diseases of narrow-angle glaucoma, prostatic hypertrophy or
Inhalation not recommended therapy, dryness of mouth, dysphonia, ocular obstructive cardiomyopathy or tachyarrythmia risk of tachycardia, agitation, hypomania,
bladder-neck obstruction, hypoxia, cystic fibrosis,
complications, allergic type reactions hypokalaemia
pregnancy and lactation, urticaria, angioedema,
rash, broncospasm, oropharyngeal oedema
Only for treatment of : i) Patients with chronic bronchitis
20 - 40 mcg 3 - 4 times daily. In the early treatment, up Bronchodilatory effect intensified by beta-
who have airway obstruction and who do not respond Headache, nausea, dry mouth, rare and
Ipratropium Bromide 20 mcg/dose to 80 mcg 3 - 4 times daily. CHILD up to 6 years : 20 Narrow - angle glaucoma, prostatic hypertrophy, adrenergic and xanthine preparation.
Atrovent to Salbutamol or Terbutaline ii) Patients with ischaemic reversible anticholinergic side effects, ocular side Hypersensitivity to atropine and its derivatives
Inhalation mcg 3 times daily, 6 - 12 years : 20 - 40 mcg 3 times cystic fibrosis Anticholinergic effects of other drugs may be
heart disease who develop extrasystole with effects if substances enters eyes, cough
daily enhanced. Cisapride - loss of cisapride efficacy
Salbutamol or Terbutaline
Symptomatic hypotension including dizziness,
Lithium, potassium-sparing diuretics, potassium
Caution in aortic or mitral valve stenosis, obstructive hyperkalaemia, angioedema, nausea, vomiting,
Pregnancy (2nd and 3rd trimesters), lactation, supplements, central nervous system
hyperthrophic cardiomyopathy, renal artery stenosis. fatigue, musculoskeletal pain, diarrhoea,
Irbesartan 150 mg and Hypertension in patients who cannot tolerate ACE severe hepatic and renal impairment, refractory depressants, antidiabetic drugs, cholestyramine,
Co-approvel® 1 tablet daily Monitoring of plasma potassium concentration is dyspepsia, flushing, tachycardia, cough, sexual
Hydrochlorothiazide 12.5 mg Tablet inhibitors because of cough hypokalaemia, hypercalcaemia, biliary cirrhosis corticosteroids, ACTH, digitalis glycosides,
advised, particularly in elderly and patients with renal dysfunction, rash, urticaria, headache, myalgia,
and cholestatis NSAIDs, non-depolarising muscle relaxants,
impairment athralgia, tinnitus, taste disturbances, hepatitis
antigout medications and calcium salts
and renal dysfunction
Angioedema (present or past), lactation period,
excessive hypotension, hepatic or renal impairment, Diarrhoea, dyspepsia or heart burn, fatigue,
Hypertension, diabetic nephropathy (in patients who Potassium supplements, potassium sparing
Irbesartan 150 mg Tablet Aprovel 150 mg to 300 mg daily hyperkalaemia, hypertrophic cardiomyopathy, headache, upper respiratory tract infection, Hypersensitivity, pregnancy
cannot tolerate ACE inhibitors because of cough) diuretics, lithium, NSAIDs
stenosis, aortic or mitral valve stenosis, surgery or angioedema of the face, lips or throat
anaesthesia
Symptomatic hypotension including dizziness,
Lithium, potassium-sparing diuretics, potassium
Caution in aortic or mitral valve stenosis, obstructive hyperkalaemia, angioedema, nausea, vomiting,
Pregnancy (2nd and 3rd trimesters), lactation, supplements, central nervous system
hyperthrophic cardiomyopathy, renal artery stenosis. fatigue, musculoskeletal pain,diarrhoea,
Irbesartan 300 mg & Hypertension in patients who cannot tolerate ACE severe hepatic and renal impairment, refractory depressants, antidiabetic drugs, cholestyramine,
CoAprovel 1 tablet daily Monitoring of plasma potassium concentration is dyspepsia, flushing, tachycardia, cough, sexual
Hydrochlorothiazide 12.5 mg Tablet inhibitors because of cough hypokalaemia, hypercalcaemia, biliary cirrhosis corticosteroids, ACTH, digitalis glycosides,
advised, particularly in elderly and patients with renal dysfunction, rash, urticaria, headache, myalgia,
and cholestatis NSAIDs, non-depolarising muscle relaxants,
impairment athralgia, tinnitus, taste disturbances, hepatitis
antigout medications and calcium salts
and renal dysfunction
Angioedema (present or past), lactation period,
excessive hypotension, hepatic or renal impairment, Diarrhoea, dyspepsia or heart burn, fatigue,
Hypertension, diabetic nephropathy (in patients who Potassium supplements, potassium sparing
Irbesartan 300 mg Tablet Aprovel 150 mg to 300 mg daily hyperkalaemia, hypertrophic cardiomyopathy, headache, upper respiratory tract infection, Hypersensitivity, pregnancy
cannot tolerate ACE inhibitors because of cough) diuretics, lithium, NSAIDs
stenosis, aortic or mitral valve stenosis, surgery or angioedema of the face, lips or throat
anaesthesia
Diarrhoea (early or late) must be treated adequately

Only for patients with colorectal cancer who: i) have
In combination therapy (for previously untreated with delay of subsequent cycle until recovery. Increased risk of infection by the live vaccine,
relapsed within 6 months after the end of adjuvant
patients): 180 mg/m2 once every 2 weeks as an IV Antiemetic premedication is recommended. Avoid diuretics increase risks of dehydration secondary
chemotherapy with 5-fluorouracil-based regime ii) have Myelosuppression, diarrhoea (early or late), Hypersensitivity to irinotecan, pregnancy and
infusion over 90 mins followed by infusion with folinic extravasation. Caution with myelosuppression. to vomiting/diarrhea, prophylactic
Irinotecan HCl Trihydrate 100 mg/5ml progressive disease despite 5-fluorouracil nausea, vomiting, alopecia, dyspnoea, lactation, inflammatory bowel disease, bowel
Campto acid and 5-fluorouracil. In monotherapy (for previously Patients over 65 years old, patients who have dexamethasone as an antiemetic may enhance
Injection chemotherapy for advanced disease iii) good weakness, hypotension, acute renal failure, obstruction, plasma bilirubin concentration 1.5
treated patients): 350 mg/m2 administered as an previously received pelvic / abdominal radiation and lymphocytopenia, prochlorperazine may
performance status (WHO of 2 or less) The treatment colitis times the upper limit of reference range
intravenous infusion over 90 minutes period once every with poor performance status have increased risk of increase incidence of akathisia, antineoplastic
must be given in a tertiary oncology centre or have
3 weeks bone marrow suppression and diarrhoea, agents (myelosuppression and diarrhoea)
clearance in writing by an oncologist
neutopenia: may lead to sepsis and death
Diarrhoea (early or late) must be treated adequately
In combination therapy (for previously untreated with delay of subsequent cycle until recovery. Increased risk of infection by the live vaccine,
patients): 180 mg/m2 once every 2 weeks as an IV Antiemetic premedication is recommended. Avoid diuretics increase risks of dehydration secondary
chemotherapy with 5-fluorouracil-based regime ii) have Myelosuppression, diarrhoea (early or late), Hypersensitivity to irinotecan, pregnancy and
infusion over 90 mins followed by infusion with folinic extravasation. Caution with myelosuppression. to vomiting/diarrhea, prophylactic
Irinotecan HCl Trihydrate 40 mg/2 ml progressive disease despite 5-fluorouracil nausea, vomiting, alopecia, dyspnoea, lactation, inflammatory bowel disease, bowel
Campto acid and 5-fluorouracil. In monotherapy (for previously Patients over 65 years old, patients who have dexamethasone as an antiemetic may enhance
Injection chemotherapy for advanced disease iii) good weakness, hypotension, acute renal failure, obstruction, plasma bilirubin concentration 1.5
treated patients): 350 mg/m2 administered as an previously received pelvic / abdominal radiation and lymphocytopenia, prochlorperazine may
performance status (WHO of 2 or less) The treatment colitis times the upper limit of reference range
intravenous infusion over 90 minutes period once every with poor performance status have increased risk of increase incidence of akathisia, antineoplastic
3 weeks bone marrow suppression and diarrhoea, agents (myelosuppression and diarrhoea)
neutopenia: may lead to sepsis and death
Haemachromatosis, haemosiderosis, haemolytic
Anaphylactic reactions, chest pain, hypertension,
An initial test dose of 0.5 ml should be given over the Anaphylaxis has occurred with parenteral iron anaemia and all anaemias other than iron
urticaria, pruritus, rash, abdominal pain, nausea, Mycophenolate mofetil, decreased
desired route. For severe iron deficiency anaemia, 1-2 dextran. Patients with history of allergic disorders, deficiency anaemia, hypersensitivity to product
Iron Dextran 50 mg Fe/ml Injection Severe iron deficiency anaemia vomiting, diarrhoea, leucocytosis, arthralgias, mycophenolate mofetil efficacy.
ml daily given by deep IM. Dosage is individualized asthma, rheumatoid arthritis, inflammatory disorders or any of its components and parenteral
arthritis, convulsions, seizures, headache, Chloramphenicol, decreased iron effectiveness
according to total iron deficit such as lupus erythematosus preparation is not for subcutaneous
respiratory arrest, dyspnoea, haematuria
administration
Anaemia not due to iron deficiency, iron overload
Dialysis patients on erythropoietin therapy, second and Individualised dosage. ADULT and ELDERLY:
Anaphylactoid reactions, metallic taste, or disturbances in utilisation of iron, history of
third trimester pregnancy and post partum anaemia Cumulative dose is to be administered in single doses Avoid fast infusion as can cause hypotension, Doxycycline, levodopa, methyldopa,
headache, nausea, vomiting, hypotension, asthma, eczema or atopy, history of cirrhosis or
Iron Sucrose 100 mg/5 ml Injection Venofer patients with iron deficiency: i) who are not responsive of 100 - 200 mg of iron 2 - 3 times weekly depending on cardiovascular collapse. Do not administer mycophenolate mofetil, ofloxacin, omeprazole,
diarrhoea, leg cramp, loss of consciousness, hepatitis, serum transaminases 3 times the
to oral iron therapy ii) who may be at risk of allergic Hb level. By IV drip infusion, slow IV injection or directly concomitant with oral iron preparations penicillamine, tetracycline, zinc
seizure, dyspnoea upper limit, acute or chronic infection, chronic
reactions to iron dextran injection into the venous limb of the dialyser
alcoholism
Uterine curettage, raised intracranial pressure, Potentiates action of nondepolarising muscle
Cardio-respiratory depression, hepatic injury,
i) Induction- Initiate at a concentration of 0.5 % ii) cardiac, respiratory, renal or hepatic impairment. relaxants. Enhance effects of neuromuscular
hepatotoxicity, jaundice, malignant hyperthermia, Hypersensitivity to isoflurane, halogenated
Maintenance- 1 - 2.5 % in oxygen or nitrous oxide Elderly or obese patients. May impair ability to drive blockers, central nervous system depressants.
Isoflurane Liquid Forane i) Induction and ii) Maintenance of anaesthesia gastrointestinal upset, ileus, post-operation agents. Genetic susceptibility to malignant
mixture. 0.5 - 0.75 % with oxygen and nitrous oxide for or operate machinery. Avoid alcohol. Concomitant Enhanced hypotensive effects of ACE inhibitors,
shivering. Hypotension, arrhythmias, transient hyperthermia. Porphyria
Caesarian section use with adrenaline or other sympathomimetics. tricyclic antidepressants (TCAs), MAOIs,
rise in cerebrospinal fluid pressure
Pregnancy and lactation antihypertensives, antipsychotics, beta-blockers
Peripheral neuropathy and hepatotoxicity, Inhibits metabolism of antiepileptics
i) ADULT and CHILD 5 mg/kg (4-6 mg/kg) Increased risk of hepatitis in severe renal psychiatric sign or symptom, agranulocytosis, (carbamazepine, ethosuximide and phenytoin)
Isoniazid 100 mg Tablet - i) Tuberculosis ii)Tuberculous meningitis daily,maximum 300 mg daily) or 10 mg/kg 3 times dysfunction, chronic liver disease, daily users of anaemia, megaloblastic anaemia, Acute liver disease, hypersensitivity to isoniazid and diazepam, reduced plasma concentration of
weekly ii) 15 - 20 mg/kg daily alcohol, increased risk of fatal hepatitis in females thrombocytopenia, systemic lupus ketoconazole and increased theophylline plasma
erythematosus, seizure concentration
Peripheral neuropathy and hepatotoxicity, Inhibits metabolism of antiepileptics
i) ADULT and CHILD 5 mg/kg (4-6 mg/kg) Increased risk of hepatitis in severe renal psychiatric sign or symptom, agranulocytosis, (carbamazepine, ethosuximide and phenytoin)
Isoniazid 400 mg Tablet - i) Tuberculosis ii)Tuberculous meningitis daily,maximum 300 mg daily) or 10 mg/kg 3 times dysfunction, chronic liver disease, daily users of anaemia, megaloblastic anaemia, Acute liver disease, hypersensitivity to isoniazid and diazepam, reduced plasma concentration of
weekly ii) 15 - 20 mg/kg daily alcohol, increased risk of fatal hepatitis in females thrombocytopenia, systemic lupus ketoconazole and increased theophylline plasma
erythematosus, seizure concentration
CV disorders;toxic symptoms in patients with CV
If given as IM: Initially 0.2 mg (1 ml of 1:5000 solution), disorders may occur. Doses sufficient to increase
followed by 0.02-1 mg depending on clinical response. the heart rate more than 130 bpm may induce
Nervousness, dizziness, headache, tachycardia, Angina pectoris, cardiac arrhythmia associated
If given as SC: 0.2 mg (1 ml of 1:5000 solution), ventricular arrhythmias. Use with caution in patients
Complete heart block (third-degree artrioventricular palpitations, angina, Adams-Stokes attacks, with tachycardia, Digitalis-induced tachycardia or
followed by 0.15-0.2 mg depending on clinical with coronary artery disease, coronary insufficiency, Isoprenaline with adrenaline may produce
Isoprenaline HCl 0.2 mg/ml Injection Isuprel block) not responding to atropine, while waiting for pulmonary eodema, hypertension, hypotension, heart block. Hypersensitivity to isoproterenol or
response. If given as IV : 1-2 mg in 500 ml of dextrose diabetes, or hyperthyroidism, and in patients arrhythmias
cardiac pacing ventricular arrhythmias, tachyarrhythmias, other product ingredients and ventricular
5%, infused at a rate of 0.5-2 ml/min while the patient's sensitive to sympathomimetic amines. Elderly, labor
flushing and sweating arrhythmia requiring inotropic therapy
EKG is being monitored. The dose should be titrated to & delivery, cardiogenic shock,hypovolemia,
produce the desired clinical response refractory asthmatic children,elderly, children,
pregnancy
CV disorders;toxic symptoms in patients with CV
If given as IM: Initially 0.2 mg (1 ml of 1:5000 solution), disorders may occur. Doses sufficient to increase
followed by 0.02-1 mg depending on clinical response. the heart rate more than 130 bpm may induce
Nervousness, dizziness, headache, tachycardia, Angina pectoris, cardiac arrhythmia associated
If given as SC: 0.2 mg (1 ml of 1:5000 solution), ventricular arrhythmias. Use with caution in patients
Complete heart block (third-degree artrioventricular palpitations, angina, Adams-Stokes attacks, with tachycardia, digitalis-induced tachycardia or
followed by 0.15-0.2 mg depending on clinical with coronary artery disease, coronary insufficiency, Isoprenaline with adrenaline may produce
Isoprenaline HCl 1 mg/5 ml Injection Isuprel block) not responding to atropine, while waiting for pulmonary eodema, hypertension, hypotension, heart block. Hypersensitivity to isoproterenol or
response. If given as IV : 1-2 mg in 500 ml of dextrose diabetes, or hyperthyroidism, and in patients arrhythmias
cardiac pacing ventricular arrhythmias, tachyarrhythmias, other product ingredients and ventricular
5%, infused at a rate of 0.5-2 ml/min while the patient's sensitive to sympathomimetic amines. Elderly, labor
flushing and sweating arrhythmia requiring inotropic therapy
EKG is being monitored. The dose should be titrated to and delivery, cardiogenic shock,hypovolemia,
produce the desired clinical response refractory asthmatic children,elderly, children,
pregnancy
Acute myocardial infarction,cerebral
Hypotensive effects may be enhanced by
hemorrhage,congestive heart failure, glaucoma,
2-10 mg/hour IV infusion after dilution, higher doses up GI disturbances, headache, hypotension, Hypersensitivity to organic nitrates, anaemia, alcohol, beta-blocker, calcium channel blocker,
Isosorbide Dinitrate 1 mg/ml Injection Isoket Treatment for angina pectoris and left ventricular failure hyperthyroidism, hypertrophic, cardiomyopathy,
to 20 mg/hour may be required tachycardia symptomatic hypotension antihypertensive, sildenafil and tricyclic
hypotension,methemoglobinemia, recent head
antidepressant
trauma, severe anemia, volume depletion
i) 30 - 120 mg daily in divided doses ii) 40 - 160 mg, up hemorrhage,congestive heart failure, glaucoma,
Prophylaxis and treatment for: i) Angina ii) Left GI disturbances, headache, hypotension, Hypersensitivity to organic nitrates, anaemia, alcohol, beta-blocker, calcium channel blocker,
Isosorbide Dinitrate 10 mg Tablet Isordil to 240 mg if required; in acute episodes: 5 - 10 mg by hyperthyroidism,hypertrophic, cardiomyopathy,
ventricular failure tachycardia symptomatic hypotension antihypertensive, sildenafil, tricyclic
sublingually hypotension,methemoglobinemia, recent head
antidepressant
hemorrhage,congestive heart failure, glaucoma,
Isosorbide Mononitrate 50 mg SR GI disturbances, headache, hypotension, Hypersensitivity to organic nitrates, anaemia, alcohol, beta-blocker, calcium channel blocker,
Elantan Prophylaxis and treatment of angina pectoris 50 mg daily hyperthyroidism,hypertrophic, cardiomyopathy,
Capsule tachycardia symptomatic hypotension antihypertensive, sildenafil and tricyclic
antidepressant
Acute myocardial infarction,cerebral hemorrhage,
congestive heart failure, glaucoma, hyperthyroidism,
Isosorbide-5-Mononitrate 30 mg SR GI disturbances, headache, hypotension, Hypersensitivity to organic nitrates, anaemia, alcohol, beta-blocker, calcium channel blocker,
Imdur Prophylaxis and treatment of angina pectoris 30-120 mg daily hypertrophic, cardiomyopathy,
Tablet tachycardia symptomatic hypotension antihypertensive, sildenafil and tricyclic
antidepressant
Acute myocardial infarction,cerebral hemorrhage,
congestive heart failure, glaucoma, hyperthyroidism,
Isosorbide-5-Mononitrate 60 mg SR GI disturbances, headache, hypotension, Hypersensitivity to organic nitrates, anaemia, alcohol, beta-blocker, calcium channel blocker,
Imdur Prophylaxis and treatment of angina pectoris 30-120 mg daily hypertrophic, cardiomyopathy,
Tablet tachycardia symptomatic hypotension antihypertensive, sildenafil and tricyclic
antidepressant
Dry mucosa, dermatitis facialis, pruritus,
sweating. Occasionally, reversible alopecia,
Pregnancy and lactation. Hepatic or renal Concurrent use with vitamin A intensifies
Only for treatment of i) Severe nodulo-cystic acne ii) Diabetes, obesity, alcoholism, disturbances of lipid muscle and joint pain. Rarely, inflammatory
Initially: 0.5 mg/kg body weight daily (in one to or two insufficiency. Hypervitaminosis A. Patients with symptoms of hypervitaminosis A. Doxycycline,
Acne conglobata iii) Acne fulminans iv) Severe acne metabolism and childbearing potential, bowel disease, hyperuricaemia, benign
Isotretinoin 10 mg Capsule Roaccutane divided doses) with food once. Maintenance: 0.1 - 1 excessively elevated blood lipid values. minocycline, tetracycline may result in
vulgaris failing conventional treatment WARNING: hepatotoxicity, inflammatory bowel disease, nursing intracranial hypertension, visual disturbances
mg/kg daily body weight Concomitant tetramycin therapy. Hypersensitivity pseudotumour cerebri. Ethanol - a disulfiram-like
THIS DRUG IS TERATOGENIC mothers, visual problems, corneal opacities and photosensitivity reactions. Haematuria or
to isotretinoin products or paraben reaction. Food - Increases its bioavailability
proteinuria, hirsutism, pancreatitis,
lymphadenopathy
Dry mucosa, dermatitis facialis, pruritus,
sweating. Occasionally, reversible alopecia,
Pregnancy and lactation. Hepatic or renal Concurrent use with vitamin A intensifies
Only for treatment of i) Severe nodulo-cystic acne ii) Diabetes, obesity, alcoholism, disturbances of lipid muscle and joint pain. Rarely, inflammatory
Initially: 0.5 mg/kg body weight daily (in one to or two insufficiency. Hypervitaminosis A. Patients with symptoms of hypervitaminosis A. Doxycycline,
Acne conglobata iii) Acne fulminans iv) Severe acne metabolism and childbearing potential, bowel disease, hyperuricaemia, benign
Isotretinoin 20 mg Capsule Roaccutane divided doses) with food once. Maintenance: 0.1 - 1 excessively elevated blood lipid values. minocycline, tetracycline may result in
vulgaris failing conventional treatment WARNING: hepatotoxicity, inflammatory bowel disease, nursing intracranial hypertension, visual disturbances
mg/kg daily body weight Concomitant tetramycin therapy. Hypersensitivity pseudotumour cerebri. Ethanol - a disulfiram-like
THIS DRUG IS TERATOGENIC mothers, visual problems, corneal opacities and photosensitivity reactions. Haematuria or
to isotretinoin products or paraben reaction. Food - Increases its bioavailability
proteinuria, hirsutism, pancreatitis,
lymphadenopathy
Leukopenia, thrombocytopenia, anaphylactic
Treatment of gastrointestinal symptoms of functional, Enhances the action of acetylcholine and may
reaction, dizziness, headache, tremor,
non-ulcer dyspepsia (chronic gastritis) i.e sensation of produce cholinergic side effects. Pregnancy and Gastrointestinal haemorrhage, mechanical
Itopride HCl 50 mg Tablet Ganaton 50 mg 3 times daily before meal gastrointestinal disturbance, jaundice, rash, Reduced effect with anticholinergic drugs
bloating, early satiety, upper abdominal pain or lactation, elderly, renal and hepatic impairement, obstruction or perforation
redness, itching, acute dystonic reaction,
discomfort, anorexia, heartburn, nausea and vomiting mental depression
abdominal pain
i) 200 mg daily in 2 intakes, or in 1 intake, for 1 week. If
no response after 1 week, continue treatment for Lactation, history of liver or renal disease, children, Rifampicin& phenytoin reduce oral bioavailability
Rash, hypokalemia, diarrhoea, nausea and
Treatment of: i) oral and/or oesophageal candidiasis ii) another week ii) 100 - 200 mg twice daily for 2 weeks. If decreased gastric acidity. Patients with risk factors of itraconazole. Inhibits metabolism of warfarin,
Itraconazole 10 mg/ml Oral Solution Sporanox vomiting, Stevens-Johnson syndrome, Pregnancy, hypersensitivity to itraconazole
fluconazole resistant and/or oesophageal candidiasis no response after 2 weeks, continue treatment for for congestive heart failure such as ischaemic and digoxin, terfenadine, cyclosporin A, astemizole,
neutropenic disorder, hepatotoxicity, anaphylaxis
another 2 weeks. The 400 mg daily dose should not be valvular cardiac disease cisapride, oral midazolam
used for more than 14 days
i) 200 mg once daily for 7 days ii) 100 mg daily for 15

i) Dermatomycosis including pityriasis versicolor ii) Oral Lactation, history of liver or renal disease, children, Rifampicin& phenytoin reduce oral bioavailability
days iii) 200 mg twice daily for 7 days iv) 200 mg twice Rash, hypokalemia, diarrhoea, nausea and
candidiasis iii) Palmar tinea manus and plantar tinea decreased gastric acidity. Patients with risk factors of itraconazole. Inhibits metabolism of warfarin,
Itraconazole 100 mg Capsule Sporanox daly for 1 week/month v) 200 mg twice daily for 1 vomiting, Stevens-Johnson syndrome, Pregnancy, hypersensitivity to itraconazole
pedis iv) Fingernail onychomycosis v) Toenail for congestive heart failure such as ischaemic and digoxin, terfenadine, cyclosporin A, astemizole,
week/month for 3 months vi) 200 mg morning and neutropenic disorder, hepatotoxicity, anaphylaxis
onychomycosis vi) Vulvovaginal candidiasis valvular cardiac disease cisapride, oral midazolam
evening for 1 day or 200 mg once daily for 3 days
Resting heart rate below 60 beats per minute
Mild heart failure including asymptomatic left prior to treatment, cardiogenic shock, acute
Luminous phenomena (phosphenes), blurred
ventricular dysfunction, atrial fibrillation or other myocardial infarction, severe hypotension (less QT-prolonging drugs, CYP3A4 inhibitors (eg
Initial dose 5 mg twice daily. May increase dose after 3- vision, bradycardia, first degree AV block,
Symptomatic treatment of chronic stable angina arrythmias, second degree AV-block, CHF, stroke, than 90/50 mmHg), severe hepatic insufficiency, azole antifungals, macrolides, HIV protease
4 weeks to 7.5 mg twice daily depending on response. ventricular extrasystoles, muscle cramps,
Ivabradine 5 mg Tablet Coralan pectoris in patients with normal sinus rhythm, who have retinitis pigmentosa, galactose intolerance, sick sinus syndrome, sino-atrial block, severe inhibitors, nefazodone, diltiazem & verapamil) &
ELDERLY, initial dose 2.5 mg twice daily and titrate to a eosinophilia, dyspnoea, palpitation,
a contraindication or intolerance to beta blockers hypotension, congenital QT syndrome, moderate heart failure, pacemaker-dependent, unstable inducers (eg rifampicin, barbiturates, phenytoin,
maximum of 7.5 mg twice daily hyperuricaemia, raised plasma-creatinine
hepatic insufficiency, severe renal insufficiency, angina, AV-block of third degree, combination St. John's wort), grapefruit juice
concentration
elderly with strong cytochrome P450 3A4 inhibitors,
Resting heart rate below 60 beats per minute
Mild heart failure including asymptomatic left prior to treatment, cardiogenic shock, acute
Luminous phenomena (phosphenes), blurred
ventricular dysfunction, atrial fibrillation or other myocardial infarction, severe hypotension (less QT-prolonging drugs, CYP3A4 inhibitors (eg
Initial dose 5 mg twice daily. May increase dose after 3- vision, bradycardia, first degree AV block,
Symptomatic treatment of chronic stable angina arrythmias, second degree AV-block, CHF, stroke, than 90/50 mmHg), severe hepatic insufficiency, azole antifungals, macrolides, HIV protease
4 weeks to 7.5 mg twice daily depending on response. ventricular extrasystoles, muscle cramps,
Ivabradine 7.5 mg Tablet Coralan pectoris in patients with normal sinus rhythm, who have retinitis pigmentosa, galactose intolerance, sick sinus syndrome, sino-atrial block, severe inhibitors, nefazodone, diltiazem & verapamil) &
ELDERLY, initial dose 2.5 mg twice daily and titrate to a eosinophilia, dyspnoea, palpitation,
a contraindication or intolerance to beta blockers hypotension, congenital QT syndrome, moderate heart failure, pacemaker-dependent, unstable inducers (eg rifampicin, barbiturates, phenytoin,
maximum of 7.5 mg twice daily hyperuricaemia, raised plasma-creatinine
hepatic insufficiency, severe renal insufficiency, angina, AV-block of third degree, combination St. John's wort), grapefruit juice
concentration
elderly with strong cytochrome P450 3A4 inhibitors,
i) ADULT: 1 - 2 g daily IM in 1 - 2 equally divided doses. Use with blood substitute or diuretics aggravates
i) Treatment of gonorrhoea and neonatal meningitis ii)
CHILD: 30 - 50 mg/kg/day in 1 - 2 divided doses ii) Renal impairment, elderly, poor oral or parenteral Ototoxicity, nephrotoxicity. Rarely, shock, vitamin ototoxicity and nephrotoxicity. Respiratory
Kanamycin 1 g Injection - Treatment of TB patients who require reserved second Hypersensitivity to other aminoglycosides
ADULT: 2 g daily IM in 2 equally divided doses twice a nutrition. Pregnancy and lactation K& vitamin B deficiency depression with anaesthetics or muscle
line drugs but have no pre-existing renal complications
week or 1 g once daily 3 days a week relaxants
Cardiovascular stimulation, increased arterial
pressure, tachycardia, emergence phenomena
(hallucination and other transient psychotic
Atracurium, metrizamide, theophylline, tramadol,
squelae, vivid dreams), muscle hyperactivity.
Those prone to hallucinations, severe coronary heart Hypersensitivity to ketamine products, conditions tubocurarine, barbiturates, opioid. Inhalational
Irrational behaviour. Increased muscle tone
Sole anaesthetic for short procedures or induction of disease, eclampsia/pre-eclampsia, history of where hypertension is hazardous. History of anaesthetics and cerebral depressants may
IV - onset 30 sec : 2 mg/kg body weight or IM - onset 3 - sometimes resembling seizures. Temporary
Ketamine 10 mg/ml Injection Ketalar anaesthesia in certain types of patients (e.g in shock convulsive or psychiatric disorders, raised cardiovascular accident; severe angina, prolong effect of ketamine and delay recovery.
4 min : 10 mg/kg body weight hypertension, hypotension, bradycardia,
states) intracranial or intraocular pressure. Glaucoma, myocardial infarction, raised ocular and Prolonged recovery with concomitant use of
arrhythmias. respiratory depression, apnoea,
elderly, alcoholics, epilepsy intracranial pressure, psychiatric disorders barbiturates and/or opioids. Sustained
laryngospasm, diplopia, nystagmus; nausea,
hypertension with thyroid hormones
vomiting, lachrymation; hypersalivation; raised
intraocular and cerebrospinal fluid pressure; skin
irritation and pain at injection site
Cardiovascular stimulation, increased arterial
pressure, tachycardia, emergence phenomena
(hallucination and other transient psychotic
Atracurium, metrizamide, theophylline, tramadol,
squelae, vivid dreams), muscle hyperactivity.
Those prone to hallucinations, severe coronary heart Hypersensitivity to ketamine products, conditions tubocurarine, barbiturates, opioid. Inhalational
Irrational behaviour. Increased muscle tone
Sole anaesthetic for short procedures or induction of disease, eclampsia/pre-eclampsia, history of where hypertension is hazardous. History of anaesthetics and cerebral depressants may
IV - onset 30 sec : 2 mg/kg body weight or IM - onset 3 - sometimes resembling seizures. Temporary
Ketamine 50 mg/ml Injection Ketalar anaesthesia in certain types of patients (e.g in shock convulsive or psychiatric disorders, raised cardiovascular accident; severe angina, prolong effect of ketamine and delay recovery.
4 min : 10 mg/kg body weight hypertension, hypotension, bradycardia,
states) intracranial or intraocular pressure. Glaucoma, myocardial infarction, raised ocular and Prolonged recovery with concomitant use of
arrhythmias. respiratory depression, apnoea,
elderly, alcoholics, epilepsy intracranial pressure, psychiatric disorders barbiturates and/or opioids. Sustained
laryngospasm, diplopia, nystagmus; nausea,
hypertension with thyroid hormones
vomiting, lachrymation; hypersalivation; raised
intraocular and cerebrospinal fluid pressure; skin
irritation and pain at injection site
Concurrent use with ethanol may result in a
Apply twice weekly for 2 - 4 weeks. Prophylaxis: Once Local irritation, pruritus, alopecia and
Ketoconazole 2% Shampoo Nizoral Resistant dandruff only After prolonged treatment with topical corticosteroids Known hypersensitivity to ketoconazole products disulfiram-like reaction (flushing, vomiting,
every 1 - 2 weeks photosensitivity
increased respiratory rate, tachycardia)
Antacids, H2 receptor antagonist, antimuscarinic
i) 200 mg with meal once daily for 10 days ii) 200 - 400 GI disturbances; pruritus; elevated liver function
i) Pityriasis versicolor ii) Systemic mycosis (other skin Adrenal insufficiency or borderline adrenal function, Liver disease, recovery phase of hepatitis, agents, alcohol, warfarin, prednisolone,
Ketoconazole 200 mg Tablet Nizoral mg daily for 4 weeks - 6 months iii) 200 - 400 mg daily tests. Rarely, acute allergic reactions, hepatitis,
mycoses) iii) Nail infections prolonged periods of stress, pregnancy & lactation known hypersensitivity quinidine, cyclosporin, phenytoin, rifampicin, oral
for 6 - 12 months. Maximum 400 mg daily gynaecomastia, photophobia, alopecia
contraceptives
Renal impairment. Increased risk of serious
cardiovascular thrombotic events, myocardial
Active peptic ulceration, history of recurrent
infarction and stroke; risk may increase with duration
peptic ulcer or chronic dyspepsia, asthma, alergy
By deep IM into gluteal muscle, 50-100 mg every 4 of use and in patients at risk for cardiovascular Gastrointestinal disturbances, headache,
To be used only in treatment of acute inflammatory provoked by aspirin or NSAIDs. Treatment of NSAIDs, methotrexate, highly protein bound
Ketoprofen 100 mg/2ml Injection Orudis hours. Maximum 200 mg in 24 hours for up to 3 days. disease. Increased risk of serious gastrointestinal drowsiness, oedema, rashes, insomnia,
conditions peri-operative pain in setting of coronary artery drugs
Child not recommended adverse events (bleeding, ulceration, perforation of constipation, flatulence
bypass graft (CABG) surgery hypersensitivity to
stomach or intestines) that can occur at any time and
ketoprofen
without warning, higher risk in elderly or debilitated
patients
Avoid in children less than 5 years. If skin rash Avoid in patient with exudative dermatoses,
As a short term treatment for traumatic lesions, sprains,
Ketoprofen 2.5% Gel Orudis Apply twice daily. Maximum 20 g daily occurs after gel application, treatment should be Pruritus and localised erythema eczema, sores, infected skin. Do not apply to the Not known
tendinitis, oedema, bruises
stopped mucous membranes or eyes
Renal impairment. Increased risk of serious
Active peptic ulceration, history of recurrent
cardiovascular thrombotic events, myocardial
peptic ulcer or chronic dyspepsia. Patients who
infarction and stroke, risk may increase with duration
have experienced asthma, urticaria or allergic-
of use and in patients at risk for cardiovascular Gastrointestinal disturbances, headache,
Ketoprofen 200 mg Slow Release type reactions after taking aspirin or other NSAIDs, methotrexate, highly protein bound
Oruvail Pain and inflammation in rheumatic disease 100-200 mg daily with food. Child not recommended disease increased risk of serious gastrointestinal drowsiness, oedema, rashes, insomnia,
Capsule nonsteroidal anti-inflammatory agents. Treatment drugs
adverse events (bleeding, ulceration, perforation of constipation, flatulence
of peri-operative pain in setting of coronary
stomach or intestines) that can occur at any time and
artery bypass graft (CABG) surgery
without warning; higher risk in elderly or debilitated
hypersensitivity to ketoprofen
patients
Treatment of signs & symptoms of arthritis deformans,
Avoid in children less than 5 years. If skin rash Avoid in patient with exudative dermatoses,
Ketoprofen 30 mg Transdermal periarthritis humero-scapularis, tendinitis, peritendinitis,
Ketotop Apply 1 plaster to the affected area twice daily occurs after application, treatment should be Pruritus and localised erythema. eczema sores & infected skin. Do not apply to Not known
Plaster sore muscle, swelling, pain resulting from trauma (eg.
stopped. Pregnancy the mucous membranes or eyes.
contusion, distorsion, sprain).
Antiplatelet, anticoagulant, aspirin, NSAIDs : may
i) Ocular itching due to allergic conjunctivitis ii) Bleeding tendencies, ocular surgery, dry eye Hpersensitivity to its component, aspirin, NSAIDs
Ketorolac Tromethamine 0.5% Eye i) 1 drop 4 times daily ii) 1 drop 4 times daily starting 24 Transient burning sensation in the eye, corneal increase ocular bleeding risk post-operation.
Acular Prophylaxis and reduction of inflammation and syndrome, diabetes mellitus, rheumatoid arthritis. or phenylacetic acid derivatives. Pregnancy third
drops hours post-operation, continue for 2 weeks edema, eye irritation Intraocular cholinergic agent : may decrease
associated symptoms following ocular surgery Avoid contact lens use trimester
cholinergic agent efficacy
Hystory of peptic ulcer or coagulation disorders,
hypersensitivity to ketorolac, NSAIDs, aspirin,
oxpentifylline, probenecid, lithium or other
prostaglandin synthesis inhibitors.
Bronchospasm, dyspnoea, gastrointestinal Gastrointestinal bleeding, suspected or
disturbances and ulceration, dizziness, confirmed cerebrovascular (intracranial)
drowsiness, dry mouth, hallucinations, bleeding, history of haemorrhagic diatheses, ACEIs : decreased antihypertensive and
Active hepatitis and cholestasis, conditions
headache, insomnia, myalgia, sweating, tinnitus, including coagulation disorders. Individuals with natriuretic effects. Aspirin, NSAIDs : enhanced
ADULT : By IM/IV injection.(over not less than 15 predisposing to GI toxicity, conditions predisposing
Ketorolac Tromethamine 30 mg/ml Short term management of moderate to severe vertigo, urinary tract and kidney disorders, complete or partial syndrome of nasal polyps, gastrointestinal adverse effects (peptic ulcers,
Toradol seconds.) Initially 15 mg 4 - 6 hourly. MAXIMUM: 90 mg to or exacerbated by fluid retention, cardiac or
Injection postoperative pain bradycardia, flushing, hypertension, pallor, angioedema or bronchospasm. Dehydration or gastrointestinal bleeding and or perforation) and
daily hepatic impairment, elderly. History of GIT disease,
purpura, thrombocytopenia, asthma, dyspnoea, hypovolaemia from any cause. Moderate or possible increase in serum ketorolac levels. Beta-
Coagulation disorders
pulmonary oedema, skin reactions, severe renal impairment (serum creatinine more adrenergic block
hypersensitivity reactions, bleeding, asthenia, than 180 mmol/L). History of asthma. Patients
injection site pain, weight gain who have had operations with a high risk of
haemorrhage or incomplete haemostasis.
Patients on anticoagulants including low dose
heparin. Pregnancy, labour, delivery or lactation.
Children less than 16 year
Alpha-1 adrenergic blockers, amiodarone,
Anaesthesia/surgery, including when used in cases
ADULT: 100 mg (50 mg in elderly) daily with food, Hypersensitivity to labetalol products, cimetidine, clonidine, digoxin, dihydropyridine,
to control bleeding (myocardial depression). Avoid
increased at intervals of 14 days to usual dose of 200 bradycardia, asthma/obstructive airway disease, calcium channel blockers, diltiazem, enflurane,
Labetalol HCl 100 mg Tablet Trandate Hypertension (including in pregnancy) abrupt withdrawal; gradual withdrawal over a period Hypotension, bradycardia, nausea, vomiting
mg twice daily, up to 800 mg twice daily (3 - 4 divided cardiogenic shock, heart block overt cardiac epinephrine, flunarizine, halothane,
of 1 to 2 weeks is recommended. Bronchospastic
doses if higher dose). Max: 2.4 g daily failure hypoglycemic agents, imipramine, isoflurane,
disease, congestive heart failure, diabetes mellitus
lidoflazine, methyldopa, verapamil
ADULT: Bolus injection 50 mg IV for at least 1 min. Anaesthesia/surgery, including when used in cases
Hypersensitivity to labetalol products, bepridil, cimetidine, clonidine, digoxin,
Max: 200 mg. IV infusion, dilute 2 amps to 200ml with to control bleeding (myocardial depression). Avoid
bradycardia, asthma/obstructive airway disease, dihydropyridine, calcium channel blockers,
Labetalol HCl 100 mg/20 ml Injection Trandate Hypertension crisis sodium chloride and dextrose injection or 5% dextrose abrupt withdrawal; gradual withdrawal over a period Hypotension, bradycardia, nausea, vomiting
cardiogenic shock, heart block overt cardiac diltiazem, enflurane, epinephrine, flunarizine,
IV infusion, Hypertension of pregnancy; 20mg per hour of 1 to 2 weeks is recommended. Bronchospastic
failure halothane, hypoglycemic agents, imipramine,
doubled every 30 min to max 160 mg per hour disease, congestive heart failure, diabetes mellitus
isoflurane, lidoflazine, methyldopa, verapamil
ADULT: 100 mg (50 mg in elderly) daily with food, Avoid abrupt withdrawal; gradual withdrawal over a Hypersensitivity to labetalol products, cimetidine, clonidine, digoxin, dihydropyridine,
increased at intervals of 14 days to usual dose of 200 period of 1 to 2 weeks is recommended. bradycardia, asthma/obstructive airway disease, calcium channel blockers, diltiazem, enflurane,
Labetalol HCl 200 mg Tablet Trandate Hypertension (including in pregnancy) Hypotension, bradycardia, nausea, vomiting
mg twice daily, up to 800 mg twice daily (3 - 4 divided Bronchospastic disease, congestive heart failure, cardiogenic shock, heart block overt cardiac epinephrine, flunarizine, halothane,
doses if higher dose). Max: 2.4 g daily diabetes mellitus failure hypoglycemic agents, imipramine, isoflurane,
lidoflazine methyldopa, verapamil
i) ADULT 15 ml twice daily adjusted to patient's need.
CHILD 0.5 ml/kg/dose once or twice daily ii) 30-50 ml 3- Diabetics, patients with lactose intolerance, Response may be altered by anti-infective
Lactulose 3.35 g/5 ml Liquid Duphalac i) Constipation ii) Hepatic encephalopathy Flatulence, cramps and abdominal discomfort Galactosaemia, intestinal obstruction
4 times daily, dose adjusted to produce 2-3 soft stools pregnancy, lactation agents
daily. CHILD 1 ml/kg/dose 3-4 times daily
Nausea, vomiting, diarrhoea, abdominal pain,
cough, headache, fatigue, insomnia, malaise,
ADULT: 150 mg twice daily or 300 mg once daily.
Moderate to severe renal impairment, advanced fever, rash, alopecia, muscle disorders, Hypersensitivity to lamivudine, abnormally low
HIV infection in combination with other antiretroviral INFANT under 1 month: 2 mg/kg twice daily. CHILD 1 Trimethoprim, interferon alfa, ribavirin,
Lamivudine 10 mg/ml Oral Solution 3TC cirrhotic liver disease, pregnancy, lactation, chronic peripheral neuropathy, pancreatitis, neutropenia, neutrophil counts or abnormally low haemoglobin
agents month or over: 4 mg/kg twice daily. Maximum 300 mg sulfamethoxazole, zalcitabine
hepatitis B or C, hepatic disease anaemia, thrombocytopenia and red-cell aplasia, levels
daily
lactic acidosis, raised liver enzymes and serum
amylase, hepatomegaly
cough; headache, fatigue, insomnia, malaise,
Management of chronic hepatitis B infection associated Moderate to severe renal impairment, advanced fever, rash, alopecia, muscle disorders, Hypersensitivity to lamivudine, abnormally low
ADOLESCENTS more than 16 years and ADULTS: 100 Trimethoprim, interferon alfa, ribavirin,
Lamivudine 100 mg Tablet Zeffix with evidence of hepatitis B viral replication and active cirrhotic liver disease, pregnancy, lactation, chronic peripheral neuropathy, pancreatitis, neutropenia, neutrophil counts or abnormally low haemoglobin
mg/dose once daily sulfamethoxazole, zalcitabine
liver inflammation hepatitis B or C, hepatic disease anaemia, thrombocytopenia and red-cell aplasia, levels
cough; headache, fatigue, insomnia, malaise,
ADULT: 150 mg twice daily or 300 mg once daily.
Moderate to severe renal impairment, advanced fever, rash, alopecia, muscle disorders, Hypersensitivity to lamivudine, abnormally low
HIV infection in combination with other antiretroviral INFANT under 1 month: 2 mg/kg twice daily. CHILD 1 Trimethoprim, interferon alfa, ribavirin,
Lamivudine 150 mg Tablet 3TC cirrhotic liver disease, pregnancy, lactation, chronic peripheral neuropathy, pancreatitis, neutropenia, neutrophil counts or abnormally low haemoglobin
agents month or over: 4 mg/kg twice daily. Maximum 300 mg sulfamethoxazole, zalcitabine
hepatitis B or C, hepatic disease anaemia, thrombocytopenia and red-cell aplasia, levels
daily
Concomitant use of other antiepileptics, discontinue
therapy at the first sign of rash, renal, hepatic or
Dizziness, fatigue, headache, hypersensitivity
cardiac impairment, pregnancy, lactation. Closely Metabolism is increased by carbamazepine,
reactions, rashes, malaise, leukopenia,
monitor and consider withdrawal if hypersensitivity phenobarbital, phenytoin and primidone,
i) Adjunctive or monotherapy for partial seizures and thrombocytopenia, photosensitivity, blurred
syndrome develops. Avoid abrupt withdrawal decreased by valproate. Central nervous system
generalised tonic-clonic seizures not satisfactorily vision, conjunctivitis, drowsiness, insomnia,
(reduce dosage stepwise over a period of 2 week) events occur with carbamazepine. Rifampicin,
controlled with other antiepileptic drugs ii) Prevention of i) Up to 200 mg daily in single or divided dosage ii) 25- ataxia, nausea. Irritability, drowsiness, insomnia, Hypersensitivity to lamotrigine products, hepatic
Lamotrigine 100 mg Tablet Lamictal unless serious skin reaction occurs. Significant ethinyloestradiol/levonorgestrel combination
mood episodes in adult 18 years and above with 200 mg daily tremor, nystagmus, ataxia, diplopia, blurred impairment
hepatic or renal impairment. Monitor and adjust dose enhances the metabolism of lamotrigine. Sodium
bipolar disorder, predominately by preventing vision, gastrointestinal disturbances, arthralgia,
if necessary in women who are starting or stopping valproate reduces the metabolism of lamotrigine.
depressive episodes pain including back pain. Rarely, severe skin
hormonal contraceptives during Lamictal therapy. Possible interference with folate metabolism
reactions including Stevens-Johnson syndrome
Close supervision of patients at high risk of suicide during long-term therapy
and toxic epidermal necrolysis
in bipolar disorder. Potential of an increase in risk of
suicidal thoughts or behaviours
cardiac impairment, pregnancy, lactation. Closely Fatigue, headache, hypersensitivity reactions,
Central nervous system events occur with
monitor and consider withdrawal if hypersensitivity rashes, malaise, leukopenia, thrombocytopenia,
carbamazepine. Phenytoin, carbamazepine,
syndrome develops, avoid abrupt withdrawal photosensitivity, blurred vision, conjunctivitis,
phenobarbital, primidone, rifampicin,
(reduce dosage stepwise over a period of 2 week) nausea, irritability, drowsiness, insomnia,
Lamotrigine 25 mg Hypersensitivity to lamotrigine products, hepatic ethinyloestradiol/levonorgestrel combination
Lamictal Dispersible Add-on therapy in intractable partial seizures 25 mg daily - 50 mg twice daily unless serious skin reaction occurs. Significant dizziness, tremor, nystagmus, ataxia, diplopia,
Dispersible/Chewable Tablet impairment enhance the metabolism of lamotrigine. Sodium
hepatic or renal impairment. Monitor and adjust dose blurred vision, gastrointestinal disturbances,
valproate reduces the metabolism of lamotrigine.
if necessary in women who are starting or stopping arthralgia, pain including back pain. Rarely,
Possible interference with folate metabolism
hormonal contraceptives during lamictal therapy. severe skin reactions including Stevens-Johnson
during long-term therapy
Close supervision of patients at high risk of suicide syndrome and toxic epidermal necrolysis
in bipolar disorder. Potential for an increase in risk of
a) Add-on therapy in patients not taking Valproate: cardiac impairment, pregnancy, lactation. Closely Fatigue, headache, hypersensitivity reactions,
Central nervous system events occur with
week 1 and 2: 2 mg/kg/day twice daily, week 3 and 4: 5 monitor and consider withdrawal if hypersensitivity rashes, malaise, leukopenia, thrombocytopenia,
carbamazepine. Phenytoin, carbamazepine,
mg/kg/day twice daily. Maintenance: 5 - 15 mg/kg/day syndrome develops, avoid abrupt withdrawal photosensitivity, blurred vision, conjunctivitis,
phenobarbital, primidone, rifampicin,
twice daily b) Add-on therapy in patients taking (reduce dosage stepwise over a period of 2 week) nausea, irritability, drowsiness, insomnia,
Lamotrigine 5 mg Hypersensitivity to lamotrigine products, hepatic ethinyloestradiol/levonorgestrel combination
Lamictal Dispersible Management of seizures in children aged 2 - 12 years Valproate or other anti-epileptic drugs, week 1 and 2: unless serious skin reaction occurs. Significant dizziness, tremor, nystagmus, ataxia, diplopia,
Dispersible/Chewable Tablet impairment enhance the metabolism of lamotrigine. Sodium
0.2 mg/kg/day as a single dose (children less than 25 hepatic or renal impairment. Monitor and adjust dose blurred vision, gastrointestinal disturbances,
valproate reduces the metabolism of lamotrigine.
kg may take 5 mg on alternate days), week 3 and 4: 0.5 if necessary in women who are starting or stopping arthralgia, pain including back pain. Rarely,
Possible interference with folate metabolism
mg/kg/day as a single dose. Maintenance dose: 1 -5 hormonal contraceptives during lamictal therapy. severe skin reactions including Stevens-Johnson
during long-term therapy
mg/kg/day once daily or twice daily Close supervision of patients at high risk of suicide syndrome and toxic epidermal necrolysis
in bipolar disorder. Potential for an increase risk of
Dizziness, fatigue, headache, hypersensitivity
cardiac impairment, pregnancy, lactation. Closely Metabolism is increased by carbamazepine,
reactions, rashes, malaise, leukopenia,
monitor and consider withdrawal if hypersensitivity phenobarbital, phenytoin and primidone,
i) Adjunctive or monotherapy for partial seizures and thrombocytopenia, photosensitivity, blurred
syndrome develops. Avoid abrupt withdrawal decreased by valproate. Central nervous system
generalised tonic-clonic seizures not satisfactorily vision, conjunctivitis, drowsiness, insomnia,
(reduce dosage stepwise over a period of 2 week) events occur with carbamazepine. Rifampicin,
controlled with other antiepileptic drugs ii) Prevention of i) Up to 200 mg daily in single or divided dosage ii) 25- ataxia, nausea. Irritability, drowsiness, insomnia, Hypersensitivity to lamotrigine products, hepatic
Lamotrigine 50 mg Tablet Lamictal unless serious skin reaction occurs. Significant ethinyloestradiol/levonorgestrel combination
mood episodes in adult 18 years and above with 200 mg daily tremor, nystagmus, ataxia, diplopia, blurred impairment
hepatic or renal impairment. Monitor and adjust dose enhances the metabolism of lamotrigine. Sodium
bipolar disorder, predominately by preventing vision, gastrointestinal disturbances, arthralgia,
if necessary in women who are starting or stopping valproate reduces the metabolism of lamotrigine.
depressive episodes pain including back pain. Rarely, severe skin
hormonal contraceptives during Lamictal therapy. Possible interference with folate metabolism
reactions including Stevens-Johnson syndrome
Close supervision of patients at high risk of suicide during long-term therapy
and toxic epidermal necrolysis
in bipolar disorder. Potential for an increase in risk of
Avoid contact with eyes. Not to be applied over deep Possible allergic reaction to material if inhaled,
Lanolin - As an emollient Apply to the affected area Hypersensitivity to lanolin Not known
or puncture wounds, infections or lacerations ingested or in contact with skin
i) 30 mg daily for 8 weeks ii) 30 mg once 1-2 times daily
for 4-8 weeks iii) 60-120mg once daily adjusted May retard metabolism and excretion of
i) Peptic ulcer disease ii) Reflux oesophagitis iii) according to the patient's response iv) 30 mg twice Agitation, constipation, diarrhoea, dry mouth, Hypersensitivity to lansoprazole, in patients with diazepam and phenytoin. May decrease plasma
Lansoprazole 30 mg Tablet Prevacid Zollinger-Ellison Syndrome iv) For eradication of daily in combination with any of the 2 antibiotics Hepatic impairment, elderly, pregnancy, lactation abdominal distension, headache, sleepiness, known hypersensitivity to any component of the concentration of theophylline, inhibition of gastric
Helicobacter pylori in combination with antibiotic (clarithromycin 500 mg twice daily , amoxicillin 1 g twice insomnia, dizziness, rash, pruritus, fever formulation acid secretion may interfere with dissolution of
daily or metronidazole 400 mg twice daily) for 1-2 the drug
weeks
Phosphate binding agent for the treatment of Initial: 750 to 1500 mg/day in divided doses with meals, Caution when used in patients with acute peptic Possibly reduces absorption of ketoconazole,
Gastrointestinal disturbances, including nausea,
Lanthanum Carbonate 1000mg hyperphosphataemia in dialysis patients with sustained then titrate in increments of 750 mg/day at intervals of 2 ulcer, ulcerative colitis, Crohn's disease or bowel Specific contraindications have not been chloroquine, hydroxychloroquine or other
Fosrenol vomiting, constipation, diarrhoea, dyspepsia and
Chewable Tablet hypercalcaemia of more than three months and to 3 weeks. Maintenance: 1500-3000 mg/day in divided obstruction. Tablets should be thoroughly chewed determined compounds that are known to interact with
abdominal pain
secondary hyperparathyroidism doses. Max: 3750 g/day before swallowing. Pregnancy and lactation antacids (give at least 2 hours apart)
Hypersensitivity reactions (urticaria, chills, fever,

anaphylaxis), hyperglycaemia, lethargy,
i) 5,000 iu/m2 for 10 days during induction, 10,000 depression, confusion, coagulopathy, anorexia,
iu/m2 also used with high dose methotrexate rescue in Haematologic, renal and hepatic dysfunction, mild nausea and vomiting, acute pancreatitis,
i) Acute lymphoblastic leukemia ii) Non-hodgkin's Hypersensitivity to L-Asparaginase, history of Vincristine, cyclophosphamide, methotrexate,
L-Asparaginase 10,000 IU Injection Leunase consolidation phase of acute lymphoblastic leukemia ii) pregnancy. Monitor for severe allergic reactions, coma, myelosuppression (usually mild), hepatic
lymphoma pancreatitis steroids, live vaccine
CHILD: 5,000 - 25,000 iu/m2 per dose depending on caution in underlying coagulopathy and lactation dysfunction, renal dysfunction, somnolence,
protocol hallucination, central nervous system
disturbances including depression, coma,
transient bone-marrow depression
Inflammatory, neovascular, angle closure or
The recommended dosage is one drop (1.5 µg) in the Effects additive to beta-adrenergic antagonist,
congenital glaucoma, open angle glaucoma of Slight discomfort, mild to moderate conjunctival
Reduction of elevated intraocular pressure in patients affected eye(s) once daily in the evening. If more than Known hypersensitivity to any component of the adrenergic agonists, carbonic anhydrase
Latanoprost 0.005% Eye Drops Xalatan pseudophakic patients, pigmentary glaucoma, acute hyperaemia, transient punctate ephitelial
with open-angle glaucoma one topical ophthalmic drug is being used, the drugs products inhibitors and cholinergic agonists. Other eye
attacks of closed angle glaucoma, pregnancy and erosions, increased pigmentation of iris, rash
should be administered at least five (5) minutes apart preparation containing thiomersal
lactation. Contact lens users
Gastrointestinal disturbances, anorexia, oral
mucosa ulceration, elevation of liver parameters, Severe immunodeficiency state, serious
headache, dizziness, paraesthesias, increase infection, hepatic impairment, severe
i) Persistent active rheumatoid arthritis ii) Active Loading dose: 100 mg once daily for 3 days. Renal impairment, anaemia, leucopenia, blood pressure, weight loss, increase hair loss, hypoproteinaemia, pregnancy, lactation, Other antirheumatic or immuno-suppressive
Leflunomide 10 mg Tablet Arava
psoriatic arthritis Maintenance: 10-20 mg once daily thrombocytopenia, history of tuberculosis eczema, dry skin, mild allergic reactions, significantly impaired bone marrow function or agents, alcohol, phenytoin, warfarin, tolbutamide
leucopenia, mild hyperlipidaemia. Rarely, significant anaemia, leucopenia, neutropenia or
Stevens-Johnson syndrome, toxic epidermal thrombocytopenia
necrolysis, erythema multiforme

psoriatic arthritis Maintenance: 10-20 mg once daily thrombocytopenia, history of tuberculosis eczema, dry skin, mild allergic reactions, significantly impaired bone marrow function or agents, alcohol, phenytoin, warfarin, tolbutamide

psoriatic arthritis Maintenance: 10-20 mg once daily. thrombocytopenia, history of tuberculosis eczema, dry skin, mild allergic reactions, significantly impaired bone marrow function or agents, alcohol, phenytoin, warfarin, tolbutamide
i) Treatment of hormone responsive metastatic or

locally advance breast cancer after failure of tamoxifen
Impaired liver function. Only to be used in
ii) Adjunct for node positive postmenopausal women Headache, nausea, fatigue, arthralgia,
postmenopausal women. Cirrhosis and severe Inhibitors of the cytochrome P450 enzymes,
Letrozole 2.5 mg Tablet Femara with early breast cancer (positive or unknown 2.5 mg once daily musculoskeletal pain, hot flushes, facture of Hypersensitivity to letrozole, pregnancy, lactation
hepatic dysfunction, risk of drug toxicity pregnancy, tamoxifen
oestrogen or positive progesterone receptor status / bone, heart failure, myocardial infarction
potential for maternal and fetal malformations
receptor status) who have received 5 years of adjuvant
tamoxifen therapy
Hypersensitivity to leucovorin, pernicious
Leucovorin Calcium (Calcium Anaphylatoid reactions, urticaria, nausea,
Treatment of folic acid antagonist overdose 15 mg every 6 hours for the next 48 - 72 hours Pregnancy, lactation, seizure disorder anaemia or megaloblastic anaemia where Phenobarbitone, phenytoin
Folinate) 15mg Tablet vomiting
vitamin B12 is deficient
i) 20 mg/m2 daily for 5 days before 5-Fluorouracil or
200 mg/m2 IV infusion over 2 hours prior to 5-
i) Biochemical modulator for 5-Fluorouracil in the
Fluorouracil on Day 1 and Day 2 (refer specific Hypersensitivity to leucovorin, pernicious
Leucovorin Calcium (Calcium treatment of colorectal cancer ii) As rescue for high Anaphylatoid reactions, urticaria, nausea,
Leucovorin Calcium protocol) ii) Starting 24 - 42 hours of methotrexate Pregnancy, lactation, seizure disorder anaemia or megaloblastic anaemia where Phenobarbitone, phenytoin
Folinate) 3 mg Injection dose methotrexate iii) Megaloblastic anaemias due to vomiting
administration, doses usually 15-30 mg/m2 every 6 vitamin B12 is deficient
deficiency of folic acid
hours for 3 to 6 doses depending on protocol iii) 1 mg
orally 4 times daily
i) 20 mg/m2 daily for 5 days before 5-Fluorouracil or
200 mg/m2 IV infusion over 2 hours prior to 5-
Fluorouracil on Day 1 and Day 2 or 500 mg/m2 IV Day
1 weekly (refer to specific protocol) ii) Starting 24 - 42
i) Biochemical modulator for 5-Fluorouracil in the Hypersensitivity to leucovorin, pernicious
Leucovorin Calcium (Calcium hours of methotrexate administration, doses usually 15 - Anaphylatoid reactions, urticaria, nausea,
Leucovorin Calcium treatment of colorectal cancer ii) As rescue for high Pregnancy, lactation, seizure disorder anaemia or megaloblastic anaemia where Phenobarbitone, phenytoin
Folinate) 50 mg Injection 30 mg/m2 every 6 hours for 8 to 12 doses depending vomiting
dose methotrexate iii) Gestational trophoblastic disease vitamin B12 is deficient
on protocol and serum methotrexate levels iii) 6 - 12 mg
exactly 30 hours after each dose of methotrexate. In
EMA-CO regime for high risk gestational trophoblastic
disease, use 30 mg IM
Hot flashes, vaginal haemorrhage, bone pain,
Undiagnosed abnormal vaginal bleeding, congestive
nausea, vomiting, peripheral oedema,
heart failure or other conditions requiring sodium
gastrointestinal disturbances, dizziness,
i) Endometriosis ii) Hormonal therapy in advanced restriction, history of thromboembolism or Pregnancy, hypersensitivity to leuprolide
Leuprolide Acetate 11.25 mg Injection Lucrin 11.25 mg every 3 months headache, paraesthesia, congestive heart Not known
prostate cancer cardiovascular disease, metastatic vertebral lesions, products/GnRH agonists
failure, oedema, thrombophlebitis, breast
urinary tract obstruction history of osteoporosis,
tenderness, impotence, increases/decreases in
lactation, occurrence of memory disorders
certain hormone levels
Hot flashes,vaginal haemorrhage,bone pain,
Undiagnosed abnormal vaginal bleeding, congestive
nausea, vomiting, peripheral oedema,
heart failure or other conditions requiring sodium
gastrointestinal disturbances, dizziness,
i) Endometriosis ii) Hormonal therapy in advanced i) 3.75 mg monthly for 3 - 6 months ii) 3.75 mg IM or SC restriction, history of thromboembolism or Pregnancy, hypersensitivity to leuprolide
Leuprolide Acetate 3.75 mg Injection Lucrin Depot headache, paraesthesia, congestive heart Not known
prostate cancer injection monthly cardiovascular disease, metastatic vertebral lesions, products/GnRH agonists
failure, oedema, thrombophlebitis, breast
urinary tract obstruction history of osteoporosis,
tenderness, impotence, increases/decreases in
lactation, occurrence of memory disorders
certain hormone levels
CHILD: 4-11 years and adolescent (12-17 years) less Avoid abrupt discontinuation, renal impairment,
As adjunctive therapy in the treatment of partial onset than 50 kg: Initially 10 mg/kg twice daily, may be severe hepatic impairment, pregnancy, lactation,
Levetiracetam 100 mg/ml Oral Asthenia, somnolence, dizziness, anorexia,
Keppra seizures with or without secondary generalization in increased up to 30 mg/kg twice daily. Dose changes elderly. May affect ability to drive or operate Hypersensitivity to levetiracetam products Evening primrose, ginkgo
Solution diarrhoea, nausea, dyspepsia, rash, diplopia
adults and children from 4 years of age with epilepsy should not exceed increments or decrements of 10 machinery. Potential for an increase in risk of
mg/kg two times daily twice weekly suicidal thoughts or behaviours
i) Monotherapy ADULTS and ADOLESCENT (from 16
years) : Starting dose: 250 mg twice daily, Increase
dose to 500 mg twice daily after 2 week. Dose can be
further increased by 250 mg twice daily every 2 week
i) Monotherapy therapy in the treatment of partial onset depending upon the clinical response. Max: 1500 mg
seizures with or without secondary generalization in twice daily. ii) ADULT more than 18 years and
Avoid abrupt discontinuation, renal impairment,
patients from age 16 years of age with newly ADOLESCENT (12-17 years) more than or equal to 50
severe hepatic impairment, pregnancy, lactation,
diagnosed epilepsy ii) Adjunctive treatment in partial kg: Initially 500 mg twice daily may be increased up to Asthenia, somnolence, dizziness, anorexia,
Levetiracetam 250 mg Tablet Keppra elderly. May affect ability to drive or operate Hypersensitivity to levetiracetam products Evening primrose, ginkgo
onset seizures with or without secondary generalization 1500 mg twice daily. Dose changes can be made in diarrhoea, nausea, dyspepsia, rash, diplopia
machinery. Potential for an increase in risk of
in adults and children from 4 years of age with epilepsy; 500 mg twice daily increments or decrements 2-4
juvenile myoclonic epilepsy and idiopathic generalized weekly. CHILD (4-11 years) and ADOLESCENT (12-17
tonic clonic epilepsy from 12 years of age years) less than 50 kg : Initially 10 mg/kg twice daily,
may be increased up to 30 mg/kg twice daily. Dose
changes should not exceed increments or decrements
of 10 mg/kg twice daily every 2 weeks. CHILD more
than or equal to 50 kg: Adult dose
i) Monotherapy ADULTS and ADOLESCENT (from 16
years) : Starting dose: 250 mg twice daily, Increase
dose to 500 mg twice daily after 2 week. Dose can be
further increased by 250 mg twice daily every 2 week
i) Monotherapy therapy in the treatment of partial onset depending upon the clinical response. Max: 1500 mg
seizures with or without secondary generalization in twice daily. ii) ADULT more than 18 years and
Avoid abrupt discontinuation, renal impairment,
patients from age 16 years of age with newly ADOLESCENT (12-17 years) more than or equal to 50
severe hepatic impairment, pregnancy, lactation,
diagnosed epilepsy ii) Adjunctive treatment in partial kg: Initially 500 mg twice daily may be increased up to Asthenia, somnolence, dizziness, anorexia,
Levetiracetam 500 mg Tablet Keppra elderly. May affect ability to drive or operate Hypersensitivity to levetiracetam products Evening primrose, ginkgo
onset seizures with or without secondary generalization 1500 mg twice daily. Dose changes can be made in diarrhoea, nausea, dyspepsia, rash, diplopia
machinery. Potential for an increase in risk of
in adults and children from 4 years of age with epilepsy; 500 mg twice daily increments or decrements 2-4
juvenile myoclonic epilepsy and idiopathic generalized weekly. CHILD (4-11 years) and ADOLESCENT (12-17
tonic clonic epilepsy from 12 years of age years) less than 50 kg : Initially 10 mg/kg twice daily,
may be increased up to 30 mg/kg twice daily. Dose
changes should not exceed increments or decrements
of 10 mg/kg twice daily every 2 weeks. CHILD more
than or equal to 50 kg: Adult dose
Surgical anesthesia : Lumber epidural : 10 - 20 ml (50 -
150 mg) , caesarean section : 15 - 30 ml (75 - 150 mg), Use with caution in patients with hypotension, Hypotension, anemia, nausea, vomiting, fever,
Production of local or regional anesthesia for surgery Intravenous regional anaesthesia (Bier's block),
Levobupivacaine 5mg/ml Injection Chirocaine intrathecal: 3 ml (15 mg), peripheral nerve block : 1 - 40 hypovolemia, heart block, hepatic or cardiac pruritus, cardiac arrest, cardiac dysrhythmia, St John's Wort
and obstetrics, and for postoperative pain management paracervical block in obstetrics
ml, ilioinguinal/iliohypogastric block. CHILD : 0.25 - 0.5 impairment apnea
ml/kg (1.25-2.5 mg/kg)
Anorexia, nausea and vomiting, diarrhoea,
insomnia, agitation, cardiac arrhythmias, postural Hypertensive crisis with MAOIs, increased
Initial: 100/25 mg 1-2 times/day, increase every 3 - 4 Open-angle glaucoma, depression, diabetes, severe
hypotension (rarely labile hypertension), hypotensive effect with antihypertensives,
days until therapeutic effect, optimal dosage: 400/100 cardiovascular disease, bronchial asthma, renal,
dizziness, tachycardia, arrhythmias, reddish Hypersensitivity to this drug. Patient on MAOIs antagonism effect of antipsychotic, reduced
mg to 800/200 mg/day divided into 4 - 6 doses. Dose: hepatic or endocrine disease, history of psychoses
discoloration of urine and other body fluid, rarely therapy with decompensated endocrine, renal or absorption by iron, plasma concentration
200/50 mg used only when maintenance therapy is or convulsion. Lactation. Perform liver function and
Levodopa 100 mg and Benserazide hypersensitivity, abnormal involuntary hepatic function, cardiac disorders, psychiatric increased by metoclopramide. Tricylic
Madopar Dispersible Parkinson's Disease reached and not to exceed levodopa 1000 - 1200 blood count tests during treatment. Discontinue 12 -
25 mg Dispersible Tablet movement. Lost or change of taste. Abnormal diseases or closed-angle glaucoma. Pregnancy. antidepressant, phenothiazines, phenytoin,
mg/benserazide 250 - 300 mg per day. Dispersible 48 hour before surgery requiring general
involuntary movements. Rarely, skin reactions, Patients less than 25 years. Lactation. pyridoxine. Potentiates effects of
formulation for dysphagia or where a more rapid onset anaesthesia. If patient must undergo surgery without
haemolytic anaemia, mild, transient leukopenia Combination with MAOIs (except selegiline) sympathomimetics. Neuroleptics, opioids,
of action is required ie patients with early Madopar having been withdrawn, avoid anaesthesia
and thrombocytopenia. Agitation, anxiety, antihypertensives containing reserpine, antacid,
morning/afternoon akinesia with cyclopropane or halothane
insomnia, hallucination, delusion and temporal protein-rich meal
disorientation in the elderly
Central nervous system: Anxiety, confusion,

Not recommended for treatment of drug-induced
nervousness, mental depression, psychotic
extrapyramidal reactions. The occurrence of
symptoms. Anorexia, nausea and vomiting,
dyskinesias in patients previously treated with
diarrhoea, insomnia, agitation, postural Hypersensitivity to this drug. Patient on MAOIs
levodopa alone may require dosage reduction. All Hypertensive crisis with MAOIs, increased
hypotension, dizziness, chest pain, tachycardia, therapy or 2 weeks prior to initiating therapy.
Patients not receiving Levodopa before, initially 100 - patients should be observed carefully for the hypotensive effect with antihypertensives,
arrhythmias, reddish discoloration of urine and May be administered concomitantly with or an
125 mg 3 - 4 times daily adjusted according to development of depression with concomitant suicidal antagonism effect of antipsychotic, reduced
other body fluid. Dyskinesia, muscle twitching MAOI with or selectivity for MAO type B (eg
Levodopa 100 mg and Carbidopa 25 response. Maintenance: 0.75 - 2 g in divided doses. In tendencies. Cardiovascular disease or pulmonary absorption by iron, plasma concentration
Sinemet Parkinson's disease and blepharospasm may be taken as early signs selegiline HCl). Narrow-angle glaucoma with
mg Tablet patients previously treated with Levodopa the dose disease, bronchial asthma. Hepatic impairment, increased by metoclopramide. Linezolid,
to consider dosage reduction. Gastrointestinal compensated endocrine, renal or hepatic
should be about 20 - 25% of the dose previously being renal impairment, endocrine disease, chronic wide- clonidine, anticholinergics, tricylic
bleeding, development of duodenal ulcer, dark function, cardiac disorders, psychiatric diseases
taken angle glaucoma. Observe carefully when the dosage antidepressant, phenothiazines, phenytoin,
saliva, leukopenia, hemolytic and non-hemolytic or closed-angle glaucoma, undiagnosed skin
is reduced abruptly or discontinued, especially if the papaverine, selegiline and high protein diet
anaemia, thrombocytopenia, agranulocytosis, lesion, melanoma, pregnancy
patient is receiving neuroleptics. Pregnancy, women
angioedema, urticaria, pruritus, paraesthesia,
of childbearing potential. Not recommended in
increased libido, dyspnoea, alopecia, rash, dark
patients less than 18 years
sweat, dark urine

Open-angle glaucoma, depression, diabetes, severe
cardiovascular disease, bronchial asthma, renal,
Initial: 100/25 mg 1-2 times/day, increase every 3-4 dizziness, tachycardia, arrhythmias, reddish Hypersensitivity to this drug. Patient on MAOIs antagonism effect of antipsychotic, reduced
hepatic or endocrine disease, history of psychoses
days until therapeutic effect, optimal dosage: 400/100 discoloration of urine and other body fluid, rarely therapy with decompensated endocrine, renal or absorption by iron, plasma concentration
or convulsion. Lactation. Perform liver function and
Levodopa 100 mg, Benserazide 25 mg to 800/200 mg/day divided into 4-6 doses. Dose: hypersensitivity, abnormal involuntary hepatic function, cardiac disorders, psychiatric increased by metoclopramide. Tricylic
Madopar Parkinson's Disease blood count tests during treatment. Discontinue 12-
mg HBS capsule 200/50 mg used only when maintenance therapy is movement. Lost or change of taste. Abnormal diseases or closed-angle glaucoma. Pregnancy. antidepressant, phenothiazines, phenytoin,
48 hours before surgery requiring general
reached and not to exceed levodopa 1000-1200 involuntary movements. Rarely, skin reactions, Patients less than 25 years. Lactation. pyridoxine. Potentiates effects of
anaesthesia. If patient must undergo surgery without
mg/benserazide 250-300 mg per day haemolytic anaemia, mild, transient leukopenia Combination with MAOIs (except selegiline) sympathomimetics. Neuroleptics, opioids,
Madopar having been withdrawn, avoid anaesthesia
with cyclopropane or halothane
Nausea, diarrhea, abdominal pain, constipation,

vomiting, anorexia, gastrointestinal bleeding,
duodenal ulcer, dyspepsia, taste alterations,
heartburn, dyskinesia, orthostatic hypotension, Hypersensitivity to any component of the
Antihypertensive agents, MAO inhibitors, tricyclic
syncope, arrhythmia, chest pain, palpitation, product, concomitant use of nonselective MAOIs
Renal function periodically in chronic renal antidepressants, Dopamine D2 receptor
dizziness, fatigue, hallucinations, anxiety, (must be discontinued at least two weeks prior to
100 mg 3 - 4 times daily and subsequently titrated up to impairment including those receiving dialysis, mild to antagonists, papaverine, phenytoin, drugs known
Levodopa 100 mg, Carbidopa 25 mg somnolence, agitation, memory impairment, initiating therapy with Stalevo), severe hepatic
Stalevo® Idiopathic Parkinson's disease 150 mg 3 - 4 times daily as required. Maximum dose of moderate hepatic impairment, dose reduction may to interfere with biliary excretion, glucuronidation,
and Entacapone 200 mg Tablet EPS, disorientation, delusions, euphoria, impairment, narrow-angle glaucoma, patients
entacapone is 1600 mg/ day (8 tablet) be necessary, abrupt discontinuation/dose reduction and intestinal beta-glucuronidase, drugs
somnolence, confusion, nightmares, headache, with history of melanoma or suspicious,
of carbidopa/levodopa metabolized by COMT, iron salts,
purpura, rash, alopecia, malignant melanoma, undiagnosed skin lesions, history of neuroleptic
metoclopramide
urticaria, pruritus, urine discoloration, dyspnoea, malignant syndrome
increased libido, hemolytic anaemia,
agranulocytosis, thrombocytopenia, leukopenia,
decreased hemoglobin and hematocrit
Nausea, diarrhea, abdominal pain, constipation,

vomiting, anorexia, gastrointestinal bleeding,
duodenal ulcer, dyspepsia, taste alterations,
heartburn, dyskinesia, orthostatic hypotension, Hypersensitivity to any component of the
Antihypertensive agents, MAO inhibitors, tricyclic
syncope, arrhythmia, chest pain, palpitation, product, concomitant use of nonselective MAOIs
antidepressants, Dopamine D2 receptor
Renal function periodically in chronic renal dizziness, fatigue, hallucinations, anxiety, (must be discontinued at least two weeks prior to
100 mg 3 - 4 times daily and subsequently titrated up to antagonists, papaverine, phenytoin, drugs known
Levodopa 150 mg, Carbidopa 37.5 impairment including those receiving dialysis, mild to somnolence, agitation, memory impairment, initioating therapy with Stalevo), severe hepatic
Stalevo® Idiopathic Parkinson's disease 150 mg 3 - 4 times daily as required. Maximum dose of to interfere with biliary excretion, glucuronidation,
mg and Entacapone 200 mg Tablet moderate hepatic impairment, dose reduction may EPS, disorientation, delusions, euphoria, impairment, narrow-angle glaucoma, patients
entacapone is 1600 mg/ day (8 tablet) and intestinal beta-glucuronidase, drugs
be necessary, abrupt discontinuation/dose somnolence, confusion, nightmares, headache, with history of melanoma or suspicious,
metabolized by COMT, iron salts,
purpura, rash, alopecia, malignant melanoma, undiagnosed skin lesions, history of neuroleptic
metoclopramide
urticaria, pruritus, urine discoloration, dyspnoea, malignant syndrome
increased libido, haemolytic anemia,
agranulocytosis, thrombocytopenia, leukopenia,
decreased hemoglobin and hematocrit

Open-angle glaucoma, depression, diabetes, severe
cardiovascular disease, bronchial asthma, renal,
Initial: 100/25 mg 1-2 times/day, increase every 3-4 dizziness, tachycardia, arrhythmias, reddish Hypersensitivity to this drug. Patient on MAOIs antagonism effect of antipsychotic, reduced
hepatic or endocrine disease, history of psychoses
days until therapeutic effect, optimal dosage: 400/100 discoloration of urine and other body fluid, rarely therapy with decompensated endocrine, renal or absorption by iron, plasma concentration
or convulsion. Lactation. Perform liver function and
Levodopa 200 mg, Benserazide 50 mg to 800/200 mg/day divided into 4-6 doses. Dose: hypersensitivity, abnormal involuntary hepatic function, cardiac disorders, psychiatric increased by metoclopramide. Tricylic
Madopar Parkinson's Disease blood count tests during treatment. Discontinue 12-
mg Tablet 200/50 mg used only when maintenance therapy is movement. Lost or change of taste. Abnormal diseases or closed-angle glaucoma. Pregnancy. antidepressant, phenothiazines, phenytoin,
48 hours before surgery requiring general
reached and not to exceed levodopa 1000-1200 involuntary movements. Rarely, skin reactions, Patients less than 25 years. Lactation. pyridoxine. Potentiates effects of
anaesthesia. If patient must undergo surgery without
mg/benserazide 250-300 mg per day haemolytic anaemia, mild, transient leukopenia Combination with MAOIs (except selegiline) sympathomimetics. Neuroleptics, opioids,
Madopar having been withdrawn, avoid anaesthesia
with cyclopropane or halothane
Central nervous system: Anxiety, confusion,

Not recommended for treatment of drug-induced
nervousness, mental depression, psychotic
extrapyramidal reactions. The occurrence of
symptoms. Anorexia, nausea and vomiting,
dyskinesias in patients previously treated with
diarrhoea, insomnia, agitation, postural Hypersensitivity to this drug. Patient on MAOIs
levodopa alone may require dosage reduction. All Hypertensive crisis with MAOIs, increased
hypotension, dizziness, chest pain, tachycardia, therapy or 2 weeks prior to initiating therapy.
Patients not receiving Levodopa before, initially 100 - patients should be observed carefully for the hypotensive effect with antihypertensives,
arrhythmias, reddish discoloration of urine and May be administered concomitantly with or an
125 mg 3 - 4 times daily adjusted according to development of depression with concomitant suicidal antagonism effect of antipsychotic, reduced
other body fluid. Dyskinesia, muscle twitching MAOI with or selectivity for MAO type B (eg
Levodopa 250 mg and Carbidopa 25 response. Maintenance: 0.75 - 2 g in divided doses. In tendencies. Cardiovascular disease or pulmonary absorption by iron, plasma concentration
Sinemet Parkinson's disease and blepharospasm may be taken as early signs selegiline HCl). Narrow-angle glaucoma with
mg Tablet patients previously treated with Levodopa the dose disease, bronchial asthma. Hepatic impairment, increased by metoclopramide. Linezolid,
to consider dosage reduction. Gastrointestinal compensated endocrine, renal or hepatic
should be about 20 - 25% of the dose previous being renal impairment, endocrine disease, chronic wide- clonidine, anticholinergics, tricylic
bleeding, development of duodenal ulcer, dark function, cardiac disorders, psychiatric diseases
taken angle glaucoma. Observe carefully when the dosage antidepressant, phenothiazines, phenytoin,
saliva, leukopenia, hemolytic and non-hemolytic or closed-angle glaucoma, undiagnosed skin
is reduced abruptly or discontinued, especially if the papaverine, selegiline and high protein diet
anemia, thrombocytopenia, agranulocytosis, lesion, melanoma, pregnancy
patient is receiving neuroleptics. Pregnancy, women
angioedema, urticaria, pruritus, paresthesia,
of childbearing potential. Not recommended in
increased libido, dyspnea, alopecia, rash, dark
patients less than 18 years
sweat, dark urine
Antacids, sucralfate, divalent cations,
Renal impairment (CrCl less than 50 mL/minute),
multivitamin, theophylline, warfarin, NSAIDS,
CNS disorders, predisposition to seizures, lowered
antidiabetic agents, amiodarone,
convulsion threshold, diabetes mellitus, conditions
Diarrhoea, nausea, headache, blurred vision, Hypersensitivity to quinolones, pregnancy & chlorpromazine, cortisone, dexamethasone,
predisposing to torsade de pointes, significant
Levofloxacin 250 mg Tablet Loxof, Cravit Community acquired pneumonia 500 mg daily for 7 - 14 days hypoglycemia, tendinitis, anaphylactic reactions, lactation. Children and growing adolescents less diclofenac, disopyramide, ibuprofen,
bradycardia, cardiomyopathy, G6PD deficiency.
Stevens-Johnson syndrome than 18 years old indomethacin, iron, ketoprofen, ketorolac,
Ensure adequate hydration. Avoid excessive sun
mefenamic acid, meloxicam, naproxen,
exposure. May affect ability to drive or operate
phenylbutazone, piroxicam, prednisolone,
machinery
prochlorperazine, quinidine
Levofloxacin 500 mg Injection Loxof, Cravit Community Acquired Pneumonia 500 mg daily for 7 - 14 days hypoglycemia, tendinitis, anaphylactic reactions, lactation. Children and growing adolescents less diclofenac, disopyramide, ibuprofen,
machinery
Levofloxacin 500 mg Tablet Loxof, Cravit Community acquired pneumonia 500 mg daily for 7 - 14 days hypoglycemia, tendinitis, anaphylactic reactions, lactation. Children and growing adolescents less diclofenac, disopyramide, ibuprofen,
machinery
Acne, weight gain, abdominal pain, nausea,
Effectiveness is reduced by enzyme inducing
Emergency contraception within 72 hours of 1.5 mg as a single dose as soon as possible after Not effective in terminating an existing pregnancy, dizziness, headache, depression, breast
drugs such as barbiturates, phenytoin,
Levonorgestrel 1.5 mg Tablet Escapelle unprotected sexual intercourse for the female victim of coitus [preferably within 12 hours but no later than after not recommended for routine use as a contraceptive tenderness, cyst of ovary, fatigue pelvic Genital bleeding of unknown etiology, pregnancy
carbamazepine, St. John's Wort, rifampicin,
sexual violence to prevent unwanted pregnancy 72 hours] and in patients with severe hepatic dysfunction inflammatory disease, sepsis, menstrual
ritonavir and griseofulvin
irregularities
Age, smoking, gall bladder disease, diabetes, Thromboembolic disorders, cardiovascular
hypertension, epilepsy, migraine, cardiac or renal disease, breast or endometrial cancer, oestrogen
Effectiveness may be reduced by antibiotics,
Levonorgestrel 150 mcg and 1 tablet daily for 21 days from first day of the cycle, dysfunction, history of depression, uterine fibroids, Thromboembolic disease, hypertension, gall dependent neoplasia, undiagnosed abnormal
Rigevidon Contraception phenytoin, carbamazepine, barbiturates,
Ethinyloestradiol 30 mcg Tablet followed by 7 tab free days lactation. Gastrointestinal disease (impaired bladder disease, nausea, vomiting, migraine vaginal bleeding, cholestatic jaundice of
rifampicin
absorption of oral contraceptive steroids in the small pregnancy, hepatic adenomas or carcinomas,
bowel due to inflammatory disease) known or suspected pregnancy
Discontinue treatment if crescendo migraine or other
symptoms indicating transient cerebral ischaemia,
exceptionally severe headache, jaundice, marked
Menstrual changes, lower abdominal pain, acne
increase of blood pressure, unexplained loss of Active hepatic disease, active thrombophlebitis
or other skin problems, backpain, mastalgia,
One unit intrauterine device to be inserted into the vision or other symptoms of retinal thrombosis or thromboembolic disorders, haemorrhagic
headache, vaginal discharge, mood changes,
uterine cavity within 7 days of the onset of menstruation occurs. Hormone dependent neoplasia including diathesis, carcinoma of the breast, pregnancy,
Levonorgestrel Releasing Intrauterine nausea, oedema, weight gain, decreased libido,
Mirena Contraception (Initial release rate of 20 mcg/24 hours) or immediately after first trimester abortion. Postpartum breast cancer, malignancies affecting the blood or undiagnosed abnormal uterine bleeding, Not known
System sweating, hair loss, greasy hair, ectopic
insertion should be postponed until 6 weeks after leukaemias, severe arterial disease eg stroke or undiagnosed abnormal genital bleeding, history
pregnancy, pelvic inflammatory disease (PID),
delivery. One unit IUD is effective for 5 years myocardia infarction. Diabetics. In recurrent of idiopathic intracranial hypertension,
perforation of uterine wall, enlarged follicles may
endometriosis, pelvic infections or if an acute hypersensitivity
develop
infection does not respond to treatment within a few
days, perforation, accidental pregnancy. Not a
contraceptive of choice during lactation
Reduced absorption with iron, cholestyramine,
colestipol, aluminium- and magnesium-
containing antacids, calcium carbonate,
Nervousness, excitability, tremor, muscle simethicone, sucralfate. May alter requirements
ADULT: 1.7 mcg/kg/day orally in a single daily dose weakness, cramps, sweating, flushing, heat of antidiabetic drugs. Reduced efficacy of thyroid
Angina, heart failure, diabetes mellitus, diabetes
(usual maintenance dose is 100 - 125 mcg/day 70 kg intolerance, headache, insomnia, tachycardia, replacement therapy with imatinib. Reduced tri-
insipidus, elderly, long-standing hypothyroidism,
Levothyroxine Sodium 100 mcg adult). CHILD; 0 - 3 months: 10 - 15 mcg/kg/day; 3 - 6 palpitations, angina pectoris, excessive weight Untreated hyperthyroidism; uncorrected adrenal iodothyronine serum levels with amiodarone.
Oroxine Hypothyroidism adrenal insufficiency, myxoedema. Do not use for
Tablet months: 8 - 10 mcg/kg/day; 6 - 12 months: 6 - 8 loss, menstrual irregularities, diarrhoea, vomiting, failure; recent myocardial infarction Reduced serum levels of thyroxine with
treatment of obesity or for weight loss. Pregnancy,
mcg/kg/day; 1 - 5 years: 5 - 6 mcg/kg/day; 6 - 12 years: convulsions, cardiac arrhythmia, heart failure, carbamazepine, phenytoin, phenobarbital,
lactation
4 - 5 mcg/kg/day; more than 12 years: 2 -3 mcg/kg/day coma, myocardial infarction, osteopenia, rifampicin, oestrogens. May change
pseudotumor cerebri, seizure hypoprothrombinaemic response to warfarin and
other oral anticoagulants. Increased risk of
significant hypertension and tachycardia with
ketamine
Reduced absorption with iron, colestyramine,
ADULT:1.7 mcg/kg/day ORALLY in a single daily dose weakness, cramps; sweating, flushing, heat of antidiabetic drugs. Reduced efficacy of thyroid
Angina, heart failure; diabetes mellitus; diabetes
(usual maintenance dose is 100-125 mcg/day 70 kg intolerance, headache, insomnia, tachycardia, replacement therapy with imatinib. Reduced tri-
insipidus; elderly; long-standing hypothyroidism;
adult) CHILD; 0-3 months: 10-15 mcg/kg/day; 3-6 palpitations, angina pectoris, excessive weight Untreated hyperthyroidism; uncorrected adrenal iodothyronine serum levels with amiodarone.
Levothyroxine Sodium 25 mcg Tablet Hypothyroidism adrenal insufficiency; myxoedema. Do not use for
months: 8-10 mcg/kg/day; 6-12 months: 6-8 loss; menstrual irregularities; diarrhoea, vomiting, failure; recent myocardial infarction Reduced serum levels of thyroxine with
mcg/kg/day; 1-5 years: 5-6 mcg/kg/day; 6-12 years: 4-5 convulsions, cardiac arrhythmia, heart failure, carbamazepine, phenytoin, phenobarbital,
lactation
mcg/kg/day; more than 12 years: 2-3 mcg/kg/day coma,myocardial infarction, osteopenia, rifampicin, oestrogens. May change
ketamine
Reduced absorption with iron, cholestyramine,
ADULT: 1.7 mcg/kg/day orally in a single daily dose weakness, cramps, sweating, flushing, heat of antidiabetic drugs. Reduced efficacy of thyroid
Angina, heart failure, diabetes mellitus, diabetes
(usual maintenance dose is 100 - 125 mcg/day 70 kg intolerance, headache, insomnia, tachycardia, replacement therapy with imatinib. Reduced tri-
insipidus, elderly, long-standing hypothyroidism,
adult). CHILD; 0 - 3 months: 10 - 15 mcg/kg/day; 3 - 6 palpitations, angina pectoris, excessive weight Untreated hyperthyroidism; uncorrected adrenal iodothyronine serum levels with amiodarone.
Levothyroxine Sodium 50 mcg Tablet Hypothyroidism adrenal insufficiency, myxoedema. Do not use for
months: 8 - 10 mcg/kg/day; 6 - 12 months: 6 - 8 loss, menstrual irregularities, diarrhoea, vomiting, failure; recent myocardial infarction Reduced serum levels of thyroxine with
mcg/kg/day; 1 - 5 years: 5 - 6 mcg/kg/day; 6 - 12 years: convulsions, cardiac arrhythmia, heart failure, carbamazepine, phenytoin, phenobarbital,
lactation
4 - 5 mcg/kg/day; more than 12 years: 2 -3 mcg/kg/day coma, myocardial infarction, osteopenia, rifampicin, oestrogens. May change
ketamine
Congenital or idiopathic methaemoglobinaemia,
Used for painless venepunctures, radial artery avoid in infant less than 6 months old. Open
Oedema, itching and exanthema allergic Potentiation of cardiac effects, antiarrhythmias;
cannulations before extradural/spinal and other wounds other than leg ulcers. Genital mucosa of
Lidocaine 25mg and Prilocaine 25mg Apply a thick layer under occlusive dressing at least 1 Not for use on wounds or mucous membrane, atopic reactions, increase methaemoglobin level. other local anaesthetics. Increased risk of
Emla regional blocks in children above 1 year old and adults. children. Impaired tympanic membrane. Prior to
Cream hour before the procedure dermatitis. Application in vicinity of the eyes Paleness, erythema (redness). Mild burning systemic toxicity in patients receiving other local
Also used in chronic renal failure patients for insertion intracutaneous injection of a live vaccine eg
sensation, itch or warmth in leg ulcer anaesth. Sulfonamides
of A-V fistulas and shunts for haemodialysis. BCG, infants less or 12 month, preterm infants
with gestational age less than 37 week
Potentiation of cardiac effects antiarrhythmias.
Lidocaine should be used with caution with
Cardiovascular disease, wounds or traumatised Circumoral paraesthesia, numbness of the dental injection anaesthesia, other local
mucosa in the application region. Partial or complete tongue, light headedness, tinnitus, severe anaesthetics or class intrabursal (IB)
For surface anaesthesia in dental practice, in heart block, elderly and patients in poor general hypotension, bradycardia, arrhythmia, Hypersensitivity to lidocaine or amide type of antiarrhythmic drugs, as the toxic effects are
Lignocaine 10 % w/w Spray Spray to affected part
otorhinolaryngology and paracentesis health. Advanced liver disease or severe renal cardiovascular collapse. Sore throat, local anaesthetics additive. Tocainide and drugs that reduce the
dysfunction. Avoid contact with eyes, wound or hoarseness, loss of voice, allergic reactions clearance of lidocaine (eg, cimetidine or β-
traumatised mucosa (rare) blockers) may cause potentially toxic plasma
concentrations when lidocaine is given in
repeated high doses over a long time period
Lignocaine 2 % with Adrenaline Xylocaine with For local anaesthesia including infiltration, nerve and By infiltration: 0.5 - 1 ml; not to exceed 7 mg/kg body Severe hypertension, arteriosclerotic heart disease Nervousness, dizziness, sedation, blurred vision, Thyrotoxicosis, region with compromised blood Potentiation of cardiac effects antiarrhythmias,
(1:80,000) Injection Adrenaline plexus blocks weight cerebrovascular insufficiency, heart block tinnitus, gastrointestinal effects supply tricyclic antidepressants
Traumatised mucosa and sepsis in the region of Allergic reactions. Intoxication, cutaneous and
application, chronic heart failure, bradycardia or hypersensitivity symptoms. Sore throat. Central
respiratory depression, hepatic insufficiency. Should nervous system excitation followed by
Use for endotracheal tubes and instruments, painful
not be used as ophthalmic drug. Presence of sepsis depression with drowsiness, respiratory failure
procedures in the ear, nose and throat, burns, wounds, Hypersensitivity to lidocaine or amide type of
Apply to affected area 10 mins before catheterization, or severely traumatized mucosa in area of and coma, numbness of tongue and perioral Potentiation of cardiac effects antiarrhythmias.
Lignocaine 2% Jelly Xylocaine abrasions, lacerations; catheterisation of the male and local anaesthetics. Hypovolaemia, heart block or
etc application. When used for endotracheal tube region, myocardial depression, peripheral Drugs structurally related to local anaesthesia
female urethra and for symptomatic treatment of cystitis other conduction disturbances
lubrication, avoid introducing into the lumen of the vasodilation, hypotension, bradycardia,
and urethritis
tube. Closely supervise patients being treated with arrhythmia, cardiac arrest. Prolonged use in the
class III antiarrhythmic drugs eg amiodarone and eye may lead to severe contact keratitis and
monitor ECG due to the additive effects corneal damage
Traumatised mucosa and sepsis, minimum interval
For post-tonsilectomy, sore throat, dumping syndrome, between doses: 3 hours. Monitoring should be Potentiation of cardiac effects, antiarrhythmias.
Intoxication, hypersensitivity, drowsiness,
hiccough, reflux vomiting, painful lesions of the mouth, considered with amiodarone. Partial or complete Hypersensitivity to lidocaine or amide type of Dental injection anaesthesia, other local
Lignocaine 2% Viscous Solution Xylocaine To be taken orally as directed excitement, dizziness, nausea, vomiting, blurred
cardiospasm, instrumentation of the respiratory and heart block, elderly and patients in poor general local anaesthetics anaesthesia or class intrabursal (IB)
vision. Allergic reactions (rare)
digestive tract health. Advanced liver disease or severe renal antiarrhythmic drugs
dysfunction
Severe hypertension, severe cardiac insufficiency,
To provide local anaesthesia and lubrication during arteriosclerotic heart disease, cerebrovascular
catheterization, exploration by sound and other insufficiency, heart block, seriously impaired hepatic Nervousness, dizziness, sedation, blurred vision, Potentiation of cardiac effects, antiarrhythmic
Lignocaine 2% with Chlorhexidine Xylocaine with Hypersensitivity to lidocaine or amide type of
endourethral operations and examinations, cytoscopy 6-11 ml into urethra and renal function, traumatized mucosa and or tinnitus, gastrointestinal effects. Rarely: allergic drugs, β-receptor-blocking agents, calcium
0.05% Gel Chlorhexidine local anaesthetics. Severe bradycardia
and symptomatic treatment of painful cystitis and inflammation/sepsis in the region of the proposed reactions channel antagonists
urethritis application and in patients with tendency to
convulsions
For anaesthesia of mucous membranes of the Bronchoscopy, 2 - 3 ml with suitable spray; biopsy in Perioral numbness, tinnitus, hypersensitivity,
Traumatised mucosa and sepsis, minimum interval Hypersensitivity to lidocaine or amide type of
Lignocaine 4 % Solution Xylocaine oropharyngeal, tracheal and bronchial areas eg. in mouth, 3 - 4 ml with suitable spray or swab (with drowsiness, excitement, dizziness, nausea, Potentiation of cardiac effects, antiarrhythmias
between doses: 3 hours local anaesthetics
laryngoscopy and bronchoscopy adrenaline if necessary); maximum 7.5 ml vomiting, blurred vision, arrhythmias
Beta-adrenergic blockers; increased lidocaine
Adams-Stokes syndrome, advanced heart failure. levels.Cimetidine;decreased lidocaine level.
EKG monitoring for intravenous administration. Class I antiarrhythmic agents (eg, tocainide,
Epidural anaesthesia; a test dose is recommended, mexiletine);toxic effects are additive and
Hypersensitivity to amide local anesthetics,
heart block, hepatic disease, hypovolaemia, renal Nervousness, dizziness, paraesthesia, potentially synergistic. Procainamide; additive
50-100 mg IV as a bolus, repeated after 5 minutes if Stokes-Adams syndrome, Wolff-Parkinson-White
Lignocaine HCl (Lidocaine) 100 mg/5 Ventricular tachycardia and ventricullar fibrillation. To disease, severe degrees of sinoatrial, drowsiness, tinnitus, disorientation, blurred neurological and cardiac effects.
Xylocard necessary. Maintenance : 1-4 mg/min by IV infusion syndrome,severe degrees of sinoatrial, AV or
ml Injection be diluted before use atrioventricular or intraventricular block. Shock, vision, tremor, convulsions, respiratory Succinylcholine;prolongation of neuromuscular
under ECG monitoring intraventricular block in absence of pacemaker,
sinus bradycardia, spinal anaesthesia, severe depression, hypotension, bradycardia blockade. Incompatibility with; amphotericin B,
ophthalmic use
haemorrhage, shock, heart block, local infection at parenteral cephalosporins, doxycycline,
injection site, septicaemia. Wolff-Parkinson-White epinephrine, isoprenaline, methohexital,
syndrome nitroprusside, norepinephrine, phenytoin, sodium
bicarbonate, sulfadiazine
Nervousness, dizziness, sedation, blurred vision,
tinnitus, gastrointestinal effects, dose-related
methaemoglobinaemia and cyanosis.
Local anesthesia : ADULT Maximum: 200 mg; CHILD
Neurological disorder, severe bradycardia, cardiac Restlessness, excitement, nervousness,
Local anesth by infiltration IV regional anesthesia and Maximum: 30 mg/kg Cardiac arrhythmias : ADULT 50- Local inflammation and/or sepsis, septicaemia.
conduction abnormalities, pregnancy, congestive paraesthesia, vomiting, muscle twitching and
Lignocaine HCl (Lidocaine) 2% nerve block. Emergency management of ventricular 100 mg IV. Maximum: 200-300 mg/hour; CHILD Hypovolaemia, heart block and other conduction Potentiation of cardiac effects antiarrhythmias,
Xylocaine heart failure, respiratory depression, hepatic or renal tremors, convulsions. Numbness of tongue and
Injection arrhythmias particularly after myocardial infarction and Loading dose: 0.8-1 mg/kg IV repeated if necessary up disturbances, bradycardia, cardiac phenytoin, beta-blockers, cimetidine
insufficiency, epilepsy, shock, myasthenia gravis. perioral region, light headedness, sedation, CNS
cardiac surgery to 3-5 mg/kg followed by a continuous infusion of 10-50 decompensation or hypotension
Elderly. Pregnancy and lactation depression, respiratory failure and coma.
mcg/kg/min
Arrhythmias, bradycardia, cardiac arrest,
anaphylaxis. Lassitude, amnesia, foetal
intoxication
Beta-adrenergic blockers; increased lidocaine
Adams-Stokes syndrome, advanced heart failure. levels.Cimetidine;decreased lidocaine level.
EKG monitoring for intravenous administration. Class I antiarrhythmic agents (eg, tocainide,
Epidural anaesthesia; a test dose is recommended, mexiletine);toxic effects are additive and
Hypersensitivity to amide local anesthetics,
heart block, hepatic disease, hypovolaemia, renal Nervousness, dizziness, paraesthesia, potentially synergistic. Procainamide; additive
50-100 mg IV as a bolus, repeated after 5 minutes if Stokes-Adams syndrome, Wolff-Parkinson-White
Lignocaine HCl (Lidocaine) 500 mg/5 Ventricular tachycardia and ventricullar fibrillation. To disease, severe degrees of sinoatrial, drowsiness, tinnitus, disorientation, blurred neurological and cardiac effects.
Xylocard necessary. Maintenance : 1-4 mg/min by IV infusion syndrome,severe degrees of sinoatrial, AV or
ml Injection be diluted before use atrioventricular or intraventricular block. Shock, vision, tremor, convulsions, respiratory Succinylcholine;prolongation of neuromuscular
under ECG monitoring intraventricular block in absence of pacemaker,
sinus bradycardia, spinal anaesthesia, severe depression, hypotension, bradycardia blockade. Incompatibility with; amphotericin B,
ophthalmic use
haemorrhage, shock, heart block, local infection at parenteral cephalosporins, doxycycline,
injection site, septicaemia. Wolff-Parkinson-White epinephrine, isoprenaline, methohexital,
syndrome nitroprusside, norepinephrine, phenytoin, sodium
bicarbonate, sulfadiazine
Restlessness, excitement, nervousness,
paraesthesia, dizziness, blurred vision, nausea,
According to patients weight and nature of procedures, vomiting, muscle twitching and tremors,
maximum 200mg. For most obstetric procedures, the Chronic heart failure, respiratory depression, hepatic convulsions. Numbness of tongue and perioral Hypovolaemia, heart block and other conduction
Lignocaine HCl 1% Injection Lakan Local or regional anaesthesia for episiotomy repairs preparation is diluted to 0.5%, which gives the or renal insufficiency, epilepsy, shock, myasthenia region, lightheadedness, sedation, central disturbances, bradycardia, cardiac Other antiarrhythmics, β-blockers, cimetidine
maximum effect with the least toxicity. [lignocaine 1%, 1 gravis. Elderly. Pregnancy and lactation nervous system depression, respiratory failure decompensation or hypotension
part and normal saline or sterile distilled water, 1 part] and coma. Arrhythmias, bradycardia, cardiac
arrest, anaphylaxis. Lassitude, amnesia.
Methaemoglobinaemia, foetal intoxication
Children less than 12 years, traumatised mucosa, With large doses of lidocaine, risk of additional
Lignocaine, Aluminium Acetate, Zinc Dry skin, pruritus, irritation, transient Hypersensitivity to local anaesthetics or to other
Xyloproct Anorectal pain, pruritis, inflammation and irritation Apply once or twice daily. Not for prolonged use sepsis in anorectal region or suspected herpes systemic toxicity in patients receiving other local
Oxide and Hydrocortisone Ointment burning/stinging and atrophy of anal skin components of the product
simplex infection anaesthetics
Lignocaine, Aluminium Acetate, Zinc Children less than 12 years old, traumatised With large doses of lidocaine, risk of additional
1 suppository to be used once or twice daily. Not for Dry skin, pruritus, irritation, transient Hypersensitivity to local anaesthetics or to other
Oxide and Hydrocortisone Xyloproct Anorectal pain, pruritis, inflammation and irritation mucosa, sepsis in anorectal region or suspected systemic toxicity in patients receiving other local
prolonged use burning/stinging and atrophy of anal skin components of the product
Suppository herpes simplex infection anaesthetics
Monitor Full Blood Count (FBC) in patients with pre-
Headache, insomnia, thrombocytopenia,
existing myelosuppression, increased bleeding risk
ADULT: 600 mg twice daily for 10 - 14 days. CHILD: 10 myelosuppression, optic nerve disorder, Citalopram, dopamine, epinephrine,
MRSA patient with severe sepsis requiring intensive or who receive medications that may decrease
Linezolid 2 mg/ml Injection Zyvox mg/kg 3 times daily. PREMATURE NEONATES less peripheral neuropathy, diarrhoea, nausea, Hypersensitivity to linezolid escitalopram, fluoxetine, fluvoxamine, sertraline,
care and not clinically responding to vancomycin haemoglobin levels, platelet count or function, or
than 7 days: 10 mg/kg twice daily myelosuppression, vomiting, constipation, rash, venlafaxine, pseudoephedrine, tramadol
who received linezolid for more than 2 weeks.
dizziness, fever
Pregnancy
Monitor full blood count (FBC) in patients with pre- Headache, insomnia, thrombocytopenia,
existing myelosuppression, increased bleeding risk myelosuppression, optic nerve disorder, Citalopram, dopamine, epinephrine,
MRSA patients with severe sepsis requiring intensive CHILD: 10 mg/kg 3 times daily. PREMATURE
Linezolid 20 mg/ml Suspension Zyvox or who receive medications that may decrease peripheral neuropathy, diarrhoea, nausea, Hypersensitivity to linezolid escitalopram, fluoxetine, fluvoxamine, sertraline,
care and not clinically responding to vancomycin NEONATES less than 7 days: 10 mg/kg twice daily
haemoglobin levels, platelet count or function or who myelosuppression, vomiting, constipation, rash, venlafaxine, pseudoephedrine, tramadol
received linezolid for more than 2 weeks. Pregnancy dizziness, fever
Monitor FBC in patients with pre-existing Headache, insomnia, thrombocytopaenia,
ADULT: 600 mg twice daily for 10-14 days. CHILD :10 myelosuppression, increased bleeding risk or who myelosuppression, optic and peripheral Citalopram, dopamine, epinephrine,
MRSA patient with severe sepsis requiring intensive
Linezolid 600 mg Tablet Zyvox mg/kg 3 times daily. PREMATURE NEONATES less receive medications that may decrease haemoglobin neuropathy.diarrhea , nausea, Hypersensitivity to linezolid escitalopram, fluoxetine, fluvoxamine, sertraline,
care and not clinically responding to vancomycin.
than 7 days: 10 mg/kg twice daily levels, platelet count or who received linezolid for myelosuppression, vomiting, constipation, rash, venlafaxine, pseudoephedrine, tramadol
more than 2 weeks dizziness, fever
Anal seepage of paraffin and consequent anal
irritation after prolonged use, granulomatous
ADULT 10-30 ml daily at night but should not be taken Avoid prolong use, patients with with recent change Nausea, vomiting, undiagnosed abdominal pain,
reactions caused by absorption of small
Liquid Paraffin - Constipation immediately before going to bed. CHILD not of bowel habits or suspected bowel malignancy and pregnancy, difficulty swallowing, bedridden May impair the absorption of fat soluble vitamin
quantities of liquid paraffin, lipoid pneumonia and
recommended rectal bleeding patients, children less than 3 years
interference with the absorption of fat soluble
vitamins
Cardiovascular insufficiency, elderly, electrolyte
Gastrointestinal effect, vertigo, dazed feeling,
imbalance, current infection, impaired renal function, Diuretics, steroids, haloperidol, fluphentixol,
fine hand tremor, polyuria, drowsiness, muscle
volume depletion, thyroid disorder, CAD, diazepam, methyldopa, tetracyclines, phenytoin,
i) Prophylaxis and treatment of acute mania and weakness, anorexia, dry mouth, fatigue, Renal insufficiency, Addison's disease, untreated
1800 mg/day in 2-3 divided doses, desired serum myasthaenia gravis, pregnancy and lactation. carbamazepine, Lithium toxicity with ACE
hypomania episodes ii)Prophylaxis of manic seizures, leucocytosis, goitre, coma. hypothyrodism, lactation, delibated or
Lithium Carbonate 300 mg Tablet - lithium level ranging between 0.4-1 mmol/litre. Monitor serum levels cardiac, renal and thyroid inhibitors, caffeine, COX2 inhibitors,
depression in bipolar illness or bipolar depression and Exacerbation of psoriasis, acne, rash, nausea, dehydrated patient, pregnancy, disturbed
Maintenance 900-1200 mg/day in 2-3 divided doses function regularly. Maintain adequate fluid intake. metronidazole, non-depolarising neuromuscular
recurrent depression diarrhoea, vertigo,loss of concentration, tremors, electrolyte balance, major surgery
Avoid alcohol. May impair ability to perform skilled blockers, NSAIDs, potassium iodide, SSRIs,
hypothyroidism, weight gain, cardiac
tasks. Discontinue temporarily 24 hours prior to tricyclic antidepressants
arrhythmias; exophthalmos, restlessness
major surgery
Acute diarrhoea: ADULT: 4 mg stat, followed by 2 mg
Hepatic dysfunction, acute dysentery, acute Abdominal pain, constipation, nausea, vomiting,
after each unformed stool (up to 5 days). Usual 6- 8 mg
Adjunct to rehydration in acute diarrhoea in adult also ulcerative colitis with abdominal distension toxic megacolon, dry mouth, drowsiness, Children lessthan 2 years of age, hypersentivity Increased risk of severe constipation when used
Loperamide 2 mg Capsule Imodium daily. Max: 16 mg daily. Chronic diarrhoea: Initially 4-8
in chronic diarrhoea in adult (discontinue use), children under 6 years, lactation dizziness, fatigue, skin reactions, abdominal to the drug. Infective or antibiotic induced colitis with opioid analgesics
mg daily in divided doses, adjust according to
and pregnancy bloating
response. Max: 16 mg daily
Antiarrhythmias, anticonvulsant, antihistamines,
Dyslipidemia, hyperglycaemia, Hypersensitivity to lopinavir or ritonavir,
Lopinavir 200 mg and Ritonavir 50 mg As second line protease inhibitor if intolerant to ADULT and CHILD with BSA greater than 1.4 m2 or Hepatic impairment, renal impairment, haemophilia, benzodiazepines, calcium channel blockers,
Kaletra hypercholesterolemia, increased triglycerides, concomitant use with drugs that are highly
Tablet indinavir/ ritonavir as part of HAART regimen body weight 40kg and over: 2 tablets twice daily pregnancy, diabetes, pancreatitis cisapride, clarithromycin, dexamethasone,
diarrhoea, nausea, headache, pain, insomnia dependent on CYP3A or CYP2D6 for clearance
disulfiram, didanosine
12 mg/kg twice daily for those 7 - 15 kg and 10mg/kg Antiarrhythmias, anticonvulsant, antihistamines,
Management of patients with asymptomatic and Dyslipidaemia, hyperglycaemia, Hypersensitivity to lopinavir or ritonavir,
twice daily for those 15 - 40 kg taken with food, up to a Hepatic impaiment, renal impairment, haemophilia, benzodiazepines, calcium channel blockers,
Lopinavir/Ritonavir Oral Solution Kaletra symptomatic (early or advanced) HIV Infection with hypercholesterolemia, increased triglycerides, concomitant use with drugs that are highly
maximum dose of 533 mg Lopinavir/13.3mg Ritonavir in pregnancy, diabetes, pancreatitis cisapride, clarithromycin, dexamethasone,
CD4 cell counts diarrhoea, nausea, headache, pain, insomnia dependent on CYP3A or CYP2D6 for clearance
children greater than 45 kg (5 ml) twice daily disulfiram, didanosine
Impaired liver and renal function (use lower dose).
Allergic rhinitis, chronic urticaria and other allergic ADULT and CHILD over 6 years : 10 mg once daily. Cimetidine, erythromycin, ketoconazole and
Loratadine 1 mg/ml Syrup Clarityne Should not take with alcohol and avoid operating Headache, nervousness, sedation Hypersensitivity to loratadine
dermatological disorders CHILD 2 - 6 years: 5 mg once daily other hepatic enzyme inhibitors
vehicle and machinery
Impaired liver and renal function (use lower dose).
ADULT and CHILD over 6 years 10 mg once daily. Cimetidine, erythromycin, ketoconazole and
Loratadine 10 mg Tablet Clarityne Allergic rhinitis and allergic dermatoses Should not take with alcohol and avoid operating Headache, sedation, nervousness Hypersensitivity to loratadine
CHILD 2 - 6 years: 5 mg once daily other hepatic enzyme inhibitors
vehicle and machinery
Narrow-angle glaucoma, urinary retention, Loratadine is metabolised by cytochrome P450
Avoid in hepatic insufficiency, renal insufficiency
severe coronary artery disease, severe isoenzymes CYP3A4 and CYP2D6. Therefore
(use lower initial dose), pregnancy, hypertension, Headache, nervousness, dizziness, tachycardia,
Loratadine 5 mg and hypertension, concomitant therapy with MAOIs concomitant administration of other drugs that
diabetes mellitus, ischaemic heart disease, rhinitis, pruritis, acne, insomnia, fatigue,
Pseudoephedrine Sulphate 120 mg Clarinase For treatment of allergic rhinitis and allergic dermatoses ADULT and CHILD over 12 years 1 tablet twice daily or within 10 days of continuing such treatment, inhibit or are metabolised by these hepatic
increased intraocular pressure, hyperthyroidism, pharyngitis, somnolence, nausea, palpitations,
Tablet hyperthyroidism, hepatic and renal impairment, enzymes may result in changes in plasma
prostatic hypertrophy, stenosing peptic ulcer, elderly, tachycardia
hypersensitivity to loratadine or concentrations of either drug, bromocriptine,
lactating, prostatic hypertrophy
pseudoephedrine hydrocodone, selegiline
Concomitant use of central nervous system drugs Theophylline, decreased benzodiazepine
such as phenothiazines, narcotic analgesics, effectiveness. Valproic acid, increased
Respiratory depression, acute pulmonary
barbiturates, antidepressants, scopolamine and Fatigue, hypotension, ataxia, respiratory lorazepam concentrations. Clozapine, alcohol or
insufficiency, sleep apnoea syndrome, severe
i) 1 - 4 mg increase to 10 mg daily in divided doses. MAOIs; elderly and debilitated patients, patients with depression, sedation, confusion, depression, central nervous system depressants, will give
hepatic impairment, myasthenia gravis, phobic or
Lorazepam 1 mg Tablet Ativan i) Severe anxiety ii) Insomnia ELDERLY (or delibitated) half adult dose ii) 1 - 2 mg at a limited pulmonary reserve, doses exceeding 2 headache, nausea, tremor, urinary retention, additive central nervous system depression
obsessional states, depression or anxiety with
bedtime Not recommended in children mg/day in geriatric patients or debilitated patients, vertigo, withdrawal syndrome, bradycardia, effect. Contraceptive, decreased lorazepam
depression, acute narrow-angle glaucoma,
not recommended in patients with primary dependence or abuse effect. Rifampicin, decreased effect of
hypersensitivity to benzodiazepines
depressive disorder or psychosis. Potential for drug lorazepam. Digoxin, increased serum digoxin
abuse, impaired liver/renal function concentrations
Angioedema: intravascular volume depletion (eg

Hypertension: Usual starting and maintenance dose: 50
those treated with high-dose diuretics), electrolyte
mg once daily. Maximum increasing the dose to 100 mg
imbalance: lower dose should be considered for
Patients intolerant of ACE inhibitors, only in the once daily. Patients with intravascular volume-depletion
patients with a history of hepatic impairment,
treatment of i) Hypertensive patient with left ventricular starting dose of 25 mg once daily. Renal protection in
Losartan 50 mg Tablet Cozaar changes in renal function including renal failure may Angioedema, headache, dizziness, cough Hypersensitivity to losartan, pregnancy Fluconazole, lithium, rifampicin
hypertrophy ii) Hypertension in diabetics with Type 2 diabetic patients with proteinuria and
occur in susceptible individuals. Blood urea and
proteinuria or nephropathy hypertension, starting dose: 50 mg once daily, may be
serum creatinine may be increased in patients with
increased to 100 mg once daily based on blood
bilateral renal artery stenosis or stenosis of the
pressure response
artery to a solitary kidney, lactation, children
Angioedema. Not recommended for hepatic
impairment or severe renal impairment (creatinine
clearance less or equal to 30 mL/min). Changes in
renal function including renal failure may occur.
Bilateral renal artery stenosis or stenosis of the
Dizziness, asthenia and fatigue, vertigo.
artery to a solitary kidney. Hypotension and Angiotensin converting enzyme inhibitors,
Anaphylactic reactions, angioedema, vasculitis Hypersensitivity including to other sulfonamide-
electrolyte or fluid imbalance may occur. Thiazide calcitriol, chlorpropamide, cholestyramine,
including Henoch-Schonlein purpura, hepatitis, derived drugs, anuria. When used during second
Hypertension in patients who cannot tolerate ACE therapy may impair glucose tolerance, decrease corticotropin, cortisone, diazoxide, digitalis
Losartan Potassium 100 mg and 1 tablet once daily, may increase to maximum dose diarrhoea, cough, urticaria, erythroderma, and third trimesters, drugs that act directly on the
Hyzaar inhibitors because of cough, hypertensive patient with urinary calcium excretion, intermittent and slight glycosides, diuretics, droperidol, hydrocortisone,
Hydrochlorothiazide 12.5 mg Tablet losartan 100 mg/ hydrochlorothiazide 25 mg once daily oedema, palpitations, headache, electrolyte renin-angiotensin system can cause foetal injury
left ventricular hypertrophy increases in serum calcium may occur, increase indomethacin, liquorice, lithium, methotrexate,
abnormalities, abdominal pain, nausea, and death. Discontinue as soon as possible if
cholesterol and triglyceride levels, precipitate with or methylprednisolone, prednisolone, propranolol,
bronchitis, pharyngitis, sinusitis, upper pregnancy is detected
without a history of allergy or bronchial asthma. tolbutamide, triamcinolone
respiratory infection, skin rash, back pain
Thiazides have also been reported to exacerbate or
activate systemic lupus erythematosus. Should not
be initiated in patients with intravascular volume
depletion (eg those treated with high dose diuretics),
black patients,Not
Angioedema. lactation, children for hepatic
recommended
impairment or severe renal impairment (creatinine
clearance less than 30 mL/min). Changes in renal
function including renal failure may occur. Bilateral
renal artery stenosis or stenosis of the artery to a
Dizziness, asthenia and fatigue, vertigo.
solitary kidney. Hypotension and electrolyte or fluid Angiotensin converting enzyme inhibitors,
Anaphylactic reactions, angioedema, vasculitis Hypersensitivity including to other sulfonamide-
imbalance may occur. Thiazide therapy may impair calcitriol, chlorpropamide, cholestyramine,
including Henoch-Schonlein purpura, hepatitis, derived drugs, anuria. When used during second
Hypertension in patients who cannot tolerate ACE glucose tolerance, decrease urinary calcium corticotropin, cortisone, diazoxide, digitalis
Losartan Potassium 50 mg and 1 tablet once daily, may increase to maximum dose diarrhoea, cough, urticaria, erythroderma, and third trimesters, drugs that act directly on the
Hyzaar inhibitors because of cough, hypertensive patient with excretion, intermittent and slight increases in serum glycosides, diuretics, droperidol, hydrocortisone,
Hydrochlorothiazide 12.5 mg Tablet losartan 100 mg/ hydrochlorothiazide 25 mg once daily oedema, palpitations, headache, electrolyte renin-angiotensin system can cause foetal injury
left ventricular hypertrophy calcium may occur increase cholesterol and indomethacin, liquorice, lithium, methotrexate,
abnormalities, abdominal pain, nausea, and death. Discontinue as soon as possible if
triglyceride levels, precipitate with or without a methylprednisolone, prednisolone, propranolol,
bronchitis, pharyngitis, sinusitis, upper pregnancy is detected
history of allergy or bronchial asthma. Thiazides tolbutamide, triamcinolone
respiratory infection, skin rash, back pain
have also been reported to exacerbate or activate
systemic lupus erythematosus. Should not be
initiated in patients with intravascular volume
depletion (eg those treated with high dose diuretics),
black patients, lactation, children
rise to 3 times upper limit of normal and are Gastrointestinal upsets, headache, skin rashes, Use with caution with coumarin anticoagulants
persistent. This class of drug has been known to fatigue, pruritis, dry mouth, sleep disorders. Pregnancy, liver disease, hypersensitivity to and with immunosuppressive drugs, gemfibrozil
Lovastatin 20 mg Tablet Mevacor Hypercholesterolaemia and coronary heart disease 20 mg once daily. Maximum: 80 mg daily
cause myopathy and renal failure due to Rarely, hepatitis, hypersensitivity syndrome, lovastatin, lactation or niacin (as a lipid lowering agent) or
rhabdomyolysis. Concomitant administration of erythema multiforme, toxic epidermal necrolysis erythromycin. Itraconazole
fibrates, niacin, ciclosporin or erythromycin may
Inflammatory skin conditions such as boils and Avoid contact with eyes and other mucous Prolonged or repeated use may damage the
Magnesium Sulphate 45% Paste - Apply under dressing Hypersensitivity to magnesium sulfate Not known
carbuncles membranes surrounding skin
ADULT 5-10 ml by IM. CHILD 20-40 mg/kg body weight Hypotension, flushing, sweating, depression of
as a 20% solution by IM. Hypomagnesaemia: 0.5-1 reflexes, flaccid paralysis, hypothermia,
Treatment and prophylaxis of hypomagnesaemia. Impaired renal function and those receiving digitalis
mmol/kg body weight up to 160 mmol magnesium over circulatory collapse, depression of cardiac Additive central depressant effects with central
Prevention and treatment of life-threatening seizures in glycosides. Pregnancy and lactation. Product
Magnesium Sulphate 50% Injection - to 5 days. Eclampsia: IV 4 g over up to 20 minutes function, central nervous system depression, Heart block, myocardial damage nervous system depressants. Neuromuscular
the treatment of toxemias of pregnancy (pre-eclampsia contains aluminum therefore increasing the risk of
followed by IV infusion at rate of 1 g every hour. abnormal ECG, heart block, hypotension, blocking agents, cardiac glycosides, nifedipine
and eclampsia) aluminum toxicity
Recurrent seizures may require an additional IV bolus vasodilatation, blood coagulation disorder with
of 2-4 g (4 g if body weight over 70 kg) prolonged bleeding time
Renal impairment-nonabsorbable calcium,
magnesium or aluminum preparations such as Major: sodium polystyrene sulfonate (advoid).
Diarrhoea, systemic alkalosis has been reported
antacids or laxatives should not be used in patients Acute surgical abdomen, hypersensitivity to Moderate: tetracyclines, ketoconazole,
Magnesium Trisilicate Mixture - Heartburn, dyspepsia 10-20 ml 3-4 times daily before meals when administered orally with cation-exchange
receiving oral cation-exchange resins. Alternatively, antacids, hypophosphataemia itraconazole, dipyridamole, quinolones, captopril,
resins
the interaction may be avoided by administering the iron and aspirin (adjust frequency interval)
resin as an enema
ADULT 1-2 tablet to be chewed up to 6 times a day Tetracyclines, ketoconazole, itraconazole,
Magnesium Trisilicate Tablet - Heartburn, dyspepsia before meals. CHILD over 6 years one tablet to be Renal impairment Diarrhoea Hypersensitivity to antacids, hypophosphataemia dipyridamole, quinolones, captopril, iron and
taken 3-4 times a day aspirin
Aluminium hydroxide may react with phosphate to

As a buffering agent for reconstituting didanosine form insoluble aluminium phosphate. This can be
powder for oral administration so as to prevent acid DDI should be mixed with water and diluted with the overcome by regular intake of milk or phosphorus Gastrointestinal disturbances (constipation or
Magnesium, Aluminium Hydroxide
Maalox Plus degradation of didanosine which is used for the appropriate dose of antacids to a final concentration of supplements. Elevated serum magnesium ion diarrhoea), hypophosphatemia, seizures Severe debilitation, kidney failure Inhibits absorption of tetracyclines, vitamin
and Simethicone Suspension
treatment of paediatric patients (more than 6 months 10 mg per ml concentration may cause central nervous system (serious)
old) with symptomatic HIV infection depression. Impaired bowel motility, gastrointestinal
obstruction, upper gastrointestinal bleeding
Wet hair, apply shampoo and work up lather. Leave for May cause eye irritation and systemic absorption. Acute renal insufficiency has been described in
Neonates and infants. Known sensitivity to
Malathion 1 % Shampoo - Lice infestation 15 minutes and rinse, comb. Repeat if necessary after Keep preparation and medicated hair away from one patient associated with excessive exposure Not known
malathion or any of the vehicle ingredients
7 - 9 days heat or flame to a malathion spray
Cardiopulmonary dysfunction, renal dysfunction. An
in-line filter should be used during intravenous
0.25- 2 g/kg IV of a 15% to 25% solution over 30-60 administration. Maintain proper fluid and electrolyte Hyperkalaemia, diarrhoea, renal failure, acidosis, Anuria, pulmonary oedema/congestion, severe
Lithium toxicity (with diuretic induce
Mannitol 10% Injection (10 g/100 ml) - Cerebral oedema minutes. Safety and efficacy not established in children balance. Monitor urinary output. Renal dysfunction pulmonary oedema, seizure, thrombophlebitis, chronic heart failure, intracranial bleeding, renal
hyponatraemia)
under 12 years of age and solutions should be examined for crystals before urinary retention damage/dysfunction (after initiation of mannitol)
use. Solutions of 15% and 20% should always be
filtered
Cardiopulmonary dysfunction, renal dysfunction. An
in-line filter should be used during intravenous
0.25- 2 g/kg IV of a 15% to 25% solution over 30-60 administration. Maintain proper fluid and electrolyte Hyperkalaemia, diarrhoea, renal failure, acidosis, Anuria, pulmonary oedema/congestion, severe
Lithium toxicity (with diuretic induce
Mannitol 20% Injection (20 g/100 ml) - Cerebral oedema minutes. Safety and efficacy not established in children balance. Monitor urinary output. Renal dysfunction pulmonary oedema, seizure, thrombophlebitis, chronic heart failure, intracranial bleeding, renal
hyponatraemia)
under 12 years of age and solutions should be examined for crystals before urinary retention damage/dysfunction (after initiation of mannitol)
use. Solutions of 15% and 20% should always be
filtered
Congenital or acquired immune deficiency
Prophylaxis against measles and to prevent
Measle's Vaccine (Live Attenuated) By SC or IM injection, 0.5 ml as a single dose at 12 - 15 Hypersensitivity to egg protein and allergy to including HIV infection, children born to HIV
- development of infection (if given within 72 hours of Hyperthermia, mild mobiliform skin lesion Chemotherapeutic agents
Injection months of age neomycin positive mothers. Recent injection of
contact)
immunoglobulin
Children with untreated malignant disease or
Not suitable for prophylaxis following exposure to altered immunity and those receiving
Measles, Mumps and Rubella Vaccine For immunisation of children against measles, mumps mumps or rubella since the antibody response to the Malaise, fever, rash may occur following first immunosuppressive drugs or radiotherapy or
M-M-R Subcutaneous or by intramuscular injection, 0.5 ml Chemotherapeutic agents
Live and rubella mumps and rubella components is too slow for dose of measle, mumps and rubella vaccine high-dose corticosteroids, allergies to neomycin,
effective prophylaxis kanamycin, child who received another live
vaccine by injection within 3 weeks. Pregnancy
Hypersensitivity to mebeverine HCl, severe hepatic Dizziness, headache, nausea, peritonitis, skin Cystic fibrosis, porphyria, paralytic ileus,
Mebeverine HCl 135 mg Tablet Duspatalin Irritable bowel syndrome 135 mg 3 times daily Not known
insufficency, porphyria reactions hypersensitivity to any component of formulation
Use with caution in prostatic hyperthrophy, urinary
Meclozine HCl 25 mg and Pyridoxine retention, glaucoma and pyloroduodenal obstruction, Drowsiness, dry mouth, blurred vision, May enhanced sedative effect of central
Navidoxine Nausea and vomiting of pregnancy 1 - 2 tablet 2 - 3 times daily in severe cases Hypersensitivity to meclozine
50 mg Tablet hepatic disease, severe heart failure, asthma. Avoid headache, gastrointestinal disturbance depressants including alcohol
operating vehicles and machinery
Anorexia, nausea, diarrhoea, pain and induration
1 tablet 3 times daily. The dosage should be adjusted Discontinue medication if there is no response after
Mecobalamin 500 mcg Tablet Methylcobal Peripheral neuropathies at IM injection site. Headache, sweating or hot Not known Not known
according to age of patient and severity of symptoms taking orally for several months
sensation
Gastrointestinal distress, oedema, menstrual
i) 5-10 mg daily for 5-10 days. To produce optimum Thromboembolic disorders, liver disease, known
disorders, dermatologic effects, nausea, fatique,
secretory transformation 10 mg daily for 10 days ii) 5- or suspected malignancy of breast or genital
Medroxyprogesterone Acetate 10 mg i) Secondary amenorrhoea ii) Abnormal uterine depression, acne, hirsutism, breast tenderness,
Provera/Farlutal 10 mg daily for 5-10 days on day 15-21 of menstrual Depressions, diabetes, epilepsy, migraine, asthma organs, undiagnosed abnormal vaginal bleeding, Aminoglutethimide, rifampicin
Tablet bleeding due to hormonal imbalance thromboembolic phenomena, galactorrhoea,
cycle. Optimum secretory transformation 10 mg daily known or suspected pregnancy, hypersensitivity
decreased glucose tolerance, anaphylaxis,
for 10 days from day 15 of the cycle to medroxyprogesterone products
corticoid like reaction (high doses)
Vaginal bleeding, cholestatic jaundice,
depression, fluid retention, weight gain, Hypersensitivity to medroxyprogesterone,
Examination of breast, pelvis and PAP smear before
hirsutism, acne, visual abnormalities, nausea, thrombophlebitis, undiagnosed vaginal bleeding,
Medroxyprogesterone Acetate 100 Breast carcinoma, endometrial carcinoma, renal starting treatment. Diabetes, history of depression, Aminoglutethimide, alprazolam, bexarotane,
Provera/Farlutal 200-500 mg orally daily fatigue, galactorrhea, amenorrhea and impaired liver function, pregnancy, known or
mg Tablet carcinoma cardiac dysfunction, ocular disorder, prolonged nevirapine, rifampicin
anovulation, decreased glucose tolerance, suspected malignancy of breast or genital
progestin therapy and bone mineral density loss
thromboembolic phenomena, anaphylaxis, organs, missed abortion
corticoid-like activity (high doses)
Concurrent use with aminoglutethimide may
Thromboembolic disorders, liver disease, breast
result in decreased medroxyprogesterone
Depression, epilepsy, migraine, asthma, diabetes, or genital cancer, undiagnosed abnormal vaginal
Medroxyprogesterone Acetate 150 Prevention of pregnancy and to provide long term Gastrointestinal distress, oedema, menstrual efficacy. Concurrent use with nevirapine may
Provera/Farlutal To be administered every 3 month cardiac or renal dysfunction, fluid retention, bleeding, known or suspected pregnancy,
mg/3 ml Injection contraception disorders, dermatologic effects result in loss of contraceptive efficacy.
thromboembolic disorders, cerebral apoplexy hypersensitivity to medroxyprogesterone
Concurrent use with succinylcholine may result
products
in prolongation of neuromuscular blockade
Gastrointestinal distress, oedema, menstrual

i) 5-10 mg daily for 5-10 days. To produce optimum Thromboembolic disorders, liver disease, known
disorders, dermatologic effects, nausea, fatique,
secretory transformation 10 mg daily for 10 days ii) 5- or suspected malignancy of breast or genital
Medroxyprogesterone Acetate 5 mg i) Secondary amenorrhoea ii) Abnormal uterine depression, acne, hirsutism, breast tenderness,
Provera/Farlutal 10 mg daily for 5-10 days on day 15-21 of menstrual Depressions, diabetes, epilepsy, migraine, asthma organs, undiagnosed abnormal vaginal bleeding, Aminoglutethimide, rifampicin
Tablet bleeding due to hormonal imbalance thromboembolic phenomena, galactorrhoea,
cycle. Optimum secretory transformation 10 mg daily known or suspected pregnancy, hypersensitivity
decreased glucose tolerance, anaphylaxis,
for 10 days from day 15 of the cycle to medroxyprogesterone products
corticoid like reaction (high doses)
Vaginal bleeding, cholestatic jaundice,
depression, fluid retention, weight gain, Hypersensitivity to medroxyprogesterone,
Examination of breast, pelvis and PAP smear before
hirsutism, acne, visual abnormalities, nausea, thrombophlebitis, undiagnosed vaginal bleeding,
Medroxyprogesterone Acetate 500 Breast carcinoma, endometrial carcinoma, renal starting treatment. Diabetes, history of depression, Aminoglutethimide, alprazolam, bexarotane,
Provera/Farlutal 200-500 mg orally daily fatigue, galactorrhea, amenorrhea and impaired liver function, pregnancy, known or
mg Tablet carcinoma cardiac dysfunction, ocular disorder, prolonged nevirapine, rifampicin
anovulation, decreased glucose tolerance, suspected malignancy of breast or genital
progestin therapy and bone mineral density loss
thromboembolic phenomena, anaphylaxis, organs, missed abortion
corticoid-like activity (high doses)
Elderly, renal impairment, asthmatic sensitive to Diarrhoea, skin rash, allergic, glomerulonephritis,
ADULT: 250 - 500 mg 3 times daily after meals. CHILD Alendronate, ACEIs, antacids, beta-adrenergic
NSAIDs or salicylates, pregnancy, increased risk of non-oliguric renal failure, thrombocytopenia, Gastrointestinal ulceration or inflammatory bowel
Mefenamic Acid 250 mg Capsule Ponstan Mild to moderate pain over 6 months: 6.5 - 25 mg/kg daily 3 - 4 times daily for blockers, calcium channel blocker, ciclosporin,
serious cardivascular thrombotic events, myocardial reversible haemolytic anaemia, hypertension, disease, renal/hepatic impairment
not longer than 7 days except in juvenile arthritis diuretics, methotrexate, sulphonylureas, warfarin
infarction oedema, myocardial infarction
Elderly, renal impairment, asthmatic sensitive to Diarrhoea, skin rash, allergic, glomerulonephritis,
ADULT: 250 - 500 mg 3 times daily after meals. CHILD Alendronate, ACEIs, antacids, beta-adrenergic
NSAIDs or salicylates, pregnancy, increased risk of non-oliguric renal failure, thrombocytopenia, Gastrointestinal ulceration or inflammatory bowel
Mefenamic Acid 250 mg Tablet Ponstan Mild to moderate pain over 6 months: 6.5 - 25 mg/kg daily 3 - 4 times daily for blockers, calcium channel blocker, ciclosporin,
serious cardivascular thrombotic events, myocardial reversible haemolytic anaemia, hypertension, disease, renal/hepatic impairment
not longer than 7 days except in juvenile arthritis diuretics, methotrexate, sulphonylureas, warfarin
infarction oedema, myocardial infarction
Quinine or related compounds, cardioactive
agents eg beta-blockers, oral live typhoid
Treatment of malaria : ADULT and CHILD 25 mg/kg Nausea, vomiting, dizziness, vertigo, loss of vaccines, amiodarone, astemizole, chloral
usually given over 2-3 days. Prophylaxis of malaria : balance, headache, somnolence, sleep hydrate, chloroquine, chlorpromazine,
Impaired liver function, cardiac conduction diseases,
ADULT 250 mg once a week. CHILD over 5 kg : 5 disorders, diarrhoea, abdominal pain, anorexia, Hypersensitivity, history of psychosis or clarithromycin, enflurane, erythromycin,
Mefloquine HCl 250 mg Tablet Lariam For multi-drug resistant cases of malaria only pregnancy, lactation, young children, epilepsy and
mg/kg once a week; prophylaxis should start 1-3 weeks neurological and psychiatric disturbances. convulsions fluconazole, fluoxetine, haloperidol, halothane,
psychiatric disorders
before departure and continue for 4 weeks after last Rarely, Stevens-Johnson syndrome, isoflurane, octreotide, prochlorperazine,
exposure atrioventricular block and encephalopathy propranolol, quetiapine, quinidine, quinine,
risperidone, sulfamethoxazole, trimethoprim,
vasopressin
History of gastrointestinal disease, liver cirrhosis,
i) initially 7.5 mg daily. May be increased to 15 mg daily dehydration. Chronic heart failure, nephrotic Dyspepsia, nausea, abdominal pain, pruritis, skin Active peptic ulceration, pregnancy, lactation, NSAIDs, salicylates, oral anticoagulants,
Only for patients not responding to other NSAIDs in the
ii) initially 15 mg daily. May be reduced to 7.5 mg daily. syndrome, overt renal disease, recent major surgical rash, constipation. Vomiting, flatulence, hypersensitivity to NSAIDs or aspirin, severe ticlopidine, heparin, thrombolytics, lithium,
Meloxicam 7.5 mg Tablet Mobic treatment of i) painful osteoarthritis ii) rheumatoid
Maximum 15 mg daily. Child under 12 years not procedures. Withdraw if peptic ulceration or diarrhoea, anaemia, pruritus, lightheadedness, hepatic insufficiency, non-dialysed severe renal methotrexate, IUD, diuretics, antihypertensives,
arthritis
recommended gastrointestinal bleeding occurs. Concomitant headache, oedema insufficiency. Children less than 15 year cholestyramine, ciclosporin
anticoagulant or diuretic treatment. Elderly
Bone marrow depression, mild gastrointestinal
i) Multiple myeloma ii) Neuroblastoma, i) 8 - 10 mg/m2 for 4 days every 4 weeks ii) 10 - 35 Use with caution in renal impairment and elderly. effects, diarrhoea, pulmonary fibrosis, interstitial
Lactation, pregnancy, hypersensitivity to
Melphalan 2 mg Tablet Alkeran rhabdomyosarcoma iii) Recurrent neuroblastoma mg/m2 once every month For dose regimes, refer to Dose adjustment with blood count. To be taken on pneumonitis, alopecia, syndrome of Ciclosporine, steroid, cimetidine
melphalan, severe myelosuppression
(palliative) protocols empty stomach 1 hour before or 2 hours after meals inappropriate ADH secretion, secondary
malignancy
Bone marrow depression, mild gastrointestinal Phenytoin, clozapine, ciclosporin, digoxin,
effects, diarrhoea, pulmonary fibrosis, interstitial nalidixic acid, trastuzumab, natalizumab,
High dose conditioning therapy for stem cell 200 mg/ m2 IV infusions in divided doses for Day 1 to Use with caution in renal impairment and elderly. Lactation, pregnancy, hypersensitivity to
Melphalan 50 mg Injection pneumonitis, alopecia, syndrome of leflunomide, Vitamin K Antagonists, Vaccines
transplantation in multiple myeloma day 3 followed by IV infusions of autologous stem cells Dose adjustment with blood count melphalan, severe myelosuppression
inappropriate ADH secretion, secondary Inactivated or live, cisplatin, carmustine, alpha
malignancy interferons
Immunisation against meningococcal diseases caused
Meningococcal A, C, Y, W 135 Infants less than 18 months have a lower rate of Temporary hyperthermia and mild erythema at Hypersensitivity to thiomersal or any component Decreased effect with administration of
by Neisseria meningitis Group A, Group C, Group Y or Prophylaxis: 0.5 ml subcutaneously
Vaccine Injection seroconversion to C, Y and W135 injection site of the form immunoglobulin within 1 month
Group W-135
Discontinue if the ovaries become enlarged or
abdominal pain occurs. Special care should be Undiagnosed abnormal vaginal bleeding,
Menotrophin 150 IU Injection (Follicle Treatment of infertility where clomifene has fail or exercised to monitor for pregnancy. During ovulation Adnexal torsion (with ovarian enlargement), intracranial bleeding, adrenal or thyroid
Stimulating Hormone 150 IU and stimulation of follicle growth as part of an assisted SC or IM injection according to patients response induction therapy and for a two week period after ovarian cysts, flu like symptoms, pulmonary or disorders, preexisting ovarian cysts or Not known
Luteinizing Hormone 150 IU) reproductive technology (ART) therapy, patients should be examined every other vascular complications enlargement, primary ovarian or testicular failure,
day for signs of excessive ovarian stimulation. pituitary tumor, pregnancy
Multiple births can occur
Menotrophin 75 IU Injection (Follicle Treatment of infertility where clomifene has fail or exercised to monitor for pregnancy. During ovulation Adnexal torsion (with ovarian enlargement), intracranial bleeding, adrenal/thyroid disorders,
Stimulating Hormone 75 IU and stimulation of follicle growth as part of an assisted SC or IM Injection according to patient's response induction therapy and for a two-week period after ovarian cysts, flu-like symptoms, pulmonary/ preexisting ovarian cysts/enlargement, primary Not known
Luteinizing Hormone 75 IU) reproductive technology (ART) therapy, patients should be examined every other vascular complications ovarian/testicular failure, pituitary tumor,
day for signs of excessive ovarian stimulation. pregnancy
Menotrophin, Highly Purified 75 IU Treatment of infertility where clomifene has fail or exercised to monitor for pregnancy. During ovulation Adnexal torsion (with ovarian enlargement), intracranial bleeding, adrenal/thyroid disorders,
Injection (Follicle Stimulating Hormone Menopur stimulation of follicle growth as part of an assisted SC or IM injection according to patients response induction therapy and for a two-week period after ovarian cysts, flu-like symptoms, pulmonary/ preexisting ovarian cysts/enlargement, primary Not known
75 IU and Luteinizing Hormone 75 IU) reproductive technology (ART) therapy, patients should be examined every other vascular complications ovarian/testicular failure, pituitary tumor,
day for signs of excessive ovarian stimulation. pregnancy
Menthol 1.6% in Industrial Methylated Hypersentivity reactions including contact
- Decongestion of the upper respiratory tract As directed for local use Not known Not known Not known
Spirit Inhalation dermatitis
Dose reduction with an abnormal liver or renal
function. Myelosuppression (temporarily discontinue
ADULT: Maintenance therapy: 60 - 75 mg/m2 body
treatment with an abnormally large fall in any formed
i) Langerhan's cell histocytosis ii) Acute lymphoblastic surface area once daily. Adjust doses depending on Bone marrow depression, nausea and vomiting, Lactation, pregnancy, severe bone marrow
blood element), inherited deficiency of the enzyme Allopurinol, methotrexate, warfarin, decreased
Mercaptopurine 50 mg Tablet Puri-Nethol leukaemia iii) Acute promyelocytic leukaemia APML peripheral blood counts. CHILD: 2.5 mg/kg body weight hepatotoxicity, rash, hyperpigmentation, suppression, severe liver disease,
thioguanine methyltransferase (TPMT), anticoagulant effectiveness, sulfasalazine
(maintenance) or 25 - 100 mg/m2 body surface area once daily hyperuricaemia hypersensitivity to mercaptopurine
hepatotoxicity, reduce dosage when administered
according to protocol. Refer to protocols
with allopurinol, pregnancy. Take on an empty
stomach
History of hypersensitivity to carbapenems or other
beta-lactam antibiotics, penicillins and
Local injection site reactions, rash, pruritus,
i. Emperical treatment for presume infections in patients cephalosporins. Monitor transaminase and bilirubin
urticaria, abdominal pain, nausea, vomiting,
(adult and children) with febrile neutropenia, used as levels when used in hepatic disease. Not
ADULT: 0.5 - 1g 3 times daily, CHILD: 10 - 20 mg/kg 3 diarrhoea, headache, paraesthesia, oral and Hypersensitivity to meronem, carbapenems,
Meropenem 1 g Injection Meronem monotherapy or in combination with anti-virals or recommended for MRSA infections. Consider Probenecid, valproic acid, typhoid vaccine
times daily (except meningitis 40 mg/kg) vaginal candidiasis, reversible penicillins or other beta-lactam antibiotics
antifungal agent ii. Septicaemia iii. Serious infections in diagnosis of pseudomembranous colitis in patients
thrombocytopenia, leucopenia, eosinophilia,
renal impaired patients who develop diarrhoea. Critically ill patients with
thrombocytopenia, neutropenia
Pseudomonas aeruginosa infection. Pregnancy and
lactation
History of hypersensitivity to carbapenems or other
beta-lactam antibiotics, penicillins and
Local injection site reactions, rash, pruritus,
i. Emperical treatment for presume infections in patients cephalosporins. Monitor transaminase and bilirubin
urticaria, abdominal pain, nausea, vomiting,
(adult and children) with febrile neutropenia, used as levels when used in hepatic disease. Not
ADULT: 0.5 - 1g 3 times daily, CHILD: 10 - 20 mg/kg 3 diarrhoea, headache, paraesthesia, oral and Hypersensitivity to meronem, carbapenems,
Meropenem 500 mg Injection Meronem monotherapy or in combination with anti-virals or recommended for MRSA infections. Consider Probenecid, valproic acid, typhoid vaccine
times daily (except meningitis 40 mg/kg) vaginal candidiasis, reversible penicillins or other beta-lactam antibiotics
antifungal agent ii. Septicaemia iii. Serious infections in diagnosis of pseudomembranous colitis in patients
thrombocytopenia, leucopenia, eosinophilia,
renal impaired patients who develop diarrhoea. Critically ill patients with
thrombocytopenia, neutropenia
Pseudomonas Aeruginosa infection. Pregnancy and
lactation
Ulcerative colitis : 1 g suppository insert rectally once
daily at bedtime. The dose may be increased to 500 mg
3 times daily if the response is inadequate after 2
Inflammatory bowel disease of ulcerative colitis and Allergic exanthema, drug fever, bronchospasm, Severe hepatic and renal function disorders,
weeks of therapy. To achieve maximum benefit, it is Sulfonylureas, coumarins, methotrexate,
Mesalazine 1 g Suppository Salofalk Crohn's disease. Only for patients who cannot tolerate Pregnancy, lactation, elderly lupus erythematosus-like syndrome, hepatitis, active peptic ulcer, blood clotting abnormalities,
recommended that the suppository be retained in the probenecid, sulfinpyrazone, frusemide, rifampicin
or do not respond to Sulfasalazine pancreatitis, hair loss salicylate hypersensitivity, babies and infants
rectum for a minimum of 1 to 3 hours or longer. The
usual course of therapy, depending upon response,
may last from 3 to 6 weeks. CHILD not recommended
Ulcerative colitis : 1 g suppository insert rectally once

daily at bedtime. The dose may be increased to 500 mg
3 times daily if the response is inadequate after 2
weeks of therapy. To achieve maximum benefit, it is Sulfonylureas, coumarins, methotrexate,
Mesalazine 250 mg Suppository Salofalk Crohn's disease. Only for patients who cannot tolerate Pregnancy, lactation, elderly lupus erythematosus-like syndrome, hepatitis, active peptic ulcer, blood clotting abnormalities,
recommended that the suppository be retained in the probenecid, sulfinpyrazone, frusemide, rifampicin
rectum for a minimum of 1 to 3 hours or longer. The
usual course of therapy, depending upon response,
may last from 3 to 6 weeks. CHILD not recommended
Inflammatory bowel disease of ulcerative colitis and ADULT: 250 - 500 mg 3 - 4 times daily for 3 - 6 weeks. Allergic exanthema, drug fever, bronchospasm, Severe hepatic and renal function disorders,
Sulfonylureas, coumarins, methotrexate,
Mesalazine 250 mg Tablet Salofalk Crohn's disease. Only for patients who cannot tolerate CHILD up 2 years with Crohn's disease: 20 - 30 Pregnancy, lactation, elderly lupus erythematosus-like syndrome, hepatitis, active peptic ulcer, blood clotting abnormalities,
probenecid, sulfinpyrazone, frusemide, rifampicin
or do not respond to Sulfasalazine mg/daily in divided doses pancreatitis, hair loss salicylate hypersensitivity, babies and infants
Inflammatory bowel disease of ulcerative colitis and ADULT: 250 - 500 mg 3 - 4 times daily for 3 - 6 weeks. Allergic exanthema, drug fever, bronchospasm, Severe hepatic and renal function disorders,
Sulfonylureas, coumarins, methotrexate,
Mesalazine 500 mg Tablet Salofalk Crohn's disease. Only for patients who cannot tolerate CHILD up 2 years with Crohn's disease: 20 - 30 Pregnancy, lactation, elderly lupus erythematosus-like syndrome, hepatitis, active peptic ulcer, blood clotting abnormalities,
probenecid, sulfinpyrazone, frusemide, rifampicin
or do not respond to Sulfasalazine mg/daily in divided doses pancreatitis, hair loss salicylate hypersensitivity, babies and infants
60 ml (4g) at bedtime, retained overnight, Sulfonylureas, coumarins, methotrexate,
Mesalazine 6.67% w/w Enema Salofalk Crohn's disease. Only for patients who cannot tolerate Pregnancy, lactation, elderly lupus erythematosus-like syndrome, hepatitis, active peptic ulcer, blood clotting abnormalities,
approximately 8 hours probenecid, sulfinpyrazone, frusemide, rifampicin
IV injection at a dosage of 20% of the corresponding Warfarin: increased risk of bleeding. In vitro
oxazaphosphorine dose at the times 0 hour Do not use multi-dose vial in infants and neonates Hypotension, nausea, vomiting, headache, limb mesna is incompatible with cisplatin. The
For prevention of urotoxic effects of
(concurrently with the oxazaphosphorine), 4 hours and due to benzyl alcohol content, patients treated with pain, headache, gastrointestinal effects, skin combination of an oxazaphosphorine cytostatic
Mesna 400 mg/4 ml Injection Uromitexan oxazaphosphorines e.g. ifosfamide and Hypersensitivity to mesna/other thiol compounds
8 hours thereafter. CHILD: Dose given at greater mesna may have false positive test for urinary rash, diarrhoea, abdominal pain, transient drop in agent with mesna and cisplatin in the same
cyclophosphamide
frequency (e.g. 6 times) and a shorter intervals (e.g. 3 ketones, pregnancy blood pressure, increase in pulse rate infusion solution is not stable and is not to be
hours) used
Cationic drugs that are eliminated by renal
tubular secretion. Thiazide and other diuretics,
Adrenal or pituitary insufficiency elderly, debilitated corticosteroids, phenothiazines, thyroid products,
or malnourished patients, excessive alcohol intake, estrogens, oral contraceptives, phenytoin,
hypoxic states due to shock, acute chronic heart Renal disease or renal dysfunction, chronic heart nicotinic acid, sympathomimetics, calcium
As second-line therapy when diet, exercise and initial
failure or acute myocardial infarction, lactic acidosis, Hypoglycemia, lactic acidosis, cobalamin failure requiring pharmacologic treatment, acute channel blockers and isoniazid may produce
Metformin 500 mg and Glibenclamide treatment with sulphonylurea or metformin do not result One tablet twice daily, titrate up to a maximum daily
Glucovance severe metabolic complication due to accumulation deficiency, abdominal pain, diarrhoea, nausea or chronic metabolic acidosis, including diabetic hyperglycaemia and lead to loss of glycaemic
2.5 mg Tablet in adequate glycemic control in patients with type 2 dose of 2000 mg metformin/20 mg glibenclamide
of metformin, liver or renal disease, peripheral and vomiting, dizziness ketoacidosis with or without coma, control. The hypoglycaemic action of
diabetes mellitus
vascular disease, pulmonary disease, pregnancy or hypersensitivity to metformin or glibenclamide sulphonylureas may be potentiated by NSAIDs
lactation, stress caused by infection, fever, trauma or and other highly protein-bound drugs,
surgery salicylates, sulfonamides, chloramphenicol,
probenecid, coumarins, MAOIs, β-blockers,
ciprofloxacin, oral miconazole
Cationic drugs that are eliminated by renal
tubular secretion. Thiazide and other diuretics,
Adrenal or pituitary insufficiency elderly, debilitated corticosteroids, phenothiazines, thyroid products,
or malnourished patients, excessive alcohol intake, estrogens, oral contraceptives, phenytoin,
hypoxic states due to shock, acute chronic heart Renal disease or renal dysfunction, chronic heart nicotinic acid, sympathomimetics, calcium
As second-line therapy when diet, exercise and initial
failure or acute myocardial infarction, lactic acidosis, Hypoglycemia, lactic acidosis, cobalamin failure requiring pharmacologic treatment, acute channel blockers and isoniazid may produce
Metformin 500 mg and Glibenclamide treatment with sulphonylurea or metformin do not result One tablet twice daily, titrate up to a maximum daily
Glucovance severe metabolic complication due to accumulation deficiency, abdominal pain, diarrhoea, nausea or chronic metabolic acidosis, including diabetic hyperglycaemia and lead to loss of glycaemic
5 mg Tablet in adequate glycemic control in patients with type 2 dose of 2000 mg metformin/20 mg glibenclamide
of metformin, liver or renal disease, peripheral and vomiting, dizziness ketoacidosis with or without coma, control. The hypoglycaemic action of
diabetes mellitus
vascular disease, pulmonary disease, pregnancy or hypersensitivity to metformin or glibenclamide sulphonylureas may be potentiated by NSAIDs
lactation, stress caused by infection, fever, trauma or and other highly protein-bound drugs,
surgery salicylates, sulfonamides, chloramphenicol,
probenecid, coumarins, MAOIs, β-blockers,
ciprofloxacin, oral miconazole
Diabetic pre-coma, ketoacidosis, renal
Dehydration, serious infection or trauma, patients Metallic taste, epigastric discomfort, nausea,
Metformin HCl 500 mg Extended Diabetes mellitus who experienced gastrointestinal side 500 mg once daily. Maximum dose 2000 mg once daily impairment, chronic liver disease, cardiac failure,
Glucophage XR undergoing surgery, pregnancy, lactation, children. vomiting, decreased vitamin B12 absorption. Alcohol, sulfonylureas, cimetidine, anticoagulants
Release Tablet effects with normal metformin with evening meal hypoxaemia, history of lactic acidosis, acute
Monitor serum B12 levels annually Rarely, diarrhoea, anorexia
alcohol intoxication, hypoxia
Anorexia, nausea, vomiting, diarrhoea (usually Diabetic pre-coma, ketoacidosis, renal
Dehydration, serious infection or trauma, patients
500 mg 3 times daily or 850 mg twice daily with food, transient), abdominal pain, metalic taste, rarely impairment, chronic liver disease, cardiac failure,
Metformin HCl 500 mg Tablet Glucophage Diabetes mellitus undergoing surgery, pregnancy, lactation, children. Alcohol, sulfonylureas, cimetidine, anticoagulants
maximum: 3 g daily in 3 divided doses lactic acidosis (withdraw treatment), decreased hypoxaemia, history of lactic acidosis, acute
Monitor serum B12 levels annually
vitamin-B12 absoption, erythema alcohol intoxication, hypoxia
May cause dependence on prolonged use. Avoid
alcoholic beverages, effects on ability to drive or Constipation, nausea, vomiting, asthenia, Hypersensitivity to methadone, severe hepatic
10 - 40 mg orally once daily. Increased by up to 10 mg Buprenorphine, didanosine, efavirenz,
operate machine. Methadone, even in low doses is a dizziness, somnolence, cardiac arrest, disease impairment, respiratory depression, obstructive
daily (maximum increase 30 mg weekly) until no signs fluconazole, fluvoxamine, naltrexone, nevirapine,
Methadone 5mg/ml Syrup Detoxification treatment of narcotic addiction special hazard for children, non-dependent adults of cardiovascular system, shock, respiratory airways disease, ulcerative colitis, concomitant
of withdrawal or intoxication, usual dose range 60 - 120 rifampin, risperidone, ritonavir, voriconazole,
are also at risk of toxicity and dependent adults are arrest, respiratory depression, diaphoresis, administration with monoamine oxidase inhibitors
mg daily. CHILD not recommended zidovudine
at risk if tolerance is incorrectly asessed during constipation, sedation (MAOIs) or within 2 weeks of discontinuation
induction
Impaired renal function, pleural effusion, ascitis, poor
nutritional status, myelosuppression, acute or
chronic hepatotoxicity (elevated transaminases,
fibrosis, cirrhosis), pulmonary toxicity (dry cough,
pneumonitis), nephrotoxicity with high-dose therapy,
i) ADULT: 20 mg/m2 weekly. CHILD: 20 - 30 mg/m2
patients with a creatinine clearance of less than 60
weekly according to protocol ii) Relapsed acute Myelosuppression, nausea, vomiting, diarrhoea,
ml/minute should not receive high-dose
lymphoblastic leukaemia (ALL): 100 mg/m2/day for 5 mucositis, transient abnormalities in serum levels
methotrexate, high-dose or intrathecal methotrexate Alcohol, aminophenazone, amiodarone,
days 6 weekly according to protocol iii) Dose used by of liver enzymes, acute hepatocellular injury (not
i) Acute lymphoblastic leukaemia and acute therapy must not be formulated with diluents Pregnancy, lactation, severe myelosuppression, amitriptyline, antibiotics, cisplatinum, ciclosporin,
dermatologist: 5 - 25 mg weekly. Liver biopsy after common at standard dose), erythematous rash,
promyelocytic leukemia (maintenance) ii) Extensive containing preservatives, women of child-bearing serious renal and liver impairment, increase risk cytosine arabinoside, diclofenac, etoposide,
Methotrexate 2.5 mg Tablet - cumulative dose of 1.5 gram and repeat liver biopsy pruritis, pigmentary changes, photosensitivity,
plaque psoriasis, erythrodermic psoriasis, pustular potential, gastrointestinal toxicity (vomiting, of toxicity in the presence of third space fluid etretinate, 5-fluorouracil, NSAIDs, salicylates,
with additional gram received. Maximum cumulative acute renal failure (high dose), headache,
psoriasis, Reiter's syndrome, connective tissue disease diarrhoea, stomatitis), tumour lysis syndrome in (pleural effusion, ascites) nephrotoxic drugs, sulfonamides, tetracyclines,
dose is 4 gram. Monitor full blood count (FBC), renal drowsiness, dizziness, acute confusion (high
patients with rapidly growing tumors, severe and teniposide, warfarin, folic acid
and liver function iv) Rheumatoid arthritis, psoriatic dose), interstitial pneumonitis,
sometimes fatal skin reactions, potentially fatal
arthropathy: dose used by rheumatologist: 2.5 mg/week myelosuppression, interstitial pneumonitis
infections (especially Pneumocystis carinii
orally starting dose, increasing to 7.5 - 20 mg/weekly
pneumonia), neurotoxicity (leukoencephalopathy,
seizures), high-dose methotrexate therapy will
generally require the use of leucovorin rescue, care
should be taken in handling the body fluids of
persons receiving antineoplastic agents
i) 50 mg/m2 once every 2 - 3 weeks in combination with

other drugs ii) 50 mg IV Day 1, 3, 5, 9 every 3 weeks.
For high risk gestational trophoblastic disease, use 100
Patients with a creatinine clearance of less than 60
mg/m2 as part of EMA-CO regime iii) High dose
ml/minute, impaired renal function, pleural effusion,
regimes: 500 - 3000 mg/m2 per dose may be used,
ascitis and poor nutritional status should not receive
employing the 500 mg preparations. CHILD: Central
high-dose methotrexate. High-dose or intrathecal
nervous system prophylaxis for acute leukaemia 2
methotrexate therapy must NOT be formulated with
gm/m2 over 24 hours with folinic acid rescue, 3 doses
diluents containing preservatives. High-dose Myelosuppression, nausea, vomiting, diarrhoea,
for B-cell lineage. 4 doses for T-lineage all every 3
methotrexate therapy requires the use of leucovorin mucositis, transient abnormalities in serum levels
weeks. Relapse acute lymphoblastic leukaemia (ALL): Alcohol, aminophenazone, amiodarone,
rescue. Myelosuppression, acute or chronic of liver enzymes, acute hepatocellular injury (not
1 gm/m2 over 36 hours with folinic acid rescue every 3 Pregnancy, lactation, severe myelosuppression, amitriptyline, antibiotics, cisplatinum, ciclosporin,
i) Solid tumours ii) Gestational trophoblastic disease iii) hepatotoxicity (elevated transaminases, fibrosis, common at standard dose), erythematous rash,
weeks for 9 doses, maintenance: 50 mg/m2 every 2 serious renal and liver impairment, increase risk cytosine arabinoside, diclofenac, etoposide,
Methotrexate 50 mg Injection - Acute leukaemia/lymphomas iv) Rheumatoid arthritis, cirrhosis), pulmonary toxicity (dry cough, pruritis, pigmentary changes, photosensitivity,
weeks. B-cell lymphoma: 3 gm/m2 over 3 hours with of toxicity in the presence of third space fluid etretinate, 5-fluorouracil, NSAIDs, salicylates,
psoriatic arthropathy, severe/erythrodermic psoriasis pneumonitis). Women of child-bearing potential, acute renal failure (high dose), headache,
folinic acid rescue for three doses. Methotrexate level (pleural effusion, ascites) nephrotoxic drugs, sulfonamides, tetracyclines,
gastrointestinal toxicity (vomiting, diarrhoea, drowsiness, dizziness, acute confusion (high
monitoring recommended when using high dose teniposide, warfarin, folic acid
stomatitis), tumour lysis syndrome in patients with dose), interstitial pneumonitis,
regimens. The 500 mg strength is not for intrathecal (IT)
rapidly growing tumors, severe and sometimes fatal myelosuppression, interstitial pneumonitis
use. Dosage for intrathecal treatment and prophylaxis
skin reactions, potentially fatal infections (especially
in leukaemia: less than 1 year: 5 mg, 1 - 2 years: 7.5
pneumocystis carinii pneumonia), neurotoxicity
mg, 2 - 3 years: 10 mg, more than 3 years: 12.5 mg. IT
(leukoencephalophathy, seizures), care should be
preparation must be clearly stated/verified. ENSURE
taken in handling the body fluids of persons
THAT PREPARATION IS SUITABLE FOR
receiving antineoplastic agents
INTRATHECAL USE iv) Dose used by rheumatologist:
10 - 15 mg IM injection or oral weekly. Dose used by
dermatologist: 10 - 25 mg IM injection weekly
Patients with a creatinine clearance of less than 60
i) 50 mg/m2 once every 3 weeks in combination with
ml/minute, impaired renal function, pleural effusion,
other drugs (for this dose, use the 50 mg preparation)
ascitis or poor nutritional status should not receive
ii) 50 mg IV Day 1, 3, 5, 9 every 3 weeks. For high risk
high-dose methotrexate. High-dose or intrathecal
gestational trophoblastic disease, use 100 mg/m2 as
methotrexate therapy must NOT be formulated with
part of EMA-CO regime iii) High dose regimes: 500 -
diluents containing preservatives. High-dose Myelosuppression, nausea, vomiting, diarrhoea,
3000 mg/m2 per dose may be used, employing the 500
methotrexate therapy requires the use of leucovorin mucositis, transient abnormalities in serum levels
mg preparations. CHILD: Central nervous system Alcohol, aminophenazone, amiodarone,
rescue. Myelosuppression, acute or chronic of liver enzymes, acute hepatocellular injury (not
prophylaxis for acute leukaemia 2 gm/m2 over 24 hours Pregnancy, lactation, severe myelosuppression, amitriptyline, antibiotics, cisplatinum, ciclosporin,
hepatotoxicity (elevated transaminases, fibrosis, common at standard dose), erythematous rash,
i) Solid tumours ii) Gestational trophoblastic disease iii) with folinic acid rescue, 3 doses for B-cell lineage. 4 serious renal and liver impairment, increase risk cytosine arabinoside, diclofenac, etoposide,
Methotrexate 500 mg/20 ml Injection - cirrhosis), pulmonary toxicity (dry cough, pruritis, pigmentary changes, photosensitivity,
Acute leukaemias, lymphomas doses for T-lineage all every 3 weeks. Relapse acute of toxicity in the presence of third space fluid etretinate, 5-fluorouracil, NSAIDs, salicylates,
pneumonitis). Women of child-bearing potential, acute renal failure (high dose), headache,
lymphoblastic leukaemia (ALL): 1 gm/m2 over 36 hours (pleural effusion, ascites) nephrotoxic drugs, sulfonamides, tetracyclines,
gastrointestinal toxicity (vomiting, diarrhoea, drowsiness, dizziness, acute confusion (high
with folinic acid rescue every 3 weeks for 9 doses, teniposide, warfarin, folic acid
stomatitis), tumour lysis syndrome in patients with dose), interstitial pneumonitis,
maintenance: 50 mg/m2 every 2 weeks. B-cell
rapidly growing tumors, severe and sometimes fatal myelosuppression, interstitial pneumonitis
lymphoma: 3 gm/m2 over 3 hours with folinic acid
skin reactions, potentially fatal infections (especially
rescue for three doses. Methotrexate level monitoring
Pneumocystis carinii pneumonia), neurotoxicity
recommended when using high dose regimens. THE
(leukoencephalophathy, seizures), care should be
500 MG STRENGTH IS NOT FOR INTRATHECAL
taken in handling the body fluids of persons
USE
receiving antineoplastic agents
Hepatic insufficiency and diseases associated
with photosensitivity. Idiosyncratic reactions to
Apply 0.1% lotion to area to be exposed to the UVA Erythema, pain of skin, pruritus, nausea,
Methoxsalen 1% Repigmenting agent in vitiligo in conjuction with After each UVA treatment, thoroughly wash treated psoralens, specific history of light sensitive Phenytoin may decreased methoxsalen
Methoxsalen 1% Lotion light ( need to dilute the 1% lotion to 0.1% lotion, dizziness, headache, fatigue, neoplasm of skin,
Lotion controlled doses of UVA or sunlight areas and protect from UVA disease, melanoma or history of melanoma, effectiveness
otherwise the skin will burn) precancerous, hepatotoxicity
invasive squamous cell carcinomas, aphakia.
Children less than 12 years
Breast feeding, exposure to sunlight or UVA History of idiosyncratic reactions to psoralens,
radiation, ocular changes, patients with a history of history of light sensitive disease states (lupus
0.2 - 0.6 mg/kg/body weight. For repigmentation of Erythema, pruritus, headache, dizziness, fatigue,
Protection before exposure to sunlight, psoriasis and previous arsenic exposure should be observed for erythematosus, porphyria cutanea tarda, Phenytoin may decreased methoxsalen
Methoxsalen 10 mg Capsule Meladinine larger lesions (greater than 6 cm sq): 20 mg/day 2 nausea, skin pain, hepatotoxicity, precancerous
vitiligo signs of carcinoma, patients with a history of erythropoietic protoporphyria, variegate effectiveness
hours before exposure. Take with food or milk changes
previous radiation therapy or Grenz ray therapy porphyria, xeroderma pigmentosum, albinism).
should be observed History of melanoma
Relief of pain associated with musculoskeletal Extreme overdosage results in excessive
Methyl Salicylate 25% Ointment - To be applied to affected area Avoid contact with eyes, open wounds Patient with aspirin or salicylate idiosyncrasy Not known
discomfort irritation, tinnitus, nausea, vomiting
To be used only for i) Post-operative cases with dry
Methylcellulose 1% with 50 mg
- eye ii) Unconscious patients in critical care unit (CCU) 1 to 4 times daily depending on severity of cases Not known Not known Not known Not known
Vitamin C Eye Drops
with exposure keratitis
Avoid abrupt withdrawal, congestive heart failure,
250 mg 2 - 3 times daily, gradually increased at dialysis patients (risk of hypertension following Sedation, headache, weakness, dizziness,
Hypersensitivity to methyldopa, history of
intervals of 2 or more days, maximum; 3 g/day. procedure), oedema, haemolytic anaemia, parkinsonism, bradycardia, orthostatic Antihypertensive drugs, lithium, monoamine
Methyldopa 250 mg Tablet Aldomet Hypertension hepatitis, autonomic dysfunction, bilateral
ELDERLY initially 125 mg twice daily, increased hypotension, liver disease, severe bilateral hypotension, GI symptoms, hepatic impairment, oxidase inhibitors (MAOIs)
cardiovascular disease
gradually, maximum; 2 g daily cerebrovascular disease (risk of choreoathetotic impotence
movements)
Haemolytic anaemia (Heinz-body anaemia) and Hypertension, hypotension, sweating symptom,
hyperbilirubinaemia in neonates who had been abdominal pain, diarrhea, nausea, vomiting Hypersensitivity to methylene blue, severe renal
For treatment of idiopathic and drug-induced 1 to 2 mg/kg (0.1 to 0.2 mL/kg of a 1% solution) IV very
Methylene Blue 1% Injection - exposed to methylene blue in the amniotic cavity. Do ,dizziness, headache, confusion, cardiac impairment, methaemoglobinemia in cyanide Not known
methaemoglobinemia slowly over several minutes
NOT administer by subcutaneous or intrathecal dysrhythmia, malignant hyperthermia, hemolytic poisoning, intraspinal injection
injection. G6PD deficiency, renal impairment anemia, methemoglobinemia
May exacerbate behavioral disturbance and thought
Nervousness, insomnia, decreased appetite.
disorder in psychotic patients. Not for severe
Ocassionally headache, drowsiness, dizziness,
CHILD over 6 years, initially 5 mg 1 - 2 times daily, depression. Chronic abuse can lead to marked Anxiety and tension states, agitation, tics, tics in
dry mouth, tachycardia, palpitations, arrhythmias,
increased if necessary at weekly intervals by 5 - 10 mg tolerance and psychic dependence. Epilepsy and siblings, familial history or diagnosis of Tourette's
changes in blood pressure and heart rate. Pressor agents, MAOIs, anticoagulants,
Hyperkinetic disorder (attention deficit hyperactivity daily to maximum of 60 mg daily in divided doses; hypertension. Monitor blood count during long-term syndrome, glaucoma, hyperthyrodism, cardiac
Methylphenidate HCl 10 mg Tablet Ritalin Gastrointestinal disturbances, skin reactions, anticonvulsants, tricyclic antidepressants,
disorder) discontinue if no response after 1 month, also suspend treatment. Careful supervision during drug arrythmias, severe angina pectoris,
fever, arthralgia. Rare: blurred vision, moderately phenylbutazone, guanethidine
periodically to assess child's condition (usually finally withdrawal. Children less than 6 years. Pregnancy hypersensitivity to drug/class, children less than
reduced weight gain and minor growth
discontinued during or after puberty) and lactation. Caution in road/machinery users. 6 years of age, MAOIs use within 14 days
retardation in children. Seizures, dependency,
Cardiovascular disease, alcohol/drug abuse,
leucopenia
hyperthyroidism
Onset or exacerbation of motor and verbal tics,
growth suppression with long-term therapy,
preexisting gastrointestinal narrowing or with
CHILD over 6 years: Individualize dosage, to be taken
dysphagia, severe depression and fatigue, may
once daily in the morning. Dose may be adjusted in
exacerbate symptoms of behavior disturbance and Loss of appetite, slurred speech, abnormal Marked anxiety, tension, agitation, glaucoma,
increments to a maximum of 54 mg/day, at weekly Pressor agents, MAOIs, anticoagulants,
Methylphenidate HCl 18 mg Extended- thought disorder in psychotic patients, patients behavior, restlessness, hypertension, Tourette's syndrome. Treatment with MAOIs or
Concerta Attention deficit hyperactivity disorder (ADHD) interval. Patient new to methylphenidate: starting dose anticonvulsants, tricyclic antidepressants,
release Tablet whose underlying conditions may be compromised tachyarrhythmia, thrombocytopenia, within a minimum of 14 days following
18 mg once daily. Patient currently using phenylbutazone, guanethidine
by increases in blood pressure or heart rate, history hallucinations discontinuation of a MAOI. Child less than 6 year
methylphenidate: 18 - 36 mg. Maximum 54 mg/day.
of drug dependence or alcoholism and seizures.
Discontinue if no response after 1 month
Periodic hematologic monitoring during prolonged
therapy. Pregnancy and lactation. May impair ability
to drive or operate machinery
May exacerbate behavioural disturbance and
Nervousness, insomnia, decreased appetite,
thought disorder in psychotic patients. Chronic
rash, arrhythmias, blurred vision, angina
abuse can lead to marked tolerance and psychic Anxiety and tension states, agitation, tics, tics in
pectoris, hepatic dysfunction, cerebral arteritis, Pressor agents, MAOIs, anticoagulants,
Methylphenidate HCl 20 mg LA 20 mg once daily to be taken in the morning. Dosage dependence. Epilepsy and hypertension. siblings, familial history or diagnosis of Tourette's
Ritalin LA Attention deficit hyperactivity disorder (ADHD) blood dyscrasias, thrombocytopenic purpura, anticonvulsants, tricyclic antidepressants,
Capsule be adjusted in increments to a maximum of 60 mg/day Emotionally unstable patients. Monitor blood syndrome, hyperthyroidism, cardiac arrhythmias,
exfoliative dermatitis, erythema multiforme, phenylbutazone, guanethidine
pressure during long-term treatment. Careful severe angina pectoris, glaucoma, lactation
choreoathetoid movements, tics, convulsions,
supervision during drug withdrawal. Children less
toxic psychosis, hallucinations
than 6 year. Pregnancy and lactation
Onset or exacerbation of motor and verbal tics,
growth suppression with long-term therapy,
preexisting gastrointestinal narrowing or with
CHILD over 6 years: Individualize dosage, to be taken
dysphagia, severe depression and fatigue, may
once daily in the morning. Dose may be adjusted in
exacerbate symptoms of behavior disturbance and Loss of appetite, slurred speech, abnormal Marked anxiety, tension, agitation, glaucoma,
increments to a maximum of 54 mg/day, at weekly Pressor agents, MAOIs, anticoagulants,
Methylphenidate HCl 36 mg Extended- thought disorder in psychotic patients, patients behavior, restlessness, hypertension, Tourette's syndrome. Treatment with MAOIs or
Concerta Attention deficit hyperactivity disorder (ADHD) interval. Patient new to methylphenidate: starting dose anticonvulsants, tricyclic antidepressants,
release Tablet whose underlying conditions may be compromised tachyarrhythmia, thrombocytopenia, within a minimum of 14 days following
18 mg once daily. Patient currently using phenylbutazone, guanethidine
by increases in blood pressure or heart rate, history hallucinations discontinuation of a MAOI. Child less than 6 year
methylphenidate: 18 - 36 mg. Maximum 54 mg/day.
of drug dependence or alcoholism and seizures.
Discontinue if no response after 1 month
Periodic hematologic monitoring during prolonged
therapy. Pregnancy and lactation. May impair ability
to drive or operate machinery
May exacerbate behavioural disturbance and
Nervousness, insomnia, decreased appetite,
thought disorder in psychotic patients. Chronic
rash, arrhythmias, blurred vision, angina
abuse can lead to marked tolerance and psychic Anxiety and tension states, agitation, tics, tics in
pectoris, hepatic dysfunction, cerebral arteritis, Pressor agents, MAOIs, anticoagulants,
Methylphenidate HCl 40mg LA 20 mg once daily to be taken in the morning. Dosage dependence. Epilepsy and hypertension. siblings, familial history or diagnosis of Tourette's
Ritalin LA Attention deficit hyperactivity disorder (ADHD) blood dyscrasias, thrombocytopenic purpura, anticonvulsants, tricyclic antidepressants,
Capsule be adjusted in increments to a maximum of 60 mg/day Emotionally unstable patients. Monitor blood syndrome, hyperthyroidism, cardiac arrhythmias,
exfoliative dermatitis, erythema multiforme, phenylbutazone, guanethidine
pressure during long-term treatment. Careful severe angina pectoris, glaucoma, lactation
choreoathetoid movements, tics, convulsions,
supervision during drug withdrawal. Children less
toxic psychosis, hallucinations
than 6 year. Pregnancy and lactation
Decreased effect: Phenytoin, phenobarbital,
rifampicin increases clearance of
Suppression of inflammatory and allergic disorders,
Fluid and electrolyte disturbances, muscle methylprednisolone. Potassium depleting
Methylprednisolone Sodium Succinate cerebral oedema, immunosuppression treatment of 15 - 30 mg/kg daily. Large doses may be repeated 4 - 6 Discontinue treatment by reducing the dosage
Solu-Medrol weakness, peptic ulcer, osteoporosis, abdominal Hypersensitivity, systemic fungal infection diuretics enhance potassium depletion.
0.5 g Injection haematological and oncological disorders, treatment of hourly for up to 48 hours gradually
distention, nausea and vomiting Increased toxicity: Skin test antigens,
shock states and endocrine disorders
immunizations decrease response of
methylprednisolone
Decreased effect: Phenytoin, phenobarbital,
rifampicin increases clearance of
Suppression of inflammatory and allergic disorders,
Fluid and electrolyte disturbances, muscle methylprednisolone. Potassium depleting
Methylprednisolone Sodium Succinate cerebral oedema, immunosuppression treatment of 15 - 30 mg/kg daily. Large doses may be repeated 4 - 6 Discontinue treatment by reducing the dosage
Solu-Medrol weakness, peptic ulcer, osteoporosis, abdominal Hypersensitivity, systemic fungal infection diuretics enhance potassium depletion.
1 g Injection haematological and oncological disorders, treatment of hourly for up to 48 hours gradually
distention, nausea and vomiting Increased toxicity: Skin test antigens,
shock states and endocrine disorders
immunizations decrease response of
methylprednisolone
Hepatic and renal impairment, elderly, young adults
Extrapyramidal effects (especially in children and
i) ADULT over 20 years: 10 mg 3 times daily. ADULT and children; may mask underlying disorders such
young adults), hyperprolactinaemia, tardive Concomitant therapy with drugs which are likely Increased absorption of aspirin and paracetamol;
i) Dyspepsia, flatulence, hiatus hernia, peptic between 12 - 20 years: 5 mg 3 times daily. CHILD as cerebral irritation; avoid for 3 - 4 days following
dyskinesia, drowsiness, restlessness, anxiety, to cause extrapyramidal reactions, epileptics, opioid analgesics and antimuscarinics
ulceration, reflux oesophagitis, gastritis, duodenitis, under 12 years: 0.12 mg/kg/dose 6 - 12 hourly ii) Single gastro-intestinal surgery, may cause acute
Metoclopramide HCl 10 mg Tablet Maxolon drowsiness, fatigue, akathisia, insomnia, gastrointestinal haemorrhage, obstruction antagonise effect on gastro-intestinal activity,
cholelithiasis, nausea, vomiting ii) Promote bowel dose 5 - 10 minutes before examination; ADULT and hypertensive response in phaeochromocytoma;
depression, neuroleptic malignant syndrome, (mechanical), or perforation, hypersensitivity to antipsychotics (increased risk of extrapyramidal
transit during diagnostic procedures CHILD over 15 years: 10 - 20 mg; CHILD less than 15 pregnancy and breast feeding; porphyria. Use
diarrhoea, bronchospasm and cardiac metoclopramide, pheochromocytoma effects). Decrease absorption of digoxin
years: 0.12 mg/kg/dose 6 - 12 hourly cautiously in patients with depression, Parkinson's
conduction abnormalities
disease or hypertension
Extrapyramidal effects (especially in children and
i) ADULT over 20 years: 10 mg 3 times daily. ADULT and children; may mask underlying disorders such
young adults), hyperprolactinaemia, tardive Concomitant therapy with drugs which are likely Increased absorption of aspirin and paracetamol;
i) Dyspepsia, flatulence, hiatus hernia, peptic between 12 - 20 years: 5 mg 3 times daily. CHILD as cerebral irritation; avoid for 3 - 4 days following
dyskinesia, drowsiness, restlessness, anxiety, to cause extrapyramidal reactions, epileptics, opioid analgesics and antimuscarinics
Metoclopramide HCl 10 mg/2 ml ulceration, reflux oesophagitis, gastritis, duodenitis, under 12 years: 0.12 mg/kg/dose 6 - 12 hourly ii) Single gastro-intestinal surgery, may cause acute
Maxolon drowsiness, fatigue, akathisia, insomnia, gastrointestinal haemorrhage, obstruction antagonise effect on gastro-intestinal activity,
Injection cholelithiasis, nausea, vomiting ii) Promote bowel dose 5 - 10 minutes before examination; ADULT and hypertensive response in phaeochromocytoma;
depression, neuroleptic malignant syndrome, (mechanical), or perforation, hypersensitivity to antipsychotics (increased risk of extrapyramidal
transit during diagnostic procedures CHILD over 15 years: 10 - 20 mg; CHILD less than 15 pregnancy and breast feeding; porphyria. Use
diarrhoea, bronchospasm and cardiac metoclopramide, pheochromocytoma effects). Decrease absorption of digoxin
years: 0.12 mg/kg/dose 6 - 12 hourly cautiously in patients with depression, Parkinson's
conduction abnormalities
disease or hypertension
Increased absorption of aspirin, paracetamol,
tetracycline, levodopa, ethanol, cyclosporine,
and children; may mask underlying disorders such Extrapyramidal effects (especially in children and
i) CHILD over 5 years: 2.5 - 5 ml 3 times daily. 3 - 5 opioid analgesics and antimuscarinics
as cerebral irritation; avoid for 3 - 4 days following young adults), hyperprolactinaemia, tardive Concomitant therapy with drugs which are likely
i) Dyspepsia, flatulence, hiatus hernia, peptic years 2 ml 2 - 3 times daily. 1 - 3 years: 1 ml 2 - 3 times antagonise effect on gastro-intestinal activity,
gastrointestinal surgery, may cause acute dyskinesia, drowsiness, restlessness, anxiety, to cause extrapyramidal reactions, epileptics,
ulceration, reflux oesophagitis, gastritis, duodenitis, daily. Under 1 year: 1 ml 2 times daily ii) Single dose antipsychotics (increased risk of extrapyramidal
Metoclopramide HCl 5 mg/5 ml Syrup Maxolon hypertensive response in phaeochromocytoma, drowsiness, fatigue, akathesia, insomnia, gastrointestinal haemorrhage, obstruction
cholelithiasis, nausea, vomiting ii) Promote bowel given 10 minutes before examination. CHILD over 5 effects). Decrease absorption of digoxin,
pregnancy and breast feeding, porphyria. Use depression, neuroleptic malignant syndrome, (mechanical), or perforation, hypersensitivity to
transit during diagnostic procedures years: 2.5 - 5 ml. Between 3 - 5 years: 2 ml. Under 1 antagonized by anticholinergic drugs and
cautiously in patients with depression, Parkinson's diarrhoea, bronchospasm and cardiac metoclopramide, pheochromocytoma
year: 1 ml narcotic analgesics. Additive sedative effects
disease or hypertension, insulin dosage or timing of conduction abnormalities
with alcohol, sedatives, hypnotics, narcotics or
dosage may require adjustment
tranquilizers
Avoid concomitant lithium. Diabetics may require
increased amounts of insulin or oral hypoglycaemic
agents. Electrolyte imbalance (eg, hypokalaemia,
hyponatraemia, hypomagnesaemia), hepatic
Angiotensin converting enzyme inhibitors,
Oedema in congestive cardiac failure, nephrotic ADULT: 5 - 20 mg 4 times daily. CHILD: 0.05 -0.1 disease, hyperuricaemia, lupus erythematosus. May Dizziness, orthostatic hypotension, oedema, Anuria, hepatic coma or pre-coma and
Metolazone 2.5 mg Tablet Diulo calcium carbonate, diazoxide, digitalis
syndrome and impaired renal function mg/kg 4 times daily aggravate digitalis toxicity. May potentiate the effects hypokalaemia, rash, cough, nausea, vomiting hypersensitivity to metolazone
glycosides, lithium
of other antihypertensives. Orthostatic hypotension,
severe renal disease (may precipitate azotemia),
sensitivity reactions may occur with or without a
history of allergy or asthma

Hypertension: Initially 100 mg to maximum 400 mg Hypersensitivity to metoprolol products,
chlorpromazine, chlorprothixene, cimetidine,
Lassitude, gastrointestinal and sleep pattern
Hypertension, angina, myocardial infarction, daily, Angina: 50 mg - 100 mg in 2 - 3 times daily. bradycardia, 2nd and 3rd degree AV block overt
clonidine, digoxin, dihydropyridine, calcium
Metoprolol Tartrate 100 mg Tablet Betaloc Pregnancy, lactation disturbances; rarely, non-specific skin reactions
arrhythmias Myocardial infarction: 200 mg daily in divided doses. cardiac failure, cardiogenic shock, obstructive
channel blockers, flunarizine, fluoxetine,
and coldness of extremities
Arrythmias: 50 mg - 300 mg in 2 - 3 times daily pulmonary disease fluvoxamine, hydralazine, hypoglycemic agents,
lidocaine, methyldopa
Hypertension: Initially 100 mg to maximum 400 mg Hypersensitivity to metoprolol products, chlorpromazine, chlorprothixene, cimetidine,
Lassitude, gastrointestinal and sleep pattern
Hypertension, angina, myocardial infarction, daily, Angina: 50 mg - 100 mg in 2 - 3 times daily. bradycardia, 2nd and 3rd degree AV block overt clonidine, digoxin, dihydropyridine, calcium
Metoprolol Tartrate 50 mg Tablet Betaloc Pregnancy, lactation disturbances; rarely, non-specific skin reactions
arrhythmias Myocardial infarction: 200 mg daily in divided doses. cardiac failure, cardiogenic shock, obstructive channel blockers, flunarizine, fluoxetine,
and coldness of extremities
Arrythmias: 50 mg - 300 mg in 2 - 3 times daily pulmonary disease fluvoxamine, hydralazine, hypoglycemic agents,
lidocaine, methyldopa
Gastrointestinal disturbances, urticaria,
ADULT: 1 g rectally 8 hourly for 3 days, then 1 g 12 angioedema, drowsiness, dizziness, headache,
hourly if treatment must continue (not more than 7 ataxia, skin rashes, pruritus, darkening of urine.
Alcohol, warfarin, phenobarbitone, lithium,
days). CHILD up to 1 year: 125 mg every 8 hours for 3 Peripheral neuropathy or transient epileptiform
phenytoin, cimetidine, amiodarone, busulfan,
days, then every 12 hours. CHILD 1 - 5 years: 250 mg. Caution in patient with active disease of CNS except seizures (prolonged therapy), leucopenia. Hypersensitivity to metronidazole. Chronic
Metronidazole 0.5 g Suppository Flagyl Anaerobic infection carbamazepine, cholestyramine, cyclosporine,
CHILD 5 - 10 years: 500 mg. Prophylaxis: More than 12 for brain abscess of hepatic encephalopathy Nausea, vomiting, unpleasant metallic taste, alcohol dependence
dihydroergotamine, disulfiram, ergotamine,
years: 1 g rectally 2 hours before surgery, up to 3 furred tongue and erythema multiforme,
fluorouracil, tacrolimus
further doses of 1 g may be given every 8 hours for angioedema, hepatitis, jaundice,
high-risk procedure thrombocytopenia, aplastic anaemia, myalgia,
arthralgia
Unpleasant taste in mouth, furry tongue,
gastrointestinal disturbances, urticaria,
angioedema, drowsiness, dizziness, headache, Alcohol, warfarin, phenobarbitone, lithium,
Caution in patient with active disease of CNS except ataxia, skin rashes, pruritus, darkening of urine, phenytoin, cimetidine, amiodarone, busulfan,
800 mg initially followed by 400 mg 8 hourly. CHILD: Hypersensitivity to metronidazole. Chronic
Metronidazole 200 mg Tablet Flagyl Anaerobic infection for brain abscess or hepatic encephalopathy. peripheral neuropathy or transient epileptiform carbamazepine, cholestyramine, cyclosporine,
7.5 mg/kg every 8 hours alcohol dependence
Pregnancy and lactation seizures, leucopenia, nausea, vomiting, dihydroergotamine, disulfiram, ergotamine,
erythema multiforme, hepatitis, jaundice, fluorouracil, tacrolimus
thrombocytopenia, aplastic anaemia, myalgia,
arthralgia
Unpleasant taste in mouth, furry tongue,
gastrointestinal disturbances, urticaria,
angioedema, drowsiness, dizziness, headache, Alcohol, warfarin, phenobarbitone, lithium,
ataxia, skin rashes, pruritus, darkening of urine, phenytoin,c imetidine, amiodarone, busulfan,
Metronidazole 200 mg/5 ml Caution in patient with active disease of CNS except Hypersensitivity to metronidazole. Chronic
Flagyl Anaerobic infection CHILD: 7.5 mg/kg 3 times daily for 7 days peripheral neuropathy or transient epileptiform carbamazepine, cholestyramine, cyclosporine,
Suspension for brain abscess of hepatic encephalopathy alcohol dependence
seizures ,leucopenia, nausea, vomiting, dihydroergotamine, disulfiram, ergotamine,
erythema multiforme, angioedema, hepatitis, fluorouracil, tacrolimus
jaundice, thrombocytopenia, aplastic anaemia,
myalgia, arthralgia
If administered for more than 10 days,
GI disturbances, urticaria, angioedema, Alcohol, warfarin, phenobarbitone, lithium,
haematological tests are recommended. Re-
drowsiness, dizziness, headache, ataxia, skin phenytoin, cimetidine, amiodarone, busulfan,
Metronidazole 500 mg/100 ml ADULT: 500 mg IV infusion 8 hourly. CHILD: 7.5 mg/kg administer immediately after haemodialysis. Caution
Metrogyl Anaerobic infections rashes, pruritus, darkening of urine, peripheral Hypersensitivity to metronidazole carbamazepine, cholestyramine, cyclosporine,
Injection body weight every 8 hours in patient with active disease of CNS except for brain
neuropathy or transient epileptiform seizures, dihydroergotamine, disulfiram, ergotamine,
abscess or hepatic encephalopathy. Pregnancy &
leucopenia, anaphylaxis fluorouracil, tacrolimus
lactation
i) Fungal infections: Tinea pedis, Tinea corporis, Tinea
i) Skin Infection: Apply sparingly and rub gently onto
capitis and other dermatophyte infections caused by
affected area 1-2 times daily continuing for 10 days First trimester of pregnancy, lactation. Local Ocassional skin irritation or sensitivity, contact Children less than 2 year. Hypersensitivity to
Miconazole 2% Cream Daktarin Trichophyton and Epidermophyton species ii) Not known
after lesions have healed ii) Apply twice daily continuing sensitization or irritation, to discontinue use dermatitis, vaginal burning due to cream base manizole products
Antifungal agent that has been in various candida
for 10 days after lesions have healed
infections including vaginal candidiasis
Miconazole Nitrate 2% Powder Daktarin Skin infections caused by dermatophytes or Candida Dust powder over infected area 1 - 2 times daily First trimester of pregnancy, lactation Ocassional skin irritation or sensitivity Children less than 2 years Not known
Usual sedative range 2.5 - 7.5 mg (about 70 mcg/kg by Neuroleptics, tranquilizer, antidepressant,
Elderly, COPD, congestive heart failure, respiratory
IV injection over 30 seconds). Premedication by IM Muscle stiffness, induration of veins, pain, hypnotics, analgesics, anaesthetics,
failure, severe electrolyte and fluid disturbances,
injection 70 - 100 mcg/kg 30 -60 minutes before redness, headache, apnoea, nausea, coughing, antipsychotics, anxiolytics, antiepiletics,
Pre-operative sedation, induction of general pregnancy and lactation, hepatic and renal Acute narrow angle glaucoma, hypersensitivity to
surgery; ELDERLY: 1 - 1.5 mg/kg. Induction: Induction vomitting, drowsiness, respiratory depression, antihistamines, erythromycin, clarithromycin,
Midazolam 5 mg/5 ml Injection Dormicum anaesthesia, premedication and sedation in ICU and impairment, labor and delivery, prolonged use and midazolam products, acute alcohol intoxication,
by slow IV infusion 200 - 300 mcg/kg (ELDERLY 100 - phlebitis, gastrointestinal disturbances, cimetidine, omeprazole, diltiazem, efavirenz,
sedation for minor procedures abrupt withdrawal, moderate lowering of intraocular shock, lactation
200 mcg/kg. CHILD over 7 years 150 - 200 mcg/kg); increased appetite, jaundice, hypotension, indinavir, nelfinavir, ritonavir, saquinavir,
pressure in ophthalmic. Children under 15 kg not to
Maximum: 0.35mg/kg. Sedation in ICU 0.03 - 0.2 bronchospasm, pain at the site of injection fluvoxamine, halothane, sevoflurane, thiopental,
exceed 1 mg/ml
mg/kg/hour itraconazole, theophylline, atorvastatin
Usual sedative range 2.5 - 7.5 mg (about 70 mcg/kg by Neuroleptics, tranquilizer, antidepressant,
IV injection over 30 seconds). Premedication by IM Muscle stiffness, induration of veins, pain, hypnotics, analgesics, anaesthetics,
injection 70 - 100 mcg/kg 30 -60 minutes before redness, headache, apnoea, nausea, coughing, antipsychotics, anxiolytics, antiepiletics,
Pre-operative sedation, induction of general pregnancy and lactation, hepatic and renal Acute narrow angle glaucoma, hypersensitivity to
surgery; ELDERLY: 1 - 1.5 mg/kg. Induction: Induction vomitting, drowsiness, respiratory depression, antihistamines, erythromycin, clarithromycin,
Midazolam 5 mg/ml Injection Dormicum anaesthesia, premedication and sedation in ICU and impairment, labor and delivery, prolonged use and midazolam products, acute alcohol intoxication,
by slow IV infusion 200 - 300 mcg/kg (ELDERLY 100 - phlebitis, gastrointestinal disturbances, cimetidine, omeprazole, diltiazem, efavirenz,
sedation for minor procedures abrupt withdrawal, moderate lowering of intraocular shock, lactation
200 mcg/kg. CHILD over 7 years 150 - 200 mcg/kg); increased appetite, jaundice, hypotension, indinavir, nelfinavir, ritonavir, saquinavir,
Maximum: 0.35mg/kg. Sedation in ICU 0.03 - 0.2 bronchospasm, pain at the site of injection fluvoxamine, halothane, sevoflurane, thiopental,
exceed 1 mg/ml
mg/kg/hour itraconazole, theophylline, atorvastatin
Neuroleptics, tranquilizer, antidepressant,

Muscle stiffness, induration of veins, pain, hypnotics, analgesics, anaesthetics,
ADULT: Usually 7.5 - 15 mg at bedtime; or for redness, headache, apnoea, nausea, coughing, antipsychotics, anxiolytics, antiepiletics,
pregnancy and lactation, hepatic and renal Acute narrow angle glaucoma, hypersensitivity to
premedication, 30 - 60 minutes before the procedure. vomitting, drowsiness, respiratory depression, antihistamines, erythromycin, clarithromycin,
Midazolam 7.5 mg Tablet Dormicum Pre and post-operative sedation impairment, labor and delivery, prolonged use and midazolam products, acute alcohol intoxication,
For ELDERLY, debilitated or impaired liver/kidney phlebitis, gastrointestinal disturbances, cimetidine, omeprazole, diltiazem, efavirenz,
abrupt withdrawal, moderate lowering of intraocular shock, lactation
function: 7.5 mg increased appetite, jaundice, hypotension, indinavir, nelfinavir, ritonavir, saquinavir,
bronchospasm, pain at the site of injection fluvoxamine, halothane, sevoflurane, thiopental,
exceed 1 mg/ml
itraconazole, theophylline, atorvastatin
Overgrowth of susceptible organisms, renal
GI disorders, dizziness, vertigo, maculopapular
impairment. Use in conjunction with penicillins. Hypersensitivity to tetracycline. Last half of Oral absorption is impaired by antacids
Minocycline 100 mg Capsule Minocin As second-line treatment for leprosy only 100 mg daily 6 - 18 months and erythematous rashes, photosensitivity, tooth
Autoimmune syndromes, risk of impaired pregnancy, infants, children 8 years or less containing Al, Mg
discoloration, hypersensitivity reactions
spermatogenesis
Overgrowth of susceptible organisms, renal
GI disorders, dizziness, vertigo, maculopapular
impairment. Use in conjunction with penicillins. Hypersensitivity to tetracycline. Last half of Oral absorption is impaired by antacids
Minocycline 50 mg Capsule Minocin As second-line treatment for leprosy only 100 mg daily 6 - 18 months and erythematous rashes, photosensitivity, tooth
Autoimmune syndromes, risk of impaired pregnancy, infants, children 8 years or less containing Al, Mg
discoloration, hypersensitivity reactions
spermatogenesis
ADULTS and CHILD above 12 years old: Initially 5 mg Angina pectoris, breast feeding, cerebrovascular Salt and water retention, tachycardia, pericardial
daily in single or divided doses (elderly 2.5 mg). May disease, cerebrovascular accident (recent), effusion and tamponad, hypertrichosis.
Combination with guanethidine may produce
Minoxidil 5 mg Tablet Loniten Severe hypertension increase by 5 - 10 mg daily at intervals of 3 or more congestive heart failure (without adequate diuretic Occasionally; allergic rashes, gastrointestinal Hypersensitivity to minoxidil products
orthostatic hypotension
days until optimum control is achieved. Maximum 50 therapy), dialysis, fluid retention, impaired renal effects, breast tenderness, thrombocytopenia,
mg daily function, myocardial infarction leucopenia
Agranulocytopenia, neutropenia, mania,
dizziness, increase appetite, constipation,
somnolence. Patients should be advised to
report any fever, sore throat, stomatitis or other Clonidine, monoamine oxidase inhibitors,
Heart disease, hypotension, epilepsy, hepatic and
Initially 15 mg daily at bedtime increased according to signs of infection during treatment. Blood count ethanol, warfarin, carbamazepine, phenytoin,
renal impairment, pregnancy, mania and hypomania,
Mirtazapine 15 mg Orodispersible response up to 45 mg daily as a single dose at bedtime should be performed and the drug stopped Hypersensitivity to mirtazapine or component of ketoconazole, cimetidine, methadone, rifampicin,
Episodes of major depression hypersensitivity to other anti-depressant, suicidal
Tablet or in 2 divided doses. CHILD and ADOLESCENT under immediately if blood dyscrasia suspected, formulation, MAOIs, procarbazine, selegiline antivirals, St. John's wort, diazepam, fluoxetine,
ideation and behavior or worsening depression;
18 years not recommended increased appetite, raised serum cholesterol and fluvoxamine, linezolid, olanzapine, tramadol,
increased risk in children and adolescents
serum triglycerides, raised ALT (SGPT) level, venlafaxine
asthenia, dizziness, dream disorder,
agranulocytosis, neutropenia, seizure, worsening
depression, suicidal ideation
Agranulocytopenia, neutropenia, mania,
dizziness, increase appetite, constipation,
somnolence. Patients should be advised to
report any fever, sore throat, stomatitis or other Clonidine, monoamine oxidase inhibitors,
Heart disease, hypotension, epilepsy, hepatic and
Initially 15 mg daily at bedtime increased according to signs of infection during treatment. Blood count ethanol, warfarin, carbamazepine, phenytoin,
renal impairment, pregnancy, mania and hypomania,
Mirtazapine 30 mg Orodispersible response up to 45 mg daily as a single dose at bedtime should be performed and the drug stopped Hypersensitivity to mirtazapine or component of ketoconazole, cimetidine, methadone, rifampicin,
Episodes of major depression hypersensitivity to other anti-depressant, suicidal
Tablet or in 2 divided doses. CHILD and ADOLESCENT under immediately if blood dyscrasia suspected, formulation, MAOIs, procarbazine, selegiline antivirals, St. John's wort, diazepam, fluoxetine,
ideation and behavior or worsening depression;
18 years not recommended increased appetite, raised serum cholesterol and fluvoxamine, linezolid, olanzapine, tramadol,
increased risk in children and adolescents
serum triglycerides, raised ALT (SGPT) level, venlafaxine
asthenia, dizziness, dream disorder,
agranulocytosis, neutropenia, seizure, worsening
depression, suicidal ideation
Elderly patients, previous cytotoxic or radiation Chronic hypotony, sometimes associated with Hypersensitivity to any component of this
Mitomycin C 0.002% Eye Drops Pterygium, conjunctival tumour, glaucoma surgery 1 - 2 drops several times a day Not known
therapy, hepatic and renal disorders maculopathy and irreversible visual loss products
Mitomycin C 0.02% Eye Drops - Pterygium, conjunctival tumour, glaucoma surgery 1 - 2 drops several times a day Not known
Mitomycin C 0.04% Eye Drops Pterygium, conjunctival tumour, glaucoma surgery 1 - 2 drops several times a day Not known
i) 10 - 20 mg/m2 body surface area (BSA) given as a
i) Gastrointestinal, lung, breast, cervical cancers ii)
single dose through a running IV infusion repeated Nephrotoxicity, delayed myelosuppression,
Bladder tumours iii) Opthalmological conditions:
every 6 - 8 weeks. The whole schedule may be Bleeding tendency, radiotherapy, extravasation, nausea and vomiting, alopecia, congestive heart Thrombocytopenia, coagulation disorders, Vinblastine, vince alkaloids may increase risk of
conjunctival squamous neoplasia, squamous cell
Mitomycin-C 10 mg Injection Mitomycin-C repeated depending on the bone marrow ii) 10 - 40 mg hepatic dysfunction, myelosuppression, renal failure, fever, haemolytic uraemic syndrome-risk pregnancy, lactation, hypersensitivity to cardiotoxicity when given together with
carcinoma of conjunctiva, trabeculectomy chronic
daily or every other day (intravesical) iii) 0.4 mg impairment increase when cumulative dose more than 50 mitomycin, hepatotoxicty mitomycin C
lymphocytic leukaemia, chronic myelogenous
topically as a single application for opthalmological mg/m2, interstitial pneumonitis
leukaemia. Gastric, colorectal, lung cancer
conditions, duration: 1 to 3 minutes
Myelosuppression, nausea, vomiting, stomatitis,
10 - 12 mg/m2 IV daily for 3 days, in combination with
alopecia, hepatotoxicity, congestive cardiac
other cytotoxic agents. Refer to protocol. CHILD: 5 - 10 Myelosuppression or poor general condition in cases
failure, constipation, diarrhoea, arrhythmias,
Acute leukaemia, elderly patients with acute myeloid mg/m2 daily for 3 - 5 days according to protocol. with functional cardiac changes including congestive Hypersensitivity to mitoxantrone products,
discolouration of urine and other secretions, Increased risk of infection by the live vaccine,
Mitoxantrone 20 mg/10ml Injection Novantrone leukaemia (AML), relapsed/resistant acute leukaemia, Treatment of acute leukaemia, ADULT: 8 - 12 heart failure and decrease in left ventricular ejection pregnancy, lactation, severe myelosuppression,
alopecia, secondary malignancy, fatigue, fever, trastuzumab
non-Hodgkin's lymphoma (NHL) mg/m2/day once daily for 4 - 5 days. CHILD more than fraction, hepatic insufficiency, children, pregnancy, cardiac dysfunction
headache, amenorrhoea, abdominal pain, acute
2 years: same as adult dose. CHILD 2 years: 0.4 lactation
myeloid leukaemia, myelodysplasia of the spinal
mg/kg/day once daily for 3 - 5 days
cord
Mixed Gas-Gangrene Antitoxin 25,000 Prophylactic: 25,000 units IM or IV. Therapeutic: Not Anaphylaxis and serum sickness if source is
- Mixed gas-gangrene Not known Not known Not known
units/5 ml Injection less than 75,000 units IV equine
Avoid in excited and agitated patient,
thyorotoxicosis, hepatic impairment, pregnancy, Sleep disturbance, dizziness, gastrointestinal
Acute confusional state, hypersensitivity to
Initially 300 mg daily in divided doses. Gradually to lactation, hypertensive, avoid ingestion of excessive disturbance, restlessness, agitation, blurred
moclobemide, concomitant use with selective
increase up to 600 mg daily in divided doses depending amounts of tyramine-rich foods, occipital headache, vision, dry mouth, headache, constipation, Tricyclic antidepressants, beta-2 agonist,
Moclobemide 150 mg Tablet Aurorix Treatment of depressive syndrome serotonin reuptake inhibitors, conventional
on response. Usual range 150 - 600 mg daily. Not palpitations, neck stiffness, tachycardia or possible hyponatraemia, diaphoresis, rash, carbamazepine
MAOIs or tricyclic antidepressants, concomitant
recommended in children bradycardia, coadministration with increase libido, abdominal pain, hepatotoxicity,
use of narcotics
dextromethorphan resulted in vertigo, tremor, oedema, orthostatic hypotension, tremor
nausea and vomiting
For primary volume replacement in hypovolaemia, peri-
operative stabilization of the circulation, haemodilution,
Modified Fluid Gelatin 4% Injection Gelafusine ADULT 500 - 1500 ml given as IV infusion Patients with cardiac disease Hypersensitivity reactions, severe anaphylactoid Not known Not known
extracorporeal circulation (haemodialysis and heart-
lung machine)
For primary volume replacement in hypovolaemia, peri-
Modified Polypeptides (Polygeline) operative stabilization of the circulation, haemodilution,
Haemacel ADULT 500 - 1500 ml given by IV infusion Patients with cardiac disease Hypersensitivity reactions, severe anaphylactoid Not known Not known
3.5% Injection extracorporeal circulation (haemodialysis and heart-
lung machine)
Pre-existing pulmonary disease, autoimmune
disease, children under 18 years of age, granulocyte-
i) As secondary prophylaxis and therapeutic use
SC or IV 250 mcg/m2/day. Initiation: 24 to 72 hours macrophage colony-stimulating factor (GM-CSF) Fever, gastrointestinal disturbances, dyspnoea,
against chemotherapy induced leucopenia according to Bleomycin, cyclosphosphamide, ifosphamide,
Molgramostim 300 mcg Injection Leucomax after chemotherapy. Duration: Until a clinically reduces the myelotoxicity but not the overall toxicity rash, fatigue, musculoskeletal pain, bone pain, Myeloid malignancies, pregnancy
clinician's discretion ii) Haemopoietic stem cell topotecan
adequate neutrophil recovery is achieved of chemotherapy drugs, therefore its use for chills, asthenia, loss of appetite
transplantation (HSCT)
increasing chemotherapy dose intensity is not
recommended
Systemic absorption may be increased if extensive
Steroid responsive dermatosis and vitiligo. Used where
Apply once daily to affected areas. Do not use in body surface are treated. Do not use occlusive Burning, pruritus, skin atrophy, paraesthesia, Hypersensitivity to mometasone or any
Mometasone Furoate 0.1% Cream Elomet a potent steroid is required for short duration not more CYP3A4
paediatric patients for longer than 3 weeks dressing. Long term use in infant and children. Avoid tingling or stinging component of the formulation
than 6 weeks
contact with eyes, pregnancy, lactation
Presence of untreated localized infection involving

Severe nasal infections especially candidiasis,
the nasal mucosa, recent nasal surgery or trauma,
ADULT and CHILD over 12 years: 100 mcg/day (2 patients with haemorrhagic diathesis or a history
pregnancy, infection e.g. tuberculosis, infection of CYP3A4, amphotericin, antidiabetic agents,
sprays) to each nostril once daily. Maximum 200 mcg Headache, pharyngitis, cough epistaxis, viral of recurrent nasal bleeding, fungal, viral or
Mometasone Furoate 50 mcg the respiratory tract, untreated systemic fungal, antifungal agents (imidazole), diuretics,
Nasonex Allergic rhinitis (4 sprays) once daily. Reduce to 50 mcg (1 spray) once infection, chest pain, dysmenorrhoea, vomiting, tubercular skin lesions, herpes simplex or zoster,
Aqueous Nasal Spray bacterial, viral or parasitic infections or ocular herpes potassium-wasting (loop or thiazide),
daily when control achieved. CHILD 6 - 12 years old: 50 nausea, diarrhoea, dyspepsia hypersensitivity to mometasone or other
simplex, systemic effects e.g. hypercorticism, fluoroquinolones
mcg (1 spray) to each nostril once daily corticosteroids, status asthmaticus or other acute
reduced bone mineral density and adrenal
episodes of asthma (oral inhalation)
suppression, untreated systemic infections
45 ml diluted with half a glass (120 ml) of water,

followed by one full glass (240 ml) of water to be taken
depending on the time of the procedure. For morning
Pregnancy, severe renal impairment, heart disease Salts of magnesium, aluminium and calcium will
procedure, 45 ml dilute with half glass of water should
(congestive cardiac failure, hypertension and Gastrointestinal obstruction, gastric retention, bind phosphate and reduce absorption. Vitamin
be taken at 7 am and the second 45 ml at 7 pm on the
Monobasic Sodium Phosphate 48%, Bowel cleansing prior to colonoscopy, radiological oedema), ulcerative colitis (Irritable Bowel Nausea and bloating, abdominal cramps, gastro-intestinal ulceration, perforated bowel, D will increase absorption of phosphate with
Fleet Phospho-soda day before the procedure. For afternoon procedure, the
Dibasic Sodium Phosphate 18% examination or bowel surgery Syndrome) reflux oesophagitis, preexisting vomiting congestive cardiac failure, toxic colitis, toxic diuretics and drugs affect serum electroytes may
first dose should be taken at 7 pm on the day before
electrolyte disturbances (low serum calcium megacolon or ileus induce hyperphosphataemia, hypocalaemia and
and the second dose at 7 am on the day of the
concentration, hyperkalaemia) hypernatraemia
procedure. Solid food must not be taken during the
preparation period; clear fluids or water can be taken
liberally. Not recommended for use in children
Should not be used for treatment of acute asthma
attacks. Should not be abruptly substituted for
Chronic treatment of asthma and relief of symptoms of inhaled or oral corticosteroids. Pregnancy and Abdominal pain, headache ,thirst, diarrhea,
CHILD more than 15 years and ADULT: 10 mg daily at Hypersensitivity to any component of
Montelukast Sodium 10 mg Tablet Singulair seasonal allergic rhinitis for children more than 15 lactation. Patients with known aspirin sensitivity hyperkinesia, flu-like symptoms, eczematous Phenobarbitone
bedtime montelukast
years and adults should continue avoidance of aspirin or NSAIDs dermatitis and rash
while taking montelukast. Paediatric less than 6
month
Asthmatics, not controlled on high dose inhaled inhaled or oral corticosteroids. Pregnancy and Abdominal pain, headache ,thirst, diarrhea,
Montelukast Sodium 4 mg Oral 12 months - 5 years: 1 packet of 4mg oral granules Hypersensitivity to any component of
Singulair corticosteroids more than 1600 mcg/day and with co- lactation. Patients with known aspirin sensitivity hyperkinesia, flu-like symptoms, eczematous Phenobarbitone
Granules daily at bedtime montelukast
morbid allergic disorders. Chronic treatment of asthma should continue avoidance of aspirin or NSAIDs dermatitis and rash
month
Asthmatics, not controlled on high dose inhaled inhaled or oral corticosteroids. Pregnancy and Abdominal pain, headache ,thirst, diarrhea,
Montelukast Sodium 5 mg Chewable CHILD 6 - 14 years: One 5 mg chewable tablet daily at Hypersensitivity to any component of
Singulair corticosteroids more than 1600 mcg/day and with co- lactation. Patients with known aspirin sensitivity hyperkinesia, flu-like symptoms, eczematous Phenobarbitone
Tablet bedtime montelukast
morbid allergic disorders. Chronic treatment of asthma should continue avoidance of aspirin or NSAIDs dermatitis and rash
month
Neonates, children, infants less than 3 months,
Constipation, nausea, vomiting, drowsiness, dry Raised intra-cranial pressure, respiratory
elderly, obstetric patients, chronic obstructive airway
mouth, psychomimetic effect (dysphoria, depression and biliary colic (these conditions are MAOIs: hypotension and exaggeration of CNS
disease, asthma; pregnancy, lactation, renal and
hallucination, nightmare), urinary retention, not contra-indicated in patients who are and respiratory depressant effects. Naltrexone:
For use in management of moderate to severe pain 5 - 20 mg or more regularly every 4 hours in terminal hepatic impairment, hypothyroidism, head injury,
Morphine HCl 10 mg/5 ml Solution - respiratory depression (rare). Convulsions; dry terminally ill). Hypersensitivity to morphine, acute precipitation of opioid withdrawal symptoms.
especially that associated with neoplastic disease pain intracranial lesions; hypotension, circulatory shock;
mouth, headache, vertigo; palpitations; or severe asthma; paralytic ileus; obstructive Cimetidine : morphine toxicity (CNS depression,
seizure-prone patients; adrenocortical insufficiency;
hypothermia; pruritus, urticaria; tachycardia, airway disease; acute liver disease; comatose respiratory depression)
prostatic hyperplasia; inflammatory or obstructive
bradycardia; blurred vision; miosis; dependency patients; pregnancy, acute alcoholism
bowel disease; myasthaenia gravis
Raised intra-cranial pressure, respiratory
depression and biliary colic (these conditions are
not contra-indicated in patients who are
MAOIs: hypotension and exaggeration of CNS
Constipation, nausea, vomiting, drowsiness, dry terminally ill). Hypersensitivity to morphine, acute
and respiratory depressant effects including
mouth, psychomimetic effect (dysphoria, or severe asthma; paralytic ileus; obstructive
Neonates, children, elderly, obstetric patients, sedatives or hypnotics, general anaesthetic,
Prolonged relief of severe pain associated with hallucination, nightmare), urinary retention, airway disease; acute liver disease; comatose
Morphine Sulphate 10 mg Controlled 10 - 60 mg 12 hourly intervals, depend upon the chronic obstructive airway disease, pregnancy, phenothiazines, other tranquillizers, muscle
MST Continus neoplastic disease; assists in procuring sleep where respiratory depression (rare). Convulsions; dry patients; pregnancy. acute alcoholism, head
Release Tablet severity of the pain lactation, renal and hepatic impairment, relaxants, antihypertensives, alcohol; respiratory
sleeplessness is due to pain or shock mouth, headache, vertigo; palpitations; injury, paralytic ileus, delayed gastric emptying,
hypothyroidism depression, cimetidine. Naltrexone: precipitation
hypothermia; pruritus, urticaria; tachycardia, obstructive airways disease, cardiac
of opioid withdrawal symptoms. Cimetidine:
bradycardia; blurred vision; miosis; dependency arrhythmias, acute hepatic disease; concurrent
morphine toxicity
MAOIs (or within 2 week). Not recommended for
pre-operation use or for the 1st 24 hour post-
operation. Pregnancy & lactation. Children
mouth, psychomimetic effect (dysphoria, depression and biliary colic (these conditions are
hallucination, nightmare), urinary retention, not contra-indicated in patients who are
Morphine Sulphate 10 mg Immediate 5-10 mg every four hours. The dose may be increased chronic obstructive airway disease, pregnancy, phenothiazines, other tranquillizers, muscle
Statex Relief of moderate to severe pain (cancer patient) respiratory depression (rare). Convulsions; dry terminally ill). Hypersensitivity to morphine, acute
Release Tablet according to needs lactation, renal and hepatic impairment, relaxants, antihypertensives, alcohol; respiratory
mouth, headache, vertigo; palpitations; or severe asthma; paralytic ileus; obstructive
hypothermia; pruritus, urticaria; tachycardia, airway disease; acute liver disease; comatose
bradycardia; blurred vision; miosis; dependency patients; pregnancy. acute alcoholism
morphine toxicity
Constipation, sedation, dry mouth,
Acute bronchial asthma, respiratory insufficiency, MAOIs: hypotension and exaggeration of CNS
Children less than 1 year, neonates, premature psychomimetic effect (dysphoria, hallucination,
severe CNS depression, GI obstruction, biliary and respiratory depressant effects. Naltrexone:
infants, elderly, chronic obstructive airway disease, nightmare), urinary retention, respiratory
Morphine Sulphate 10 mg Suppository Statex Relief of severe chronic pain (cancer patient) 15 - 30 mg regularly every 4 hours colic (these conditions are not contra-indications precipitation of opioid withdrawal symptoms.
pregnancy, lactation, renal and hepatic impairment, depression (clinically respiratory depression) is a
in patients who are terminally ill), hypersensitivity Cimetidine: morphine toxicity (CNS depression,
hypothyroidism rare occurrence in patients whose opioid doses
to morphine, MAOIs respiratory depression)
have been titrated
Constipation, nausea, vomiting, drowsiness, dry

mouth, psychomimetic effect (dysphoria, Acute bronchial asthma, respiratory insufficiency, MAOIs: hypotension and exaggeration of CNS
ADULT: 10 - 20 mg/kg or more SC or IM every 4 hours Children less then 1 year, neonates, premature
hallucination, nightmare), urinary retention, severe CNS depression, GI obstruction, biliary and respiratory depressant effects. Naltrexone:
For moderate to severe pain especially that associated in terminal pain. CHILD: Up to 1 month: 0.15 mg/kg infants, elderly, chronic obstructive airway disease,
Morphine Sulphate 10 mg/ml Injection - respiratory depression (rare). Convulsions; dry colic (these conditions are not contra-indications precipitation of opioid withdrawal symptoms.
with neoplastic disease body weight; 1 - 12 months: 0.2 mg/kg body weight; 1 - pregnancy, lactation, renal and hepatic impairment,
mouth, headache, vertigo; palpitations; in patients who are terminally ill), hypersensitivity Cimetidine : morphine toxicity (CNS depression,
5 years: 2.5 - 5 mg ; 6 - 12 years: 5 - 10 mg hypothyroidism
hypothermia; pruritus, urticaria; tachycardia, to morphine, MAOIs respiratory depression)
bradycardia; blurred vision; miosis; dependency
Children less than 1 year, neonates, premature psychomimetic effect (dysphoria, hallucination,
infants, elderly, chronic obstructive airway disease, nightmare), urinary retention, respiratory
have been titrated
morphine toxicity
Children less than 1 yr, neonates, premature infants, psychomimetic effect (dysphoria, hallucination,
elderly, chronic obstructive airway disease, nightmare), urinary retention, respiratory
have been titrated
mouth, psychomimetic effect (dysphoria, depression and biliary colic (these conditions are
hallucination, nightmare), urinary retention, not contra-indicated in patients who are
Morphine Sulphate 5 mg Immediate 5-10 mg every four hours. The dose may be increased chronic obstructive airway disease, pregnancy, phenothiazines, other tranquillizers, muscle
Statex Relief of moderate to severe pain (cancer patient) respiratory depression (rare). Convulsions; dry terminally ill). Hypersensitivity to morphine, acute
Release Tablet according to needs lactation, renal and hepatic impairment, relaxants, antihypertensives, alcohol; respiratory
mouth, headache, vertigo; palpitations; or severe asthma; paralytic ileus; obstructive
hypothermia; pruritus, urticaria; tachycardia, airway disease; acute liver disease; comatose
bradycardia; blurred vision; miosis; dependency patients; pregnancy. acute alcoholism
morphine toxicity
morphine toxicity
Warfarin, concomitant use with QT prolonging

Not to be injected subconjuctivally or introduced Conjunctivitis, decreased visual acuity, dry eye,
Moxifloxacin 0.5% Ophthalmic Treatment of conjunctivitis caused by susceptible CHILD more than 1 year and ADULT: 1 drop to affected agents (eg. Class 1a and class III antiarrythmic,
Vigamox directly to the anterior chamber of the eye, prolong keratitis, ocular discomfort, hyperemia, pain and Hypersensitivity to moxifloxacin and quinolone
Solution organism eye(s) 3 times daily for 7 days erythromycin, cisapride, antipsychotic, cyclic
use, pregnancy and lactation pruritus, subconjunctival hemorrhage, tearing
antidepressant), antacid, sucralfate
Pyridoxine will antagonise the therapeutic effect

of levodopa (should not be administered
INFANT less than 1 year: 1 ml daily or based on
Multivitamin Drops Abdec For prevention and treatment of vitamin deficiencies Severe renal or liver failure Hypervitaminosis Hypersensitivity to product components concurrently), vitamin B6 reduces the plasma
manufacturer
levels of phenobarbitone and phenytoin, ascorbic
acid increases plasma level of ethinyloestradiol

Initially 2 - 4 pairs IV 4 - 8 hourly, reducing to 1 pair IV of levodopa (should not be administered
Hypervitaminosis, high doses may induce
Multivitamin Injection Parentrovite For prevention and treatment of vitamin deficiencies daily. For less serious cases, 1 pair IV 1 - 2 times daily Severe renal or liver failure Hypersensitivity to product components concurrently), vitamin B6 reduces the plasma
paraesthesia and hypotension
or based on individual requirements levels of phenobarbitone and phenytoin, ascorbic

Multivitamin Syrup - For prevention and treatment of vitamin deficiencies CHILD 5 ml daily or based on manufacturer Severe renal or liver failure Hypervitaminosis Hypersensitivity to product components concurrently), vitamin B6 reduces the plasma
Multivitamin Tablet - For prevention and treatment of vitamin deficiencies 1 - 2 tablets daily or based on individual requirements Severe renal or liver failure Hypervitaminosis Hypersensitivity to product components Not known
Skin infection by Staphylococcus aureus (including Not for ophthalmic or intranasal use. Use with
Mupirocin 2% Cream Bactroban MRSA), Staphylococcus epidermidis and beta- 2 - 3 times a day caution if there is evidence of moderate or severe Stinging or burning, pruritus Hypersensitivity to mupirocin products Avoid products with polyethylene glycol
haemolytic streptococcus renal impairment
Not for ophthalmic or intranasal use. Use with
ADULT and CHILD: Apply up to three times daily for 3 -
Mupirocin 2% Ointment Bactroban For MRSA infections only caution if there is evidence of moderate or severe Stinging or burning, pruritus Hypersensitivity to mupirocin products Avoid products with polyethylene glycol
5 days
renal impairment
Fever, cerebrovascular disease, neurological
problems, concomitant drugs that affect the CNS,
underlying vascular disease and history of
thrombosis, increases the risk of infections and
certain malignancies. Caution when using intra-
uterine devices due to an increased risk of infection.
Hypersensitivity to muromonab, anti-mouse
Avoid use of live vaccines. Unstable angina, recent
Cytokine release syndrome, anaphylaxis, antibody titres more than or equal to 1:1000,
MI, ischaemic heart disease, heart failure, pulmonary
respiratory distress, haematopoietic effects, heart failure, fluid overload, pregnancy, lactation,
oedema, COPD, vascular overload or depletion,
Only for the treatment of severe acute rejection in neuro-psychiatric events, fever, chills, Patients with pre-existing fever or uncontrolled
ADULT & CHILD more than 30 kg: 5 mg daily for 10 - septic shock, cerebrovascular disease, advanced
kidney transplant patient. For severe acute graft-versus- gastrointestinal disturbances, myalgia, tremors, hypertension. Hypersensitivity to products of Azathioprine, corticosteroids, cyclosporin,
Muromonab-CD3 5 mg Injection Orthoclone OKT3 14 days. CHILD 30 kg and below: 2.5 mg daily for 10 - symptomatic vascular disease or neuropathy, low
host disease (GVHD) not responding to high dose dyspnoea, pulmonary oedema, seizures, murine origin. Avoid in patients with a history of indomethacin
14 days convulsion threshold, history of thrombotic events or
steroids encephalopathy, cerebral oedema and a seizures. Patients who have undergone a more
underlying vascular disease. Children with primary
syndrome resembling aseptic meningitis with than 3% weight gain in the week preceding
Epstein-Barr viral infection. Assess volume status
headache, stiff neck and photophobia therapy or who have radiographic evidence of
prior to therapy. Perform CXR 24 hour prior to
fluid overloading
therapy to exclude fluid overload or heart failure.
Perform baseline & periodic renal, hepatic &
haematopoietic tests. Monitor closely over 24 hour
following each of the 1st few doses. Child less than
or equal to 16 year. If hypersensitivity is suspected,
discontinue immediately & do not re-challenge
Full blood count weekly for 4 weeks, then twice a
month for 2 months, then monthly in the first year.
Elderly, active serious gastro-intestinal disease,
i) Renal transplant rejection: ADULT: 1 g twice daily. delayed graft function. Avoid exposure to sunlight.
Myelosuppression, hypertension, infection,
i) Prophylaxis of acute organ rejection in patients CHILD (3 months and older): 600 mg/m(2)/dose, twice Bone marrow suppression, monitor neutrophil count. Antacids, cholestyramine, decreased
diarrhoea, nausea and vomiting, constipation,
receiving allogenic renal, cardiac and hepatic daily; maximum daily dose, 2 g/10 mL. Cardiac If neutropenia develops, stop treatment or reduce mycophenolate mofetil efficacy. Iron decreased
Mycophenolate Mofetil 250 mg abdominal pain, dyspepsia, dizziness, insomnia, Hypersensitivity to mycophenolate mofetil and
Cellcept transplant ii) Used with steroids for induction and transplant rejection: 1.5 g twice daily. Hepatic transplant dose. Perform relevant diagnostic tests as mycophenolate mofetil efficacy. Azathioprine,
Capsule headache, tremor, leucopenia, anaemia, mycophenolic acid, pregnancy
maintenance of severe lupus nephritis resistant or rejection: 1.5 g twice daily ii) Induction phase: 2 - 3 necessary & complete blood counts weekly. Severe drugs which interfere with enterohepatic
thrombocytopenia, leucocytosis, polycythaemia,
intolerant to cyclophosphamide therapy g/day for up to 6 months. Maintenance phase: dose active digestive diseases, severe chronic renal recirculation, acyclovir, ganciclovir
electrolyte imbalances
gradually tapers to 1 g/day failure. Pregnancy & lactation. Increased risk for
opportunistic infections such as activation of latent
viral infections including BK virus -associated
nephropathy
Full blood count weekly for 4 weeks, then twice a
month for 2 months, then monthly in the first year.
Elderly, active serious gastro-intestinal disease,
i) Renal transplant rejection: ADULT: 1 g twice daily. delayed graft function. Avoid exposure to sunlight.
Myelosuppression, hypertension, infection,
i) Prophylaxis of acute organ rejection in patients CHILD (3 months and older): 600 mg/m(2)/dose, twice Bone marrow suppression. Monitor neutrophil count. Antacids, cholestyramine, decreased
diarrhoea, nausea / vomiting, constipation,
receiving allogenic renal, cardiac and hepatic daily; maximum daily dose, 2 g/10 mL. Cardiac If neutropenia develops, stop treatment or reduce mycophenolate mofetil efficacy. Iron decreased
abdominal pain, dyspepsia, dizziness, insomnia, Hypersensitivity to mycophenolate mofetil and
Mycophenolate Mofetil 500 mg tablet Cellcept transplant ii) Used with steroids for induction and transplant rejection: 1.5 g twice daily. Hepatic transplant dose. Perform relevant diagnostic tests as mycophenolate mofetil efficacy. Azathioprine,
headache, tremor, leucopenia, anaemia, mycophenolic acid, pregnancy
maintenance of severe lupus nephritis resistant or rejection: 1.5 g twice daily ii) Induction phase: 2 - 3 necessary & complete blood counts weekly. Severe drugs which interfere with enterohepatic
thrombocytopenia, leucocytosis, polycythaemia,
intolerant to cyclophosphamide therapy g/day for up to 6 months. Maintenance phase: dose active digestive diseases, severe chronic renal recirculation, aciclovir, ganciclovir
electrolyte imbalances
gradually tapers to 1 g/day failure. Pregnancy & lactation. Increased risk for
nephropathy
Avoid in patients with rare hereditary deficiency of
hypoxanthine-guanine hosphoribosyl-transferase
(HGPRT) (eg, Lesch-Nyhan and Kelley-Seegmiller
syndrome). Associated with an increased risk of
Leucopenia, neutropenia, lymphomas and skin
congenital malformations and spontaneous
malignancies. Increased risk of infections,
abortions when used during pregnancy. CellCept
constipation, insomnia, increased risk of first
and myfortic dosage forms should not be used
trimester pregnancy loss and increased risk of
interchangeably due to differences in absorption.
structural abnormalities in the infants born to Azathioprine, live vaccines, aciclovir, antacids
Increased risk of developing lymphomas & other Hypersensitivity, pregnancy, hypersensitivity to
Prophylaxis of acute transplant rejection in adult mothers receiving mycophenolate during with aluminium and magnesium hydroxides,
malignancies particularly of the skin. mycophenolate sodium, mycophenolic acid,
Mycophenolate Sodium 180mg Tablet Myfortic patients receiving allogenic renal transplant in 720 mg twice daily pregnancy. Diarrhoea, viral, bacterial & fungal cholestyramine and drugs that interfere with
Oversuppression of the immune system with mycophenolate mofetil or any other component
combination with ciclosporin and corticosteroids infections, anaemia, thrombocytopenia, enterohepatic circulation, ganciclovir, tacrolimus,
increased susceptibility to infection. Active serious of the product
headache, cough, abdominal distension, oral contraceptives and cyclosporin
digestive system disease. Bone marrow depression.
abdominal pain, abdominal tenderness,
Perform regular complete blood counts for
dyspepsia, flatulence, gastritis, loose stools,
monitoring neutropenia. Effective contraception must
nausea, vomiting, fatigue, pyrexia, abnormal
be used. Lactation. Severe chronic renal impairment.
hepatic function tests, increased blood creatinine
Avoid live attenuated vaccines. Increased risk for
nephropathy
Avoid in patients with rare hereditary deficiency of
hypoxanthine-guanine hosphoribosyl-transferase
(HGPRT) (eg, Lesch-Nyhan and Kelley-Seegmiller
syndrome). Associated with an increased risk of
Leucopenia, neutropenia, lymphomas and skin
congenital malformations and spontaneous
malignancies. Increased risk of infections,
abortions when used during pregnancy. CellCept
constipation, insomnia, increased risk of first
and myfortic dosage forms should not be used
trimester pregnancy loss and increased risk of
interchangeably due to differences in absorption.
structural abnormalities in the infants born to Azathioprine, live vaccines, aciclovir, antacids
Increased risk of developing lymphomas & other Hypersensitivity, pregnancy, hypersensitivity to
Prophylaxis of acute transplant rejection in adult mothers receiving mycophenolate during with aluminium and magnesium hydroxides,
malignancies particularly of the skin. mycophenolate sodium, mycophenolic acid,
Mycophenolate Sodium 360mg Tablet Myfortic patients receiving allogenic renal transplant in 720 mg twice daily pregnancy. Diarrhoea, viral, bacterial & fungal cholestyramine and drugs that interfere with
Oversuppression of the immune system with mycophenolate mofetil or any other component
combination with ciclosporin and corticosteroids infections, anaemia, thrombocytopenia, enterohepatic circulation, ganciclovir, tacrolimus,
increased susceptibility to infection. Active serious of the product
headache, cough, abdominal distension, oral contraceptives and cyclosporin
digestive system disease. Bone marrow depression.
abdominal pain, abdominal tenderness,
Perform regular complete blood counts for
dyspepsia, flatulence, gastritis, loose stools,
monitoring neutropenia. Effective contraception must
nausea, vomiting, fatigue, pyrexia, abnormal
be used. Lactation. Severe chronic renal impairment.
hepatic function tests, increased blood creatinine
Avoid live attenuated vaccines. Increased risk for
nephropathy
i) Prevention; moderate risk, 0.3 ml SC units daily for at
least 7 days or until the patient is ambulant; the first
dose being given 2 - 4 hours before the procedure.
High risk: 38 IU/kg pre & post -operation and daily
thereafter, up to third day post-operation. 57 IU/kg from
fourth day after surgery.Continue treatment for at least
Previous hypersensitivity to unfractionated heparin,
10 days. Above 70 kg: 0.4 ml pre-op & until day 3 & 0.6
patients with thrombocytopenia prior to therapy and
ml from day 4 onwards. 50 - 69 kg: 0.3 ml pre-op & until Hypersensitivity to nadroparin, cerebrovascular
i) Prevention of Deep Vein Thrombosis (DVT) recent childbirth. Peptic ulcer disease, renal Overt or concealed haemorrhage; rarely, severe
day 3 & 0.4 ml from day 4 onwards. Less than 50 kg: haemorrhage or other active haemorrhage
especially in perioperative and high risk surgical cases impairment (dose reductions if severe), liver disease thrombocytopenia, small haematoma, cutaneous NSAIDs, aspirin, oral anticoagulants, antiplatelet
Nadroparin Calcium 0.2 ml Injection Fraxiparine 0.2 ml pre-operative& until day 3, & 0.3 ml from day 4 (except disseminated intravascular coagulation).
ii) Treatment of DVT iii) Unstable angina & non-Q wave (alterations in haemostasis may affect response to necrosis at injection site; raised transaminases, agents, dextrans
onwards ii) Treatment: 2 daily injection 12 hourly. Cerebral aneurysm, severe and uncontrolled
myocardial infarction nadroparin). Recent lumbar puncture. Vasculitis, hypoaldosteronism
Above 100 kg: 1 ml/injection; 90 - 99 kg: 0.9 hypertension (risk of cerebral haemorrhage)
concurrent use of aspirin (increased bleeding risk).
ml/injection; 80 - 89 kg: 0.8 ml/injection; 70 - 79 kg: 0.7
Pericarditis or pericardial effusion
ml/injection; 40 - 49 kg: 0.4 ml/injection iii) Unstable
angina & non-Q wave myocardial infarct: 86 IU anti-
Xa/kg SC twice daily with aspirin (75-325 mg PO after
loading dose of 160- 325 mg) for 6 days until
stabilisation with dose adjusted to body weight
Perioperative analgesia, for relief of moderate to severe Impaired renal/hepatic function, MI, impaired Sedation, sweating, GI upsets, vertigo, dry
Nalbuphine HCl 10 mg/ml Injection Nubain 10 - 20 mg SC, IM or IV every 3 - 6 hours Hypersensitivity to nalbuphine Phenothiazines, alcohol, CNS depressants
pain respiration, biliary tract surgery mouth, allergic reactions
Opiate withdrawal symptoms, nausea, vomiting,
For the complete/partial reversal of narcotic depression Dependence may precipitate withdrawal symptoms, tachycardia, tremor, sweating, pulmonary
0.005 - 0.01 mg/kg body weight repeated at intervals of
including respiratory depression induced by opioids concurrent cardiotoxic drugs, pre-existing cardiac oedema, hyperventilation, cardiac dysrhythmia,
Naloxone HCl 0.02 mg/ml Injection Narcan 2 - 3 minutes according to the patient's needs by IM, IV Hypersensitivity to naloxone Clonidine: hypertension
such as natural and synthetic narcotics. Diagnosis of disease, narcotic dependency, pregnancy, lactation, biliary colic, dysphagia, memory impairment,
or SC
suspected acute opioids overdosage neonates seizure, agitation, dyspnea, laryngeal spasm,
pulmonary edema, tachyarrhythmia
Opiate withdrawal symptoms, nausea, vomiting,

For the complete/partial reversal of narcotic depression Dependence may precipitate withdrawal symptoms, tachycardia, tremor, sweating, pulmonary
including respiratory depression induced by opioids Initially 0.4 - 2 mg IV repeated at intervals of 2 - 3 concurrent cardiotoxic drugs, pre-existing cardiac oedema, hyperventilation, cardiac dysrhythmia,
Naloxone HCl 0.4 mg/ml Injection Narcan Hypersensitivity to naloxone Clonidine: hypertension
such as natural and synthetic narcotics. Diagnosis of minutes according to patient's needs disease, narcotic dependency, pregnancy, lactation, biliary colic, dysphagia, memory impairment,
suspected acute opioids overdosage neonates seizure, agitation, dyspnea, laryngeal spasm,
pulmonary edema, tachyarrhythmia
Should be discontinued at least 48 hours before

Initial 25 mg may be increased to 50 mg. Maintenance: Opioids analgesics: precipitation of opioid
elective surgery involving opioid analgesia. When Concomitant opioid analgesics, opioid
Adjunct in relapse prevention treatment in detoxified 350 mg weekly; administered as 50 mg daily. Dosing Opioid withdrawal-like syndrome, nausea, withdrawal symptoms. Disulfiram may increase
Naltrexone HCl 50 mg Tablet Trexan analgesia is required, larger doses than usual of dependency or withdrawal, hypersensitivity to
formerly opioid-dependant patients interval may be lengthened to improve compliance; 100 headache, dizziness, anxiety risk of hepatotoxicity. Thioridazine may cause
opioids will be needed and there is an increased risk naltrexone, acute hepatitis or liver failure
mg on alternate days or 150 mg every third day lethargy and somnolence
of respiratory depression and other adverse effects
Congestive heart failure or hypertension.Patients

with coronary artery disease, previous myocardial Hypersensitivity to nandrolone products, male
infarction, or lipid-lipoprotein abnormalities, hepatic breast/prostate cancer, metastatic female breast Increased toxicity: Oral anticoagulants, insulin,
Nandrolone Decanoate 25 mg/ml ADULT: 25 - 50 mg every 3 weeks by IM. CHILD over 2 Acne, amenorrhoea, oedema, hypertension,
Deca-Durabolin Anabolic therapy or renal function impairment, diabetes mellitus, cancer with hypercalcaemia, nephrosis/nephrotic oral hypoglycaemic agents, adrenal steroids,
Injection years: 25 - 50 mg every 3 to 4 weeks virilization, hypoglycaemia, lipid abnormalities
benign prostatic hypertrophy, breast-feeding period, phase of nephritis, known/suspected pregnancy, ACTH
lupus erythematosus, previous hypersensitivity to severe liver disease
other androgens or anabolic steroids
Active or previous history of gastrointestinal
Abdominal discomfort, epigastric distress,
ulceration, bleeding or perforation. History of renal or Hypersensitivity, active or history of peptic
gastrointestinal reactions, peptic ulceration, skin Probenecid, oral anticoagulants, thiazide
liver dysfunction or coagulation defects. ulceration. Patients whom aspirin & other
Naproxen 25 mg/ml Suspension Naprosyn Juvenile arthritis CHILD: over 5 years: 10 mg/kg daily in 2 divided doses rash, pruritus, insomnia, visual disturbance, diuretics, ACEIs, beta-blockers, methotrexate,
Hypertension or cardiac conditions aggravated by NSAIDs induced symptoms of asthma, rhinitis,
headache, nausea, peripheral oedema, tinnitus, lithium, aspirin, other NSAIDs
fluid retention and oedema, dehydration, diuretics, urticaria or other allergic reactions
vertigo. Prolongs bleeding time
pregnancy and lactation
i) Rheumatic arthritis, osteoarthritis and ankylosing i) 0.5 - 1 g daily in 2 divided doses ii) 750 mg initially gastrointestinal reactions, peptic ulceration, skin Probenecid, oral anticoagulants, thiazide
Naproxen 250 mg Tablet Naprosyn spondylitis ii) Acute gout iii) Muscular skeletal disorder, then 250 mg 8 hourly iii) 500 mg initially then 250 mg rash, pruritus, insomnia, visual disturbance, diuretics, ACEIs, beta-blockers, methotrexate,
dysmenorrhoea every 6 - 8 hour as required headache, nausea, peripheral oedema, tinnitus, lithium, aspirin, other NSAIDs
i) Rheumatic arthritis, osteoarthritis and alkylosing i) 0.5 - 1 g daily in 2 divided doses ii) 750 mg initially gastrointestinal reactions, peptic ulceration, skin Probenecid, oral anticoagulants, thiazide
Naproxen Sodium 275 mg Tablet - spondylitis ii) Acute gout iii) Muscular skeletal disorder then 250 mg 8 hourly iii) 500 mg initially then 250 mg rash, pruritus, insomnia, visual disturbance, diuretics, ACEIs, beta-blockers, methotrexate,
and dysmenorrhoea every 6 - 8 hours as required headache, nausea, peripheral oedema, tinnitus, lithium, aspirin, other NSAIDs
Skin sensitization or contact dermatitis. The
Apply sparingly to affected area up to 3 times daily (For Superinfection may occur on prolonged use. Renal Hypersensitivity to neomycin or other
Neomycin 0.5% Cream - Infections of the skin due to susceptible organisms sensitivity disappears when treatment is Not known
short term use, 1 - 2 weeks) impairment aminoglycosides
discontinued
Treatment of the following conditions where bacterial
Neomycin 0.5% in Betamethasone 17- infection is present or likely to occur: eczemas, prurigo Apply sparingly to affected area 2 - 3 times daily. (May Superinfection may occur on prolonged use. Renal
Betnovate-N sensitivity disappears when treatment is Hypersensitivity to any of its component Not known
Valerate 0.01% Cream nodularis, psoriasis (excluding widespread plaque cause sensitisation to neomycin. Use with caution) impairment
discontinued
psoriasis), neurodermatoses, anal and genital intertrigo

Neomycin 0.5% in Betamethasone 17- infection is present or likely to occur: eczemas, prurigo Apply sparingly to affected area 2 to 3 times daily. (May Superinfection may occur on prolonged use. Renal
Valerate 0.01% Ointment nodularis, psoriasis (excluding widespread plaque cause sensitisation to Neomycin. Use with caution) impairment
discontinued

Neomycin 0.5% in Betamethasone 17- infection is present or likely to occur: eczemas, prurigo Apply sparingly to affected area 2 - 3 times daily (May Superinfection may occur on prolonged use. Renal
Valerate 0.1% Cream nodularis, psoriasis (excluding widespread plaque cause sensitisation to neomycin. Use with caution) impairment
discontinued

Neomycin 0.5% in Betamethasone 17- infection is present or likely to occur: eczemas, prurigo Apply sparingly to affected area 2 to 3 times daily. (May Superinfection may occur on prolonged use. Renal
Valerate 0.1% Ointment nodularis, psoriasis (excluding widespread plaque cause sensitisation to neomycin. Use with caution) impairment
discontinued
Apply sparingly to affected area up to 3 times daily (For Superinfection may occur on prolonged use, renal Hypersensitivity to neomycin or other
Neomycin 0.5% Ointment - Infections of the skin due to susceptible organisms sensitivity disappears when treatment is Not known
short term use, 1- 2 weeks) impairment aminoglycosides
discontinued
The preparation may also be associated with
localized hypersensitivity (due to neomycin
content). Symptoms consist of ocular itching,
reddening, conjunctival oedema, rash, or
persistent irritation, and may be mistakenly
Cross-sensitivity may occur with kanamycin,
confused as a worsening of the condition being
Neomycin with Polymyxin B Sulphate 1 - 2 drops in the affected eye 2 - 4 times daily. In streptomycin, tobramycin, and gentamicin. Hypersensitivity to any of the components or to
Neosporin Eye infections that require a broad spectrum antibiotic treated. Sensitization to neomycin is more likely Not known
and Gramicidin Eye Drops severe infections : 1 - 2 drops every 15 - 30 minutes Prolonged use may enable overgrowth of non- other aminoglycosides
when the drug is given topically for longer than 5
susceptible organisms, including fungi
or 6 days. These reactions are reversible. The
product should be discontinued if signs of
sensitization occur, and such patients should
avoid neomycin-containing products in the
future. Bilateral periorbital oedema has been
reported
i) ADULT: 1 - 2.5 mg at suitable intervals by SC, IM or Allergic reactions, salivation, gastrointestinal Antagonism effect by lithium, antimuscarinics,
IV. Usual total daily dose 5 - 20 mg. CHILD: 200 - 500 upsets, diaphoresis, diarrhea, flatulence, aminoglycoside, clindamycin, procainamide,
Bronchial asthma (extreme caution), bronchitis,
Neostigmine Methylsulphate 2.5 i) Myasthenia gravis ii) Reversal of non-depolarising mcg at suitable intervals throughout the day. increased peristalsis, nausea and vomiting, Mechanical intestinal or urinary obstruction, quinidine, propranolol. Enhanced effect of
Prostigmine bradycardia, peptic ulcer, epilepsy, parkinsonism,
mg/ml Injection neuromuscular blockade NEONATE: 50 - 250 mcg every 4 hours ii) By IV cardiac dysrhythmia, anaphylaxis, seizure, peritonitis suxamethonium. Chloroquine have potential to
injection over 1 minute, 50 - 70 mcg/kg (maximum 5 bronchospasm, respiratory arrest, respiratory increase symptoms of myasthenia gravis.
mg) after or with atropine sulphate 0.6 - 1.2 mg depression Cyclopropane or halothane
ADULT: 4 - 6.5 mg/kg/day IM or IV in 2 - 3 equally
Renal impairment; neuromuscular disorder eg
divided doses for 7 - 14 days. Maximum: 7.5 Nephrotoxicity, neurotoxicity (auditory & Lysine, tacrolimus, neuromuscular blockers such
Netilmicin Sulphate 100 mg/2 ml myasthenia gravis or Parkinson, hypocalcaemia. Known allergy to netilmicin
Netromycin Systemic infections mg/kg/day. CHILD: 5 - 7.5 mg/kg/day 8 - 12 hourly vestibular toxicity); local reactions; GI effects, as alcuronium, pancuronium, rocuronium,
Injection Pregnancy & lactation. Good hydration during products/aminoglycosides
depending on gestation and age. Maximum: 7.5 fever; blood coagulation abnormalities vecuronium
treatment required
mg/kg/day
treatment required
mg/kg/day
treatment required
mg/kg/day
Hepatic impairment, history of chronic hepatitis,
Hepatitis, hepatic failure (life threatening), Hypersensitivity to nevirapine or any component Methadone, rifampicin, ketoconazole, other
Treatment of HIV-1 infection in combination with other 200 mg once daily for first 14 days then 200 mg twice hepatic disease, pregnancy. Avoid use in patients
Nevirapine 200 mg Tablet hepatotoxicity, severe skin reaction, headache, of the formulation, breast feeding, severe hepatic antivirals such as saquinaxir, indinavir, St. John's
antiretroviral agents daily with CD4 cell counts more than 250 cells/mm3 in
fatique, diarrhoea, nausea, rash impairment wort, warfarin
adult women and 400 cells/mm3 in adult men
Renal disease, history of liver disease, consumption Flushing with burning of the hands, ears and
of substantial quantities of alcohol, unstable angina, face, pruritis and rash, gastrointestinal upset,
Prophylactic: 15 - 30 mg daily. Therapeutic: 50 - 250 Active liver disease, active peptic ulcer disease, Aspirin, atorvastatin, colestipol, cholestyramine,
concurrent vasoconstrictors and concurrent hypotension, diarrhoea, nausea, vomiting,
Nicotinic Acid 50 mg Tablet Niacin For prophylaxis and treatment of Vitamin B3 deficiency mg daily. Maximum single dose: 200 mg. Maximum hypersensitivity to niacin or any of its fluvastatin, isoniazid, lovastatin, nicotine,
anticoagulants. Predisposition to gout. Women have abdominal pain, feeling of restlessness,
dose in 24 hours: 800 mg components simvastatin, ethanol and pravastatin
a greater hypolipidaemic response than men at headache, hypotension, rash, tingling, itching
equivalent doses. Pregnancy and lactation and dry skin
100 - 200 mg 3 times daily, gradually increased over 2 - Renal disease, history of liver disease, consumption Flushing with burning of the hands, ears and
4 weeks to 1 - 2 g 3 times daily with or after meals. of substantial quantities of alcohol, unstable angina, face, pruritis and rash, gastrointestinal upset,
Active liver disease, active peptic ulcer disease, Aspirin, atorvastatin, colestipol, cholestyramine,
CHILD: 100 - 250 mg/day in 3 divided doses with concurrent vasoconstrictors and concurrent hypotension, diarrhoea, nausea, vomiting,
Nicotinic Acid 500 mg Tablet Niacin Hyperlipidaemia hypersensitivity to niacin or any of its fluvastatin, isoniazid, lovastatin, nicotine,
meals, increase 100 mg/day weekly or 250 mg/day anticoagulants. Predisposition to gout. Women have abdominal pain, feeling of restlessness,
components simvastatin, ethanol and pravastatin
every 2 - 3 weeks as tolerated. Maximum: 10 a greater hypolipidaemic response than men at headache, hypotension, rash, tingling, itching
mg/kg/day equivalent doses. Pregnancy and lactation and dry skin
Angina (exacerbation) during initiation of treatment,

with dosage increases, during beta-blocker
withdrawal, taper slowly prior to calcium channel
blocker therapy. Chronic renal insufficiency,
combination therapy with beta-blockers (with left
ventricular dysfunction), congestive heart failure,
Beta-adrenergic blockers, cimetidine, digoxin,
gastrointestinal hypermotility (extended release dose
Hypersensitivity to nifedipine, symptomatic diltiazem, fluconazole, itraconazole,
10 - 30 mg 3 times daily. Maximum: 120 - 180 mg per forms) and obstruction (extended release dose Peripheral oedema, headache, dizziness,
Nifedipine 10 mg Capsule Adalat Hypertension hypotension, persistent dermatologic reactions, ketoconazole, magnesium, oral anticoagulants,
day forms). Hypotension (with initial therapy, combination tachycardia
chronic heart failure phenytoin, quinidine, rifampin, saquinavir,
beta-blocker therapy), liver function, isolated
vincristine
transaminase elevation usually mild and transient,
hepatocellular injury may occur, peripheral oedema
(confounding physical findings in congestive failure),
persistent dermatologic reactions induced by
calcium antagonists have progressed to erythema
multiforme or exfoliative dermatitis
Angina (exacerbation) during initiation of treatment,
Beta-adrenergic blockers, cimetidine, digoxin,
with dosage increases during beta-blocker
Hypersensitivity to nifedipine, symptomatic diltiazem, fluconazole, itraconazole,
Initial dose of 10 mg twice daily. Usual range 10 - 30 withdrawal, taper slowly prior to calcium channel Peripheral oedema, headache, dizziness,
Nifedipine 10 mg Tablet Adalat Hypertension hypotension, persistent dermatologic reactions, ketoconazole, magnesium, oral anticoagulants,
mg 3 times daily. Maximum: 120 - 180 mg per day blocker therapy. Chronic renal insufficiency, tachycardia
chronic heart failure phenytoin, quinidine, rifampin, saquinavir,
combination therapy with beta-blockers (with left
vincristine
ventricular dsfunction)
Peripheral oedema, dry skin, pruritus, rash,
hyperglycemia (grades 3 or 4), CYP3A4 inhibitors including ketoconazole,
hypophosphatemia (grades 3 or 4), constipation, itraconazole, voriconazole, ritonavir,
Myelosuppression. Patients with hypokalaemia,
Treatment of chronic phase and accelerated phase diarrhoea, increased serum lipase level (grade 3 clarithromycin, telithromycin, CYP3A4 inducers
hypomagnesaemia, under antiarrhythmic
Philadelphia chromosome positive chronic or 4), nausea, vomiting, arthralgia, bone pain, such as phenytoin, rifampicin, carbamazepine,
medications and anthracycline therapy may develop
myelogenous leukaemia (CML) in adults who: i) Failed myalgia, pain in limb, muscle spasm, asthenia, phenobarbitone, St. John's wort, antacids, H2-
400 mg twice daily, 12 hours apart. No food should be QT prolongation. Hepatic impairment. History of Lactation. Hypokalemia, hypomagnesemia, long
Nilotinib 200 mg Capsule Tasigna® imatinib ie no cytogenic response and no headache, fatigue, cough, dyspnoea, blockers, proton pump inhibitors, midazolam,
taken two hours before and 1 hour after taking the dose pancreatitis. Galactose intolerance, severe lactase QT syndrome
haematological response by 12 months ii) Have nasopharyngitis, fever, sudden death, prolonged astemizole, quinidine, bepridil, ergot alkaloids,
deficiency or glucose-galactose malabsorption.
molecular resistance to Imatinib as shown by molecular QT interval, intracranial hemorrhage, pneumonia, warfarin, amiodarone, disopyramide,
Pregnancy. May impair ability to drive or operate
mutation studies iii) Are intolerant to Imatinib hypokalemia, hyponatremia, anemia, febrile procainamide, sotalol, chloroquine, haloperidol,
machines
neutropenia, neutropenia, thrombocytopenia, methadone, grapefruit juice, moxifloxacin,
ALT (SGPT) level raised, AST/SGOT level clozapine, digoxin
raised, hyperbilirubinemia
Potentiates effects of antihypertensives. IV beta-
blockers (avoid). Possible increase of nimodipine
IV infusion of 1 mg/hour for a period of 2 hours (about Severe blood pressure lowering. Gastrointestinal
Prophylaxis & treatment of ischaemic neurological Generalised cerebral oedema or raised intracranial blood concentration with cimetidine. Possible
Nimodipine 10 mg/50 ml Infusion 15 mcg/kg/hour). IV therapy should be started no later disturbances. In addition for infusion: Hypersensitivity to nimodipine, within 1 month of
Nimotop deficits caused by cerebral vasospasm following pressure, hypotension. Pregnancy. Monitor renal decrease of nimodipine efficacy with rifampicin.
Solution than 4 days after haemorrhage & continue for up to 10 - deterioration of renal function, disturbances of myocardial infarction, unstable angina
subarachnoid haemorrhage of aneurysmal origin function when used with nephrotoxic drugs Nephrotoxic drugs, monitor renal function,
14 days heart rhythm, phlebitis, increase of liver enzymes
zidovudine, cimetidine, antiepileptics, rifampicin,
grapefruit juice
Potentiates effects of antihypertensives. IV beta-
blockers (avoid). Possible increase of nimodipine
Severe blood pressure lowering. Gastrointestinal
Prophylaxis & treatment of ischaemic neurological Generalised cerebral oedema or raised intracranial blood concentration with cimetidine. Possible
disturbances. In addition for infusion: Hypersensitivity to nimodipine within 1 month of
Nimodipine 30 mg Tablet Nimotop deficits caused by cerebral vasospasm following 360 mg daily in divided doses for 7 days pressure, hypotension. Pregnancy. Monitor renal decrease of nimodipine efficacy with rifampicin.
deterioration of renal function, disturbances of myocardial infarction, unstable angina
subarachnoid haemorrhage of aneurysmal origin function when used with nephrotoxic drugs Nephrotoxic drugs, monitor renal function,
heart rhythm, phlebitis, increase of liver enzymes
zidovudine, cimetidine, antiepileptics, rifampicin,
grapefruit juice
Elderly patients (increased sensitivity to central Hypersensitivity to nitrazepam products or
5 - 10 mg at bedtime. ELDERLY or debilitated 2.5 - 5 nervous system effects), pregnancy, breast feeding, benzodiazepines, respiratory depression, acute
Confusion, dependence, dizziness, drowsiness, Enhances sedative effect of centrally acting
Nitrazepam 5 mg Tablet Mogadon Epilepsy (infantile spasms) mg. CHILD not recommended. Increasing slowly respiratory disease, muscle weakness, hepatic and pulmonary insufficiency, severe hepatic
amnesia drugs
according to response renal impairment, avoid prolong use and abrupt impairment, myasthenia gravis, sleep apnoea
withdrawal, reduce dose in elderly and debilitated syndrome
i) Acute uncomplicated infections: ADULT: 50 mg every
6 hours or 100 mg every 12 hours with food for 7 days.
Anorexia, nausea, vomiting, diarhoea, acute and
CHILD more than 3 months: 3mg/kg/day in 4 divided Pulmonary disorders or hepatic impairment, Impaired renal function, infants less than 3 Concurrent use with norfloxacin may result in
chronic pulmonary reactions, peripheral
doses ii) Severe chronic recurrent infection: ADULT: neurological or allergic disorders, anaemia, diabetes months old, glucose-6-phosphate deficiency antagonism of antibacterial effect of norfloxacin.
Nitrofurantoin 100 mg Tablet Furadantin Uncomplicated lower urinary tract infections neuropathy, hypersensitivity reactions, hepatic
100 mg every 6 hours with food for 7 days (dose mellitus, elderly and debilitated, monitor lung and (G6PD) including breast-feeding of affected Fluconazole may increased risk of hepatic or
reaction (hepatic necrosis, hepatic failure,
reduced or discontinued if severe nausea) iii) liver function on long-term therapy infants, pregnancy at term and porphyria pulmonary toxicity. Probenecid, antacids
hepatitis, jaundice)
Prophylaxis: 50 - 100 mg at night. CHILD over 3
months: 1 mg/kg at night
Peripheral vascular thrombosis, concomitant Gangrene, cyanosis peripheral. Occasionally,
Noradrenaline Acid Tartrate cyclopropane and halothane anaesthesia, profound bradycardia, anxiety, transient headache,
Septic shock and shock where peripheral vascular Infuse and titrate to desired pressure response. Range:
(Norepinephrine Bitartrate) 4 mg/4 ml Levophed hypoxia. Coadministration with MOAIs or tricyclic plasma volume depletion (prolonged Blood volume deficit MAOIs, tricyclic antidepressants
resistance is low 0.05 - 0.5 mcg/kg/minute
Injection antidepressants. Sulfite allergy (seen more administration), respiratory difficulty, ischaemic
frequently in asthmatic than nonasthmatic patients) injury
Gastrointestinal distress, oedema, menstrual Hypersensitivity, breast carcinoma, liver disease

Gastrointestinal disease (impaired absorption of oral disorders, dermatologic effects, nausea, fatique, or dysfunction, pregnancy, incomplete abortion,
Effectiveness may be reduced by antibiotics,
1 tablet daily starting on the first day of the menstrual contraceptive steroids in the small bowel due to depression, acne, hirsutism, breast tenderness, abnormal and undiagnosed vaginal bleeding,
Norethisterone 0.35 mg Tablet Noriday Contraception phenytoin, carbamazepine, barbiturates,
bleeding inflammatory disease, diarrhoea, ileostomy or thromboembolic phenomena, galactorrhoea, active or history of thromboembolic disease,
rifampicin
jejunoileal bypass may result in contraceptive failure) decreased glucose tolerance, anaphylaxis, thrombophlebitis, hypercoagulable state.
corticoid like reaction (high doses) Cerebral vascular or coronary artery diseases
Benign and rarely malignant liver tumours which
may lead to life threatening intra abdominal
Pregnancy, thromboembolic diseases,
haemorrhage have been observed. If severe upper
hypertension, acute and severe chronic liver
By deep IM injection only. First injection is within first 5 abdominal complaints, liver enlargement or signs of
Nausea, headache, dizziness, depressive disease, existing or treated breast or uterine Action may be impaired by barbiturates,
Norethisterone Enanthate 200 mg/ml days of the cycle. The next 3 injections are given at 8 intra abdominal haemorrhage occur, a liver tumour
Noristerat Contraception moods, spotting, breakthrough bleeding, cancers, severe diabetes with vascular changes, phenylbutazone, hydantoins, rifampicin and
Injection weeks interval after which the injection interval should should be considered. Porphyria, diabetes, smoking,
amenorrhoea, rarely weight gain history of or existing liver tumours, disturbances ampicillin
be extended to 12 weeks age, sickle cell anaemia, history of phlebitis or
of lipid metabolism, history of extrauterine
thromboembolic diseases, impaired liver function,
pregnancy if one tube is missing
history of extrauterine pregnancy if one tube is
missing
ADULT and CHILD more than 1 year : 1-2 drops 4 Local burning or smarting. Rarely, conjunctival Hypersensitivity to norfloxacin or other
Superficial infections of the eye (Pseudomonas Pregnancy, lactation, children less than 1 year,
Norfloxacin 0.3% Eye Drops Chibroxin times daily. First day : 1 - 2 drops two hourly during hyperemia, chemosis, photophobia and a bitter quinolones. History of tendinitis or tendon rupture Not known
aeruginosa and MRSA) and its adnexae impaired renal function, CNS disorders
waking hours (depending on severity) taste following instillation associated with norfloxacin or other quinolones
Apply liberally to affected area twice daily or as
required. After lesion has disappeared continue
Prevention and treatment of cutaneous infections
Nystatin 100,000 units/g Cream Mycostatin treatment for 10 days to prevent relapses. Nail Pregnancy Skin irritation Hypersensitivity to nystatin Not known
caused by Candida albicans
infection: Cut nails as short as possible. Apply cream
once daily until growth of new nail has set in
Apply liberally to affected area twice daily or as
required. After lesion has disappeared continue
Prevention and treatment of cutaneous or
Nystatin 100,000 units/g Ointment Mycostatin treatment for 10 days to prevent relapses. Nail Pregnancy Skin irritation Hypersensitivity to nystatin Not known
mucocutaneous infections caused by Candida albicans
infection: Cut nails as short as possible. Apply cream
once daily until growth of new nail has set in
Prevention and treatment of candidiasis of the skin and NEWBORN: 50,000-100,000 units daily. CHILD up to 5
mucous membranes, protection against candidas years: 100,000 -500,000 units 6 hourly. CHILD up to 6- Not intended to treat systemic mycoses. If GI disturbances, rash, urticaria , Steven Johnson
Nystatin 100,000 units/ml Suspension Mycostatin Hypersensitivity to nystatin Not known
overgrowth during antimicrobial /corticosteroid therapy 12 years and ADULT: 500,000-1,000,000 units 3 to 4 hypersensitivity develops, discontinue use Syndrome, oral irritation
and as selective decontamination regimens times daily
Prevention and treatment of candidiasis of the skin and

ADULT: 500,000 -1,000,000 units 6 hourly, according
mucous membranes, protection against candidas Not intended to treat systemic mycoses. If GI disturbances, rash, urticaria, Steven Johnson
Nystatin 500,000 units Tablet Mycostatin to severity of infections. CHILD: 100,000-500,000 units Hypersensitivity to nystatin Not known
overgrowth during antimicrobial /corticosteroid therapy hypersensitivity develops, discontinue use Syndrome, oral irritation
6 hourly
and as selective decontamination regimens
Local reaction and discomfort at injection site.

i) Acromegaly ii) Treatment of patients with symptoms Anorexia, nausea, vomiting, crampy abdominal
associated with gastro-entero-pancreatic endocrine pain, abdominal bloating, flatulence, loose stools,
tumours iii) Carcinoid tumours with features of the i, ii and iii) Initially 0.005 - 0.1 mg SC 1 - 2 times daily, diarrhoea, steatorrhea, rarely progressive
Growth hormone secreting pituitary tumours (can
carcinoid syndrome, VIPomas, glucagonomas, increase gradually up to 0.1 - 0.2 mg 3 times daily iv) abdominal distension, severe epigastric pain,
expand and cause space occupying effects), Reduces absorption of cyclosporin, cimetidine.
Octreotide 0.05 mg/ml Injection Sandostatin gastrinomas/Zollinger-Ellison syndrome, GRFomas, 0.1 mg 3 times daily for 7 consecutive days, starting on abdominal tenderness, guarding, acute Hypersensitivity to octreotide
insulinomas (exaggerate hypoglycaemia), diabetes, Increases bioavailability of bromocriptine
insulinomas iv) Prevention of complications following the day of operation, at least 1 hour before laparotomy pancreatitis. Impairment of post-prandial glucose
pancreatic surgery v) Emergency management of v) 25 mcg/hour for 5 days by continous IV infusion tolerance, hyperglycaemia, hypoglycemia,
bleeding gastro-eosophageal varices in patients with isolated case of hepatic dysfunction,
cirrhosis bradycardia, anaphylactic reactions. Long-term
treatment: gallstones
Local reaction and discomfort at injection site.
i) Acromegaly ii) Treatment of patients with symptoms Anorexia, nausea, vomiting, crampy abdominal
associated with gastro-entero-pancreatic endocrine pain, abdominal bloating, flatulence, loose stools,
tumours iii) Carcinoid tumours with features of the i, ii and iii) Initially 0.005 - 0.1 mg SC 1 - 2 times daily, diarrhoea, steatorrhea, rarely progressive
Growth hormone secreting pituitary tumours (can
carcinoid syndrome, VIPomas, glucagonomas, increase gradually up to 0.1 - 0.2 mg 3 times daily iv) abdominal distension, severe epigastric pain,
expand and cause space occupying effects), Reduces absorption of cyclosporin, cimetidine.
Octreotide 0.1 mg/ml Injection Sandostatin gastrinomas/Zollinger-Ellison syndrome, GRFomas, 0.1 mg 3 times daily for 7 consecutive days, starting on abdominal tenderness, guarding, acute Hypersensitivity to octreotide
insulinomas (exaggerate hypoglycaemia), diabetes, Increases bioavailability of bromocriptine
insulinomas iv) Prevention of complications following the day of operation, at least 1 hour before laparotomy pancreatitis. Impairment of post-prandial glucose
pancreatic surgery v) Emergency management of v) 25 mcg/hour for 5 days by continous IV infusion tolerance, hyperglycaemia, hypoglycemia,
bleeding gastro-eosophageal varices in patients with isolated case of hepatic dysfunction,
cirrhosis bradycardia, anaphylactic reactions. Long-term
treatment: gallstones
i) Adjunctive treatment for active acromegaly Local reaction and discomfort at injection site.
(second/third line therapy in whom surgery or Anorexia, nausea, vomiting, crampy abdominal
radiotherapy is inappropriate or ineffective- based on pain, abdominal bloating, flatulence, loose stools,
level of growth hormone and high IGF-1 and residual diarrhoea, steatorrhoea, rarely progressive
pituitary tumor). ii) Treatment of symptoms associated abdominal distension, severe epigastric pain,
Insulinomas, diabetes, pregnancy, lactation, Reduces absorption of cyclosporin, cimetidine.
Octreotide Acetate 20 mg Injection Sandostatin LAR with functional gastro-entero-pancreatic endocrine 10 - 30 mg every 4 weeks as deep intragluteal injection abdominal tenderness, guarding, acute Hypersensitivity to octreotide
cardiovascular disease, renal impairment Increases bioavailability of bromocriptine
tumours. iii) Carcinoid tumours with features of the pancreatitis. Impairment of post-prandial glucose
carcinoid syndrome, VIPomas, Glucagonomas, tolerance, hyperglycaemia, hypoglycaemia.
Gastrinomas/Zollinger-Ellison syndrome, Insulinomas, Isolated case of hepatic dysfunction,
for pre-operative control of hypoglycemia and for bradycardia, anaphylactic reactions. Long-term
maintenance therapy, GRFomas. treatment: gallstones
i) Adjunctive treatment for active acromegaly Local reaction and discomfort at injection site.
(second/third line therapy in whom surgery or Anorexia, nausea, vomiting, crampy abdominal
radiotherapy is inappropriate or ineffective- based on pain, abdominal bloating, flatulence, loose stools,
level of growth hormone and high IGF-1 and residual diarrhoea, steatorrhoea, rarely progressive
pituitary tumor). ii) Treatment of symptoms associated abdominal distension, severe epigastric pain,
Insulinomas, diabetes, pregnancy, lactation, Reduces absorption of cyclosporin, cimetidine.
Octreotide Acetate 30 mg Injection Sandostatin LAR with functional gastro-entero-pancreatic endocrine 10 - 30 mg every 4 weeks as deep intragluteal injection abdominal tenderness, guarding, acute Hypersensitivity to octreotide
cardiovascular disease, renal impairment Increases bioavailability of bromocriptine
tumours. iii) Carcinoid tumours with features of the pancreatitis. Impairment of post-prandial glucose
carcinoid syndrome, VIPomas, Glucagonomas, tolerance, hyperglycaemia, hypoglycaemia.
Gastrinomas/Zollinger-Ellison syndrome, Insulinomas, Isolated case of hepatic dysfunction,
for pre-operative control of hypoglycemia and for bradycardia, anaphylactic reactions. Long-term
maintenance therapy, GRFomas. treatment: gallstones
If otic therapy does not resolve otorrhea after a full
Acute otitis media with tympanostomy tubes, chronic CHILD: 1 - 12 years: 5 drops twice daily for 10 days. Antacids, sucralfate, oral antidiabetics, warfarin,
course of therapy, further evaluation is suggested for Ear ache, secondary fungal infection, otalgia,
Ofloxacin 0.3% Otic Solution Tarivid suppurative otitis media with perforated tympanic ADULT and CHILD over 12 years: 6 - 10 drops twice Hypersensitiviti to ofloxacin, pregnancy, lactation theophylline, probenecid, aminoglycosides, beta-
other underlying causes. Prolonged use may result hearing reduction
membranes and otitis externa daily and remain in the ear about 10 minutes lactam antibiotics
in overgrowth of fungal
Rash, GI discomfort, insomnia, dizziness, rash,

CNS disorders or other risk factors that may
i) As second-line treatment of leprosy ii) As second-line pruritus, headache, photosensitivity, diarrhoea,
predispose to seizures or lower the seizure Antacids, sucralfate, oral antidiabetics, warfarin,
treatment for tuberculosis and multidrug resistant i) 400 mg/day ii) 400 mg twice daily iii) 200 mg twice nausea, vomiting, cardiac dysrhythmia, QT Hypersensitivity to quinolones. Pregnancy,
Ofloxacin 100 mg Tablet Tarivid threshold. Renal or hepatic impairment, diabetes. theophylline, probenecid, aminoglycosides, beta-
tuberculosis (MDR-TB) iii) Sequential therapy for UTI daily prolongation, immune hypersensitivity reaction, lactation
Avoid exposure to direct sunlight. Children less than lactam antibiotics
and pyelonephritis traumatic or non-traumatic rupture of tendon,
18 years
peripheral neuropathy, seizure
Rash, GI discomfort, insomnia, dizziness, rash,

CNS disorders or other risk factors that may
pruritus, headache, photosensitivity, diarrhoea,
200 mg IV twice daily for 3 - 5 days followed with 200 predispose to seizures or lower the seizure Antacids, sucralfate, oral antidiabetics, warfarin,
nausea, vomiting, cardiac dysrhythmia, QT Hypersensitivity to quinolones. Pregnancy,
Ofloxacin 200 mg Injection Rifocin Sequential therapy for UTI and pyelonephritis mg tablet twice daily for 3 - 5 days as maintenance threshold. Renal or hepatic impairment, diabetes. theophylline, probenecid, aminoglycosides, beta-
prolongation, immune hypersensitivity reaction, lactation
dose (if necessary) Avoid exposure to direct sunlight. Children less than lactam antibiotics
traumatic or non-traumatic rupture of tendon,
18 years
peripheral neuropathy, seizure
History of neuroleptic malignant syndrome, patients
with liver disease, seizure disorder, pneumonia,
narrow angle glaucoma, pregnancy, cardiovascular
disease, history of breast cancer, tardive dyskinesia,
gastrointestinal obstruction, paralytic ileus, Somnolence, agitation, dizziness, constipation, Carbamazepine, ciprofloxacin, fluvoxamine,
i) 5 - 10 mg once daily, increase to 10 mg once daily
cerebrovascular disease, elderly, hypotension, drowsiness, weight gain, peripheral oedema, dry levodopa, haloperidol, activated charcoal,
i) Acute and maintenance treatment of schizophrenia within 5 - 7 days, adjust by 5 - 10 mg/day at 1 week
hypovolaemia, dehydration, risk of aspiration mouth, postural hypotension, elevated liver ethanol, central alpha-2 agonists, cimetidine,
Olanzapine 10 mg Disintegrating and other psychoses where positive and or negative intervals, maximum 20 mg/day ii) 10 - 15 mg once daily, Hypersensitivity to olanzapine products, narrow
Zyprexa Zydis pneumonia, hyperglycemia and diabetes mellitus. transaminases, hyperglycaemia, diabetic epinephrine, muscle relaxants, tricyclic
Tablet symptoms are prominent ii) Short-term use for acute increase by 5 mg/day at intervals of not less than 24 angle glaucoma, lactation
Elevated ALT and or AST, hepatic impairment, ketoacidosis . weight gain, dizziness, increased antidepressants. May antagonise the effects of
mania episodes associated with Bipolar 1 disorder hours. Maintenance 5 - 20 mg/day; maximum 20
limited hepatic functional reserve, seizures, low appetite, orthostatic hypotension, dry mouth, dopamine agonist. Other centrally-acting drugs
mg/day
leukocyte/neutrophil counts, history or existing bone constipation, tardive dyskinesia including alcohol. Activated charcoal
marrow depression, hypereosinophilic conditions,
myeloproliferative disease; prostatic hypertrophy,
paralytic ileus. Pregnancy and lactation. May impair
ability to drive or operate machinery
GI obstruction, paralytic ileus, cerebrovascular Somnolence, agitation, dizziness, constipation, Carbamazepine, ciprofloxacin, fluvoxamine,
disease, elderly, hypotension, hypovolaemia, drowsiness, weight gain, peripheral oedema, dry levodopa, haloperidol, activated charcoal,
dehydration, risk of aspiration mouth, postural hypotension, elevated liver ethanol, central alpha-2 agonists, cimetidine,
and other psychoses where positive and or negative intervals, maximum 20 mg/day ii) 10 - 15 mg once daily, Hypersensitivity to olanzapine products, narrow
Olanzapine 10 mg Tablet Zyprexa pneumonia,hyperglycemia and diabetes mellitus. transaminases, hyperglycaemia, diabetic epinephrine, muscle relaxants, tricyclic
symptoms are prominent ii) Short-term use for acute increase by 5 mg/day at intervals of not less than 24 angle glaucoma, lactation
Elevated ALT &/or AST, hepatic impairment; limited ketoacidosis . weight gain, dizziness, increased antidepressants. May antagonise the effects of
hepatic functional reserve; seizures; low appetite, orthostatic hypotension, dry mouth, dopamine agonist. Other centrally-acting drugs
mg/day
leukocyte/neutrophil counts; history or existing bone constipation, tardive dyskinesia including alcohol. Activated charcoal
marrow depression; hypereosinophilic conditions;
paralytic ileus. Pregnancy & lactation. May impair
GI obstruction, paralytic ileus, cerebrovascular Somnolence, agitation, dizziness, constipation, Carbamazepine, ciprofloxacin, fluvoxamine,
disease, elderly, hypotension, hypovolaemia, drowsiness, weight gain, peripheral oedema, dry levodopa, haloperidol, activated charcoal,
dehydration, risk of aspiration mouth, postural hypotension, elevated liver ethanol, central alpha-2 agonists, cimetidine,
Olanzapine 5 mg Tablet Zyprexa pneumonia,hyperglycemia and diabetes mellitus. transaminases, hyperglycaemia, diabetic epinephrine, muscle relaxants, tricyclic
Elevated ALT &/or AST, hepatic impairment; limited ketoacidosis . weight gain, dizziness, increased antidepressants. May antagonise the effects of
hepatic functional reserve; seizures; low appetite, orthostatic hypotension, dry mouth, dopamine agonist. Other centrally-acting drugs
mg/day
leukocyte/neutrophil counts; history or existing bone constipation, tardive dyskinesia including alcohol. Activated charcoal
marrow depression; hypereosinophilic conditions;
paralytic ileus. Pregnancy & lactation. May impair
gastrointestinal obstruction, paralytic ileus, Somnolence, agitation, dizziness, constipation, Carbamazepine, ciprofloxacin, fluvoxamine,
cerebrovascular disease, elderly, hypotension, drowsiness, weight gain, peripheral oedema, dry levodopa, haloperidol, activated charcoal,
hypovolaemia, dehydration, risk of aspiration mouth, postural hypotension, elevated liver ethanol, central alpha-2 agonists, cimetidine,
Olanzapine 5mg Disintegrating Tablet Zyprexa Zydis pneumonia, hyperglycemia and diabetes mellitus. transaminases, hyperglycaemia, diabetic epinephrine, muscle relaxants, tricyclic
Elevated ALT and or AST, hepatic impairment, ketoacidosis, weight gain, dizziness, increased antidepressants. May antagonise the effects of
limited hepatic functional reserve, seizures, low appetite, orthostatic hypotension, dry mouth, dopamine agonist. Other centrally-acting drugs
mg/day
leukocyte/neutrophil counts, history or existing bone constipation, tardive dyskinesia including alcohol. Activated charcoal
marrow depression, hypereosinophilic conditions,
myeloproliferative disease, prostatic hypertrophy,
paralytic ileus. Pregnancy and lactation. May impair
Olive Oil Ear Drops Impacted wax softener 3 - 4 drops 3 - 4 or as directed Perforated ear drum Not known Not known Not known
Headache, asthenia, burning or stinging, cold
Olopatadine HCl 0.1% Opthalmic Temporary prevention of ocular itching due to allergic ADULT and CHILD over 3 years old: 1-2 drops twice syndrome, dry eye, foreign body sensation, Hypersensitivity to Olopatadine HCl or any other
Patanol Pregnancy, lactation Not known
Solution conjunctivitis daily. Maximum duration of treatment: 4 months hyperemia, keratitis, lid edema, pharyngitis, ingredient of the products
pruritis, rhinitis, sinusitis, taste perversion
i)20 - 80 mg 1 - 2 times daily up to 8 - 12 weeks ii)20
mg twice daily in combination with any of the 2
Only for : i)Reflux oesophagitis ii)For eradication of antibiotics (clarithromycin 500 mg twice daily, Proton pump inhibitors reduce gastric acidity and
Gastrointestinal effects such as diarrhoea, May prolong elimination of diazepam, warfarin
Helicobacter pylori infection iii)Benign peptic ulcer not amoxicillin 1 g twice daily or metronidazole 400 mg increase the risk of gastrointestinal infections. It may Hypersensitivity to omeprazole or to any of its
Omeprazole 10 mg Capsule Losec nausea and constipation, headache, cough, and phenytoin. Increases plasma concentration
responding to conventional therapy iv)Zollinger-Ellison twice daily)for 1 - 2 weeks iii) 20 mg once daily for 4 - 6 mask symptoms of gastric cancer (exclude components
upper respiratory tract infection, rash of clarithromycin, ketoconazole
Syndrome weeks iv) ADULT: 20 - 120 mg once daily adjusted malignancy in suspected gastric ulcers)
according to the patient's response. CHILD 0.4 - 0.8
mg/kg/day
i)20 - 80 mg 1 - 2 times daily up to 8 - 12 weeks ii)20
mg twice daily in combination with any of the 2
Only for : i)Reflux oesophagitis ii)For eradication of antibiotics (clarithromycin 500 mg twice daily, Proton pump inhibitors reduce gastric acidity and
Gastrointestinal effects such as diarrhoea, May prolong elimination of diazepam, warfarin
Helicobacter pylori infection iii)Benign peptic ulcer not amoxicillin 1 g twice daily or metronidazole 400 mg increase the risk of gastrointestinal infections. It may Hypersensitivity to omeprazole or to any of its
Omeprazole 20 mg Capsule Losec nausea and constipation, headache, cough, and phenytoin. Increases plasma concentration
responding to conventional therapy iv)Zollinger-Ellison twice daily)for 1 - 2 weeks iii) 20 mg once daily for 4 - 6 mask symptoms of gastric cancer (exclude components
upper respiratory tract infection, rash of clarithromycin, ketoconazole
Syndrome weeks iv) ADULT: 20 - 120 mg once daily adjusted malignancy in suspected gastric ulcers)
according to the patient's response. CHILD 0.4 - 0.8
mg/kg/day
i) Reflux oesophagitis, eradication of H. Pylori infection, Proton pump inhibitors reduce gastric acidity &
i) 40 mg IV once daily when oral therapy is GI effects such as diarrhoea, nausea & May prolong elimination of diazepam, warfarin &
benign peptic ulcer not responding to conventional increase the risk of GI infections. It may mask Hypersensitivity to omeprazole or to any of its
Omeprazole 40 mg Injection Losec inappropriate ii) 40- 160 mg by IV in single or divided constipation, headache, cough, upper respiratory phenytoin. Increases plasma concentration of
therapy, Zollinger-Ellison Syndrome ii) Endoscopically symptoms of gastric cancer (exclude malignancy in components
doses tract infection, rash clarithromycin, ketoconazole
confirmed peptic ulcer suspected gastric ulcers)
i)8 mg 1 - 2 hours before treatment then 8 mg every 12
Headache, malaise, fatique, sedation, diarrhea, In patients treated with potent inducers of
hours for up to 5 days. CHILD, treatment by infusion
constipation, anaphylaxis sensation of flushing or CYP3A4 (ie phenytoin, carbamazepine and
i)Prevention of nausea and vomiting induced by followed by 4 mg by mouth every 12 hours for up to 5
Pregnancy, lactation, hepatic impairment. May mask warmth in the head and epigastrium, Hypersensitivity to any component of the rifampicin), the oral clearance of ondansetron
Ondansetron 4 mg Tablet Zofran chemotherapy and radiotherapy ii) Postoperative days ii)Prevention of postoperative nausea and
progressive ileus and/or gastric distension occasionally transient visual disturbances and preparation or other selective 5-HT3 antagonists was increased and ondansetron blood
nausea and vomiting vomiting, 16 mg 1 hour before anaesthesia or 8 mg 1
dizziness, involuntary movements, seizures and concentrations were decreased. Ondansetron
hour before anaesthesia followed by 8 mg at intervals
arrhythmias may reduce the analgesic effect of tramadol
of 8 hours for a further 2 doses
i)8 mg given by IV infusion over 15 minutes or by IM
immediately before treatment followed by 8 mg orally
every 12 hours for up to 5 days. CHILD 5 mg/m2 body
surface IV over 15 minutes immediately before
constipation, anaphylaxis sensation of flushing or CYP3A4 (ie, phenytoin, carbamazepine and
i)Prevention of nausea and vomiting induced by chemotherapy followed by 4 mg orally every 12 hours
Ondansetron 4 mg/2ml Injection Zofran chemotherapy and radiotherapy ii)Postoperative for up to 5 days ii)Prevention : 4 mg given by IV at
nausea and vomiting induction of anaesthesia. CHILD over 2 years, 100
mcg/kg (max 4mg) by slow IV before, during or after
induction of anaesthesia. Treatment of postoperative: 4
mg by IM or slow. CHILD over 2 years 100 mcg/kg
(maximum 4mg) by slow IV
i)8 mg 1 - 2 hours before treatment then 8 mg every 12
hours for up to 5 days. CHILD, treatment by infusion
constipation, anaphylaxis sensation of flushing or CYP3A4 (ie phenytoin, carbamazepine and
i)Prevention of nausea and vomiting induced by followed by 4 mg by mouth every 12 hours for up to 5
Ondansetron 8 mg Tablet Zofran chemotherapy and radiotherapy ii) Postoperative days ii)Prevention of postoperative nausea and
nausea and vomiting vomiting, 16 mg 1 hour before anaesthesia or 8 mg 1
hour before anaesthesia followed by 8 mg at intervals
of 8 hours for a further 2 doses
i)8 mg given by IV infusion over 15 minutes or by IM
immediately before treatment followed by 8 mg orally
every 12 hours for up to 5 days. CHILD 5 mg/m2 body
surface IV over 15 minutes immediately before
constipation, anaphylaxis sensation of flushing or CYP3A4 (ie, phenytoin, carbamazepine and
i)Prevention of nausea and vomiting induced by chemotherapy followed by 4 mg orally every 12 hours
Ondansetron 8 mg/4ml Injection Zofran chemotherapy and radiotherapy ii)Postoperative for up to 5 days ii)Prevention : 4 mg given by IV at
nausea and vomiting induction of anaesthesia. CHILD over 2 years, 100
mcg/kg (max 4mg) by slow IV before, during or after
induction of anaesthesia. Treatment of postoperative: 4
mg by IM or slow. CHILD over 2 years 100 mcg/kg
(maximum 4mg) by slow IV
ADULT: 200 - 400 ml ( 1 - 2 sachets ) for every loose
motion. CHILD: 200 ml (1 sachet) for every loose Cardiac failure, hypertension, impaired renal
Oral Rehydration Salt - Replacement of fluid and electrolytes loss in diarrhoea motion. In severe dehydration 100 ml/kg for 3 - 4 hours. function, peripheral and pulmonary oedema, Hypernatremia, nausea and vomiting Patients with renal failure or hyperkalaemia Potassium sparing diuretics
INFANT: 1 - 1.5 times their usual feed volume (50 ml toxaemia in pregnancy
per stool for small infant)
Initially 150 mg daily in divided doses. Maximum: 400 Tachycardia, cardiac decompensation, coronary Nausea, vomiting, blurred vision, rarely rash or Glaucoma, prostatic hypertrophy or bladder neck
Orphenadrine 100 mg Tablet Norflex Painful muscle spasm Not known
mg daily insufficiency, cardiac arrhythmias, pregnancy drowsiness, dry mouth obstruction, myasthenia gravis
Irritation to skin, eyes and mucous membranes. Must
Manual reprocessing, at least 12 minute immersion
wear personal protective equipment. Preparation For reprocessing of urological instruments used
time at room temperature (20 degree celcius) is Nausea, vomiting, diarrhoea, dermatitis, itching,
High level disinfectant for sensitive endoscopes or semi- room must be well ventilated. Reuse period not to on patients with history of bladder cancer. May Strong acids, strong alkaline, strong oxidizing
Ortho-phthalaldehyde 0.55% Solution Cidex Opa required. Automatic endoscope reprocessor, at least 5 eye conjunctivitis, stinging or excess tearing and
critical reusable medical devices exceed 14 days. Do not use on critical medical result in anaphylactic-like reaction in bladder agents
minute immersion time at a minimum of 25 degree asthma
devices that are intended for use in a sterile area of cancer patients undergoing repeated cystoscopy
celcius is required
the body (e.g. cataract surgical instruments)
chemotherapy with 5-fluorouracil-based regime ii) have Presence or history of peripheral neuropathy, pre- Anaphylactic, anaemia, dyspnoea, febrile
Hypersensitivity to oxaliplatin, pregnancy,
progressive disease despite 5-fluorouracil existing renal or hepatic impairment, significant bone neutropenia, thrombocytopenia, fatigue, fever, Drugs with potential neurological toxicity,
Oxaliplatin 50 mg Injection Eloxatin 85 mg/m2 IV repeated every 2 weeks lactation, bone marrow suppression, hepatic
chemotherapy for advanced disease iii) good marrow suppression may cause pulmonary fibrosis, nausea, diarrhoea, colitis, increased liver docetaxel, paclitaxel, aminoglycosides
impairment
performance status (WHO of 2 or less). The treatment avoid extravasation enzymes, dyspnoea
ADULT: Initially 2.5 - 5 mg 2 - 3 times daily increased if Glaucoma, gastrointestinal obstruction, paralytic
For the relief of symptoms of bladder instability necessary to maximum 5 mg 4 times daily. ELDERLY: High temperature, elderly, autonomic neuropathy, ileus, intestinal atony, megacolon, toxic
Side effects enhanced by antidepressants,
associated with voiding in patients with uninhibited Initially 2.5 - 3 mg twice daily, increased to 5 mg twice ileus, ulcerative colitis, hyperthyroidism, chronic Dry mouth, blurred vision, tachycardia, dizziness, megacolon, ulcerative colitis, severe colitis,
Oxybutynin Chloride 5 mg Tablet Ditropan antipsychotics, antihistamine, anti-parkinsonian
neurogenic or reflex neurogenic bladder (ie urgency, daily according to response and tolerance. CHILD over heart disease, prostatic hypertrophy, reflux impotence, skin reactions, restlessness myasthenia gravis, obstructive uropathy,
drugs
frequency, urinary leakage, urge incontinence, dysuria) 5 years, neurogenic bladder instability: 2.5 - 3 mg twice oesophagitis unstable cardiovascular status in acute
daily increased to 5 mg twice daily haemorrhage
History or tendency for drug abuse. Risk of criminal

diversion similar to morphine; obstructive pulmonary
disease or cor pulmonale, substantial decrease in
respiratory reserve, hypoxia, hypercapnia, pre-
existing respiratory depression or kyphoscoliosis
associated with respiratory depression (increased Acute or severe bronchial asthma or
risk for respiratory depression); circulatory shock, hypercarbia, hypersensitivity to oxycodone,
hypovolemia, concurrent use with other drugs which paralytic ileus, respiratory depression. Acute
Anticholinergics, antihypertensives, CNS
may decrease blood pressure; concomitant respiratory depression, cor pulmonale, cardiac
depressants including sedatives or hypnotics,
administration with central nervous system GI and CNS disturbances, bronchospasm, arrhythmias, acute asthma or other obstructive
ADULT, ELDERLY and CHILDREN more than 18 general anaesthetics, phenothiazines, other
Management of moderate to severe chronic cancer depressants; elderly or debilitated patients (greater dyspnoea, pharyngitis, voice alteration, airways disease, paralytic ileus, suspected
years, opioid-naive patients: 10 mg 12 hourly. Renal or tranquillizers, alcohol, other opioids &
Oxycodone HCl 10 mg Prolonged pain non-responsive to morphine (in accordance with risk of respiratory depression); head injury, orthostatic hypotension, rash, sweating, pruritus, surgical abdomen, severe renal impairment,
Oxycontin hepatic impairment: 5 mg 12 hourly. Titrate dose neuroleptics; muscle relaxants, coumarin
Release Tablet WHO step-wise ladder of chronic pain management) increased intracranial pressure, central nervous fever and chills, constipation, xerostomia, delayed gastric emptying, acute alcoholism,
carefully, as frequently as once a day if necessary, to derivatives, metoclopramide, MAOIs,
[Initiated by Chronic Pain Specialist only] system depression or coma; acute abdominal asthenia, dizziness, sedated, apnoea, respiratory brain tumour, increased cerebrospinal or
achieve pain relief neuromuscular blockers, opioid analgesics,
conditions; acute alcoholism, delirium tremens; arrest, respiratory depression intracranial pressure, head injury, severe CNS
drugs that involve cytochrome P450 enzyme
Addison?s disease; iliary tract disease, including depression, convulsive disorders, delirium
system eg CYP3A4, CYP2D6
acute pancreatitis. Hypothyroidism, biliary tract tremens, hypercarbia. Concurrent MAOIs (or
disease, pancreatitis, inflammatory bowel disorders, within 2 weeks). Pre-operative or within 24 hours
prostatic hypertrophy, adrenocortical insufficiency; post-operative. Lactation
renal/hepatic disease; 24 hours prior to cordotomy or
other pain relieving surgery; abdominal surgery,
chronic non-malignant pain. Avoid abrupt cessation
of prolonged use & therapy. May impair ability to
drive or operate machinery. Pregnancy
History or tendency for drug abuse. Risk of criminal

diversion similar to morphine; obstructive pulmonary
disease or cor pulmonale, substantial decrease in
respiratory reserve, hypoxia, hypercapnia, pre-
existing respiratory depression or kyphoscoliosis
associated with respiratory depression (increased Acute or severe bronchial asthma or
risk for respiratory depression); circulatory shock, hypercarbia, hypersensitivity to oxycodone,
hypovolemia, concurrent use with other drugs which paralytic ileus, respiratory depression. Acute
Anticholinergics, antihypertensives, CNS
may decrease blood pressure; concomitant respiratory depression, cor pulmonale, cardiac
depressants including sedatives or hypnotics,
administration with central nervous system GI and CNS disturbances, bronchospasm, arrhythmias, acute asthma or other obstructive
ADULT, ELDERLY and CHILDREN more than 18 general anaesthetics, phenothiazines, other
Management of moderate to severe chronic cancer depressants; elderly or debilitated patients (greater dyspnoea, pharyngitis, voice alteration, airways disease, paralytic ileus, suspected
years, opioid-naïve patients: 10 mg 12 hourly. Renal or tranquillizers, alcohol, other opioids &
Oxycodone HCl 20 mg Prolonged pain non-responsive to morphine (in accordance with risk of respiratory depression); head injury, orthostatic hypotension, rash, sweating, pruritus, surgical abdomen, severe renal impairment,
Oxycontin hepatic impairment: 5 mg 12 hourly. Titrate dose neuroleptics; muscle relaxants, coumarin
Release Tablet WHO step-wise ladder of chronic pain management) increased intracranial pressure, central nervous fever and chills, constipation, xerostomia, delayed gastric emptying, acute alcoholism,
carefully, as frequently as once a day if necessary, to derivatives, metoclopramide, MAOIs,
[Initiated by Chronic Pain Specialist only] system depression or coma; acute abdominal asthenia, dizziness, sedated, apnoea, respiratory brain tumour, increased cerebrospinal or
achieve pain relief neuromuscular blockers, opioid analgesics,
conditions; acute alcoholism, delirium tremens; arrest, respiratory depression intracranial pressure, head injury, severe CNS
drugs that involve cytochrome P450 enzyme
Addison?s disease; iliary tract disease, including depression, convulsive disorders, delirium
system eg CYP3A4, CYP2D6
acute pancreatitis. Hypothyroidism, biliary tract tremens, hypercarbia. Concurrent MAOIs (or
disease, pancreatitis, inflammatory bowel disorders, within 2 weeks). Pre-operative or within 24 hours
prostatic hypertrophy, adrenocortical insufficiency; post-operative. Lactation
renal/hepatic disease; 24 hours prior to cordotomy or
other pain relieving surgery; abdominal surgery,
chronic non-malignant pain. Avoid abrupt cessation
of prolonged use & therapy. May impair ability to
drive or operate machinery. Pregnancy
After local use of oxymetazoline transient
irritation may occur. Rebound congestion may Skin and mucosal inflammation of the nasal Anticholinergic, beta blockers, linezolid,
Cardiovascular disease, diabetes mellitus,
Oxymetazoline HCl 0.025% 1 - 2 drops twice daily in each nostril for child more than occur after frequent or prolonged nasal use. vestibules with incrustation, narrow angle methylphenidate, tricyclic antidepressants,
Afrin, Iliadin Acute colds, paranasal sinusitis and otitis media hypertension, prostatic enlargement, prolonged use
(Paediatric) Nasal Drops 1 year Systemic effects have occurred after local glaucoma, hypersensitivity to oxymetazoline or hypertensive crisis if used during treatment with
over 3 to 5 days, thyroid disease
administration, burning, sneezing, nasal dryness, other adrenergic agents MAOI
hypertension
Oxymetazoline HCl 0.025% 2 - 3 sprays into each nostril twice daily for child more occur after frequent or prolonged nasal use. vestibules with incrustation, narrow angle methylphenidate, tricyclic antidepressants,
(Paediatric) Nasal Spray than 1 year Systemic effects have occurred after local glaucoma, hypersensitivity to oxymetazoline or hypertensive crisis if used during treatment with
hypertension
Oxymetazoline HCl 0.05% (Adult) occur after frequent or prolonged nasal use. vestibules with incrustation, narrow angle methylphenidate, tricyclic antidepressants,
Afrin, Iliadin Acute colds, paranasal sinusitis and otitis media 1 - 2 drops twice daily in each nostril hypertension, prostatic enlargement, prolonged use
Nasal Drops Systemic effects have occurred after local glaucoma, hypersensitivity to oxymetazoline or hypertensive crisis if used during treatment with
hypertension
Oxymetazoline HCl 0.05% (Adult) 2 - 3 sprays into each nostril twice daily, maximum 6 occur after frequent or prolonged nasal use. vestibules with incrustation, narrow angle methylphenidate, tricyclic antidepressants,
Nasal Spray sprays per nostril/day Systemic effects have occurred after local glaucoma, hypersensitivity to oxymetazoline or hypertensive crisis if used during treatment with
hypertension
Mild hepatic dysfunction, congestive heart failure or
hypertension, patients with coronary artery disease, Hypersensitivity to oxymetholone products, male
ADULT and CHILD: 1 - 5 mg/kg daily in one daily dose.
previous myocardial infarction or lipid-lipoprotein breast or prostate cancer, metastatic female
Anaemias caused by the administration of myelotoxic Usual effective dose 1 - 2 mg/kg/day, given for a Oedema, hypertension, virilization, nausea and
Oxymetholone 50 mg Tablet Anapolon abnormalities. Renal function impairment, diabetes breast cancer with hypercalcaemia, nephrosis or Dicumarol, warfarin
drugs, treatment of AIDS-wasting syndrome minimum trial of 3 - 6 months because response may vomiting, hepatotoxicity
mellitus, benign prostatic hyperplasia, previous nephrotic phase of nephritis, known or suspected
be delayed
hypersensitivity to other androgens or anabolic pregnancy, severe liver disease
steroids and children
Conjunctivitis, dacryocystitis, blepharoconjunctivitis,
Oxytetracycline with Polymyxin B Prolonged use may enable overgrowth of non-
Terramycin keratitis, trachoma, blepharitis, pre-op prophylaxis Apply into the conjunctival sac 4 times daily Allergic reaction Hypersensitivity to any of the components Not known
Sulphate Eye Ointment susceptible organisms, including fungi
against infection
IV: 0.5 - 1 milliunits/minute; gradually increase dose in Hypersensitivity to oxytocin, significant
increments of 1 - 2 milliunits/minute until desired For induction or enhancement only as IV infusion, Gastrointestinal upsets, water intoxication cephalopelvic disproportion, unfavorable fetal
Prostaglandins, inhalation anaesthetics,
Oxytocin 10 units/ml Injection Pitocin Induction of labour contraction pattern is established; dose may be careful monitoring of fetal heart rate and uterine resulting from large amounts of solution or too positions, fetal distress, hypertonic or
vasoconstrictor agents
decreased after desired frequency of contractions is contractions are required rapid infusion, cardiac arrhythmias hyperactive uterus, contraindicated vaginal
reached and labor has progressed to 5 - 6 cm dilation delivery
Pregnancy, labour (except second stage

i) 1 ml IM, may be repeated after 2 hours. Should not
Hypertension, cardiac, hepatic or renal disease. Gastrointestinal upsets, abdominal pain, following delivery of the anterior shoulder),
exceed 3 ml within 24 hours ii) For routine management
Oxytocin 5 units & Ergometrine i) Prevention and treatment of post partum Should not be given until after delivery of child & in headache, dizziness, skin rashes. Rarely severe hypertension, pre-eclampsia, eclampsia, Vasoconstrictors, prostaglandins, halothane
Syntometrine of third stage of labour, 1 ml IM following delivery of the
Maleate 0.5 mg/ml Injection haemorrhage ii) Management of third stage of labour multiple births not until the last child has been hypertension, bradycardia, cardiac arrthymias, severe disorders of cardiac, hepatic or renal anaesthesia
anterior shoulder or immediately after delivery of the
delivered chest pain, anaphylactoid reactions function, occlusive vascular disease, sepsis and
child
in patients with a history of hypersensitivity
i) Treatment of recurrent breast cancer, after failure of
i) 175 mg/m2 IV over 3 hours every 3 weeks ii) 175 Severe neutropenia, severe hepatic impairment.
anthracycline-based chemotherapy ii) Primary adjuvant
mg/m2 IV over 3 hour followed by cisplatin 75 mg/m2 in Caution in patients with ischaemic heart disease, Alopecia, myelosuppression, severe History of hypersensitivity reaction to paclitaxel
therapy in advanced ovarian cancer in combination
every 3 weeks or 135 mg/m2 IV over 24 hours followed myocardial infarction and conduction defects. neutropenia, peripheral neuropathy, arrhythmias, or polyoxyethylated castor oil (Cremophor EL) or Doxorubicin, live vaccines, phenytoin,
Paclitaxel 100 mg/16.6 ml Injection Taxol / Anzatax with cisplatin iii) Treatment of locally advanced or
by cisplatin 75 mg/m2 every 3 weeks iii) 135 mg/m2 IV Taxane to be given first when used in combination hypotension, hypersensitivity reactions, any component of preparation. Pregnancy, ketoconazole, St John's Wort
metastatic non-small cell lung cancer (NSCLC) in
over 24 hours followed by cisplatin 75 mg/m2 every 3 with platinum analogue to avoid myelosuppression. arthralgia, myalgia lactation
chemonaive patients in combination with platinum
weeks Increased risk of infection by live vaccines
compounds
i) Treatment of recurrent breast cancer, after failure of
i) 175 mg/m2 IV over 3 hours every 3 weeks ii) 175 Severe neutropenia, severe hepatic impairment.
anthracycline-based chemotherapy ii) Primary adjuvant
mg/m2 IV over 3 hour followed by cisplatin 75 mg/m2 in Caution in patients with ischaemic heart disease, Alopecia, myelosuppression, severe History of hypersensitivity reaction to paclitaxel
therapy in advanced ovarian cancer in combination
every 3 weeks or 135 mg/m2 IV over 24 hours followed myocardial infarction and conduction defects. neutropenia, peripheral neuropathy, arrhythmias, or polyoxyethylated castor oil (Cremophor EL) or Doxorubicin, live vaccines, phenytoin,
Paclitaxel 30 mg/5 ml Injection Taxol / Anzatax with cisplatin iii) Treatment of locally advanced or
by cisplatin 75 mg/m2 every 3 weeks iii) 135 mg/m2 IV Taxane to be given first when used in combination hypotension, hypersensitivity reactions, any component of preparation. Pregnancy, ketoconazole, St John's Wort
metastatic non-small cell lung cancer (NSCLC) in
over 24 hours followed by cisplatin 75 mg/m2 every 3 with platinum analogue to avoid myelosuppression. arthralgia, myalgia lactation
chemonaive patients in combination with platinum
weeks Increased risk of infection by live vaccines
compounds
Neuroleptic malignant syndrome, tardive dyskinesia
Headache, tachycardia, akathisia, sinus
ADULT 6 mg once daily in the morning, adjusted if (discontinue use), diabetes mellitus, cerebrovascular
tachycardia, extrapyramidal disorder,
necessary; usual range 3 -12 mg daily. Renal disease or conditions predisposing to hypotension,
Paliperidone 3 mg Extended somnolence, dizziness, sedation, tremor, Lactation, hypersensitivity to Paliperidone, Centrally acting drugs, alcohol, levodopa,
Invega Second or third line treatment of schizophrenia impairment (creatinine clearance between 10-50 seizure, Parkinson's disease, conditions that
Released Tablet hypertonia, dystonia, orthostatic hypotension & Risperidone or to any product component dopamine agonists, itraconazole
mL/min) 3 mg once daily. Avoid if creatinine clearance contribute to core body temperature elevation or
dry mouth. Menstrual disturbances, erectile
less than 10mL/min dehydration, pregnancy, adolescent and children.
dysfunction, galactorrhoea and gynaecomastia
May impair ability to drive or operate machinery


Should be given with caution to patients with
For the prevention of serious lower respiratory tract Fever, nervousness, diarrhoea, vomiting, rhinitis,
thrombocytopenia or any coagulation disorder. Hypersensitivity to humanised monoclonal Carcinogenesis, mutagenesis and reproductive
Palivizumab 100mg Injection Synagis disease caused by respiratory syncytial virus (RSV) in 15 mg/kg IM once a month during season of RSV risk cough, wheeze, pain, rash, leucopenia,
Injection should be given within 6 hours after antibodies toxicity studies have not been performed
paediatric patients at high risk of RSV disease abnormal liver function tests
reconstitution
Myelosuppression, hypertension, hypotension,
thrombophlebitis, malaise, nausea, vomiting,
fever, anorexia, hypomagnesaemia,
Risk of hypocalcaemia especially in patients with hypokalaemia, hyperkalaemia, hypernatraemia,
Paget's disease, monitor if pre-existing anaemia, hypocalcaemia, hypophosphataemia, anaemia,
leucopenia, or thrombocytopenia are present, follow thrombocytopenia, lymphocytopenia, headache,
complete blood count during the first 2 weeks of insomnia, somnolence, conjunctivitis,
treatment, history of hypoparathyroidism. Do not hypertension, gastrointestinal disturbances, rash,
administer as a bolus injection or with other transient musculoskeletal pain, reactions at
bisphosphonates or calcium-containing IV infusions. infusion site, deterioration of preexisting renal Caution when coadministration with potentially
Pamidronate Disodium 30 mg Hypercalcaemia of malignancy (tumour -induced Dose depends on the initial serum calcium levels.
Aredia Monitor serum electrolytes, Calcium, phosphates, disease, acute renal failure, increased serum Hypersensitivity to biphosphonates nephrotoxic drugs. Combination with thalidomide
Injection hypercalcaemia) Doses range from a single infusion of 30 - 90 mg
renal function (at the start of treatment and prior to creatinine increased serum urea. Uncommon: may increase risk of renal dysfunction
each further dose). Renal impairment, cardiac allergic reactions, seizures, agitation, dizziness,
disease. Caution in road/machinery users. lethargy, uveitis, dyspepsia, pruritus, muscle
Pregnancy, lactation. Children. Severe hepatic cramps, abnormal liver function tests. Rare: focal
impairment. Patients should be advised to inform segmental glomerulosclerosis, nephrotic
their dentist while under treatment or if dental syndrome, anaphylactic shock, reactivation of
surgery is planned herpes simplex and zoster, leukopenia,
confusion, visual hallucinations, scleritis,
episcleritis, xanthopsia, left ventricular failure,
chronic heart failure, haematuria
Myelosuppression, hypertension, hypotension,

thrombophlebitis, malaise, nausea, vomiting,
fever, anorexia, hypomagnesaemia,
Risk of hypocalcaemia especially in patients with hypokalaemia, hyperkalaemia, hypernatraemia,
Paget's disease, monitor if pre-existing anaemia, hypocalcaemia, hypophosphataemia, anaemia,
leucopenia, or thrombocytopenia are present, follow thrombocytopenia, lymphocytopenia, headache,
complete blood count during the first 2 weeks of insomnia, somnolence, conjunctivitis,
treatment, history of hypoparathyroidism. Do not hypertension, gastrointestinal disturbances, rash,
administer as a bolus injection or with other transient musculoskeletal pain, reactions at
bisphosphonates or Calcium-containing IV infusions. infusion site, deterioration of preexisting renal Caution when coadministration with potentially
Pamidronate Disodium 90 mg Hypercalcaemia of malignancy (tumour -induced Dose depends on the initial serum calcium levels.
Aredia Monitor serum electrolytes, Calcium, phosphates, disease, acute renal failure, increased serum Hypersensitivity to biphosphonates nephrotoxic drugs. Combination with thalidomide
Injection hypercalcaemia) Doses range from a single infusion of 30 - 90 mg
renal function (at the start of treatment and prior to creatinine increased serum urea. Uncommon: may increase risk of renal dysfunction
each further dose). Renal impairment, cardiac allergic reactions, seizures, agitation, dizziness,
disease. Caution in road/machinery users. lethargy, uveitis, dyspepsia, pruritus, muscle
Pregnancy, lactation. Children. Severe hepatic cramps, abnormal liver function tests. Rare: focal
impairment. Patients should be advised to inform segmental glomerulosclerosis, nephrotic
their dentist while under treatment or if dental syndrome, anaphylactic shock, reactivation of
surgery is planned herpes simplex and zoster, leukopenia,
confusion, visual hallucinations, scleritis,
episcleritis, xanthopsia, left ventricular failure,
chronic heart failure, haematuria
Replacement or supplemental therapy for digestive Perioral and perianal irritation, skin rash,
Pancreatic Enzymes and Vitamins Hypersensitivity reaction to the ingredients Acarbose, cimetidine, ciprofloxacin, folic acid,
Enzyplex disorders associated with exocrine pancreatic 1 - 2 tablet with each meal Obstruction of the bile ducts gastrointestinal disturbance hyperuricaemia,
Tablet (porcine protein) ranitidine
insufficiency hyperuricosuria, uric acid crystalluria
Pregnancy, lactation. Do not mix with soft foods with
Treatment of pancreatic exocrine insufficiency due to a pH of greater than 5.5, doses greater than 6000 Diarrhoea, constipation, skin reactions, bloating,
Initially 1 - 2 capsules with each meal. May increase to Hypersensitivity to pork protein, early stages of
Pancreatin 150 mg Capsule Creon 10000 conditions such as cystic fibrosis, chronic pancreatitis units/kg/meal may be associated with fibrosing cramping, nausea, vomiting, hyperuricosuria, Not known
5 - 15 capsules daily acute pancreatitis
and non-pancreatic diseases colonopathy, irritation to perioral skin and buccal hyperuricemia perianal irritation
mucosa if retained in mouth
ADULT: Initially 50 - 100 mcg/kg IV, then 10 - 20
mcg/kg as required. CHILD: Initially 60 - 100 mcg/kg Pre-existing pulmonary and renal disease,
Increased activity with ether, halothane,
Pancuronium Bromide 4 mg/2 ml lnj Pavulon Muscle relaxant as an adjunct to general anaesthesia then 10 - 20 mcg/kg. NEONATE: 30 - 40 mcg/kg then pregnancy and neonate acidosis, severe electrolyte Local reaction at injection site Myasthenia gravis or myasthenic syndrome
isoflurane and cyclopropane
10 - 20 mcg/kg. Intensive care, by IV, 60 mcg/kg every disturbances
60 - 90 minutes
Gastrointestinal disturbances (nausea and
Proton pump inhibitors reduce gastric acidity and vomitting, diarrhoea, constipation, upper Pregnancy, lactation, moderate to severe hepatic May affect absorption of drugs which are pH-
40 mg twice daily until oral administration can be increase the risk of gastrointestinal infections. It may abdominal pain, flatulence) skin rash, pruritus, or renal impairment. Patients with known dependant in patients with known
Pantoprazole 40 mg Injection Controloc Bleeding peptic ulcer and acute stress ulceration
resumed. CHILD not recommended mask symptoms of gastric cancer (exclude dizziness, oedema, fever, depression, vision hypersensitivity to any component of the hypersensitivity to any component of the
malignancy in suspected gastric ulcers) disturbances, headache, liver enzyme changes, formulation formulation
raised triglycerides
i) 40 mg twice daily in combination with any of the 2
Gastrointestinal disturbances (nausea and
antibiotics (Clarithromycin 500 mg twice daily,
i) Helicobacter pylori eradication ii) Peptic ulcer disease Proton pump inhibitors reduce gastric acidity and vomitting, diarrhoea, constipation, upper Pregnancy, lactation, moderate to severe hepatic May affect absorption of drugs which are pH-
Amoxicillin 1 g twice daily or Metronidazole 400 mg
iii) Erosive and non-erosive reflux oesophagitis (GERD increase the risk of gastrointestinal infections. It may abdominal pain, flatulence) skin rash, pruritus, or renal impairment. Patients with known dependant in patients with known
Pantoprazole 40 mg Tablet Controloc twice daily) for 1-2 weeks ii) 40 mg daily for 2 - 4 weeks
and NERD) iv) Zollinger-Ellison Syndrome v) mask symptoms of gastric cancer (exclude dizziness, oedema, fever, depression, vision hypersensitivity to any component of the hypersensitivity to any component of the
iii) 20 - 40 mg daily on morning for 4 weeks iv) 40 mg
Prevention of NSAID induced gastropathy malignancy in suspected gastric ulcers) disturbances, headache, liver enzyme changes, formulation formulation
twice daily. Maximum: 240 mg daily v) 20 mg daily.
raised triglycerides
CHILD not recommended
Nausea, constipation, diarrhoea, anorexia,
Effects slightly potentiated by CNS depressants
Relief of cerebral and peripheral ischaemia associated headache, drowsiness, skin rash, sweating, dry
Papaverine HCl 120 mg/10ml ADULT: 30 - 120 mg may be repeated every 3 hours as and synergism when used with morphine. May
with arterial spasm and myocardial ischaemia Glaucoma, Parkinson's disease, pregnancy mouth/ throat, pruritus, vertigo, hypotension, Complete AV block
Injection necessary. CHILD: 6 mg/kg daily in 4 divided doses interfere with the therapeutic effect of levodopa in
complicated by arrhythmias slight blood pressure increased, increased depth
of respiration
CHILD: up to 1 year: 60 - 120 mg. 1 - 5 years: 120 -
240 mg. 6 - 12 years: 240 - 480 mg per dose. Repeat Anticoagulants, alcohol, liver enzyme inducers,
Paracetamol 120 mg/5 ml Syrup Panadol Mild to moderate pain and pyrexia Renal and hepatic failure. Avoid chronic use Allergic reactions, skin rash Nephropathy
every 4 - 6 hours when necessary. Maximum of 4 aspirin, chloramphenicol and phenobarbitone
doses in 24 hours
CHILD 1 - 5 years: 125 - 250 mg; 6 - 12 years: 250 -
500 mg; 3 - 11 months: 80 mg inserted every 4 - 6
Symptomatic relief of fever and post operative pain for hours if necessary, maximum 4 doses in 24 hours. Anticoagulants, alcohol, liver enzyme inducers,
Paracetamol 125 mg Suppository - Renal and hepatic failure. Avoid chronic use Allergic reactions, skin rash Nephropathy
paediatric cases INFANTS under 3 months should not be given aspirin, chloramphenicol and phenobarbitone
Paracetamol unless advised by doctor; a dose of 10
mg/kg (5 mg/kg if jaundiced) is suitable
CHILD 1 - 5 years : 125 - 250 mg; 6 - 12 years : 250 -
500 mg; 3 - 11 months : 80 mg inserted every 4 - 6
Symptomatic relief of fever and post operative pain for hours if necessary, maximum 4 doses in 24 hours. Anticoagulants, alcohol, liver enzyme inducers,
Paracetamol 250 mg Suppository - Renal and hepatic failure. Avoid chronic use Allergic reactions, skin rash Nephropathy
paediatric cases INFANTS under 3 months should not be given aspirin, chloramphenicol and phenobarbitone
Paracetamol unless advised by doctor; a dose of 10
mg/kg (5 mg/kg if jaundiced) is suitable
ADULT: 500 - 1000 mg every 4 - 6 hours, maximum of Anticoagulants, alcohol, liver enzyme inducers,
Paracetamol 500 mg Tablet Panadol Mild to moderate pain and pyrexia Renal and hepatic failure. Avoid chronic use Allergic reactions, skin rash Nephropathy
4 g daily aspirin, chloramphenicol and phenobarbitone
Paradichlorobenzene, Turpentine Oil Occlusion or partial occlusion of the external auditory Otitis externa, seborrhoeic dermatitis, eczema
Cerumol Instill 5 drops into the ears Not known Not known Not known
and Chlorbutol Ear Drops meatus by soft wax or wax plug affecting the external ear, perforated eardrums
Paraffin, White Soft Vaseline Xerosis and ichthyosis Apply to the affected area Avoid exposure to fire Hypersensitivity to any component Hypersensitivity to any component Not known
Paraffin, Yellow Soft Vaseline Xerosis and ichthyosis Apply to the affected area Avoid exposure to fire Hypersensitivity to any component Hypersensitivity to any component Not known
The usual intramuscular dose of paraldehyde for status
epilepticus is 0.15 to 0.3 milliliter/kilogram, a moderate
May be irritating to the throat, bronchopulmonary
additional dose (0.05 milliliter/kilogram) may be Hypotension, mental confusion, metabolic Hypersensitivity to paraldehyde products, lung or
Paraldehyde Injection - Status epilepticus disease, hepatic impairment, pregnancy, breast Disulfiram, alcohol
necessary. The dose may be repeated in 2 to 6 hours acidosis, dyspnoea, delirium, rashes hepatic disease, gastric disorders
feeding
and no more than 5 milliliters should be administered in
one site
Patients undergoing Coronary Bypass Grafting
Hypotension, back pain, dizziness, alveolar (CABG) procedures and patients with elevated
Moderate hepatic impairment, severe renal osteitis, ecchymosis, peripheral oedema, cardiovascular risk such as those with Warfarin, diuretics, antihypertensives, ACEI,
40 mg followed by 20 or 40 mg every 6 to 12 hours, as
impairment, pre-disposition to fluid retention, bradycardia , increased creatinine, congestive heart failure (NYHA II-IV), established ciclosporin, tacrolimus, fluconazole,
Management of post operative pain in the immediate required. Use limited to two days only with a maximum
Parecoxib Sodium 40mg Injection Dynastat coronary artery bypass graft surgery, dehydration, hypokalaemia, agitation, insomnia, ischaemic heart disease and or cerebrovascular ketoconazole, propafenone, metoprolol,
post operative setting only dose of 80 mg/day. Reduce the initial dose by 50% in
history of G1 perforations, ulcers or bleeds. Patients cerebrovascular disorders, Stevens-Johnson disease, patients who have experienced asthma, phenytoin, diazepam, lithium, CYP2C19
elderly less than 50 kg
with hypertension or with bleeding disorders Syndrome, pharyngitis oliguria erythema urticaria, or allergic-type reactions after taking substances
multiforme, acute renal failure acetylsalicylic acid, NSAIDs, COX-2 specific
inhibitors, hypersensitivity to sulphonamides
Administered as a slow (one hour) intravenous GI disturbances, muscle & or joint pains. G6PD deficiency. Allergy to drugs of the
Efficacy reduced by aluminium based antacids.
Infections due to gram-positive and gram-negative perfusion, after diluting the contents of the 400 mg in Avoid exposure to sunlight or ultra violet light. Adjust Neurological disturbances. With high dose, quinolone group. Children less than 15 years,
Pefloxacin 400 mg Injection Peflacine May potentiate theophylline effects. Coumarin
pathogens 250 ml 5% glucose (two perfusions daily, morning and dosage in severe hepatic insufficiency thrombocytopenia may occur. Photosensitivity, pregnancy, lactation, history of tendon lesions,
(monitor clotting times)
evening) tendinitis, ruptures of the Achilles tendon tendinitis or tendon rupture
GI disturbances, muscle & or joint pains. G6PD deficiency. Allergy to drugs of the
i) Infections due to gram-positive and gram-negative Efficacy reduced by aluminium based antacids.
Avoid exposure to sunlight or ultra violet light. Adjust Neurological disturbances. With high dose, quinolone group. Children less than 15 years,
Pefloxacin 400 mg Tablet Lexinor pathogens ii) Uncomplicated UTI, chancroid ADULT i) 800 mg/day in 2 divided doses ii) 800 mg stat May potentiate theophylline effects. Coumarin
dosage in severe hepatic insufficiency thrombocytopenia may occur. Photosensitivity, pregnancy, lactation, history of tendon lesions,
gonococcal urethritis (monitor clotting times)
tendinitis, ruptures of the Achilles tendon tendinitis or tendon rupture
Chronic liver disease, cardiovascular disease,
history of autoimmune disease, diabetes mellitus,
hypothyroidism or hyperthyroidism, renal
impairment, pregnancy, breast feeding, geriatric
i) Chronic hepatitis C usually in combination with Headache, alopecia, dermatitis, nausea,
patient, monitor CBC regularly. Baseline neutrophil
ribavirin (Important to establish hepatitis C virus (HCV) vomiting, abdominal pain, neutropenia, anaemia,
i) 180 mcg weekly with ribavirin 800 mg daily for 24 counts less than 1500 cells/mm3, baseline platelet
genotype and viral load where combination treatment is dyspnoea, myalgia, fatigue, rigors, fever,
weeks in patients in genotype 2 and 3 and 180 mcg counts less than 90,000 cells/mm3, baseline Hb less Hypersensitivity, autoimmune hepatitis,
advocated) ii) For the treatment of both HbeAg-positive depression, arthralgia, gastrointestinal
Peginterferon Alpha-2a 135 mcg weekly with ribavirin (1000 - 1200 mg) for 48 weeks for than 12 g/dL. Combination with myelosuppressive decompensated cirrhosis, severe psychiatric ACEI, fluorouracil, melphalan, prednisolone,
Pegasys and HbeAg-negative chronic hepatitis B with disturbances, irritability, flu-like symptoms,
Prefilled Syringe those with genotype 1 and 4. 135 mg dose may be agents. Autoimmune disorders, psoriasis, disorder, pregnancy and lactation. Neonate and theophylline, warfarin, zidovudine, didanosine
compensated liver disease and evidence of viral insomnia, asthenia, pharyngitis, weight loss,
used for patients who cannot tolerate the 180 mcg dose hypoglycemia, hyperglycemia, history of depression, infant three years and below
replication who are not responding or tolerating oral anorexia, dizziness, granulocytopenia,
ii) 180 mcg subcutaneously once a week for 48 weeks ophthalmic, cardiac or pulmonary disorders.
antiviral therapy (Initiated by Hepatologist and thrombocytopenia, injection site and acute
Discontinue use in patients who develop evidence of
Gasteroenterologist only) hypersensitivity reactions
hepatic decompensation. Perform standard
haematological and biochemical tests before and
periodically during therapy. May impair ability to
Chronic liver disease, cardiovascular disease,
history of autoimmune disease, diabetes mellitus,
hypothyroidism or hyperthyroidism, renal
impairment, pregnancy, breast feeding, geriatric
i) Chronic hepatitis C usually in combination with Headache, alopecia, dermatitis, nausea,
patient, monitor CBC regularly. Baseline neutrophil
ribavirin (Important to establish hepatitis C virus (HCV) vomiting, abdominal pain, neutropenia, anaemia,
i) 180 mcg weekly with ribavirin 800 mg daily for 24 counts less than 1500 cells/mm3, baseline platelet
genotype and viral load where combination treatment is dyspnoea, myalgia, fatigue, rigors, fever,
weeks in patients in genotype 2 and 3 and 180 mcg counts less than 90,000 cells/mm3, baseline Hb less Hypersensitivity, autoimmune hepatitis,
advocated) ii) For the treatment of both HbeAg-positive depression, arthralgia, gastrointestinal
Peginterferon Alpha-2a 180 mcg weekly with ribavirin (1000 - 1200 mg) for 48 weeks for than 12 g/dL. Combination with myelosuppressive decompensated cirrhosis, severe psychiatric ACEI, fluorouracil, melphalan, prednisolone,
Pegasys and HbeAg-negative chronic hepatitis B with disturbances, irritability, flu-like symptoms,
Prefilled Syringe those with genotype 1 and 4. 135 mg dose may be agents. Autoimmune disorders, psoriasis, disorder, pregnancy and lactation. Neonate and theophylline, warfarin, zidovudine, didanosine
compensated liver disease and evidence of viral insomnia, asthenia, pharyngitis, weight loss,
used for patients who cannot tolerate the 180 mcg dose hypoglycemia, hyperglycemia, history of depression, infant three years and below
replication who are not responding or tolerating oral anorexia, dizziness, granulocytopenia,
ii) 180 mcg subcutaneously once a week for 48 weeks ophthalmic, cardiac or pulmonary disorders.
antiviral therapy (Initiated by Hepatologist and thrombocytopenia, injection site and acute
Discontinue use in patients who develop evidence of
Gasteroenterologist only) hypersensitivity reactions
hepatic decompensation. Perform standard
haematological and biochemical tests before and
periodically during therapy. May impair ability to
Renal or hepatic impairment, diabetes, chronic heart
failure, myocardial infarction, arrhythmias,
Headache, myalgia, fatigue, insomnia,
pregnancy, lactation. Perform baseline and periodic
depression, dizziness, alopecia, pruritus, Hypersensitivity. Decompensated liver cirrhosis,
ECG in patients with preexisting cardiac
i) Combination therapy with Ribavirin: ADULT: SC 1.5 dermatitis, nausea, vomiting, abdominal pain, severe renal impairment (creatinine clearance
abnormalities. Discontinue if symptoms of pulmonary
mcg/kg/week CHILD and ADOLESCENT (3-17 yr): SC neutropenia, anaemia, dyspnoea, headache, less than 50 mL/minute), severe psychiatric ACE inhibitors, fluorouracil, mephalan,
Pegylated Interferon Alpha-2b 100 Treatment of: i) Chronic Hepatitis C ii) Chronic Hepatitis dysfunction or colitis occur, if neutrophil or platelet
Peg-Intron 60 mcg/m2/week for 24-48 weeks Monotherapy: rigors, fever, arthralgia, gastrointestinal conditions, autoimmune hepatitis, autoimmune prednisolone, theophylline, warfarin, zidovudine,
mcg Injection B counts are severely decreased or if pancreatitis
ADULT: SC 1 mcg/kg/week for 24 weeks to 1 year ii) disturbances, irritability, flu-like symptoms, disease, preexisting uncontrolled thyroid didanosine
diagnosed. Perform baseline and periodic standard
SC 1.0 - 1.5 mcg/kg once weekly for 24-52 weeks asthenia, pharyngitis, weight loss, anorexia, disease. Men whose female partners are
haematologic, blood chemistry and thyroid function
granulocytopenia, thrombocytopenia, injection pregnant
tests. Maintain adequate hydration. May affect ability
site and acute hypersensitivity reactions
to drive or operate machinery. Ensure adequate
contraception in women of childbearing potential
Pegylated Interferon Alpha-2b 50 mcg Treatment of: i) Chronic Hepatitis C ii) Chronic Hepatitis dysfunction or colitis occur, if neutrophil or platelet
Injection B counts are severely decreased or if pancreatitis
Pegylated Interferon Alpha-2b 80 mcg Treatment of: i) Chronic Hepatitis C ii) Chronic Hepatitis dysfunction or colitis occur, if neutrophil or platelet
Injection B counts are severely decreased or if pancreatitis
Nephrotoxic effects of pentamidine when given
Hypotension, hypoglycaemia, pancreatitis,
concomittantly with other nephrotoxic drugs or
cardiac arrhythmias, leucopenia,
sequentially, may be additive. Amiodarone,
thrombocytopenia, acute renal failure,
amitriptyline, astemizole, chloral hydrate,
hypocalcaemia, Stevens-Johnson syndrome,
Malnutrition, hyperglycaemia or hypoglycaemia, chloroquine, chlorpromazine, clarithromycin,
abnormal liver function tests, albuminuria, Pregnancy, lactation, hypersensitivity to
Pentamidine Isethionate 300 mg Only for the treatment of pneumonia due to 4 mg/kg once daily by slow IV infusion for at least 14 hepatic dysfunction, renal dysfunction, hypertension droperidol, enflurane, erythromycin, fluconazole,
Pentamidine nephrotoxicity, acute hypotension, pancreatitis, pentamidine or diamidine compounds, severe
Injection Pneumocytosis carinii days or hypotension, anaemia, leucopenia or fluoxetine, fluphenazine, haloperidol, halothane,
gastrointestinal disturbances, confusion, renal impairment
thrombocytopenia, renal impairment, pregnancy imipramine, isoflurane, mefloquine, octreotide,
hallucinations, arrhythmias, anaemia,
perphenazine, procainamide, prochlorperazine,
hyperkalaemia, rash, pain, local induration,
promethazine, propafenone, quetiapine,
sterile abscess and muscle necrosis at injection
quinidine, risperidone, sotalol, sulfamethoxazole,
site
trimethoprim, vasopressin
Gastrointestinal effects, hypersensitivity Cerebral haemorrhage, extensive retinal Increased risk of bleeding with ketorolac,
Hypotension, coronary artery disease, renal
Pentoxifylline 400 mg Tablet Trental Peripheral vascular disease 400 mg 2 - 3 times daily reactions, dizziness, agitation, sleep haemorrhage, acute myocardial infarction, possibly increased risk of bleeding with other
impairment, severe hepatic impairment
disturbances, headache pregnancy and lactation NSAIDs
Peracetic Acid and Hydrogen High level disinfectant or sterilant for heat labile Immersion time based on manufacturer
Perascope Avoid contact with skin and eyes Skin and eye irritation Not known Corrosive to aluminium, copper, brass and zinc
Peroxide endoscopes recommendation
Renal insufficiency especially when associated with

Bilateral renal artery stenosis or single Lithium, insulin, sulfonylureas, baclofen, NSAIDs,
systemic autoimmune collagen vascular diseases.
functioning kidney, severe renal failure high dose salicylates, tricyclic antidepressants,
Concomitant treatment with immunosuppressant or Headache, asthenia, dizziness, sleep
(creatinine clearance less than 30 mL/min), neuroleptics, corticosteroids, tetracosactide,
treatment causing leucopoenia. Marked sodium and disturbances, cramps, hypotension, rash,
dialysis patients, hepatic encephalopathy, severe potassium-sparing diuretics, potassium salts,
water depletion, hypotension, chronic heart failure, gastrointestinal disturbances, slight reversible
Perindopril 4 mg and Indapamide 1.25 hepatic impairment, hyperkalaemia or potassium-lowering drugs, anaesthesia,
Coversyl Plus Essential hypertension One tablet daily cirrhosis with oedema and ascites, ischemic heart increase in urea and plasma creatinine,
mg Tablet hypokalaemia, untreated decompensated allopurinol, immunosuppressant, cardiac
disease, cerebral circulatory insufficiency, severe hypokalaemia, hyponatraemia with
cardiac insufficiency. Previous history of glycosides, procainamide and other drugs which
cardiac insufficiency (grade IV) or IDDM patients. hypovolaemia, raised uric acid and blood
angioneurotic oedema linked to treatment with cause torsades de pointes, antihypertensive
Monitor serum potassium regularly. Surgery, elderly, glucose levels
ACE inhibitor, hereditary or idiopathic drugs, metformin, calcium salts, ciclosporin,
hyperaldosteronism, malnourishment, acute
angioneurotic oedema. Pregnancy and lactation iodinated contrast media
porphyria
Arterial hypotension, renal failure, water and sodium
depletion, renovascular hypertension, surgery or
i) 4 mg as single dose, may be increased to a single 8
anaesthesia, elderly. Haemodialysis, avoid
mg dose. ELDERLY: Start treatment with 2 mg dose. In
combination with highly permeable membranes
renal insufficiency, dose should be adapted according Potassium supplements or potassium-sparing
(polyacrylonitrile). Measure plasma creatinine at Angioedema induced by other angiotensin
to creatinine clearance ii) Single starting oral dose of 2 Gastrointestinal disorders, dizziness, diuretics may induce hyperkalaemia especially in
baseline and during the month following institution of converting enzyme (ACE) inhibitors.
i) Hypertension ii) Congestive heart failure iii) Stable mg should be increased to a single 4 mg once BP headaches, mood and or sleep disorders, renal failure. Neuroleptics or imipramine-like
Perindopril 4 mg Tablet Coversyl treatment. May precipitate excessive hypotension in Hypersensitivity to this or any other angiotensin
coronary artery disease acceptability has been demonstrated iii) 4 mg once asthenia, taste disorder, cramps, localized skin antidepressants increase risk of postural
severe chronic heart failure with or without converting enzyme inhibitor. Pregnancy (second
daily for 2 weeks, may be increased to 8 mg once daily. rashes, dry cough, angioneurotic oedema hypotension. Serum lithium concentrations may
associated renal insufficiency. Patients with and third trimesters particularly)
ELDERLY: 2 mg once daily for 1 week, then 4 mg once rise during lithium therapy
ischaemic heart disease or cerebrovascular disease
daily for the following week, may be increased up to 8
in whom excessive fall in blood pressure may result
mg once daily
in myocardial infarction or cerebrovascular accident,
hepatic impairment
Arterial hypotension, renal failure, water and sodium
depletion, renovascular hypertension, surgery or
i) 4 mg as single dose, may be increased to a single 8
anaesthesia, elderly. Haemodialysis, avoid
mg dose. ELDERLY: Start treatment with 2 mg dose. In
combination with highly permeable membranes
renal insufficiency, dose should be adapted according Potassium supplements or potassium-sparing
(polyacrylonitrile). Measure plasma creatinine at Angioedema induced by other angiotensin
to creatinine clearance ii) Single starting oral dose of 2 Gastrointestinal disorders, dizziness, diuretics may induce hyperkalaemia especially in
baseline and during the month following institution of converting enzyme (ACE) inhibitors.
i) Hypertension ii) Congestive heart failure iii) Stable mg should be increased to a single 4 mg once BP headaches, mood and or sleep disorders, renal failure. Neuroleptics or imipramine-like
Perindopril 8 mg Tablet treatment. May precipitate excessive hypotension in Hypersensitivity to this or any other angiotensin
coronary artery disease acceptability has been demonstrated iii) 4 mg once asthenia, taste disorder, cramps, localized skin antidepressants increase risk of postural
severe chronic heart failure with or without converting enzyme inhibitor. Pregnancy (second
daily for 2 weeks, may be increased to 8 mg once daily. rashes, dry cough, angioneurotic oedema hypotension. Serum lithium concentrations may
associated renal insufficiency. Patients with and third trimesters particularly)
ELDERLY: 2 mg once daily for 1 week, then 4 mg once rise during lithium therapy
ischaemic heart disease or cerebrovascular disease
daily for the following week, may be increased up to 8
in whom excessive fall in blood pressure may result
mg once daily
in myocardial infarction or cerebrovascular accident,
hepatic impairment
Generally, drugs of low molecular weight, high
water solubility, low volume of distribution, low
severe inflammatory bowel disease. Dialysis malnutrition and catheter complications. Long-
Peritoneal Dialysis with 1.5% Glucose For chronic renal disease requiring dialysis and for protein binding and high renal clearance are
- Dose depending on clinical cases solutions should be warmed to body temperature term peritoneal dialysis results in progressive Not known
Solution acute renal failure most extensively removed by dialysis eg
with dry heat because wet heat carries a risk of structural changes to the peritoneal membrane
Generally, drugs of low molecular weight, high
water solubility, low volume of distribution, low
severe inflammatory bowel disease. Dialysis malnutrition and catheter complications. Long-
Peritoneal Dialysis with 4.25% For chronic renal disease requiring dialysis and for protein binding and high renal clearance are
- Dose depending on clinical cases solutions should be warmed to body temperature term peritoneal dialysis results in progressive Not known
Glucose Solution acute renal failure most extensively removed by dialysis eg
with dry heat because wet heat carries a risk of structural changes to the peritoneal membrane
Blood concentrations of dialyzable drugs may be
reduced by dialysis. Dosage adjustment of
As a once replacement for a single glucose exchange Abdominal surgery within 30 days, concomitant
concomitant medications may be necessary. In
as part of a continuous ambulatory peritoneal dialysis Administered as a single daily exchange for the long conditions precluding normal nutrition, Peritonitis, high blood pressure, cold, rash,
Patients with a known allergy to cornstarch or patients using cardiac glycosides (digoxin and
Peritoneal Dialysis with 7.5% (CAPD) or automated peritoneal dialysis (APD) dwell in continuous ambulatory peritoneal dialysis or hypercalcemia, impaired respiratory function, insulin- headache, abdominal pain, cough, flu-like
Extraneal® icodextrin, or in patients with glycogen storage others), plasma levels of calcium, potassium and
Icodextrin Solution regimen for the treatment of chronic renal failure, automated peritoneal dialysis. The recommended dwell dependent diabetes, potassium deficiency. To symptoms, nausea, swelling, chest pain, upset
disease, acute renal failure magnesium must be carefully monitored. Falsely
particularly for patients who have lost ultra filtration on time is 8 to 16 hours reduce possible discomfort during administration, stomach, and high blood sugar
elevated blood glucose levels with the use of
glucose solutions solutions may be warmed prior to use
monitors and strips using glucose GDH-PQQ
based methods.
Apply thoroughly to all body parts. Leave on for 8 - 14
Swelling, erythema, pruritus, rash, stinging of Hypersensitivity to permethrin and other
Permethrin 5% w/v Lotion A-Scabs Treatment of scabies hours. Not recommended for children less than 2 years May exacerbate pruritus, oedema and erythema Not known
skin, burning sensation synthetic pyrethrin
old
Tramadol, increased risk of seizures. Cisapride,
levofloxacin, cardiotoxicity. Procyclidine,
CNS effects (extrapyramidal effects),
Concomitant epinephrine use, seizure disorder, decreased phenothiazine serum concentrations,
drowsiness, insomnia, convulsion, allergic
patients undergoing alcohol withdrawal, pregnancy decreased phenothiazine effectiveness,
reaction, tachycardia, postural hypotension,
and lactation, respiratory impairment secondary to enhanced anticholinergic effects (ileus,
dizziness, impaired glucose tolerance, tardive
pulmonary infection or chronic pulmonary disorders, hyperpyrexia, sedation, dry mouth). Pethidine,
dyskinesia, liver damage, nausea, vomiting, Blood dyscrasias, bone marrow suppression,
increased risk of tardive dyskinesia development in increase in central nervous system and
cardiac arrest, agranulocytosis, haemolytic subcortical brain damage, comatose/obtunded
ADULT: Initially 4 mg 3 times daily adjusted according older patients, sulfite hypersensitivity, history of respiratory depression. Levodopa, loss of
anaemia, hepatotoxicity, alter temperature patients, hypersensitivity to perphenazine
Perphenazine 4 mg Tablet Schizophrenia and other psychoses to response, maximum 24 mg daily. ELDERLY: 1/4 to neuroleptic malignant syndrome, patients with levodopa efficacy. Ethanol, increased central
regulation, neuroleptic malignant syndrome, GI products, severe liver disease, high doses of
1/2 adult dose. CHILD not recommended hepatic or renal impairment; cardiovascular disease, nervous system depression and an increased
disturbances, nasal congestion, antimuscarinic CNS depressants, hypersensitivity to
Parkinson's disease, epilepsy, depression, risk of extrapyramidal reactions. Class Ia and III
symptoms, cardiovascular symptoms, ECG perphenazine, lactation
myasthenia gravis, paralytic ileus, prostatic antiarrhythmics, beta 2 agonists,
changes, endocrine effects, blood dyscrasias,
hypertrophy, history of jaundice, blood dyscrasias. carbamazepine, central alpha 2 agonists,
photosensitisation, contact sensitisation, rashes,
May affect driving especially when first started, systemic corticosteroids, diuretics, lithium,
jaundice, corneal and lens opacities, purplish
elderly tricyclic antidepressants. MAOIs, antiepileptics.
pigmentation of the skin and eye
Avoid alcohol, kava kava, gotu kola, valerian &
St John's wort
Cimetidine: pethidine toxicity (respiratory
depression, central nervous system depression,
Respiratory depression, dizziness, sweating, hypotension). Isoniazid: hypotension and central
disorientation, hallucination,agitation, tremor, Hypersensitivity, concurrent use of MAOIs, nervous system depression. Moclobemide:
multifocal myoclonus, convulsion, intracranial lesions causing increased pressure, cardiovascular instability, hyperpyrexia, coma or
Gastrointestinal disturbances, hypotension, atrioventricular flutter, respiratory depression, possible serotonin syndrome (hypertension,
Cirrhosis, elderly, neonates, children, liver/renal
hypertension, bradycardia, urine retention, renal failure and a predisposition to convulsions hyperthermia, myoclonus, mental status
dysfunction, convulsive disorders, reduced cardiac
Lightheadedness, dizziness, sedation, sweating, or seizures. Head injury, brain tumour. Cardiac changes). Naltrexone: precipitation of opioid
output, cardiac infarction, cardiac disease,
ADULT: 0.5 - 2 mg/kg SC or IM every 3 - 4 hours if bizzare feeling, disorientation, hallucinations, arrhythmias. Concurrent use of MAOIs. Pre- withdrawal symptoms. Phenothiazines: increase
For relief of moderate to severe pain (medical and supraventricular tachycardia, pregnancy,
necessary. CHILD: by IM 0.5 - 2 mg/kg. Up to 1 year : 1- psychosis. Dry mouth, nausea, vomiting, eclampsia, eclampsia. Convulsive states. in central nervous system and respiratory
Pethidine HCl 100 mg/2 ml Injection - surgical), pre-anaesthetic medication and obstetrical lactation.May impair ability to drive or operate
2 mg/kg weight IM, 1 - 5 years : 12.5 - 25 mg IM, 6 - 12 constipation. Hypotension, vasodilation, Diabetic acidosis. Acute alcoholism or delerium depression. Phenytoin: decreased pethidine
analgesia machinery. Elderly. Reduced plasma protein binding.
years: 25 - 50 mg IM tachycardia, bradycardia, gangrene. Rash, tremens. Severe liver disease, incipient effectiveness. Procarbazine, selegiline: cardiac
Phaeochromocytoma. Hypothyroidism, Addison's
pruritus, urticaria, erythema, injection site encephalopathy, low platelet count, coagulation instability, hyperpyrexia, coma. Ritonavir:
disease. Prostatic hypertrophy, urethral stricture.
complications, anuria. Increased biliary tract disorders or receiving anticoagulant treatment. increased risk of central nervous system
Diabetes. Glaucoma
pressure, choledochoduodenal sphincter spasm. Continuous IV infusion in renal impairment. stimulation and excitation. Barbiturates, chloral
Neurotoxicity, neuropsychiatric toxicity. Patient-controlled analgesia in young children & hydrate, benzodiazepines. Butyrophenones,
Hyperactivity or agitation, depression, mental adult wiith poor cognitive function CNS depressants: pethidine enhances the CNS
clouding, dysphoria depressant effects of these drugs. MAOIs,
amphetamine reactions. Anticoagulants.
Reduces paracetamol absorption
Cimetidine: pethidine toxicity (respiratory

depression, central nervous system depression,
Respiratory depression, dizziness, sweating, hypotension). Isoniazid: hypotension and central
disorientation, hallucination,agitation, tremor, Hypersensitivity, concurrent use of MAOIs, nervous system depression. Moclobemide:
multifocal myoclonus, convulsion, intracranial lesions causing increased pressure, cardiovascular instability, hyperpyrexia, coma or
Gastrointestinal disturbances, hypotension, atrioventricular flutter, respiratory depression, possible serotonin syndrome (hypertension,
Cirrhosis, elderly, neonates, children, liver/renal
hypertension, bradycardia, urine retention, renal failure and a predisposition to convulsions hyperthermia, myoclonus, mental status
dysfunction, convulsive disorders, reduced cardiac
Lightheadedness, dizziness, sedation, sweating, or seizures. Head injury, brain tumour. Cardiac changes). Naltrexone: precipitation of opioid
output, cardiac infarction, cardiac disease,
ADULT: 0.5 - 2 mg/kg SC or IM every 3 - 4 hours if bizzare feeling, disorientation, hallucinations, arrhythmias. Concurrent use of MAOIs. Pre- withdrawal symptoms. Phenothiazines: increase
For relief of moderate to severe pain (medical and supraventricular tachycardia, pregnancy,
necessary. CHILD: by IM 0.5 - 2 mg/kg. Up to 1 year : 1- psychosis. Dry mouth, nausea, vomiting, eclampsia, eclampsia. Convulsive states. in central nervous system and respiratory
Pethidine HCl 50 mg/ml Injection - surgical), pre-anaesthetic medication and obstetrical lactation.May impair ability to drive or operate
2 mg/kg weight IM, 1 - 5 years : 12.5 - 25 mg IM, 6 - 12 constipation. Hypotension, vasodilation, Diabetic acidosis. Acute alcoholism or delerium depression. Phenytoin: decreased pethidine
analgesia machinery. Elderly. Reduced plasma protein binding.
years: 25 - 50 mg IM tachycardia, bradycardia, gangrene. Rash, tremens. Severe liver disease, incipient effectiveness. Procarbazine, selegiline: cardiac
Phaeochromocytoma. Hypothyroidism, Addison's
pruritus, urticaria, erythema, injection site encephalopathy, low platelet count, coagulation instability, hyperpyrexia, coma. Ritonavir:
disease. Prostatic hypertrophy, urethral stricture.
complications, anuria. Increased biliary tract disorders or receiving anticoagulant treatment. increased risk of central nervous system
Diabetes. Glaucoma
pressure, choledochoduodenal sphincter spasm. Continuous IV infusion in renal impairment. stimulation and excitation. Barbiturates, chloral
Neurotoxicity, neuropsychiatric toxicity. Patient-controlled analgesia in young children & hydrate, benzodiazepines. Butyrophenones,
Hyperactivity or agitation, depression, mental adult wiith poor cognitive function CNS depressants: pethidine enhances the CNS
clouding, dysphoria depressant effects of these drugs. MAOIs,
amphetamine reactions. Anticoagulants.
Reduces paracetamol absorption
Depression, renal impairment, pulmonary
Alcohol, antibacterial, warfarin, antidepressants,
ADULT: 60 - 180 mg daily on. CHILD: Up to 8 mg/kg insufficiency, elderly, avoid abrupt discontinuation, Hypersensitivity, rash, hypotension, drowsiness, Hypersensitivity to phenobarbital products,
Phenobarbitone 30 mg Tablet Luminal Epilepsy other antiepileptics, antipsychotics, antiviral,
daily pregnancy, breast feeding, porphyria, hyperactivity ataxia, respiratory depression, dyskinesias porphyria
ciclosporin
in children
ADULT: 10 mg/kg IV at a rate of not faster than 100
mg/minute. Initial maximum dose does not exceeding 1 Depression, renal impairment, pulmonary
Alcohol, antibacterial, warfarin, antidepressants,
Phenobarbitone Sodium 200 mg/ml gm. Daily maintenance of 1 - 4 mg/kg/day. CHILD: 10 - insufficiency, elderly, avoid abrupt discontinuation, Hypersensitivity, rash, hypotension, drowsiness, Hypersensitivity to phenobarbital products,
Gardenal Status Epilepticus other antiepileptics, antipsychotics, antiviral,
Injection 20 mg/kg/dose loading dose, followed by repeated pregnancy, breast feeding, porphyria, hyperactivity ataxia, respiratory depression, dyskinesias porphyria
ciclosporin
doses at 10 mg/kg/dose (strictly in ICU setting). in children
Maintenance 5 - 8 mg/kg/day
Solutions containing phenol should not be applied to
large areas of skin or large wounds since sufficient
Dermatitis and depigmentation appear to be the
phenol may be absorbed to give rise to toxic
Phenol 80% w/w Liquid - As disinfectant Use in various dilutions most common adverse effects. Diaphoresis may Hypersensitivity Not known
symptoms. Phenol should not be used as a throat
develop with systemic toxicity
spray in patients with epiglottitis or in children age
under six years
Alpha-adrenergic agonists decrease the effect of
Cerebral or coronary arteriosclerosis, concomitant
phenoxybenzamine. Beta-blockers may result in
administration with substances that stimulate alpha
increased toxicity (hypotension, tachycardia).
and beta receptors, hypotension and tachycardia
Phenoxybenzamine HCl 100 mg/2 ml Hypertensive episodes associated with 1 mg/kg daily over at least 2 hours. Do not repeat within Hypotension, sedation, nausea and vomiting, Sildenafil, tadalafil, vardenafil: Blood pressure-
Dibenyline may be amplified, renal impairment, respiratory Hypersensitivity to phenoxybenzamine
Injection phaeochromocytoma 24 hours sexual dysfunction, tachycardia lowering effects are additive. Use of vardenafil or
infection, pregnany, breast feeding, elderly,
tadalafil is contraindicated by the manufacturer.
congestive heart failure, severe heart disease,
Use sildenafil with extreme caution (dose ≤25
cerebrovascular disease
mg)
i) ADULT: 500 - 750 mg 6 hourly.CHILD; up to 1 year: Use cautiously in patients with penicillin or
62.5 mg, 1 - 5 years: 125 mg, 6 - 12 years: 250 mg 6 cephalosporin. Hypersensitivity reactions or asthma. Skin rashes, anaphylaxis, urticaria, fever, joint
Phenoxymethyl Penicillin 125 mg i) Treatment or prophylaxis of infections caused by Antirheumatics& antipyretics inhibit excretion.
Penicillin V hourly ii) ADULT: 125 - 250 mg twice daily. CHILD: 25 - Haematological& renal function test required on long- pain. Haemolytic anaemia, blood disorders, Hypersensitivity to penicillin
Tablet susceptible organisms ii) Prophylactic, rheumatic fever Neomycin may cause malabsorption
50 mg/kg in divided doses every 6 - 8 hours. Maximum: term treatment. Not for trivial infection. Renal or gastrointestinal distress& superinfection
3 g/day hepatic impairment
Use cautiously in patients with penicillin or
cephalosporin. Hypersensitivity reactions or asthma. Skin rashes, anaphylaxis, urticaria, fever, joint
Phenoxymethyl Penicillin 125 mg/5 ml Treatment or prophylaxis of infections caused by CHILD: Up to 1 year: 62.5 mg 6 hourly; 1 - 5 years: 125 Antirheumatics& antipyretics inhibit excretion.
Penicillin V Haematological & renal function test required on pain. Haemolytic anaemia, blood disorders, Hypersensitivity to penicillin
Syrup susceptible organisms mg 6 hourly; 6 - 12 years: 250 mg 6 hourly Neomycin may cause malabsorption
long-term treatment. Not for trivial infection. Renal or gastrointestinal distress& superinfection
hepatic impairment
i) ADULT: 500 - 750 mg 6 hourly.CHILD; up to 1 year: Use cautiously in patients with penicillin or
62.5 mg, 1 - 5 years: 125 mg, 6 - 12 years: 250 mg 6 cephalosporin. Hypersensitivity reactions or asthma. Skin rashes, anaphylaxis, urticaria, fever, joint
Phenoxymethyl Penicillin 250 mg i) Treatment or prophylaxis of infections caused by Antirheumatics& antipyretics inhibit excretion.
Penicillin V hourly ii) ADULT: 125 - 250 mg twice daily. CHILD: 25 - Haematological& renal function test required on long- pain. Haemolytic anaemia, blood disorders, Hypersensitivity to penicillin
Tablet susceptible organisms ii) Prophylactic, rheumatic fever Neomycin may cause malabsorption
50 mg/kg in divided doses every 6 - 8 hours. Maximum: term treatment. Not for trivial infection. Renal or gastrointestinal distress& superinfection
3 g/day hepatic impairment
Caution if administered with or up to 3 weeks after
Mydriasis and vasoconstriction: 1 drop of 2.5% or 10%
MAOI therapy. Infant with cardiac anomalies. To
solution, repeated in one hour if necessary. Chronic Narrow-angle glaucoma, infant, elderly with
prevent pain and subsequent lacrimation on
mydriasis: 1 drop of a 2.5% or 10% solution 2 - 3 times Marked increase in blood pressure in low-weight severe arteriosclerotic, cardiovascular or
For pupillary dilation in uveitis, for refraction without administration, a suitable topical anesthetic may be
a day. Uveitis with posterior synechiae (treatment) or neonates, infant and adult with idiopathic cerebrovascular disease. During intraocular
Phenylephrine HCI 2.5% Eye Drops Mydfrin cyclopegic. For fundoscopy and other diagnostic applied a few minutes before use of phenylephrine Tricyclic antidepressants, propranolol
synechiae, posterior (prophylaxis): 1 drop of a 2.5% or hypotension. Cardiovascular reactions in the operative procedures when corneal epithelial
procedures solution. Repeated use of phenylephrine, especially
10% solution, repeated in one hour if necessary, not to elderly barrier is disturbed. Not recommended for use in
in older patients, may result in rebound miosis and a
exceed three times a day. Treatment may be continued low birth weight infants
reduced mydriatic effect. Medication may cause
the following day, if necessary
increased sensitivity of eyes to light
Caution if administered with or up to 3 weeks after

Mydriasis and vasoconstriction: 1 drop of 2.5% or 10%
MAOI therapy. Infant with cardiac anomalies. To
solution, repeated in one hour if necessary. Chronic Narrow-angle glaucoma, infant, elderly with
prevent pain and subsequent lacrimation on
mydriasis: 1 drop of a 2.5% or 10% solution 2 - 3 times Marked increase in blood pressure in low-weight severe arteriosclerotic, cardiovascular or
For pupillary dilation in uveitis, for refraction without administration, a suitable topical anesthetic may be
a day. Uveitis with posterior synechiae (treatment) or neonates, infant and adult with idiopathic cerebrovascular disease. During intraocular
Phenylephrine HCl 10% Eye Drops - cyclopegic. For fundoscopy and other diagnostic applied a few minutes before use of phenylephrine Tricyclic antidepressants, propranolol
synechiae, posterior (prophylaxis): 1 drop of a 2.5% or hypotension. Cardiovascular reactions in the operative procedures when corneal epithelial
procedures solution. Repeated use of phenylephrine, especially
10% solution, repeated in one hour if necessary, not to elderly barrier is disturbed. Not recommended for use in
in older patients, may result in rebound miosis and a
exceed three times a day. Treatment may be continued low birth weight infants
reduced mydriatic effect. Medication may cause
the following day, if necessary
increased sensitivity of eyes to light
Nystagmus, ataxia, lethargy, blood dyscrasias,
Chloramphenicol, anticoagulants, diazepam,
cardiovascular toxicity, nausea, vomiting,
oestrogen, cimetidine, fluconazole etc may
headache, tremor, insomnia, gingival
increase serum levels. Methotrexate, folic acid,
hypertrophy, acne, lupus erythematosus,
carbamazepine, theophylline, etc may decrease
Stevens-Johnson syndrome, leukopenia,
ADULT and CHILD more than 6 years: 300-400 mg/day Avoid abrupt withdrawal, liver insufficiency, serum levels. Increased phenytoin serum levels
megaloblastic anaemia, hirsutism, hepatitis. Hypersensitivity to phenytoin or hydantoin
in 3 - 4 divided doses before meals. Maximum: 600 porphyria, discontinue if skin rash occurs, diabetes, with alcohol (acute intake), disulfiram,
Slurred speech, decreased coordination, mental products, sinus bradycardia, SA block, second
Phenytoin Sodium 100 mg Capsule Dilantin Epilepsy mg/day. CHILD: Initially 5 mg/kg/day in 2 - 3 divided elderly, pregnancy, breast feeding. Severe omeprazole, ticlopidine, salicylates, SSRIs,
confusion, constipation, toxic hepatitis, liver and third degree AV block and Adams-Stokes
doses. Maintenance: 4 - 8 mg/kg/day. Maximum: 300 myocardial insufficiency. Pregnancy. Potential for an benzodiazepines, antifungal agents, calcium
damage, hematopoietic complications, syndrome (intravenous phenytoin only)
mg/day increase in risk of suicidal thoughts or behaviours channel blockers. Decreased phenytoin serum
dermatological manifestations, agranulocytosis,
levels with alcohol (acute intake), rifampicin,
bullous dermatosis, granulocytopenic disorder,
ciprofloxacin, vigabatrin, sucralfate, theophylline,
liver damage, nephrotoxicity, pancytopenia,
reserpine, diazoxide, anticonvulsants,
purpuric rash, scaling eczema,
antineoplastics
thrombocytopenia, toxic epidermal necrolysis
Nystagmus, ataxia, lethargy, blood dyscrasias,
Phenytoin Sodium 125 mg/5ml Slurred speech, decreased coordination, mental products, sinus bradycardia, SA block, second
Dilantin Epilepsy mg/day. CHILD: Initially 5 mg/kg/day in 2 - 3 divided elderly, pregnancy, breast feeding. Severe omeprazole, ticlopidine, salicylates, SSRIs,
Suspension confusion, constipation, toxic hepatitis, liver and third degree AV block and Adams-Stokes
antineoplastics
thrombocytopenia,
Nystagmus, ataxia,toxic epidermal
lethargy, blood necrolysis
dyscrasias,
i) Status epilepticus: ADULT 10 - 15 mg/kg by slow IV. Avoid abrupt withdrawal, liver insufficiency, serum levels. Increased phenytoin serum levels
Maximum 50 mg/minute. Maintenance: 100 mg orally/IV porphyria, discontinue if skin rash occurs, diabetes, with alcohol (acute intake), disulfiram,
Phenytoin Sodium 250 mg/5ml Slurred speech, decreased coordination, mental products, sinus bradycardia, SA block, second
Dilantin Status epilepticus every 6 - 8 hours. CHILD 15 - 20 mg/kg by slow IV. elderly, pregnancy, breast feeding. Severe omeprazole, ticlopidine, salicylates, SSRIs,
Injection confusion, constipation, toxic hepatitis, liver and third degree AV block and Adams-Stokes
Maximum: 1 - 3 mg/kg/minute ii) Neurosurgery 100 - myocardial insufficiency. Pregnancy. Potential for an benzodiazepines, antifungal agents, calcium
200 mg IM approximately at 4 hourly interval increase in risk of suicidal thoughts or behaviours channel blockers. Decreased phenytoin serum
antineoplastics
thrombocytopenia,
Nystagmus, ataxia,toxic epidermal
lethargy, blood necrolysis
dyscrasias,
Slurred speech, decreased coordination, mental products, sinus bradycardia, SA block, second
Phenytoin Sodium 30 mg Capsule Dilantin Epilepsy mg/day. CHILD: Initially 5 mg/kg/day in 2 - 3 divided elderly, pregnancy, breast feeding. Severe omeprazole, ticlopidine, salicylates, SSRIs,
confusion, constipation, toxic hepatitis, liver and third degree AV block and Adams-Stokes
antineoplastics
thrombocytopenia, toxic epidermal necrolysis
Mild to moderate renal impairment, cirrhosis, heart
failure, other oedematous condition. Intravenous
phosphate therapy for hypophosphataemia is
indicated only in life-threatening situations.
Renal insufficiency, renal failure,
Phosphate Solution containing Concomitant use of antacids containing aluminum or Severe hypotension, hypocalcaemia, Antacids, incompatible with intravenous
For supplemental ionic phosphorus for correction of hyperphosphataemia, hypocalcaemia,
Sodium Acid Phosphate 1.936 g /15 Phosphate Sandoz According to the needs of the patient magnesium should be avoided, hypomagnesaemia extraskeletal calcification, hypomagnesaemia, admixtures- dextran 12%, dextran in dextrose or
hypophosphataemia hyperkalaemia, hypernatraemia, Addison's
ml can occur during intravenous phosphate therapy of diarrhoea, acute renal failure sodium chloride and dextrose
disease
hypophosphataemia. Patients with kidney stones
may pass old stones during phosphate therapy. Do
not administer laxatives when nausea, vomiting or
abdominal pain is present
May potentiate insulin and antidiabetic drugs,

Phyllanthus Niruri Extract 250 mg 2 capsules to be taken orally, 3 times a day, before or anti-hypertensive drugs, beta-blocker drugs and
Hepar-P Liver tonic Not known Minor gastric irritation, nausea and vomiting Pregnancy, lactation and hypoglycaemic patient
Capsule after meals other heart medications (including chronotropic
and inotropic drugs) and diuretics
Pilocarpine 1% Eye Drops - Miotics in chronic open-angle glaucoma 1 drop 1 - 4 times a day and those receiving long-term treatment with a burning, itching, smarting, blurred vision, anterior uveitis and some forms of secondary Not known
asthma, peptic ulceration, urinary-tract obstruction changes with chronic use, vitreous haemorrhage anterior segment
and parkinson's disease and pupillary block
- Adult and children more than 12 years: 4.5 g 8 hourly -
Renal insufficiency: CrCL 20 - 80 ml/minute: 4.5 g 8
Bleeding manifestations, neuromuscular excitability
hourly. CrCL less than 20ml/minute: 4.5 g 12 hourly -
in renal impairment, increased risk of fever and rash Allergic reaction, diarrhoea, nausea and
Piperacillin 4 g & Tazobactam 500 mg Febrile neutropenia, lower respiratory tract infection Neutropenia adult and children more than 12 years, Hypersensitivity to penicillins, cephalosporins or Methotrexate, probenecid, typhoid vaccine,
Tazocin 4.5 g in cystic fibrosis, patients requiring sodium vomiting, headache, injection site reactions,
Injection and severe sepsis more than 50 kg: 4.5 g 6 hourly in combination with beta-lactamase inhibitors vecuronium
restriction. Not to use in children who do not have rash, pruritus, anaphylaxis
aminoglycosides - Children with normal renal function &
neutropenia
less than 50kg: 90 mg/kg 6 hourly in combination with
aminoglycosides
ADULT: 100 - 150 mg/kg IM/IV in divided doses.
Allergic reactions including rashes, fever,
Increase to 200 - 300 mg/kg in severe infections & at
Infants, elderly, renal impairment, chronic heart urticaria, pruritis, anaphylaxis, gastrointestinal Hypersensitivity to piperacillin Methotrexate, probenecid, typhoid vaccine,
Piperacillin Sodium 4 g Injection Pipracil Infections due to Pseudomonas aeruginosa least 16 g in life-threatening infections. Single dose
failure, hypersensitivity to cephalosporins disturbances, glossitis, stomatitis, convulsions, products/penicillins and/or cephalosporins vecuronium
over 2 g: IV route only. Maximum: 24 g/day. CHILD: 50
coagulants& blood disorders, superinfection
mg/kg/dose 6 - 8 hourly
Nervousness, agitation, irritability, anxiety and
Treatment of cerebral functional impairment and 30 - 160 mg/kg/day orally or parenterally 2 times daily Renal insufficiency (possible need for dose Previous hypersensitivity to piracetam.
Piracetam 1 g Injection Nootropil sleep disturbances, fatigue or drowsiness, Warfarin: an increased risk of bleeding
ischaemic stroke or 3 to 4 times daily. Maximum: 24 g/day adjustments), elderly patients with multiple diseases Huntington's chorea
Initially 7.2 g daily in 2 - 3 divided doses, increased
Mild cognitive impairment, post concussional head Nervousness, agitation, irritability, anxiety and
according to response by 4.8 g daily every 3 - 4 days to Renal insufficiency (possible need for dose Previous hypersensitivity to piracetam.
Piracetam 1.2 g Tablet Nootropil syndrome, head injury disorder, chronic vertigo and sleep disturbances, fatigue or drowsiness, Warfarin: an increased risk of bleeding
maximum of 20 g daily. CHILD under 16 years not adjustments), elderly patients with multiple diseases Huntington's chorea
myoclonus gastrointestinal disturbances
recommended
Nervousness, agitation, irritability, anxiety and
Children with learning disability, progressive myoclonic 30 - 160 mg/kg/day orally. To be given 2 times daily or Renal insufficiency (possible need for dose Previous hypersensitivity to piracetam.
Piracetam 20% Solution Nootropil sleep disturbances, fatigue or drowsiness, Warfarin: an increased risk of bleeding
epilepsy and hypoxia 3 - 4 times daily. Maximum 24 g/day adjustments), elderly patients with multiple diseases Huntington's chorea
Drowsiness, confusion, anxiety, dizziness,
delusions, hallucinations, hypotension,
As monotherapy: 150 - 250 mg as 3 - 5 divided doses tachycardia, extrapyramidal effects, dyskinesias,
Hepatic dysfunction, elderly, psychosis, Hypersensitivity to piribedil, cardiogenic shock,
Piribedil 50 mg Tablet Trivastal Retard Parkinson disease daily. As combination with L-dopa therapy: 50 - 150 mg mania, gastric discomfort, nystagmus, changes Dopaminergic antagonists
parkinsonism, mania, thyroid disorder acute phase of myocardial infaction
daily (50 mg per 250 mg of L-dopa) in liver function, gastrointestinal disorders
(nausea, vomiting, flatulence), orthostatic
hypotension, drowsiness
Gastrointestinal disorders, flatulence, insomnia,

pharyngitis, sinusitis, dizziness, vertigo, hearing
i) 20 mg daily, maintenance 10 - 30 mg daily, in single disturbance, photosensitivity, blood disorder, Hypersensitivity, asthma, rhinitis, porphyria,
i) Rheumatoid arthritis, osteoarthritis, ankylosing or divided doses ii) 40 mg daily in single or divided Upper gastrointestinal disease, compromised fluid retention, renal failure, hepatic impairment, angioedema or urticaria induced by other Diuretics, anti-coagulant, sulphonylureas,
Piroxicam 10 mg Capsule Feldene spondylitis ii) Acute musculoskeletal disorders iii) Acute doses for 2 days, then 20 mg daily for 7 - 14 days iii) 40 cardiac function, hypertension, renal disease, Steven-Johnson Syndrome, allergic reactions, NSAIDs, pregnancy (third trimester), lactation, aspirin, captopril, phenytoin, digoxin, highly
gout mg initially, then 40 mg daily in single or divided doses elderly, children less than 12 years chest pain, oedema, hot flushes, flu-like active peptic ulceration, allergy provoked by protein bound drugs
for 4 - 6 days symptoms, swollen eyes, blurred vision, skin aspirin or NSAIDs
rash and pruritus. Gastric side effects are lesser
with this drug as compared to other NSAIDs
Sedation, dizziness, dry mouth and constipation.
Increased appetite, sedation, nausea, fatigue.
Narrow-angle glaucoma, obesity, urinary retention. Rarely, hypersensitivity reactions, face oedema, Central effects of sedatives, hypnotics,
May affect ability to drive and operate machinery. rash, central nervous system stimulation, antihistamines, including certain common cold
ADULT: 0.5 mg in the evening for first 2 days, then 0.5 Pregnancy, breast feeding. Dosage reduction may hallucinations, seizures, depression, drowsiness, preparations and alcohol may be enhanced.
Hypersensitivity to the drug. Children less than 2
Pizotifen 0.5 mg Tablet Sandomigran Prophylactic treatment of vascular headache mg mid-day and evening for next 2 days, then 0.5 mg 3 be necessary in renal impairment, prostatic headache, palpitation, arrhythmias, Antagonised hypotensive effect of adrenergic
years. Postural giddiness
times daily. CHILD: Up to 1.5 mg daily in divided doses hyperplasia, pyloroduodenal obstruction, epilepsy, gastrointestinal disturbance, palpitations, blood neuron blockers. May mask warning signs of
hepatic impairment, elderly, young children. disorders, convulsions, sweating, myalgia, damage caused by ototoxic drugs eg.
Pregnancy, lactation paraesthesias, extrapyramidal effects, sleep aminoglycosides
disturbances, confusion, tinnitus, tremor,
hypotension, hair loss
Primary injection: 1 single injection (0.5 ml) only.
Prevention of pneumococcal infections in high risk Injection site reaction, fever, haemolytic
Booster: Must not be given within 5 years except in Hypersensitivity to pneumococcal vaccine
Pneumococcal Vaccine (Polyvalent) Pneumo 23 subjects from the age of 2 years including patient with a Pregnancy anaemia, thrombocytopenia, anaphylactoid Not known
very high risk patient who received the vaccine while components
history of splenectomy or scheduled splenectomy reaction
under immunosuppressive treatment
Apply 2 - 3 drops carefully to lesion after protecting
surrounding area with vaseline. Wash off after 6 hours Sensitive parts of the body. Caustic to healthy skin. Inflammation of the surrounding skin may occur, Pregnancy, use on bleeding warts, moles,
Podophyllum 10 - 20% Paint - External anogenital warts Not known
or if feel burning sensation and repeat 2 - 3 times Keep away from eyes in which case treatment should be suspended birthmarks and concomitant steroid therapy
weekly or once weekly
Local treatment of cervical and vaginal inflammation
and tissue damage eg. discharge due to bacterial, For cauterization, undiluted once or twice weekly whilst
Occasionally, mild local discomfort at beginning Concomitant use of other topical agents in
Policresulen 360 mg/g Concentrate Albothyl trichomonal and fungal infections, protrusions of for vaginal douches, to be diluted 1 part concentrate to First trimester of pregnancy Not known
of treatment which disappears on discontinuation treating the affected areas
endocervical mucosa (erosion), haemostasis following 5 parts of water
biopsy or excision of uterine polyps
Hypersensitivity to erythromycin and kanamycin.

Vaccine-associated paralysis, fever, Acute or developing infectious diseases.
Polio Oral Vaccine Polioral Immunisation against poliomyelitis 3 doses given orally plus boosters Pregnancy, elderly patients anaphylaxis, Guillain-Barre syndrome, paralytic Leukaemia, lymphoma or generalized Immunosuppressants
poliomyelitis malignancy. Acquired or congenital
immunodeppression. Acute intestinal diseases
Severe renal impairment with oliguria, azotemia Concurrent administration of potassium citrate
Congestive heart failure, hypertension, pulmonary or
The usual dose of potassium citrate is 30 - 60 mEq/day or anuria, Addison's disease, adynamic with potassium- containing medications,
peripheral oedema, toxaemia of pregnancy, monitor
orally in 3 or 4 doses with meals or within 30 minutes Hyperkalaemia, metabolic alkalosis, nausea, episodica hereditaria, acute dehydration, heat angiotensin-converting enzyme inhibitors, or
Polycitra Syrup - For treatment of calcium and uric acid stones serum electrolytes, especially bicarbonate, in
after meals. ADULT: 15 ml 3 times daily well diluted vomiting, diarrhoea cramps, severe myocardial damage, potassium cardiac glycosides, concurrent administration
patients with renal disease, decreased urinary
with water citrate in patients with hyperkalaemia, sodium with aluminum-based gels, blood products
output, especially in the presence of hypocalcaemia
citrate for patients on sodium restriction containing citrate
1 sachet dissolved in 1 L of water. 2-3 L of oral solution Dehydration, severe heart failure, colonic
are required. When morning surgery is planned, the disease causing fragility of the mucosa (active
Bowel cleansing prior to colonoscopy, radiological
Polyethylene Glycol /Macrogol 4000 oral solution is given in the late afternoon the day prior. carcinoma), actual or suspected ileus or Oral medication should not be administered
Fortrans examination or colonic surgery. Suitable for patients Elderly Nausea, vomiting, sensation of fullness
Powder If surgery is scheduled in afternoon, the oral solution intestinal occlusion, gastric retention, bowel within 1 hour of start of therapy
with heart failure or renal failure
should be given on the same day for ingestion to be perforation, severe colitis, children under 15
completed three hours before surgery years
3 drops 3 - 4 times daily. External auditory meatus and
Polymyxin B Sulphate 10,000 U,
Treatment of bacterial infection and inflammation of the canal to be thoroughly cleansed and dried before each Avoid prolong use, perforated eardrum, Hypersensitivity to any of its components, viral Antibacterials eg amphotericin, anticoagulants,
Neomycin Sulphate 5 mg and Otosporin Local sensitivity reactions, ototoxicity
external auditory meatus application but soap should not be used as the hypersensitivity to sulfites ear infection antifungals, antivirals
Hydrocortisone 10 mg Ear Drops
antibiotics may be inactivated by it
Severe renal impairment, cardiac disease, Acute dehydration, heat cramps, hyperkalaemia,
Potassium sparing diuretics, salt substitutes,
By slow IV infusion depending on the deficit or the daily hyperkalaemia. Initial potassium replacement renal failure and in conditions in which potassium
For the correction of severe hypokalaemia and when Nausea, vomiting, gastrointestinal ulceration, ACE inhibitors, angiotensin-II receptor
Potassium Chloride 1 g/10 ml Injection - maintenance requirements. 1 g diluted in 500 ml normal therapy, should not involve glucose infusions, retention is present or where additives of
sufficient potassium cannot be taken by mouth electrocardiogram changes antagonists, methenamine, ciclosporin,
saline or glucose and given slowly over 2 - 3 hours because glucose may cause a further decrease in potassium and chloride could be clinically
tacrolimus
the plasma potassium concentration detrimental
hyperkalaemia. Initial potassium replacement renal failure and in conditions in which potassium
1 g once or twice daily until serum potassium is Nausea, vomiting, gastrointestinal ulceration, ACE inhibitors, angiotensin-II receptor
Potassium Chloride 1 g/15 ml Mixture - Potassium depletion therapy, should not involve glucose infusions, retention is present or where additives of
restored ECG changes antagonists, methenamine, ciclosporin,
because glucose may cause a further decrease in potassium and chloride could be clinically
tacrolimus
hyperkalaemia. Initial potassium replacement renal failure and in conditions in which potassium
For the treatment and specific prevention of ADULT: 2 - 3 tablets daily. Severe deficiency: 9 - 12 Nausea, vomiting, gastrointestinal ulceration, ACE inhibitors, angiotensin-II receptor
Potassium Chloride 600 mg SR Tablet Slow-K therapy, should not involve glucose infusions, retention is present or where additives of
hypokalaemia tablets daily or according to the needs of the patient ECG changes antagonists, methenamine, ciclosporin,
because glucose may cause a further decrease in potassium and chloride could be clinically
tacrolimus
Severe renal impairment with oliguria, azotemia
Congestive heart failure, hypertension, pulmonary or Concurrent administration of potassium citrate
ADULT: 10 ml 3 times daily well diluted with water. or anuria, Addison's disease, adynamic
peripheral oedema, toxaemia of pregnancy, monitor with potassium- containing medications,
Potassium Citrate 3 g/10 ml and Citric CHILD up to 1 year: 2.5 ml 3 times daily; 1 - 5 years: 5 Hyperkalaemia, metabolic alkalosis, nausea, episodica hereditaria, acute dehydration, heat
For systemic or urine alkalinization serum electrolytes especially bicarbonate in patients angiotensin-converting enzyme inhibitors or
Acid Mixture ml 3 times daily; 6 - 12 years: 10 ml 3 times daily. To be vomiting, diarrhoea, mild diuresis cramps, severe myocardial damage, potassium
with renal disease, decreased urinary output, cardiac glycosides, concurrent administration
taken well diluted with water citrate in patients with hyperkalemia, sodium
especially in the presence of hypocalcaemia with aluminum-based gels
citrate for patients on sodium restriction
Renal insufficiency, renal failure,
Diarrhoea, nausea, stomach pain, flatulence, Aluminium and magnesium-containing antacids,
Potassium Dihydrogen Phosphate For treatment of hypophosphataemia or phosphate Renal insufficiency, cardiac disease, metabolic hyperphosphataemia, hypocalcaemia,
- Parenteral nutrition: 10 - 20 mmoles of phosphate daily vomiting, bradycardia, hyperkalaemia, sucralfate, potassium-sparing diuretics, salt
Injection replacement in parenteral nutrition alkalosis hyperkalaemia, hypernatraemia, Addison's
weakness, dyspnoea substitutes, ACE inhibitors, digitalis
disease
Prolonged use can lead to hypothyroidism, cystic Concurrent use with ACE inhibitors may lead to
Hypersensitivity to iodine or any component of
fibrosis patients have an exaggerated response, can Metallic taste, irregular heart beat, confusion, hyperkalaemia, cardiac arrhythmias or cardiac
the formulation; hyperkalaemia; pulmonary
Pre-operative management of hyperthyroidism and cause acne flare-ups, can cause dermatitis, use with tiredness, fever, skin rash, goiter, salivary gland arrest. Concurrent use with diuretics or
Potassium Iodide Mixture - ADULT and CHILD: 50 - 250 mg 3 times daily oedema; impaired renal function;
thyrotoxicosis caution in patients with a history of thyroid disease, swelling/tenderness, thyroid adenoma, swelling potassium-sparing diuretic may lead to
hyperthyroidism; iodine-induced goiter;
Addison's disease, cardiac disease, myotonia of neck/throat, myxedema hyperkalaemia, cardiac arrhythmias or cardiac
pregnancy
congenita, tuberculosis, acute bronchitis arrest. Lithium may cause additive hypothyroid
Potassium Permanganate 1:10,000 Cleansing and deodorising suppurative eczematous As soaks or wet dressing 1 - 3 times daily or as Avoid contact with eyes and other mucous
- Irritant to tissues and stain skin brown Hypersensitivity to any component Not known
Solution reactions and wounds required membranes
Potassium Permanganate 1:20,000 Cleansing and deodorising suppurative eczematous Avoid contact with eyes and other mucous
- As a bath once to twice daily or as required Irritant to tissues and stain skin brown Hypersensitivity to any component Not known
Solution reactions and wounds membranes
Skin operation prior to surgery, in cleansing open Highly toxic if ingested, sodium thiosulfate is the
Povidone Iodine 10% (equivalent to Hypersensitivity to iodine or any component of
- wounds, as an antiseptic for operative wounds Paint the area once or twice daily and allow to dry most effective chemical antidote, avoid contact with Rash, pruritus, local oedema Not known
1% iodine) Solution the formulation
infections eyes, use with caution in infants and nursing women
Spread 5 ml over both hands and rub thoroughly for
about 5 minutes. Rinse thoroughly. Repeat if desired. Highly toxic if ingested, sodium thiosulfate is the
Povidone Iodine 7.5% (equivalent to Hypersensitivity to iodine or any component of
- As preoperative scrub for hands and skin Pre-operative use on patient: Apply scrub and rub most effective chemical antidote, avoid contact with Rash, pruritus, local oedema Not known
0.75% iodine) Scrub the formulation
thoroughly for about 5 minutes. Rinse off using a sterile eyes, use with caution in infants and nursing women
gauze saturated with water
1 - 2 g by IV infusion in 100 ml saline over 15 - 30 Myasthenia gravis, renal dysfunction, slow IV

Antidote in the treatment of organophosphorus minutes or slow IV injection over 10 minutes as 5 % infusion may prevent tachycardia, laryngospasm and Hypersensitivity to pralidoxime,
Nausea, vomiting, dizziness, headache, blurred
insecticide poisoning and in the control of overdosage solution. In water, followed after 1 hour by a second muscle rigidity. Not effective in poisonings due to phosphorus/inorganic phosphate poisoning,
Pralidoxime 0.5 g/20 ml Injection Protopam vision, bitter after taste, hyperventilation, Not known
by anticholinergic drugs used in the treatment of dose of 1 - 2 g. CHILD : 20 - 40 mg /kg body weight, organophosphates without anticholinesterase organophosphates without anticholinesterase
laryngeal spasm
myasthenia gravis may be given depending on the severity and response activity, not effective in poisonings due to activity
to treatment phosphorus/inorganic phosphates, renal impairment
Dose escalation: 0.125 mg 3 times daily on week 1 then
0.25 mg 3 times daily week 2 then 0.5 mg 3 times daily
on week 3. Increase by 0.75 mg at weekly intervals if
Nausea, constipation, somnolence, hallucination,
Treatment for signs and symptoms of advanced needed up to maximum of 4.5 mg/day. Patient on Renal impairment, severe cardiovascular disease. Cimetidine, amantadine, antipsychotics (typical),
Pramipexole Dihydrochloride 0.125 confusion, dizziness, dyskinesia, amnesia, Hypersensitivity to pramipexole or to any of the
Sifrol idiopathic Parkinson's disease. It may be used as levodopa: Reduced dose. Renal impairment: creatinine Avoid abrupt withdrawal. Pregnancy and lactation. central nervous system depressants. Avoid
mg Tablet asthenia, dream disorder, extrapyramidal excipients
monotherapy or in combination with levodopa clearance: 20 - 50 ml/minute: initially 0.125 mg twice May impair ability to drive or operate machinery alcohol
movements, insomnia, orthostatic hypotension
daily, creatinine clearance less than 20 ml/minute
initially 0.25 mg daily as a single dose, maximum dose:
1.5 mg twice daily
Dose escalation: 0.125 mg 3 times daily on week 1 then
0.25 mg 3 times daily week 2 then 0.5 mg 3 times daily
on week 3. Increase by 0.75 mg at weekly intervals if
Nausea, constipation, somnolence, hallucination,
Treatment for signs and symptoms of advanced needed up to maximum of 4.5 mg/day. Patient on Renal impairment, Severe cardiovascular disease. Cimetidine, amantadine, antipsychotics (typical),
Pramipexole Dihydrochloride 1 mg confusion, dizziness, dyskinesia, amnesia, Hypersensitivity to pramipexole or to any of the
Sifrol idiopathic Parkinson's disease. It may be used as levodopa: Reduced dose. Renal impairment: creatinine Avoid abrupt withdrawal. Pregnancy and lactation. central nervous system depressants. Avoid
Tablet asthenia, dream disorder, extrapyramidal excipients
monotherapy or in combination with levodopa clearance: 20 - 50 ml/minute: initially 0.125 mg twice May impair ability to drive or operate machinery alcohol
movements, insomnia, orthostatic hypotension
daily, creatinine clearance less than 20 ml/minute
initially 0.25 mg daily as a single dose, maximum dose:
1.5 mg twice daily
persistent. May cause myopathy and renal failure Cholestyramine, ciprofibrate, colestipol,
Hypercholesterolaemia and coronary heart disease Rash, myalgia, headache, non-cardiac chest Hypersensitivity to pravastatin, liver disease,
Pravastatin Sodium 20 mg Tablet Pravachol 10 - 20 mg once daily. Maximum: 40 mg daily due to rhabdomyolysis. Concomitant administration cyclosporin, erythromycin, fenofibrate,
intolerant or not responsive to other forms of therapy pain, nausea, vomiting, diarrhoea, fatigue pregnancy or lactation
of fibrates, nicotinic acid, immunosuppressives gemfibrozil, niacin
including cyclosporin, macrolide antibiotics
(erythromycin, clarithromycin), itraconazole and
ketoconazole, may increase the risk of myopathy
Initially 0.5 mg 2 - 3 times daily, the initial dose on
Dizziness, lightheadedness, orthostatic hypotension, Dizziness, orthostatic hypotension, oedema,
retiring to bed at night; increased to 1 mg 2 - 3 times Hypersensitivity to prazosin products or other Additive hypotensive effect with diuretics or other
Prazosin HCl 1 mg Tablet Minipress Hypertension syncope, fainting and sudden loss of consciousness palpitations, urinary incontinence, dyspnoea,
daily after 3 - 7 days: further increased if necessary to quinazolines antihypertensives
due to first-dose effect priapism, headache, lack of energy, nausea
maximum 20 mg daily
maximum 20 mg daily
maximum 20 mg daily
of Levodopa (should not be administered
Pre/Post Natal Vitamin & Mineral Vitamin and mineral supplement for use during
- 1 capsule daily or based on individual requirements Severe renal or liver failure Hypervitaminosis Hypersensitivity to product components concurrently), vitamin B6 reduces the plasma
Capsule pregnancy and lactation

Pre/Post Natal Vitamin & Mineral Vitamin and mineral supplement for use during
- 1 tablet daily or based on individual requirements Severe renal or liver failure Hypervitaminosis Hypersensitivity to product components concurrently), vitamin B6 reduces the plasma
Tablet pregnancy and lactation
Phenytoin, phenobarbital, rifampin increase
clearance of methylprednisolone. Potassium
i) 5 - 25 mg daily in divided doses ii) 10 - 20 mg/m2
i) Replacement therapy for primary and secondary Fluid and electrolyte disturbances, muscle depleting diuretics enhance potassium depletion.
body surface daily in divided doses iii) ADULT: 5 - 60 Discontinue treatment by reducing the dosage
Prednisolone 3 mg/5 ml Syrup Prednisone adrenocortical insufficiency ii) Adrenogenital syndrome weakness and peptic ulcer, osteoporosis, Hypersensitivity and systemic fungal infection Skin test antigens and immunizations decrease
mg daily. CHILD: 0.5 - 2 mg/kg/day in divided doses gradually
iii) Other therapy abdominal distention, nausea and vomiting response. Increase circulating glucose level and
every 6 - 8 hours or as a single daily
may need adjustment of insulin or oral
hypoglycaemics
Phenytoin, phenobarbital, rifampin increase
clearance of methylprednisolone. Potassium
i) 5 - 25 mg daily in divided doses ii) 10 - 20 mg/m2
i) Replacement therapy for primary and secondary Fluid and electrolyte disturbances, muscle depleting diuretics enhance potassium depletion.
body surface daily in divided doses iii) ADULT: 5 - 60 Discontinue treatment by reducing the dosage
Prednisolone 5 mg Tablet Prednisone adrenocortical insufficiency ii) Adrenogenital syndrome weakness and peptic ulcer, osteoporosis, Hypersensitivity and systemic fungal infection Skin test antigens and immunizations decrease
mg daily. CHILD: 0.5 - 2 mg/kg/day in divided doses gradually
iii) Other therapy abdominal distention, nausea and vomiting response. Increase circulating glucose level and
every 6 - 8 hours or as a single daily
may need adjustment of insulin or oral
hypoglycaemics
Hereditary problems of galactose intolerance, Lapp
Somnolence, euphoric mood, confusion,
i) Initially, 75 mg twice daily. May be increased to 150 lactase deficiency or glucose-galactose
decreased libido, irritability, ataxia, abnormal
mg twice daily after 3-7 days. Max: 600 mg/day after an malabsorption, avoid abrupt withdrawal, renal
i) Second line treatment of neuropathic pain in patients coordination, tremor, dysarthria, paraesthesia, Hypersensitivity to pregabalin or any other CNS depressants (eg, alcohol, lorazepam,
Pregabalin 150 mg Capsules Lyrica additional 7-day interval ii) Initially, 75 mg twice daily. impairment, diabetes, chronic heart failure,
who do not response to first line drugs ii) Fibromyalgia blurred vision, diplopia, vertigo, vomiting, erectile component of the product, breast-feeding oxycodone)
May be increased to 150 mg twice daily within 1 week pregnancy & lactation, children less than 17 years,
dysfunction, peripheral oedema, angioedema,
or 225 mg twice daily. Max: 450 mg/day elderly patients. Potential for an increase in risk of
abnormal gait, increased weight
Hereditary problems of galactose intolerance, Lapp
Somnolence, euphoric mood, confusion,
i) Initially, 75 mg twice daily. May be increased to 150 lactase deficiency or glucose-galactose
decreased libido, irritability, ataxia, abnormal
mg twice daily after 3-7 days. Max: 600 mg/day after an malabsorption, avoid abrupt withdrawal, renal
i) Second line treatment of neuropathic pain in patients coordination, tremor, dysarthria, paraesthesia, Hypersensitivity to pregabalin or any other CNS depressants (eg, alcohol, lorazepam,
Pregabalin 75 mg Capsule Lyrica additional 7-day interval ii) Initially, 75 mg twice daily. impairment, diabetes, chronic heart failure,
who do not response to first line drugs ii) Fibromyalgia blurred vision, diplopia, vertigo, vomiting, erectile component of the product, breast-feeding oxycodone)
May be increased to 150 mg twice daily within 1 week pregnancy & lactation, children less than 17 years,
dysfunction, peripheral oedema, angioedema,
or 225 mg twice daily. Max: 450 mg/day elderly patients. Potential for an increase in risk of
abnormal gait, increased weight
Methaemoglobinaemia may occur in high doses and
renal impairment. Anaemia; cardiac or ventilatory
failure; hypoxia; lactation. Rate of injection shoud not
be too rapid. Avoid inadvertent intravascular Confusion, respiratory depression, hypotension
injection. Avoid prolonged use. Elderly; child; and bradycardia, hypersensitivity, Cisatracurium and hyaluronidase. Sulfonamides,
debilitated; epilepsy; impaired respiratory function or methaemoglobinaemia, myocardial depression, antimalarials, certain nitric compounds may
Adjust dose according to the site of operation and Hypovolumia and complete heart block.
Prilocaine 0.5% Plain Injection (5 cardiac conduction; shock; hepatic impairment; seizures, cyanosis, restlessness, excitement, potentiate methaemoglobinaemia. Additive toxic
Citanest Only for IV regional anaesthesia or Bier's Block response of patient: To a maximum of 400 mg or 6 Congenital or idiopathic methaemoglobinaemia,
mg/ml) epidural or spinal block should not be employed to nervousness, paraesthesias, dizziness, tinnitus, effects with agents structurally related to local
mg/kg porphyria, pregnancy
patients with cerebrospinal diseases; cardiogenic or blurred vision, nausea, vomiting, muscle anaesthetics. Precipitation can occur with
hypovolemic shock; altered coagulation status, twitching, tremors, convulsions, arrhythmias, alkaline solutions
pyogenic infection of the skin at or near the injection cardiac arrest
site. Do not inject into or apply to inflamed or infected
tissues or damaged skin or mucosa. Do not instill
into the middle ear
Use with caution in patients with a deficiency in
G6PD (may cause acute haemolytic anaemia) and Concomitant medications which cause bone
i) ADULT: 15 mg daily for 14 days. CHILD: 0.3 mg/kg
i) Treatment of malaria ii) Prophylaxis together with a patients with a nicotinamide-adenine dinucleotide Anaemia, leucocytosis, abdominal pain, marrow suppression, rheumatoid arthritis, lupus
Primaquine 7.5 mg base Tablet - body weight daily for 14 days ii) ADULT: 30 mg once Artemether/ lumefantrine
schizonticide such as chloroquine hydroxide (NADH) methaemoglobin-reductase methaemoglobinaemia erythematosus, glucose-6-phosphate
weekly. CHILD: 0.5 mg once weekly
deficiency (at risk of developing dehydrogenase (G6PD) deficiency, pregnancy
methaemoglobinaemia and cyanosis)
Enhances effects of other central nervous
Dizziness, somnolence, nausea, vomiting,
system depressants. Reduces efficacy of other
ADULT: Initially 1 tablet daily in the evening, increasing musculoskeletal problems, ataxia, visual
Hypersensitivity to primidone products, anticonvulsants, oral anticoagulants, oral
by 1 tablet every 4 - 7 days to 3 - 4 tablets daily. Avoid acute withdrawal (may precipitate status disturbances and rashes. Fatigue, drowsiness
Primidone 250 mg Tablet Mysoline Epilepsy phenorbarbitone and porphyria. Pregnancy and contraceptives, induces hepatic metabolism of
Maximum dosage: 1.5 g daily in divided doses. CHILD: epilepticus), pregnancy, lactation and haemodialysis and dizziness. Hypersensitivity, rash,
lactation many drugs, reduces efficacy of beta-blockers,
6 - 8 years: Up to 1/2 adult dose haematologic disturbances, drowsiness,
chloramphenicol, cimetidine, corticosteroids,
nystagmus
furosemide
Amoxicillin, aspirin, ertapenem, ketorolac,
Aplastic anaemia, disease of hematopoietic lorazepam, methotrexate, sodium thiosalicylate,
system, leukopenia, neutropenia, History of blood disorders, nephrolithiasis, zidovudine. Pyrazinamide and salicylates
Peptic ulcer disease, renal impairment - CrCl less thrombocytopenic disorder, hepatic necrosis, porphyria, acute gout attack, children under 2 antagonize uricosuric effects of probenecid.
Hyperuricemia associated with gout and gouty arthritis
than 50 mL/minute. Pregnancy and lactation; renal gout, acute nephrotic syndrome, rash, headache, years of age, co-administration of salicylates, Uricosuric effects of probenecid inhibited by loop
Probenecid 500 mg Tablet (for cases allergic to allopurinol or serum uric acid not 500 mg to 1000 mg twice daily
impairment, history of peptic ulcer, G6PD deficient nausea, seizures (overdosage), anorexia, uric acid kidney stones, renal impairment, G6PD- diuretics and thiazides; natriuresis by loop
controlled by allopurinol alone)
individuals vomiting, urinary frequency, sore gums, deficiency, hypersensitivity to probenecid, acute diuretics is opposed by probenecid while
dizziness, dermatitis, uric acid nephrolithiasis gout attack, blood dyscrasias natriuresis by thiazides is either unopposed or
and pruritus enhanced. It prolongs the duration of action of
beta-lactam antibiotics
Hypersensitivity reactions, especially skin
rashes, diarrhoea, nausea, anaphylaxis,
History of penicillin or cephalosporin.
haemolytic anaemia and neutropenia, History of anaphylactic, accelerated allergic (eg, Probenecid, bacteriostatic antibacterials such as
ADULT: 300,000 - 900,000 units (300 - 900 mg) IM Hypersensitivity reactions. Histories of significant
Procaine Benzylpenicillin Aqueous 3 Treatment of infections due to Penicillin G-sensitive prolongation of bleeding time and defective hives) or serum sickness reactions to previous chloramphenicol and tetracyclines,
- daily. CHILD: Up to 1 year: 150 mg IM daily. 1 - 5 years: allergies and or asthma. Inadvertent intra-arterial
mega units (3 g) Injection organisms platelet function, convulsions and other signs of penicillin administration. Hypersensitivity to anticoagulants, methotrexate and oral
300 mg IM daily. 6 - 12 years: 600 mg IM daily administration or injection into or near major
CNS toxicity (encephalopathy has followed procaine contraceptives
peripheral nerves or blood vessels
intrathecal administration and can be fatal) and
electrolyte disturbances
Hypersensitivity reactions, especially skin
rashes, diarrhoea, nausea, anaphylaxis,
History of penicillin or cephalosporin.
haemolytic anaemia and neutropenia, History of anaphylactic, accelerated allergic (eg, Probenecid, bacteriostatic antibacterials such as
ADULT: 300,000 - 900,000 units (300 - 900 mg) IM Hypersensitivity reactions. Histories of significant
Procaine Benzylpenicillin Aqueous 4 Treatment of infections due to Penicillin G-sensitive prolongation of bleeding time and defective hives) or serum sickness reactions to previous chloramphenicol and tetracyclines,
- daily. CHILD: Up to 1 year: 150 mg IM daily. 1 - 5 years: allergies and or asthma. Inadvertent intra-arterial
mega units (4 g) Injection organisms platelet function, convulsions and other signs of penicillin administration. Hypersensitivity to anticoagulants, methotrexate and oral
300 mg IM daily. 6 - 12 years: 600 mg IM daily administration or injection into or near major
CNS toxicity (encephalopathy has followed procaine contraceptives
peripheral nerves or blood vessels
intrathecal administration and can be fatal) and
electrolyte disturbances
Severe renal/ hepatic impairment. Intake of alcohol
or tyramine containing foods may cause disulfiram-
like reaction. Concomitant central nervous system
Pethidine, amitriptyline, dothiepin, neurotoxicity,
repressants may result in central nervous system Myelosuppression, hypertension, headache,
carbamazepine, pseudoephedrine, ephedrine,
depression. Concomitant chemotherapy or radiation, nausea, vomiting, hypersensitivity reaction, flu-
100 mg/m2 (maximum 150 mg) orally on Days 1 to 14, levodopa, live vaccines, rotavirus vaccine,
wait one month or longer before giving procarbazine. like syndrome, paraesthesias, neuropathies, Hypersensitivity to procarbazine. Pregnancy,
in combination with other cytotoxic drugs. CHILD: 100 fluoxetine, sertraline, venlafaxine, methotrexate,
Procarbazine HCl 50 mg Capsule Natulan Lymphomas Discontinue promptly if any of the following occur, confusion, interstitial pneumonitis, second lactation, inadequate bone marrow reserve,
mg/m2 per day for one week every 4 weeks (Check ethanol, hypertension, headache, increased risk
diarrhoea, central nervous system effects, malignancy, amenorrhoea, azoospermia, severe hepatic and renal impairment
with protocol) of infection by the live vaccine. Central nervous
leucopenia, thrombocytopenia, stomatitis, bleeding infertility, bone marrow depression, ataxia,
system toxicity or serotonin syndrome. Tyramine
or hypersensitivity reaction. Concurrent use with tachycardia
foods increase blood pressure
tricyclic antidepressant may give rise to central
nervous system excitation. Renal impairment,
hepatic dysfunction
Hypotension, pregnancy and lactation, glaucoma, Tramadol, increased risk of seizures.
i) Injection IM 12.5 mg stat and repeated if necessary
prostatic hypertrophy, stenosing peptic ulcer, Procyclidine, decreased phenothiazine serum
after 6 hours or orally 20 mg stat followed by 10 mg
children with acute illnesses, dehydration or Extrapyramidal symptoms, drowsiness, postural concentrations, decreased phenothiazine
after 2 hours. Prevention: 5 - 10 mg 2 - 3 times a day. CNS depression or coma, bone marrow
electrolyte imbalance, signs and symptoms hypotension, coma, neuroleptic malignant effectiveness, enhanced anticholinergic effects
i) Severe nausea and vomiting ii) Vertigo/labyrinthine CHILD (over 10 kg only) 250 mcg/kg 2 - 3 times a day depression, phaeochromocytoma,
Prochlorperazine Maleate 5mg Tablet Stemetil suggestive of Reye's syndrome in children and syndrome, cholestatic jaundice, leucopenia and (ileus, hyperpyrexia, sedation, dry mouth).
disorders ii) For labyrinthine disorders 5 mg 3 times daily, hypersensitivity to phenothiazines, comatose
adolescents, patients with tardive dyskinesia or a agranulocytosis, constipation, dry mouth, urinary Levodopa, loss of levodopa efficacy. Ethanol,
gradually increased to 30 mg daily in divided doses, states, cardiovascular collapse
history of neuroleptic malignant syndrome, epilepsy, retention, liver damage and insomnia increased central nervous system depression
then reduced after several weeks to 5 - 10mg daily. Not
acute narrow angle glaucoma, liver damage, and an increased risk of extrapyramidal
recommended in children
insomnia reactions
Hypotension, pregnancy and lactation, glaucoma, Tramadol, increased risk of seizures.
prostatic hypertrophy, stenosing peptic ulcer, Procyclidine, decreased phenothiazine serum
children with acute illnesses, dehydration or Extrapyramidal symptoms, drowsiness, postural concentrations, decreased phenothiazine
CNS depression or coma, bone marrow
Deep IM injection, 12.5 mg repeated if necessary after electrolyte imbalance, signs and symptoms hypotension, coma, neuroleptic malignant effectiveness, enhanced anticholinergic effects
Prochlorperazine Mesylate 12.5 i) Severe nausea and vomiting ii) Vertigo/labyrinthine depression, phaeochromocytoma,
Stemetil 6 hours and then followed by an oral dose. Not suggestive of Reye's syndrome in children and syndrome, cholestatic jaundice, leucopenia and (ileus, hyperpyrexia, sedation, dry mouth).
mg/ml Injection disorders hypersensitivity to phenothiazines, comatose
recommended in children adolescents, patients with tardive dyskinesia or a agranulocytosis, constipation, dry mouth, urinary Levodopa, loss of levodopa efficacy. Ethanol,
states, cardiovascular collapse
history of neuroleptic malignant syndrome, epilepsy, retention, liver damage and insomnia increased central nervous system depression
acute narrow angle glaucoma, liver damage, and an increased risk of extrapyramidal
insomnia reactions
i) All forms of Parkinson's disease (idiopathic paralysis Closed-angle glaucoma, narrow-angle Anticholinergic-like drugs, chlorpromazine,
Hypotension, severe psychoses, prostatic
agitants), post-encephalitis and arteriosclerosis ii) To By IM injection 5 - 10 mg repeated if necessary after 20 Excitability, dizziness, hallucinations (seen on glaucoma, hypersensitivity to procyclidine haloperidol, promethazine, thioridazine,
hypertrophy, tachycardia, urinary retention, hepatic
Procyclidine HCl 10 mg/2 ml Injection Kemadrin control troublesome extrapyramidal symptoms induced minutes. Maximum 20 mg daily. By IV injection 5 - 10 abuse), dry mouth, constipation, urinary products, gastrointestinal tract or urinary outflow trifluoperazine and prochlorperazine. Reduced
or rena impairment, lactation, pregnancy, children,
by neuroleptic drugs including pseudo-parkinsonism, mg retention, agitation, restlessness, convulsions obstruction, prostatic hypertrophy, tardive peristaltic movement affects absorption of
elderly
acute dystonic reactions and akathisia dyskinesia in patients on neuroleptic drugs erythromycin, penicillin
Constipation, dizziness, headache, mood

swings, cerebrovascular accident,
cerebrovascular disease, myocardial infarction,
thrombosis of retinal artery, venous
Severe hepatic impairment. Discontinue use if
thromboembolism, dementia, ectopic pregnancy, Undiagnosed vaginal bleeding, breast or genital
thrombophlebitis, cerebrovascular disorders,
90 mg intravaginally daily from day of egg retrieval till pulmonary embolism, gastrointestinal organ malignancy, acute porphyria, Should not be used concurrently with other local
Progesterone 8% Vaginal Gel Crinone Treatment of infertility due to inadequate luteal phase pulmonary embolism and retinal thrombosis occur.
pregnancy established disturbances, joint pain, decreased libido, thrombophlebitis, thromboembolic disorder, intravaginal therapy
History of psychic depression, diabetic patients. May
nervousness, breast tenderness and pain, cerebral apoplexy, missed abortion, lactation
affect ability to drive or operate machinery
dyspareunia, nocturia, allergy, cramps, fatigue,
pain, genital moniliasis and pruritus, aggressive
reaction, vaginal dryness, cystitis, urinary tract
infection, vaginal discharge
Oedema and inflammation in conjunction with other
Prolase Tablet Papase 2 tablet 4 times daily Renal or hepatic dysfunction and pregnancy Skin rash, vertigo and gastrointesinal upsets Blood clotting disease No known
physical or chemotherapeutic measures
By deep IM: ADULT: 25 - 50 mg, maximum 100 mg. Pregnancy, lactation, cardiovascular or hepatic Sedation, gastrointestinal disturbances,
Hypersensitivity to promethazine. Comatose Antihypertensives, phenothiazines, alcohol,
CHILD: 5 - 10 years : 6.25 - 12.5 mg. By slow IV: 25 - diseases, narrow angle glaucoma, asthma, COPD, antimuscarinic effects, muscular weakness,
Promethazine HCl 25 mg/ml Injection Phenergan Allergic conditions patients, acute attack of asthma, children under anticholinergics, tricyclic antidepressants,
50 mg in a solution of 2.5 mg/ml in water for injection. pediatric patient, peptic ulcer, pyloduodenal tinnitus, allergic reactions, blood disorders,
2 years, SC and intra- or peri-arterial injection MAOIs, evening primrose oil
Maximum 100 mg obstruction, prostatic hypertrophy respiratory depression
Pregnancy, lactation, cardiovascular or hepatic Sedation, gastrointestinal disturbances,
Hypersensitivity to promethazine. Comatose Antihypertensives, phenothiazines, alcohol,
CHILD 2 - 5 years: 5 - 15 mg daily, 5 - 10 years : 10 - diseases, narrow angle glaucoma, asthma, COPD, antimuscarinic effects, muscular weakness,
Promethazine HCl 5 mg/5 ml Syrup Phenergan Allergic conditions patients, acute attack of asthma, children under anticholinergics, tricyclic antidepressants,
25 mg daily paediatric patient, peptic ulcer, pyloduodenal tinnitus, allergic reactions, blood disorders,
2 years MAOIs, evening primrose oil
obstruction, prostatic hypertrophy respiratory depression
Down's Syndrome, children and in elderly patients, Hypersensitivity to propantheline or other
autonomic neuropathy, congestive heart failure, anticholinergic drugs, myasthenia gravis, narrow- Loss of cisapride efficacy, increased serum
15 mg 3 times daily at least 1 hour before meals and 30
Symptomatic relief of gastrointestinal disorders acute myocardial infarction, hypertension, Xerostomia, paralytic ileus, constipation, angle glaucoma, obstructive gastrointestinal digoxin levels, procainamide coadministered with
Propantheline Bromide 15 mg Tablet Probanthine mg at night, maximum 120 mg daily. CHILD not
characterised by smooth muscle spasm hyperthyroidism, reflux oesophagitis, diarrhoea, heartburn, bloating and reduced salivation disease, obstructive uropathy, paralytic ileus or propantheline may result in additive antivagal
recommended
ulcerative colitis, prostatic hypertrophy, intestinal atony, reflux oesophagitis, ulcerative effects on atrioventricular nodal conduction
tachyarrhythmia colitis or toxic megacolon
Deep anaesthesia, 1 drop in each eye every 5 to 10

Use cautiously in patients with cardiac disease and Transient stinging and burning, conjunctival
minutes for 5 to 7 doses. Superficial anaesthesia, 1 to 2
Proparacaine HCI 0.5% Ophthalmic hyperthyroidism, prolonged use not recommended. redness, keratitis, systemic toxicity. Long term Hyaluronidase, St John's wort, increase effects
Alcaine Topical anaesthesia in ophthalmic procedures drops in each eye before surgery or diagnostic Hypersensitivity
Drops Protect the eye from irritants, rubbing and foreign use may result in corneal damage, loss of vision of phenylephedrine, tropicamide
procedure. Tonometry and/or tonography procedure, 1
bodies during period of anaesthesia and retard healing
to 2 drops in each eye before procedure
Enhanced antimuscarinic effects when used with
antimuscarinic drugs e.g. amantadine,
Dry mouth, constipation, blurred vision,
phenothiazine psychotics, tricyclic
Elderly, autonomic neuropathy, susceptibility to drowsiness, nausea, vomiting, abdominal
Myasthenia gravis, glaucoma, significant bladder antideppressant , tranqulisers, anticholinergics
angle-closure glaucoma, hiatus hernia with reflux discomfort, micturition difficulty, angioedema,
outflow obstruction, urinary retention, severe and b-sympathomimetics, antiarrhythmic
Treatment of urinary incontinence, urgency and ADULT: 15 mg twice daily to 3 times daily, increase to 4 oesophagitis, hepatic or renal impairment. May arrhythmias, tachycardia, palpitations, skin
ulcerative colitis, toxic megacolon, disopyramide. Decreased effects due to
frequency in neurogenic detrusor overactivity (detrusor times daily if required. Max dose: 60 mg daily. CHILD worsen hyperthyroidism, coronary artery disease, reactions, headache, diarrhoea, hypotension,
Propiverine HCl 15 mg Tablet Mictonorm gastrointestinal obstruction or intestinal atony, concomitant medication with cholinergic drugs.
hyperreflexia) and in idiopathic detrusor overactivity more than 5 years: 0.2 to 0.4 mg/kg per day in 2 divided chronic heart failure, hypertension, prostatic drowsiness, central nervous system stimulation,
pregnancy, lactation, hepatic disorders, severe Reduced blood pressure in patients treated with
(overactive bladder) doses hyperplasia, arrhythmias, tachycardia. Monitor liver fatigue, reduce sweating, leading to heat
renal impairment, prostatic hypertrophy, isoniazid. Reduced gastric motility may reduce
enzyme values in long-term therapy. Patients with sensations and fainting in hot environments or in
tachyarrhythmias the absorption of certain drugs. May antagonise
diarrhoea or fever patients with fever, very rarely may precipitate
the gastrointestinal effects of prokinetics (e.g.
angle-closure glaucoma
cisapride, domperidone and metoclopramide),
sedative drugs may enhance drowsiness
Monitor blood lipid concentration in patients at risk
for fat overload, risk of convulsion in epileptic
patients, monitor signs of hypotension, airway
obstruction and oxygen desaturation. Cardiac,
respiratory, renal or hepatic impairment;
hypovolaemic or debilitated patients; disorders of fat
metabolism or conditions where lipid emulsions
Bupivacaine, lidocaine, succinylcholine. Diprivan
should be used cautiously. Do not use in pregnancy,
Very common: Local pain on induction. has been used in association with spinal and
do not use for obstetric anaesthesia. Avoid in
Common: Hypotension, bradycardia, transient epidural anaesthesia and with commonly used
lactation, has been used for termination in 1 st
apnoea during induction, nausea & vomiting & premedicants, neuromuscular-blocking drugs,
trimester. Ability to drive or operate machinery may
headache during recovery phase, withdrawal inhalational agents and analgesic agents; no
be affected. Bradycardia. Contains EDTA which
symptoms in children, flushing in children. pharmacological incompatibility has been
Induction: 1.5-2.5mg/ kg at the rate of 20-40 mg every chelates metal ions, including zinc. Hence, consider
Uncommon: Thrombosis & phlebitis. Rare: encountered. Lower doses of Diprivan may be
10 seconds. CHILD more than 8 years: usually 2.5mg/ need for supplemental zinc during prolonged
Epileptiform movements, including convulsions & required where general anaesthesia is used as
Induction & maintenance of general anaesthesia. kg. Maintenance: IV 25-50 mg repeated according administration especially in patients predisposed to Children less than 3 years and obstetric
Propofol 1 % Injection Diprivan opisthotonus during induction, maintenance & an adjunct to regional anaesthetic techniques.
Sedation of ventilated ICU patients response. IV infusion: 4-12mg/kg/hour; CHILD more zinc deficiency eg. patients with burns, diarrhoea, anaesthesia
recovery. Very rare: Rhabdomyolysis, Incompatibilities: Diprivan should not be mixed
than 3 years: 9-15 mg/kg/ hour. Sedation: 0.3 - 4 major sepsis. Contains no antimicrobial
pancreatitis, post-operative fever, discoloration prior to administration with injections or infusion
mg/kg/hour up to 3 days preservatives. When aspirated, must be drawn
of urine following prolonged administration, fluids other than with 5% Dextrose in PVC bags
aseptically into sterile syringe or giving set
anaphylaxis - may include angioedema, or glass infusion bottles or lignocaine injection or
immediately after opening ampoule or breaking vial
bronchospasm, erythema & hypotension - sexual alfentanil injection in plastic syringes. The
seal. Administration must commence with or without
disinhibition, pulmonary oedema, post-operative neuromuscular-blocking agents, atracurium and
delay. Asepsis must be maintained for Diprivan &
unconsciousness mivacurium should not be given the same IV line
infusion instrument throughout infusion period. Any
as Diprivan without prior flushing
fluids added to Diprivan line must be administered
close to cannula site. Diprivan must not be
administered via microbiological filter. Single infusion
must not exceed 12 hour. At the end of the
procedure or at 12 hours, whichever is sooner, both
reservoir & infusion line must be discarded &
replaced as appropriate
Monitor blood lipid concentration in patients at risk
for fat overload, risk of convulsion in epileptic
patients, monitor signs of hypotension, airway
obstruction and oxygen desaturation. Cardiac,
respiratory, renal or hepatic impairment;
hypovolaemic or debilitated patients; disorders of fat
metabolism or conditions where lipid emulsions
Bupivacaine, lidocaine, succinylcholine. Diprivan
should be used cautiously. Do not use in pregnancy,
Very common: Local pain on induction. has been used in association with spinal and
do not use for obstetric anaesthesia. Avoid in
Common: Hypotension, bradycardia, transient epidural anaesthesia and with commonly used
lactation, has been used for termination in 1st
apnoea during induction, nausea & vomiting & premedicants, neuromuscular-blocking drugs,
trimester. Ability to drive or operate machinery may
headache during recovery phase, withdrawal inhalational agents and analgesic agents; no
be affected. Bradycardia. Contains EDTA which
symptoms in children, flushing in children. pharmacological incompatibility has been
Induction: 1.5-2.5mg/ kg at the rate of 20-40 mg every chelates metal ions, including zinc. Hence, consider
Uncommon: Thrombosis & phlebitis. Rare: encountered. Lower doses of Diprivan may be
10 seconds. CHILD more than 8 years: usually 2.5mg/ need for supplemental zinc during prolonged
Epileptiform movements, including convulsions & required where general anaesthesia is used as
Induction & maintenance of general anaesthesia. kg. Maintenance: IV 25-50 mg repeated according administration especially in patients predisposed to Children less than 3 years and obstetric
Propofol 1% Prefilled Syringes Diprivan opisthotonus during induction, maintenance & an adjunct to regional anaesthetic techniques.
Sedation of ventilated ICU patients response. IV infusion: 4-12mg/kg/hour; CHILD more zinc deficiency eg. patients with burns, diarrhoea, anaesthesia
recovery. Very rare: Rhabdomyolysis, Incompatibilities: Diprivan should not be mixed
than 3 years: 9-15 mg/kg/ hour. Sedation: 0.3 - 4 major sepsis. Contains no antimicrobial
pancreatitis, post-operative fever, discoloration prior to administration with injections or infusion
mg/kg/hour up to 3 days preservatives. When aspirated, must be drawn
of urine following prolonged administration, fluids other than with 5% Dextrose in PVC bags
aseptically into sterile syringe or giving set
anaphylaxis - may include angioedema, or glass infusion bottles or lignocaine injection or
immediately after opening ampoule or breaking vial
bronchospasm, erythema & hypotension - sexual alfentanil injection in plastic syringes. The
seal. Administration must commence with or without
disinhibition, pulmonary oedema, post-operative neuromuscular-blocking agents, atracurium and
delay. Asepsis must be maintained for Diprivan &
unconsciousness mivacurium should not be given the same IV line
infusion instrument throughout infusion period. Any
as Diprivan without prior flushing
fluids added to Diprivan line must be administered
close to cannula site. Diprivan must not be
administered via microbiological filter. Single infusion
must not exceed 12 hours. At the end of the
procedure or at 12 hours, whichever is sooner, both
reservoir & infusion line must be discarded &
replaced as appropriate
Slow IV injection in a dose of 1 mg over 1 minute, Anaesthesia/surgery (myocardial depression). Avoid chlorpromazine, cimetidine, clonidine, cocaine,
Bronchospasm, bradycardia, depression, Hypersensitivity to propranolol, asthma,
repeated if necessary every 2 minutes until a maximum abrupt withdrawal, gradual withdrawal over a period digoxin, dihydroergotamine, dihydropyridine,
nausea, vomiting, dizziness, central nervous bradycardia, 2nd and 3rd degree AV block,
Propranolol HCl 1 mg/ml Injection Inderal Arrhythmias and thyrotoxicosis crisis of 10 mg has been given in conscious patients and 5 of 1 to 2 weeks is recommended. Bronchospastic calcium channel blockers, diltiazem,
system effects, muscle cramps, fluid retention, cardiogenic shock overt cardiac failure,
mg in patients under anaesthesia. CHILD: 25 - 50 disease, cerebrovascular insufficiency, congestive disopyramide, epinephrine, ergotamine,
skin rashes, dry mouth obstructive airway disease
mcg/kg slow IV with appropriate monitoring heart failure, diabetes mellitus, hepatic disease flecainide, flunarizine, fluvoxamine, furosemide,
risk of lignocaine toxicity increased

chlorpromazine, cimetidine, clonidine, cocaine,
Avoid abrupt withdrawal, bronchospastic disease, Bronchospasm, bradycardia, depression, Hypersensitivity to propranolol, asthma,
digoxin, dihydroergotamine, dihydropyridine,
Dysrythmias, tachycardia, hypertrophic obstructive congestive heart failure, diabetes, hepatic disease, nausea, vomiting, dizziness, central nervous bradycardia, 2nd and 3rd degree AV block,
Propranolol HCl 10 mg Tablet Inderal 10 - 40 mg 3 - 4 times daily calcium channel blockers, diltiazem,
cardiomyopathy (For cardiologist only) peripheral vascular disease, renal disease, system effects, muscle cramps, fluid retention, cardiogenic shock overt cardiac failure,
disopyramide, epinephrine, ergotamine,
myasthenia gravis, pregnancy, breast feeding skin rashes, dry mouth obstructive airway disease
flecainide, flunarizine, fluvoxamine, furosemide,
risk of lignocaine toxicity increased
i) Initially 80 mg twice daily increased as required to a
usual range of 160 - 320 mg daily. CHILD: Initial doses
of 1 mg/kg in divided doses, can be increased to 2 - 4
mg/kg/day in divided doses ii) Initial dose of 40 mg 2 - 3
times daily. Maintenance 120 - 240 mg daily iii) 40mg 4
chlorpromazine, cimetidine, clonidine, cocaine,
times daily for 2 - 3 days then 80 mg twice daily, Avoid abrupt withdrawal, bronchospastic disease, Bronchospasm, bradycardia, depression, Hypersensitivity to propranolol, asthma,
i) Hypertension ii) Angina iii) Myocardial infarct iv) digoxin, dihydroergotamine, dihydropyridine,
beginning 5 - 21 days after infarction iv) 10 - 40 mg 3 - congestive heart failure, diabetes, hepatic disease, nausea, vomiting, dizziness, central nervous bradycardia, 2nd and 3rd degree AV block,
Propranolol HCl 40 mg Tablet Inderal Cardiac arrhythmia v) Portal hypertension vi) Migraine calcium channel blocker, disopyramide,
4 times daily v) Initially 40 mg twice daily. The dose peripheral vascular disease, renal disease, system effects, muscle cramps, fluid retention, cardiogenic shock, overt cardiac failure,
vii) Thyrotoxicosis epinephrine, ergotamine, flecainide, flunarizine,
may be increased as required up to 160 mg twice daily myasthenia gravis, pregnancy, breast feeding skin rashes, dry mouth obstructive airway disease
fluvoxamine, furosemide, risk of lignocaine
vi) Initial prophylaxis dose: 40 mg 2 - 3 times daily. The
toxicity increased
dose may be increased at weekly intervals up to 160
mg daily vii) Adjunct: 10 - 40 mg 3 - 4 times daily.
CHILD: Arrythmias, thyrotoxicosis: 0.25 - 0.5 mg/kg 3 -
4 times daily as required
CHILD: Initial 5 - 7 mg/kg/day in divided doses every 8
Palliative treatment of hypothyroidism as an adjunct to hours. Maintenance: 1/3 to 2/3 of the initial dose in
ameliorate hyperthyrodism in preparation for surgical divided doses every 6 - 8 hours. ADULT: Initial dose: Pregnancy, lactation, bleeding disorders or easy
Propylthiouracil 50 mg Tablet - Renal impairment Gastric distress, headache, nausea, skin rash Dicumarol, warfarin, carbimazole
treatment or radioactive iodine therapy and in the 300 - 450 mg daily in divided doses every 8 hours. bruising
management of thyrotoxicosis crisis Maintenance: 100 - 150 mg daily in divided doses every
8 - 12 hours
The rapid administration of protamine is associated

5 ml slow IV injected over 10 minutes. If administered with a higher incidence of adverse haemodynamic
Heparin overdose and following cardiac or arterial
within 15 minutes of heparin dose, 1 mg will neutralise effects and anaphylactoid-like reactions. A solution
Protamine Sulphate 50 mg/5 ml surgery or dialysis procedures when required to Hypotension, bradycardia, hypersensitivity
- approximately 100 units of heparin. If longer time has of 10 mg/mL should be injected slowly over 1 to 3 Hypersensitivity to protamine products Not known
Injection neutralize the effects of heparin administered during reactions
elapsed, less protamine is required. Not more than 50 minutes to prevent haemodynamic effects and
extracorporeal circulation
mg should be injected at any one time anaphylactic-like reaction, patients with a history of
fish allergy may also develop sensitivity reaction
Trophic lesions in patients with arterial occlusive
Protein Free Haemodialysate 10% disease and with chronic venous insufficiency, burn
Solcoseryl Apply 3 - 5 times daily Burning sensation after application Allergic skin reactions Hypersensitivity to any component Not known
Jelly injuries, impaired wound healing, decubitus ulcers and
skin ulcer caused by irradiation
Eyes disorders e.g. burns, scalds, ulcers, prevention
Protein Free Haemodialysate 20% Burning sensation, allergic reactions may occur
Solcoseryl and treatment of radiation dermatitis, traumatic and Instill 1 drop 3 - 4 times daily Burning sensation after application Hypersensitivity to any component Topical antiviral drug such as acyclovir
Eye Gel after repeated application
ischaemic wound
Trophic lesions in patients with arterial occlusive
Protein Free Haemodialysate 5% disease and with chronic venous insufficiency, burn
Solcoseryl Apply 3 - 5 times daily Burning sensation after application Allergic skin reactions Hypersensitivity to any component Not known
Ointment injuries, impaired wound healing, decubitus ulcers and
skin ulcer caused by irradiation
Painful and inflammatory affliction on the oral mucosa,
Protein Free Haemodialysate Dental gums and lips, teething pain, denture pressure sores,
Solcoseryl Apply to lesions 3 - 5 times daily Burning sensation after application Not known Hypersensitivity to any component Not known
Adhesive Paste oral and maxillofacial surgery and dressing after
scaling
For peripheral arterial occlusive disease gangrene and
Arteriosclerotic and diabetic angiopathies: 4 - 6 ml IM,
other trophic lesions, cerebrovascular disease, chronic
IV or IA daily for first 2 weeks, after which the dose may
Protein Free Haemodialysate Injection Solcoseryl venous insufficiency, severe burns, irradiation lesions, Pregnancy, lactation Not known Hypersensitivity to any component Not known
be reduced. Myocardial infarct: 4 ml daily for 1 - 2
impaired wound healing, arteriosclerotic, diabetic
weeks
angiopathies and myocardial infarct
Nausea, vomiting, anorexia, abdominal pain and
ADULT and CHILD : 2 years and older - single dose Impaired liver function, anaemia, malnutrition and
Pyrantel Pamoate 125 mg Tablet Combantrin Intestinal nematodes discomfort, diarrhoea, headache, dizziness, Known hypersensitivity to pyrantel pamoate Piperazine
10mg/kg body weight once. Maximum 1 g pregnancy
drownsiness
Nausea, vomiting, anorexia, abdominal pain and
ADULT and CHILD : 2 years and older - single dose Impaired liver function, anaemia, malnutrition and
Pyrantel Pamoate 250 mg Tablet Combantrin Intestinal nematodes discomfort, diarrhoea, headache, dizziness, Known hypersensitivity to pyrantel pamoate Piperazine
10mg/kg body weight once. Maximum 1 g pregnancy
drownsiness
Liver toxicity depending on treatment duration &
concomitant therapy. Transient increase in
Concurrent use of pyrazinamide and zidovudine
ADULT & CHILD : 25 mg/kg daily or 35 mg/kg 3 times Slightly impaired liver function, hyperuricaemia, serum transminase levels, acute atrophy of the Porphyria, severe liver damage, acute liver
Pyrazinamide 500 mg Tablet - Tuberculosis may result in decreased efficacy of
weekly arthralgia, renal insufficiency, diabetes mellitus liver. Nausea, vomiting, anorexia, diarrhoea, disease, pregnancy, lactation
pyrazinamide. Cyclosporin, ethionamide
abdominal pain. Hyperuricaemia may occur with
dosages more than 2 g/day
Abdominal cramps, excessive sweating,
ADULT: 30 - 120 mg at suitable intervals throughout the
Bronchial asthma (extreme caution) or bronchitis, bronchoconstriction, lacrimation, bradycardia,
day, total daily dose 0.3 - 1.2 g. CHILD up to 6 years Potentiates actions of morphine derivatives and
Pyridostigmine Bromide 60 mg Tablet Mestinon Myasthenia gravis renal disease, cardiac dysrhythmias, cholinergic asystole, diaphoresis, diarrhoea, nausea, Intestinal or urinary obstruction
initially 30 mg, 6 - 12 years initially 60 mg, usual total barbiturates, succinylcholine
crisis vomiting, cramp, muscle fasciculation, asthenia,
daily dose 30 - 360 mg
miosis
i) Pyridoxine-dependent convulsions in infancy ii)
i) INFANT 4 mg/kg daily for short periods ii) 100 - 400 Pregnancy, lactation, neonatal seizures, concurrent Peripheral sensory neuropathy, hypotonia,
Sideroblastic anaemia iii) B6-deficient anaemia in adult
mg daily in divided doses iii) ADULT 20 - 50 mg up to 3 treatment with levodopa. Long term use in a dose of respiratory difficulties, nausea and other Hypersensitivity to pyridoxine or any component
Pyridoxine HCl 10 mg Tablet iv) Prophylaxis to peripheral neuritis in isoniazid Levodopa, penicillamine, selegiline, phenytoin
times daily iv) Prophylaxis 10 mg daily, therapeutic 50 200 mg or more daily has been associated with gastrointestinal complaints, photosensitivity, of preparation
therapy v) Nausea and vomiting of pregnancy and
mg 3 times daily v) 20 - 100 mg daily neuropathy vesicular lesions and bullous lesions
irradiation sickness
i) Pyridoxine-dependent convulsions in infancy ii)
i) INFANT 4 mg/kg daily for short periods ii) 100 - 400 Pregnancy, lactation, neonatal seizures, concurrent Peripheral sensory neuropathy, hypotonia,
Sideroblastic anaemia iii) B6-deficient anaemia in adult
mg daily in divided doses iii) ADULT 20 - 50 mg up to 3 treatment with levodopa. Long term use in a dose of respiratory difficulties, nausea and other Hypersensitivity to pyridoxine or any component
Pyridoxine HCl 50 mg/2 ml Injection iv) Prophylaxis to peripheral neuritis in isoniazid Levodopa, penicillamine, selegiline, phenytoin
times daily iv) Prophylaxis 10 mg daily, therapeutic 50 200 mg or more daily has been associated with gastrointestinal complaints, photosensitivity, of preparation
therapy v) Nausea and vomiting of pregnancy and
mg 3 times daily v) 20 - 100 mg daily neuropathy vesicular lesions and bullous lesions
irradiation sickness
i) Initial titration schedule over 4 days: 25 mg twice daily
on Day 1, increase in steps of 25 - 50 mg 2 to 3 times
daily on Days 2 and 3 to reach target dose of 300 - 400
mg daily by Day 4, given in 2 - 3 divided doses. Institute
further dose adjustments, if indicated, at intervals of 2
days or more, in steps of 25 - 50 mg twice daily ii) 100
Pregnancy, hepatic impairment, renal impairment, Headache, somnolence, weight gain, postural
mg (Day 1), 200 mg (Day 2), 300 mg (Day 3) & 400 mg
i) Schizophrenia ii) Short term treatment of acute manic cerebrovascular disease, hyperglycaemia and hypotension, tachycardia, palpitations, dizziness, Antihypertensives, cimetidine, CNS depressants,
(Day 4). Further dosage adjustments up to 800 mg/day
episodes associated with bipolar I disorder, either diabetes mellitus. Cardiovascular disease, use with rash, abdominal pain, constipation, dyspepsia, Hypersensitivity, severe CNS depression, bone alcohol, carbamazepine, barbiturates, valproate,
by Day 6 should be in increments of not more than 200
Quetiapine Fumarate 100 mg Tablet Seroquel monotherapy or adjunct to lithium or divalproex iii) drugs known to prolong QTc interval. Renal & anorexia, dry mouth, constipation, leucopenia, marrow suppression, blood dyscrasias, severe phenytoin, rifampicin, thioridazine, ketoconazole,
mg/day. Adjust dose within the range of 200 - 800
Treatment of depressive episodes associated with hepatic impairment. History of seizures & diabetes dyspepsia, elevated serum transaminases (ALT, hepatic disease, coma erythromycin. Other centrally-acting drugs,
mg/day depending on clinical response and tolerability
bipolar disorder mellitus. Pregnancy & lactation. Elderly. May affect AST), mild asthenia, peripheral oedema, weight alcohol, macrolide antibiotics
of the patient. Usual effective dose range: 400 - 800
ability to drive or operate machinery gain, syncope, rhinitis
mg/day iii) 50 mg ORALLY once a day on Day 1, then
100 mg once daily on Day 2, then 200 mg once daily on
Day 3, then 300 mg once daily on Day 4 (all doses
given at bedtime); patients requiring higher doses
should receive 400 mg on Day 5, increased to 600 mg
on Day 8 (week 1)
i) Initial titration schedule over 4 days: 25 mg twice daily
on Day 1, increase in steps of 25 - 50 mg 2 to 3 times
daily on Days 2 and 3 to reach target dose of 300 - 400
mg daily by Day 4, given in 2 - 3 divided doses. Institute
further dose adjustments, if indicated, at intervals of 2
days or more, in steps of 25 - 50 mg twice daily ii) 100
mg (Day 1), 200 mg (Day 2), 300 mg (Day 3) & 400 mg
i) Schizophrenia ii) Short term treatment of acute manic cerebrovascular disease, hyperglycaemia and hypotension, tachycardia, palpitations, dizziness, Antihypertensives, cimetidine, CNS depressants,
(Day 4). Further dosage adjustments up to 800 mg/day
episodes associated with bipolar I disorder, either diabetes mellitus. Cardiovascular disease, use with rash, abdominal pain, constipation, dyspepsia, Hypersensitivity, severe CNS depression, bone alcohol, carbamazepine, barbiturates, valproate,
by Day 6 should be in increments of not more than 200
Quetiapine Fumarate 200 mg Tablet Seroquel monotherapy or adjunct to lithium or divalproex iii) drugs known to prolong QTc interval. Renal & anorexia, dry mouth, constipation, leucopenia, marrow suppression, blood dyscrasias, severe phenytoin, rifampicin, thioridazine, ketoconazole,
mg/day. Adjust dose within the range of 200 - 800
Treatment of depressive episodes associated with hepatic impairment. History of seizures & diabetes dyspepsia, elevated serum transaminases (ALT, hepatic disease, coma erythromycin. Other centrally-acting drugs,
mg/day depending on clinical response and tolerability
bipolar disorder mellitus. Pregnancy & lactation. Elderly. May affect AST), mild asthenia, peripheral oedema, weight alcohol, macrolide antibiotics
of the patient. Usual effective dose range: 400 - 800
mg/day iii) 50 mg ORALLY once a day on Day 1, then
100 mg once daily on Day 2, then 200 mg once daily on
Day 3, then 300 mg once daily on Day 4 (all doses
given at bedtime); patients requiring higher doses
should receive 400 mg on Day 5, increased to 600 mg
on Day 8 (week 1)
i) & ii) 300 mg once daily on Day 1 and 600 mg on Day
cerebrovascular disease, hyperglycaemia and hypotension, tachycardia, palpitations, dizziness, Antihypertensives, cimetidine, CNS depressants,
2. Maintenance dose: 400 ? 800 mg once daily.
i) Schizophrenia ii) Moderate to severe manic episodes diabetes mellitus. Cardiovascular disease, use with rash, abdominal pain, constipation, dyspepsia, Hypersensitivity, severe CNS depression, bone alcohol, carbamazepine, barbiturates, valproate,
Quetiapine Fumarate 300 mg Maximum dose: 800 mg daily iii) 50 mg on Day 1, 100
Seroquel XR® in bipolar disorder iii) Major depressive episodes in drugs known to prolong QTc interval. Renal & anorexia, dry mouth, constipation, leucopenia, marrow suppression, blood dyscrasias, severe phenytoin, rifampicin, thioridazine, ketoconazole,
Extended Release Tablet mg on Day 2, 200 mg on Day 3 and 300 mg on Day 4.
bipolar disorder hepatic impairment. History of seizures & diabetes dyspepsia, elevated serum transaminases (ALT, hepatic disease, coma erythromycin. Other centrally-acting drugs,
Recommended daily dose is 300 mg. May be titrated up
mellitus. Pregnancy & lactation. Elderly. May affect AST), mild asthenia, peripheral oedema, weight alcohol, macrolide antibiotics
to 600 mg daily
Pregnancy, hepatic impairment, renal impairment,

Headache, somnolence, weight gain, postural
i) & ii) 300 mg once daily on Day 1 and 600 mg on Day
cerebrovascular disease, hyperglycaemia and hypotension, tachycardia, palpitations, dizziness, Antihypertensives, cimetidine, CNS depressants,
2. Maintenance dose: 400 ? 800 mg once daily.
i) Schizophrenia ii) Moderate to severe manic episodes diabetes mellitus. Cardiovascular disease, use with
rash, abdominal pain, constipation, dyspepsia, Hypersensitivity, severe CNS depression, bone alcohol, carbamazepine, barbiturates, valproate,
Quetiapine Fumarate 400 mg Maximum dose: 800 mg daily iii) 50 mg on Day 1, 100
Seroquel XR® in bipolar disorder iii) Major depressive episodes in drugs known to prolong QTc interval. Renal & anorexia, dry mouth, constipation, leucopenia, marrow suppression, blood dyscrasias, severe phenytoin, rifampicin, thioridazine, ketoconazole,
Extended Release Tablet mg on Day 2, 200 mg on Day 3 and 300 mg on Day 4.
bipolar disorder hepatic impairment. History of seizures & diabetes
dyspepsia, elevated serum transaminases (ALT, hepatic disease, coma erythromycin. Other centrally-acting drugs,
Recommended daily dose is 300 mg. May be titrated up
mellitus. Pregnancy & lactation. Elderly. May affect
AST), mild asthenia, peripheral oedema, weight alcohol, macrolide antibiotics
to 600 mg daily
Headache, fever, vomiting, muscle weakness,
By slow intravenous infusion (over 4 hours). ADULT : excitement, confusion, blindness, deafness, loss
20 mg/kg followed by 10 mg/kg every 8 hours. CHILD : of consciousness, fall in blood pressure, rash, Presence of haemoglobinuria during malaria or Amiodarone, terfenadine, thioridazine, digoxin,
Suppression or treatment of chloroquine-resistant Atrial fibrillation or other serious heart disease,
Quinine Dihydrochloride 600 mg/2 ml 20 mg/kg followed by 10 mg/kg every 12 hours, initial hypoglycaemia, dysphagia, epigastric pain, of optic neuritis, glucose-6-phosphate cimetidine, astemizole, cyclosporine, droperidol,
- Plasmodium Falciparum malaria in conjunction with myasthenia gravis, history of asthma, optic neuritis,
Injection dose should be half in patients who have received nausea, vomiting, disseminated intravascular dehydrogenase deficiency, hypersensitivity to mefloquine, methadone, pancuronium,
other antimalarial agents tinnitus, hypoglycaemia
quinine, quinidine or mefloquine during the previous 12 coagulation, thrombocytopenia, hepatotoxicity, quinine, myasthenia gravis rifapentine
or 24 hours ototoxicity (rare), haemolytic uremic syndrome,
interstitial nephritis
Headache, fever, vomiting, muscle weakness,
excitement, confusion, blindness, deafness, loss
300 - 600 mg daily. Treatment : 1.2 - 2 g daily in divided
of consciousness, fall in blood pressure, rash, Presence of haemoglobinuria during malaria or Amiodarone, terfenadine, thioridazine, digoxin,
Suppression or treatment of chloroquine-resistant doses. CHILDS less than 1 year : 100 - 200 mg daily, 1 - Atrial fibrillation or other serious heart disease,
hypoglycaemia, dysphagia, epigastric pain, of optic neuritis, glucose-6-phosphate cimetidine, astemizole, cyclosporine, droperidol,
Quinine Sulphate 300 mg Tablet - Plasmodium Falciparum malaria in conjunction with 3 years : 200 - 300 mg daily, 4 - 6 years: up to 500 mg myasthenia gravis, history of asthma, optic neuritis,
nausea, vomiting, disseminated intravascular dehydrogenase deficiency, hypersensitivity to mefloquine, methadone, pancuronium,
other antimalarial agents daily, more than 7 years : up to 1 g daily. All above tinnitus, hypoglycaemia
coagulation, thrombocytopenia, hepatotoxicity, quinine, myasthenia gravis rifapentine
doses are given for 7 days in 2 - 3 divided doses
ototoxicity (rare), hemolytic uremic syndrome,
interstitial nephritis
Agranulocytosis, thrombocytopenia, hepatic
i) Treatment and maintenance of erosive or ulcerative
i) 10-20 mg daily for 4-8 weeks, maintenance 10-20 mg Liver disease, hepatic impairment, elderly, dysfunction, jaundice, interstitial pneumonia, Hypersensitivity to rabeprazole or substituted Ampicillin, digoxin, iron, itraconazole,
Rabeprazole Sodium 20 mg Tablet Pariet gastroesophageal reflux disease (GERD) ii) Duodenal
daily ii) 20 mg daily at morning for up to 4-8 weeks pregnancy, lactation abdominal pain, diarrhoea, oedema, headache, benzimidazoles ketoconazole, warfarin
ulcers
dizziness, rash
Prophylaxis: 3 dose (1 ml each) schedule on days 0, 7
and 28. Booster dose after every 2 - 3 years. Post
Rabies Human Diploid Cell Vaccine Pre-exposure and post-exposure vaccination against exposure prophylaxis: use after attack of a potential Erythema of injection site, fever with mild
Imorab Allergy to neomycin Pregnancy, acute febrile illness Corticosteroids, immunosuppressives
(Lyophilised) Injection rabies rabid animal: 1 dose on days 0, 3, 7, 14 and 30. In asthenia
previously vaccinated individuals 2 doses on day 0 and
3
Has been associated with increased risk of
Prevention and treatment of post menopausal Elderly, excessive exercise, hypoglycaemia, breast thromboembolism (deep vein thrombosis, Women with child bearing potential, active Ampicillin and cholestyramine decrease
Raloxifene HCl 60 mg Tablet Evista 1 tablet daily
osteoporosis cancer pulmonary embolism) and superficial thromboembolic disorder, pregnancy raloxifene absorption
thrombophlebitis. Hot flushes and leg cramps
i) Initially 2.5 mg once daily, increased at intervals of 1 -
i) Hypertension and congestive heart failure ii) Post- 2 weeks to maximum 10 mg once daily ii) Initially 2.5 Hypersensitivity, history of angioedema with ACE
Nausea, dizziness & headache, dry cough,
myocardial infarction iii) Reducing risk of myocardial mg twice daily for 2 days then increased to maximum 5 Renal or hepatic impairment, hyperstimulated renin- inhibitors, bilateral renal artery stenosis or a Enhanced hypotensive effects by alcohol,
Ramipril 2.5 mg Tablet Tritace hypotension, hypokalemia, fatigue, pruritus, rash
infarction, stroke or cardiovascular death in diabetics or mg twice daily iii) Initially 1.25 - 2.5 mg once daily, angiotensin system single kidney with unilateral renal artery stenosis. alprostadil and anaesthetics
& fever ,pancreatitis, angioedema
patients with increased cardiovascular risks increased to 5 mg once daily after 1 week, maximum Pregnancy and lactation
dose: 10 mg once daily after 3 weeks
i) Initially 2.5 mg once daily, increased at intervals of 1 -

i) Hypertension and congestive heart failure ii) Post- 2 weeks to maximum 10 mg once daily ii) Initially 2.5 Hypersensitivity, history of angioedema with ACE
Nausea, dizziness & headache, dry cough,
myocardial infarction iii) Reducing risk of myocardial mg twice daily for 2 days then increased to maximum 5 Renal or hepatic impairment, hyperstimulated renin- inhibitors, bilateral renal artery stenosis or a Enhanced hypotensive effects by alcohol,
Ramipril 5 mg Tablet Tritace hypotension, hypokalemia, fatigue, pruritus, rash
infarction, stroke or cardiovascular death in diabetics or mg twice daily iii) Initially 1.25 - 2.5 mg once daily, angiotensin system single kidney with unilateral renal artery stenosis. alprostadil and anaesthetics
& fever ,pancreatitis, angioedema
patients with increased cardiovascular risks increased to 5 mg once daily after 1 week, maximum Pregnancy and lactation
dose: 10 mg once daily after 3 weeks
Headache, blepharitis, cataract, conjunctival

hemorrhage, dry eye, inflammatory disorder of
the eye, raised intraocular pressure, vitreous
Arterial thromboembolic events. Monitor intraoccular floaters, nasopharyngitis, upper respiratory
Treatment of Neovascular (wet) Age-Related Macular 0.5 mg (0.05 ml) by intravitreous injection. Initial loading pressure (IOP) and perfusion of the optic nerve infection. Arterial thromboembolism, atrial Active or suspected ocular/periocular infections. Hypersensitivity to ranibizumab or to any of the
Ranibizumab 10 mg/ ml Injection Lucentis®
Degeneration (ARMD) dose: 1 injection per month for 3 consecutive months following intravitreous injection. Pregnancy and fibrillation, cerebrovascular accident, atrophic Active intraocular inflammation excipients
lactation iris, central retinal vein occlusion - ischemic,
endophthalmitis, glaucoma, iridocyclitis, retinal
detachment, retinal hemorrhage, retinal tear,
thrombosis of retinal artery
Gastrointestinal disturbances, diarrhoea, altered
liver function tests (rarely liver damage),
headache, dizziness, rash and tiredness. Rare
H2-receptor antagonists should be used with caution
side-effects include acute pancreatitis,
in hepatic impairment, in renal impairment,
bradycardia, AV block, confusion, depression
i) 150 mg twice daily (at morning and night) or 300 mg pregnancy and in breast-feeding. H2-receptor
and hallucinations particularly in the elderly or
i) Benign gastric and duodenal ulcer ii) Reflux on night for 4-8 weeks. Maintenance: 150-300 mg on antagonists might mask symptoms of gastric cancer.
the very ill, hypersensitivity reactions (including Absorption may be reduced by concomitant
Ranitidine 150 mg Tablet Zantac oesophagitis iii) Non-ulcer dyspepsia iv) Zollinger- night ii) 150 mg twice daily or 300 mg on night for 8-12 Avoid in porphyrias. Ranitidine and phenytoin is not Hypersensitivity to ranitidine
fever, arthralgia, myalgia, anaphylaxis), blood administration with high doses (2 g) of sucralfate
Ellison Syndrome weeks iii) 150 mg daily or twice daily iv) 150 mg and recommended. If no alternatives exist, clinical
disorders (including agranulocytosis, leucopenia,
may be increased as necessary to 6 g/day monitoring of patient response, tolerance and serum
pancytopenia, thrombocytopenia) and skin
phenytoin concentrations is recommended,
reactions (including erythema multiforme and
especially during the first month of therapy
toxic epidermal necrolysis). There have been
occasional reports of gynaecomastia and
impotence
pregnancy and in breast-feeding. H2-receptor
antagonists might mask symptoms of gastric cancer.
Ranitidine 150 mg/10 ml Syrup Zantac Peptic ulcer disease CHILD 2-4 mg/kg 2 times daily. Maximum 300 mg daily Avoid in porphyrias. Ranitidine and phenytoin is not Hypersensitivity to ranitidine
recommended. If no alternatives exist, clinical
monitoring of patient response, tolerance and serum
impotence
i) 150 mg twice daily (at morning and night) or 300 mg pregnancy and in breast-feeding. H2-receptor
i) Benign gastric and duodenal ulcer ii) Reflux on night for 4-8 weeks. Maintenance: 150-300 mg on antagonists might mask symptoms of gastric cancer.
Ranitidine 300 mg Tablet Zantac oesophagitis iii) Non-ulcer dyspepsia iv) Zollinger- night ii) 150 mg twice daily or 300 mg on night for 8-12 Avoid in porphyrias. Ranitidine and phenytoin is not Hypersensitivity to ranitidine
Ellison Syndrome weeks iii) 150 mg daily or twice daily iv) 150 mg and recommended. If no alternatives exist, clinical
may be increased as necessary to 6 g/day monitoring of patient response, tolerance and serum
impotence
i) ADULT: Slow IV injection of 50 mg diluted to 20 ml in hepatic impairment, in renal impairment,
and given over at least 2 minutes. May be repeated pregnancy and in breast-feeding. H2-receptor
i) Benign gastric/ duodenal ulceration, reflux and hallucinations particularly in the elderly or
every 6-8 hours or IV infusion at rate of 25 mg/hour for antagonists might mask symptoms of gastric cancer.
oesophagitis, Zollinger Ellison Syndrome ii) Stress the very ill, hypersensitivity reactions (including Absorption may be reduced by concomitant
Ranitidine 50 mg/2 ml Injection Zantac 2 hours, may be repeated at 6-8 hours intervals or IM. Avoid in porphyrias. Ranitidine and phenytoin is not Hypersensitivity to ranitidine
ulcer prophylaxis in post-operative and high risk fever, arthralgia, myalgia, anaphylaxis), blood administration with high doses (2 g) of sucralfate
CHILD: 1 mg/kg/dose 6-8 hourly. ii) Initial slow IV recommended. If no alternatives exist, clinical
patients disorders (including agranulocytosis, leucopenia,
injection of 50 mg, then continuous infusion of 125-250 monitoring of patient response, tolerance and serum
mcg/kg/hour phenytoin concentrations is recommended,
impotence
Cytochrome P450 effect, erythromycin,
0.5 mg within 30 minutes before main meal. If patients Type 1 diabetes, diabetic ketoacidosis with or fluconazole, itraconazole, ketoconazole,
Type 2 diabetes mellitus (as monotherapy or in are transferred from another oral hypoglycaemic agent. Hypoglycaemia, transient visual disturbances, without coma. Pregnancy, lactation. Children phenytoin, rifampicin, ACE inhibitors, alcohol,
Patients more than 75 years, debilitated or
Repaglinide 2 mg Tablet Novonorm combination with metformin when metformin alone is Start dose with 1 mg before each main meal. Max gastrointestinal disturbances, hypersensitivity less than 12 years. Severe hepatic impairment, anabolic steroids, non-selective beta-blockers,
malnourished patients, renal impairment
inadequate) single dose: 4 mg before each main meal. Max 16 reactions of skin, arthralgia concomitant therapy with medicinal products MAOIs, NSAIDs, octreotide, salicylates,
mg/day which are CYP3A4 inhibitors or inducers corticosteroids, danazol, oral contraceptives,
sympathomimetics, thiazides, thyroid hormones
Haemolysis, anaemia, neutropenia, dry mouth, History of severe pre-existing cardiac disease,
hyperhidrosis, asthenia, chest pain, fatigue, haemoglobinopathies, severe debilitating
Exclude pregnancy before treatment, effective fever, headache, flu-like symptoms, malaise, medical conditions, chronic renal failure or
ADULT more than 18 years and more than 75 kg: 600 contraception essential during treatment and for 4 rigors, weight loss, dizziness, paresthesia, cretinine clearance less than 50 mL/minute,
For the treatment of chronic hepatitis C (in combination
Ribavirin 200 mg Capsule Rebetol mg twice daily. ADULT less than 75 kg: 400 mg in the months after treatment in women and for 7 months gastrointestinal disturbances, arthralgia, myalgia, severe psychiatric condition, severe hepatic Zidovudine, stavudine
with interferon alfa-2a/2b)
morning: 600 mg in the evening after treatment in men, routine monthly pregnancy central nervous system effects, viral infection, dysfunction, decompensated liver cirrhosis,
test cough, dyspnoea, pharyngitis, rhinitis, alopecia, autoimmune hepatitis, history of autoimmune
pruritus, rash, dry skin, parageusia, blurred disease, uncontrolled thyroid disease.
vision Pregnancy and lactation
Riboflavin deficiency often occurs in the presence of
CHILD: 2.5-10 mg/day in divided doses. ADULT: 5-30 other vitamin B deficiencies. High content of
Riboflavine 3 mg Tablet - For prevention and treatment of riboflavine deficiency Urine discoloration Hypersensitivity to riboflavin products Decreased absorption with probenecid
mg/day in divided doses riboflavin and pyridoxine in some commercial infant
formula
Flushing, itching, gastrointestinal reactions,
pseudomembranous colitis, hepatitis, May reduce the activity of anticoagulant,
CHILD: 20 mg/kg body weight daily in 1 - 2 doses. Up Patients with impaired liver function, pregnancy, thrombocytopenia, muscle weakness. Flu corticosteroids, cyclosporin, digitalis
Rifampicin 100 mg/5 ml Syrup Rifadin Tuberculosis and leprosy Hypersensitivity and jaundice patient
to 1 year: 10 mg/kg body weight in a single daily dose lactation syndrome may occur with intermittent dosage preparations, oral contraceptives, oral
regimens. May produce a reddish brown hypoglycaemics
discoloration of body fluids
i) ADULT: 450 - 600 mg as a single morning dose.
pseudomembranous colitis, hepatitis,
CHILD: 10 - 20 mg/kg body weight daily in 1 - 2 doses. May reduce the activity of anticoagulant,
i) Tuberculosis ii) Leprosy iii) Prophylaxis for Alcoholism, patients with impaired liver function, thrombocytopenia, muscle weakness. Flu
Rifampicin 150 mg Capsule Rifadin Directly observed therapy (DOT): 10 mg/kg twice Hypersensitivity and jaundice patient corticosteroids, cyclosporin, digitalis, oral
meningococcal meningitis pregnancy, lactation syndrome may occur with intermittent dosage
weekly or 3 times/week. Maximum: 600 mg ii) 600 contraceptives, oral hypoglycaemics
regimens. May produce a reddish brown
mg/day iii) 600 mg twice daily for 2 days
Reddish discoloration of body fluids & other body
secretions, increased hepatic enzyme levels, GI
disturbances, tiredness, drowsiness, headache,
Oral contraceptives, hormone replacement
Impaired renal/liver function, diabetes mellitus, dizziness, ataxia, leucopenia, eosinophilia,
therapy, anticoagulants, antidiabetics,
chronic alcoholism, undernourished patients, history flushing, itching, rash, disturbances in the
antihypertensives, cardiac drugs, antiepileptics,
of gout, convulsive disorders, acute porphyria. Avoid menstrual cycle, induction of crisis in Addison
Patient more than or 71 kg: 5 tab/day, 55 -70 kg: 4 History of drug-induced hepatitis, acute liver antacids, cimetidine, opioid analgesics,
Rifampicin 150 mg, Isoniazid 75 mg & tyramine and histamine-containing food. patients, "flu-like" symptoms, disturbances of
Rimcure 3-FDC Initial phase (2 months) of tuberculosis treatment tab/day, 38-54 kg: 3 tab/day, 30-37 kg: 2 tab/day. To be diseases regardless of their origin, peripheral disulfiram, anxiolytics, sedatives, sulfinpyrazone,
Pyrazinamide 400 mg Tablet Prophylactic administration of pyridoxine is liver function, hepatitis, peripheral neuropathy,
taken as a single dose neuritis allopurinol, colchicine, probenecid,
recommended. Avoid wearing contact lenses for at agranulocytosis, eosinophilia, thrombocytopenia,
corticosteroids, chloramphenicol, ketoconazole,
least 1 week after stopping therapy. Pregnancy. May allergic reactions, lupus erythematosus-like
dapsone, methadone, theophylline, ciclosporin A,
impair ability to drive or operate machinery syndrome, pellagra, gynaecomastia,
azathioprine, alcohol
hyperuricaemia, interstitial nephritis, dysuria,
mild arthralgia & myalgia, photosensitivity, fever,
porphyria
Reddish discoloration of body fluids, increased
hepatic enzyme levels, gastrointestinal
disturbances, tiredness, drowsiness, headache,
dizziness, ataxia, leucopenia, eosinophilia,
flushing, itching, rash, disturbances in the
Oral contraceptives, hormone replacement
menstrual cycle, induction of crisis in Addison
therapy, anticoagulants, antidiabetics,
Impaired renal or liver function, diabetes mellitus, patients, 'flu-like' symptoms, disturbances of liver
antihypertensives, cardiac drugs, antiepileptics,
chronic alcoholism, undernourished patients and function, hepatitis, peripheral neuropathy, Combined preparation not suitable for use in
Rifampicin 150 mg, Isoniazid 75 mg, ADULT: 30 - 37 kg: 2 tablets daily, 38 - 54 kg: 3 tablets antacids, cimetidine, opioid analgesics,
Treatment of both pulmonary and extrapulmonary history of gout, convulsive disorders, and acute agranulocytosis, eosinophilia, thrombocytopenia, children. History of drug-induced hepatitis, acute
Pyrazinamide 400 mg & Ethambutol daily, 55 - 70 kg: 4 tablets daily, more than 70 kg: 5 disulfiram, anxiolytics, sedatives, sulfinpyrazone,
tuberculosis, in the intensive treatment phase porphyria. Avoid tyramine and histamine-containing allergic reactions, lupus erythematosus-like liver diseases regardless of their origin,
HCl 275 mg Tablet tablets daily allopurinol, colchicine, probenecid,
food. May impair ability to drive or operate syndrome, pellagra, gynaecomastia, peripheral neuritis
corticosteroids, chloramphenicol, ketoconazole,
machinery hyperuricaemia, interstitial nephritis, dysuria,
dapsone, methadone, theophylline, cyclosporin
photosensitivity, porphyria, reversible retrobulbar
A, azathioprine, alcohol
neuritis with a reduction of visual acuity, central
scotoma and green-red color blindness,
jaundice, peripheral neuritis, confusion,
hallucinations, joint pain, fever, malaise, anorexia
and abdominal pain
i) ADULT: 450 - 600 mg as a single morning dose.
pseudomembranous colitis, hepatitis,
CHILD: 10 - 20 mg/kg body weight daily in 1 - 2 doses. May reduce the activity of anticoagulant,
i) Tuberculosis ii) Leprosy iii) Prophylaxis for Alcoholism, patients with impaired liver function, thrombocytopenia, muscle weakness. Flu
Rifampicin 300 mg Capsule Rifadin Directly observed therapy (DOT): 10 mg/kg twice Hypersensitivity and jaundice patient corticosteroids, cyclosporin, digitalis, oral
meningococcal meningitis pregnancy, lactation syndrome may occur with intermittent dosage
weekly or 3 times/week. Maximum: 600 mg ii) 600 contraceptives, oral hypoglycaemics
regimens. May produce a reddish brown
mg/day iii) 600 mg twice daily for 2 days
Nausea, vomiting, anorexia, headache,
Rifampicin: 600 mg once monthly, Dapsone: 100 mg dizziness, tachycardia, nervousness, insomnia, May reduce the activity of anticoagulant,
Patients with impaired liver function, pregnancy, Hypersensitivity to rifampicin, dapsone and
Rifampicin, Dapsone & Clofazimine MB Combi For the treatment of leprosy and tuberculosis daily, Clofazimine: 300 mg once monthly and 50 mg skin disorders, agranulocytosis, peripheral corticosteroids, cyclosporin, digitalis, oral
lactation clofazimine
daily (or 100 mg on alternate days) neuritis, psychosis, haemolysis, contraceptives, oral hypoglycaemics
methaemoglobinemia, hypersensitivity reactions
Hypernatraemia or fluid retention,
Congestive heart failure, circulatory insufficiency, Nausea, vomiting, diarrhoea, abdominal cramps,
hypersensitivity, sodium chloride solutions with
Ringer's Solution Injection (contained kidney dysfunction, hypoproteinaemia, cirrhotic congestive heart failure, hypertension,
As a source of electrolytes and water for preservatives in newborns for injection or
sodium chloride, potassium chloride - According to the needs of the patient disease, hypervolaemia, urinary tract obstruction tachycardia, fluid accumulation, irritability, Not known
hydration/replenishing of chloride flushing of intravenous lines or mixing
and calcium chloride) and patients receiving drugs that cause sodium restlessness, weakness, headache, dizziness,
medications, hypertonic saline abortifacient in
retention, eg corticosteroids or corticotropin obtundation, convulsions
pregnancies less than 15 weeks
Neuroleptic malignant syndrome, tardive dyskinesia,
QT prolongation, cardiovascular or cerebrovascular
disease or conditions that predispose patients to
orthostatic hypotension, hypothermia or
ADULT : 2 mg in 1 - 2 divided doses on first day then 4
hyperthermia, previous diagnosis of breast cancer or Somnolence, dizziness, hyperkinesia, nausea, Tramadol, increased risk of seizures.
mg in 1 - 2 divided doses on 2nd day then 6 mg in 1 - 2
prolactin-dependent tumours, renal insufficiency, extrapyramidal effects, constipation, anxiety, Carbamazepine, increased risperidone
divided doses on 3rd day (slower titration appropriate in
hepatic insufficiency, Lewy body dementia or headache, rhinitis, rash, dyspepsia, tachycardia, clearance. Levodopa, loss of levodopa efficacy.
some patients); usual range 4 - 8 mg daily; dose above
Parkinson's disease, seizure history, pathologic dry mouth, weight gain, sexual dysfunction, Hyperprolactinaemia, hypersensitivity to Clozapine, decreased risperidone clearance.
Risperidone 1 mg Tablet Risperdal Psychoses and schizophrenia 10 mg daily only if benefit outweigh risk (maximum 16
changes in blood count, dysphagia, elderly patients, hyperprolactinaemia, menstrual irregularities, risperidone products, prolonged QT interval Amphotericin, Class Ia and III antiarrhythmics,
mg daily). Elderly (or in hepatic or renal impairment):
hypotension, hypovolaemia, dehydration, agents severe hypotension, tardive dyskinesia, acetalozamide, central alpha2 agonists, systemic
initially 0.5 mg twice daily increased in steps of 0.5 mg
prolonging QT, risk of aspiration pneumonia. Known neuroleptic malignant syndrome and corticosteroids, diuretics, tricyclic
twice daily to 1 - 2 mg twice daily. Not recommended in
cardiovascular disease, dosage should be gradually hyperglycaemia antidepressants
children under 15 years
titrated as recommended, a dose reduction should
be considered when hypotension occurs. Epilepsy,
pregnancy ad lactation. May affect ability to drive or
operate machinery

Tramadol, increased risk of seizures.
ADULT: 2 mg in 1 - 2 divided doses on 1st day then 4 disease or conditions that predispose patients to Somnolence, dizziness, hyperkinesia, nausea,
Carbamazepine, increased risperidone
mg in 1 - 2 divided doses on 2nd day then 6 mg in 1 - 2 orthostatic hypotension, hypothermia or extrapyramidal effects, constipation, anxiety,
clearance. Levodopa, loss of levodopa efficacy.
divided doses on 3rd day (slower titration appropriate in hyperthermia, previous diagnosis of breast cancer or headache, rhinitis, rash, dyspepsia, tachycardia,
Clozapine, decreased risperidone clearance.
some patients); usual range 4 - 8 mg daily; dose above prolactin-dependent tumours, renal insufficiency, dry mouth, weight gain, sexual dysfunction,
Hyperprolactinaemia, hypersensitivity to Amphotericin, Class Ia and III antiarrhythmics,
Risperidone 1 mg/ml Oral Solution Risperdal Psychoses and schizophrenia 10 mg daily only if benefit outweighs risk (maximum 16 hepatic insufficiency, Lewy body dementia or hyperprolactinaemia, menstrual irregularities,
risperidone products, prolonged QT interval acetalozamide, central alpha2 agonists, systemic
mg daily). Elderly (or in hepatic or renal impairment): Parkinson's disease, seizure history, pathologic severe hypotension, tardive dyskinesia,
corticosteroids, diuretics, tricyclic
initially 0.5 mg twice daily increased in steps of 0.5 mg changes in blood count, dysphagia, elderly patients, neuroleptic malignant syndrome and
antidepressants, phenothiazines, some β-
twice daily to 1-2 mg twice daily. Not recommended in hypovolaemia, dehydration, agents prolonging QT, hyperglycaemia, insomnia, agitation, depression,
blockers, fluoxetine, use with other centrally
children under 15 years risk of aspiration pneumonia, hyperglycaemia and fatigue
acting drugs (caution)
diabetes mellitus, epilepsy, pregnancy and lactation.
May affect ability to drive or operate machinery

ADULT : 2 mg in 1 - 2 divided doses on first day then 4
hyperthermia, previous diagnosis of breast cancer or Somnolence, dizziness, hyperkinesia, nausea, Tramadol, increased risk of seizures.
mg in 1 - 2 divided doses on 2nd day then 6 mg in 1 - 2
prolactin-dependent tumours, renal insufficiency, extrapyramidal effects, constipation, anxiety, Carbamazepine, increased risperidone
divided doses on 3rd day (slower titration appropriate in
hepatic insufficiency, Lewy body dementia or headache, rhinitis, rash, dyspepsia, tachycardia, clearance. Levodopa, loss of levodopa efficacy.
some patients); usual range 4 - 8 mg daily; dose above
Parkinson's disease, seizure history, pathologic dry mouth, weight gain, sexual dysfunction, Hyperprolactinaemia, hypersensitivity to Clozapine, decreased risperidone clearance.
Risperidone 2 mg Tablet Risperdal Psychoses and schizophrenia 10 mg daily only if benefit outweigh risk (maximum 16
changes in blood count, dysphagia, elderly patients, hyperprolactinaemia, menstrual irregularities, risperidone products, prolonged QT interval Amphotericin, class Ia and III antiarrhythmics,
mg daily). Elderly (or in hepatic or renal impairment):
hypotension, hypovolaemia, dehydration, agents severe hypotension, tardive dyskinesia, acetalozamide, central alpha2 agonists, systemic
initially 0.5 mg twice daily increased in steps of 0.5 mg
prolonging QT, risk of aspiration pneumonia. Known neuroleptic malignant syndrome and corticosteroids, diuretics, tricyclic
twice daily to 1 - 2 mg twice daily. Not recommended in
cardiovascular disease, dosage should be gradually hyperglycaemia antidepressants
children under 15 years
titrated as recommended, a dose reduction should
be considered when hypotension occurs. Epilepsy,
pregnancy ad lactation. May affect ability to drive or
operate machinery

Treatment of acute and chronic schizophrenic May antagonize the effects of levodopa and
hyperthermia, previous diagnosis of breast cancer or
psychosis and other psychotic conditions, in which 25 mg IM every 2 weeks. Dose increments (if required) other dopamine-agonists. Carbamazepine and
Risperidone 25 mg Injection (Long prolactin-dependent tumours, renal and hepatic Weight gain, insomnia, depression, fatigue and Hyperprolactinaemia, hypersensitivity to
Risperdal Consta positive and negative symptoms are prominent. It also to 37.5 mg or 50 mg can be considered after a other hepatic enzyme inducers, phenothiazines,
Acting) insufficiency, Lewy body dementia or Parkinson's extra-pyramidal symptoms risperidone products, prolonged QT interval
alleviates affective symptoms associated with minimum of 4 weeks on each dosage tricyclic antidepressants and some beta-
disease, seizure history, pathologic changes in
schizophrenia blockers, fluoxetine
blood count, dysphagia, elderly patients,
hypovolaemia, dehydration, risk of aspiration
pneumonia, epilepsy, pregnancy and lactation. May
Risperidone 37.5 mg Injection (Long prolactin-dependent tumours, renal and hepatic Weight gain, insomnia, depression, fatigue and Hyperprolactinaemia, hypersensitivity to
Risperidone 50 mg Injection (Long prolactin-dependent tumours, renal and hepatic Weight gain, insomnia, depression, fatigue and Hyperprolactinaemia, hypersensitivity to
Pulmonary oedema (several cases reported with
fatal results). Maternal and fetal heart can
Patients with potential cardiac risks and cardiac Antepartum haemorrhage due to any cause but
increase. Frequently, nausea, vomiting, tremors,
IV 0.05 mg/min to be gradually increased by 0.05 abnormalities. Careful monitoring of patients with particularly placenta praevia and abruption
headache, erythema, nervousness, Corticosteroids, general anaesthesia. Other
mg/min every 10-15 minutes. IM injection: 10 mg 4-6 suspected cardiac disorder. Occult cardiac disease placenta. Eclampsia and severe pre-eclampsia,
Ritodrine HCl 50 mg/5 ml Injection Yutopar Prevention of preterm labour restlessness, jitterness, emotional upset, anxiety sympathomimetic amines, beta-adrenergic
hourly. Continue treatment for 12-48 hours after ceased may be unmasked. Diabetics or those receiving intra-uterine fetal deaths, chorioamnionitis,
or malaise. Infrequently, cardiac symptoms eg. blocking drugs, anaesthesia used in surgery
contraction potassium-depleting diuretics. Monitor patient's state maternal cardiac disorder, hyperthyroidism and
chest pain or tightness with or without ECG
of hydration, avoid fluid over load uncontrolled hypertension
abnormalities and cardiac arrhythmias. Impaired
liver function
ADULT: initially 300 mg twice daily, increase by 100 mg
Progressive or advanced HIV infection in combination Asthenia, gastrointestinal and neurological Decreased plasma concentration with
twice daily increments to 600 mg twice daily. For older
with other antiretroviral agents. Criteria for use: a) disturbances, anorexia, taste perversion, Hypersensitivity, lactation, severe hepatic phenobarbital, carbamazepine, dexamethasone,
Ritonavir 100 mg Capsule Norvir child who can swallow soft gelatin capsule; 250 mg/m2 Hepatic impairment
Clinical AIDS b) CD4 less than 350 cells or c) Viral load dyslipidemia, pancreatitis, hepatitis, Stevens- impairment phenytoin, rifampicin. Risk of myopathy with
twice daily for 2 days, if tolerate 400 mg/m2 twice daily
more than 10,000 copies/ml Johnson syndrome concurrent use of lovastatin, simvastatin
onwards
Progressive or advanced HIV infection in combination Asthenia, gastrointestinal and neurological Decreased plasma concentration with
with other antiretroviral agents. Criteria for use: a) ADULT: 400 - 600 mg twice daily. CHILD: 250 - 400 disturbances, anorexia, taste perversion, Hypersensitivity, lactation, severe hepatic phenobarbital, carbamazepine, dexamethasone,
Ritonavir 80 mg/ml Solution Norvir Hepatic impairment
Clinical AIDS b) CD4 less than 350 cells or c) Viral load mg/m2 twice daily dyslipidemia, pancreatitis, hepatitis, Stevens- impairment phenytoin, rifampicin. Risk of myopathy with
more than 10,000 copies/ml Johnson syndrome concurrent use of lovastatin, simvastatin
i) Treatment of patients with relapsed or chemo-

Hypersensitivity reaction may be severe, caution in
resistant low grade or follicular B-cell Non-Hodgkin's Angina, cardiac arrythmias, lymphopenia, fever,
patient receiving cardiotoxic chemotherapy, history
lymphoma ii) Adjunctive therapy with combination i) 375 mg/m2 body surface area administered as an IV chills, rigor, angioedema, nausea, rash,
of cardiovascular disease and pregnancy. Monitor Hypersensitivity or anaphylactic reactions to
chemoagents for aggressive Non-Hodgkin Lymphoma infusion through a dedicated line once weekly for 4 headache, dizziness, renal toxicity, hypotension,
Rituximab 500 mg/50 ml Injection Mabthera for tumour lysis syndrome. Use with caution in heart murine proteins or any component of the Cisplatin, live vaccines, rotavirus vaccines
iii) Severe active rheumatoid arthritis with inadequate weeks ii) Combination with CHOP as 375 mg/m2 BSA bronchospasm, mucocutaneous reactions,
disease and monitor for infusion-related events. formulation, breast feeding
response or intolerance to other disease-modifying anti- once every 3 to 4 weeks arrhythmias, chest pain, cough, rhinitis,
Medication for treatment of hypersensitivity must be
rheumatic drugs (DMARDs) including one or more dyspnoea
available for immediate use during administration
tumour necrosis factor (TNF) inhibitor therapies
Hemorrhagic risks, uncontrolled severe arterial
Active bleeding, hepatic disease associated with
hypertension, active ulcerative gastrointestinal Hypotension, constipation, diarrhoea, fever,
10 mg once daily. Initial dose should be taken 6 to 10 coagulopathy, severe renal impairment, CYP3A4 inhibitors (eg azole antifungals,
disease, vascular retinopathy, recent intracranial or oedema, unspecified pain, wound healing
Prevention of venous thromboembolism in patients hour post-surgery provided that haemostasis has been galactose intolerance, Lapp lactase deficiency or macrolides, HIV protease inhibitors, nefazodone,
Rivaroxaban 10 mg Tablet Xarelto ® intracerebral hemorrhage, recent brain, intraspinal or complications, increased transaminases, sleep
undergoing elective hip or knee replacement surgery established. Duration of treatment: Major hip surgery 5 glucose-galactose malabsorption, children and diltiazem & verapamil) & inducers (eg rifampicin,
intracerebral vascular abnormalities, spinal or disorders, dizziness, pruritus, post-procedural
weeks. Major knee surgery 2 weeks adolescent less than 18 year, pregnancy & barbiturates, phenytoin, St. John's wort)
ophthalmological surgery, hip fracture surgery, renal haemorrhage
lactation
and hepatic impairment
History of toxicity (especially excessive cholinergic
responses) related to other cholinesterase inhibitors
(e.g: tacrine), diabetes, cardiovascular/pulmonary
disease, gastrointestinal disorders, concurrent use
Initial dose 1.5 mg 2 times daily, may increase by 1.5 Cholinomimetic drugs, anticholinergic
For psychiatrists and neurologists only. Mild to of agents with anticholinergic activity, urogenital tract Nausea, vomiting, anorexia, dizziness,
mg 2 times daily every 2 weeks to maximum of 6 mg 2 Known hypersensitivity to the drug, other medications, succinylcholine-type muscle
Rivastigmine 1.5 mg Capsule Exelon moderately severe dementia associated with obstruction, parkinsonism, pregnancy, renal or diarrhoea, abdominal pain, loss of appetite,
times daily. If treatment is interrupted for several days, carbamate derivatives, severe liver impairment relaxants during anaesthesia, diazepam, digoxin,
Alzheimer's or Parkinson's disease hepatic insufficiency, high incidence of nausea and dyspepsia and headache
should be reinitiated at the lowest daily dose fluoxetine and warfarin
vomiting, concurrent NSAIDs, asthma or obstructive
pulmonary disease, anorexia, weight loss,
neurological conditions resulting in seizures,
extrapyramidal symptoms, tremor
Initial dose 1.5 mg 2 times daily. May be increased after
a minimum of 2 weeks of treatment to 3 mg 2 times Cholinomimetic drugs, anticholinergic
daily. Subsequently to 4.5 mg 2 times daily, up to Known hypersensitivity to the drug, other medications, succinylcholine-type muscle
Rivastigmine 2 mg/ml Oral Solution Exelon moderately severe dementia associated with obstruction, parkinsonism, pregnancy, renal or diarrhoea, abdominal pain, loss of appetite,
maximum of 6 mg 2 times daily. If treatment is carbamate derivatives, severe liver impairment relaxants during anaesthesia, diazepam, digoxin,
interrupted for several days, should be reinitiated at the fluoxetine and warfarin
lowest daily dose
Rivastigmine 3 mg Capsule Exelon moderately severe dementia associated with obstruction, parkinsonism, pregnancy, renal or diarrhoea, abdominal pain, loss of appetite,
Rivastigmine 4.5 mg Capsule Exelon moderately severe dementia associated with obstruction, parkinsonism, pregnancy, renal or diarrhoea, abdominal pain, loss of appetite,
Sick-sinus syndrome, conduction defects, urinary

obstruction, seizures in predisposed patients, Vomiting, nausea, anorexia, decreased appetite,
Initial, 4.6 mg/24 hr patch TOPICALLY once daily; after Cholinomimetic drugs, anticholinergic
Rivastigmine 4.6mg/24hr Transdermal Mild to moderately severe dementia associated with asthma or obstructive pulmonary disease. anxiety, depression, insomnia, dizziness, Hypersensitivity to rivastigmine, other carbamate
Exelon® patch 5 a minimum of 4 weeks and good tolerability, increase medications, succinylcholine-type muscle
Patch Alzheimer's or Parkinson's disease Pregnancy and lactation. Hepatic impairment, renal headache, diarrhoea, dyspepsia, abdominal derivatives and other components of the product
the dose to 9.5 mg/24 hr patch once daily relaxants during anaesthesia
impairment, anesthesia, low body weight, nicotine pain, application site reaction
use. May impair ability to drive or operate machinery

Rivastigmine 6 mg Capsule Exelon moderately severe dementia associated with obstruction, parkinsonism, pregnancy, renal or diarrhoea, abdominal pain, loss of appetite,
Sick-sinus syndrome, conduction defects, urinary

obstruction, seizures in predisposed patients, Vomiting, nausea, anorexia, decreased appetite,
Initial, 4.6 mg/24 hr patch TOPICALLY once daily; after Cholinomimetic drugs, anticholinergic
Rivastigmine 9.5 mg/24hr Mild to moderately severe dementia associated with asthma or obstructive pulmonary disease. anxiety, depression, insomnia, dizziness, Hypersensitivity to rivastigmine, other carbamate
Exelon®patch 10 a minimum of 4 weeks and good tolerability, increase medications, succinylcholine-type muscle
Transdermal Patch Alzheimer's or Parkinson's disease Pregnancy and lactation. Hepatic impairment, renal headache, diarrhoea, dyspepsia, abdominal derivatives and other components of the product
the dose to 9.5 mg/24 hour patch once daily relaxants during anaesthesia
impairment, anesthesia, low body weight, nicotine pain, application site reaction
use. May impair ability to drive or operate machinery
ADULT (usual) : Intubation: (rapid sequence intubation)

initial, 0.6-1.2 mg/kg IV Intubation: (tracheal intubation)
initial, 0.6 mg/kg IV Intubation: maintenance, 0.1-0.2
mg/kg IV repeated as needed. Intubation: maintenance, Hepatic, biliary tract and renal diseases, condition
Minimal histamine-releasing and cardiovascular
0.01-0.012 mg/kg/minute continuous IV infusion. associated with prolonged circulation time, Anaesthetics, other non-depolarising
As an adjunct to general anaesthesia to facilitate effects, high doses produce mild vagolytic
Skeletal muscle relaxation: initial, 0.6 mg/kg IV, neuromuscular disease, hypothermic condition, neuromuscular blocking agents, neostigmine,
endotracheal intubation, to provide skeletal muscle activity. Rare anaphylactic reactions. Itching and
Rocuronium Bromide 10 mg/ml maintenance, 0.1-0.2 mg/kg IV repeated as needed or obesity, hypokalaemia, hypermagnesaemia, edrophonium, pyridostigmine, aminopyridine
Esmeron relaxation during surgery and to facilitate mechanical erythematous reactions at the site of injection Hypersensitivity to rocuronium products
Injection 0.01-0.012 mg/kg/minute continuous IV infusion. hypocalcaemia, hypoproteinaemia, dehydration, derivatives, phenytoin or carbamazepine,
ventilation in adults, children and infants from 3 months and or generalized histaminoid reactions
CHILD: (usual) Intubation: (age 3 months-12 yr) initial, acidosis, hypercapnia, cachexia increases effects. noradrenaline, azathioprine, theophylline and
of age example bronchospasm and cardiovascular
0.6 mg/kg/dose IV, maintenance, 0.075-0.125 mg/kg IV Not recommended to drive or operate machinery calcium chloride
changes
as needed or 0.012 mg/kg/min continuous IV infusion. within 24 hour after full recovery
Skeletal muscle relaxation: (age 3 months-12 yr) initial,
0.6 mg/kg/dose IV, maintenance, 0.075-0.125 mg/kg IV
as needed or 0.012 mg/kg/min continuous IV infusion
Neuroleptics and other centrally active dopamine

antagonist, other dopamine agonists,
ciprofloxacin, high dose oestrogen, hormone
Several renal or hepatic failure, concomitant use of
Dizziness, headache, somnolence, nausea, replacement therapy, antiarrhythmias, inhibitors
0.25 mg 3 times daily gradually increasing till adequate alcohol, others central nervous system depressants
Parkinson disease in younger patients and patients vomiting, dyskinesia, hallucinations (dose Hypersensitivity to ropinirole, pregnancy and of CYP1A2 eg, cimetidine, erythromycin,
Ropinirole HCl 0.25 mg Tablet Requip response obtained up to a maximum of 24 mg/day. and neuroleptics. Pregnancy. May impair ability to
with dyskinesias, especially peak dose dyskinesias related), sleep attacks, postural hypotension, lactation, hepatic or severe renal impairment fluvoxamine, isoniazid, ritonavir and zileuton may
Most patients need 3-9 mg/day drive or operate machinery. Withdrawal should be
syncope, abdominal pain increase serum concentrations of ropinirole.
gradual
Ethanol, kava kava, gotu kola, valerian and St
John's wort may increase central nervous
system depression
Neuroleptics and other centrally active dopamine
antagonist, other dopamine agonists,
ciprofloxacin, high dose oestrogen, hormone
Several renal or hepatic failure, concomitant use of
Dizziness, headache, somnolence, nausea, replacement therapy, antiarrhythmias, inhibitors
0.25 mg 3 times daily gradually increasing till adequate alcohol, others central nervous system depressants
Parkinson disease in younger patients and patients vomiting, dyskinesia, hallucinations (dose Hypersensitivity to ropinirole, pregnancy and of CYP1A2 eg, cimetidine, erythromycin,
Ropinirole HCl 1 mg Tablet Requip response obtained up to a maximum of 24 mg/day. and neuroleptics. Pregnancy. May impair ability to
with dyskinesias, especially peak dose dyskinesias related), sleep attacks, postural hypotension, lactation, hepatic or severe renal impairment fluvoxamine, isoniazid, ritonavir and zileuton may
Most patients need 3-9 mg/day drive or operate machinery. Withdrawal should be
syncope, abdominal pain increase serum concentrations of ropinirole.
gradual
Ethanol, kava kava, gotu kola, valerian and St
John's wort may increase central nervous
system depression
Dose adjusted according to patient physical status and
Confusion, respiratory depression and
nature of procedure. i) Lumbar epidural: 15-25 ml of 7.5 Hypovolaemia, hypersensitivity to
convulsion, hypersensitivity, tachycardia, Hyaluronidase, propofol, rapacuronium,
mg/ml solution; Caesarean section, 15-20 ml of 7.5 Severe liver disease, acidosis, chronic renal ropivacaine/amide-type anaesthetics, severe
nausea, backache, Horner's syndrome. verapamil, antiarrhythmias, fluvoxamine,
i) Surgical anaesthaesia including obstetrics ii) Acute mg/ml solution in incremental doses ( max . total dose disease. Resuscitative equipment and drugs for hypotension, complete heart block. General
Ropivacaine HCl 2 mg/ml Injection Naropin Bradycardia, vomiting, paraesthesia, imipramine, theophylline and enoxacin.
pain management 150 mg). ii) lumbar epidural: 10-20 ml of 2mg/ml treating toxic reactions should be immediately contraindications related to epidural anaesthesia,
temperature elevation, headache, urinary Concomitant use with other related amide-type
solution followed by 10-15 ml of 2 mg/ml solution at available regardless of the local anaesthetic used, should
retention, dizziness, hypertension, hypotension, local anaesthetic
interval at of least 30 minutes. Labour pain 6-10 ml/hour be taken into account
rigors, tachycardia, anxiety, hypoesthesia
of 2mg/ml solution
Dose adjusted according to patient physical status and
Confusion, respiratory depression and
nature of procedure. i) Lumbar epidural: 15-25 ml of 7.5 Hypovolaemia, hypersensitivity to
convulsion, hypersensitivity, tachycardia, Hyaluronidase, propofol, rapacuronium,
mg/ml solution; Caesarean section, 15-20 ml of 7.5 Severe liver disease, acidosis, chronic renal ropivacaine/amide-type anaesthetics, severe
nausea, backache, Horner's syndrome. verapamil, antiarrhythmias, fluvoxamine,
i) Surgical anaesthaesia including obstetrics ii) Acute mg/ml solution in incremental doses ( max . total dose disease. Resuscitative equipment and drugs for hypotension, complete heart block. General
Ropivacaine HCl 7.5 mg/ml Injection Naropin Bradycardia, vomiting, paraesthesia, imipramine, theophylline and enoxacin.
pain management 150 mg). ii) lumbar epidural: 10-20 ml of 2mg/ml treating toxic reactions should be immediately contraindications related to epidural anaesthesia,
temperature elevation, headache, urinary Concomitant use with other related amide-type
solution followed by 10-15 ml of 2 mg/ml solution at available regardless of the local anaesthetic used, should
retention, dizziness, hypertension, hypotension, local anaesthetic
interval at of least 30 minutes. Labour pain 6-10 ml/hour be taken into account
rigors, tachycardia, anxiety, hypoesthesia
of 2mg/ml solution
Active liver disease, alanine transaminase levels
more than 2.5 times upper limit of normal, chronic
Diabetes mellitus with insulin resistant features, Hepatic impairment, history of heart failure,
heart failure (class I-II), diabetes mellitus type I,
combined with sulphonylureas, metformin, acarbose 4 mg once daily or in 2 divided doses, may be combination with insulin (risk of heart failure),
oedema, lack of adequate contraception in Headache, anaemia, hepatotoxicity, weight gain,
Rosiglitazone 4 mg Tablet and or insulin, delays introduction of insulin in type 2 increased to 8 mg/day in 1-2 divided doses after 12 pregnancy and breast feeding, diabetic Gemfibrozil, rifampicin
premenopausal anovulatory women. Potential oedema
diabetes mellitus already on maximal doses of two or week ketoacidosis, hypersensitivity to rosiglitazone
increased risk of myocardial ischaemia, exacerbate
more oral hypoglycaemic agents product
heart failure and other concurrent CV diseases such
as hypertension
Active liver disease, alanine transaminase levels
more than 2.5 times upper limit of normal, chronic
Diabetes mellitus with insulin resistant features, Hepatic impairment, history of heart failure,
heart failure (class I-II), diabetes mellitus type I,
combined with sulphonylureas, metformin, acarbose 4 mg once daily or in 2 divided doses, may be combination with insulin (risk of heart failure),
oedema, lack of adequate contraception in Headache, anaemia, hepatotoxicity, weight gain,
Rosiglitazone 8 mg Tablet Avandia and or insulin, delays introduction of insulin in type 2 increased to 8 mg/day in 1-2 divided doses after 12 pregnancy and breast feeding, diabetic Gemfibrozil, rifampicin
premenopausal anovulatory women. Potential oedema
diabetes mellitus already on maximal doses of two or week ketoacidosis, hypersensitivity to rosiglitazone
increased risk of myocardial ischaemia, exacerbate
more oral hypoglycaemic agents product
heart failure and other concurrent CV diseases such
as hypertension
Monitor renal and liver function. Predisposing factors
Initially 5-10 mg once daily increased if necessary at
for myopathy such as renal impairment, advanced
intervals of at least 4 weeks to 20 mg once daily,
age, hypothyroidism. Acute serious conditions Pharyngitis, headache, diarrhoea, dyspepsia, Active liver disease including elevated serum Warfarin, vitamin K antagonists, ciclosporin,
increased after further 4 weeks to 40 mg daily ONLY in
suggestive of myopathy or predisposing to the nausea, myalgia, asthenia, back pain, flu transaminases more than 3 times upper limit of gemfibrozil, lopinavir/ritonavir, antacids
severe hypercholesterolemia with high cardiovascular
Dyslipidaemia not responsive to atorvastatin 40 mg or development of renal failure secondary to syndrome, urinary tract infection, rhinitis, normal. Severe renal impairment (creatinine (aluminium and magnesium hydroxide),
Rosuvastatin 10 mg Tablet Crestor risk. Patient of Asian origin, patients on concomitant
equivalent doses of other statins rhabdomyolysis. Concurrent use of fibrates may sinusitis, altered liver function tests, clearance less than 30 mL/min). Patients with erythromycin, ketoconazole, spirinolactone,
ciclosporin/fibrate and patients with risk factors for
cause severe myositis and myoglobinuria, paraesthesia, abdominal pain, flatulence, myopathy. Patients receiving concomitant cimetidine, oral contraceptives, digoxin,
myopathy/rhabdomyolysis (including personal/family
concurrent use of other lipid-lowering constipation and vomiting ciclosporin. Pregnancy and lactation fenofibrate
history of muscular disorders/toxicity), the maximum
therapies/ciclosporin may increase the risk of
dose should be 20 mg daily
myopathy
Monitor renal and liver function. Predisposing factors
Initially 5-10 mg once daily increased if necessary at
for myopathy such as renal impairment, advanced
intervals of at least 4 weeks to 20 mg once daily,
age, hypothyroidism. Acute serious conditions Pharyngitis, headache, diarrhoea, dyspepsia, Active liver disease including elevated serum Warfarin, vitamin K antagonists, ciclosporin,
increased after further 4 weeks to 40 mg daily ONLY in
suggestive of myopathy or predisposing to the nausea, myalgia, asthenia, back pain, flu transaminases more than 3 times upper limit of gemfibrozil, lopinavir/ritonavir, antacids
severe hypercholesterolemia with high cardiovascular
Dyslipidaemia not responsive to atorvastatin 40 mg or development of renal failure secondary to syndrome, urinary tract infection, rhinitis, normal. Severe renal impairment (creatinine (aluminium and magnesium hydroxide),
Rosuvastatin 20 mg Tablet Crestor risk. Patient of Asian origin, patients on concomitant
equivalent doses of other statins rhabdomyolysis. Concurrent use of fibrates may sinusitis, altered liver function tests, clearance less than 30 mL/min). Patients with erythromycin, ketoconazole, spirinolactone,
ciclosporin/fibrate and patients with risk factors for
cause severe myositis and myoglobinuria, paraesthesia, abdominal pain, flatulence, myopathy. Patients receiving concomitant cimetidine, oral contraceptives, digoxin,
myopathy/rhabdomyolysis (including personal/family
concurrent use of other lipid-lowering constipation and vomiting ciclosporin. Pregnancy and lactation fenofibrate
history of muscular disorders/toxicity), the maximum
therapies/ciclosporin may increase the risk of
dose should be 20 mg daily
myopathy
Congenital or acquired cell mediated immune
Rubella Virus Vaccine (Live Pregnancy must be avoided for 28 days after rubella Mild lymph node enlargement and joint Immunoglobulin or blood products containing
Immunization against rubella (German measles) 0.5 ml SC as a a single dose deficiencies (including HIV), children born to HIV
Attenuated) Injection vaccination manifestations immunoglobulin
positive mothers and pregnancy
Slight tremor (particularly in the hands), nervous
tension, headache, peripheral dilatation and
Thyrotoxicosis, hyperthyroidism, cardiovascular
palpitations, tachycardia, arrhythmias, Antagonism with beta-blockers. Use with caution
2 ml may be inhaled up to 4 times daily over a period of disease, arrhythmias, susceptiility to QT-interval
Asthma and other conditions associated with reversible disturbances of sleep and behaviour in children, with additional adrenergic drugs, MAOI inhibitors
Salbutamol 0.5 % Inhalation Solution Ventolin 3 minutes per inhalation (0.5 ml diluted in 2.5 ml of prolongation, hypokalaemia, diabetes mellitus, not Hypersensitivity to any of their components
airways obstruction muscle cramps, hypersensitivity reactions or tricyclic antidepressants - increased risk of
normal saline by inhalation over 5 to 15 minutes) appropriate for managing premature labour,
including paradoxical bronchospasm, urticaria, tachycardia, agitation or hypomania
angioedema, hypotension, pulmonary oedema,
erythema multiforme
Haemorrhage, thrombocytopenia, tachycardia
and palpitations, erythema, ventricular ectopic
Thyrotoxicosis, pregnancy and lactation. Potential beats, myocardial ischaemia and infarction have
for paradoxical bronchospasm, patients with been reported following IV administration. Fine
500 mcg by SC/IM injection 4 hourly or 250 mcg by
cardiovascular disorders, hyperthyroidism, diabetes tremor (particularly in the hands), nervous Hypersensitivity, hyperthyroidism or
Asthma and other conditions associated with reversible slow IV. If required, by IV infusion, initially 5 mcg/min Monoamine oxidase inhibitors - increased risk of
Salbutamol 0.5 mg/ml Injection Ventolin mellitus, phaeochromocytoma, patients with history tension, headache, peripheral dilatation and thyrotoxicosis, tachycardia or tachycardiac
airways obstruction adjusted according to response and heart rate, usually tachycardia, agitation or hypomania
of aneursym and patients who are usually palpitations, tachycardia, arrhythmias, arrthymias, subvalvular aortic stenosis
in the range 3 - 20 mcg/min
responsive to sympathomimetics amines. Labour disturbances of sleep and behaviour in children.
and delivery may be complicated Muscle cramps and hypersensitivity reactions
including paradoxical bronchospasm, urticaria,
and angioedema

Thyrotoxicosis, pregnancy and lactation, tension, headache, peripheral dilatation and
hyperthyroidism, cardiovascular disease, palpitations, tachycardia, arrhythmias, Antagonism with beta-blockers. Use with caution
Asthma and other conditions associated with reversible ADULT : 100 - 200 mcg up to 3 - 4 times daily. CHILD : arrhythmias, susceptiility to QT-interval prolongation, disturbances of sleep and behaviour in children, with additional adrenergic drugs, MAOI inhibitors
Salbutamol 100 mcg/dose Inhalation Ventolin, Buventol Hypersensitivity to any of their components
airways obstruction 100 mcg increased to 200 mcg if necessary hypokalaemia, diabetes mellitus, not appropriate for muscle cramps, hypersensitivity reactions or tricyclic antidepressants - increased risk of
managing premature labour, pregnancy and including paradoxical bronchospasm, urticaria, tachycardia, agitation or hypomania
lactation angioedema, hypotension, pulmonary oedema,
erythema multiforme
Fine tremor (particularly in the hands), nervous Hypersensitivity to any of their components.
CHILD 2 - 6 years : 1 - 2 mg 3 - 4 times daily, 6 - 12
Asthma and other conditions associated with reversible tension, headache, peripheral dilatation and Premature labour e.g. placenta praevia, Monoamine oxidase inhibitors - increased risk of
Salbutamol 2 mg Tablet Ventolin years : 2 mg 3 - 4 times daily. CHILD over 12 years and Thyrotoxicosis
airways obstruction palpitations, tachycardia, arrhythmias, associated with toxaemia of pregnancy or tachycardia, agitation or hypomania
ADULT : 2 - 4 mg 3 - 4 times daily
disturbances of sleep and behaviour in children antepartum haemorrhage from whatever cause
Fine tremor (particularly in the hands), nervous

Asthma and other conditions associated with reversible CHILD 2 - 6 years : 1 - 2 mg 3 - 4 times daily, 6 - 12 tension, headache, peripheral dilatation and Monoamine oxidase inhibitors - increased risk of
Salbutamol 2 mg/5 ml Syrup Ventolin Thyrotoxicosis Hypersensitivity to any of their components
airways obstruction years : 2 mg 3 -4 times daily palpitations, tachycardia, arrhythmias, tachycardia, agitation or hypomania
disturbances of sleep and behaviour in children

Thyrotoxicosis, pregnancy and lactation, tension, headache, peripheral dilatation and
hyperthyroidism, cardiovascular disease, palpitations, tachycardia, arrhythmias, Antagonism with beta-blockers. Use with caution
CHILD : 100 - 200 mcg. Maintenance : 100 - 200 mcg 2
Salbutamol 200 mcg Inhalation Asthma and other conditions associated with reversible arrhythmias, susceptiility to QT-interval prolongation, disturbances of sleep and behaviour in children, with additional adrenergic drugs, MAOI inhibitors
- 4 times daily. ADULT : 100 - 400 mcg. Maitenance : Hypersensitivity to any of their components
Powder airways obstruction hypokalaemia, diabetes mellitus, not appropriate for muscle cramps, hypersensitivity reactions or tricyclic antidepressants - increased risk of
100 - 400 mcg 2 - 4 times daily
managing premature labour, pregnancy and including paradoxical bronchospasm, urticaria, tachycardia, agitation or hypomania
lactation angioedema, hypotension, pulmonary oedema,
erythema multiforme
Haemorrhage, thrombocytopenia, tachycardia
and palpitations, erythema, ventricular ectopic
Infusions containing 5 mg in 500ml (10 mcg/ml) at the Potential for paradoxical bronchospasm, patients
beats, myocardial ischaemia and infarction have Hypertensive crisis and other adverse effects
rate of 10 - 45 mcg/min increased at intervals of 10 with cardiovascular disorders, hyperthyroidism,
been reported following IV administration. Fine occur frenquently with the concurrent use of
minutes until evidence of patient response as shown by diabetes mellitus, phaeochromocytoma, patients with Hypersensitivity, hyperthyroidism or
tremors (particularly in the hands), nervous indirect-acting sympathomimetics. Concomitant
Salbutamol 5 mg/5 ml Injection Ventolin Prevention of uncomplicated premature labour only reduction of strength, frequency or duration of history of aneurysm and patients who are usually thyrotoxicosis, tachycardia or tachycardic
tension, headache, peripheral dilatation and administration of salbutamol and other beta-2
contractions; maintain rate for 1 hour after contractions responsive to sympathomimetic amines. Labour and arrthymias, subvalvular aortic stenosis
palpitations, tachycardia, arrhythmias. Muscle agonists with corticosteroids, diuretics or
have stopped, then gradually reduce by 50% every 6 delivery may be complicated. Thyrotoxicosis,
cramps and hypersensitivity reactions including xanthines increases the risk of toxicity
hours pregnancy and lactation
paradoxical bronchospasm, urticaria and
angioedema
Nausea, anorexia, fever, blood disorders
i) ADULT, acute attack 1-2 g 4 times daily until (megaloblastic anaemia), hypersensitivity
remission occurs (if necessary corticosteroids may also Hepatic or renal impairment, G6PD deficiency, risk reactions (including exfoliative dermatitis,
be given), reducing to a maintenance dose of 500 mg 4 of haematological and hepatic toxicity (differential epidermal necrolysis, pruritus,
times daily, CHILD over 2 years, acute attack 40-60 white cell, red cell and platelet counts initially and at photosensitisation, anaphylaxis, serum sickness,
i) Treatment of inflammatory bowel disease of Hypersensitivity to sulfonamides and salicylates,
Salicylazosulphapyridine mg/kg daily, maintenance dose 20-30 mg/kg daily ii) monthly intervals for first 3 months, liver function ocular complications (including periorbital Reduced absorption of folate, digoxin,
Salazopyrin ulcerative colitis and Crohn's disease ii) Rheumatoid acute intermittent porphyria and children less
(Sulfasalazine) 500 mg Tablet ADULT, initially; 0.5-1 g/day, increase weekly to tests at monthly intervals for first 3 months), kidney oedema), stomatitis, parotitis, ataxia, aseptic antibacterial
arthritis than 2 years
maintenance dose of 2 g/day in 2 divided doses, function tests at regular intervals, upper gastro- meningitis, vertigo, tinnitus, insomnia,
maximun 3 g/day. CHILD over 6 years, juvenile intestinal side-effects common over 4 g daily, depression, hallucinations, kidney reactions
rheumatoid arthritis: 30-50 mg/kg/day in 2 divided porphyria (including proteinuria, crystalluria, haematuria),
doses up to a maximum of 2 g/day oligospermia, urine may be coloured orange,
bone marrow depression, peripheral neuropathy
Salicylic Acid 1 - 2% in Avoid contact with eyes and other mucous Hypersensitivity, use in children less than 2
- Seborrhoeic capitis Apply to affected areas Local irritation Not known
Hydrocortisone 1% Ointment membranes years, diabetes with impaired circulation
Seborrhoeic dermatitis, scalp psoriasis and Hypersensitivity to salicylic acid. Age less than 2
Salicylic Acid 2 - 10% Cream - Apply sparingly to the affected area 2-3 times daily Avoid contact with eyes and mucous membranes Local irritation Not known
hyperkeratotic skin conditions years, diabetes with impaired circulation
Seborrhoeic dermatitis, scalp, psoriasis and Hypersensitivity to salicylic acid. Age less than 2
Salicylic Acid 2 - 10% Ointment - Apply sparingly to the affected area 2-3 times daily Avoid contact with eyes and mucous membranes Local irritation Not known
hyperkeratotic skin disorders years, diabetes with impaired circulation
Seborrhoeic dermatitis, scalp, psoriasis and Apply sparingly to the affected area 2-3 times daily. Hypersensitivity to salicylic acid. Age less than 2
Salicylic Acid 2 % Lotion - Avoid contact with eyes and mucous membranes Local irritation Not known
hyperkeratotic skin conditions Wash with cleanser 2 - 3 times per day years, diabetes, impaired circulation
Apply sparingly to the affected area 2-3 times daily. Hypersensitivity to salicylic acid. Age less than 2
Salicylic Acid 20% Ointment - Plantar warts Avoid contact with eyes and mucous membranes Local irritation Not known
Wash with cleanser 2-3 times per day years, diabetes, impaired circulation
Concurrent use with varicella vaccine may result
Salicylic Acid, Lactic Acid and Hypersensitivity use in children less than 2
Collomack Hardened skin, corns, collosities and warts One drop to be applied to the affected area twice daily Avoid contact with eyes and mucous membranes Local irritation in an enhanced risk of developing Reye's
Oxypolyethoxydodicane Solution years, diabetes impaired circulation
syndrome
Salicylic Acid, Starch, Zinc Oxide Apply the paste liberally and carefully to the lesionsContact with the eyes, mouth and other mucous
Lassar's Use as a protective or base Local irritation Hypersensitivity to any component Not known
Paste twice daily membranes should be avoided
Not for acute unstable or acutely deteriorating
asthma. Active or quiescent pulmonary tuberculosis,
Hoarseness and dystonia, throat irritation,
thyrotoxicosis. When transferring from systemic to Hypersensitivity to any of the ingredients of
Salmeterol 25 mcg and Fluticasone Regular treatment of reversible obstructive airways ADULT and CHILD more than 12 years : 1 - 2 puff twice headache, oropharyngeal candidiasis and Beta-blockers, strong CYP3A4 inhibitors e.g.
Seretide inhaled steroid therapy, monitor adrenocortical salmeterol, fluticasone or any component of the
Propionate 125 mcg Inhalation diseases including asthma daily. CHILD over 4 years : 1 puff twice daily palpitations, tremor, cardiac arrhythmias (atrial ketoconazole, ritonavir
function regularly and withdraw systemic product
fibrillation and supraventricular tachycardia)
corticosteroid therapy gradually. Pregnancy and
lactation
Hoarseness and dystonia, throat irritation,
Salmeterol 50 mcg and Fluticasone Regular treatment of reversible obstructive airways ADULT and CHILD more than 12 years : 1 - 2 puff twice headache, oropharyngeal candidiasis and Beta-blockers, strong CYP3A4 inhibitors e.g.
Propionate 250 mcg Inhalation diseases including asthma daily. CHILD over 4 years : 1 puff twice daily palpitations, tremor, cardiac arrhythmias (atrial ketoconazole, ritonavir
fibrillation and supraventricular tachycardia)
lactation
i) Regular treatment of reversible obstructive airways Hoarseness and dystonia, throat irritation,
Salmeterol 50 mcg and Fluticasone diseases including asthma ii) Chronic obstructive i) ADULT and CHILD more than 12 years : 1 puff twice headache, oropharyngeal candidiasis and Beta-blockers, strong CYP3A4 inhibitors e.g.
Propionate 500 mcg Inhalation pulmonary disease including chronic bronchitis and daily ii) ADULT 1 puff twice daily palpitations, tremor, cardiac arrhythmias (atrial ketoconazole, ritonavir
emphysema fibrillation and supraventricular tachycardia)
lactation
For treatment of shock due to burns, crushing injuries,
abdominal emergencies and where there is a
Monitor blood pressure especially with rapid
Selected Plasma Protein 5 g/100 ml predominant loss of plasma fluids and red blood cells, ADULT 12.5-25 g (250-500 ml) by IV. CHILD usual Hypotension, flushing, urticaria, back pain, Cardiopulmonary bypass, chronic heart failure, Not mixed with protein hydrolysates, solution
Plasmanate infusion, hepatic dysfunction, may contain infectious
Injection emergency treatment of shock due to haemorrhage dose 33 ml/kg body weight at rate of 5-10 ml/min headache, nausea increased blood volume, severe anaemia with alcohol
agents (hepatitis C)
and in infants and small children in the initial therapy of
shock due to dehydration and infection
History of peptic ulcer, pregnancy and lactation,
elderly, concurrent use of tricyclic antidepressants,
Extrapyramidal symptoms not related to Hyperpyrexia and central nervous system
uncontrolled hypertension. Suicidal ideation and Hypotension, nausea, confusion, agitation,
dopamine deficiency, thyrotoxicosis, narrow toxicity with pethidine. Hypertension and central
Only for treatment of late stage Parkinsonism with on 5 mg twice daily at breakfast and lunch. Maximum 10 behavior or worsening depression, increased risk hallucination, dyskinesia, sleep disturbances,
Selegiline HCl 5 mg Tablet Jumex angle glaucoma agitated psychosis, nervous system excitation with fluoxetine and
and off phenomenon mg/day during the first few months of therapy or following psychosis, constipation, dry mouth, headache,
hypersensitivity to selegiline products. sertraline. Hypotension with MAOIs.
changes in dosage (particularly in children, tremor, dizziness
Pregnancy Carbamazepine, amitriptyline, amphetamine
adolescents and young adults with major depressive
disorder)
Dandruff: apply 5-10 mL topically twice weekly for 2
weeks, then 1-4 times per month, as needed, leave on
Avoid contact with eyes, mucous membranes, Oiliness or dryness of hair and scalp, hair
for 2-3 min, then rinse thoroughly. Seborrheic dermatitis Acute inflammation or exudation, broken skin,
Selenium Sulphide 2.5% Shampoo Selsun Dandruff, seborrheic dermatitis of scalp inflamed or broken skin or to extensive areas of the discoloration, cutaneous sensitization and Not known
of scalp: apply 5-10 mL topically twice weekly for 2 hypersensitivity to drug
skin alopecia
weeks, then 1-4 times per month, as needed, leave on
for 2-3 min, then rinse thoroughly
Male sexual dysfunction, gastrointestinal
MAO inhibitors, serotonergic drugs,
complain, tremor, dizziness, insomnia,
caffeine/ergotamine, cimetidine, lithium,
Depression, obsessive-compulsive disorder: 50 Concomitant use with tryptophan and fenfluramine, headache, dry mouth, somnolence, ejaculatory
metoprolol, phenytoin, propranolol, warfarin,
mg/day. Panic disorder: Initially 25 mg/day. After 1 impaired hepatic function, electroconvulsive therapy, dysfunction, dyspepsia, decreased libido,
Major depression, obsessive-compulsive disorder Concurrent use or recent use of MAOIs, alcohol, central nervous system depressants,
Sertraline HCI 50 mg Tablet Zoloft week, increase dose to 50 mg/day. All dose changes abnormal bleeding, avoid abrupt discontinuation, sweating, anorexia, agitation, visual
(OCD), panic disorder hypersensitivity to sertraline products carbamezepine, clozapine, cyclosporine,
should be made at intervals of more than 1 week, max: hyponatraemia, history of seizures, MAO inhibitors, disturbances, serotonin syndrome, withdrawal
NSAIDs, aspirin, erythromycin, metoclopramide,
200 mg/day uricosuric effect syndrome, rash, pharyngitis, purpura,
tramadol, St. John's wort, tolbutamide, tricyclic
agranulocytosis, elevated liver enzyme,
antidepressants, zolpidem
antidepressants increase the risk of suicidal
Avoid the use of flow rates of less than 2
litres/minute with soda lime in patients with renal Cardiorespiratory depression, hypotension,
Isoniazid, nitrous oxide, thiopental, midazolam,
disease. Raised intracranial pressure, cardiac, malignant hyperthermia, agitation,
phenobarbital, primidone, rocuronium,
To be used only for i) induction and ii) maintenance of i) Up to 8% in oxygen or nitrous oxide-oxygen mixture respiratory, renal or hepatic impairment, elderly or laryngospasm, increased cough, salivation, Hypersensitivity to sevoflurane/halogenated
Sevoflurane Liquid Sevorane vecuronium, atracurium, succinylcholine,
anaesthesia ii) maintenance: 1 - 3% obese patients. Maintenance of haemodynamic acute renal failure, shivering, nausea, vomiting, anaesthetics, malignant hyperthermia
tubocurarine, verapamil. Potentiates action of
stability is important in patients with coronary artery rarely dystonic movements in children,
non-depolarising muscle relaxants
disease. Concomitant use with adrenaline or other postoperative hepatitis and seizure-like activity
sympathomimetics. Pregnancy and lactation
Chronic application to conjunctiva, mucous Hypersensitivity to silver nitrate or any Can react with alkali released from soda glass
Silver Nitrate 0.5% Lotion - Use as antiseptic Apply undiluted to affected area for a limited period Burning and skin irritation, staining of the skin
surfaces or open wounds lead to argyria component bottle
Those allergic to sulfonamides may show cross-
Transient leucopenia has occurred with topical Hypersensitivity to silver or to silver
Prevention and treatment of infections in severe burns, sensitivity to silver sulfadiazine. Haemolysis may Concomitant cimetidine therapy may increase
Burns: Apply 3 mm thick layer twice daily with sterile silver, haemolytic anaemia, probable febrile sulphadiazine. Pregnant women at or near term
Silver Sulfadiazine 1% Cream Flamazine leg ulcers where infections may prevent healing and for occur with glucose-6-phosphate deficiency. the likelihood of causing leucopenia in silver
applicator. Leg ulcer: apply at least 3 times a week reaction, irritation, itching and burning at the (increased kernicterus). Preterm infants or
the prophylaxis of infections in skin grafting Accumulation may occur in renal or hepatic sulfadiazine-treated burn patients
application site, argyria, hyperpigmentation newborns during first two months
insufficiency
persistent. May cause myopathy and renal failure Abdominal pain, flatulence, constipation, May cause slight elevation of serum digoxin.
Hypercholesterolaemia and coronary heart disease due to rhabdomyolysis. Concomitant administration asthenia and headache, rarely hepatitis, Hypersensitivity to simvastatin products, active Cholestyramine and colestipol increase
Simvastatin 10 mg Tablet Zocor 10 - 20 mg once daily. Maximum: 80 mg daily
intolerant or not responsive to other forms of therapy of fibrates, nicotinic acid, immunosuppressives hypersensitivity syndrome, upper respiratory liver disease, pregnancy and lactation bioavailability of simvastatin. Increased
including ciclosporin, macrolide antibiotics infection concentrations with mibefradil
ketoconazole or nefazodone may increase the risk
of myopathy
of myopathy
of myopathy
ADULT over 18 years, 100 mg once daily. Dosage in Ciclosporine: Sitagliptin mean peak plasma
Management of diabetes in patients with renal failure
renal failure: 50 mg once daily if creatinine clearance Should not be used in patient with type 1 diabetes or Gastrointestinal disturbances, peripheral concentrations may be increased modestly
where metformin is contraindicated and elderly with
equal or more than 30 to equal or less than 50 mL/min. for the treatment of diabetic ketoacidosis, pregnancy, oedema, upper respiratory tract infection, Ketoacidosis; pregnancy; breast-feeding; History (approximately 68%), which is not expected to
multiple co morbidities that always experience
Sitagliptin 100 mg Tablet Januvia 25 mg orally once if creatinine clearance less than 30 lactation. Dosage adjustments are needed in nasopharyngitis, pain, osteoarthritis, less of a serious hypersensitivity reaction to be clinically important. Digoxin: Digoxin mean
hypoglycemia with other antidiabetic.. Not to be used in
mL/min or with end stage renal disease requiring patients with moderate or severe renal function commonly anorexia, headache, drowsiness, Sitagliptin, such as anaphylaxis or angioedema peak plasma levels may be increased slightly
diabetic patient whose sugar control, HBA1c is more
hemodialysis, may be administered without regard to impairment dizziness, hypoglycaemia, osteoarthritis (approximately 18%); no dosage adjustment is
than 9%
the timing of hemodialysis recommended. Ketoconazole
ADULT over 18 years, 100 mg once daily. Dosage in Ciclosporine: Sitagliptin mean peak plasma
Management of diabetes in patients with renal failure
renal failure: 50 mg once daily if creatinine clearance Should not be used in patient with type 1 diabetes or Gastrointestinal disturbances, peripheral concentrations may be increased modestly
where metformin is contraindicated and elderly with
equal or more than 30 to equal or less than 50 mL/min. for the treatment of diabetic ketoacidosis, pregnancy, oedema, upper respiratory tract infection, Ketoacidosis, pregnancy, breast-feeding. History (approximately 68%), which is not expected to
multiple co-morbidities that always experience
Sitagliptin 25 mg Tablet Januvia 25 mg orally once if creatinine clearance less than 30 lactation. Dosage adjustments are needed in nasopharyngitis, pain, osteoarthritis, less of a serious hypersensitivity reaction to be clinically important. Digoxin: Digoxin mean
hypoglycemia with other antidiabetic.. Not to be used in
mL/min or with end stage renal disease requiring patients with moderate or severe renal function commonly anorexia, headache, drowsiness, Sitagliptin, such as anaphylaxis or angioedema peak plasma levels may be increased slightly
diabetic patient whose sugar control, HBA1c is more
hemodialysis, may be administered without regard to impairment dizziness, hypoglycaemia, osteoarthritis (approximately 18%); no dosage adjustment is
than 9%
the timing of hemodialysis recommended. Ketoconazole
Ciclosporine: Sitagliptin mean peak plasma
Management of diabetes in patients with renal failure ADULT over 18 years, 100 mg once daily. Dosage in
Should not be used in patient with type 1 diabetes or Gastrointestinal disturbances, peripheral concentrations may be increased modestly
where metformin is contraindicated and elderly with renal failure: 50 mg once daily if CrCl equal or more
for the treatment of diabetic ketoacidosis, pregnancy, oedema, upper respiratory tract infection, Ketoacidosis, pregnancy, breast-feeding. History (approximately 68%), which is not expected to
multiple co morbidities that always experience than 30 to equal or less than 50 mL/min. 25 mg orally
Sitagliptin 50 mg Tablet Januvia lactation. Dosage adjustments are needed in nasopharyngitis, pain, osteoarthritis, less of a serious hypersensitivity reaction to be clinically important. Digoxin: Digoxin mean
hypoglycemia with other antidiabetic.. Not to be used in once if CrCl less than 30 mL/min or with ESRD
patients with moderate or severe renal function commonly anorexia, headache, drowsiness, Sitagliptin, such as anaphylaxis or angioedema peak plasma levels may be increased slightly
diabetic patient whose sugar control, HBA1c is more requiring hemodialysis, may be administered without
impairment dizziness, hypoglycaemia, osteoarthritis (approximately 18%); no dosage adjustment is
than 9% regard to the timing of hemodialysis
recommended. Ketoconazole
Nausea, vomiting, angioneurotic, oedema and
hyperthyroidism. When given by injection may
cause nausea, metallic taste, vomiting, flushing
and sensations of heat, weakness, dizziness,
headache, coughing, rhinitis, sweating,
Asthma or a history of allergy, hypersensitivity to
sneezing, lachrymation, visual disturbances,
contrast media or to iodine severe hepatic or renal
pruritus, salivary gland enlargement, pallor,
impairment or others who may be at increased risk
tachycardia, bradycardia, transient ECG
of renal failure, dehydrated patients should have
abnormalities, haemodynamic disturbances and
their fluid and electrolyte balance corrected before
hypotension, convulsions, paralysis, coma,
contrast medium administration, administration into
rigors, ventricular fibrillation, pulmonary oedema, Anuria, coagulation defects, hypersensitivity to
subarachnoid space, brain metastases, congestive
Sodium and Meglumine Diatrizoate 58- Depend on the type of procedure and the degree and circulatory failure, cardiac arrest and diatrizoate, joint or disc infection
Urovison For IV pyelography heart failure, debilitated, diabetes with diabetic Diltiazem, metformin, propranolol
60% Injection extent of contrast required anaphylactoid or hypersensitivity reactions. (arthrography/discography), intrathecal
neuropathy, elderly patients, hepatic or biliary
Injection of diatrizoates into the central nervous procedures, splenoportography
disorder, hypertension, infants, convulsions, cerebral
system produces severe neurotoxicity. Acute
effects, acidosis and arrhythmias, multiple myeloma,
renal failure may follow intravenous
pheochromocytoma, pulmonary vascular beds, right
administration, particularly in dehydrated patients
ventricular failure, sensitivity to iodine or other
and patients with other predisposing factors.
contrast agent, sickle cell disease, subarachnoid
Pain at the injection site, extravasation may be
hemorrhage
followed by tissue damage, thrombophlebitis,
thrombosis, venospasm and embolism.
Fibrinolysis and possible depressant effect on
blood coagulation factors. The accidental
aspiration of solutions of these salts has caused
Excessive bicarbonate may lead to hypovolaemia
Major: sodium polystyrene sulfonate (systemic
and metabolic alkalosis in impaired renal function.
Alkalosis, hypernatremia, hypocalcaemia, alkalosis). Minor: amphetamine, aspirin,
i) Relief of discomfort in mild urinary tract ii) i) 3 g in every 2 hours until urinary pH exceeds 7 ii) History of congestive heart failure, history of renal Gastrointestinal cramps, flatulence, belching,
Sodium Bicarbonate 1 g/15 ml Mixture - hypochloraemia, severe pulmonary oedema, chlorpropamide, dextroamphetamine, ephedrine,
Alkalinisation of urine Maintenance of alkaline urine 5-10 g daily impairment, cirrhosis, hypertension, concurrent alkalosis on prolong use
unknown abdominal pain flecainide, itraconazole, ketoconazole, lithium,
corticosteroids, maintain high urine output, monitor
pseudoephedrine
acid-base balance and electrolytes
Amphetamine, aspirin, chlorpropamide,
For acceleration of excretion in drug intoxication (where Alkalosis, hypernatraemia, hypocalcaemia,
Sodium Bicarbonate 4.2% (0.5 IV infusion of 2 - 5 mmol/kg body weight over a period Renal impairment, peptic ulcer, congestive heart dextroamphetamine, ephedrine, itraconazole,
- excretion of the drug into the urine is accelerated by Gastrointestinal cramps, flatulence, alkalosis hypochloraemia, severe pulmonary oedema,
mmol/ml) Injection of 4 - 8 hours or according to the needs of the patients failure, oedema, cirrhosis ketoconazole, lithium, pseudoephedrine,
elevated urine pH) and for acidosis unknown abdominal pain
flecainide
Sodium Bicarbonate 5% w/v Ear
- To soften the impacted ear wax 2-3 drops 3-4 times daily Not known Contact dermatitis to sodium bicarbonate Not known Not known
Drops
Amphetamine, aspirin, chlorpropamide,
For acceleration of excretion in drug intoxication (where Alkalosis, hypernatraemia, hypocalcaemia,
Sodium Bicarbonate 8.4% (1 According to the needs of the patient. In severe shock Renal impairment, peptic ulcer, congestive heart dextroamphetamine, ephedrine, itraconazole,
- excretion of the drug into the urine is accelerated by Gastrointestinal cramps, flatulence, alkalosis hypochloraemia, severe pulmonary oedema,
mmol/ml) Injection due to cardiac arrest: 50 ml by IV failure, oedema, cirrhosis ketoconazole, lithium, pseudoephedrine,
elevated urine pH) and for acidosis unknown abdominal pain
flecainide
Excessive bicarbonate may lead to hypovolaemia
and metabolic alkalosis in impaired renal function. Major: sodium polystyrene sulfonate (systemic
Sodium Bicarbonate Mixture Mist Carminative CHILD up to 1 year 5 ml; up to 1-5 years 10 ml in 4 to 6 History of congestive heart failure, history of renal Gastrointestinal cramps, flatulence, belching, alkalosis). Minor: amphetamine, aspirin,
Heartburn for rapid relief of dyspepsia Alkalosis, hypocalcaemia, hypochloraemia
(Paediatric) Paed divided doses impairment, cirrhosis, hypertension, concurrent alkalosis on prolong use chlorpropamide, itraconazole, ketoconazole,
corticosteroids, maintain high urine output, monitor lithium, pseudoephedrine
acid-base balance and electrolyte
For relieving of discomfort in mild urinary tract infection,
Sodium Bicarbonate, Citric Acid, symptomatic relief of dysuria to enchance the action to
4 - 8 g (1- 2 sachets) dissolved in a glass of cold water Mild laxative effect, systemic alkalosis or
Sodium Citrate and Tartaric Acid - 4 g Ural certain antibiotics especially some sulphonamides. In Patients on sodium restricted diet Renal failure or hyperthermia Not known
4 times daily as prescribed hyperthermia with prolonged or excessive usage
per sachet gout as urinary alkalinizers to prevent cystallisation of
urates
Sodium Bicarbonate, Magnesium Tetracyclines, ketoconazole, itraconazole,
Gastrointestinal cramps, flatulence, belching,
Carbonate, Tincture Cardamom Carminative Heartburn, for rapid relief of dyspepsia ADULT 10-20 ml 3 times daily Renal impairment Hypersensitivity to antacids, hypophosphataemia dipyridamole, quinolones, captopril, lithium and
alkalosis on prolong use
Compound Mixture aspirin
Pregnancy, severe renal impairment, heart disease
Bowel cleansing before colonic surgery, colonoscopy Gastrointestinal obstruction, gastric retention,
(chronic cardiac failure, hypertension and oedema), Diuretics and drugs affect serum electroytes may
Sodium Biphosphate 16% & Sodium or radiological examination to ensure the bowel is free ADULT 133 ml (1 bottle) administered rectally. CHILD gastro-intestinal ulceration, perforated bowel,
Fleet enema ulcerative colitis (IBS) reflux oesophagitis, Local irritation and tenesmus induce hyperphosphataemia, hypocalaemia and
Phosphate 6% Enema of solid contents. It is not to be used for treatment of more than 2 years half the adult dose congestive cardiac failure, toxic colitis, toxic
preexisting electrolyte disturbances (low serum hypernatraemia
constipation megacolon or ileus
calcium concentration, hyperkalaemia)
45 ml diluted with half a glass (120 mL) of water,
followed by one full glass (240 mL) of water. Timing of
doses is dependent on the time of the procedure. For
Salts of magnesium, aluminium and calcium will
morning procedure, first dose should be taken at 7 a.m. Pregnancy, severe renal impairment, heart disease
Bowel cleansing before colonic surgery, colonoscopy Gastrointestinal obstruction, gastric retention, bind with phosphate and reduce the absorption.
and second at 7 p.m. on day before the procedure. For (chronic cardiac failure, hypertension and oedema),
Sodium Biphosphate 16%, Sodium or radiological examination to ensure the bowel is free Nausea, bloating, less frequently abdominal gastrointestinal ulceration, perforated bowel, Vitamin D will increase absorption of phosphate
Fleet solution afternoon procedure, first dose should be taken at 7 ulcerative colitis (IBS) reflux oesophagitis,
Phosphate 6% Solution of solid contents. It is not to be used for treatment of cramps and vomiting congestive cardiac failure, toxic colitis, toxic with diuretics and drugs affect serum electroytes
p.m. on day before and second dose at 7 a.m. on day preexisting electrolyte disturbances (low serum
constipation megacolon or ileus may induce hyperphosphataemia,
of the procedure. Solid food should not be taken during calcium concentration, hyperkalaemia)
hypocalcaemia and hypernatraemia
the bowel preparation period. However clear fluids or
water can be taken liberally. CHILD under 12 years not
recommended
Restrict intake in impaired renal function, cardiac
failure, hypertension, peripheral and pulmonary
oedema, toxaemia of pregnancy. Diabetes mellitus
hypersensitivity (ophthalmic products), sodium
For replenishing fluid and energy and for restoring or or carbohydrate intolerance and hyperglycaemia Thrombophlebitis, rebound hypoglycaemia,
Sodium Chloride 0.18% with Dextrose chloride solutions with preservatives in
- maintaining the concentration of sodium and chloride According to the needs of the patient may accentuate neurologic damage for an ischaemic hypokalaemia, sodium accumulation and Not known
10% Injection newborns, for injection or flushing of intravenous
ions insult. Patients at risk for cerebral ischaemia, acute oedema
lines or mixing medications, hypertonic saline
stroke, impending cardiac arrest or severe
abortifacient in pregnancies less than 15 weeks
hypotension unless hypoglycaemia is suggested or
until glucose is determined
4.23% Injection newborns, for injection or flushing of intravenous

Nausea, vomiting, diarrhoea, abdominal cramps,
Restrict intake in impaired renal function, cardiac congestive heart failure, hypertension,
For replenishing fluid and for restoring / maintaining the 100 - 1000 ml by IV or according to the needs of the chloride solutions with preservatives in
Sodium Chloride 0.45% Injection - failure, hypertension, peripheral and pulmonary tachycardia, fluid accumulation, irritability, Not known
concentration of sodium and chloride ions patient newborns, for injection or flushing of intravenous
oedema, toxaemia of pregnancy restlessness, weakness, headache, dizziness,
obtundation and convulsions

Sodium Chloride 0.9% Eye Drops Irrigation of conjunctival sac 1 - 2 drops every 3 - 4 hours Not known Can cause temporary burning and irritation Hypersensitivity Not known
Restrict intake in impaired renal function, cardiac congestive heart failure, hypertension,
For replenishing fluid and for restoring/maintaining the 100 - 1000 ml by IV or according to the needs of the chloride solutions with preservatives in
Sodium Chloride 0.9% Injection - failure, hypertension, peripheral and pulmonary tachycardia, fluid accumulation, irritability, Not known
concentration of sodium and chloride ions patient newborns, for injection or flushing of intravenous
oedema, toxaemia of pregnancy restlessness, weakness, headache, dizziness,
obtundation and convulsions


Addition of sodium electrolyte in parenteral nutrition Restrict intake in impaired renal function, cardiac congestive heart failure, hypertension, During therapy with corticosteroids or ACTH
chloride solutions with preservatives in
Sodium Chloride 20% Injection - bags especially in paediatrics or neonates with According to the needs of the patient failure, hypertension, peripheral and pulmonary tachycardia, fluid accumulation, irritability, there may be an increased retention of sodium
newborns, for injection or flushing of intravenous
restricted fluid allowance oedema, toxaemia of pregnancy restlessness, weakness, headache, dizziness, and chloride. Decreased levels of lithium
obtundation, convulsions

Restrict intake in impaired renal function, cardiac congestive heart failure, hypertension, During therapy with corticosteroids or ACTH
chloride solutions with preservatives in
Sodium Chloride 3% Injection - Acute dilutional hyponatraemia According to the needs of the patient failure, hypertension, peripheral and pulmonary tachycardia, fluid accumulation, irritability, there may be an increased retention of sodium
newborns, for injection or flushing of intravenous
oedema, toxaemia of pregnancy restlessness, weakness, headache, dizziness, and chloride. Decreased levels of lithium
obtundation, convulsion
Sodium Chromate (Chromium-51) Labelling of erythrocytes for the investigation of Usual dose range : 10 - 200 microcuries IV by IV
- Not known Not known Pregnancy and lactation Not known
Solution haemotological disorders injection
Dose depending on clinical cases. Usually, 30 ml given Renal tubular acidosis, chronic diarrhoea
Prophylaxis for aspiration pneumonitis (use as an oral Quinidine, antacids especially those containing
Sodium Citrate 0.3 M Solution - 10- 60 minutes before anaesthesia prior to elective syndromes, peripheral or pulmonary oedema, Metabolic alkalosis, hypernatraemia, diarrhoea Aluminium toxicity and heart failure
solution) aluminium or sodium bicarbonate
cesarean surgery is an effective antacid hypertension, toxaemia of pregnancy
Renal tubular acidosis, chronic diarrhoea
Sterile solution for irrigation or washout of infected Metabolic alkalosis, hypernatremia and Quinidine, antacids, especially those containing
Sodium Citrate 3.8% Solution - Dose depending on clinical cases syndromes, peripheral or pulmonary oedema, Aluminium toxicity and heart failure
bladder diarrhoea aluminium or sodium bicarbonate
hypertension, toxemia of pregnancy
Citrates and citric acid solutions are used to correct the Concurrent administration of potassium citrate
Congestive heart failure, hypertension, pulmonary or Severe renal impairment with oliguria, azotemia
acidosis of certain renal tubular disorders to treat with potassium- containing medications,
peripheral oedema, toxaemia of pregnancy, monitor or anuria, Addison's disease, acute dehydration,
Sodium Citrate, Citric Acid Mixture 3 metabolic acidosis for long-term urine alkalinization for ADULT 10 - 20 ml. CHILD up to 1 year 2.5 ml; 6-12 Hyperkalaemia, metabolic alkalosis, nausea, angiotensin-converting enzyme inhibitors or
Mist Sod Citrate serum electrolytes, especially bicarbonate in patients heat cramps, severe myocardial damage.
g/10 ml prevention and treatment of uric acid and calcium years 10 ml. To be taken well diluted with water vomiting, diarrhoea cardiac glycosides, concurrent administration
with renal disease, decreased urinary output, Potassium citrate in patients with hyperkalaemia.
kidney stones and as nonparticulate neutralizing with aluminum-based gels, blood products
especially in the presence of hypocalcaemia Sodium citrate for patients on sodium restriction
buffers containing citrate
Prevention and treatment of allergic conjunctivitis Transient stinging and burning may occur after Patients with known hypersensitivity to sodium
Pregnancy, lactation, children up to 4 years of age,
Sodium Cromoglycate 2% Eye Drops Opticrom including seasonal and perennial allergic conjunctivitis 1 or 2 drops 4 times daily instillation and other symptoms of local irritation, cromoglycate or any other ingredient of the Not known
elderly
and vernal keratoconjunctivitis itching, redness and severe swelling of the eyes products
Acids, alkalis and reducing agents. Solid reacts
with nitrogen compounds including ammonia and
Sodium Dichloroisocyanurate 2.5 g Irritation on eyes, dermatitis, lung damage, skin Avoid contact between solid and acid, ammonia,
Presept Low and medium level disinfectant 50 - 10,000 ppm av chlorine Avoid contact with skin and eyes urea. For solid avoid contact with combustible
Tablet burns, ulceration, itching urea and reducing agents
organic materials such as paper, wood and
textiles
Acids, alkalis and reducing agents. Solid reacts
with nitrogen compounds including ammonia and
Sodium Dichloroisocyanurate 5 g Irritation on eyes, dermatitis, lung damage, skin Avoid contact between solid and acid, ammonia,
Presept Low and medium level disinfectant 50 - 10,000 ppm av chlorine Avoid contact with skin and eyes urea. For solid avoid contact with combustible
Tablet burns, ulceration, itching urea and reducing agents
organic materials such as paper, wood and
textiles
Skin infections caused by staphylococci, streptococci,
Avoid contact with eyes and other mucous Infection caused by non-susceptable organism in
Sodium Fusidate 2% Ointment Fucidin corynebacterium minutissumun and other sodium Apply to affected area 2 - 3 times daily Rash, irritation, pruritus, contact dermatitis Not known
membranes particular pseudomonas aeruginosa
fusidate-sensitive organisms
Dissolves blood clots, delays clotting. Higher
For external use only, avoid eye or mucous Hypersensitivity to any component of the
Sodium Hypochlorite Solution Milton, Clorox Low-level disinfectant and antiseptic Antiseptic: less than 0.5%. Disinfectant: 5% concentration-corrosive to the eye, the skin and Not known
membrane contact, do not use on open wounds formulation
respiratory tract
There may be severe and potentially dangerous
swelling of thyroid in patient with large goitres and Hypothyroid, hypoparathyroid, thyroiditis,
Pregnancy or who may become pregnant,
Sodium Iodide (Iodide-131) Injection has produced asphyxiation. Not recommended for leukaemia, thyroid cancer, sialoadenitis, thyroid
Used in the determination of various thyroid functions 5 - 50 millicuries lactation, large toxic nodular goitres, severe Antihistamines
(Diagnostic) hyperthyroidism treatment in patients under 30 storm, gastritis, nausea, vomiting, bone marrow
thyrotoxic heart disease, vomiting, diarrhoea
years, prior use of iodine, thyroid or anti-thyroid suppression
drugs, radiopharmaceutical, handle with care
Sodium Iodide (Iodine-131) Capsule has produced asphyxiation. Not recommended for leukaemia, thyroid cancer, sialoadenitis, thyroid
Determination of various thyroid functions 5 - 10 milicuries (5 mCi for whole body scan) lactation, large toxic nodular goitres, severe Antihistamines
(Diagnostic) hyperthyroidism treatment in patients under 30 storm, gastritis, nausea, vomiting, bone marrow
Sodium Iodide (Iodine-131) Capsule has produced asphyxiation. Not recommended for leukaemia, thyroid cancer, sialoadenitis, thyroid
- i) Thyrotoxicosis ii) Thyroid carcinoma i) 2 - 30 millicuries ii) 80 - 300 millicuries lactation, large toxic nodular goitres, severe Antihistamines
(Therapeutic) hyperthyroidism treatment in patients under 30 storm, gastritis, nausea, vomiting, bone marrow
drugs, radiopharmaceutical. To be handle with care
has produced asphyxiation. Not recommended for leukaemia, thyroid cancer, sialoadenitis, thyroid
Sodium Iodide (Iodine-131) Solution i) Thyrotoxicosis ii) Thyroid carcinoma i) 5-25 millicuries ii) 30-150 millicuries lactation, large toxic nodular goitres, severe Antihistamines
hyperthyroidism treatment in patients under 30 storm, gastritis, nausea, vomiting, bone marrow
Metabolic or respiratory alkalosis, congestive heart
failure, other sodium-retaining conditions, concurrent Anxiety, panic attacks, apprehension or fear, Lactic acidosis, severe acidosis, hypernatraemia
Sodium Lactate Compound Replacement of extracellular losses of fluid and 100-1000 ml by IV or according to the needs of the
- corticosteroids, conditions impairing lactate paraesthesias, tremors, dizziness, metabolic and conditions where sodium administration Not known
(Hartmanns Solution/Ringer-lactate] electrolytes, as an alkaliniser agent patient
utilisation (severe hepatic insufficiency, shock, alkalosis, hypokalaemia would be detrimental
beriberi, hypoxia) and during prolonged therapy
Nausea, vomiting, abdominal pain, dizziness,
300 mg IV over 3 minutes followed after 5 minutes with headache, flushing, cyanosis, tachypnoea,
50 ml sodium thiosulphate 50% injection administered dyspnoea, vasodilatation resulting in syncope,
Sodium Nitrite 30 mg/ml Injection - For cyanide poisoning Not known Not known Not known
over 10 minutes. CHILD: 4.5 - 10 mg/kg followed by hypotension and tachycardia. Overdosage may
1.65 ml/kg of 25% sodium thiosulphate injection result in cardiovascular collapse, coma,
convulsions and death
Excessive hypotension, acute heart failure
i) By IV infusion, initially 0.5-1.5 mcg/kg/min, then
associated with reduced peripheral vascular Tachycardia, postural hypotension, nausea,
adjusted before increasement of 0.5 mcg/kg/min every
resistance. Cyanide toxicity, methaemoglobinemia, retching, diaphoresis, apprehension, headache, Hypotensive effect potentiated by ganglion
i) Hypertensive crisis ii) Controlled hypotension during 5 mins within range 0.5-8 mcg/kg/min (lower doses in
Sodium Nitroprusside 50 mg/5 ml NADH-methaemoglobin reductase deficiency, drug- restlessness, muscle twitching, retrosternal Hypersensitivity to nitroprusside, head trauma, blockers, other antihypertensive agents, volatile
Nipride anaesthesia in order to reduce bleeding in surgical patients already receiving other antihypertensives);
Injection induced (phenacetin, nitrites, nitrates, sulfonamides, discomfort, palpitation, perspiration, dizziness, symptomatic hypotension, encephalopathy liquid anaesthetics and other circulatory
procedures stop if marked response not obtained with max dose in
dapsone, chlorates, chloroquine, primaquine and drowsiness, paraesthesial warmth, abdominal depressants
10 minutes. Use only in infusion with 5 % Dextrose IV.
phenazopyridine). Pre-existing anaemia and or pain. Irritation and reddening at injection site
ii) By IV infusion, max: 1.5 mcg/kg/min
hypovolaemia
Pregnancy and lactation, sequential therapy with
a chemotherapeutic agent, treatment of bone
metastases when leukocyte count is less than
Intracavitary administration should not be utilized,
Polycythemia vera, chronic myeloid and chronic Initially 5 millicuries, follow if necessary by a dose of not 5,000/mm and platelet count is less than
Sodium Phosphate (Phosphorus-32) overdose, potential for serious hemopoietic effects,
- lymphocytic leukaemia and palliative treatment of bone more than 3 or 4 millicurie at intervals of not less than 2 Not known 100,000/mm, treatment of chronic myelocytic Not known
Injection monitoring required, radiation, minimize exposure to
metastases months leukaemia when leukocyte count is less than
patients and healthcare personnel
20,000/mm, treatment of polycythemia vera
when leukocyte count is less than 5,000/mm or
platelet count is less than 15,000/mm
Renal failure and with conditions requiring a In patients with plasma potassium levels below 5
ADULT : Oral : 15 g 1 - 4 times/day. Rectal : 30 g in 100 restricted sodium intake, such as heart failure and mmol/litre, history of hypersensitivity to Magnesium-containing laxatives, aluminum
For hyperkalaemia associated with anuria or severe ml 2% methylcellulose and 100 ml water as a daily severe hypertension, calcium polystyrene Anorexia, nausea, vomiting, constipation, gastric polystyrene sulphonate resins, obstructive bowel carbonate, aluminum hydroxide, aluminum
Sodium Polystyrene Sulphonate
Resonium-A oliguria, in dialysis patients or those on prolonged retention enema. Retain for 9 hours followed by non- sulphonate may be preferred in these patients. irritation and occasionally diarrhoea. disease. Resonium A should not be administered phosphate. Calcium : increased risk of metabolic
Powder
peritoneal dialysis sodium cleansing enema. CHILD : 1 g/kg in 1 - 4 doses Hypokalaemia, other electrolyte disturbances, Constipation may be severe orally to neonates and is contraindicated in alkalosis. Levothyroxine : hypothyroidism.
in acute hyperkalemia. Maintenance : 0.5 g/kg/daily constipation, children and neonates, patients at risk neonates with reduced gut motility (post- Sorbitol, digitalis-like drugs, lithium
from an increase in sodium load operatively or drug-induced)
0.5-2 mL into the submucosal layer at the base of the Pain, urticaria and ulceration at the site of
Sodium Tetradecyl Sulphate 1 % Sclerotherapy of oesophageal varices, haemorrhoids oesophageal varix or the haemorrhoid; several injection, embolisms, headache, nausea, Large or inaccessible varicose veins, febrile
Trombovar Patients with history of allergy, pregnancy, lactation Not known
Injection and varicose veins injections may be given at different sites, max. total vomiting, esophageal perforation, allergic illness, phlebitis
injected 10-15 mL of 1% per treatment reactions (including anaphylaxis)
0.5-2 mL into the submucosal layer at the base of the Pain, urticaria and ulceration at the site of
Sodium Tetradecyl Sulphate 3 % Sclerotherapy of oesophageal varices, haemorrhoids oesophageal varix or the haemorrhoid, several injection, embolisms, headache, nausea, Large or inaccessible varicose veins, febrile
Trombovar Patients with history of allergy, pregnancy, lactation Not known
Injection and varicose veins injections may be given at different sites, max. total vomiting, esophageal perforation, allergic illness, phlebitis
injected 10-15 mL of 1% per treatment reactions (including anaphylaxis)
Hypotension, coma, psychosis, confusion,
Apply to all affected parts of the body and face with a Discontinue topical use if irritation or sensitivity
Sodium Thiosulphate 10-20% contact dermatitis, local irritation, neuromuscular Hypersensitivity to sodium thiosulphate or any
- Fungicides. For the treatment of pityriasis versicolor brush after a bath once daily or twice daily or 3 times occurs, rapid IV infusion has caused transient Not known
Solution and skeletal weakness, tinnitus, diarrhoea component of the formulation
daily hypotension
(following large accidental ingestion)
ADULT : 300 mg sodium nitrite IV over 3 minutes

followed after 5 minutes with 50 ml sodium thiosulphate
Sodium Thiosulphate 500 mg/ml Too rapid intravenous administration has caused
- For cyanide poisoning 50% injection administered over 10 minutes. CHILD : Diarrhoea, allergic contact dermatitis Not known Not known
Injection hypotension
4.5 - 10 mg/kg sodium nitrite IV followed by 1.65 ml/kg
of 25% sodium thiosulphate injection
Increases phenobarbital, primidone and
ADULT: Initially 600 mg/day in 2 - 3 divided doses, Monitor liver function, avoid sudden withdrawal, phenytoin plasma concentrations. Potentiates
dose may be increased by 200 mg at 3-day intervals to certain metabolic disorders, fatigue, loss of appetite, toxic effect of carbamazepine. Risk of rash may
max 2.5 g/day. Usual maintenance dose: 1-2 g/day (20- vomiting. Pregnancy and lactation. Avoid be increased by coadministration with
Nausea, vomiting, headache, dizziness, ataxia,
30 mg/kg/day). CHILD: More than 20 kg. Initially 400 concomitant use of salicylates in children less than 3 Hepatic disease or significant hepatic lamotrigine. May potentiate the effect of
tremor, weight gain, transient hair loss, oedema,
Sodium Valproate 200 mg Tablet Epilim Epilepsy mg/day with spaced increases until control is achieved years due to risk of liver toxicity, use of salicylates in dysfunction, hypersensitivity to valproate sodium, neuroleptics, MAOIs, antidepressants and
thrombocytopenia, leukopenia. Liver dysfunction,
(usually 20-30 mg/kg/day), dose may be increased to children less than 16 years is also not valproic acid or divalproex sodium, porphyria benzodiazepines. Potentiate effects of MAOIs.
gastrointestinal disorders
35 mg/kg/day. Less than 20 kg 20 mg/kg/day, in severe recommended. Monitor liver function before therapy Monitor prothrombin time when used with
cases the dose may be increased provided plasma and during first 6 months. Potential for an increase in anticoagulants. Caution when used with newer
concentration can be monitored risk of suicidal thoughts or behaviours anti-epileptics whose pharmacodynamics are not
well-established
Monitor liver function, avoid sudden withdrawal,
phenytoin plasma concentrations. Potentiates
certain metabolic disorders, fatigue, loss of appetite,
Nausea, vomiting, headache, dizziness, ataxia, toxic effect of carbamazepine. Risk of rash may
CHILD: More than 20 kg. Initially 400 mg/day with vomiting. Pregnancy, lactation, Avoid concomitant
tremor, weight gain, transient hair loss, oedema, be increased by coadministration with
spaced increases until control is achieved (usually 20- use of salicylates in children less than 3 years due to Hepatic disease or significant hepatic
thrombocytopenia (dose related), leukopenia. lamotrigine. May potentiate the effect of
Sodium Valproate 200 mg/5 ml Syrup Epilim Epilepsy 30 mg/kg/day), dose may be increased to 35 risk of liver toxicity, use of salicylates in children less dysfunction, hypersensitivity to valproate sodium,
Gastrointestinal disorders, liver failure, children neuroleptics, MAOIs, antidepressants and
mg/kg/day. Less than 20 kg, 20 mg/kg/day. Severe than 16 years is also not recommended. Monitor valproic acid or divalproex sodium, porphyria
under the age of two years are at increased risk, benzodiazepines. Monitor prothrombin time
cases: 50 mg/kg daily liver function before therapy and during first 6
pancreatitis when used with anticoagulants. Caution when
months. Potential for an increase in risk of suicidal
used with newer anti-epileptics whose
thoughts or behaviours
pharmacodynamics are not well-established
Monitor liver function, avoid sudden withdrawal, phenytoin plasma concentrations. Potentiates
certain metabolic disorders, fatigue, loss of appetite, toxic effect of carbamazepine. Risk of rash may
vomiting. Pregnancy, lactation. Avoid concomitant be increased by coadministration with
ADULT and CHILD above 10 years: 10 to 15 mg/kg/day Nausea, vomiting, headache, dizziness, ataxia,
use of salicylates in children less than 3 years due to Hepatic disease or significant hepatic lamotrigine. May potentiate the effect of
IV, may increase 5 to 10 mg/kg/week to achieve optimal tremor, weight gain, transient hair loss, oedema,
Sodium Valproate 400 mg Injection Epilim Status epilepticus risk of liver toxicity, use of salicylates in children less dysfunction, hypersensitivity to valproate sodium, neuroleptics, MAOIs, antidepressants and
clinical response (Maximum 60 mg/kg/day or less with thrombocytopenia, leukopenia. Liver dysfunction,
than 16 years is also not recommended. Monitor valproic acid or divalproex sodium, porphyria benzodiazepines. Potentiate effects of MAOIs.
a therapeutic range of 50 to 100 mcg/mL) gastrointestinal disorders
liver function before therapy and during first 6 Monitor prothrombin time when used with
months. Potential for an increase in risk of suicidal anticoagulants. Caution when used with newer
thoughts or behaviours anti-epileptics whose pharmacodynamics are not
well-established
Patients with growth hormone deficiency secondary
to an intracranial lesion should be examined
frequently for progression or recurrence of the Injection site reactions, hypersensitivity
underlying disease. Appearance of hypothyroidism reactions. Patient in whom short stature is due to
Children with epiphyseal fusion. Active
i) Growth failure due to inadequate endogenous growth in the course of therapy with somatropin should be a genetic defect, treatment with somatropin may
i) 0.7-1 mg/m2/day or 0.025-0.035 mg/kg/day SC/IM ii) neoplasia, progression or recurrence of
hormone ii) Growth failure in girls due to gonadal corrected with thyroid hormone in order to obtain a induce development of growth-attenuating Concomitant corticosteroid therapy may inhibit
Somatropin 12 mg (36IU) Injection 1.4 mg/m2/day or 0.045-0.05 mg/kg/day SC iii) 0.035 underlying intracranial lesion, critically ill patient,
dysgenesis (Turner syndrome) iii) Growth failure in sufficient growth promoting effect. Intra- or antibodies. Epiphysiolysis of hip joint in children the effect of somatropin
mg/kg/day or 1 mg/m2/day SC proliferative or pre-proliferative diabetic
short children born small gestational age (SGA) extracranial neoplasia in remission. Diabetes receiving growth hormone therapy. Adult
retinopathy
Mellitus. Slipped capital femoral epiphyses may receiving growth hormone replacement therapy:
occur more frequently in patients with endocrine Oedema, muscle and joint pain, joint disorders
disorders including growth hormone deficiency.
Pregnancy and lactation
Somatropin 5mg (15IU) Injection Norditropin 1.4 mg/m2/day or 0.045-0.05 mg/kg/day SC iii) 0.035 underlying intracranial lesion, critically ill patient,
retinopathy
Somatropin 8 mg (24IU) Injection Saizen 1.4 mg/m2/day or 0.045-0.05 mg/kg/day SC iii) 0.035 underlying intracranial lesion, critically ill patient,
retinopathy
Avoid abrupt withdrawal, gradual withdrawal over a
period of 1 to 2 weeks is recommended.
Bronchospastic disease, concomitant use with other
drugs that prolong the QT interval, congestive heart
Hypersensitivity to sotalol products, asthma,
failure (doses of 3 milligrams/kg or greater should May potentiate initial insulin hypoglycaemic
Dyspnoea, tiredness, dizziness, headache, bradycardia, 2nd and 3rd degree AV block overt
Sotalol HCl 160 mg Tablet Sotacor Ventricular tachyarrythmias 80 - 320 mg twice daily not be administered by bolus infusion), diabetes effects. Affected by class I antiarrhythmics,
fever, excessive bradycardia and or hypotension cardiac failure, cardiogenic shock, congenital or
mellitus, electrolyte imbalance (ie: hypokalaemia, quinidine, disopyramide, tricyclic antidepressants
acquired long QT syndromes
hypomagnesemia), hyperthyroidism/thyrotoxicosis,
peripheral vascular disease, renal disease,
underlying conduction disturbances (eg, sick sinus
syndrome)
Avoid abrupt withdrawal, gradual withdrawal over a
period of 1 to 2 weeks is recommended.
Bronchospastic disease, concomitant use with other
drugs that prolong the QT interval, congestive heart
Hypersensitivity to sotalol products, asthma,
failure (doses of 3 milligrams/kg or greater should May potentiate initial insulin hypoglycaemic
Dyspnoea, tiredness, dizziness, headache, bradycardia, 2nd and 3rd degree AV block overt
Sotalol HCl 80 mg Tablet Sotacor Ventricular tachyarrythmias 80 - 320 mg twice daily not be administered by bolus infusion), diabetes effects. Affected by class I antiarrhythmics,
fever, excessive bradycardia and or hypotension cardiac failure, cardiogenic shock, congenital or
mellitus, electrolyte imbalance (ie: hypokalaemia, quinidine, disopyramide, tricyclic antidepressants
acquired long QT syndromes
hypomagnesemia), hyperthyroidism/thyrotoxicosis,
peripheral vascular disease, renal disease,
underlying conduction disturbances (eg, sick sinus
syndrome)
Angiotensin converting enzyme inhibitors,
Headache, drowsiness, gastrointestinal
ciclosporin: hyperkalaemia. Aspirin: decreased
ADULT: 100 - 200 mg daily in divided doses. Increase Hyperkalaemia or progressive renal failure, impaired disturbances including cramp and diarrhoea, Hypersensitivity, hyperkalaemia, renal failure,
Oedema and ascites in cirrhosis of the liver, congestive spironolactone effectiveness. Digoxin: digoxin
Spironolactone 25 mg Tablet Aldactone to 400 mg if required. CHILD: initially 3 mg/kg daily in hepatic or renal function, diabetes mellitus, patients ataxia, mental confusion, hirsutism, deepening of anuria, patients receiving other potassium-
heart failure toxicity (nausea, vomiting, cardiac arrhythmias).
divided doses likely to develop acidosis. Pregnancy and lactation the voice, menstrual irregularities, impotence, sparing diuretics or potassium supplements
NSAIDs: reduced diuretic effectiveness,
skin rashes, hyponatraemia, hyperkalaemia
hyperkalaemia
Headache, rash, gastrointestinal effects,
peripheral neuropathy, abdominal pain, allergic
reaction, anaemia, anorexia, chills, diabetes
NEONATES 0 - 13 days old: 0.5 mg/kg/dose twice
mellitus, fever, hepatic failure, hepatitis,
daily. CHILD 14 days and older and weighing less than Pregnancy, lactation, history of peripheral
Stavudine 1 mg/ml Solution Zerit HIV infection, in combination with other antiretrovirals hepatomegaly, hyperglycaemia, hyperlactatemia, Hypersensitivity to stavudine Zidovudine, doxorubicin, ribavirin, didanosine
30 kg: 1 mg/kg twice daily; more than 30 kg: 30 mg neuropathy
insomnia, lactic acidosis, leukopenia,
twice daily
macrocytosis, motor weakness, myalgia,
pancreatitis, redistribution /accumulation of body
fat, thrombocytopenia
ADULT more than 60 kg: 40 mg twice daily; less than mellitus, fever, hepatic failure, hepatitis,
Renal and hepatic impairment, peripheral
Stavudine 30 mg Capsule Zerit HIV infection, in combination with other antiretrovirals 60 kg: 30 mg twice daily. CHILD more than 30 kg: 30 hepatomegaly, hyperglycaemia, hyperlactatemia, Hypersensitivity to stavudine Zidovudine, doxorubicin, ribavirin, didanosine
neuropathy, elderly, pregnancy and lactation
mg twice daily; less than 30 kg: 15 mg twice daily insomnia, lactic acidosis, leukopenia,
Peripheral neuropathy, pancreatitis, chills, fever,

malaise, diarrhoea, constipation, dyspepsia,
asthenia, anorexia, nausea/vomiting, chest,
Fixed dose triple therapy for treatment of HIV infection Hepatitis B or C. Discontinue immediately if severe abdominal and back pain, depression, anxiety, Patients who are just initiating therapy with
in adults once patients have been stabilized on the life-threatening skin reactions occur and do not flu syndrome, sweating, dizziness, dyspnoea, nevirapine. These patients require a lead-in dose Trimethoprim and sulphamethoxazole,
Stavudine 30 mg, Lamivudine 150 mg One tablet twice daily for patients weighing less than 60
SLN 30 maintenance regimen of nevirapine 200 mg twice daily rechallenge. Avoid concomitant prednisone. Perform rash, pruritus. Stevens-Johnson syndrome, toxic of nevirapine 200 mg daily, whereas this rifampicin, ketoconazole, oral contraceptives,
& Nevirapine 200 mg Tablet kg
and have demonstrated adequate tolerability to baseline and periodic liver function tests. Pregnancy epidermal necrolysis, serious hepatitis, hepatic formulation contains the maintenance dose of methadone
nevirapine and lactation failure, hypersensitivity reactions characterised nevirapine 200 mg twice daily
by rash with constitutional symptoms and
visceral involvement, gastrointestinal
disturbances, fatigue, somnolence, myalgia
ADULT more than 60 kg: 40 mg twice daily; less than mellitus, fever, hepatic failure, hepatitis,
Renal and hepatic impairment, peripheral
Stavudine 40 mg Capsule Zerit HIV infection, in combination with other antiretrovirals 60 kg: 30 mg twice daily. CHILD more than 30 kg: 30 hepatomegaly, hyperglycaemia, hyperlactatemia, Hypersensitivity to stavudine Zidovudine, doxorubicin, ribavirin, didanosine
neuropathy, elderly, pregnancy and lactation
mg twice daily; less than 30 kg: 15 mg twice daily insomnia, lactic acidosis, leukopenia,
Peripheral neuropathy, pancreatitis, chills, fever,
malaise, diarrhoea, constipation, dyspepsia,
asthenia, anorexia, nausea/vomiting, chest,
Fixed dose triple therapy for treatment of HIV infection Hepatitis B or C. Discontinue immediately if severe abdominal and back pain, depression, anxiety, Patients who are just initiating therapy with
in adults once patients have been stabilized on the life-threatening skin reactions occur and do not flu syndrome, sweating, dizziness, dyspnoea, nevirapine. These patients require a lead-in dose Trimethoprim and sulphamethoxazole,
Stavudine 40 mg, Lamivudine 150 mg One tablet twice daily for patients weighing less than 60
SLN 40 maintenance regimen of nevirapine 200 mg twice daily rechallenge. Avoid concomitant prednisone. Perform rash, pruritus. Stevens-Johnson syndrome, toxic of nevirapine 200 mg daily, whereas this rifampicin, ketoconazole, oral contraceptives,
& Nevirapine 200 mg Tablet kg
and have demonstrated adequate tolerability to baseline and periodic liver function tests. Pregnancy epidermal necrolysis, serious hepatitis, hepatic formulation contains the maintenance dose of methadone
nevirapine and lactation failure, hypersensitivity reactions characterised nevirapine 200 mg twice daily
by rash with constitutional symptoms and
visceral involvement, gastrointestinal
disturbances, fatigue, somnolence, myalgia
Arterial invasive procedures should be avoided
before and during treatment and invasive venous
procedures should be performed carefully.
Spontaneous bleeding from internal sites may occur. Hypersensitivity to streptokinase products,
Myocardial infarction: 1,500,000 units over 30 - 60
Concurrent use of anticoagulants with streptokinase streptococcal infections within 6 months
minutes. Pulmonary embolism: 250,000 units by IV Nausea, vomiting, bleeding, reperfusion
Streptokinase 1,500,000 IU Injection Streptase Acute myocardial infarction, acute pulmonary embolism is not recommended. Concurrent use of heparin may haemorrhage, cardiovascular arrest, surgery or Aspirin, dipyridamole, eptifibatide, warfarin
infusion over 30 minutes, then 100,000 units every hour arrhythmias, hypotension, bronchospasm
be required during intracoronary administration of trauma within 1 month, subacute bacterial
for up to 12-72 hours with monitoring of clotting factors
streptokinase. Precaution must be taken during endocarditis
concurrent use of drugs that may alter platelet
function (dextran, aspirin, indomethacin,
phenylbutazone) and anticoagulants
Used with blood substitutes and diuretics
0.5 - 1 g IM of Streptomycin base daily or at longer Renal and hepatic impairment. Elderly, poor oral and Ototoxicity, nephrotoxicity, shock, vitamin K and intensify nephrotoxicity and ototoxicity. Possible
Streptomycin Sulphate 1 g Injection - Tuberculosis Hypersensitivity to other aminoglycosides
intervals, cumulative dose should not exceed 100 g parenteral nutrition. Pregnancy and lactation vitamin B deficiency, Steven-Johnson syndrome inhibition of respiration with anaesthetics or
muscle relaxants
Continuation of treatment in patients developing Food, milk and derivative products, medicinal
Nausea, diarrhoea, headache, disturbances in
severe renal impairment should be considered on an products containing calcium, administration of
Treatment of postmenopausal osteoporosis to reduce consciousness, memory loss, dermatitis,
individual basis, caution in patients at increased risk Hypersensitivity to strontium ranelate or to any of aluminium and magnesium hydroxides. Oral
Strontium Ranelate 2 g Granules Protaxos® risk of vertebral and hip fractures when 2 g sachet once daily eczema, seizures, increased annual incidence of
of venous thromboembolism (VTE), contains a the excipients tetracycline and quinolone antibiotics. Strontium
biphosphonates are contraindicated or not tolerated venous thromboembolism, transient emergent
source of phenylalanine which may be harmful for ranelate treatment should be suspended during
increases in creatinine kinase (CK) activity
people with phenylketonuria treatment with these antibiotics
Possible risk of irreversible effects through
Succindialdehyde 11% & High level disinfection for endoscopes, Immersion time is based on manufacturers Avoid eye and skin contact. Advice to wear personal inhalation, in contact with skin and if swallowed.
Hypersenstivity to any of its component Not known
Dimethoxytetrahydrofuran 3% ultrasonicprobes, anaesthesia equipment etc recommendation protective equipment (PPE) Risk of serious damage to eye. Vapours may
cause drowsiness and dizziness
Reduced the extent of absorption
i) 2 g twice daily or 1 g 4 times daily for 4-6 weeks or in Chronic renal failure and on dialysis (avoid if Constipation, diarrhoea, nausea, gastric
(bioavailability). Fluoroquinolones, tetracycline,
i) Benign gastric and duodenal ulceration ii) Stress resistant cases up to 12 weeks (maximum 8 g daily) ii) severe), pregnancy, breast feeding. Administration discomfort, indigestion, dry mouth, drowsiness,
Sucralfate 1 g Tablet - Hypersensitivity to sucralfate products warfarin, phenytoin, ketoconazole, lansoprazole,
ulcer prophylaxis 1 g 6 times daily (maximum 8 g daily). CHILD not of sucralfate and enteral feeds should be separated dizziness, skin rash, hypersensitive reaction
digoxin, ranitidine, cimetidine, theophylline and
recommended by 1 hour dosing including pruritus, back pain, vertigo
levothyroxine
Discontinue if skin reactions occur. Avoid excessive Rash, pruritus, contact dermatitis, urticaria,
Treatment of Plasmodium falciparum malaria in Treatment as single dose. ADULT : 2 - 3 tablet. CHILD exposure to sunlight. Analysis for crystalluria during nausea and feeling of fullness, headache. Hypersensitivity to sulfonamides. Premature or
Sulfadoxine 500 mg and patients in whom chloroquine resistance is suspected more than 45 kg : 3 tablets, 45 to 31 kg : 2 tablets, 30 to prolonged prophylaxis therapy is recommended, Rarely, Steven-Johnson and Lyell's syndromes, newborn infants, pregnancy, prophylactic Methotrexate, sulfamethoxsazole, trimethoprim,
Fansidar
Pyrimethamine 25 mg Tablet and malaria prophylaxis for travellers to areas where 21 kg : 1 and half tablets, 20 to 11 kg : 1 tablet, 5 to 10 impaired renal or hepatic function, periodic blood blood dyscrasias, liver cell damage, (prolonged) use in patients with renal/hepatic zidovudine, lorazepam
chloroquine-resistant malaria is endemic kg : one-half tablet counts are recommended, possible folate deficiency, agranulocytosis, aplastic anaemia, failure and with blood dyscrasias
severe allergic or bronchial asthma thrombocytopenia, hepatitis, nephrotoxicity
Tearing, stinging, burning, headache, bitter taste,
1-2 drops into conjunctival sac(s) of affected eye(s) Patients with dry-eye syndrome. Some ophthalmic
hypersensitivity reactions, Stevens-Johnson
Non-purulent blepharitis, blepharo-conjunctivitis, non- every 2 - 3 hour initially; taper by increasing time sulfacetamide preparations contains sulfites, which Hypersensitivity to sulfacetamide or other
Sulphacetamide 10% Eye Drops - syndrome. Corneal plaques (sulfacetamide Pilocarpine
purulent conjunctivitis intervals as condition responds. Usual duration 7-10 may induced hypersensitivity reactions in sulfonamides
crystallization) in patients with dry-eye
days susceptible individuals
syndrome, eye lid edema
Gastrointestinal upsets, stomatitis, glossitis and Increased risk of thrombocytopenia with thiazide
CHILD less than 12 years: Trimethoprim 6 mg &
skin rashes, tinnitus, erythema multiforme, Marked liver parenchymal damage, blood diuretics in elderly. May require dosage
Sulphamethoxazole 30 mg/kg/day, divided into 2 equal Haematological disorders, elderly, pregnancy,
Sulphamethoxazole 200 mg & Stevens-Johnson syndrome, Lyell's syndrome, dyscrasias, severe renal impairment, pregnancy, reduction of warfarin and phenytoin. May
Bactrim Infections caused by susceptible pathogens doses. CHILD more than 12 years: Standard dose: 10 lactation, G6PD deficiency, folate deficiency,
Trimethoprim 40 mg/5ml Suspension leucopenia, neutropenia, thrombocytopenia, hypersensitivity. Use with caution in premature displace methotrexate from plasma protein
ml diluted and infused twice daily. Severe infections: 15 impaired renal function
agranulocytosis, megaloblastic anaemia, babies or full-term infants in the neonatal period binding sites. Increased risk of venticular
ml diluted and infused twice daily
pancytopenia or purpura, hyperkalaemia arrhythmias with amiodarone
i) ADULT: 960 mg twice daily increased to 1.44 g twice

daily in severe infections. CHILD: 36 mg/kg daily in 2
divided doses increased to 54 mg/kg/day in severe
Gastrointestinal upsets, stomatitis, glossitis and Increased risk of thrombocytopenia with thiazide
infections ii) Treatment: ADULT & CHILD over 4 weeks:
i) Severe or complicated infections when oral therapy is skin rashes, tinnitus, erythema multiforme, Marked liver parenchymal damage, blood diuretics in elderly. May require dosage
120 mg/kg/day PO/IV infusion in 2 - 4 divided doses for Haematological disorders, elderly, pregnancy,
Sulphamethoxazole 400 mg & not feasible ii) Treatment and prophylaxis of Stevens-Johnson syndrome, Lyell's syndrome, dyscrasias, severe renal impairment, pregnancy, reduction of warfarin and phenytoin. May
Bactrim 14 days. Prophylaxis: ADULT: 960 mg once daily or lactation, G6PD deficiency, folate deficiency,
Trimethoprim 80 mg Injection pneumocystis carinii pneumonia (PCP) in leucopenia, neutropenia, thrombocytopenia, hypersensitivity. Use with caution in premature displace methotrexate from plasma protein
960 mg on alternate days (3 times a week) or 960 mg impaired renal function
immunocompromised patients agranulocytosis, megaloblastic anaemia, babies or full-term infants in the neonatal period binding sites. Increased risk of venticular
twice daily on alternate days (3 times a week). CHILD 6
pancytopenia or purpura, hyperkalaemia arrhythmias with amiodarone
weeks - 5 months: 120 mg twice daily on 3 consecutive
days or 7 days per week; 6 months - 5 years: 240 mg; 6
- 12 years: 480 mg
i) ADULT: 1 - 3 tablets twice daily ii) Treatment: ADULT
& CHILD over 4 weeks: 120 mg/kg/day in 2 - 4 divided Gastrointestinal upsets, stomatitis, glossitis and Increased risk of thrombocytopenia with thiazide
i) Severe or complicated infections due to susceptible doses for 14 days. Prophylaxis: ADULT: 960 mg once skin rashes, tinnitus, erythema multiforme, Marked liver parenchymal damage, blood diuretics in elderly. May require dosage
Haematological disorders, elderly, pregnancy,
Sulphamethoxazole 400 mg & infection ii) Treatment and prophylaxis of pneumocystis daily or 960 mg on alternate days (3 times a week) or Stevens-Johnson syndrome, Lyell's syndrome, dyscrasias, severe renal impairment, pregnancy, reduction of warfarin and phenytoin. May
Bactrim lactation, G6PD deficiency, folate deficiency,
Trimethoprim 80 mg Tablet carinii pneumonia (PCP) in immunocompromised 960 mg twice daily on alternate days (3 times a week). leucopenia, neutropenia, thrombocytopenia, hypersensitivity. Use with caution in premature displace methotrexate from plasma protein
impaired renal function
patients CHILD; 6 weeks - 5 months: 120 mg twice daily on 3 agranulocytosis, megaloblastic anaemia, babies or full-term infants in the neonatal period binding sites. Increased risk of venticular
consecutive days or 7 days per week; 6 months - 5 pancytopenia or purpura, hyperkalaemia arrhythmias with amiodarone
years: 240 mg; 6 - 12 years: 480 mg
When used in scalp disorders, a small amount of cream

Concomitant topical use of sulphur and mercurial
should be rubbed gently into the roots of the hair. When
Sulphur 2% & Salicylic Acid 2% Avoid contact with eyes and other mucous Hypersensitivity, use in children less than 2 compounds can lead to the generation of
- Acne vulgaris and seborrhoeic dermatitis used in skin disorders, the cream should be applied Local irritation and dermatitis
Cream membranes years, diabetes with impaired circulation hydrogen sulphide which has a foul odour and
sparingly to the affected area. Apply once daily or until
may stain the skin black
noticeable improvement, then once or twice a week
Cardiovascular disease, manic or hypomanic
patients, renal insufficiency, neuroleptic malignant
Hypersensitivity to sulpiride,
syndrome, hyperthyroidism, pulmonary disease,
phaeochromocytoma, prolactin dependent Tramadol, increased risk of seizures. Other
urinary retention, previous hypersensitivity to other Extrapyramidal syndrome, drowsiness, dry
tumour, in combination with sultopride and central nervous system depressants, alcohol,
benzamide derivatives eg. metoclopramide, elderly mouth, urinary retention, tachycardia, postural
dopamine agonists apart from in patients with levodopa. Dopamine agonists, sultopride,
200-400 mg twice daily; 800 mg daily in predominantly patients. Pregnancy, lactation, Parkinson's disease. hypotension, dizziness, galactorrhoea,
Parkinson's disease, lactation, levodopa, class Ia halofantrine, pentamidine, sparfloxacin,
negative symptoms and 2.4 g daily in mainly positive May be exacerbated by the presence of bradycardia, gynaecomastia, amenorrhoea, sedation,
Acute and chronic schizophrenia, chronic delusional and III antiarrhythmics, certain neuroleptics moxifloxacin, bradycardiac agents,
Sulpiride 200 mg Tablet Dogmatil symptoms. Elderly, lower initial dose; increased hypokalaemia, a long QT which is either congential somnolence. Early dyskinesia, tardive
psychoses (thioridazine, chlorpromazine, levomepromazine, hypokalaemic agents, antihypertensives, if
gradually according to response. Child under 14 years or acquired (due to combination with a medicinal dyskinesia, sedation or drowsiness, transient
trifluoperazine, cyamemazine, amisulpride, treatment with neuroleptics is necessary in
not recommended product increasing the QT interval). Do not use in the hyperprolactinemia, weight gain, QT interval
tiapride, pimozide, haloperidol, droperidol), patients with Parkinson's disease receiving
event of congential galactosaemia, prolongation, orthostatic hypotension,
bepridil, cisapride, diphemanil, erythromycin, treatment with dopamine agonists, the latter must
glucose/galactose malabsorption syndrome or neuroleptic malignant syndrome
mizolastine, vincamine, halofantrine, be gradually reduced and then discontinued
lactase deficiency and children less than 6 year.
pentamidine, sparfloxacin, moxifloxacin
Parkinson's disease, renal impairment, epileptic
patients. Avoid alcohol
Cardiovascular disease, manic or hypomanic
patients, renal insufficiency, neuroleptic malignant
Hypersensitivity to sulpiride,
syndrome, hyperthyroidism, pulmonary disease,
phaeochromocytoma, prolactin dependent Tramadol, increased risk of seizures. Other
urinary retention, previous hypersensitivity to other Extrapyramidal syndrome, drowsiness, dry
tumour, in combination with sultopride and central nervous system depressants, alcohol,
benzamide derivatives eg. metoclopramide, elderly mouth, urinary retention, tachycardia, postural
dopamine agonists apart from in patients with levodopa. Dopamine agonists, sultopride,
200-400 mg twice daily; 800 mg daily in predominantly patients. Pregnancy, lactation, Parkinson's disease. hypotension, dizziness, galactorrhoea,
Parkinson's disease, lactation, levodopa, class Ia halofantrine, pentamidine, sparfloxacin,
negative symptoms; and 2.4 g daily in mainly positive May be exacerbated by the presence of bradycardia, gynaecomastia, amenorrhoea, sedation,
Acute and chronic schizophrenia, chronic delusional and III antiarrhythmics, certain neuroleptics moxifloxacin, bradycardiac agents,
Sulpiride 50 mg Capsule Dogmatil symptoms. Elderly, lower initial dose; increased hypokalaemia, a long QT which is either congential somnolence. Early dyskinesia, tardive
psychoses (thioridazine, chlorpromazine, levomepromazine, hypokalaemic agents, antihypertensives, if
gradually according to response. Child under 14 years or acquired (due to combination with a medicinal dyskinesia, sedation or drowsiness, transient
trifluoperazine, cyamemazine, amisulpride, treatment with neuroleptics is necessary in
not recommended product increasing the QT interval). Do not use in the hyperprolactinemia, weight gain, QT interval
tiapride, pimozide, haloperidol, droperidol), patients with Parkinson's disease receiving
event of congential galactosaemia, prolongation, orthostatic hypotension,
bepridil, cisapride, diphemanil, erythromycin, treatment with dopamine agonists, the latter must
glucose/galactose malabsorption syndrome or neuroleptic malignant syndrome
mizolastine, vincamine, halofantrine, be gradually reduced & then discontinued
lactase deficiency and children less than 6 year.
pentamidine, sparfloxacin, moxifloxacin
Parkinson's disease, renal impairment, epileptic
patients. Avoid alcohol
Cerebrovascular disease variant angina,
Flushing, palpitations, chest discomfort, uncontrolled hypertension, hypersensitivity to
Patient with risk of atherosclerosis, coronary artery
dizziness, fatigue, drowsiness. Sensations of sumatriptan products, severe hepatic Risk of central nervous system toxicity increased
disease, history of epilepsy. May impair ability to
tingling, heat, heaviness, pressure or tightness in impairment, previous myocardial infarction, with SSRIs, lithium and MAOIs (including
drive or operate machinery. Predisposition to
Sumatriptan 100 mg Tablet Imigran Treatment of acute migraine attacks 50 mg per attack and not more than 300 mg daily any part of the body. Nausea and vomiting. Prinzmetal's angina. Peripheral vascular disease moclobemide). Increases risk of vasospasm with
ischaemic heart disease. Hepatic or renal
Transient increase in blood pressure. Rarely: or patients who have symptoms or signs ergotamine. Ergotamine, MAOIs, 5-HT receptor
impairment. Controlled hypertension. SSRI therapy.
seizures, cardiac arrhythmia, myocardial consistent with ischaemic heart disease. History inhibitors, lithium
Lowered seizure threshold. Pregnancy and lactation
infarction, transient loss of vision, anaphylaxis of cerebrovascular accident or transient
ischaemic attack
Sumatriptan 50 mg Fast Disintegrating drive or operate machinery. Predisposition to
Imigran FDT Treatment of acute migraine attacks 50 mg per attack and not more than 300 mg daily any part of the body. Nausea and vomiting. Prinzmetal's angina. Peripheral vascular disease moclobemide). Increases risk of vasospasm with
Tablet ischaemic heart disease. Hepatic or renal
ischaemic attack
drive or operate machinery. Predisposition to
Sumatriptan 50 mg Tablet Imigran Treatment of acute migraine attacks 50 mg per attack and not more than 300 mg daily any part of the body. Nausea and vomiting. Prinzmetal's angina. Peripheral vascular disease moclobemide). Increases risk of vasospasm with
ischaemic heart disease. Hepatic or renal
ischaemic attack
Patient with risk of atherosclerosis, coronary artery dizziness, fatigue, drowsiness. Transient pain at sumatriptan products, severe hepatic
Risk of central nervous system toxicity increased
6 mg given by SC as soon as possible after onset. disease, history of epilepsy. May impair ability to inj site. Sensations of tingling, heat, heaviness, impairment, previous myocardial infarction,
with SSRIs, lithium and MAOIs (including
Treament of acute migraine attacks and cluster Dose may be repeated once after not less than 1 hour if drive or operate machinery. Predisposition to pressure or tightness in any part of the body. Prinzmetal's angina. Peripheral vascular disease
Sumatriptan 6 mg/0.5 ml Injection Imigran moclobemide). Increases risk of vasospasm with
headache needed. Max. 12 mg in 24 hours. Child not ischaemic heart disease. Hepatic or renal Nausea and vomiting. Transient increase in or patients who have symptoms or signs
ergotamine. Ergotamine, MAOIs, 5-HT receptor
recommended impairment. Controlled hypertension. SSRI therapy. blood pressure. Rarely: seizures, cardiac consistent with ischaemic heart disease. History
inhibitors, lithium
Lowered seizure threshold. Pregnancy and lactation arrhythmia, myocardial infarction, transient loss of cerebrovascular accident or transient
of vision, anaphylaxis ischaemic attack. Injection should not be given
IV
Allergic to benzocaine, procaine,
Apply to exposed areas at least 30 minutes prior to
paraphenylenediamina (found in hair dyes), thiazide
solar exposure; reapply after swimming, prolonged Antagonise antibacterial effect of sulfonamides,
Sunscreen 5 - 20% w/w Cream - Photodermatitis diuretics, sulfonamides aniline, or methylparaben Contact dermatitis and heat rash (miliaria) Hypersensitivity to a particular sunscreen agent
perspiration and after 2 hours of continuos sun reduced anticoagulant effectiveness of warfarin
may also be allergic to sunscreen containing PABA
exposure
or PABA esters
Patients who are burnt, severely hyperkalaemic
Initial test dose 5 - 10 mg may be given. Usual single Transient muscle fasciculation before relaxation, Enhanced effect by aminoglycoside,
Cardiac disease, severe trauma or electrolyte with penetrating eye wounds, malignant
dose 0.3 - 1.1 mg/kg IV. Maximum 100 mg according to increased intraocular and intragastric pressure, clindamycin, cyclophosphamide, neostigmine,
Suxamethonium Chloride 50 mg/ml lnj Scoline Muscle relaxant as an adjunct to anaesthesia imbalance, pre-existing hyperkalaemia. Ocular hyperpyrexia, massively traumatised patients or
the depth and duration of relaxation required. 2.5 - 4 post-operative pain, bradycardia, tachycardia, pyridostigmine, rivastigmine and possibly
surgery, glaucoma. Elderly those with extensive muscle degeneration eg.
mg/kg IM, maximum 150 mg hypertension, hypotension, muscarinic effects donepezil. Arrhythmias if given with digoxin
recent paraplegia
Adrenocortical insufficiency: IM, IV (over 2 minutes):
Peak plasma cortisol concentrations usually occur 45-
Due to side effects or potentially fatal allergic
60 minutes after administration CHILD less than 2 Bradycardia, hypertension, peripheral oedema,
reactions, therefore, patients should be monitored for
Synthetic ACTH (Tetracosactrin Diagnostic test to differentiate primary adrenal from years: 0.125 mg, CHILD more than 2 years and tachycardia, rash, whealing with redness at the Hypersensitivity to natural ACTH. avoid Decreased effect: Spironolactone,
Synacthen at least one hour after administration in a controlled
Acetate) 250 mcg/ml Injection secondary (pituitary) adrenocortical insufficiency ADULTS: 0.25-0.75 mg, when greater cortisol injection site, anaphylaxis, hypersensitivity injections containing benzyl alcohol in neonates hydrocortisone, cortisone
setting. Discontinue treatment by reducing the
stimulation is needed, an IV infusion may be used: reaction
dosage gradually
CHILD more than 2 years and ADULTS: 0.25 mg
administered at 0.04 mg/hour over 6 hours
Renal or hepatic insufficiency, monitor blood glucose
levels, increased risk of infections and possibly
lymphoma, hyperkalaemia, hypertension, myocardial Aminoglycosides, cisplatin, amphotericin B,
hypertrophy and neurotoxicity. Monitor blood additive or synergistic renal function impairment.
pressure, ECG, visual status, electrolytes (especially Hypertension, angina, tachycardia, pleural and Spironolactone, hyperkalaemia. NSAIDs, acute
K), haematology parameters. Children less than 2 pericardial effusion, hypotension, arrhythmias, Hypersensitivity to tacrolimus products, renal failure. Live vaccines, risk of infection in
i) Primary immunosuppressant agent for all solid organ i) 0.2 mg/kg/day in 2 divided doses ii) 0.3 mg/kg/day in year who are Epstein-Barr virus sero-negative. ventricular or septal hypertrophy, macrolides, polyoxyethylated castor oil immunocompromised hosts, reduced
Tacrolimus 0.5 mg Capsule Prograf
transplantation ii) Rescue therapy for rejection 2 divided doses Patients with allergenic disposition. May impair cardiomyopathy, gastrointestinal disturbances, (parenteral formulation) or structurally related effectiveness of vaccine. Fluconazole, nifedipine,
ability to drive or operate machinery. Continuous IV headache, tremor, dizziness, anxiety, confusion compounds, pregnancy and lactation diltiazem, clarithromycin, erythromycin,
therapy should not be continued for more than 7 and infection chloramphenicol, increased risk of tacrolimus
days. Avoid excessive exposure to sun or UV light. toxicity (nephrotoxicity, hyperglycaemia,
Increased risk for opportunistic infections such as hyperkalaemia)
activation of latent viral infections including BK virus -
associated nephropathy
Tacrolimus 1 mg Capsule Prograf
Tacrolimus 5 mg Capsule Prograf
Tacrolimus 5mg/ml Injection Prograf
Menopausal symptoms, fluid retention, Warfarin, allopurinol, ciclosporin, bromocriptine,
Caution in patients with leukopenia,
peripheral oedema, nausea, vomiting, rifampicin, clopidogrel, cyclophosphamide,
thrombocytopenia, retinopathy or with family/past Hypersensitivity to Tamoxifen. Pregnancy and
myelosuppression, tumour flare, endometrial fluorouracil, methotrexate, mitomycin, concurrent
Tamoxifen Citrate 20 mg Tablet Nolvadex Breast cancer 20-40 mg daily history of hypercoagulable states or thromboembolic lactation, pulmonary embolus history, history of
hyperplasia, polyps and small risk of endometrial use with letrozole may result in reduced letrozole
disease. Pelvic examination should be carried out for deep vein thrombosis
cancer, visual disturbance including corneal serum concentrations, aminoglutethimide may
patients on long term use of tamoxifen
changes, cataracts and retinopathy decrease tamoxifen plasma concentrations
Abnormal ejaculation, reduced libido, priapism,
Second line treatment of functional symptoms of benign Patients receiving antihypertensive treatment, intra-operative floppy iris syndrome (IFIS), History of orthostatic hypotension, severe
Tamsulosin HCl 400 mcg Extended prostatic hyperplasia (BPH) in patients who do not elderly patients, hepatic and renal impairment, dizziness, syncope, palpitations, postural hepatic insufficiency, hypersensitivity to Drugs which may reduce blood pressure,
Harnal® OCAS 400 mcg once daily
Release Tablet tolerate first line drugs or when first line drugs are during cataract surgery (risk of intra-operative floppyhypotension, rhinitis, vomiting, constipation, Tamsulosin HCl or any other component of the cimetidine, fluoxetine, ketoconazole, sildenafil
inappropriate or contraindicated iris syndrome) diarrhoea, rash, angioedema, asthenia, product
drowsiness, blurred vision
Skin ulcerations and hypersensitivity reactions
Do not apply to acutely inflammed skin. Avoid including allergic contact dermatitis, the use of Folliculitis and acne vulgaris, weeping eczema,
Massage into wet hair, rinse and repeat. Use once or
Tar, Coal Tar and Oleyl Alcohol Liquid Polytar Dandruff, seborrhoeic dermatitis and atopic dermatitis contact with eyes, do not apply coal tar preparations ultraviolet light and coal tar may produce or erythrodermic, generalized pustular psoriasis Not known
twice weekly
(other than bath emulsions) to genital or rectal areas aggravate folliculitis erythema and a smarting and photosensitivity
reaction
Technetium-99m as pertechnetate is obtained by
elution with a sterile solution of Sodium Chloride 0.9%.
The dosage depend on type of scan i) Thyroid
scintigraphy: 18.5-80 MBq (0.5-2.2 mCi) Scintigraphy
performed 20 minutes after intravenous injection ii)
Salivary gland scintigraphy: 40 MBq (1.1 mCi)
Scintigraphy performed immediately after intravenous Radiopharmaceuticals may be received, used and
injection and at regular intervals up to 15 minutes iii) administered only by authorised persons in
Meckel?s diverticulum scintigraphy: 400 MBq (10.8 designated clinical setting with appropriate
mCi) Scintigraphy performed immediately after government authorisation for the use and
intravenous injection and at regular interval up to 30 manipulation of radionuclides. Their receipt, storage,
minutes iv) Brain scintigraphy: 370-800 MBq (10-22 use, transfer and disposal are subject to the Allergic reactions include urticaria, facial
Drug interaction have been reported in brain
mCi) Rapid sequential images are taken immediately regulations and or appropriate licences of the local oedema, vasodilation, pruritus, cardiac
scintigraphy where there can be increased
within the first minute after intravenous administration, competent official organisations. After use, materials arrythmias and coma. Exposure to ionising
Sodium pertechetate is used for scintigraphy or nuclear uptake of pertechnetate in the walls of cerebral
static images 1 to 4 hours later. Thyroid and coriod associated with the preparation and administration of radiation is linked with cancer induction and a
scan particularly of the brain and thyroid to prepare ventricles as a result of methotrexate induced
Technetium-99m Sterile Generator plexus should be blocked to avoid non-specific 99mTc radiopharmaceuticals including any unused product potential for development of hereditary defects. Pregnancy and lactation
various technetium-99m labelled injections for selective vantriculitis. In abdominal imaging, drugs such as
uptake v) Cardiac and vascular scintigraphy: 740-925 and its container, should be decontaminated or For diagnostic nuclear medivine investigation,
organ imaging atropine, isoprenaline and analgesics can result
MBq (20-25 mCi) Red cells are labeled in vivo or in treated as radioactive waste and disposed of in the current evidence suggest that these adverse
in a delay in gastric emptying and redistribution
vitro by pretreating with a reducing agent. Dynamic accordance with the conditions specified by the local effects will occur with low frequency because of
of pertechnetate
images are taken in the first minute after intravenous competent authority. The administration of low radiation doses incurred
administration, followed by regular images over 30 radiopharmaceuticals creates risk for other persons
minutes vi) Gastrointestinal bleeding: 740-925 MBq (20- from external radiation or contamination from spills
25 mCi) Red cells are labeled in vivo or in vitro by of urine, vomiting etc. Radiation protection
pretreating with a reducing agent. Dynamic images are precautions in accordance with national regulations
taken in the first minutes after intravenous must therefore be taken
administration, followed by regular images at
appropriate intervals for up to 24 hours vii) Lacrimal
duct scintigraphy: 2-4 MBq each eye (50-100 mCi)
Drops are instilled into eye and dynamic images are
taken over 2 minutes, followed by static images at
appropriate intervals over 20 minutes
GI disturbances, blood dyscrasias, pigmentation,

severe hepatic disorder eg fulminant hepatitis, Patient with serious bone marrow , serious
Bone marrow depression. History of CV disease.
hepatic cirrhosis, dehydration, severe enteritis, diarrhea, serious infection], Patient receiving
Hepatic & renal disorders. Infectious complications,
Tegafur 100 mg & uracil 224 mg psychoneurologic disorders, CV disease, acute treatment with tegafur, gimeracil, oteracil Increased action of phenytoin, warfarin , other
UFT Non small cell lung cancer 300-600 mg daily in 2-3 divided doses varicella. Gastric or duodenal ulcers. Abnormal
Capsule renal failure, nephrotic syndrome, anosmia, potassium combination product or within 7 days antineoplastics or radiation therapy
glucose tolerance. Patients on chemotherapy.
interstitial pneumonia, acute pancreatitis, severe after withdrawal of this product , Pregnancy and
Children and elderly
stomatitis, GI ulceration & hemorrhage, Stevens- lactation
Johnson syndrome, Lyell's syndrome
Dizziness, headache, increased blood amylase

Renal impairment: Use caution in patients with
Treatment of chronic hepatitis B in patients with ADULT and CHILD over 16 years: 600 mg once daily. and lipase, diarrhoea, nausea, elevated ALT,
moderate-to-severe renal dysfunction and end stage Hypersensitivity to telbivudine or any component Increased risk of peripheral neuropathy when
Telbivudine 600 mg Tablet Sebivo evidence of viral replication and active liver Moderate to severe renal impairment: CrCL 30- rash, increased blood creatinine phosphokinase,
renal disease (ESRD); dosing adjustment required of the product telbivudine given with interferon alfa
inflammation 49ml/minute, 600 mg every 48 hours. CrCL fatigue, abdominal pain, dyspepsia. Increased
(ClCr
AST, myopathy, arthralgia, myalgia, malaise
Potassium-sparing diuretics, potassium
Angioedema (associated with aspirin and or
supplements, salt substitutes containing
penicillin allergy), discontinue with laryngeal stridor
Hypertension in patients who cannot tolerate ACE Headache, dizziness, upper respiratory infection Hypersensitivity to telmisartan products, potassium or other medicinal products that may
Telmisartan 40 mg Tablet Micardis 40 - 80 mg a day or angioedema of the face, tongue or glottis. Aortic
inhibitors because of cough and cough pregnancy and renal artery stenosis cause hyperkalaemia (esp digoxin, lithium) May
or mitral valve stenosis, biliary cirrhosis or biliary
increase hypotensive effect of other
obstruction, coronary artery disease and elderly
antihypertensive
Lithium, bepridil, calcitriol, calcium carbonate,
Respiratory disorders, urinary tract infection,
carbamazepine, chlorpropamide,
blood dyscrasias, precipitation of gout or latent
Hepatic impairment, progressive liver impairment, cholestyramine, corticotropin, cortisone,
diabetes, electrolyte and fluid imbalances, Cholestasis, biliary obstruction, severe hepatic
Telmisartan 80 mg & Hypertension in patients who cannot tolerate ACE severe congestive heart failure, diabetes, gout, cyclophosphamide, diazoxide, digoxin,
micardis plus 1 tablet daily metabolic and nutritional disorders, dizziness, impairment, severe renal impairment, lactation,
Hydrochlorothiazide 12.5 mg Tablet inhibitors because of cough obstructive hyperthropic cardiomyopathy, electrolyte droperidol, fludrocortisone, fluorouracil,
vertigo, visual disturbances, cardiovascular and pregnancy, refractory hypokalaemia
imbalance, high cholesterol or triglycerides memantine, methotrexate, methylprednisolone,
gastrintestinal disturbances, systemic lupus
prednisolone, propranolol, tolbutamide,
erythematosus
triamcinolone
Potassium-sparing diuretics, potassium
Angioedema (associated with aspirin and or
supplements, salt substitutes containing
penicillin allergy), discontinue with laryngeal stridor
Hypertension in patients who cannot tolerate ACE Headache, dizziness, upper respiratory infection Hypersensitivity to telmisartan products, potassium or other medicinal products that may
Telmisartan 80 mg Tablet Micardis 40 - 80 mg a day or angioedema of the face, tongue or glottis. Aortic
inhibitors because of cough and cough pregnancy and renal artery stenosis cause hyperkalaemia (esp digoxin, lithium) May
or mitral valve stenosis, biliary cirrhosis or biliary
increase hypotensive effect of other
obstruction, coronary artery disease and elderly
antihypertensive
Bacterial or viral infection, concomitant

temozolomide and steroid use (observe for
development of pneumocystis carinii pneumonia), Gastrointestinal disturbances, anorexia,
elderly patients ,hepatic or renal impairment headache, fatigue, alopecia, rash, blurred vision,
In patients with glioblastoma multiforme who fulfill all Phase I : 75mg/m2 daily for 42 days concurrent with
(severe), myelosuppression (increased risk in hearing impairment, dizziness, fever, muscle
the following criteria : i. Total /near total resection ii. radiotherapy. Phase II (Total of 6 cycle): Cycle I - Hypersensitivity to temozolomide or to any of its Valproic acid and other myelosuppressive
Temozolomide 100 mg Capsule Temodal geriatric and female patients; myelodysplastic weakness, aplastic anemia, myelodysplastic
ECOG/WHO performance status 0-2 iii. Age less than 150mg/ m2 once daily for 5/28 days Cycle 2-6 : 200mg/ components. Hypersensitivity to dacarbazine agents, trastuzumab, vaccines
syndrome and secondary malignancies may occur), syndrome, myeloid leukemia, myelosuppression,
60 years m2 once daily for 5/28 days
Pneumocystis carinii pneumonia prophylaxis neutropenia, opportunistic infection,
(required for all patients receiving concomitant pneumocystis carinii pneumonia, pancytopenia
temozolomide and radiotherapy during the 42-day
treatment of glioblastoma multiforme)
Bacterial or viral infection , concomitant
temozolomide and steroid use (observe for
development of pneumocystis carinii pneumonia) , GI disturbances, anorexia, headache, fatigue,
elderly patients ,hepatic or renal impairment alopecia, rash, blurred vision, hearing
In patients with glioblastoma multiforme who fulfill all Phase I : 75mg/m2 daily for 42 days concurrent with
(severe),myelosuppression (increased risk in impairment, dizziness, fe-ver, muscle weakness,
the following criteria : i. total /near total resection ii. radiotherapy. Phase II (Total of 6 cycle): Cycle I - Hypersensitivity to temozolomide or to any of its Valproic acid and other myelosuppressive
Temozolomide 20 mg Capsule Temodal geriatric and female patients; myelodysplastic aplastic anemia, myelodysplas-tic syndrome,
ECOG/WHO performance status 0-2 iii. Age less than 150mg/ m2 once daily for 5/28 days Cycle 2-6 : 200mg/ components , Hypersensitivity to dacarbazine agents , trastuzumab, vaccines
syndrome and secondary malignancies may occur) , Myeloid leukemia, myelosuppression,
60 years m2 once daily for 5/28 days
Pneumocystis carinii pneumonia prophylaxis neutropenia, opportunistic infection,
(required for all patients receiving concomitant pneumocystis carinii pneumonia, pancytopenia
temozolomide and radiotherapy during the 42-day
treatment of glioblastoma multiforme)
Active internal bleeding, hypersensitivity to
tenecteplase, history of cerebrovascular
Acute myocardial reinfarction where streptokinase is SBP > 180 mmHg, cerebrovascular disease, Nausea, vomiting, hemorrhage, bleeding,
Less than 60 kg: 30 mg, 60 - 69 kg: 35 mg, 70 - 79 kg: accident, intracranial or intraspinal surgery or
Tenecteplase 10,000 unit (50 mg) contraindicated due to previous streptokinase induced known/suspected stroke or TIA, recent GI or GUT epistaxis, GI & GU bleeding, superficial bleeding, Drug that affected coagulation and alter platelet
Metalyse 40 mg; 80 -90 kg: 45 mg, 90 kg or above: 50 mg. trauma within 2 months, intracranial neoplasm,
Injection antibodies. [Indicated when antibodies was given more bleeding, recent IM injection, elderly > 75 years, low reperfusion arrhythmia, hypotension, allergic function
Administer single IV bolus over 5-10 seconds arteriovenous malformation, or aneurysm, known
than 5 days and less than 12 months] body weight < 60 kg reaction, fever
bleeding diathesis, severe uncontrolled
hypertension, intracranial aneurysm
dose response (marked initial drop in blood
Carcinoma of the prostate and benign prostatic
pressure, particularly on standing) to an alpha-1
hyperplasia may cause the same symptoms.
Only for treatment of Benign Prostatic Hyperplasia. Not Initially 1 mg at night, increased in a stepwise fashion to Tachycardia, dizziness, syncope, headache and Hypersensitivity to terazosin products or other adrenergic blocking drug may be exaggerated.
Terazosin HCl 1 mg Tablet Hytrin Prostate cancer should be ruled out prior to
to be used for treatment of hypertension 2 mg, 5 mg or 10 mg once daily asthenia quinazolines Concomitant therapy with ibuprofen and
treatment. Dizziness, lightheadedness, orthostatic
antihypertensive agents has been reported to
hypotension, syncope (first-dose effect)
result in increases in blood pressure and
interference with blood pressure control


Severe liver or renal dysfunction (creatinine
Gastrointestinal symptoms, skin reactions, Induce metabolism (eg, rifampicin) and may be
Fungal infections especially onchomycosis caused by 250 mg once daily for 6 weeks for fingernails: 12 weeks clearance less than 50 ml/min or serum creatinine of
Terbinafine HCl 250 mg Tablet Lamisil headache, dizziness, vertigo, lymphocytopenia, Hypersensitivity to terbinafine inhibited by drugs which inhibit cytochrome P-
dermatophytes for toenails more than 300 µmol/L) should receive a lower dose.
and visual disturbance 450 (eg, cimetidine)
ADULT and CHILD more than 12 years : 1 inhalation 6 Hypertension, cardiovascular disease, ischaemic
Tremor, headache, nausea, tonic muscle
hourly. Severe cases : Single dose may be increased to heart disease, tachyarrhythmias, severe heart
Bronchial asthma, chronic bronchitis, emphysema and cramps, tachycardia and palpitations (reversible
Terbutaline 0.5 mg/dose Inhalation 3 inhalation. Maximum 12 inhalation/24 hour. CHILD 3- failure, unstable diabetes. Hypersensitivity to
other lung diseases where bronchospasm is a within first 1 - 2 week of treatment). Cardiac Thyrotoxicosis β-blockers may inhibit bronchodilating effect
Powder 12 year : 1 inhalation 6 hourly. Severe cases : Single sympathomimetic amines. Hypertrophic
complicating factor arrhythmias, urticaria and exanthema. Sleep and
dose may be increased to 2 inhalation. Maximum 8 cardiomyopathy, hypokalaemia. Monitor serum K
behavioural disturbances
inhalation/24 hour levels
Hypertension, cardiovascular disease, unstable Beta-blockers - inhibit bronchodilating effect.
Palpitations, tachycardia, increases in ejection
diabetes, hypersensitivity to sympathomimetic Monoamine oxidase inhibitors - increased risk of
Asthma and other conditions associated with reversible CHILD less than 7 years : 75 mcg/kg 3 times daily, 7 - fraction, increases in cardiac output have been Hypersensitivity to terbutaline and other
Terbutaline Sulphate 0.3 mg/ml Syrup Bricanyl amines, hypertrophic cardiomyopathy, tachycardia, agitation, or hypomania.
airways obstruction 15 years : 2.5 mg 2 - 3 times daily reported following subcutaneous terbutaline, sympathomimetic amines
hypokalaemia, convulsive disorders and Theophylline - decreased theophylline
tremor and tonic cramp
hyperthyroidism concentrations
SC, IM or slow IV : 250-500 mcg up to 4 times daily. Hypertension, cardiovascular disease, unstable Beta-blockers - inhibit bronchodilating effect.
Bronchial asthma, chronic bronchitis, emphysema and CHILD 2 - 15 years 10mcg/kg to a maximum of 300 diabetes, hypersensitivity to sympathomimetic Monoamine oxidase inhibitors - increased risk of
Terbutaline Sulphate 0.5 mg/ml Tremor, tonic cramp and palpitations (reversible
Bricanyl other lung diseases where broncoconstriction is a mcg. Continuous IV infusion, as a solution containing 3 - amines, hypertrophic cardiomyopathy, Thyrotoxicosis tachycardia, agitation or hypomania.
Injection within first 1 - 2 week of treatment)
complicating factor 5 mcg/ml, 1.5 - 5 mcg/minute for 8 - 10 hours; reduce hypokalaemia, convulsive disorders and Theophylline - decreased theophylline
dose for children hyperthyroidism concentrations
Beta-blockers : inhibit bronchodilating effect.
ADULT : 5 - 10 mg 2 -4 times daily, additional doses
Hypertension, cardiovascular disease, unstable Monoamine oxidase inhibitors : increased risk of
Terbutaline Sulphate 10 mg/ml Asthma and other conditions associated with reversible may be necessary in severe acute asthma. CHILD up Tremor, tonic cramp, and palpitations (reversible Hypersensitivity to terbutaline and other
Bricanyl diabetes, hypersensitivity to sympathomimetic tachycardia, agitation, or hypomania.
Inhalation Solution airways obstruction to 3 years : 2 mg, 3 - 6 years : 3 mg, 6 - 8 years : 4 mg, within first 1 - 2 week of treatment) sympathomimetic amines
amines, hypertrophic cardiomyopathy, hypokalaemia Theophylline : decreased theophylline
over 8 years : 5 mg 2 - 4 times daily
concentrations.
Hypertension, cardiovascular disease, unstable Beta-blockers - inhibit bronchodilating effect.
ADULT: Initially 2.5 mg 3 times daily for 1 - 2 week, Palpitations, tachycardia, increases in ejection
diabetes, hypersensitivity to sympathomimetic Monoamine oxidase inhibitors - increased risk of
Asthma and other conditions associated with reversible then up to 5 mg 3 times daily. CHILD less than 7 years: fraction, increases in cardiac output have been Hypersensitivity to terbutaline and other
Terbutaline Sulphate 2.5 mg Tablet Bricanyl amines, hypertrophic cardiomyopathy, tachycardia, agitation or hypomania.
airways obstruction 75 mcg/kg 3 times daily, 7 - 15 years: 2.5 mg 2 - 3 reported following subcutaneous terbutaline, sympathomimetic amines
hypokalaemia, convulsive disorders and Theophylline - decreased theophylline
times daily tremor and tonic cramp
hyperthyroidism concentrations
Fibrinolysis, bradycardia, facial pallor, increased
2 mg IV bolus over 1 minute. Maintenance: 1 - 2 mg IV Asthma, hypertension, advanced arteriosclerosis, blood pressure and ECG changes, peripheral
Terlipressin 1 mg Injection Glypressin Acute oesophageal variceal bleeding bolus 4 - 6 hourly until bleeding is controlled, up to 24 - coronary insufficiency, cardiac arrhythmias, renal vasoconstriction, increased intestinal peristalsis, Pregnancy Not known
36 hours insufficiency stool urgency and possible stool incontinence,
uterine contractions, bronchial constriction
Geriatric patient, healthy males with delayed

puberty, benign prostatic hyperthrophy, priapism and
By IM only. Hypogonadism 250 mg every 2-3 weeks. Hypersensitivity to testosterone, males with
or excessive sexual stimulation may develop,
Only for treatment of male infertility, protein deficiency To maintain an adequate androgenic effect 250 mg breast carcinoma, androderm therapy has not An increased risk of cyclosporin toxicity (renal
oligospermia may occur with prolonged
during convalescence after surgery and wasting every 3-6 weeks. Potency disorders 250 mg every 4 Oedema, signs of virilisation in women, inhibition been evaluated in women and must not be used dysfunction, cholestasis, paraesthesias),
Testosterone 250 mg/ml Injection Testoviron-Depot administration or excessive dosage. If severe upper
disorder. In women, supplementary therapy of weeks. Male climateric disorders: 250 mg every 3-4 of spermatogenesis in women. Testosterone may cause foetal harm. concurrent use with dicumarol may result in
abdominal complaints, liver enlargement or signs of
progressive mammary carcinoma weeks. Repeated 6-8 weeks courses at 2-3 months Extensive cardiac, hepatic or renal disease. bleeding
intra abdominal haemorrhage, a liver tumour should
interval History of or existing hepatic tumour
be taken into consideration. Development of
hypercalcaemia in female patients (stop treatment)
Never administer tetanus toxoid and tetanus
immunoglobulin (TIG) in same syringe (toxoid
Pain, tenderness, erythema at injection site,
will be neutralized), toxoid may be given at a
Tetanus Immunoglobulin Human 250 Prophylaxis of tetanus: IM 250 units. Treatment of fever (mild), urticaria, angioedema, muscle
Hyper-Tet Passive immunization against tetanus Known intolerence to blood or blood derivatives HIV patients separate site, concomitant administration with T-
Units/Vial Injection tetanus: IM 30 - 300 units/kg stiffness, anaphylaxis reaction, sensitization to
dependant antigen (Td) may decrease its
repeated injections
immune response, especially in individuals with
low prevaccination antibody titers
Local reaction, fever, headache and malaise,
0.5 ml at 2 months followed by second dose after 4
brachial (cervical) neuritis, Guillain-Barre Hypersensitivity to any component of the
Tetanus Toxoid Injection ATT Immunization against tetanus infection weeks and third dose after another 4 weeks. Booster Not recommended for children less than 7 years Chloramphenicol
syndrome, nausea, arthralgia, anaphylaxis, vaccine, febrile illness or acute infection
every 10 years
Arthus type urticaria
Gastrointestinal upsets, superinfection, hepatic
ADULT: 250 mg 6 hourly, increased in severe and renal toxicity, photosensitivity. Rarely, Hypersensitivity to tetracycline, patients with Absorption reduced by antacids, milk.
Tetracycline HCl 250 mg Capsule Achromycin Infections caused by susceptible pathogens infections to 500 mg every 6 - 8 hours for 1 month or Liver impairment, myasthenia gravis, lactation neutropenia, haemolytic anaemia, thrombopenia, severe renal impairment, pregnancy, children Potentiates action of anticoagulants and
more raised intracranial pressure. May exacerbate less than 8 years, premature and newborn infant sulfonylureas
existing systemic lupus erythematosus (SLE)
Gastrointestinal upsets, superinfection, hepatic

and renal toxicity, photosensitivity. Rarely, Hypersensitivity to tetracycline, patients with Absorption reduced by antacids, milk.
ADULT: 250 mg 6 hourly, increased in severe
Tetracycline HCl 250 mg Tablet Achromycin Infections caused by susceptible pathogens Liver impairment, myasthenia gravis, lactation neutropenia, haemolytic anaemia, thrombopenia, severe renal impairment, pregnancy, children Potentiates action of anticoagulants and
infections to 500 mg every 6 - 8 hours up to 3 g daily
raised intracranial pressure. May exacerbate less than 8 years, premature and newborn infant sulfonylureas
existing systemic lupus erythematosus (SLE)
Used in myocardial perfusion scintigraphy, acute
myocardial infarction and post-surgical assessment of
Thallous Chloride (Thallium-201)
- coronary artery bypass graft patency, muscle perfusion As IV infusion Not known Not known Pregnancy and lactation Not known
Injection
scintigraphy, visualisation of brain and thyroid tumours
and metastases
Active peptic ulcer disease, seizure disorders,
cardiac arrhythmias (not including
bradyarrhythmias). Patients with migraine
headaches may experience an increased frequency Tachycardia, palpitations, nausea and other Azole antifungals, ciprofloxacin, clarithromycin,
ADULT: 125 mg 3 - 4 times daily after food, increased
of headaches. Patients with congestive heart failure, gastrointestinal disturbances, headache, central erythromycin: increased risk of theophylline
Theophylline 125 mg Tablet Nuelin Reversible airways obstruction, acute severe asthma to 250 mg if required. CHILD: 1 - 15 years : 5 Hypersensitivity to theophylline
cor pulmonale, prolonged fever, hypothyroidism, nervous system stimulation, insomnia, toxicity. Caffeine: increased caffeine level.
mg/kg/dose (up to 600 mg/ day) every 3 - 4 times daily
liver disease, sepsis with multi-organ failure and arrythmias Halothane: increased risk of arrythmia
Concomittant medication use which results in
headaches may experience an increased frequency Tachycardia, palpitations, nausea and other Azole antifungals, ciprofloxacin, clarithromycin,
Theophylline 250 mg Long Acting Reversible airways obstruction and acute severe ADULT: 250 mg 2 times daily. CHILD under 12 years : of headaches. Patients with congestive heart failure, gastrointestinal disturbances, headache, central erythromycin: increased risk of theophylline
Nuelin SR Hypersensitivity to theophylline
Tablet asthma Up to 10 mg/kg body weight 2 times daily cor pulmonale, prolonged fever, hypothyroidism, nervous system stimulation, insomnia, toxicity. Caffeine: increased caffeine level.
liver disease, sepsis with multi-organ failure and arrythmias Halothane: increased risk of arrythmia
Concomitant medication use which results in
ADULT : 125 mg 3 - 4 times daily after food, increased headaches may experience an increased frequency Tachycardia, palpitations, nausea and other Azole antifungals, ciprofloxacin, clarithromycin,
Reversible airways obstruction and acute severe to 250 mg if required. CHILD 1 - 15 years : 5 of headaches. Patients with congestive heart failure, gastrointestinal disturbances, headache, central erythromycin : increased risk of theophylline
Theophylline 80 mg/15 ml Syrup Nuelin Hypersensitivity to theophylline
asthma mg/kg/dose (up to 600 mg/day) every 3 - 4 times per cor pulmonale, prolonged fever, hypothyroidism, nervous system stimulation, insomnia, toxicity. Caffeine : increased caffeine level.
day liver disease, sepsis with multi-organ failure and arrythmias Halothane : increased risk of arrythmia
Concommitant medication use which results in
Alkaline solutions, bicarbonates, carbonates,
i) For the prevention or treatment of Vitamin B1 i) Mild to chronic deficiency: 10-25 mg daily. Severe
citrates, erythromycin lactobionate, iron salts,
deficiency syndromes including beri-beri and peripheral deficiency: 200- 300 mg daily ii) 500 mg every 8 hours Use with caution with parenteral route (especially IV) Pain on injection, contact dermatitis, chronic
Thiamine HCl 100 mg/ml Injection - Hypersensitivity to thiamine or any component methohexital, neutral solutions, alkaline
neuritis associated with pellagra ii) Wernicke-Korsakoff for 2 days, followed by 100 mg 2 times daily until patient of administration pigmented purpura
barbiturate solutions (eg phenobarbital,
Syndrome can take oral dose
thiopental)
deficiency syndromes including beri-beri and peripheral deficiency: 200- 300 mg daily ii) 500 mg every 8 hours Contact dermatitis, chronic pigmented purpura,
Thiamine Mononitrate 10 mg Tablet - Not known Hypersensitivity to thiamine or any component methohexital, neutral solutions, alkaline
neuritis associated with pellagra ii) Wernicke-Korsakoff for 2 days, followed by 100 mg 2 times daily until patient skin rash, itching
thiopental)
deficiency syndromes including beri-beri and peripheral deficiency: 200 - 300 mg daily ii) 500 mg every 8 hours Contact dermatitis, chronic pigmented purpura,
Thiamine Mononitrate 3 mg Tablet - Not known Hypersensitivity to thiamine or any component methohexital, neutral solutions, alkaline
neuritis associated with pellagra ii) Wernicke-Korsakoff for 2 days, followed by 100 mg 2 times daily until patient skin rash, itching
thiopental)
Refer to specific protocols. Usually 100 mg/m2 for 5 - 7
days (acute myeloid leukaemia) or up to 2 weeks Myelosuppression, mucositis, diarrhoea,
For acute leukaemia and chronic granulocytic Hypersensitivity to thioguanine. Pregnancy,
Thioguanine 40 mg Tablet Lanvis (chronic myeloid leukaemia for accelerated/ advanced Renal or hepatic impairment hepatotoxicity, transient renal toxicity, nausea Busulphan
leukaemia lactation
disease). CHILD: 40 - 60 g/m2 daily according to and vomiting
protocol
Cardio-respiratory depression, arrhythmias,
i) ADULT : For induction 200 - 400 mg. For repeat coughing, laryngospasm, bronchoconstriction,
Reduce dose in severe liver disease, cardiovascular
injection 3 - 5 mg/kg over 10 - 15 seconds until desired haemolytic anaemia with renal failure, Porphyria, status asthmaticus, respiratory failure, Alfentanil, hydromorphone, metoclopramide,
i) General anaesthesia, induction ii) Anticonvulsant for disease, elderly, bronchiol asthma, adrenocorticol
depth of anaesthesia is obtained. Not FDA approved for vasodilation, intracranial pressure changes, shock and fixed cardiac output states, midazolam, sevoflurane, nalbuphine,
Thiopental Sodium 500 mg Injection Pentothal cases resistant to conventional anticonvulsants in the insufficiency, lactation, renal function impairment,
use in pediatric patients ii) 75 - 125 mg IV single dose; hepatotoxicity and erythema, delirium, headache, hypersensitivity to barbiturates, undergoing pentazocine, propoxyphene, alcohol,
ICU hypotension or shock, neoplastic lesion of lower
for local-anaesthetic induced convulsion: 125 - 250 mg amnesia, seizures, rash, abdominal pain, rectal rectal surgery succinylcholine, probenecid
bowel
IV over 10 minutes bleeding, thrombophlebitis, pain at injection site,
salivation, shivering
Thymol Compound Gargle - For sore throat and minor mouth inflammation To be gargled 3-4 times daily Not to be swallowed Irritant to the gastric mucosa Not known Not known
Women with hormone dependent tumours,
cardiovascular or cerebrovascular disorders
Hypersensitivity to tibolone, breast cancer
including thrombophlebitis, thromboembolic
Endometrial hyperplasia and endometrial (known or suspected), oestrogen-dependent
Complaints resulting from natural or surgical processes or a history of these conditions,
carcinoma (rare), change in body weight, vaginal neoplasms, cerebrovascular disease, history of Phenytoin, carbamazepine and rifampicin may
menopause and in cases at high risk for breast undiagnosed vaginal bleeding and severe liver
Tibolone 2.5 mg Tablet Livial 2.5 - 5mg daily bleeding, gastrointestinal upsets, changes in stroke, arterial disease, thromboembolic enchance the metabolism of tibolone and thus
carcinomas where general hormone replacement disorders. Liver disease. Patients with
liver parameters, increased facial hair growth disorders, history of cholestatic jaundice, hepatic reduce its activity
therapy is contraindicated hypercholesterolaemia and impaired glucose
and pretibial oedema tumours (benign or malignant), abnormal vaginal
tolerance. Stop tibolone 4 weeks before elective
bleeding
surgery when prolonged immobilisation after surgery
is likely
Predisposition to bleeding, including gastric or
duodenal ulcers. Underlying haematologic disorders.
Concomitant oral anticoagulant therapy or Minor gastrointestinal disorders. Rarely
i) Prevention of thrombotic stroke for patients who are
nonsteroidal antiinflammatory agents (including cutaneous allergic manifestations, Hypersensitivity to ticlopidine or its components,
sensitive /intolerant to Acetysalicylic Acid ii)
aspirin). Liver disease, patients undergoing lumbar thrombocytopenia, cholestatic icterus and or rise patients with active bleeding disorders.
Ticlopidine HCl 250 mg Tablet Ticlid Maintenance of coronary bypass surgery or 250 mg twice daily taken with food Any drugs likely to produce coagulation
puncture or surgical procedure. Ticlopidine should in transaminases. Neutropenia and Neutropenia or thrombocytopenia, severe liver
angioplasty iii) Maintenance of patency of access in
be discontinued if the absolute neutrophil count falls thrombocytopenia (monitor full blood count impairment
patients on chronic haemodialysis
below 1200/mm3 or if the platelet count falls below weekly initially)
80,000/mm3. If possible, ticlopidine should be
discontinued 10 to 14 days prior to surgery
Cathecolamine-depleting drugs. Concurrent

History of atopy or a history of severe anaphylactic Bradycardia, hypotension, confusion, Bronchial asthma or a history of bronchial administration of oral or systemic beta-
Timoptol,timoptol- Elevated intraocular pressure, chronic open angle Initially, 1 drop of 0.25% 2 times daily, if clinical reaction to a variety of allergens, pregnancy and depression, dizziness, fatigue, abdominal pain, asthma, severe COPD, sinus bradycardia, adrenergic blockers. Concurrent use of beta-
Timolol Maleate 0.5% Eye Drops
XE,Timo-comod galucoma response is not adequate, 1 drop of 0.5% 2 times daily lactation. May impair ability to drive or operate diarrhoea, nausea, vomiting, dyspepsia, dry eye, second or third degree atrioventricular block, blockers and digitalis with diltiazem or verapamil
machinery ocular burning, corneal anaesthesia overt cardiac failure and cardiogenic shock may have additive effects in prolonging
atrioventricular conduction time. Quinidine
i) ADULT : 2 g as a single dose for 2 - 3 days. CHILD 3
Neurological disturbances, gastrointestinal
years and older : 50 mg/kg daily for 3 days ii) ADULT :
disturbances, anorexia and metallic taste, History of blood dyscrasias, patients with active Cholestyramine, cimetidine, cyclosporine,
i) Amoebiasis ii) Urogenital trichomoniasis and 2 g as a single dose (repeated once if necessary). If abnormal neurological signs develop, discontinue
Tinidazole 500 mg Tablet Fasigyn hypersensitivity, leucopenia, headache, organic neurological disorders, first trimester of disulfiram, fluorouracil, ketoconazole, lithium,
giardiasis Sexual partners should be treated concomitantly with therapy
tiredness, furry tongue, dark urine, palpitation, pregnancy and lactation phenobarbital, phenytoin, tacrolimus, warfarin,
the same dose. CHILD 6 years and older : single dose
drug-induced rash
of 1 gram
Not for ophthalmic use, avoid contact with eyes,
avoid douching, may damage rubber or latex
Skin fungal infections resistant to antifungal drugs such Gently massage into the affected and surrounding area Local irritation, burning, rash, erythema, itching Hypersensitivity to tioconazole and midazole
Tioconazole 1% Cream Trosyd contraceptives and additional contraceptive Not known
as miconazole and clotrimazole 1-2 times daily and headache antifungal agents
measures are necessary during local administration,
lactation, pregnancy
Hypersensitivity to tioconazole or miconazole
Tioconazole 100 mg Vaginal Tablet Gyno-Trosyd Vulvovaginal candidiasis Insert nightly on retiring for 3-6 or 14 days Diabetes, pregnancy, HIV or AIDS Burning, rash, erythema, itching Not known
products
Apply 4.6 g intravaginally prior to bedtime as a single Hypersensitivity to tioconazole or miconazole
Tioconazole 6.5% Vaginal Ointment Gyno-Trosyd Vulvaginal candidiasis Diabetes, pregnancy, HIV or AIDS Burning, rash, erythema, itching Not known
dose therapy, therapy may extend to 7 days products
Long term maintenance treatment of bronchospasm Xerostomia, upper respiratory tract infection, Hypersensitivity to tiotropium and its derivatives
Inhale the contents of one capsule once daily with the Myasthenia gravis, narrow angle glaucoma, prostatic
Tiotropium Bromide Inhalation 18 mcg and dypsnoea associated with COPD. Tiotropium has sinusitis, rash, cataract, angioedema, or any component of the formulation (contains
Spiriva handihaler device at the same time of day. Child and hyperplasia, renal impairment, pregnancy, bladder Beta-agonists and other anticholinergics
Capsules usually been added to standard therapy (e.g. inhaled tachycardia, urinary retention, angina pectoris, lactose). Not for use as an acute ("Rescue")
adolescent under 18 years, not recommended neck obstruction, moderate to severe renal failure
steroids, theophylline, albuterol rescue) hypercholesterolemia, hyperglycemia bronchodilator
Renal impairment, hepatic impairment, major Abnormal bleeding within 30 days, stroke within
Unstable angina or non-ST segment elevation surgery or severe trauma within 3 months, traumatic 30 days or any history of haemorrhagic stroke,
myocardial infarction with the following: elevated or protracted cardiopulmonary resuscitation, organ intracranial disease (aneurysm, neoplasm or
By IV infusion, 0.4 mcg/kg/min for 30 minutes, then 0.1 Bleeding manifestations, reversible
Tirofiban HCl 0.25 mg/ml Injection Aggrastat cardiac markers, refractory chest pain, ST-segment biopsy, recent bleeding including history of arteriovenous malformation), severe Drugs that affect haemostasis (eg warfarin)
mcg/kg/min for at least 48 hours, maximum 108 hours thrombocytopenia, nausea, fever, headache
changes and thrombolysis in myocardial infarction gastrointestinal bleeding or genitourinary bleeding, hypertension, haemorrhagic diathesis, increased
(TIMI) risk score 4 platelet disorder or history of thrombocytopenia; prothrombin time or INR, thrombocytopenia and
platelet count < 150,000 cells/mm3 breast-feeding
Significant bladder outlet obstruction, gastrointestinal

Urinary retention, uncontrolled narrow angle
Treatment of overactive bladder with symptoms of 4 mg once daily. May decrease to 2 mg once daily obstruction disorders, renal disease, hepatic Mild to moderate antimuscarinic effects, dryness Erythromycin, clarithromycin, metoclopramide,
Tolterodine Tartrate ER 2 mg Capsule Detrusitol SR glaucoma, toxic megacolon, myasthenia gravis.
urinary, frequency or urge incontinence depending on response and tolerability disease, autonomic neuropathy, hiatus hernia, of mouth, dyspepsia, reduced lacrimation cisapride
concomitant treatment with CYP3A4 inhibitors
Significant bladder outlet obstruction, gastrointestinal

Urinary retention, uncontrolled narrow angle
Treatment of overactive bladder with symptoms of 4 mg once daily. May decrease to 2 mg once daily obstruction disorders, renal disease, hepatic Mild to moderate antimuscarinic effects, dryness Erythromycin, clarithromycin, metoclopramide,
Tolterodine Tartrate ER 4 mg Capsule Detrusitol SR glaucoma, toxic megacolon, myasthenia gravis.
urinary, frequency or urge incontinence depending on response and tolerability disease, autonomic neuropathy, hiatus hernia, of mouth, dyspepsia, reduced lacrimation cisapride
concomitant treatment with CYP3A4 inhibitors
Avoid abrupt withdrawal, hepatic or renal Cognitive dysfunction, sedation, diarrhoea,
ADULT: 200 - 400 mg/day in 2 divided doses. impairment, behavioral disorders or cognitive deficit, weight loss, dizziness, abdominal pain, nausea,
Plasma concentration decreased by phenytoin
Maximum 1600 mg/day. CHILD: initial 25 mg (1-3 paraesthesia, predisposition to or history of anorexia, confusion, impaired speech, ataxia,
and carbamazepine. Metabolism of oral
Topiramate 100 mg Tablet Topamax Add-on therapy for intractable partial epilepsy mg/kg/day), then titrated by 1-3 mg/kg/1-2 weeks in 2 nephrolithiasis, pregnancy, lactation. Ensure drowsiness, fatigue, asthenia, visual Hypersensitivity to topiramate, breast feeding
contraceptive (oestrogens and progestogens)
divided doses. Maintenance 5-9 mg/kg/day in 2 divided adequate hydration. May impair ability to drive or disturbances, nystagmus, taste disorder,
accelerated (reduced contraceptive effect)
doses operate machinery. Potential for an increase in risk leucopenia, renal calculi, somnolence and
of suicidal thoughts or behaviours paraesthesia
Topiramate 15 mg Capsule Sprinkle Topamax Add-on therapy for intractable partial epilepsy mg/kg/day), then titrated by 1-3 mg/kg/1-2 weeks in 2 nephrolithiasis, pregnancy, lactation. Ensure drowsiness, fatigue, asthenia, visual Hypersensitivity to topiramate, breast feeding
Topiramate 25 mg Capsule Sprinkle Topamax Add-on therapy for intractable partial epilepsy mg/kg/day), then titrated by 1-3 mg/kg/1-2 weeks in 2 nephrolithiasis, pregnancy, lactation. Ensure drowsiness, fatigue, asthenia, visual Hypersensitivity to topiramate, breast feeding
Maximum 1600 mg/day. CHILD: Initial 25 mg (1-3 paraesthesia, predisposition to or history of anorexia, confusion, impaired speech, ataxia,
Impaired biliary or renal function, liver dysfunction
(especially cholestasis. Manganese blood levels and
Trace Elements and Electrolytes Only to be used to cover daily loss of electrolyte and 10 ml added to 500-1000 ml solution, given by IV Total biliary obstruction. Should not be given
Addamel Solution liver function should be monitored regularly Not known Not known
(Adult) Solution trace elements for patient on parenteral nutrition infusion undiluted
(monthly). Should be stopped if manganese levels
rise into the potentially toxic range
According to the needs of the patient. INFANT and
CHILD weighing 15 kg or less: Basal requirements of
the included trace elements are covered by 1 ml/kg/day
Trace Elements and Electrolytes Only to be used to cover daily loss of electrolyte and to a maximum dose of 15 ml. CHILD weighing 15 kg or Impaired or immature biliary. Impaired renal function. Fructose intolerance. Should not be given
Ped-el Not known Not known
(Paediatric) Solution trace elements for patient on parenteral nutrition more, a daily dose of 15 ml, should meet basic trace Monitor serum aluminium in neonate undiluted
element requirements. However, for patients weighing
more than 40 kg the adult preparation trace element
should be used
Amitryptiline, chlorpromazine, clozapine,
dothiepin, fluoxetine, fluvoxamine, haloperidol,
risperidone, sertraline, sulpiride, thioridazine,
Sweating, dizziness, vomiting, dry mouth,
Reduced level of consciousness, respiratory trifluoperazine: increased risk of seizures.
gastrointestinal disturbances, cerebral
disorders, increased intracranial pressure, Moclobemide, selegiline: nausea, vomiting,
convulsions especially on co-medication with Narcotic withdrawal treatment, hypersensitivity,
Post-operative pain, chronic cancer pain, pregnancy, lactation, history of epilepsy. Opiate cardiovascular collapse, respiratory depression,
neuroleptics, physical dependence. Rarely, acute alcoholism. Acute intoxication with alcohol,
Tramadol HCl 100 mg Suppository Tramal analgesia/pain relief for patients with impaired renal 100 mg rectally dependence, hypersensitivity to morphine-like seizures. Carbamazepine: decreased tramadol
palpitations, tachycardia, faintness, circulatory analgesics, sedatives or psychotropic drugs.
function analgesics, children less than 1 year. Myxedema, efficacy. Digoxin: increased risk of digoxin
collapse, headaches, constipation, skin MAOI therapy
hypothyroidism or hypoadrenalism. Hepatic or renal toxicity (nausea, vomiting, cardiac arrhythmias).
reactions. Very rarely, muscular weakness,
function disorders Increased incidence of seizures when used with
altered appetite, micturition disturbances
tricyclic antidepressants eg cyclobenzaprine,
MAOI, SSRIs, neuroleptic agents and other
drugs that lower the seizure threshold
50 - 100 mg every 4 hours. Max : 400 mg daily. Not neuroleptics, physical dependence. Rarely, acute alcoholism. Acute intoxication with alcohol,
Tramadol HCl 100 mg/ml Drops Tramal analgesia/pain relief for patients with impaired renal dependence, hypersensitivity to morphine-like seizures. Carbamazepine: decreased tramadol
recommended in children palpitations, tachycardia, faintness, circulatory analgesics, sedatives or psychotropic drugs.
function. analgesics, children less than 1 year. Myxedema, efficacy. Digoxin: increased risk of digoxin
50 - 100 mg every 4 hours. Max 400 mg daily. Not neuroleptics, physical dependence. Rarely, acute alcoholism. Acute intoxication with alcohol,
Tramadol HCl 50 mg Capsule Tramal analgesia/pain relief for patients with impaired renal dependence, hypersensitivity to morphine-like seizures. Carbamazepine: decreased tramadol
recommended in children palpitations, tachycardia, faintness, circulatory analgesics, sedatives or psychotropic drugs.
function analgesics, children less than 1 year. Myxedema, efficacy. Digoxin: increased risk of digoxin
Post-operative pain, chronic cancer pair and ADULT: By IM / IV inj. (over 2-3 mins) or by IV infusion. pregnancy, lactation, history of epilepsy. Opiate cardiovascular collapse, respiratory depression,
neuroleptics, physical dependence. Rarely, acute alcoholism. Acute intoxication with alcohol,
Tramadol HCl 50 mg/ml Injection Tramal analgesia/pain relief for patients with impaired renal Initially 100 mg then 50 - 100 mg every 4 - 6 hours. dependence, hypersensitivity to morphine-like seizures. Carbamazepine: decreased tramadol
palpitations, tachycardia, faintness, circulatory analgesics, sedatives or psychotropic drugs.
function Max: 600 mg daily. Child not recommended analgesics, children less than 1 year. Myxedema, efficacy. Digoxin: increased risk of digoxin
Cardiovascular disease, cerebrovascular disease,
Severe renal impairment, thromboembolic
ADULT: Slow IV 0.5-1 g (10 - 15 mg/kg) 3 times daily. concomitant antifibrinolytic therapy. Concomitant
Transamin, Nausea, vomiting, diarrhoea, hypotension, disease, intravascular clotting process, Anti-inhibitor coagulant complex oral
Tranexamic Acid 100 mg/ml Injection Haemorrhage associated with excessive fibrinolysis Continuous infusion at a rate of 25 - 50 mg/kg daily. therapy with oestrogens or thrombolytics. Renal
Cyklokapron thrombosis, disturbances in colour vision disturbance of colour vision, subarachnoid contraceptive, oestrogen, tretinoin
CHILD: slow IV 10 mg/kg/day 2-3 times daily impairment and transurethral prostatectomy
haemorrhage
(potential for intravesicular clotting)
Cardiovascular disease, cerebrovascular disease,
ADULT: 1-1.5 g (15-25 mg/kg) 2-4 times daily. CHILD: Severe renal impairment, thromboembolic
concomitant antifibrinolytic therapy. Concomitant
25 mg/kg/day 2-3 times daily. Menorrhagia (initiated Nausea, vomiting, diarrhoea, hypotension, disease, intravascular clotting process, Anti-inhibitor coagulant complex, oral
Tranexamic Acid 250 mg Capsule Transamin Haemorrhage associated with excessive fibrinolysis therapy with oestrogens or thrombolytics. Renal
when menstruation has started), 1 g 3 times daily for up thrombosis, disturbances in colour vision disturbance of colour vision and subarachnoid contraceptive, oestrogen, tretinoin
impairment and transurethral prostatectomy
to 4 days; maximum 4 g daily haemorrhage
(potential for intravesicular clotting)
Cardiac dysfunction, cardiotoxic therapy, infusion
Used only in adjuvant setting for patients with HER2 Initial loading dose is 4 mg/kg administered as a 90 reaction, pulmonary toxicity, anaphylaxis, Diarrhoea, anaemia, leukopenia,
Hypersensitivity to trastuzumab or foreign Cyclophosphamide, daunorubicin, daunorubicin
over-expressed breast cancer, that is HER2 3+ by minutes IV infusion. Subsequent doses is 2 mg/kg angioedema, acute respiratory distress syndrome cardiomyopathy, hypersensitivity reaction,
Trastuzumab 440 mg Injection proteins (Chinese Hamster Ovary cell proteins or citrate liposome, doxorubicin, epirubicin,
immunohistochemistry and over-expressed by FISH administered as 30 minutes IV infusion weekly for 51 (ARDS), benzyl alcohol hypersensitivity, geriatric, nephrotic syndrome, interstitial pneumonia,
murine protein) or any other product component idarubicin, warfarin
(Fluorescence in situ hybridization) and high risk group weeks intrinsic lung disease, extensive tumor involvement complication of infusion
with dyspnoea at rest, neutropenia
Exposure to sunlight including sunlamp should be
minimized. Avoid contact with eyes, mouth, angle of
Apply thinly to the affected area once daily or twice
Acne vulgaris, recalcitrant cases of acne (comedonal the nose and mucous membrane. Eczema, sunburn, Erythema, oedema, blistering, hypopigmentation Acute dermatitis, rosacea, hypersensitivity to
Tretinoin 0.01% Gel Retin-A daily. Avoid exposure to sunlight. Duration of treatment: Not known
type) pregnancy and lactation. Special caution is indicated or hyperpigmentation, sensitivity to sunlight tretinoin or parabens
8-12 weeks is required before any noticeable response
in cases of simultaneous treatment with other
preparations
Betamethasone, betamethasone dipropionate,
Apply thinly to the affected area once daily or twice minimized. Avoid contact with eyes, mouth, angle of
clotrimazole, dexamethasone, fluconazole,
Acne vulgaris and recalcitrant cases of acne daily. Avoid exposure to sunlight. Duration of treatment: the nose and mucous membrane. Eczema, sunburn, Erythema, oedema, blistering, hypopigmentation Acute dermatitis, rosacea. Hypersensitivity to
Tretinoin 0.05% Cream Retin-A hydrocortisone, ketoconazole, methotrexate,
(comedonal type) 8 - 12 weeks is required before any noticeable pregnancy and lactation. Special caution is indicated or hyperpigmentation, sensitivity to sunlight tretinoin or parabens
methylprednisolone, paclitaxel, prednisolone,
response in cases of simultaneous treatment with other
tetracycline, tranexamic acid, triamcinolone
preparations
Betamethasone, betamethasone dipropionate,
Apply thinly to the affected area once daily or twice minimized. Avoid contact with eyes, mouth, angle of
clotrimazole, dexamethasone, fluconazole,
Acne vulgaris and recalcitrant cases of acne daily. Avoid exposure to sunlight. Duration of treatment: the nose and mucous membrane. Eczema, sunburn, Erythema, oedema, blistering, hypopigmentation Acute dermatitis, rosacea. Hypersensitivity to
Tretinoin 0.1% Cream Retin-A hydrocortisone, ketoconazole, methotrexate,
(comedonal type) 8 - 12 weeks is required before any noticeable pregnancy and lactation. Special caution is indicated or hyperpigmentation, sensitivity to sunlight tretinoin or parabens
methylprednisolone, paclitaxel, prednisolone,
response in cases of simultaneous treatment with other
tetracycline, tranexamic acid, triamcinolone
preparations
Hypersensitivity to any of its components, fungal
Triamcinolone Acetonide 0.1% Oral Tuberculosis, peptic ulcer, diabetes mellitus, or bacterial infections of the mouth or throat,
Kenalog in Orabase Oral and perioral lesions Apply a thin layer to affected area 2-4 times daily Prolonged use may lead to possible absorption Minor interaction with hypoglycaemic agents
Paste pregnancy herpetic lesions of known viral origin or intraoral
lesions
Local atrophy, post injection flare, pigmentation
Intercurrent infection, hypothyroidism, cirrhosis,
Smaller joints: 2.5 - 5 mg and larger joints: 5 - 15 mg. changes, sodium and fluid retention, peptic ulcer, Phenytoin, phenobarbitone, rifampicin,
Triamcinolone Acetonide 10 mg/ml active or latent tuberculosis, renal insufficiency, Systemic fungal infection, unstable or infected
Kenacort Inflammation of joints, bursae and tendon sheaths Treatment should be limited to 1 mg/injection site to impaired wound healing, purpura, striae, carbamazepine, hypoglycaemics, diuretics,
Injection cardiac failure, diabetes, glaucoma, myasthenia joints, lactation
prevent cutaneous atrophy increased ocular/intracranial pressure with anticholinesterases, salicylates
gravis, pregnancy
cushingnoid state, growth retardation
Local atrophy, post injection flare, pigmentation
Intercurrent infection, hypothyroidism, cirrhosis,
changes, sodium and fluid retention, peptic ulcer, Phenytoin, phenobarbitone, rifampicin,
Triamcinolone Acetonide 40 mg/ml Allergies, dermatoses, rheumatoid arthritis and active or latent tuberculosis, renal insufficiency, Systemic fungal infection, unstable or infected
Kenacort-A 40-80 mg deep into the gluteal muscle impaired wound healing, purpura, striae, carbamazepine, hypoglycemics, diuretics,
Injection opthalmic diseases cardiac failure, diabetes, glaucoma, myasthenia joints, lactation
increased ocular/intracranial pressure with anticholinesterases, salicylates
gravis, pregnancy
cushingnoid state, growth retardation
Use 3-4 times daily when the skin problem is active and
Triclosan 2% w/w Emulsion Phisohex Acne, pimples and minor skin infections Avoid contact with eyes Hypersensitivity to any component Hypersensitivity to any component Not known
daily after the problem has cleared up
Tramadol, increased risk of seizures. Lithium,
weakness, dyskinesias, increased
extrapyramidal symptoms, encephalopathy and
Seizures, extrapyramidal effects, blood brain damage. Procyclidine, decreased
Tardive dyskinesias may develop, concomitant dyscrasias, agranulocytosis, neuroleptic phenothiazine serum concentrations and
lithium therapy (encephalopathic syndrome), may malignant syndrome, dry mouth, constipation, effectiveness, enhanced anticholinergic effects
ADULT: Initially 5 mg twice daily, increase by 5 mg after
increase anginal pain, neuroleptic malignant orthostatic hypotension, blurred vision, tardive Coma, bone marrow depression, hypersensitivity (ileus, hyperpyrexia, sedation, dry mouth).
1 week, then at 3-day intervals. Maximum 40 mg/day.
syndrome, glaucoma or retinopathy. If affected by dyskinesia, urinary retention, photosensitivity, to trifluoperazine products and other Phenytoin, increased or decresed phenytoin
Trifluoperazine HCI 5 mg Tablet Stelazine Psychotic disorder CHILD up to 12 years: Initially up to 5 mg daily in
drowsiness do not drive or operate machinery. rash, nausea, tachycardia, dizziness, fatigue, phenothiazines, pre-existing liver damage, levels and possibly reduced phenothiazine
divided doses adjusted to response, age and body
cardiovascular or respiratory disease, headache, weight gain, jaundice, dystonic central nervous system depression levels. Ethanol, increased central nervous
weight
phaeochromocytoma, parkinsonism, epilepsy, renal reaction in children, sensitivity reactions eg system depression and an increased risk of
or hepatic impairment, pregnancy and lactation agranulocytosis, leucopenia, leucocytosis and extrapyramidal reactions. Amphotericins, class Ia
haemolytic anaemia and III antiarrhythmics, beta2 agonists,
acetazolamide, central alpha2 agonists, systemic
corticosteroids, diuretics, MAOIs, tricyclic
antidepressants
Pregnancy especially first trimester, unstable angina, Gastrointestinal disorders such as nausea and
Trimetazidine 20 mg Tablet Vastarel Prophylactic treatment of episodes of angina pectoris 20 mg 3 times daily Concomitant administration with MAOIs Not known
hypertension, renal or hepatic insufficiency vomiting
35 mg twice daily in the morning and evening with Pregnancy especially first trimester, unstable angina, Gastrointestinal disorders such as nausea and
Trimetazidine 35 mg MR Tablet Vastarel MR Prophylactic treatment of episodes of angina pectoris Concomitant administration with MAOIs Not known
meals hypertension, renal or hepatic insufficiency vomiting
ADULT: 200 mg daily in 1 or 2 divided doses or 300 mg
Rash, pruritus, exfoliative dermatitis, nausea,
daily as a single dose. Acute infection: 200 mg twice Renal/hepatic impairment, folate deficiency, elderly Hypersensitivity to trimethoprim or any Increased effect, toxicity or levels of phenytoin,
Treatment of urinary tract infections due to susceptible vomiting, anorexia, and infrequent hematologic
Trimethoprim 100 mg Tablet Alprim daily. CHILD: 6 - 12 years: 100 mg twice daily; 6 and malnourished patients or with possible folate component, megaloblastic anaemia due to folate increased myelosuppression with methotrexate,
pathogens reactions (thrombocytopenia, leucopenia and
months - 5 years: 50 mg twice daily. 6 weeks - 5 deficiency deficiency may increase levels of digoxin
megaloblastic anaemia) with chronic high dose
months: 25mg twice daily
ADULT: 200 mg daily in 1 or 2 divided doses or 300 mg
Rash, pruritus, exfoliative dermatitis, nausea,
daily as a single dose. Acute infection: 200 mg twice Renal/hepatic impairment, folate deficiency, elderly Hypersensitivity to trimethoprim or any Increased effect, toxicity or levels of phenytoin,
Treatment of urinary tract infections due to susceptible vomiting, anorexia, and infrequent hematologic
Trimethoprim 300 mg Tablet Alprim daily. CHILD: 6 - 12 years: 100 mg twice daily; 6 and malnourished patients or with possible folate component, megaloblastic anaemia due to folate increased myelosuppression with methotrexate,
pathogens reactions (thrombocytopenia, leucopenia and
months - 5 years: 50 mg twice daily. 6 weeks - 5 deficiency deficiency may increase levels of digoxin
megaloblastic anaemia) with chronic high dose
months: 25mg twice daily
5 - 10 mg daily, 2 - 4 hours before exposure to sunlight. Porphyria, concomitant photosensitizing drugs,
Overdose and or overexposure may result in serious Gastrointestinal discomfort, severe sunburn Concurrent use of trioxsalen and furocoumarin
Trioxsalen 5 mg Tablet Trisoralen Vitiligo To increase pigmentation: 10 mg daily, 2 hours prior to children 12 years and under, leukoderma of
burning and blistering (high dose), phototoxicity foods may result in severe burns
UV irradiation infection, acute lupus erythematosus
Diabetes, hypertension, heart disease, Drowsiness, sleep disturbances, skin rashes,
ADULT and CHILD more than 12 year : 10 ml. CHILD 6
hyperthyroidism, elevated intraocular pressure, dryness of nose, mouth and throat, hypotension Antihypertensives, tricyclic antidepressants,
Triprolidine HCl 1.25 mg and Decongestion of the upper respiratory tract in common - 12 years : 5 ml, 2 - 5 years : 2.5 ml, 6 months to less
prostatic enlargement, asthma, chronic obstructive or hypertension, tachycardia, anorexia, nausea, Angle-closure glaucoma, hypersensitivity to decongestants, appetite suppressants,
Pseudoephedrine HCl 30 mg per 5 ml Actifed cold, hay fever, allergic and vasomotor rhinitis and than 2 years : 1.25 ml. Doses to be taken twice daily or
pulmonary disease, prostatic hypertrophy, pyloric vomiting, constipation, diarrhea, abdominal pain, triprolidine products, neonates amphetamine-like psychostimulant, other
Syrup sinusitis three times daily. Not FDA approved in children less
obstruction, stenosing peptic ulcer and avoid wheezing, tightness of chest, impotence, blurred sympathomimetics
than 6 years old
operating vehicles and machinery vision, urinary retention
ADULT 2.5 mg every 4 - 6 hours; maximum dose 10

mg/day. CHILD 6 - 12 years : 1.25 mg every 4 - 6 Diabetes, hypertension, heart disease, Drowsiness, sleep disturbances, skin rashes,
hours; maximum dose 5 mg/day, 2 - 4 years : 0.625 mg hyperthyroidism, elevated intraocular pressure, dryness of nose, mouth and throat, hypotension Antihypertensives, tricyclic antidepressants,
Decongestion of the upper respiratory tract in common
Triprolidine HCl 2.5 mg and every 4 - 6 hours; maximum dose 2.5 mg/day, 4 - 6 prostatic enlargement, asthma, chronic obstructive or hypertension, tachycardia, anorexia, nausea, Angle-closure glaucoma, hypersensitivity to decongestants, appetite suppresants,
Actifed cold, hay fever, allergic and vasomotor rhinitis and
Pseudoephedrine HCl 60 mg Tablet years : 0.938 mg every 4 - 6 hours; maximum dose pulmonary disease, prostatic hypertrophy, pyloric vomiting, constipation, diarrhoea, abdominal triprolidine products, neonates amphetamine-like psychostimulant, other
aerotitis
3.744 mg/day, 4 months - 2 years : 0.313 mg every 4-6 obstruction, stenosing peptic ulcer. May impair ability pain, wheezing, tightness of chest, impotence, sympatomimetics
hours; maximum dose 1.25 mg/day. Not FDA approved to drive or operate machinery blurred vision, urinary retention
in children less than 6 years old
Diabetes, hypertension, heart disease, Drowsiness, sleep disturbances, skin rashes,

ADULT and CHILD more than 12 years : 10 ml. CHILD hyperthyroidism, elevated intraocular pressure, dryness of nose, mouth and throat, hypotension Antihypertensives, tricyclic antidepressants,
Unproductive cough accompanied by congestion of the
Triprolidine HCl, Pseudoephedrine 6 - 12 years : 5 ml, 2 - 5 years : 2.5 ml, 2 months - 2 prostatic enlargement, asthma, chronic obstructive or hypertension, tachycardia, anorexia, nausea, Angle-closure glaucoma, hypersensitivity to decongestants, appetite suppresants,
Actifed Comp upper respiratory tract including congestion with an
HCl and Dextromethorphan Linctus years : 1.25 ml. Doses to be taken 3 times daily. Not pulmonary disease, prostatic hypertrophy, pyloric vomiting, constipation, diarrhoea, abdominal triprolidine products, neonates amphetamine-like psychostimulant, other
allergic component
FDA approved in children less than 6 years old obstruction, stenosing peptic ulcer. May impair ability pain, wheezing, tightness of chest, impotence, sympatomimetics
to drive or operate machinery blurred vision, urinary retention
Palpitations, headache, sleep disturbances,
Prostatic carcinoma patients with impending spinal tiredness, emotional lability, tremors and
Treatment of confirmed central precocious puberty cord compression or severe urinary tract disorders, dizziness. In men, hot flushes, impotence, loss of Hypersensitivity reaction, pregnancy, hormone-
3.75 mg IM injection every 4 weeks. Period of treatment
Triptorelin 3.75 mg Injection Decapeptyl (preterm sexual development) in girls under 9 years, exacerbation of premenstrual syndrome, renal libido, rarely gynaecomastia. Depot injection independent prostate carcinoma, clinically Not Known
should not exceed 6 months
boys under 10 years of age insufficiency. Bone loss during long-term therapy in causes increased enzyme activity and manisfest osteoporosis or risk of osteoporosis
women with endometriosis or uterine leiomyoma thrombophlebitis. Breakthrough bleeding in
women
Individuals susceptible to belladona alkaloids, Increased intraocular pressure, dryness of Antimuscarinic effects potentiated by
Topical use to produce cycloplegic refraction for inflammed eyes, pregnancy, children, elderly. Infants mouth, transient stinging, allergic reactions, Primary glaucoma or a tendency toward concomitant use of amantadine, tricyclic
Tropicamide 1% Eye Drops Mydriacyl 1 - 2 drops several times a day
diagnostic purposes and children, may cause central nervous system tachycardia, headache, parasympathetics glaucoma. Sensitivity to tropicamide antidepressants, phenothiazine and
disturbances stimulation, blurred vision, photosensitivity butyrophenones and antihistamines
Thrombocytopenia, leucocytosis, atrial fibrillation,
As an adjunct in the management of acute inflammation
Trypsin & Chymotrypsin 5000 ventricular tachycardia, hypotension, Patient with thromboembolic disease requiring
Chymar of traumatic or surgical origin, reduction of viscosity of 5000 units IM 1-3 times daily Renal insufficiency Heparin, succinylcholine
units/vial Injection thromboembolism, fever, nausea, vomiting, anticoagulant therapy
mucous/ sputum in upper respiratory disease
nephrotoxicity, anaphylaxis
Sensitivity to tuberculin may be diminished in the
following conditions: viral or severe bacterial
infection including HIV infection and severe
tuberculosis, neoplastic disease particularly Pain and pruritus may occur at the injection site,
lymphoma, sarcoidosis, corticosteroid or occasionally with vesiculation, ulceration or
Subcutaneous injection, hypersensitivity to
immunosuppressive therapy, recent administration necrosis in highly sensitive persons. If given to
tuberculin purified protein derivative, previous Corticosteroid, immunosuppressive therapy, live
Tuberculine PPD Injection Tuberculine For routine Mantoux (tuberculin sensitivity) test 10 units is injected intradermally of live virus vaccines, ultraviolet light treatment, patients with tuberculosis a severe reaction may
severe reaction (e.g. Vesiculation, ulceration, virus vaccines
chronic renal failure and malnutrition. Tuberculins occur. Granuloma has been reported.
necrosis)
may be adsorbed onto the surface of syringes and Hypersensitivity reactions, including anaphylaxis,
should therefore be administered immediately. to tuberculins have been reported rarely
Tuberculin skin tests should not generally be
administered to known tuberculin reactors because
of the risk of a severe reaction at the test site
Nausea, vomiting, abdominal pain, rarely Congenital or acquired immunodeficient state, Immunosuppressive, immune globulins & blood
Active immunization against typhoid fever in adult and ADULT and CHILD 6 years of age or older, 1 capsule
Typhoid Vaccine Capsule Vivotif Berna Pregnancy diarrhea, headache, fever, hypersensitivity acute febrile illness, acute gastro-intestinal products, sulfonamides & certain antibiotics,
child 6 years of age or older on days 1, 3 and 5
reaction including rarely anaphylaxis illness mefloquine
Redness, pain and swelling at injection site. Acute febrile or gastrointestinal illness,
0.5 ml single IM injection into the deltoid or vastus Thrombocytopenia or bleeding disorders, acute
Active immunization against typhoid fever in adult and Fever, headache, general aches, malaise, hypersensitivity to any component of the
Typhoid Vaccine Injection - lateralis, may reimmunize with 0.5 ml IM every 2 years febrile illness, children less than 2 years, Chemotherapeutic agents
child more than 2 years nausea and itching. Very rarely, allergic vaccine, immunodeficiency, pregnancy and
if needed immunocompromised patients
reactions including anaphylactoid reactions lactation
Swelling, injection site reaction, rash, electrolyte
imbalance, abdominal pain, nausea, vomiting,
Abnormal bleeding, hypersensitivity to
headache, pain, breast tenderness, cyst of
Gynaecologic and endocrinologic evaluation before urofollitropin, infertility of etiology other than
To be individualized. 75 IU-150 IU daily and maybe ovary, hypertrophy of ovary, fever,
initiation of therapy, ovarian enlargement risk, anovulation, organic intracranial lesion, ovarian
Urofollitropin 150 IU Injection Folliova Stimulation of follicular growth in infertile women increased or decreased by up to 75 IU/day at 7 or 14 thromboembolic disorder, ectopic pregnancy, Not known
potential for multiple births, risk of ovarian cysts/ enlargement of undetermined origin,
day intervals if necessary ovarian hyperstimulation syndrome, Torsion of
hyperstimulation syndrome (OHSS) pregnancy, primary ovarian failure, uncontrolled
ovary, related to ovarian enlargement, disorder
thyroid or adrenal failure
of respiratory system, atelectasis, acute
Swelling, injection site reaction, rash, electrolyte
imbalance, abdominal pain, nausea, vomiting,
Abnormal bleeding, hypersensitivity to
headache, pain, breast tenderness, cyst of
Gynaecologic and endocrinologic evaluation before urofollitropin, infertility of etiology other than
To be individualized. 75 IU-150 IU daily and maybe ovary, hypertrophy of ovary, fever,
initiation of therapy, ovarian enlargement risk, anovulation, organic intracranial lesion, ovarian
Urofollitropin 75 IU Injection Folliova Stimulation of follicular growth in infertile women increased or decreased by up to 75 IU/day at 7 or 14 thromboembolic disorder, ectopic pregnancy, Not known
potential for multiple births, risk of ovarian cysts/ enlargement of undetermined origin,
day intervals if necessary ovarian hyperstimulation syndrome, Torsion of
hyperstimulation syndrome (OHSS) pregnancy, primary ovarian failure, uncontrolled
ovary, related to ovarian enlargement, disorder
thyroid or adrenal failure
of respiratory system, atelectasis, acute
ADULT: Acute pulmonary embolism: IV loading dose
4400 iu/kg over 10 mins, maintenance 4400 iu/kg/hour Surgery within 10 days. Intra arterial diagnostic
for 12 hours. Peripheral vascular occlusion: infuse 2500 procedure within 10 days. Ulcerative wounds.
Treatment of thromboembolic disease such as
iu/ml into clot at a rate of 4000 iu/min for 2 hours. This Recent trauma with possibility of internal injuries. Hypersensitivity to urokinase products,
mycocardial infarction, peripheral artery occlusion,
Urokinase 6000 IU Injection Urokinase may be repeated up to 4 times. Hyphaema: 5000 IU in Pregnancy and the first 10 days of the postpartum Bleeding, hypotension, epistaxis, bronchospasm cerebrovascular accident, internal bleeding, Heparin, oral anticoagulants
pulmonary embolism, retinal artery thrombosis and
2 ml saline solution is injected and withdrawn period. Ulcerative colitis, diverticulitis or an active surgery or trauma within 10 days
other ophthalmologic use
repeatedly over the iris. If residual clot remains, leave bleeding lesion of the gastrointestinal or
0.3ml in the anterior chambers for 24-48 hours to genitourinary tract
facilitate futher dissolution
Radio-opaque stones, pregnancy, non-
Absorption decreased by cholestyramine,
10-15 mg/kg daily in 2 to 4 divided doses usually for 3 Hepatic enzymes (alanine and aspartate functioning gall bladder, chronic liver disease,
colestipol or aluminium hydroxide containing
Ursodeoxycholic Acid 250 mg Cholestatic liver diseases (eg. primary biliary cirrhosis, months to 2 years. If there is no decrease in stone size transaminase) should be monitored upon the Nausea, vomiting, diarrhoea, gallstone peptic ulceration, inflammatory diseases and
Ursofalk antacids. Should not be used with drugs such as
Capsule primary cholangitis etc) after 18 months, further treatment seems not to be initiation of therapy and thereafter as indicated by calcification, pruritus, pulpy stools other conditions of the small intestine, colon and
oestrogenic hormones that increase bile
useful the particular clinical circumstances liver which interfere with enterohepatic
cholesterol
circulation of bile salts
Risk of hypotension in sodium and or volume Pregnancy, lactation, severe hepatic impairment, Concomitant treatment with potassium sparing
depleted patients, renal artery stenosis, renal and Headache, dizziness, fatigue, hypokalaemia, biliary cirrhosis and cholestasis, anuria, severe diuretics or potassium supplements may
Valsartan 160 mg and Hypertension in patients who cannot tolerate ACE
Co-Diovan 1 tablet once daily liver disease, disturbance of serum electrolyte hyperuricaemia and other electrolyte imbalance, renal impairment. Refractory hypokalaemia, increase serum potassium levels. Caution if
Hydrochlorothiazide 25 mg Tablet inhibitors because of cough
balance. Caution when driving or operating orthostatic hypotension and increased lipids hyponatraemia, hypercalcaemia and combined with other antihypertensives or lithium
machinery symptomatic hyperuricaemia (serum lithium monitoring)
Volume depletion, unilateral renal artery stenosis,

monitor serum potassium concentrations, severe
i) 80 or 160 mg once daily. May be increased to 320 mg Headache, dizziness, viral infection, neutropenia,
heart failure, aortic or mitral valve stenosis, coronary
Patients who cannot tolerate ACE inhibitors because of once daily. ii) 40 mg twice daily. Uptitration to 80 mg upper respiratory tract infection, hyperkalaemia, Potassium-sparing diuretics, potassium
artery disease, hypertrophic cardiomyopathy,
Valsartan 160 mg Tablet Diovan cough, in i) Hypertension ii) Heart failure iii) Post and 160 mg twice daily. Max: 320 mg in divided doses. cough, diarrhoea, abdominal pain, back pain, Hypersensitivity to valsartan products supplements, cimetidine, co-trimoxazole, ACE
elderly, severe renal impairment, biliary cirrhosis or
myocardial infarction iii) 20 mg twice daily. Uptitration to max of 160 mg twice fatigue, asthenia, oedema, syncope, rhinitis, inhibitors, phenobarbital, ketoconazole
obstruction. Combination of ACE inhibitor, â-blocker
daily. sinusitis, nausea, pharyngitis and arthralgia
may impair ability to drive or operate machinery,
pregnancy, lactation
Risk of hypotension in sodium and or volume Pregnancy, lactation, severe hepatic impairment, Concomitant treatment with potassium sparing
depleted patients, renal artery stenosis, renal and Headache, dizziness, fatigue, hypokalaemia, biliary cirrhosis and cholestasis, anuria, severe diuretics or potassium supplements may
Valsartan 80 mg and Hypertension in patients who cannot tolerate ACE
Co-Diovan 1 tablet once daily liver disease, disturbance of serum electrolyte hyperuricaemia and other electrolyte imbalance, renal impairment. Refractory hypokalaemia, increase serum potassium levels. Caution if
Hydrochlorothiazide 12.5 mg Tablet inhibitors because of cough
balance. Caution when driving or operating orthostatic hypotension and increased lipids hyponatraemia, hypercalcaemia and combined with other antihypertensives or lithium
machinery symptomatic hyperuricaemia (serum lithium monitoring)
Volume depletion, unilateral renal artery stenosis,

monitor serum potassium concentrations, severe
i) 80 or 160 mg once daily. May be increased to 320 mg Headache, dizziness, viral infection, neutropenia,
heart failure, aortic or mitral valve stenosis, coronary
Patients who cannot tolerate ACE inhibitors because of once daily. ii) 40 mg twice daily. Uptitration to 80 mg upper respiratory tract infection, hyperkalaemia, Potassium-sparing diuretics, potassium
artery disease, hypertrophic cardiomyopathy,
Valsartan 80 mg Tablet Diovan cough, in i) Hypertension ii) Heart failure iii) Post and 160mg twice daily. Max: 320 mg in divided doses. cough, diarrhoea, abdominal pain, back pain, Hypersensitivity to valsartan products supplements, cimetidine, co-trimoxazole, ACE
elderly, severe renal impairment, biliary cirrhosis or
myocardial infarction iii) 20 mg twice daily increased over several weeks to fatigue, asthenia, oedema, syncope, rhinitis, inhibitors, phenobarbital, ketoconazole
obstruction. Combination of ACE inhibitor, â-blocker
160mg twice daily if tolerated. sinusitis, nausea, pharyngitis and arthralgia
may impair ability to drive or operate machinery,
pregnancy, lactation
Slow IV infusion, ADULT: 500 mg over at least 60

minutes every 6 hours or 1 g over at least 100 minutes Increased risk of ototoxicity with loop diuretics,
Thrombophlebitis, febrile reactions with rigor
every 12 hours. NEONATE up to 1 week, 15 mg/kg Rapid infusion-related reactions. Hearing loss, renal aminoglycosides. Increased risk of
Vancomycin HCl 500 mg Injection Vancocin Only for the treatment of MRSA and CAPD peritonitis during administration, nephrotoxicity, ototoxicity, Known hypersensitivity to this antibiotic
initially, then 10 mg/kg every 12 hours. INFANT 1 - 4 impairment, pregnancy and lactation nephrotoxicity with aminoglycosides and
nausea and vomitting
weeks, 15 mg/kg initially then 10 mg/kg every 8 hours. cephalosporins
CHILD over 1 month, 10 mg/kg every 6 hours
Serious neuropsychiatric symptoms, severe renal
impairment, smoking cessation may alter the
0.5 mg once daily for days 1 through 3, then 0.5 mg Constipation, flatulence, nausea, vomiting,
pharmacokinetics or pharmacodynamics of some Hypersensitivity to varenicline or any other Cimetidine, insulin, theophylline, warfarin,
Varenicline Tartrate 0.5 mg Tablet Champix® Smoking cessation treatment twice daily for days 4 through 7, then 1 mg twice daily; dream disorder, headache, insomnia, psychiatric
drugs including theophylline, warfarin and insulin, product component transdermal nicotine
duration of treatment is 12 weeks disorders (depression), suicidal thoughts
intolerable nausea; dose reduction should be
considered
Serious neuropsychiatric symptoms, severe renal
impairment, smoking cessation may alter the
0.5 mg once daily for days 1 through 3, then 0.5 mg Constipation, flatulence, nausea, vomiting,
pharmacokinetics or pharmacodynamics of some Hypersensitivity to varenicline or any other Cimetidine, insulin, theophylline, warfarin,
Varenicline Tartrate 1 mg Tablet Champix® Smoking cessation treatment twice daily for days 4 through 7, then 1 mg twice daily; dream disorder, headache, insomnia, psychiatric
drugs including theophylline, warfarin and insulin, product component transdermal nicotine
duration of treatment is 12 weeks disorders (depression), suicidal thoughts
intolerable nausea; dose reduction should be
considered
i) Health staff working with children, pregnant women,
transplant, cancer and immunocompromised patients
who are at high risk of contacting varicella and
Transfusion and administration of gamma-
transmitting it to at risk patients ii) Transplant patients
globulin preparations: The vaccine may not be
or candidates who are: a) Immunocompetent and not
effective in those receiving blood or gamma-
receiving immunosuppressant drugs, do not have graft
globulin preparation within 3 month before
versus host disease 2 years or more after transplant b)
vaccination. Vaccination of such individuals
Susceptible to Varicella-Zoster virus at least 3 weeks
Discontinue maintenance chemotherapy equal or should be delayed until equal or more than 3
before grafting iii) Children: a) with impaired humoral
less than 1 week prior to injection and recommence months has elapsed. For those receiving high
immunity b) HIV-infected children more than 12 months
therapy after equal or more than 1 week after dose gamma-globulin therapy, ie equal or more
of age, in CDC class N1 (asymptomatic) or A1 (mildly
injection. Malignant solid tumours, women of child- than 200 mg/kg, eg patients with Kawasaki
symptomatic) with age specific CD4 more than 25% c)
bearing potential should practise adequate disease or acute immune thrombocytopenic
with conditions that require systemic steroid therapy
contraceptive measures 1 month prior to vaccination purpura (ITP), vaccination should be delayed
less than 2 mg/kg body weight or a total of 20 mg/day Reinforcement therapy for leukaemia or
ADULT and CHILD 13 years or more: 2 doses of 0.5 ml and 2 month after vaccination. Cardiovascular, until equal or more than 6 months has elapsed. If
Varicella Virus Vaccine Live Okavax, varivax, of prednisolone or its equivalent. [Those receiving high Fever, rash, urticaria, erythema, pruritus. Rarely, extensive therapy using strong
SC injection separated by 4 - 8 weeks apart. CHILD 12 kidney, liver, haematological or developmental gamma-globulin is administered within 14 days
Attenuated Injection varilrix doses of systemic steroids at 2 mg/kg body weight or local reaction, anaphylactoid symptoms immunosuppressives. Acute myelogenous
months - 12 years: 0.5ml SC as a single dose abnormalities. History of seizures, diagnosed after administration of the vaccine, the vaccine
more of prednisolone for more than 2 weeks may be leukaemia or malignant lymphoma
immunodeficiency states, abnormal immune system may not be effective. Such individuals should be
vaccinated after steroid therapy has been discontinued
function. Concomitant immunosupressive therapy. re-vaccinated equal or more than 3 months after
for at least three months] iv) Acute lymphoblastic
Vaccine may not effective in patients receiving blood the initial vaccination. Other live vaccine
leukemia (ALL) patients with negative history of
or gamma-globulin preparation within 3 month prior preparations: Those receiving other live
varicella who:- a) are 12 months to 17 years of age b)
to vaccination. Other live viral vaccines should only vaccines, eg oral polio, measles, mumps,
have leukemia in remission for at least 12 months c)
be given equal or more than 4 weeks after Okavax rubella, BCG or yellow fever vaccine, are
have a peripheral blood lymphocyte count 700 cells/
advised to wait until equal or more than 4 weeks
mm3 or more. [If platelet count of greater 100,000/mm3
has elapsed before being vaccinated.
within 24 hours of vaccination are not being submitted
Incompatibilities: The vaccine should not be
to radiotherapy. Chemotherapy should be withheld for
mixed with other vaccines or medications in the
seven days before and after immunisation] v)
same syringe
Susceptible subjects in clinical trials who will be
submitted for chemotherapy vi) Children and
susceptible patients on chronic dialysis
Pallor, nausea, belching, abdominal cramps,
i) 5 - 20 units SC or IM every 4 hours ii) 20 units in 100 -
Heart failure, migraine, epilepsy, asthma or other hypersensitivity reaction, sweating, urticaria, Hypersensitivity to vasopressin, vascular Carbamazepine, chlorpropamide, clofibrate,
i) Pituitary diabetes insipidus ii) Oesophageal variceal 200 ml 5% dextrose saline over 15 minutes as infusion
Vasopressin 20 units/ml Injection Pitressin conditions which might be exacerbated by fluid gangrene, arrhythmias, angina and disease especially coronary artery disease, urea, fludrocortisone, tricyclic antidepressants,
bleeding which may be repeated after at intervals of 1 - 2 hours.
retention, renal impairment. Avoid fluid overload bronchoconstriction, anaphylaxis, cardiac arrest chronic nephritis and pregnancy (3rd trimester) noradrenaline, lithium, heparin and alcohol
Maximum: 4 doses
or shock
Increased effect by anaesthesia, non-
depolarising muscle relaxants, prior
administration of suxamethonium,
aminoglycoside and polypeptide antibiotics,
ADULT: 80 - 100 mcg/kg IV. Maintenance 20 - 30 Neuromuscular disease, severe obesity, after
diuretics, beta-adrenergic blockers, thiamine,
Vecuronium Bromide 10 mg/10 ml As an adjunct in anaesthesia to produce skeletal mcg/kg acording to response. NEONATE and INFANT poliomyelitis. Electrolyte imbalances, dehydration, Known former anaphylactic reactions to
Norcuron Anaphylactic reactions (rare) MAOIs, quinidine, protamine, imidazole,
Injection muscle relaxation up to 4 months: Initially 10 - 20 mcg/kg, then acidosis. Renal insufficiency and liver disorders. vecuronium or bromide ion
metronidazole, alpha-adrenergic blockers.
incremental dose to achieve response Myasthenia gravis, Eaton-Lambert syndrome
Decreased effect by neostigmine,
corticosteroids, noradrenaline, theophylline,
azathioprine, potassium chloride, sodium
chloride, edrophonium
Increased effect by anaesthesia, non-
depolarising muscle relaxants, prior
administration of suxamethonium,
aminoglycoside and polypeptide antibiotics,
ADULT: 80 - 100 mcg/kg IV. Maintenance 20 - 30 Neuromuscular disease, severe obesity, after
diuretics, beta-adrenergic blockers, thiamine,
Vecuronium Bromide 4 mg/ml As an adjunct in anaesthesia to produce skeletal mcg/kg acording to response. NEONATE and INFANT poliomyelitis. Electrolyte imbalances, dehydration, Known former anaphylactic reactions to
Norcuron Anaphylactic reactions (rare) MAOIs, quinidine, protamine, imidazole,
Injection muscle relaxation up to 4 months: Initially 10 - 20 mcg/kg, then acidosis. Renal insufficiency and liver disorders. vecuronium or bromide ion
metronidazole, alpha-adrenergic blockers.
incremental dose to achieve response Myasthenia gravis, Eaton-Lambert syndrome
Decreased effect by neostigmine,
corticosteroids, noradrenaline, theophylline,
azathioprine, potassium chloride, sodium
chloride, edrophonium
Clozapine, dexfenfluramine, droperidol,
Activation of mania/hypomania, changes in appetite Abnormal ejaculation, anorgasmia, impotence,
fenfluramine, haloperidol, linezolid, lithium,
i), ii) & iii) ADULT: 75 mg once daily. May increase dose or weight, glaucoma, history of seizure, anorexia, constipation, weight loss, diarrhoea,
metoclopramide, moclobemide, NSAIDs,
by 75 mg/day every 4 days to a maximum dose of 225 hyponatraemia, syndrome of inappropriate dyspepsia, anxiety, dizziness, insomnia, Recent or concomitant use of MAOIs, risk of
procarbazine, selegiline, thioridazine, tramadol,
Venlafaxine HCl 150 mg Extended i) Depression ii) Generalized anxiety disorder iii) Social mg/day iv) 37.5 mg/day for the first 4-7 days after which antidiuretic hormone syndrome (SIADH), patients nervousness, somnolence, tremor, asthenia, potentially life-threatening serotonin syndrome
Efexor XR trifluoperazine, amoxicillin, aspirin, celecoxib
Release Capsule anxiety disorder (social phobia) iv) Panic disorder the dose should be increased to 75 mg once daily. with recent myocardial infarction or unstable heart abnormal bleeding, activation of mania, suicide hypersensitivity to venlafaxine hydrochloride or
,diclofenac, etoricoxib, ginkgo, NSAIDs, jujube
CHILD and ADOLESCENT under 18 years not disease, sustained hypertension, suicidal ideation, ideation, hepatitis, hypertension, hyponatraemia, any other component of the product
,ketoprofen, ketorolac, mefenamic acid,
recommended lactation, elderly, renal and liver function impairment, seizures, sweating symptom, nausea, dream
meloxicam, mirtazapine, phenylbutazone,
avoid abrupt discontinuation disorder, headache, blurred vision
procarbazine, sulindac, zolpidem
Clozapine, dexfenfluramine, droperidol,
Activation of mania/hypomania, changes in appetite Abnormal ejaculation, anorgasmia, impotence,
fenfluramine, haloperidol, linezolid, lithium,
i), ii) & iii) ADULT: 75 mg once daily. May increase dose or weight, glaucoma, history of seizure, anorexia, constipation, weight loss, diarrhoea,
metoclopramide, moclobemide, NSAIDs,
by 75 mg/day every 4 days to a maximum dose of 225 hyponatraemia, syndrome of inappropriate dyspepsia, anxiety, dizziness, insomnia, Recent or concomitant use of MAOIs, risk of
procarbazine, selegiline, thioridazine, tramadol,
Venlafaxine HCl 75 mg Extended i) Depression ii) Generalized anxiety disorder iii) Social mg/day iv) 37.5 mg/day for the first 4-7 days after which antidiuretic hormone syndrome (SIADH), patients nervousness, somnolence, tremor, asthenia, potentially life-threatening serotonin syndrome
Efexor XR trifluoperazine, amoxicillin, aspirin, celecoxib
Release Capsule anxiety disorder (social phobia) iv) Panic disorder the dose should be increased to 75 mg once daily. with recent myocardial infarction or unstable heart abnormal bleeding, activation of mania, suicide hypersensitivity to venlafaxine hydrochloride or
,diclofenac, etoricoxib, ginkgo, NSAIDs, jujube
CHILD and ADOLESCENT under 18 years not disease, sustained hypertension, suicidal ideation, ideation, hepatitis, hypertension, hyponatraemia, any other component of the product
,ketoprofen, ketorolac, mefenamic acid,
recommended lactation, elderly, renal and liver function impairment, seizures, sweating symptom, nausea, dream
meloxicam, mirtazapine, phenylbutazone,
avoid abrupt discontinuation disorder, headache, blurred vision
procarbazine, sulindac, zolpidem
Constipation, dizziness, nausea or vertigo,
headache, hypotension, ankle oedema, flushing,
fatigue, nervousness, paraesthesia,
Cardiovascular shock, complicated acute
First degree AV block, bradycardia, hypotension. bradycardiac arrhythmias, dyspnoea, raised
myocardial shock, severe conduction disorders Increased risk of myocardial depression with
May impair ability to drive or operate machinery. prolactin levels, single cases of galactorrhoea,
i) Supraventricular tachyarrhythmias (SVT) prophylaxis ADULT: 40 - 80 mg 3-4 times daily. In oral long term (2nd and 3rd degree AV block, SA block), sick beta-blockers or inhalation anaesthetic. May
Verapamil HCl 40 mg Tablet Isoptin Pregnancy, lactation. Severe hepatic impairment. myalgia, arthralgia, allergic skin reactions,
ii) angina therapy, max: 480 mg daily sinus syndrome, heart failure, atrial increase plasma digoxin concentration and
Slows down markedly the elimination of alcohol and purpura, photosensitisation dermatitis,
fibrillation/flutter and simultaneous preexcitation plasma cyclosporin concentration
prolongs the duration of alcohol gynaecomastia, reversible increase in
syndrome, myasthenia gravis
transaminases and or alkaline phosphatase,
gingival hyperplasia, tachycardia, palpitations,
impotence, tinnitus, tremor, heart failure
Constipation, dizziness, nausea or vertigo,
headache, hypotension, ankle oedema, flushing,
fatigue, nervousness, paraesthesia, Effects enhanced by beta-blockers,
bradycardiac arrhythmias, dyspnoea, raised antiarrhythmics or inhalation anaesthetic. May
Cardiac failure, complicated acute myocardial prolactin levels, single cases of galactorrhoea, Marked bradycardia, sick-sinus syndrome. 2nd intensify effects of other antihypertensives.
5 mg by slow IV. The dose can be repeated after 5 - 10
Verapamil HCl 5 mg/2 ml Injection Isoptin Supraventricular tachycardia infarction, atrial fibrillation with Wolff-Parkinson- myalgia, arthralgia, allergic skin reactions, or 3rd degree AV block. Chronic heart failure, Lithium (attenuated by verapamil, enhanced
mins. Recommended max. total dose : 15 mg
White syndrome, hepatic impairment purpura, photosensitisation dermatitis, cardiogenic shock. Pregnancy neurotoxicity). Increases plasma level of
gynaecomastia, reversible increase in cyclosporin, theophylline, digoxin,
transaminases and or alkaline phosphatase, carbamazepine
gingival hyperplasia, tachycardia, palpitations,
impotence, tinnitus, tremor, heart failure
Intrathecal administration can be fatal. Should not be
ADULT: Lung cancer - 6 mg/m2 (maximum 10 mg) on injected into an extremity with impaired circulation. Myelosuppression, nausea, vomiting, anorexia,
Hodgkin's disease, choriocarcinoma resistant to other Hypersensitivity to vinblastine. Pregnancy, Mitomycin C, phenytoin. Drugs which inhibit
Day 1. Hodgkin's disease- refer to protocol. CHILD: Patients carefully monitored for infection until white generalized fatigue, constipation, alopecia,
Vinblastine Sulphate 10 mg Injection Velbe chemotherapeutic agents, non-small cell lung cancer, lactation. Leukopenia, presence of bacterial cytochrome P450 enzymes, voriconazole,
Usual weekly dose: 6 mg/m2 weekly or 3 weekly cell count has return to normal levels if leukopenia dermatitis, vesicant, neurotoxicity, syndrome of
Langerhans cell histiocytosis infection itraconazole
depending on protocol with less than 2000 white blood cells per mm3 inappropriate secretion of anti-diuretic hormone
occurs following dose
Sensorimotor neuropathy, autonomic neuropathy

(severe constipation, ileus, urinary retention and
i) ADULT: 1.4 mg/m2 weekly (maximum 2 mg weekly)
incontinence), cranial nerve dysfunction If used together with L-asparaginase, L-
ii) Refer to protocol iii) 1.4 mg/m2 weekly (maximum 2 Hypersensitivity to vincristine. Pregnancy,
i) Solid tumours ii) Gestational trophoblastic disease iii) Pre-existing neuropathy or neuromuscular disease. (hoarseness, diplopia, facial weakness), asparaginase should be given 12-24 hours after
mg weekly) iv) 0.4 mg/m2 IV continuous infusion on lactation, Charcot-Marie-Tooth syndrome. Fatal if
Vincristine Sulphate 1 mg Injection Oncovin Non-Hodgkin's lymphoma iv) Multiple myeloma v) Dose adjustment needed if impaired liver function, myelosuppression, alopecia. Vesicant, rash, vincristine injection. Digoxin, paclitaxel, cisplatin,
days 1 - 4 v) Refer to protocol. CHILD: 1 mg/m2 to 2 given intrathecally. NOT FOR INTRATHECAL
Acute lymphoblastic leukemia elderly patients. Avoid extravasation abdominal pain, SIADH, hypersensitivity, pain in methotrexate, nifedipine, etoposide, isoniazid,
mg/m2 weekly according to protocol (0.05 mg/kg for USE
jaws, bone, limb or parotid gland, depression, melphalan, metronidazole, verapamil, phenytoin
infants less than 10kg)
confusion, nausea, vomiting, diarrhoea,
myelosupression usually mild
Myelosuppression, granulocytopenia, peripheral
Pre-existing myelosuppression, neuropathy, liver or
i) First line treatment in non-small cell lung cancer in Strictly IV 25 - 30 mg/m2 diluted in saline solution, neuropathy, nausea, vomiting, diarrhoea,
renal insufficiency. Extravasation causing local Hypersensitivity to vinorelbine, granulocytopenia, Cisplatin, mitomycin C, voriconazole,
Vinorelbine 10 mg Injection Navelbine combination with cisplatin/ifosfomide ii) Metastatic infused over 6 - 10 minutes, administered weekly or alopecia. Diminished marrow reserve,
tissue necrosis and or thrombophlebitis. Intrathecal pregnancy, lactation itraconazole
breast cancer day 1, 8 every 3 weeks constipation, paralytic ileus, elevation of liver
administration can be fatal
enzymes, fatigue
Myelosuppression, granulocytopenia, peripheral
Pre-existing myelosuppression, neuropathy, liver or
i) First line treatment in non-small cell lung cancer in Strictly IV 25 - 30 mg/m2 diluted in saline solution, neuropathy, nausea, vomiting, diarrhoea,
renal insufficiency. Extravasation causing local Hypersensitivity to vinorelbine, granulocytopenia, Cisplatin, mitomycin C, voriconazole,
Vinorelbine 50 mg Injection Navelbine combination with cisplatin/ifosfomide ii) Metastatic infused over 6 - 10 minutes, administered weekly or alopecia. Diminished marrow reserve,
tissue necrosis and or thrombophlebitis. Intrathecal pregnancy, lactation itraconazole
breast cancer day 1, 8 every 3 weeks constipation, paralytic ileus, elevation of liver
administration can be fatal
enzymes, fatigue
Hypercalcaemia, nephrotoxicity, nausea, Persons with hypervitaminosis A, oral
vomiting, constipation, anaemia, polydipsia, preparations are not indicated for treating
Take care to ensure correct dose to infants, monitor
polyuria, hypoprothrombinaemia, seizures, Vitamin A deficiency in persons with Phenobarbital, phenytoin, anticoagulants,
Not more than 10 ml daily, allowance being made for plasma calcium and creatinine during dosage
Vitamin A & D (Cod Liver Oil) - Prevention of ricketts drowsiness, irritability, headache, insomnia, malabsorption syndromes etiologic for this cholestyramine, minocycline, thiazides and
Vitamin D obtained from other sources titration, pregnancy, patient with arteriosclerosis,
somnolence, severe depression, psychosis and deficiency, hypercalcaemia, metastatic related diuretics
heart disease or renal stones
chronic liver damage, gingivitis, hepatotoxicity, calcification, hypersensitivity to vitamin A, vitamin
alopecia, osteoporosis D toxicity and hypersensitivity
Hypercalcaemia, nephrotoxicity, nausea, Persons with hypervitaminosis A, oral
vomiting, constipation, anaemia, polydipsia, preparations are not indicated for treating vitamin
Take care to ensure correct dose to infants, monitor
0.06 - 0.6ml (2,500-25,000 IU of Vitamin A and 250- polyuria, hypoprothrombinaemia, seizures, A deficiency in persons with malabsorption Phenobarbital, phenytoin, anticoagulants,
Vitamin A & D Concentrate 25,000 plasma calcium and creatinine during dosage
- Prevention of ricketts 2,500 IU of D) daily, allowance being made for A and D drowsiness, irritability, headache, insomnia, syndromes etiologic for this deficiency, cholestyramine, minocycline, thiazides and
units/0.6ml Liquid titration, pregnancy, patient with arteriosclerosis,
obtained from other sources somnolence, severe depression, psychosis and hypercalcaemia, metastatic calcification, related diuretics
heart disease or renal stones
chronic liver damage, gingivitis, hepatotoxicity, hypersensitivity to vitamin A, vitamin D toxicity
alopecia, osteoporosis and hypersensitivity
Massive overdose can cause rough skin, dry Cholestyramine decreases absorption of vitamin
Children with measles malnutrition and serious
i) 0-5 months, 50,000 IU ii) 6-11 months, 100,000 IU iii) hair, enlarge liver and raised erythrocyte Hypersensitivity to Vitamin A, hypervitaminosis A, retinoids may have additive adverse effects,
Vitamin A 50,000 IU Capsule - infections. Category C can use this drug for Orang Asli Pregnancy
1-5 years, 200,000 IU. Frequency twice daily sedimentation rate and raised serum calcium A, pregnancy (dose exceeding RDA) neomycin and mineral oil may also interfere with
and in Sabah
and serum alkaline phosphatase concentrations vitamin A absorption
Not for treatment of pernicious anaemia or other Risk of anaphylactic shock. Allergy to
Allergy to cobalamins, megaloblastic anaemia of
Vitamin B Complex 10 ml Injection - Prophylaxis and treatment of vitamin B deficiency 1-2 ml daily by IM megaloblastic anaemias where vitamin B12 is cobalamins, megaloblastic anaemia of Pyridoxine reduces the effect of levodopa
pregnancy
deficient pregnancy
Not for treatment of pernicious anaemia or other
Peripheral neuropathies (long term Allergy to cobalamins, megaloblastic anaemia of
Vitamin B Complex Tablet - Prophylaxis and treatment of vitamin B deficiency 1-2 tablets daily megaloblastic anaemias where vitamin B12 is Pyridoxine reduces the effect of levodopa
administration of large doses of pyridoxine) pregnancy
deficient
Photolysis. Repeated injection at the same site
should be avoided. Care should be exercised when
administering to neonates, premature infants, infants
For deficiency or raised requirement of Vitamin B1, B6, Mild cases: 1 ampoule given by IM 2-3 times weekly. and children. The course of nerves should be Pain and induration at site of injection, headache, High vitamin B6 dose decreases action of
Vitamin B1, B6, B12 Injection Neurobion Not known
B12 Severe cases: 1 ampoule daily avoided for the site of injection. If the patient sweating or hot sensation Levodopa
complaints of pain or if blood reflux occurs when the
needle is stuck, withdraw it immediately and try at a
different site
For deficiency or raised requirement of Vitamin B1, B6, Discontinue medication if there is no response after Anorexia, nausea or diarrhoea, skin rash and High vitamin B6 dose decreases action of
Vitamin B1, B6, B12 Tablet Neurobion 1 - 3 tablets 3 times daily swallowed unchewed Patients treated with levodopa
B12 taking orally for several months hypersensitivity Levodopa
For all types of severe chemical corneal burns
Vitamin C 10% Eye Drops - 1 to 4 times daily depending on severity of case Not known Not known Hypersensitivity to vitamin C products Not known
especially acid and alkali burns
To improve appetite and growth. Neurasthenia, nausea
Vitamin E, B12, B6, Nicotinamide Thrombophlebitis, anorexia, nausea or High vitamin B6 dose decreases action of
Fundamin-E and vomiting in pregnancy, radiation sickness and 1 - 2 tablet daily Vitamin K deficiency, necrotizing enterocolitis Hypersensitivity to drug or any components
Tablet diarrhoea, skin rash and hypersensitivity Levodopa, anticoagulants, cholestyramine
neuritis due to isoniazid therapy and alcoholism
IV or IM administration only when necessary (risk of
anaphylaxis). Hypersensitivity reactions possible Anaphylactic reactions during intravenous Hypersensitivity to Vitamin K, menadione (K3)
Decreases the effects of oral anticoagulants,
Vitamin K1 1 mg/ml Injection Konakion Vitamin K deficiency in neonates 1 mg given by IM or IV even at first administration. The anticoagulant action administration, dermatitis at injection site, administration in glucose-6-phosphate
fatty foods
of heparin not counteracted by phytomenadione haemolytic anaemia dehydrogenase deficiency
Vitamin K
anaphylaxis). Hypersensitivity reactions possible Anaphylactic reactions during intravenous Hypersensitivity to Vitamin K, menadione (K3)
Haemorrhage associated with hypoprothrombinaemia 0.5 - 20 mg by very slow IV at a rate not exceeding 1 Decreases the effects of oral anticoagulants,
Vitamin K1 10 mg/ml Injection Konakion even at first administration. The anticoagulant action administration, dermatitis at injection site, administration in glucose-6-phosphate
caused by overdose of anticoagulants mg per minute fatty foods
of heparin not counteracted by phytomenadione haemolytic anaemia dehydrogenase deficiency
Vitamin K. Reduce dose in elderly, liver impairment
Healthy neonate 2 mg orally at birth or soon after

followed by 2 mg at 4 - 7 days. Exclusively breastfed
anaphylaxis). Hypersensitivity reactions possible
baby, in addition, 2 mg orally at monthly intervals until Anaphylactic reactions during intravenous Hypersensitivity to Vitamin K, menadione (K3)
Vitamin K1 Mixed Micelle 2 mg/0.2 ml even at first administration. The anticoagulant action Decreases the effects of oral anticoagulants,
Konakion Prevention of bleeding in neonates end of breastfeeding period. Neonate at special risk, 1 administration, dermatitis at injection site, administration in glucose-6-phosphate
Injection of heparin not counteracted by phytomenadione Vit. fatty foods
mg IM/IV at birth or soon after if oral route is not haemolytic anaemia dehydrogenase deficiency
K. Parenteral administration in neonate less than 2.5
suitable. Treatment: 1 mg IV initially. Further doses
kg increased risk of kernicterus
depend on clinical picture and coagulation status
i) Treatment of immunocompromised patients with
progressive, possibly life-threatening infections such as Electrolyte disturbance, cardiomyopathy, Alprazolam, bromazepam, clarithromycin,
Peripheral oedema, rash, diarrhoea, nausea,
invasive aspergillosis, fluconazole-resistant serious Loading dose: 6 mg/kg 12 hourly for first 24 hours. bradycardia, symptomatic arrhythmias, history of QT Co-administration of terfenadine, astemizole, clonazepam, cyclosporine, diazepam, phenytoin,
vomiting, disease of liver, headache, visual
invasive candidiasis, candidiasis of the oesophagus, Maintenance :i) 4 mg/kg 12 hourly ii) 3 mg/kg 12 hourly. interval prolongation. Avoid exposure to sunlight, quinidine, sirolimus, rifampicin, carbamazepine, tacrolimus, warfarin, sulfonylureas, statins,
Voriconazole 200 mg Injection Vfend disturbance, Stevens-Johnson syndrome,
serious fungal infections caused by Scedosporium Dose may be increased to 4 mg/kg 12 hourly if monitor liver function before treatment and during phenobarbitone, efavirenz, ergotamine, benzodiazepines, omeprazole, HIV protease
anaphylactoid reaction, renal failure, jaundice,
species and Fusarium species ii)Prevention of response is inadequate treatment, haematological malignancy, pregnancy dihydroergotamine inhibitors, non-nucleoside reverse transcriptase
blood dyscrasias
breakthrough fungal infections in febrile high-risk (ensure effective contraception during treatment) inhibitors, other CYP2C9 or CYP3A4 substrates
neutropenic patients
ADULT and CHILDREN 12 years and greater and over Peripheral oedema, rash, diarrhoea, nausea,
invasive aspergillosis, fluconazole-resistant serious bradycardia, symptomatic arrhythmias, history of QT Co-administration of terfenadine, astemizole, clonazepam, cyclosporine, diazepam, phenytoin,
40 kg: Loading dose: 400 mg 12 hourly for first 24 vomiting, disease of liver, headache, visual
invasive candidiasis, candidiasis of the oesophagus, interval prolongation. Avoid exposure to sunlight, quinidine, sirolimus, rifampicin, carbamazepine, tacrolimus, warfarin, sulfonylureas, statins,
Voriconazole 200 mg Tablet Vfend hours. Maintenance: 200 - 300 mg 12 hourly. Less than disturbance, Stevens-Johnson syndrome,
serious fungal infections caused by Scedosporium monitor liver function before treatment and during phenobarbitone, efavirenz, ergotamine, benzodiazepines, omeprazole, HIV protease
40 kg: Loading dose: 200 mg 12 hourly for first 24 anaphylactoid reaction, renal failure, jaundice,
species and Fusarium species ii) Prevention of treatment, haematological malignancy, pregnancy dihydroergotamine inhibitors, non-nucleoside reverse transcriptase
hours. Maintenance: 100 - 150 mg 12 hourly blood dyscrasias
ADULT and CHILDREN 12 years and greater and over Peripheral oedema, rash, diarrhoea, nausea,
invasive aspergillosis, fluconazole-resistant serious bradycardia, symptomatic arrhythmias, history of QT Co-administration of terfenadine, astemizole, clonazepam, cyclosporine, diazepam, phenytoin,
40 kg: Loading dose: 400 mg 12 hourly for first 24 vomiting, disease of liver, headache, visual
invasive candidiasis, candidiasis of the oesophagus, interval prolongation. Avoid exposure to sunlight, quinidine, sirolimus, rifampicin, carbamazepine, tacrolimus, warfarin, sulfonylureas, statins,
Voriconazole 50 mg Tablet Vfend hours. Maintenance: 200 - 300 mg 12 hourly. Less than disturbance, Stevens-Johnson syndrome,
serious fungal infections caused by Scedosporium monitor liver function before treatment and during phenobarbitone, efavirenz, ergotamine, benzodiazepines, omeprazole, HIV protease
40 kg: Loading dose: 200 mg 12 hourly for first 24 anaphylactoid reaction, renal failure, jaundice,
species and Fusarium species ii) Prevention of treatment, haematological malignancy, pregnancy dihydroergotamine inhibitors, non-nucleoside reverse transcriptase
hours. Maintenance: 100 - 150 mg 12 hourly blood dyscrasias
Severe to moderate hepatic or renal insufficiency,
concomitant use of antiplatelet drugs or drugs with
ulcerogenic activity. Surgery and dental extraction, Activity potentiated by cimetidine, clofibrate, co-
congestive heart failure. Concurrent use with Haemorrhage, alopecia, fever, gastrointestinal trimoxazole, erythromycin, quinidine,
Initially 10 mg daily for 2 days. Maintenance dose, 3-9 thrombolytic drugs, known or suspected protein C disorders, hypersensitivity reactions, `purple phenylbutazone, sulfonamides, amiodarone,
Treatment and prophylaxis of thromboembolic Haemorrhagic tendencies, pregnancy, blood
Warfarin Sodium 1 mg Tablet Coumadin mg daily according to the INR (taken at the same time deficiency. Moderate to severe hypertension, severe toes'. Occasionally skin necrosis (obese elderly rifampicin, carbamazepine, phenytoin, azole
disorders dyscrasias, hypersensitivity to warfarin products
each day) diabetes, severe allergic or anaphylactic disorders. patients), jaundice, hepatic dysfunction, nausea, antifungals, metronidazole. Drugs which may
Patients with hyperthyroidism or hypothyroidism may vomiting, pancreatitis increase risk of bleeding including aspirin,
have a substantially altered response to warfarin. NSAIDs, dipyridamole, clopidrogel, ticlopidine
Avoid concurrent use with herbal medicines and limit
Vitamin K rich vegetables

Warfarin Sodium 5 mg Tablet Coumadin mg daily according to the INR (taken at the same time deficiency. Moderate-severe hypertension, severe toes'. Occasionally skin necrosis (obese elderly rifampicin, carbamazepine, phenytoin, azole
As a diluent and vehicle for the administration of The stability of any medicament prepared should be
Water for Injection - According to the needs of the patient Not known Not known Not known
medications checked
White Petroleum Anhydrous Liquid Duratears Naturale Keeping the eye lubricated and comfortable during the
Apply a small amount into the eye Do not use if allergic to any of the ingredients Temporary visual disturbance Hypersensitivity Not known
Landin, Mineral Oil Eye Ointment Ocular night
i) 200 mg 3 times/day or 300 mg twice daily until start of
labor. During labour, by IV infusion initially 2 mg/kg over
Anaemia, neutropenia, leucopenia, nausea,
1 hour followed by continuous IV infusion at 1 mg/kg/hr
headache, rash, abdominal pain, fever, myalgia,
until delivery ii) 2 mg/kg orally every 6 hours within 12
Monitor carefully haematological parameters. If paraesthesia, vomiting, insomnia and anorexia.
hours after birth. If unable to receive oral dose: FULL
To reduce the rate of maternal-foetal transmission of anaemia or myelosuppression occurs dose Asthenia, malaise, somnolence, diarrhoea, Abnormally low neutrophil cell count (less than
TERM: 1.5 mg/kg/dose every 6 hours, INFANTS 30 Chronic paracetamol use, potentially nephrotoxic
Zidovudine 1% Injection Retrovir HIV in: i) HIV-positive pregnant women over 14 weeks adjustments are suggested. Patients with pre- dizziness, sweating, dyspnoea, dyspepsia, 0.75 x 109L) or abnormally low Hb levels (less
weeks and less than 35 weeks gestation at birth: 1.5 or myelosuppressive drugs, probenecid
of gestation ii) Their newborn infants existing bone marrow compromise. Pregnancy and flatulence, bad taste, chest pain, loss of mental than 7.5 g/dL)
mg/kg/dose every 12 hours; at 2 weeks of age,
lactation acuity, anxiety, urinary frequency, depression,
advance to 1.5 mg/kg/dose every 8 hours, INFANTS
generalised pain, chills, cough, urticaria, pruritus
less than 30 weeks gestation at birth: 1.5 mg/kg/dose
and flu-like syndrome
every 12 hours; at 4 weeks of age, advance to 1.5
mg/kg/dose every 8 hours
Monitor carefully haematological parameters. If paraesthesia, vomiting, insomnia and anorexia.
i) Management of patients with asymptomatic and i) ADULT: 500 - 600 mg/day in 2 - 3 divided doses.
anaemia or myelosuppression occurs dose Asthenia, malaise, somnolence, diarrhoea, Abnormally low neutrophil cell count (less than
symptomatic (early or advanced) HIV infections with CHILD more than 3 months: 360 - 480 mg/m2 daily in 3 - Chronic paracetamol use, potentially nephrotoxic
Zidovudine 10 mg/ml Syrup Retrovir adjustments are suggested. Patients with pre- dizziness, sweating, dyspnoea, dyspepsia, 0.75 x 109/L) or abnormally low Hb levels (less
CD4 cell counts less than 500 cu. mm. ii) Neonatal 4 divided doses; maximum 200 mg every 6 hours ii) 2 or myelosuppressive drugs, probenecid
existing bone marrow compromise. Pregnancy and flatulence, bad taste, chest pain, loss of mental than 7.5 g/dL)
prophylaxis mg/kg 6 hourly within 12 hours after birth up to 6 weeks
Monitor carefully haematological parameters. If paraesthesia, vomiting, insomnia and anorexia,
i) Management of patients with asymptomatic and i) Adult: 500 - 600 mg/day in 2 - 3 divided doses. Child
anaemia or myelosuppression occurs dose asthenia, malaise, somnolence, diarrhoea, Abnormally low neutrophil cell count (less than
symptomatic (early or advanced) HIV infections with more than 3 months: 360 - 480 mg/m2 daily in 3 - 4 Chronic paracetamol use, potentially nephrotoxic
Zidovudine 100 mg Capsule Retrovir adjustments are suggested. Patients with pre- dizziness, sweating, dyspnoea, dyspepsia, 0.75 x 109/L) or abnormally low Hb levels (less
CD4 cell counts less than 500 cu. mm ii) Neonatal divided doses; maximum 200 mg every 6 hours ii) 2 or myelosuppressive drugs, probenecid
prophylaxis mg/kg 6 hourly within 12 hours after birth up to 6 weeks
Trimethoprim, phenytoin, paracetamol, aspirin,

Headache, malaise, fatigue, gastrointestinal
Advanced cirrhotic liver disease due to chronic Hypersensitivity, patients with abnormally low codeine, morphine, indomethacin, ketoprofen,
Zidovudine 300 mg & Lamivudine 150 HIV infection in combination with at least one other effects, upper abdominal pain, fever, rash,
Combivir ADULT and CHILD over 12 years: 1 tablet twice daily hepatitis B infection. Severe hepatic or renal neutrophil counts or abnormally low haemoglobin naproxen, oxazepam, lorazepam, cimetidine,
mg Tablet antiretroviral drug pancreatitis, peripheral neuropathy, leucopenia,
impairment. Monitor haematological parameters levels clofibrate, dapsone and isoprinosine, potentially
neutropenia, anaemia, thrombocytopenia
nephrotoxic or myelosuppressive drugs, ribavirin

Monitor carefully haematological parameters. If paraesthesia, vomiting, insomnia and anorexia,
i) Management of patients with asymptomatic and
anaemia or myelosuppression occurs dose asthenia, malaise, somnolence, diarrhoea, Abnormally low neutrophil cell count (less than
symptomatic (early or advanced) HIV infections with Chronic paracetamol use, potentially nephrotoxic
Zidovudine 300 mg Tablet Retrovir Adult: 500 - 600 mg daily in 2 - 3 divided doses adjustments are suggested. Patients with pre- dizziness, sweating, dyspnoea, dyspepsia, 0.75 x 109/L) or abnormally low Hb levels (less
CD4 cell counts < 500 cu. mm ii) HIV positive pregnant or myelosuppressive drugs, probenecid
mothers
Hypersensitivity to any component. Avoid contact
Skin protective in various skin conditions such as
Zinc Oxide Cream - Apply 3 times daily or as required with eyes. Not to be applied over deep or puncture Hypersensitivity to any component Weeping dermatoses Not known
nappy rash, eczema and problem skin
wounds, infections or lacerations
Hypersensitivity to any component. Avoid contact
Skin protective in various skin conditions such as
Zinc Oxide Ointment - Apply 3 times daily or as required with eyes. Not to be applied over deep or puncture Hypersensitivity to any component Weeping dermatoses Not known
nappy rash and eczema
wounds, infections or lacerations
QT-interval prolongation, recent myocardial
QT-interval prolongation, neuroleptic malignant
ADULT: Initially 10 mg (every 2 hour) or 20 mg (every 4 Injection site pain, asthenia, headache, infarction, uncompensated heart failure, cardiac Class IA and III antiarrhythmics, drugs that
syndrome, tardive dyskinesia, cardiovascular
Ziprasidone 20 mg/ml Injection Zeldox Acute agitation in schizophrenia hour). Maximum: 40 mg/day. IM administration more hypertension, postural hypertension, diarrhoea, arrhythmias requiring treatment with Class IA prolong QT interval, central nervous system
disease, blood pressure, seizures, central nervous
than 3 days has not been studied nausea, somnolence, dizziness, akathisia and III antiarrhythmic drugs, drugs that prolong drugs/alcohol
system drugs/alcohol, pregnancy, lactation
QT interval
Alopecia, dermatitis, hypokalaemia,
Assess hydration status prior to administration.
hyperkalaemia, hypernatremia, hypocalcemia,
Monitor serum electrolytes and creatinine. Evaluate
hypomagnesemia, hypophosphatemia, shivering,
serum creatinine prior to each administration. If renal
abdominal pain, diarrhoea, nausea, vomiting,
function has deteriorated, the dose should be
arthralgia, bone pain, myalgia, headache,
withheld. Not recomended in patients with bone
paraesthesia, upper tract infection, cough,
metastases with severe renal impairment (serum
dyspnoea, upper respiratory infection, anemia,
i) Treatment of hypercalcaemia of malignancy ii) creatinine greater than 3.0 mg/dl) Severe renal or
4 mg reconstituted and should be given as a 15 neutropenia, thrombocytopenia, nephrotoxicity, Hypersensitivity to zoledronic acid or other Aminoglycosides, other potentially nephrotoxic
Zoledronic Acid 4 mg Injection Zometa Prevention of skeletal related events in patients with hepatic impairment. Patients should be advised to
minutes IV infusion every 3-4 weeks aseptic necrosis of bone and jaw , pleural bisphosphonates, pregnancy, lactation drugs, thalidomide
multiple myeloma involving multiple bone lesions inform the dentist during treatment and if dental
effusion. Rise in body temp, flu-like syndrome,
surgery is foreseen. Caution is advised when
elevation of serum creatinine, renal impairment,
bisphosphonates are administered with
conjunctivitis. Hypersensitivity reactions,
aminoglycosides or other potentially nephrotoxic
hypertension, shortness of breath, dizziness,
drugs, since these agents may have an additive
sleeping disturbances, gastrointestinal reactions,
effect, resulting in a lower serum calcium level for
loss of appetite, local reactions at infusion site,
longer periods than required
rash, pruritus
Alcohol, analgesics, antidepressants,
Obstructive sleep apnoea, acute pulmonary
Depression, drug or alcohol abuse, hepatic Nausea, dizziness, dependence, vertigo, anticoagulants, sedating antihistamines,
insufficiency, respiratory depression, myasthenia
impairment, avoid prolonged use in elderly, lactation, headache, drowsiness, myalgias, dyspepsia, dry antipsychotics, benzodiazepines, central alpha 2
Zolpidem Tartrate 10 mg Tablet Stilnox For treatment of insomnia 10mg initially at bedtime. In ELDERLY, 5 mg initially gravis, severe hepatic impairment, psychotic
renal impairment, abrupt discontinuation, central mouth, lethargy, flu-like symptoms, depression, agonists, ethanol, opiate agonists/antagonists,
illness, pregnancy, breastfeeding,
nervous system effects, drowsiness, hallucination constipation, ataxia, hallucinations itraconazole, sertraline, rifampicin, ritonavir,
hypersensitivity
venlafaxine
Previous hypersensitivity to other neuroleptic agents,
Initial: 20-30 mg/day in 2-3 divided doses. Maximum particularly thioxanthenes, fluphenazine, and
Extrapyramidal syndrome, drowsines, Severe central nervous system depression,
150 mg daily. Usual maintenance dose 20 mg - 50 mg perphenazine. Hepatic or renal disease or
anticholinergic effect, tachycardia, postural coma, blood dyscrasias, phaeocromocytoma. Alcohol, barbiturates and central nervous system
daily. Elderly (or debilitated), initially quarter to half adult cardiovascular disease, pregnancy, breastfeeding,
Zuclopenthixol 20 mg/ml Drops Clopixol Only for psychoses with insight or compliance hypotension, dizziness, tardive dyskinesia, Previous hypersensitivity to zuclopenthixol or depressant, tricyclic antidepressant,
dose. CHILD not recommended. Oral: Zuclopenthixol epileptic or parkinsonian patients or organic brain
urinary retention, disturbed accommodation, clopenthixol. Comatose states, acute alcohol, metoclopramide - increased effect
dihydrochloride: usual maintenance dose: 20-40 syndrome. Patients on long-term therapy should be
tachycardia barbiturate and opiate intoxication. Pregnancy
mg/day; maximum daily dose: 100 mg monitored carefully. May affect ability to drive or
operate machinery
50 - 150 mg repeated after 2 - 3 days if necessary. particularly thioxanthenes, fluphenazine and
Additional dose may be needed 1 - 2 days after the first perphenazine. Hepatic or renal disease or
Only for treatment of agitated and violent patients anticholinergic effect, tachycardia, postural coma, blood dyscrasias, phaeocromocytoma. Alcohol, barbiturates and central nervous system
Zuclopenthixol Acetate 100 mg/2 ml injection. Maximum cumulative dose 400 mg per course cardiovascular disease, pregnancy, breastfeeding,
Clopixol - Acuphase suffering from schizophrenia who are not responding to hypotension, dizziness, tardive dyskinesia, Previous hypersensitivity to zuclopenthixol or depressant, tricyclic antidepressant,
Injection and maximum 4 injections; maximum duration of epileptic or parkinsonian patients or organic brain
the available standard drugs urinary retention, disturbed accommodation, clopenthixol. Comatose states, acute alcohol, metoclopramide - increased effect
treatment 2 weeks. Change to oral dose 2 - 3 days after syndrome. Patients on long-term therapy should be
the last injection. Child not recommended monitored carefully. May affect ability to drive or
operate machinery
50 - 150 mg repeated after 2 - 3 days if necessary. particularly thioxanthenes, fluphenazine and
Additional dose may be needed 1 - 2 days after the first perphenazine. Hepatic or renal disease or
Only for treatment of agitated and violent patients anticholinergic effect, tachycardia, postural coma, blood dyscrasias, phaeocromocytoma. Alcohol, barbiturates and central nervous system
Zuclopenthixol Acetate 50 mg/ml injection. Maximum cumulative dose 400 mg per course cardiovascular disease, pregnancy, breastfeeding,
Clopixol - Acuphase suffering from schizophrenia who are not responding to hypotension, dizziness, tardive dyskinesia, Previous hypersensitivity to zuclopenthixol or depressant, tricyclic antidepressant,
Injection and maximum 4 injections; maximum duration of epileptic or parkinsonian patients or organic brain
the available standard drugs urinary retention, disturbed accommodation, clopenthixol. Comatose states, acute alcohol, metoclopramide - increased effect
treatment 2 weeks. Change to oral dose 2 - 3 days after syndrome. Patients on long-term therapy should be
the last injection. Child not recommended monitored carefully. May affect ability to drive or
operate machinery
particularly thioxanthenes, fluphenazine and
By deep IM injection test dose 100 mg followed after 7 - Severe central nervous system depression,
perphenazine, Hepatic or renal disease or Extrapyramidal syndrome, drowsines,
Only for treatment of agitated and violent patients 28 days by 100 - 200 mg or more followed by 200 - 400 blood dyscrasias, phaeocromocytoma. Previous Alcohol, barbiturates and central nervous system
Zuclopenthixol Decanoate 200 mg/ml cardiovascular disease, pregnancy, breastfeeding, anticholinergic effect, tachycardia, postural
Clopixol Depot suffering from schizophrenia who are not responding to mg at intervals of 2 - 4 weeks adjusted according to hypersensitivity to zuclopenthixol or clopenthixol. depressant, tricyclic antidepressant,
Injection epileptic or parkinsonian patients or organic brain hypotension, dizziness, tardive dyskinesia,
the available standard drugs response. Maximum 600 mg weekly. Child not Comatose states, acute alcohol, barbiturate and metoclopramide - increased effect
syndrome. Patients on long-term therapy should be urinary retention, disturbed accommodation
recommended opiate intoxication. Pregnancy
monitored carefully. May affect ability to drive or
operate machinery

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Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list.

His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Not generally recommended for prolonged use but if

Ibrahim Abdullah - http://sir-ib.blogspot.com

Ibrahim Abdullah - http://sir-ib.blogspot.com

Discontinue in case of dysphagia, odynophagia, Urticaria, myalgia, malaise; nausea, vomiting,

Ibrahim Abdullah - http://sir-ib.blogspot.com

Ibrahim Abdullah - http://sir-ib.blogspot.com

Ibrahim Abdullah - http://sir-ib.blogspot.com

Ibrahim Abdullah - http://sir-ib.blogspot.com

Barbiturate, phenytoin, carbamazepine,

Ibrahim Abdullah - http://sir-ib.blogspot.com

Ibrahim Abdullah - http://sir-ib.blogspot.com

Hypersensitivity to any of the components of

Ibrahim Abdullah - http://sir-ib.blogspot.com

Ibrahim Abdullah - http://sir-ib.blogspot.com

Gastrointestinal disorder or cardiovascular

Gastrointestinal disorder or cardiovascular

Gastrointestinal disorder or cardiovascular

Gastrointestinal disorder or cardiovascular

Gastrointestinal disorder or cardiovascular

Ibrahim Abdullah - http://sir-ib.blogspot.com

Ibrahim Abdullah - http://sir-ib.blogspot.com

Intestinal obstruction, pyloric stenosis or lesions

Nasal irritation, sneezing, epistaxis, rhinorrhea,

Ibrahim Abdullah - http://sir-ib.blogspot.com

Ibrahim Abdullah - http://sir-ib.blogspot.com

Ibrahim Abdullah - http://sir-ib.blogspot.com

Ibrahim Abdullah - http://sir-ib.blogspot.com

Alterations in glucose metabolism, blood dyscrasias Amikacin, angiotensin converting enzyme

Ibrahim Abdullah - http://sir-ib.blogspot.com

Hypovolaemia, complete heart block,

Ibrahim Abdullah - http://sir-ib.blogspot.com

Preexisting neurological or neuromuscular disease

Ibrahim Abdullah - http://sir-ib.blogspot.com

Disorders of calcium metabolism, viral, fungal or Alatrofloxacin, alcuronium, Amphotericin B

Ibrahim Abdullah - http://sir-ib.blogspot.com

Allopurinol, aspirin, chlorothiazide, ciprofloxacin,

Rash, Stevens-Johnson Syndrome, nausea,

Breast feeding, pregnancy, liver or kidney

Rash, Stevens-Johnson Syndrome, nausea,

Ibrahim Abdullah - http://sir-ib.blogspot.com

Myocardial temperature should be monitored during

Ibrahim Abdullah - http://sir-ib.blogspot.com

Drug induced fever, reddening of skin with heat

Ibrahim Abdullah - http://sir-ib.blogspot.com

Ibrahim Abdullah - http://sir-ib.blogspot.com

Ibrahim Abdullah - http://sir-ib.blogspot.com

i) ADULT 0.5-1 g given 3-4 times daily. CHILD half

Surgical hand disinfection: Apply 5ml to clean hands

Ibrahim Abdullah - http://sir-ib.blogspot.com

ADULT 600 mg base stat, 300 mg 6 - 8 hours later and

ADULT : 4 mg every 4 - 6 hours. Maximum 24 mg daily.

Postural hypotension, akathisia, tardive

Ibrahim Abdullah - http://sir-ib.blogspot.com

Ibrahim Abdullah - http://sir-ib.blogspot.com

i) 2 drops every 15 minutes for first 6 hours, then 2

Ibrahim Abdullah - http://sir-ib.blogspot.com

Hypocalcaemia, gastrointestinal tract Hypersensitivity to Clodronate, bisphosphonate

Ibrahim Abdullah - http://sir-ib.blogspot.com

Ibrahim Abdullah - http://sir-ib.blogspot.com

Concurrent use with betamethasone may result