Professional Documents
Culture Documents
WITH NEW DIMENSIONS
AND STRATEGIES:
A VISION FOR 2020 FOR
WOMEN’S HEALTH RESEARCH
OFFICE OF RESEARCH ON WOMEN’S HEALTH
NATIONAL INSTITUTES OF HEALTH
U.S. DEPARTMENT OF HEALTH & HUMAN SERVICES
STRATEGIC PLAN
The Honorable Barbara Mikulski, U.S. Senator, Maryland
August 16, 2010
“Fighting for women’s health has been one of my life-long priorities. For far too
long, women’s health was ignored. When I first came to the Senate, women’s
health wasn’t a national priority. Remember the famous study, take an aspirin a
day to keep the heart attack away? That study was done on 10,000 men. Not one
woman was included. In a study of the aging process, they told me women weren’t
included because there wasn’t a ladies room available for study participants. Yet the
results of these studies were being applied to men and women. I vowed to fix that.
I helped establish the Office of Research on Women’s Health at the National
Institutes of Health to make sure women were no longer being neglected. Through
this office we have been able to increase women’s inclusion in clinical drug trials
and to increase funding for breast cancer research by 700 percent since 1992. We
now know that men and women have different symptoms before a heart attack.
And there are many more biological differences that must still be studied and
understood. I will continue to fight to make sure women’s health remains a priority
in the federal checkbook and that women are not left behind when it comes to
their health and survival.”
OFFICE OF RESEARCH ON WOMEN’S HEALTH
NATIONAL INSTITUTES OF HEALTH
U.S. DEPARTMENT OF HEALTH & HUMAN SERVICES
STRATEGIC PLAN
A VISION FOR 2020 FOR WOMEN’S HEALTH RESEARCH
TABLE OF CONTENTS
3
A VISION FOR 2020 FOR WOMEN’S HEALTH RESEARCH
The Office of Research on Women’s Health addressing the health differences and needs
(ORWH) was established in September 1990 of all populations of women; and increasing
in response to congressional, scientific, and the diversity of the biomedical workforce.
advocacy concerns that a lack of systemic
and consistent inclusion of women in NIH- ACCOMPLISHMENTS
supported clinical research could result in Twenty years after the establishment of
clinical decisions being made about health ORWH, significant progress has been
care for women based solely on findings achieved in four benchmark areas: (1) policies
from studies of men—without any evidence have been developed and implemented
that they were applicable to women. The to ensure the inclusion of women in NIH
establishment of the Office heralded earnest clinical research; (2) women’s health and
efforts by NIH to develop a research agenda sex differences research has increased; (3)
addressing gaps in scientific knowledge new programs have been implemented to
about women’s health across the lifespan and prepare researchers to conduct women’s
to increase the number of scientists pursuing health research; and (4) there has been
investigations with a scientific design that new focus on interdisciplinary career
would reveal sex differences in outcomes. development and sex differences research
These aims were articulated in the first across the research continuum. Consequently,
ORWH agenda-setting report, Report of the reports on sex and gender-related factors
National Institutes of Health: Opportunities in health and disease and analysis of
for Research on Women’s Health (commonly clinical trials by sex of participants have
referred to as the Hunt Valley report). In steadily increased in the scientific literature.
1997, ORWH undertook a second systematic Over the years, the biennial reports of
program of collaborative planning and the Advisory Committee on Research on
convened a series of public hearings and Women’s Health, in collaboration with the
scientific workshops that culminated in NIH Coordinating Committee on Research
the publication of the Agenda for Research on Women’s Health, attest to the attention
on Women’s Health for the 21st Century. and greater appreciation that has developed
That agenda expanded the vision for NIH, for women’s health and sex differences
going “beyond Hunt Valley” to highlight the research in the design of studies and the
importance of promoting interdisciplinary, translation of findings into clinical practice.
collaborative research; studying and The growth of NIH-funded women’s health 5
research addressing the expanded concept of supports interdisciplinary research. In 2010,
women’s health across the lifespan—including these three ORWH-initiated programs
more than just the reproductive years while are flourishing and enjoy continuing
continuing to explore understudied areas cosponsorship from many of the NIH
of reproductive health and the menopausal institutes, centers, and offices.
transition—has been impressive. Additionally,
increasing numbers of investigator-initiated THE FUTURE
women’s health research in areas such To build on past successes and determine
as cardiovascular disease and stroke, future directions for the next generation of
musculoskeletal and immune disorders, and women’s health and sex/gender research,
mental health and substance abuse, among ORWH has once more updated the NIH
many others, reflect enormous progress. women’s health research agenda in a third
report, A Vision for 2020 for Women’s
As a result of the increased attention to Health Research: Moving Into the Future
women’s health research funded by the With New Dimensions and Strategies. The
NIH institutes and centers, women’s health report is the culmination of a 2-year strategic
scientists, providers, and advocates have planning process, involving more than
gained a strong sense of their capacity to 1,500 leading scientists, women’s health
effect change. Research on women’s health advocates, public policy experts, health care
has become a tangible reality. Furthermore, providers, Federal, State, and local elected
women’s health, sex differences, and officials, and the general public in 5 regional
interdisciplinary women’s health research scientific meetings. This Strategic Plan not
have become distinct research career only articulates new priorities, but also
paths in multiple fields, a testament to the strongly reinforces existing areas, such as
success of two ORWH signature programs: interdisciplinary and sex differences research.
Building Interdisciplinary Research Careers Unlike earlier reports, the current Plan is not
in Women’s Health (BIRCWH), established disease specific. It encompasses disease-
in 1999, and the interdisciplinary Specialized specific research in a broader vision of
Centers of Research (SCORs) on Sex women’s health that can benefit both women
and Gender Factors Affecting Women’s and men by increasing our understanding of
Health, established in 2002. As of 2010, the role of sex/gender factors in differential
the BIRCWH program has supported the disease risk, vulnerability, progression, and
career development of almost 400 early- outcome, as well as the effects of being
stage research scientists at major research female on health.
institutions throughout the United States. The
SCORs on Sex and Gender Factors Affecting Over the past 20 years, research has
Women’s Health support interdisciplinary revealed that from single cells to multiple
research, from basic to translational to biological systems and mechanisms, sex
clinical investigations, by accomplished differences exist—and these differences are
scientists; while a third program, Advancing not just hormone based. Sex differences
Novel Science in Women’s Health Research research is needed not only in fields such
6 (ANSWHR), established in 2007, further as endocrinology and immunology, but
A VISION FOR 2020 FOR WOMEN’S HEALTH RESEARCH
also in rapidly evolving science areas Moving into the Future with New Dimensions
such as epigenetics, systems biology, and and Strategies: A Vision for 2020 for
neuroscience; and new technology- Women’s Health Research reflects ORWH’s
enabled fields such as genomics, proteomics, commitment to fostering innovations
and metabolomics. in women’s health research from bench
to bedside, and from laboratories to
The health of women has a direct bearing communities. Our strategy for the NIH
on the health of their families and pledges us and our many partners to address
communities, and ultimately, the health of opportunities, challenges, and health needs
societies. In an increasingly interconnected of future generations of girls and women.
world, the health of an individual or a We continue to look to our many partners
community can, in some way, affect the among scientific groups, the public, advocacy
health of all. Women’s health research groups, and policy leaders, who played such
must encompass global considerations and a defining role in creating ORWH, to continue
continue to seek ways to address the pressing to extol women’s health research and to help
health needs of women worldwide. us realize our shared vision.
Research on
women’s health
has become a
tangible reality.
7
A VISION FOR 2020 FOR WOMEN’S HEALTH RESEARCH
I MISSION AND
HISTORICAL OVERVIEW
The Office of Research on Women’s Health 1 Advise the NIH Director and staff
(ORWH) was the first Public Health Service on matters relating to research on
office dedicated specifically to women’s women’s health.
health. The office was established at
the National Institutes of Health (NIH) 2 Strengthen and enhance research related
on September 10, 1990. The office was to diseases, disorders, and conditions that
reaffirmed by statute in congressional affect women.
legislation by the NIH Revitalization Act of
1993 to serve as the focal point for women’s 3 Ensure that research conducted and
health research at the NIH, reporting supported by NIH adequately addresses
directly to the NIH Director, and working in a issues regarding women’s health.
collaborative partnership with the institutes,
centers, and offices. Congress assigned a 4 Ensure that women are appropriately
far-reaching leadership role to the ORWH represented in biomedical and
Director by mandating that the Director be biobehavioral research studies supported
responsible for the following: by the NIH.
9
Throughout its 20-year history, ORWH has Participating in this process were more
worked in concert with the NIH institutes, than 1,500 individuals, representing the
centers, and offices and the biomedical, full spectrum of academic institutions,
behavioral, health care, and advocacy professional associations, advocacy
communities to foster understanding in organizations, health care facilities, and
support of a comprehensive approach to science policy analysts interested in research
women’s health research. During this interval, on women’s health and sex/gender factors
the office initiated two research agenda- in health and disease. Thirty-seven scientific
setting initiatives in 1991 and again in 1997. and career development working groups
Each of these efforts included public hearings were cochaired by leading external and
and scientific workshops in formulating NIH scientists, representing 44 academic
the research agenda. The first initiative institutions and 19 NIH institutes, centers, and
led to the publication of the Report of the the Office of the Director. Participants in the
National Institutes of Health: Opportunities meetings came from 33 states, Great Britain,
for Research on Women’s Health, commonly and Australia. Nearly 400 recommendations
known as the Hunt Valley report. The second emerged during the course of 5 regional
report, Agenda for Research on Women’s meetings. Public and written testimony was
Health for the 21st Century, was issued in 1998. received from 141 advocacy and academic
organizations, as well as from individuals
In October 2008, ORWH embarked on a presenting their personal health stories.
2-year process to plan the NIH women’s The concerns and issues highlighted by the
health research agenda for the next decade. public testimony brought to the forefront
The current Strategic Plan is the product of remaining gaps in knowledge and unmet
a collaborative planning process informed needs in women’s health care, and served to
by five regional scientific workshops and underscore the ultimate goal of the research
public hearings anchored in leading academic agenda, to improve the health of women.
and research institutions in St. Louis, San
Francisco, Providence, Chicago, and Atlanta. In finalizing this document, the review
Central to the approach of these meetings process involved three different levels: (1)
was a decision to seek the opinions of a a review by the Advisory Committee on
wide range of individuals from both within Research on Women’s Health; (2) a Strategic
the NIH and from external scientific and lay Plan review group consisting of external
communities regarding the research agenda scientists, some of whom also served as
for the future of women’s health. As a result, cochairs of various working groups at the
the format of each of the regional scientific regional meetings; and, finally, (3) an internal
workshops was designed to promote an NIH review. The entire process is presented in
interactive discussion involving leading three printed volumes and is also available
scientists and researchers from across the to the public on the ORWH homepage
nation, women’s health advocates, public http://orwh.od.nih.gov.
policy experts, healthcare providers and the
general public in a mutually informative and The benefit and purpose of the Strategic
10 collaborative strategic planning process. Plan are to identify a forward vision
A VISION FOR 2020 FOR WOMEN’S HEALTH RESEARCH
11
Elizabeth H. Blackburn, Ph.D.
2009 Nobel Laureate
A VISION FOR 2020 FOR WOMEN’S HEALTH RESEARCH
II VISION,
GOALS, AND OBJECTIVES
14
A VISION FOR 2020 FOR WOMEN’S HEALTH RESEARCH
15
GOAL
INCREASE SEX DIFFERENCES RESEARCH
1 IN BASIC SCIENCE STUDIES
Over the past two decades that ORWH has promoted women’s health research,
most studies of sex differences have been in clinical research. Looking forward,
and ensuring that scientific knowledge continues to advance, an expanded
conceptual framework is needed that explores variations due to sex as an integral
part of the search for knowledge across the entire research spectrum, beginning
at the most basic laboratory level. This should encompass research in diverse
fields, including genetics, immunology, endocrinology, developmental biology,
cell biology, epidemiology, microbiology, biochemistry, and toxicology, as well
as in behavioral and social sciences. Advances in these fields will be further
strengthened by emerging technologies such as high-throughput sequencing,
data acquisition, bioengineering, and bioinformatics, and on new modeling
and data analytic techniques. This convergence of information presents an
opportune time to expand what is known about the effects of biological sex on
normal development and the structure and function of cells, tissues, and organs.
Therefore, the identification of sex of origin of cells, tissues, and animal model
systems, as appropriate, can lead to improved clinical diagnosis and health care
based on accurate, sex-specific data.
OBJECTIVES
1.1 Encourage genetic and epigenetic studies to 1.6 Increase basic and translational research on sex/
identify sex differences in gene expression. gender differences in the pathobiology, prevention, and
treatment of diseases including HIV/AIDS, urinary tract
1.2 Explore sex differences in the structure and and sexually transmitted infections.
function of male and female cells (including stem cells),
tissues, organs, and physiological systems. 1.7 Investigate the actions of steroid hormones
and hormone-mimicking environmental agents on
1.3 Study sex differences using a systems biology- gene expression, cells, tissues, and organs. Apply this
based approach. This will include research based on new knowledge to sex differences in disease prevalence,
technology platforms such as microbiomics, genomics, symptoms, management and outcomes, in conditions
phenomics, proteomics, and metabolomics. such as lupus and cardiovascular diseases and to
predominantly sex-specific diseases such as breast
1.4 Include sex parameters in the design of cancer and uterine fibroids.
experiments using animal models.
1.8 Further understanding of sex/gender differences in
1.5 Promote neuroscience research to study sex/ fundamental mechanisms and patterns of behavioral and
gender differences in vulnerability to and clinical course of social functioning relevant to health and well-being.
neurological, psychiatric, and substance abuse disorders.
16 1.9 Incorporate sex/gender considerations into
discussions in scientific conferences and meetings.
A VISION FOR 2020 FOR WOMEN’S HEALTH RESEARCH
OBJECTIVES
2.1 Encourage the development of technologies that 2.6 Exploit high-resolution bioimaging technologies
will address sex-based differences at all scales of detail, to provide structural and functional imaging of sex
from the nanometer to the whole person. differences in a variety of areas such as pain, brain
activity, metabolism, infectious diseases, inflammation,
2.2 Develop novel animal, in vitro, and computational and drug delivery.
(virtual) models to study sex differences in diseases
and conditions. 2.7 Design drugs, biologics, and devices to diagnose,
prevent, and treat diseases and conditions affecting
2.3 Develop the information systems needed for women and girls.
collecting, sharing, and comparing clinical data for
diseases and conditions of women and girls. 2.8 Consider the sex and age of the patient in the
development of engineered medical products, cell-based
2.4 Develop computational models that will utilize therapeutics, and regenerative procedures.
multiple levels of analyses to address both qualitative
and quantitative outcomes of clinical research related 2.9 Encourage collaborative interactions among
to women. clinicians, bioethicists, and technologists regarding
accessibility of new technologies, drugs, and other
2.5 Work toward devising minimally invasive technolo- interventions relevant to women’s health.
gies for rapid and accurate screening, diagnosis, and 17
treatment of diseases and conditions of women and girls.
ACTUALIZE PERSONALIZED PREVENTION,
GOAL
DIAGNOSTICS, AND THERAPEUTICS
3 FOR GIRLS AND WOMEN
A major goal of biomedical research is to create knowledge that will lead to more
accurate strategies for diagnosis, and preventive and therapeutic interventions,
thereby ushering in a new era of personalized medicine. Personalized medicine
considers individual differences in genetics, morphology, behavior, and health
history. A comprehensive approach to personalized medicine must take into
account biological sex, age, and factors such as social and cultural influences.
OBJECTIVES
3.1 Conduct developmental and developmentally 3.6 Study sex/gender differences in the aging process.
�
framed research to understand the role of hormones,
hormonal changes, and reproductive transitions on cond- 3.7 Explore differences in response to therapeutic
itions affecting women and girls throughout the life span. interventions among samples of elderly women, including
OBJECTIVES
4.1 Convene futuristic thinkers from many fields of 4.4 Create solid partnerships by engaging in scientific
science, engineering, business, and the humanities to briefings and ad hoc meetings with policymakers, elected
assist in devising implementation strategies for women’s officials, and advocacy groups.
health research.
4.5 Partner with professional societies to include
4.2 Establish new ventures and initiatives with women’s health research issues in national scientific
a wide cross-section of partners, including NIH meetings and conferences, including issues involving
institutes, centers, and offices; academia; other Federal career training and development.
agencies; international organizations; private foundations;
and industry. 4.6 Expand global strategic alliances and partnerships
aimed at improving the health of women and girls
4.3 Promote an environment which uses multiple throughout the world, particularly in developing countries.
avenues and technologies to facilitate continuing input
from partners committed to improving women’s health
and promoting research.
19
DEVELOP AND IMPLEMENT NEW COMMUNICATION AND SOCIAL
GOAL
NETWORKING TECHNOLOGIES TO INCREASE UNDERSTANDING AND
5 APPRECIATION OF WOMEN’S HEALTH AND WELLNESS RESEARCH
Advances in all areas of science must be shared with diverse audiences. Effective
communication can improve health outcomes for women and girls, both for their
own sake and because women throughout the world play a central role in the
health of their families and communities. Communications, policy development,
and implementation science must be linked effectively to achieve these outcomes.
Moreover, because of cultural and racial/ethnic diversity in national and
international societies and communities, information about women’s health
research and related issues must be disseminated in culturally appropriate ways.
Multiple media strategies, along with the latest communication technologies,
should be considered in communications research to determine how to best reach
diverse audiences.
OBJECTIVES
5.1 Serve as a key informational resource for Federal 5.5 Support research to explore and evaluate the
and State agencies, elected representatives, the media, ability of women and men of different ages to access,
health and advocacy organizations, and the public on process, and act on health-related information.
women’s health research issues.
5.6 Build a central portal of information for women’s
5.2 Expand collaboration with other NIH institutes and health research findings suitable for the specific needs
centers and Federal agencies in outreach activities on of researchers, health care practitioners, patients, and
issues related to women’s health. their families.
20
A VISION FOR 2020 FOR WOMEN’S HEALTH RESEARCH
The research workforce serves as the foundation for scientific progress and must
reflect the brightest talent equipped with essential scientific knowledge and
exceptional training. Although women are well represented in early career phases
of the life sciences, there is a well-recognized underrepresentation or absence of
women in senior research leadership positions. It is therefore essential to learn
from and expand upon successful efforts and develop and implement innovative
programs and policies that will attract, retain, and advance women throughout
their scientific careers. ORWH assumes a large-scale view of these challenges and
extends career outreach efforts to include a focus on girls in secondary education
settings, particularly among underserved populations. To advance women’s health
research, it is also critical to prepare researchers with the interdisciplinary training
and knowledge to evaluate and improve all aspects of women’s health.
OBJECTIVES
6.1 Connect and empower scientists across career 6.4 Evaluate the challenges and successes of part-time
stages by developing a central career advice/ research careers and explore strategies to allow part-
development resource that includes contact with time faculty to remain involved in their fields of science.
knowledge-rich people at the NIH.
6.5 Promote recognition and understanding of
6.2 Lead the way in encouraging institutions to women’s health among future health professionals and
recognize mentoring as an essential component of scientists by informing the design of curricula with up-
building career success in their training programs; to-date research findings for use in educational materials
encourage evaluation of mentoring practices. for medical, dental, nursing, and other professional training.
21
Jeffrey Henderson, M.D., Ph.D.
Instructor of Medicine,
Washington University School of Medicine
“This program [BIRCWH] has helped me tremendously
as I begin the transition from mentored research
toward an independent research career. Through this,
I have obtained protected time to establish a research
track record and have established a helpful mentoring
relationship with several successful and established
researchers. It has also helped me to better
understand women’s health and the outstanding Valerie Flaherman, M.D., M.P.H.
questions in this area.” UCSF
“My relationship with my BIRCWH
mentors and advisors has allowed
me to move forward much more
rapidly on the path to independent
Clay Semenkovich, M.D. clinical research.”
Professor, Washington University
“….the [BIRCWH] program provides
BIRCHW—29 Programs
SCOR—11 Centers
24
A VISION FOR 2020 FOR WOMEN’S HEALTH RESEARCH
$50,000,000
$37,500,000
$25,000,000
$12,500,000
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A VISION FOR 2020 FOR WOMEN’S HEALTH RESEARCH
HOSTS: Linda C. Giudice, M.D., Ph.D., M.Sc., Robert B. Jaffe MD Endowed Professor and Chair
�
UCSF Obstetrics, Gynecology & Reproductive Sciences • Nancy Milliken, M.D., Vice Dean of the UCSF
School of Medicine & Director of the UCSF National Center of Excellence in Women’s Health
�
Estella Parrott, M.D., M.P.H. HIV/AIDS AND WOMEN Barbara A. Rapp, Ph.D.
Program Director Anissa Brown, Ph.D. Chief, Office of Planning and Analysis
Eunice Kennedy Shriver National Institute Office of AIDS Research National Library of Medicine
of Child Health and Human Development Office of the Director National Institutes of Health
National Institutes of Health National Institutes of Health Bethesda, Maryland
Bethesda, Maryland Bethesda, Maryland
WOMEN IN SCIENCE AND
Eveline Shen, M.P.H. Ruth Greenblatt, M.D. HEALTH CAREERS
Executive Director Professor of Clinical Pharmacy Elena Fuentes-Afflick, M.D., M.P.H.
Asian Communites for University of California, San Francisco Professor of Pediatrics, Epidemiology,
Reproductive Justice San Francisco, California and Biostatistics
Oakland, California San Francisco General Hospital
Susan Plaeger, Ph.D. University of California, San Francisco
Kristina Thayer, Ph.D. Director, Basic Sciences Program San Francisco, California
Staff Scientist Division of AIDS
National Institute of Environmental National Institute of Allergy and J. Taylor Harden, Ph.D.
Health Sciences, National Infectious Diseases Office of the Director
Toxicology Program National Institutes of Health National Institute on Aging
Center for the Evaluation of Risks to Bethesda, Maryland National Institutes of Health
Human Reproduction Bethesda, Maryland
National Institutes of Health Dawn K. Smith, M.D., M.S., M.P.H.
Durham, North Carolina Associate Chief for Science, Joan Y. Reede, M.D., M.P.H., M.B.A.
Epidemiology Branch Dean for Diversity and
Deborah Winn, Ph.D. Division of HIV/AIDS Prevention Community Partnership
Deputy Director Centers for Disease Control Harvard Medical School
Division of Cancer Control and and Prevention Boston, Massachusetts
Population Sciences Atlanta, Georgia
National Cancer Institute Joan P. Schwartz, Ph.D.
National Institutes of Health INFORMATION TECHNOLOGY Assistant Director
Bethesda, Maryland Irene Sue Dubman, M.A. Office of Intramural Research
Senior Director, Standards & Architecture Office of the Director
Tracey Woodruff, Ph.D., M.P.H. Genzyme National Institutes of Health
Associate Professor and Director Cambridge, Massachusetts Bethesda, Maryland
Program on Reproductive Health
and the Environment Laura J. Esserman, M.D., M.B.A.
University of California, San Francisco Director, Carol Franc Buck Breast
Oakland, California Care Center
University of California, San Francisco
San Francisco, California
29
Michelle Berlin, M.D., M.P.H. Lucia Larson, M.D. ELDERLY, FRAIL ELDERLY,
Vice Chair, OB/GYN & Director Director, Division of Obstetric and AND HEALTHY AGING
OHSU Center of Excellence in Consultative Medicine Richard Besdine, M.D.
Women’s Health Women & Infants Hospital of Professor of Medicine
Oregon Health & Science University Rhode Island Director of the Center for Gerontology
Portland, Oregon The Warren Alpert Medical School of and Health Care Research at
Brown University Brown University
Sandra A. Carson, M.D. Providence, Rhode Island Director of the Division of Geriatrics in
Medical Director of Women & Infants’ the Department of Medicine
Center for Reproduction and Infertility Donald R. Mattison, M.D. Chief of Geriatrics for Lifespan
Director of the Division of Reproductive Senior Advisor Greer Professor of Geriatric Medicine
Endocrinology and Infertility Eunice Kennedy Shriver National Institute The Warren Alpert Medical School of
Women & Infants Hospital of of Child Health and Human Development Brown University
Rhode Island National Institutes of Health Providence, Rhode Island
The Warren Alpert Medical School of Bethesda, Maryland
Brown University Stefan Gravenstein, M.D., M.P.H., CMD,
Providence, Rhode Island Errol R. Norwitz, M.D., Ph.D. FACP, AGSF
Professor Clinical Director, Quality Partners
REPRODUCTIVE AND Yale University School of Medicine of Rhode Island
MIDDLE YEARS New Haven, Connecticut Division of Geriatrics, Department
Robert Barbieri, M.D. of Medicine
Chairperson, Obstetrics and Gynecology Katharine Wenstrom, M.D. The Warren Alpert Medical School
Brigham and Women’s Hospital Director, Maternal-Fetal Medicine Division of Brown University
Harvard Medical School Women & Infants Hospital of Providence, Rhode Island
Boston, Massachusetts Rhode Island
Providence, Rhode Island Stacy Tessler Lindau, M.D., M.A.P.P.
Alan DeCherney, M.D. Assistant Professor
Program Head MENOPAUSAL TRANSITION University of Chicago
Eunice Kennedy Shriver National Institute Paul A. DiSilvestro, M.D. Chicago, Illinois
of Child Health and Human Development Principal Investigator for Gynecologic
National Institutes of Health Oncology Group Susan M. Resnick, Ph.D.
Bethesda, Maryland The Warren Alpert Medical School of Senior Investigator
Brown University National Institute on Aging
Valerie C. Montgomery Rice, M.D. Women & Infants Hospital National Institutes of Health
Executive Director, CWHR Providence, Rhode Island Baltimore, Maryland
Meharry Medical College
Nashville, Tennessee Andrew A. Monjan, Ph.D., M.P.H. Bernadette Tyree, Ph.D.
Scientist Consultant Health Scientist Administrator
Cynthia Casson Morton, Ph.D. National Institute on Aging National Institute of Arthritis and
Professor National Institutes of Health Musculoskeletal and Skin Diseases
Brigham and Women’s Hospital Columbia, Maryland National Institutes of Health
Harvard Medical School Bethesda, Maryland
Boston, Massachusetts Robert W. Rebar, M.D.
Executive Director ORAL HEALTH AND
PREGNANCY American Society for SYSTEMIC CONDITIONS
Alicia Y. Armstrong, M.D., MHSCR Reproductive Medicine Jane C. Atkinson, D.D.S.
Associate Fellowship Director, Birmingham, Alabama Director, Center for Clinical Research
Reproductive Endocrinology Fellowship National Institute of Dental and
Eunice Kennedy Shriver National Institute Jacques E. Rossouw, M.D. Craniofacial Research
of Child Health and Human Development Branch Chief National Institutes of Health
National Institutes of Health Women’s Health Initiative Bethesda, Maryland
Walter Reed Army Medical Center National Heart, Lung, and Blood Institute
Bethesda, Maryland National Institutes of Health Raul Garcia, D.M.D., M.M.Sc.
Bethesda, Maryland Professor and Chair
Henry M. Goldman School of
Marcia L. Stefanick, Ph.D. Dental Medicine
Professor of Medicine and Professor Boston University
of OB/GYN Boston, Massachusetts
Stanford Prevention Research Center
30 Stanford University
Stanford, California
A VISION FOR 2020 FOR WOMEN’S HEALTH RESEARCH
32
A VISION FOR 2020 FOR WOMEN’S HEALTH RESEARCH
Vivian W. Pinn, M.D., Chairperson Scott J. Hultgren, Ph.D. Claire Pomeroy, M.D., M.B.A.
Associate Director for Research on Helen L. Stoever Professor of Vice Chancellor, Human Health Sciences
Women’s Health Molecular Microbiology Dean, School of Medicine
Director, Office of Research on Director of the Center for Women’s Professor of Internal Medicine and
Women’s Health Infectious Disease Research Microbiology/Immunology
National Institutes of Health Department of Molecular Microbiology University of California, Davis
Washington University School of
Joyce Rudick, Executive Secretary Medicine Sally Rosen, M.D., M.F.S.
Director, Programs and Management Founding Director, Center for Women’s
Office of Research on Women’s Health Paula A. Johnson, M.D., M.P.H. Health Research, Leadership
National Institutes of Health Executive Director, Connors Center for and Advocacy
Women’s Health and Gender Biology Temple University
Francisco Garcia, M.D., M.P.H. Chief, Division of Women’s Health
Distinguished Outreach Professor Brigham and Women’s Hospital Jeanne Craig Sinkford, D.D.S., Ph.D.
of Obstetrics and Gynecology and Professor and Dean Emeritus
Public Health Karen Kim, M.D., M.S. Howard University College of Dentistry
Director, Center of Excellence in Associate Professor of Medicine Associate Executive Director and Director,
Women’s Health The University of Chicago Center for Equity and Diversity
The University of Arizona American Dental Education Association
Nancy H. Nielsen, M.D., Ph.D.
Margery L.S. Gass, M.D. Immediate Past President, American Susan P. Sloan, M.D.
Executive Director Medical Association Program Director, Internal Medicine
North American Menopause Senior Associate Dean Drexel University College of Medicine
Society (NAMS) SUNY at Buffalo School of Medicine and
Biomedical Sciences Farida Sohrabji, Ph.D.
Ronald S. Gibbs, M.D. Office of Medical Education Associate Professor and Associate
Professor, Department of SUNY at Buffalo Department Head
Obstetrics & Gynecology Department of Neuroscience and
Associate Dean, Continuing Nancy Norton Experimental Therapeutics
Medical Education Founder and President, International Texas A&M System Health Science Center
University of Colorado Denver Foundation for Functional College of Medicine
School of Medicine Gastrointestinal Disorders
Chairperson, Digestive Disease Gary E. Striker, M.D.
Linda C. Giudice, M.D., Ph.D. National Coalition Professor
The Robert B. Jaffe, M.D., Endowed University of Miami School of Medicine
Professor and Chair Mary Beth O’Connell, Pharm.D.,
Department of Obstetrics, Gynecology BCPS, FASHP, FCCP Paul F. Terranova, Ph.D.
and Reproductive Sciences Associate Professor, Wayne Vice Chancellor for Research
University of California, San Francisco State University Senior Associate Dean for Research
Eugene Applebaum College of & Graduate Education
Ronda S. Henry-Tillman, M.D. Pharmacy & Health Sciences The University of Kansas Medical Center
Practice Director, Ladies’ Oncology Clinic School of Medicine
Director, Cancer Control Mary I. O’Connor, M.D.
Winthrop P. Rockefeller Cancer Institute Chair, Department of Orthopedic Surgery Debra Toney, Ph.D., RN
University of Arkansas for Department of Orthopedics, Mayo Clinic President, TLC Health Care Service
Medical Sciences President, National Black Nurses
Eugene P. Orringer, M.D. Association
Constance A. Howes, J.D. Executive Associate Dean for Faculty
President and Chief Executive Officer Affairs and Faculty Development Barbara Yee, Ph.D.
Women & Infants Hospital of School of Medicine Professor and Chair
Rhode Island University of North Carolina, Chapel Hill Department of Family and
Consumer Sciences
University of Hawaii at Manoa
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A VISION FOR 2020 FOR WOMEN’S HEALTH RESEARCH
Francisco Garcia, M.D., M.P.H. Paula A. Johnson, M.D., M.P.H. Valerie C. Montgomery Rice, M.D.
Distinguished Outreach Professor Executive Director, Connors Center for
Senior Vice President for Health Affairs
of Obstetrics and Gynecology and Women’s Health and Gender Biology Dean, School of Medicine
Public Health Chief, Division of Women’s Health Meharry Medical College
Director, Center of Excellence in Brigham and Women’s Hospital
Women’s Health Nancy H. Nielsen, M.D., Ph.D.
The University of Arizona Linda M. Kaste, D.D.S., Ph.D., M.S. Senior Associate Dean, SUNY at Buffalo
Associate Professor School of Medicine and
Jill M. Goldstein, Ph.D. University of Illinois at Chicago, Biomedical Sciences
Director of Research, Connors Center for College of Dentistry Office of Medical Education
Women’s Health and Gender Biology SUNY at Buffalo
Division of Women’s Health Phoebe S. Leboy, Ph.D.
Brigham and Women’s Hospital President, Association for
Judith G. Regensteiner, Ph.D.
Women in Science Professor of Medicine
Scott J. Hultgren, Ph.D. Professor General Internal Medicine/Cardiology
Helen L. Stoever Professor of University of Pennsylvania University of Colorado-Denver School
Molecular Microbiology of Medicine
Director of the Center for Women’s Jon E. Levine, Ph.D.
Infectious Disease Research Professor, Neurobiology and Physiology Janet W. Rich-Edwards, M.P.H., Sc.D.
Department of Molecular Microbiology Northwestern University Director of Developmental Epidemiology
Washington University School Division of Women’s Health/
of Medicine Department of Medicine
Brigham and Women’s Hospital
35
APPENDIX D: COORDINATING COMMITTEE
ON RESEARCH ON WOMEN’S HEALTH
NATIONAL INSTITUTES OF HEALTH • 2010
Margaret V. Ames, Ph.D Gale A. Dutcher, M.L.S., M.S. Barbara R. Marzetta, M.S.
Acting Director Head Deputy Director
Office of Science Planning Office of Outreach and Office of Science and Technology
and Assessment Special Populations National Heart, Lung, and Blood Institute
National Cancer Institute National Library of Medicine
Kate Nagy, M.A.
Jane C. Atkinson, D.D.S. Paula Flicker, Ph.D. Program Analyst
Director, Center for Clinical Research Program Director National Institute on Aging
National Institute of Dental and National Institute of General
Craniofacial Research Medical Sciences Lisa A. Neuhold, Ph.D.
Program Director for Retinal Diseases
Sanja Basaric Eleanor F. Hoff, Ph.D. National Eye Institute
Program Analyst Health Science Policy Analyst
National Human Genome Office of Scientific Program and Sheila A. Newton, Ph.D., M.S.
Research Institute Policy Analysis Director
National Institute of Diabetes and Office of Policy, Planning, and Evaluation
Gina M. Brown, M.D. Digestive and Kidney Diseases National Institute of Environmental
Director, Women and Girls Section Health Sciences
Office of AIDS Research Tanya Hoodbhoy, Ph.D.
Office of the Director Program Director Wendy J. Nilsen, Ph.D.
Office of Strategic Coordination Health Scientist Administration
John T. Burklow Division of Program Coordination, Office of Behavioral and Social Sciences
Director, Office of Communications Planning, and Strategic Initiatives Research
Office of the Director Office of the Director Office of the Director
36
A VISION FOR 2020 FOR WOMEN’S HEALTH RESEARCH
37
Jacques Rossouw, M.D. Elaine Sierra-Rivera, Ph.D. Susanne S. Strickland, M.S.
Project Officer, Women’s Health Initiative Scientific Review Administrator/ Chief, Strategic Coordination Branch and
National Heart, Lung, and Blood Institute Deputy Chief Women’s Health Center
Oncology Sciences Integrated National Cancer Institute
Milagros Ruiz Review Group
Program Analyst/Contractor Center for Scientific Review Stacy Wallick
John E. Fogarty International Center Public Health Analyst
Lana R. Skirboll, Ph.D. National Institute of Biomedical Imaging
Joan P. Schwartz, Ph.D. Acting Director and Bioengineering
Assistant Director Division of Program Coordination,
Office of Intramural Research Planning, and Strategic Initiatives
38
A VISION FOR 2020 FOR WOMEN’S HEALTH RESEARCH
Janine Austin Clayton, M.D., Deputy Director Indira P. Jevaji, M.D., Medical Officer
Lisa Begg, Dr. P.H., R.N., Director, Research Programs Teresa R. Kendrix, Administrative Officer
Joyce E. Rudick, Director, Programs & Management Joslyn Yudenfreund Kravitz, Ph.D., Program Analyst
Angela C. Bates, M.B.A., Program Analyst Kimberly S. Kurilla-Gray, Secretary to the Director
Nida H. Corry, Ph.D., AAAS Science & Technology Policy Fellow Dennis F. Mangan, Ph.D., Health Scientist Administrator
Eleanor Z. Hanna, Ph.D., Associate Director, Charles A. Wells, Ph.D., Senior Advisor to the Director
Special Projects and Centers
ACKNOWLEDGEMENTS
The Office of Research on Women’s Health wishes to acknowledge the contributions of the working group co-chairs,
the many scientists, advocacy representatives and members of the public who participated in the five regional scientific
meetings. A note of thanks also goes to the graduate and post-graduate students, and fellows at the various academic
institutions who volunteered to assist the working group co-chairs in capturing the discussions of the individual working
groups. A special thanks to Mary Blehar, Ph.D. and Barbara Lynch, Ph.D. for their work as the overall science writers for
this effort, with a further acknowledgement to Dr. Blehar for her assistance to ORWH staff in developing this volume.
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NIH Publication No. 10-7606