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Helmut Sies
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PII: S2213-2317(15)00003-8
DOI: http://dx.doi.org/10.1016/j.redox.2015.01.002
Reference: REDOX247
To appear in: Redox Biology
Received date: 28 December 2014
Accepted date: 1 January 2015
Cite this article as: Helmut Sies, Oxidative stress: a concept in redox biology and
medicine, Redox Biology, http://dx.doi.org/10.1016/j.redox.2015.01.002
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Commentary
Keywords
Oxidative stress, redox balance, oxidants, antioxidants, redox signaling, adaptive response
Highlights
Outlook
Current interest into the linkage of oxidative stress to inflammation and inflammatory
responses is adding a new perspective. For example, inflammatory macrophages release
glutathionylated peroxiredoxin-2, which then acts as a ‗danger signal‘ to trigger the
production of tumor necrosis factor-alpha (29). The orchestrated responses to danger signals
related to damage-associated molecular patterns (DAMPs) include relations to oxidative stress
(30). Under oxidative stress conditions, a protein targeting factor, Get3 in yeast (mammalian
TRC40) functions as an ATP-independent chaperone (31). More detailed molecular
understanding will also deepen the translational impact into biology and medicine; as
mentioned above, these aspects are beyond this Commentary and will be treated elsewhere.
However, it might be mentioned, for example, that viral and bacterial infections are often
associated with deficiencies in micronutrients, including the essential trace element, selenium,
the redox-active moiety in selenoproteins. Selenium status may affect the function of cells in
both adaptive and innate immunity (32). Major diseases, now even diabetes Type 2, are being
considered as ‗redox disease‘ (33).
Molecular insight will enhance the thrust of the concept of oxidative stress, which is
intimately linked to cellular energy balance. Thus, the subcellular compartmentation of redox
processes and redox components is being studied at a new level, in mammalian cells (34) as
well as in phototrophic organisms (35). New insight from spatiotemporal organisation of
hydrogen peroxide metabolism (36) complements the longstanding interest in hydroperoxide
metabolism in mammalian organs and its relationship to bioenergetics (37).
The following quote attributed to Hans Selye [38] might well apply to the concept of
oxidative stress: ― If only stress could be seen, isolated and measured, I am sure we could
enormously lengthen the average human life span‖.
Acknowledgements.
I gratefully acknowledge the input and friendship of many colleagues in shaping ideas in this
multidisciplinary field; of many close associates, Enrique Cadenas and Wilhelm Stahl in
particular, and close colleagues Dean Jones, Bruce Ames, Lester Packer, Alberto Boveris.
Also to Masayasu Inoue for the translation of the book ‗Oxidative Stress‘ into Japanese. Last,
but not least, to the many active scientists in this research field, gathered under the umbrella
of the Society for Free Radical Research International (SFRRI) and related organisations such
as the Oxygen Club of California (OCC).
I also am thankful for the research support by the National Foundation of Cancer
Research (NFCR), Bethesda, MD, USA, and the Deutsche Forschungsgemeinschaft and the
Alexander-von-Humboldt Foundation.
References
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Graphical Abstract
Table 1.
Photooxidative stress
Ultraviolet (UV-A, UV-B)
Infrared-A
Nitrosative stress
Reductive stress