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15. Steeds, Charlotte E. Anatomy and Physiology of Pain. Surgery [Internet].
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23. Hartono Ruddi, Wiwi Jaya, Djudjuk Rahmad Basuki. Pengaruh Pemberian
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19630495

62
 LAMPIRAN

Lampiran 1. Informed consent

JUDUL PENELITIAN : Pengaruh Pemberian Parasetamol 1000 MG
Intravena Perioperatif Terhadap Penggunaan
Fentanyl pada Pasien Kraniotomi di RSUP Dr.
Kariadi Semarang

INSTANSI PELAKSANA : Fakultas Kedokteran Universitas Diponegoro

PENELITI : Irma Amalia

Persetujuan Setelah Penjelasan

(INFORMED CONSENT)

Berikut ini naskah yang akan dibacakan pada Responden / Ibu Responden
Penelitian :
(a.I. berisi penjelasan apa yang akan dialami oleh responden diwawancarai)
Yth Bapak/Ibu :
Peneliti yang tersebut diatas adalah Mahasiswa Fakultas Kedokteran Universitas
Diponegoro yang bermaksud ingin menggunakan data rekam medik dalam
peneitian ini dengan tujuan mengetahui pengaruh pemberianm parasetamol 1000
mg intravena perioperatif terhadap penggunaan fentanyl pada pasien kraniotomi
di RSUP Dr. Kariadi Semarang. Peneliti akan mengambil data identitas,
kebutuhan fentanyl yang diperlukan selama operasi, skor visual analog scale,
serta kejadian mual muntah yang terjadi pada pasien tersebut. Peneliti menjamin
kerahasiaan identitas dan informasi yang diberikan. Informasi tersebut hanya
digunakan untuk kepentingan penelitian. Bapak/ Ibu berhak menolak dan
keluardari penelitian sesuai dengan keinginan.
Terima kasih atas kerjasama Bapak/Ibu/Sdr.

63
Setelah mendengar dan memahami penjelasan penelitian, dengan ini saya
menyatakan

SETUJU / TIDAK SETUJU

Untuk ikut sebagai responden / sampel penelitian.

Semarang,………………..... 2014

Saksi : Nama Terang :

Nama Terang : Alamat :
Alamat :

64
Lampiran 2. Ethical clearance

65
Lampiran 3. Surat ijin penelitian

66
Lampiran 4. Laporan Tindakan Anestesi

67
68
Lampiran 6. Lembar Evaluasi

69
70
Lampiran 6. Data SPSS
Crosstabs

Jenis kelamin * Kelompok Crosstabulation

Kelompok
Kontrol Perlakuan Total
Jenis kelamin Laki-laki Count 7 6 13
Expected Count 6.5 6.5 13.0
% within Kelompok 35.0% 30.0% 32.5%
% of Total 17.5% 15.0% 32.5%
Perempuan Count 13 14 27
Expected Count 13.5 13.5 27.0
% within Kelompok 65.0% 70.0% 67.5%
% of Total 32.5% 35.0% 67.5%
Total Count 20 20 40
Expected Count 20.0 20.0 40.0
% within Kelompok 100.0% 100.0% 100.0%
% of Total 50.0% 50.0% 100.0%

Chi-Square Tests

Asymp. Sig. Exact Sig. Exact Sig.

Value df (2-sided) (2-sided) (1-sided)
Pearson Chi-Square .114b 1 .736
Continuity Correction a .000 1 1.000
Likelihood Ratio .114 1 .736
Fisher's Exact Test 1.000 .500
Linear-by-Linear
.111 1 .739
Association
N of Valid Cases 40
a. Computed only for a 2x2 table
b. 0 cells (.0%) have expected count less than 5. The minimum expected count is 6.
50.

71
Umur

Case Summaries

Umur
Kelompok N Mean Std. Deviation Median Minimum Maximum
Kontrol 20 38.90 12.208 35.00 18 57
Perlakuan 20 43.20 12.792 44.50 15 72
Total 40 41.05 12.533 41.00 15 72

Tests of Normality
a
Kolmogorov-Smirnov Shapiro-Wilk
Kelompok Statistic df Sig. Statistic df Sig.
Umur Kontrol .156 20 .200* .924 20 .120
Perlakuan .113 20 .200* .980 20 .931
*. This is a lower bound of the true significance.
a. Lilliefors Significance Correction

80

25

60
Umur

40

20
35

Kontrol Perlakuan
Kelompok

72
T-Test

Group Statistics

Std. Error
Kelompok N Mean Std. Deviation Mean
Umur Kontrol 20 38.90 12.208 2.730
Perlakuan 20 43.20 12.792 2.860

Independent Samples Test

Umur
Equal variances Equal variances
assumed not assumed
Levene's Test for F .227
Equality of Variances Sig. .636
t-test for Equality of t -1.088 -1.088
Means df 38 37.917
Sig. (2-tailed) .284 .284
Mean Difference
-4.300 -4.300

Std. Error Difference

3.954 3.954

95% Confidence Interval Lower -12.304 -12.305

of the Difference Upper 3.704 3.705

73
Lama operasi

Case Summaries

Lama operasi
Kelompok N Mean Std. Deviation Median Minimum Maximum
Kontrol 20 279.00 75.457 285.00 150 420
Perlakuan 20 300.00 97.939 300.00 165 480
Total 40 289.50 86.948 300.00 150 480

Tests of Normality
a
Kolmogorov-Smirnov Shapiro-Wilk
Kelompok Statistic df Sig. Statistic df Sig.
Lama operasi Kontrol .158 20 .200* .940 20 .236
Perlakuan .180 20 .089 .919 20 .095
*. This is a lower bound of the true significance.
a. Lilliefors Significance Correction

500

400
Lama operasi

300

200

100

Kontrol Perlakuan
Kelompok

74
T-Test

Group Statistics

Std. Error
Kelompok N Mean Std. Deviation Mean
Lama operasi Kontrol 20 279.00 75.457 16.873
Perlakuan 20 300.00 97.939 21.900

Independent Samples Test

Lama operasi
Equal variances Equal variances
assumed not assumed
Levene's Test for F 2.396
Equality of Variances Sig. .130
t-test for Equality of t -.760 -.760
Means df 38 35.679
Sig. (2-tailed) .452 .452
Mean Difference
-21.000 -21.000

Std. Error Difference

27.646 27.646

95% Confidence Interval Lower -76.966 -77.086

of the Difference Upper 34.966 35.086

75
Kelompok

Case Summaries

Kelompok VAS.1 VAS.24

Kontrol N 20 20
Mean 2.50 1.90
Std. Deviation 1.051 .553
Median 2.00 2.00
Minimum 1 1
Maximum 4 3
Perlakuan N 20 20
Mean 1.25 1.00
Std. Deviation 1.372 .973
Median 1.00 1.00
Minimum 0 0
Maximum 4 3
Total N 40 40
Mean 1.88 1.45
Std. Deviation 1.362 .904
Median 2.00 2.00
Minimum 0 0
Maximum 4 3

Tests of Normality
a
Kolmogorov-Smirnov Shapiro-Wilk
Kelompok Statistic df Sig. Statistic df Sig.
VAS.1 Kontrol .283 20 .000 .845 20 .004
Perlakuan .269 20 .001 .815 20 .001
VAS.24 Kontrol .372 20 .000 .728 20 .000
Perlakuan .250 20 .002 .839 20 .003
a. Lilliefors Significance Correction

76
VAS.1

3
VAS.1

Kontrol Perlakuan
Kelompok

VAS.24

16
3
11

2.5

2
VAS.24

1.5

1 4
1
3 10

0.5

Kontrol Perlakuan
Kelompok

77
Kontrol

NPar Tests

Wilcoxon Signed Ranks Test

Ranks

N Mean Rank Sum of Ranks

VAS.24 - VAS.1 Negative Ranks 9a 6.94 62.50
Positive Ranks 3b 5.17 15.50
Ties 8c
Total 20
a. VAS.24 < VAS.1
b. VAS.24 > VAS.1
c. VAS.24 = VAS.1

Test Statisticsb

VAS.24 -
VAS.1
Z -1.877a
Asymp. Sig. (2-tailed) .061
a. Based on positive ranks.
b. Wilcoxon Signed Ranks Test

78
Perlakuan

NPar Tests

Wilcoxon Signed Ranks Test

Ranks

N Mean Rank Sum of Ranks

VAS.24 - VAS.1 Negative Ranks 6a 6.17 37.00
Positive Ranks 4b 4.50 18.00
Ties 10c
Total 20
a. VAS.24 < VAS.1
b. VAS.24 > VAS.1
c. VAS.24 = VAS.1

Test Statisticsb

VAS.24 -
VAS.1
Z -1.026a
Asymp. Sig. (2-tailed) .305
a. Based on positive ranks.
b. Wilcoxon Signed Ranks Test

79
NPar Tests

Mann-Whitney Test

Ranks

Kelompok N Mean Rank Sum of Ranks

VAS.1 Kontrol 20 25.68 513.50
Perlakuan 20 15.33 306.50
Total 40
VAS.24 Kontrol 20 26.15 523.00
Perlakuan 20 14.85 297.00
Total 40

Test Statisticsb

VAS.1 VAS.24
Mann-W hitney U 96.500 87.000
Wilcoxon W 306.500 297.000
Z -2.906 -3.239
Asymp. Sig. (2-tailed) .004 .001
Exact Sig. [2*(1-tailed a a
.004 .002
Sig.)]
a. Not corrected for ties.
b. Grouping Variable: Kelompok

80
Kelompok

Case Summaries

Delta VAS
Kelompok N Mean Std. Deviation Median Minimum Maximum
Kontrol 20 -.60 1.314 .00 -3 2
Perlakuan 20 -.25 1.020 .00 -3 1
Total 40 -.43 1.174 .00 -3 2

Tests of Normality
a
Kolmogorov-Smirnov Shapiro-Wilk
Kelompok Statistic df Sig. Statistic df Sig.
Delta VAS Kontrol .226 20 .009 .930 20 .155
Perlakuan .297 20 .000 .847 20 .005
a. Lilliefors Significance Correction

Delta VAS

0
Delta VAS

-1

-2

27
-3

Kontrol Perlakuan
Kelompok

81
NPar Tests

Mann-Whitney Test

Ranks

Kelompok N Mean Rank Sum of Ranks

Delta VAS Kontrol 20 18.78 375.50
Perlakuan 20 22.23 444.50
Total 40

Test Statisticsb

Delta VAS
Mann-Whitney U 165.500
Wilcoxon W 375.500
Z -.986
Asymp. Sig. (2-tailed) .324
Exact Sig. [2*(1-tailed a
.355
Sig.)]
a. Not corrected for ties.
b. Grouping Variable: Kelompok

Fentanyl

Case Summaries

Fentanyl
Kelompok N Mean Std. Deviation Median Minimum Maximum
Kontrol 20 201.25 67.119 200.00 100 350
Perlakuan 20 185.00 96.108 175.00 100 400
Total 40 193.13 82.234 200.00 100 400

Tests of Normality
a
Kolmogorov-Smirnov Shapiro-Wilk
Kelompok Statistic df Sig. Statistic df Sig.
Fentanyl Kontrol .207 20 .024 .926 20 .129
Perlakuan .212 20 .019 .821 20 .002
a. Lilliefors Significance Correction

82
 400

350

300
Fentanyl

250

200

150

100

Kontrol Perlakuan
Kelompok

83
NPar Tests

Mann-Whitney Test

Ranks

Kelompok N Mean Rank Sum of Ranks

Fentanyl Kontrol 20 22.45 449.00
Perlakuan 20 18.55 371.00
Total 40

Test Statisticsb

Fentanyl
Mann-Whitney U 161.000
Wilcoxon W 371.000
Z -1.087
Asymp. Sig. (2-tailed) .277
Exact Sig. [2*(1-tailed a
.301
Sig.)]
a. Not corrected for ties.
b. Grouping Variable: Kelompok

84
Mual muntah

Case Summaries

Mual muntah
Kelompok N Mean Std. Deviation Median Minimum Maximum
Kontrol 20 .30 .657 .00 0 2
Perlakuan 20 .00 .000 .00 0 0
Total 40 .15 .483 .00 0 2

Tests of Normalityb
a
Kolmogorov-Smirnov Shapiro-Wilk
Kelompok Statistic df Sig. Statistic df Sig.
Mual muntah Kontrol .476 20 .000 .515 20 .000
a. Lilliefors Significance Correction
b. Mual muntah is constant when Kelompok = Perlakuan. It has been omitted.

2
2
16

1.5
Mual muntah

76
1

0.5

Kontrol Perlakuan
Kelompok

85
NPar Tests

Mann-Whitney Test

Ranks

Kelompok N Mean Rank Sum of Ranks

Mual muntah Kontrol 20 22.50 450.00
Perlakuan 20 18.50 370.00
Total 40

Test Statisticsb

Mual muntah
Mann-Whitney U 160.000
Wilcoxon W 370.000
Z -2.079
Asymp. Sig. (2-tailed) .038
Exact Sig. [2*(1-tailed a
.289
Sig.)]
a. Not corrected for ties.
b. Grouping Variable: Kelompok

86
Lampiran 7. Dokumentasi

87
Lampiran 8. Biodata mahasiswa

BIODATA MAHASISWA

Nama : Irma Amalia

NIM : 22010110120005
Tempat/tanggal lahir : Jakarta 14 Januari 1993
Jenis Kelamin : Perempuan
Alamat : Jl. Cipinang Jaya GG No. 12 C Jakarta
Nomor Telepon : 082133353592
e-mail : irmamalia@gmail.com

Riwayat Pendidikan Formal

1. SD : SD BPS&K III Lulus tahun: 2004
2. SMP : SMP N 52 Jakarta Lulus tahun: 2007
3. SMA : SMA N 54 Jakarta Lulus tahun: 2010
4. FK UNDIP : Masuk tahun: 2010

88