Abstracts e227
were either systolic or diastolic blood pressure increased .46 cases have hyperten-
sion only in the night. The night time systolic blood pressure of CKD patients
were also corresponding increased by the increased of CKD stage, but only the
CKD3–5 phase group and CKD1 group, there were significant differences, P <
0.05, The night time diastolic blood pressure were no significant differences in
three groups. The incidence of nocturnal hypertension in three groups were also
corresponding increased by the increased of CKD stage, It was 31.1%, 35.6%,
36.4%, respectively.
Conclusion: The incidence of nocturnal hypertension was higher in CKD pa-
tients who was with normal blood pressure, The ABPM should be performed in
CKD patients, In order to find the nocturnal hypertension and other abnormal
Keywords: “chronic kidney disease’’,“ clinic blood pressure’’,“ ambulatory
blood Pressure’’, nocturnal hypertension
A14253 ANTI HYPERTENSIVE EFFECT OF GARCINIA
MANGOSTANA LINN EXTRACT IN HIGH RISK
FRAMINGHAM SCORE’S PATIENT
Muhamad Rizki Fadlan, Muhamad Rizki Fadlan, Djanggan Sargowo,
Ardian Rizal. Cardiology And Vascular Medicine Brawijaya University Indonesia
Objectives: this study was to examine the antihypertensive effects of Garcinia
mangostana Linn extract consumption in humans
Methods: A randomized, Single-blind, placebo-controlled clinical trial was con-
ducted in 66 pre- and mildly hypertensive adults which were determined based on
JNC VII, age 50–70 y, Patients use combination of antihypertension drug were
excluded. The patients were divided into two group. One group given 2520 mg/
day Garcinia mangostana Linn extracts in 3 divided dose for 90 days and the other
group given placebo. A standardized method was used to measure BP at baseline
and monthly intervals. The parameters were Nitrit Oxide (NO), IL-1,IL-6, mea-
sured at baseline and after 90 day’s of treatment
Results: At 90 days, Garcinia mangostana Linn extracts lowered systolic BP
(SBP) compared with placebo (−22.82 ± 11.4 vs. − 10 ± 16.0 mmHg; P = 0.007).
Diastolic BP was also lower, although this change did not differ from placebo
(−8.7 ± 11.2 vs. − 5,4 ± 9.3 mmHg; P = 0.21). The change in heart rate was signifi-
cance compared with placebo (−6.13 ± 9,6/min vs. 1,43 ± 3.04/min; P = 0.021).
The change in mean arterial pressure was significance compared with placebo
(−13,47 ± 12,01 vs. − 7,03 ± 9.7 mmHg; P = 0.028). Interestingly, we found that
there was a significance decreasing in Nitric Oxide (NO) compared with placebo
(−8.23 ± 14,9 uM vs. 4,3 ± 14.51 uM; P = 0.002). We found that The plasma IL-6
and IL-1 concentration was significantly lower compared with placebo (−95.86 ±
107,3 pg/ml vs. 37,87 ± 149,89 pg/ml; P = 0.000; − 11.26 ± 16,46 pg/ml vs. 9.59
± 13.65 pg/ml; P = 0.000, respetively).
Conclusion: These results suggest that consumption of Garcinia mangostana
Linn extract significantly reduce systolic blood pressure in pre- and mildly hy-
pertensive adults
Keywords: Garcinia Mangostana, Hypertension, Blood Pressure
A14304 EFFECT OF SEASONS ON PATIENTS WITH WHITE COAT
HYPERTENSION IN SOUTH CHINA
Huang xiaozhong1, Chen Zhujun2, Chen Luyuan2. 1Cardiaology Guangdong
General hospital China, People’s Republic of, 2Cardiology Guangdong General
Hospital China, People’s Republic of
Objectives: To evaluate the effect of summer and winter on patients with white
coat hypertension in south china.
Methods: 51 Patients with normal home blood pressure and elevated office blood
pressure measured for three times in summer and winter, the effect of seasons on
patients with white coat hypertension were evaluated.
Results: Patients with white coat hypertension showed increased office blood
pressure(43 vs 27) and decreased office normal blood pressure(8 vs 24) in sum-
mer compared with those in winter, elevated three times (152.27 ± 17.70mmHg
vs 148.21 ± 13.57mmHg, 152.00 ± 17.39mmHg vs 141.64 ± 15.74mmHg,
144.94 ± 18.96mmHg vs 136.67 ± 16.17mmHg) and average office systolic
blood pressure(150.12 ± 12.77mmHg vs 142.96 ± 12.74mmHg), First and second
times(77.18 ± 12.14mmHg vs 74.98 ± 11.10, 75.59 ± 11.58mmHg vs 74.18 ±
10.91mmHg) and average office diastolic blood pressure(75.63 ± 10.60mmHg vs
74.46 ± 10.25mmHg) in summer compared with those in winter.
Conclusion: Patients with white coat hypertension showed elevated office systol-
ic and diastolic blood pressure in summer compared with those in winter, maybe
related to increased stress response caused by high temperature in summer and
reduced stress response in comfortable temperature in winter in south china.
Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.
Keywords: summer; winter; white coat hypertension; office blood pressure;
home blood pressure
A14343 WHOLE-EXOME SEQUENCING IDENTIFIES A CODING
VARIANT IN SULT1A2 GENE ASSOCIATED WITH
OBESITY IN CHINESE CHILDREN
Meixian Zhang1, Wenke Li2, Xiaoyuan Zhao1, Liwang Gao1, Lijun Wu1, Hong
Cheng1, Dongqing Hou1, Junting Liu1, Jianxin Wu1, Zhou Zhou2, Jie MI1. 1De-
partment of Epidemiology Capital Institute of Pediatrics China, People’s Repub-
lic of, 2State Key Laboratory of Cardiovascular Disease Fuwai Hospital, National
Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and
Peking Union Medical College China, People’s Republic of
Objectives: Despite numerous genetic variants associated with obesity-related traits
have been identified, much of the obesity heritability remains unexplained. We aimed
to identify novel coding variants and genes associated with childhood obesity in China.
Methods: The study comprised three stages. We conducted deep-depth (50 × )
whole exome sequencing in 18 severely obese and 15 lean children. After several
filtering steps, we retained promising single nucleotide variants (SNVs) nominal
association (P ≤ 0.05) with obesity, dyslipidemia or impaired plasma glucose for
validation in 2,403 obese and 3,778 non-overweight children. Variants showing
potential associations were confirmed by Sanger sequencing.
Results: Exome sequencing identified 43,264 functional SNVs. We identified
two coding variants were associated with common or central obesity at exome-
wide significance: rs1059491 in the SULT1A2 gene for common obesity (P =
2.18 × 10–24, odds ratio = 2.16) and rs768847893 in the MXRA5 gene for central
obesity (P = 2.57 × 10–8, odds ratio = 2.96, females only).
Conclusion: Our findings demonstrate that rs1059491 is strongly associated
with common obesity in Chinese children. Additionally, rs768847893 is associ-
ated with central obesity in female. Our results provide evidence of the existence
of coding variants associated with obesity and have important implications for the
pathophysiology of obesity.
Keywords: whole exome sequencing, obesity, single nucleotide polymorphism
(SNP), children and adolescents
A14345 A NESTED CASE-CONTROL STUDY ON PLASMA
VITAMIN E AND RISK OF CANCER: EVIDENCE OF
EFFECT MODIFICATION BY SELENIUM
Jiancheng Wang1, Huiyuan Guo2, Hao Zhang2, Binyan Wang3, Yan Zhang4,
Jianping Li4, Yong Huo4, Xiaobin Wang5, Xianhui Qin3, Xiping Xu2.
1Renal Division, Nanfang Hospital Southern Medical University China, People’s
Republic of, 2College of Food Science and Nutritional Engineering China Agricul-
tural University China, People’s Republic of, 3Renal Division, Nanfang Hospital
Southern Medical University China, People’s Republic of, 4Department of Cardi-
ology Peking University First Hospital China, People’s Republic of, 5Department
of Population, Family and Reproductive Health Johns Hopkins University Bloom-
berg School of Public Health United States
Objectives: Evidence from epidemiologic studies has been inconsistent regard-
ing the role of vitamin E in cancer incident risk. We aimed to investigate prospec-
tive association between baseline plasma vitamin E levels and cancer risk, and to
identify effect modifiers.
Methods: We employed a nested case-control design, using data from the China
Stroke Primary Prevention Trial (CSPPT), including 229 patients with incident
cancer and 229 matched controls.
Results: The median follow-up duration was 4.5 years. Overall, vitamin E was
not associated with subsequent risk of total cancer (per 1 µg/mL increase: RR,
1.01; 95% CI: 0.93–1.09) and non-gastrointestinal cancer (RR, 1.11; 95% CI:
0.98–1.25). However, we found a significant, inverse association between vitamin
E and gastrointestinal cancer (RR, 0.86; 95% CI: 0.75–1.00), particularly esopha-
geal cancer (RR, 0.61; 0.39–0.97). We further identified plasma selenium as a
significant modifier of the association between vitamin E and cancer risk. High
vitamin E decreased the risk of total cancer (RR, 0.92; 95% CI: 0.84–1.00) and
gastrointestinal cancer (RR, 0.82; 95% CI: 0.71–0.95) among patients with high
selenium levels [≥ 83.7 (median) µg/L], and increased the risk of total cancer (RR,
1.13; 95% CI: 1.00–1.27) and non-gastrointestinal cancer (RR, 1.24; 95% CI:
1.03–1.49) among those with low selenium levels (<83.7 µg/L).
Conclusion: This study suggests that higher levels of plasma vitamin E are associated
with reduced risk of gastrointestinal cancer. A combination of high levels of plasma
vitamin E and high selenium had the lowest risk of cancer compared with other groups.
Keywords: vitamin E, selenium, cancer incidence, antioxidant