MEG properties

Sr.no. Parameters Unit Value Remarks

1 Specific heat Kcal/kg°C 0.58 @25°C
2 Latent heat Kcal/kg
3 Density Kg/m3 1115 @20°C
0.016900 @20°C
4 Viscosity Kg/m.sec
0.005200 @60°C
5 Thermal conductivity Kcal/hr.m.°C 0.22161813 @25°C
6 Electrical conductivity mhos/cm 0.00000107 @20°C
*As per current process max. boil up required is 260 kg/hr of Acetone.
*Hence, Condiering Max. boil up og Methanol of 350 kg/hr, MEG flow rate is taken ofr calculation.

For vapou line sizing & condenser Toluene boil up is considered U/vacuum of 150 Torr

Reactor capacity 8 kl
HTA 17.9 m2

Effective HTA 17.9 m2

U for Glass lined and organ 172 Kcal/hrm2°C
Tmass1 70 °C
Tmass2 70 °C
Tu1 80 °C
Tu2 75 °C
∆T1 10 °C
∆T2 5 °C
∆T1-∆T2 5 °C
LMTD 10.0 °C
Q 30788 Kcal/hr
Heat required 30788 Kcal/hr
Methanol boil up 116.6212121 kg/hr
Say 125.0 kg/hr

Vol. flow rate calc.

P 1 atm
M 32 kg/kmol
R 0.082 lit.atm/k.mol
T 343 K
V.D. 1.137737325 kg/m3
Vol. flow rate 109.8671875 m3/hr
Say 111.0 m3/hr
Vapou line size
Velocity 8 m/sec
ID 0.070069726 meters
ID 70.06972566 mm
Say 150.0 mm

HE sizing Primary
Q1 30788 Kcal/hr
Q2 126.72 Kcal/hr
Total Q 30914.72 Kcal/hr
Tmass1 70 °C
Tmass2 38 °C
Tu1 30 °C
Tu2 34 °C
∆T1 36 °C
∆T2 8 °C
∆T1-∆T2 28 °C
LMTD 18.6 °C
U for graphite HE 425 Kcal/hrm2°C
Area req. 3.907406015 m2
Say 4.00 m2
CW flow 7.73 m3/hr

HE sizing for safety reasons

Reactor capacity 10 kl
HTA 21.1 m2
Effective HTA 16.88 m2
U for Glass lined and organ 301 Kcal/hrm2°C
Tmass1 64 °C
Tmass2 64 °C
Tu1 105 °C
Tu2 101 °C
∆T1 41 °C
∆T2 37 °C
∆T1-∆T2 4 °C
LMTD 39.0 °C
Q 197980.4927 Kcal/hr
Heat required 217778.542 Kcal/hr
Toluene boil up 3350.439107 kg/hr
Say 3359.0 kg/hr
 Solvent properties
Specific heat Latent heat Density Viscosity
Solvents
Kcal/kg°C Kcal/kg Kg/m3 kg/m.sec
Toluene 0.41 90 867 0.000610
Methanol 0.60 264 792 0.000564
Acetone 0.52 125 784 0.000421
IPA 0.64 159 786 0.000421

Time of heating/Cooling
n ofr calculation. Rxn mass 8000 kg
Cp 1 Kcal/kg.°C Time
U 172 Kcal/hrm2°C
A 17.9 m2
Ts 115 °C
T0 30 °C
U/vacuum of 150 Torr T 100 °C
Time 4.507213344 hrs

Celecoxib max. heat load

Distillation of Acetone 500 kg/hr

Heat load 62500 Kcal/hr
TR 20.66798942 TR

Cooling of Rxn mass 174008.25 Kcal

Heat load 14.38560268 TR

QTP max. heat load

Distillation of Toluene 208.08 kg/hr
Heat load 20808 Kcal/hr
TR 6.880952381 TR

Cooling of Rxn mass 11700 Kcal

Heat load 1.547619048 TR

Toluene boil up for HE sizing

Reactor capacity 10 kl
HTA 21.1 m2
Effective HTA 18.99 m2
U for Glass lined and or 301 Kcal/hrm2°C
Tmass1 64 °C
Tmass2 64 °C
Tu1 80 °C
Tu2 76 °C
∆T1 16 °C
∆T2 12 °C
∆T1-∆T2 4 °C
LMTD 13.9 °C
Q 79476.48529 Kcal/hr
Heat required 87424.13382 Kcal/hr
Toluene boil up 971.3792647 kg/hr
Say 978.0 kg/hr

Basis: Utility considered is Hot water & MEG with 15°C temp. difference between

HE sizing Secondary
Q1 30788 Kcal/hr
Q2 126.72 Kcal/hr
Total Q 6182.944 Kcal/hr
Tmass1 65 °C
Tmass2 25 °C
Tu1 10 °C
Tu2 14 °C
∆T1 51 °C
∆T2 15 °C
∆T1-∆T2 36 °C
LMTD 29.4 °C
U for graphite HE 425 Kcal/hrm2°C
Area req. 0.494544769 m2
Say 1.00 m2
CHW flow 1.55 m3/hr

HE sizing Primary for safety reasons

Q1 197980.4927 Kcal/hr
Q2 52400.4 Kcal/hr
Total Q 250380.8927 Kcal/hr
Tmass1 65 °C
Tmass2 40 °C
Tu1 33 °C
Tu2 37 °C
∆T1 28 °C
∆T2 7 °C
∆T1-∆T2 21 °C
LMTD 15.1 °C
U for graphite HE 300 Kcal/hrm2°C
Area req. 55.09549519 m2
Say 56.0 m2
Remarks

M*Cp/U*A((Ts-T0)/(Ts-T))

17424

BUP max. heat load

Distillation of
Methanol 200 kg/hr
Heat load 52800 Kcal/hr
TR 17.46032 TR

Cooling of Rxn mass 135298.8 Kcal

Heat load 44.74167 TR

P 0.197368 atm
M 92
R 0.082
T 333
D 0.664978 kg/m2
mp. difference between rxn mass & jacket temp.

HE sizing Primary Hastealloy HE sizing Secondary

Q1 30788 Kcal/hr Q1 30788
Q2 126.72 Kcal/hr Q2 126.72
Total Q 30914.72 Kcal/hr Total Q 9274.416
Tmass1 70 °C Tmass1 65
Tmass2 38 °C Tmass2 25
Tu1 30 °C Tu1 10
Tu2 34 °C Tu2 14
∆T1 36 °C ∆T1 51
∆T2 8 °C ∆T2 15
∆T1-∆T2 28 °C ∆T1-∆T2 36
LMTD 18.61606 °C LMTD 29.4
U for graphite HE 600 Kcal/hrm2°C U for graph 600
Area req. 2.767746 m2 Area req. 0.525454
Say 3.00 m2 Say 1.00
CW flow 7.73 m3/hr CHW flow 2.32
Hastealloy
Kcal/hr
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°C
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Kcal/hrm2°C
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