Experimental Medicine Immunology; Scientists

at Erasmus University, Department of

Immunology release new data on experimental
medicine immunology
Info publikasi: Immunotherapy Weekly ; Atlanta [Atlanta]18 Apr 2007: 76.

Link dokumen ProQuest

ABSTRAK (ABSTRACT)
"This approach was validated with in vitro proliferation studies. We demonstrate that naive mature B lymphocytes,
but not transitional B lymphocytes, undergo in vivo homeostatic proliferation in the absence of somatic mutations
in the periphery. T cell-dependent B cell proliferation was substantially higher and showed higher frequencies of
somatic hypermutation than T cell-independent responses, fitting with the robustness and high affinity of T cell-
dependent antibody responses.

TEKS LENGKAP
2007 APR 18 - (NewsRx.com) -- Data detailed in "Replication history of B lymphocytes reveals homeostatic
proliferation and extensive antigen-induced B cell expansion" have been presented. According to recent research
from Netherlands, "The contribution of proliferation to B lymphocyte homeostasis and antigen responses is largely
unknown. We quantified the replication history of mouse and human B lymphocyte subsets by calculating the ratio
between genomic coding joints and signal joints on kappa-deleting recombination excision circles (KREC) of the
IGK-deleting rearrangement."
"This approach was validated with in vitro proliferation studies. We demonstrate that naive mature B lymphocytes,
but not transitional B lymphocytes, undergo in vivo homeostatic proliferation in the absence of somatic mutations
in the periphery. T cell-dependent B cell proliferation was substantially higher and showed higher frequencies of
somatic hypermutation than T cell-independent responses, fitting with the robustness and high affinity of T cell-
dependent antibody responses. More extensive proliferation and somatic hypermutation in antigen-experienced B
lymphocytes from human adults compared to children indicated consecutive responses upon additional antigen
exposures. Our combined observations unravel the contribution of proliferation to both B lymphocyte homeostasis
and antigen-induced B cell expansion. We propose an important role for both processes in humoral immunity,"
wrote Zelm M.C. van and colleagues, Erasmus University, Department of Immunology.
The researchers concluded: "These new insights will support the understanding of peripheral B cell regeneration
after hematopoietic stem cell transplantation or B cell-directed antibody therapy, and the identification of defects
in homeostatic or antigen-induced B cell proliferation in patients with common variable immunodeficiency or
another antibody deficiency."
van and colleagues published their study in the Journal of Experimental Medicine (Replication history of B
lymphocytes reveals homeostatic proliferation and extensive antigen-induced B cell expansion. Journal of
Experimental Medicine, 2007;204(3):645-55).
For additional information, contact M.C. van Zelm, Erasmus MC, Dept. of Immunology, 3015 GE Rotterdam,
Netherlands.
Publisher contact information for the Journal of Experimental Medicine is: Rockefeller University Press, 1114 First
Avenue, 4TH FL, New York, NY 10021, USA.
Keywords: Netherlands, Experimental Medicine Immunology, Experimental Medicine, Immunology.

PDF YANG DIBUAT OLEH SEARCH.PROQUEST.COM Page 1 of 3

This article was prepared by Immunotherapy Weekly editors from staff and other reports. Copyright 2007,
Immunotherapy Weekly via NewsRx.com.

DETAIL

Orang: MC, Zelm

Judul: Experimental Medicine Immunology; Scientists at Erasmus University, Department of

Immunology release new data on experimental medicine immunology

Judul publikasi: Immunotherapy Weekly; Atlanta

Halaman: 76

Jumlah halaman: 0

Tahun publikasi: 2007

Tanggal publikasi: Apr 18, 2007

Penerbit: NewsRx

Tempat publikasi: Atlanta

Negara publikasi: United States, Atlanta

Subjek publikasi: Medical Sciences--Allergology And Immunology

ISSN: 10908625

Jenis sumber: Wire Feeds

Bahasa publikasi: English

Jenis dokumen: Expanded Reporting

ID dokumen ProQuest: 213021018

URL Dokumen: https://search.proquest.com/docview/213021018?accountid=25704

Hak cipta: (c)Copyright 2007, Immunotherapy Weekly via NewsRx.com

Terakhir diperbarui: 2010-06-08

Basis data: Consumer Health Database

Hak cipta basis data  2019 ProQuest LLC. Semua hak cipta dilindungi.

PDF YANG DIBUAT OLEH SEARCH.PROQUEST.COM Page 2 of 3

Syarat dan Ketentuan Hubungi ProQuest

PDF YANG DIBUAT OLEH SEARCH.PROQUEST.COM Page 3 of 3