AG-1923 Faculty of Pharmacy B.Pharm. U1 (MUHS) Examination PHARMACEUTICAL MED. CHEMISTRY Sections A&B Time—Three Hours] [Maximum Marks-~80) INSTRUCTIONS TO CANDIDATES (1) Answer THREE questions from Section A and THREE questions from Section B. (2) Question No. 1 and 5 fram Section A & B are compulsory. (3) Discuss the reaction, mechanism wherever necessary, (4) Use pen of Blue’Black ink/refill only for writing the answer books. SECTION—A \. Give the life eyele of malarial parasites; classil'y the antimalarial agents according to their chemical nature. Outline the synthesis of chloroquine. 14 2. Define and classify antiviotics. Write the nomenclature and stereochemistry of Penicillins. Write the synthesis and mechanism of action of any two Penicillins. 13 AWM—T619 l (Comic)3. (a) Write the importance of stereochemustry in bioactivity of drugs iF (b) What is Ferguson principle ? Explain its thearetical aspects in drug action. 6 4. Write notes on — (1) Hypoglycemic agents (2) Antimetabolites. 13 SECTION—B 5. (a) What are antiamoebics ? Give the classification of antiamoebics. 8 (b) Write a note on antifungal agents. 6 6. Describe the mechanism of action, classification and SAR of sulfonamides. Write the uses and synthesis of sulphamethoxazole. 13 7. (a) What are antihelmintics ? Give their classification with suitable examples. g (>) Whnite note on water soluble vitamins. 5 8. (a) Discuss various factors affecting drug metabolism. (b) Mention different metabolic pathways. 13 AWM—76l9 125 be