AG-1922 Faculty of Pharmacy B.Pharm. [11 (MUHS) Examination ORGANIC CHEMISTRY—I1 Sections A & B Time—Three Hours] (Maximum Marks—80 INSTRUCTIONS TO CANDIDATES {L) Answer THREE questions From Section A and THREE questions from Section B. (2) Question No. 1 and 5 from Section A & B are compulsory. G3) Discuss the reaction, mechanism wherever necessary. SECTION—A 1. (a) Write in detail different types of isomerism. (6) Explain geometric isomerism and Z and E system of nomenclature. 14 2. Explain the basicity of pyndine. Give a brief account of nucleophilic and electrophilic substitution reaction in pyridine. 13 AWM—T618 1 (Contd)3, Write the following rearrangement with mechanism and stereochemistry (any FOUR) ;:— 13 fa) (b} (c) (d) (e) Fries rearrangement Benzilie acid rearrangement Pinacel rearrangement Beckmann rearrangement Hofmann rearrangement. 4. White notes on (Any three) :-— 13 a) qi) (iu) (iy) oa (a) (b) 6. (a) AWM —7?618 Hydroboration reaction Molecular rearrangements Meso compounds Conformation of cyclohexane. SECTION—B What are the free radicals ? Give ihe structure and sicreochemistry of free radicals. 14 Outline the synthesis of naphthalene. What is racemic modification ? Give the methods of resolution of racemic modification. 13 Give in detail the difference between 8,1 and S,2 reactions. te (Contd.) 7. Explain the electrophilic aromatic reactions with reference to polycyclic compounds. 13 8. (a) Define steroselectivity and stcrospecificity, 13 (b) White notes on — CO) Catalytic hydrogenation of alkenes, (2) R&S system of nomenclature AWM—T7618 3 125