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Pharm Biol. 2011 Jul;49(7):675-8. doi: 10.3109/13880200903431467. Epub 2011 May 25.

Anti-inflammatory properties from isolated compounds of

Cyclolepis genistoides. Save items
Sosa A1 , Fusco MR, Rossomando P, Juárez A, Robles S, Petenatti E, Pelzer L. Add to Favorites
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Abstract
CONTEXT: Cyclolepis genistoides D. Don (Asteraceae) is an Argentinean endemic shrub,
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known by the vernacular name "palo azul" or "matorro negro". It is widely used in folk
Anti-inflammatory sesquiterpene
medicine as a diuretic, an antirheumatic, and an antispasmodic agent. lactones from[Phytother
Lychnophora
Res. 2013]
OBJECTIVE:  The aim of this work was to describe the activity of two isolated compounds of trichocarpha Spreng. (Brazilian
Anti-inflammatory, antioxidant
C. genistoides, oleanolic acid (1) and deacylcynaropicrin (2), using the carrageenan- and antifungal activity
[PharmofBiol. 2011]
induced paw edema method in mice. Chuquiraga spinosa.
Screening of extracts and
MATERIALS AND METHODS:  Aerial parts of C. genistoides were dried, powdered, and fractions from
[Pak aerial
J Pharmparts
Sci.
of 2008]
extracted with petroleum ether, ethyl acetate, dichloromethane, and methanol for 48 h. The Stachys schtschegleevii Sosn.
Review A review on
fractions obtained from the ethyl acetate extract yielded oleanolic acid, while pharmacology [Nat
andProd
toxicology
Res. 2014]
of
deacylcynaropicrin was obtained according to Abdei-Mogib et al. Structures were Elephantopus scaber Linn.
Review Ethnobotany, chemistry,
elucidated by ¹H-NMR and ¹³C-NMR. The products were administered intraperitoneally at
and biological
[Chem
activities
Biodivers.
of the2012]
doses of 40, 75, and 100 mg/kg. genus Tithonia (Asteraceae).
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 See reviews...
RESULTS AND DISCUSSION:  Compound 1 exhibited significant activity during the first 7 h
of the inflammatory phase (at 1, 3, 5, and 7  h), exercising its inhibitory action on See all...

inflammation mediated by histamine, prostaglandins, serotonin, and kinins, while compound

2 showed a significant inhibition at 3 and 5 h contributing to this effect, acting in the
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intermediate phase.
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CONCLUSIONS: According to the results of this work, the intraperitoneal administration of together
oleanolic acid and deacylcynaropicrin isolated from the aerial parts of C. genistoides
PubChem Compound
produced a significant inhibition of carrageenan-induced inflammation at doses of 75 and
100 mg/kg. These results give support to the use of this plant as an anti-inflammatory in PubChem Compound (MeSH
traditional medicine. Keyword)

PubChem Substance
PMID: 21609303 DOI: 10.3109/13880200903431467
[Indexed for MEDLINE]

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