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AZYGOS VEINS
SYSTEMIC CIRCULATION
MORPHOLOGY
• Dilated tortuous veins
• Distal esophagus and proximal stomach
• Sub mucosal and sub epithelial channels massively
dilated
• Mucosa irregularly protruding into the lumen
• Mucosa normal / eroded and inflamed
• Rupture – massive hemorrhage into the lumen and
hemorrhage into the wall of the esophagus
• Past rupture – venous thrombosis + inflammation
ESOPHAGEAL VARICES
ESOPHAGEAL VARICES
ESOPHAGEAL VARICES
ESOPHAGEAL VARICES
ESOPHAGEAL VARICES
ESOPHAGEAL VARICES
CLINICAL FEATURES
• Asymptomatic / massive hemetemesis
• Death due to massive bleed / hepatic coma
triggered by hemorrhage
ESOPHAGITIS
• GERD / REFLUX
• MUCOSAL IRRITANTS – alcohol, corrosive acids, alkalis, excessive
hot fluids like tea, heavy smoking
• CYTOTOXIC ANTI CANCER THERAPY
• BACTERIA
• HSV VIRUS
• CMV VIRUS
• FUNGAL : immunosuppressed – candida, aspergillus, mucor mycosis
• UREMIA
• RADIATION
• GVHD
• AUTO IMMUNE DISEASES
• PEMPHIGOID AND BULLOUS DISORDERS OF SKIN
• CROHN DISEASE
• DRUGS
GASTRO ESOPHAGEAL REFLUX
DISEASE (GERD) OR REFLUX
ESOPHAGITIS
• Reflux of gastric contents into lower esophagus
most important cause
• Reduced LES tone / decreased efficiency of
anti reflux mechanisms
- CNS depressants
- Hypothyroidism
- Pregnancy
- Systemic sclerosing disorders
- Tobacco exposure
- Nasogastric tube
GERD
• Hiatal hernia – especially sliding
• Inadequate / slow clearance of refluxed
material
• Delayed gastric emptying
• Increased gastric volume
• Reduced reparative capacity of esophageal
mucosa by protracted exposure to gastric
juices
• Gastric juices +/- bile from duodenum
MORPHOLOGY
• Inflamed esophagus – “redness”
• Inflammatory cells in the epithelial layer –
eosinophils, neutrophils, lymphocytes
• Basal zone hyperplasia
• Capillary congestion in lamina propria with
elongation of papillae
CLINICAL FEATURES
• Dysphagia
• Heartburn
• Regurgitation of sour material
• Hemetemesis
• Melena
• Chest pain
CONSEQUENCES
• Bleeding
• Ulceration
• Stricture formation
• Barrett esophagus formation
BARRETT ESOPHAGUS
• It is the metaplastic change occurring in the
distal esophageal epithelium where in the
squamous epithelium is replaced by
metaplastic columnar epithelium.
• GERD IS THE SINGLE MOST IMPORTANT
CAUSE
• BARRETT ESOPHAGUS IS THE SINGLE
MOST IMPORTANT RISK FACTOR FOR
THE DEVELOPMENT OF
ADENOCARCINOMA
CRITERIA
1. Endoscopic evidence of columnar epithelial
lining above the gastro esophageal junction
2. Histologic evidence of intestinal metaplasia
in the biopsy specimens from the columnar
epithelium
CLASSIFICATION
1. SHORT SEGMENT < 3cm cephalad
2. LONG SEGMENT > 3cm cephalad from
the manometric gastro esophageal junction
ENDOSCOPIC VIEW OF
ESOPHAGEO GASTRIC JUNCTION
BARRETT ESOPHAGUS
BARRETT ESOPHAGUS
BARRETT ESOPHAGUS
BARRETT ESOPHAGUS
NORMAL GASTRO ESOPHAGEAL
JUNCTION
HISTOLOGY
• Definitive diagnosis is made when the
squamous epithelium is replaced by
columnar mucosa
• Also the columnar mucosa contains
intestinal goblet cells
• Low or high grade dysplasia can be present
BARRETT ESOPHAGUS
BARRETT ESOPHAGUS-
DYSPLASIA
TUMORS OF ESOPHAGUS
• BENIGN:
1. EPITHELIAL
- Squamous cell papilloma
- Adenoma
2. MESENCHYMAL
- Leiomyoma
- lipoma
Tumors
• MALIGNANT
1. EPITHELIAL:
- Squamous cell carcinoma
- Adenocarcinoma
2. MESENCHYMAL
- leiomyosarcoma
CARCINOMA ESOPHAGUS
• Usually diagnosed late
• Aggressive spread
• Men > 50 years of age
• Varied incidence world wide
• Chinese and japanese common
• Bad prognosis
RISK FACTORS FOR CA
ESOPHAGUS
1. ESOPHAGEAL DISORDERS:
- Long standing eophagitis
- Barrett esophagus
- Achalasia
- Hiatus hernia
- Diverticula
- Plummer Vinson syndrome
2. DIET AND LIFE STYLE
- Smoking
- Alcoholism
- Deficiency of vitamins A,C, riboflavin,
thiamine, pyridoxine
- Trace element deficiency – zinc,
molybdenum
- Fungal contamination of food stuff
- High content of nitrites / nitrosamines
3. GENETIC FACTORS:
- Tylosis : hyperkeratosis of palms and soles
- Inherited defects of cancer
MORPHOLOGY
• Squamous cell carcinoma and
adenocarcinoma are the 2 common types
• SCC comprises almost 90% of cases
• Elderly men
• Most common in mid esophagus – 50%
lower esophagus – 30%
upper esophagus – 20%
PRECURSOR
• DYSPLASIA CARCINOMA IN SITU
INVASIVE CANCER
• BARRETT ESOPHAGUS LOW GRADE
DYSPLASIA HIGH GRADE DYSPLASIA
INVASIVE ADENOCARCINOMA
SCC
1. Polypoid fungating type
2. Ulcerating type
3. Diffuse infiltrative type
MICRO : well differentiated to poorly
differentiated squamous cell carcinoma
ADENO CARCINOMA
• Usually arises in a setting of Barrett
esophagus
• Lower and mid esophagus common sites
• Nodular, elevated masses in lower
esophagus
MICRO :
Most of them are well differentiated mucin
producing tumors
CLINICAL FEATURES
• Weight loss
• Anorexia
• Fatigue
• Weakness
• Pain during swallowing
• Dysphagia
• Spreads very soon because of the extensive
lymphatic network
CARCINOMA ESOPHAGUS
CARCINOMA ESOPHAGUS
CARCINOMA ESOPHAGUS
CARCINOMA ESOPHAGUS
CARCINOMA ESOPHAGUS
CARCINOMA ESOPHAGUS
CARCINOMA ESOPHAGUS
CARCINOMA ESOPHAGUS
CARCINOMA ESOPHAGUS
CARCINOMA ESOPHAGUS
SQUAMOUS CELL CARCINOMA
ESOPHAGUS
CARCINOMA ESOPHAGUS -
STAGING