Cell Line Development Services Global Market

–Forecast to 2027

Cell line development Services Global Market estimated to be $1,519.5 million

by 2027

IQ4I Research & Consultancy published a new report on “Cell Line Development
Services Global Market – Forecast To 2027” This report analyzes and studies the overall
market, major Drivers & Opportunities, Restraints & Threats in North America, Europe, Asia-
Pacific and Rest of the World

IQ4I’s Report Contains 43 market data tables and 39 figures spread through 201 pages
and an exhaustive TOC on “Cell-line Development Global Market”, [Cell Line
Development (Expression system {Mammalian, Microbial and Others}, Cell type {CHO,
Hybridoma, Mouse myeloma [NSO;Sp2/0], Human Embryonic kidney [HEK], Baby Hamster
Kidney [BHK], Human Embryonic Retina [PER.C6] and Others}, & Application
{Bioproduction, Research and Diagnostics}); Regional (North America, Europe, Asia Pacific
& Rest of the World)]

Cell lines are one of the major tools used in research for studying the normal physiology and
biochemistry of cells, the effects of drugs and toxic compounds on the cells, drug screening,
development and large scale manufacturing of biological compounds. Cell culture is the
process by which cells are grown under controlled conditions derived from microbial or
animal cells. Cell lines are subculture of primary culture also known as sub-clone. Cell lines
derived from primary cultures have a limited life span, after subsequent cultures, cells with
the highest growth capacity dominate which are selected for further cell development.
Primary cells are cells that are cultured directly from a subject and have a limited lifespan.
An immortalized cell line can proliferate indefinitely either through random mutation or
deliberate modification which are useful especially for production of therapeutics.

The cell line development service market is expected to grow at a CAGR of 11.3% to reach
$1,519.5million by 2027. Increasing demand for biologics and biosimilars, growing incidence
rate of oncology and immunological disorder and growth in research activities related to the
diseases are driving the market. Technological improvements in development,
manufacturing, screening technologies and assays are giving immense growth opportunity
for the market. However, complexities in development of stable cell lines and high risk of
contamination due to complex purification methods are restraining the market. Furthermore,
stringent and complex regulations and high cost and technical requirement to adhere with
accreditations such as GMP are posing threat to the industry.

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Cell Line Development Services Global Market

–Forecast to 2027

Cell lines are essential for a wide range of applications including gene function studies, drug
discovery assays, the production of biotherapeutics and diagnostics. The application for cell
lines includes research, bioproduction and diagnostics. Among research, cell lines are used
for studying disease, screening, cell-based assays are used during discovery phase and
preclinical development. Cell lines are used to produce a wide range of biotherapeutics
including vaccine, recombinant proteins that include peptides, cytokines, hormones and
clotting factors, enzymes and monoclonal antibodies.

Biotherapeutics including monoclonal antibodies, peptides, recombinant proteins, vaccines,

blood related products are produced in a wide variety of platforms, including non-mammalian
expression systems (bacterial, yeast, plant and insect) and mammalian expression systems
(including human cell lines). However, the most appropriate expression system to be used
is dependent on the type of biopharmaceutical to be produced. Microbial systems are used
for producing relatively simple recombinant proteins such as insulin or antibody fragments.
They are attractive due to their low cost and high productivity. E. coli and S. cerevisiae are
the most commonly used microbial systems. However, many biopharmaceuticals including
mAb’s, highly glycosylated proteins or recombinant proteins are large and complex,
mammalian cell lines are the most preferred platform used for manufacturing them. Post-
translational modifications including glycosylation, carboxylation, hydroxylation, sulphation,
amidation are a significant factor to select the type of cells to be used. Among them,
glycosylation is the most common modification. Mammalian expression system commanded
the largest revenue of the global cell line development services market, by expression
system in 2018. The market is expected to grow at double digit CAGR. The most common
mammalian cell cultures used for production of biopharmaceuticals include Chinese hamster
ovary (CHO) cells, baby hamster kidney (BHK21) cells, Human embryonic kidney 293 cells,
Hybridoma and murine myeloma cells (NS0 and Sp2/0).

Among cell line type, CHO cell line is the most frequently used mammalian system, which is
used in the manufacture of most of the currently approved biologics. CHO cell lines market is
expected to grow at high double digit CAGR. CHO cells have been the industry’s cell line
workhorse for production of biopharmaceuticals. These cell line has several major
advantages being versatile, relatively easy to work with, having well-understood
glycosylation patterns. Approximately 36 monoclonal antibodies and 8 recombinant proteins
are produced using CHO cell lines. Murine Myeloma are expected to occupy second largest
share.

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Cell Line Development Services Global Market

–Forecast to 2027

The increasing demand for biologics and biosimilars has increased the demand for
production cell lines. The expiration of blockbuster biologics has also driven the emergence
of biosimilars. Companies are working to produce efficient and less time consuming
expression systems and also using automation and robotics in screening of cell lines to
speed up the process. The SUREtechnology platform by JSR Life Sciences (Selexis S.A)
(U.S) has been able to generate stable and high performing cell lines in three months with
productivity levels of 1-7 g/L for monoclonal antibodies and about 76 drugs in clinical phase
and 3 marketed drugs have been developed.

The increasing demand for cell line development service has fostered many companied to
start offering CDMO services related to biologics either through organic expansion or though
mergers, agreements or acquisitions. For instance, JSR Life Sciences, the life-sciences
focused division of JSR Corporation, aquired Selexis SA, a pioneering life sciences company
and global leader in mammalian (suspension-adapted CHO-K1) cell-line generation
technologies. ATUM has announced an expansion of its services to include cell line
development using the company’s proprietary Leap-In Transposase genome engineering
tools. Sartorius Stedim which is a leading provider of cutting-edge equipment for the
development and production processes of the biopharmaceutical industry acquired
BioOutsource and Cellca in 2015 to provide contract research services in cell line
development and testing for biopharmaceuticals.

Some of the major companies in the cell line development market include Lonza
(Switzerland),Fujifilm Diosynth (Japan) , Merck KGaA (Germany), JSR Life Science (Selexis)
S.A. (U.S), Rentschler Biotech (Germany), Horizon Discovery (U.K.), Sartoris Stedim
(France), Wuxi Apptec (China), Boehringer Ingelheim (Germany), Eurofins (Luxembourg )
and Cook Pharmica (U.S.).

Some of the other players are Patheon (The Netherlands), Syngene (India), Crown
Bioscience (U.S.), Evotec (Germany), Catalent (U.S.), Lake Pharma (U.S.), TCG Lifescience
(India), Cobra Biologics (U.K.), Abzena (U.K.), JHL Biotech (Taiwan), Charles River
Laboratories (U.S.), Genscript (China), Mabplex (U.S.), Trenzyme (Germany), Atum (U.S.),
ATCC (U.S.).

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Cell Line Development Services Global Market

–Forecast to 2027

Reasons for buying this report:

• In depth assessment of all segments and sub segments of cell line development
services global market.

• Regional analysis of cell line development services global market.

• Market dynamics for cell line development services global market.

• Cost analysis of different cell line development services and cell based assays.

• Cell line type used in approved biologics (2012-2018) and analysis based on type of
modality.

• Comparison matrix of various key players with cell line development capabilities.

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