AO Start Up Grant Application Form 2015 3

S-15-
AO Start-up Grant Application
Before you submit your grant application
Please check our website

www.aofoundation.org
before beginning.
Use the latest grant application form which can be downloaded from our website.
Please review the guidelines before beginning.
Applications which do not conform completely to the website application format or which ignore or fail to
comply with any part of the guidelines may be returned to the applicant and will not be considered unless
resubmitted by the deadline.
Please check that

 your application does not exceed the allowed number of pages/word/characters as indicated on the
following pages
 all amounts must be converted to Swiss Francs
 your calculations are correct and all totals are entered
 we need written and signed confirmation signed by the head of your institution if you applied for salary
support for yourself or a co-investigator
 we need written and signed confirmation for collaboration with the AO Research Institute, Davos
(Switzerland) and AO Clinical Investigation & Documentation Department (CID). Only required if you plan
a cooperation with one of these departments.
Please be reminded that

The project duration is strictly limited to 24 months. Be realistic with your timetable as no-cost extensions will
not be approved. If an approved study is not completed by the defined end date, the final installment of 20%
will not be paid.
Please submit your application

 as an unprotected Word-document to anita.anthon@aofoundation.org
You will receive

 a confirmation e-mail within a week regarding receipt of the application. Should you not receive the
notification within one week, please contact: anita.anthon@aofoundation.org
 a notification email on the decision approximately six months after the respective deadline
1
S-15-
AO Start-up Grant Application
Part 1: General information
Type of application ☒ New application ☐ Continuation of project no

Research field Research field of the proposal Field of the institution of the principal
investigator
Select here:ClinicalClinical Select here:Select here:
AO Clinical Divisions Please select one particular area in which your grant application best fits:
☒☐AOCMF ☐AOSpine ☐AOTrauma ☐AOVET ☐Others/General
Project title Analysis of the adhesion of the soft tissues in the materials of
Do not exceed 100 characters polyamide 12, PEEK, PMMA DME3D for imaging and and its
beneficial cost determination Cranioplasty
Total amount requested in Swiss Francs CHF $ 60.000
Duration / Start date Duration: 12 months12 months Start date: Click here to enter text.
Type of research Involving human subjects (eg, clinical studies) Involving human subjects
(eg, clinical studies)
Keywords Click here to enter text. Click here to enter text.

Provide at least 3 keywords describing the topic Click here to enter text. Click here to enter text.
of your proposal Click here to enter text. Click here to enter text.
Principal investigator
Surname / First name / Age in years Castaneda Muñoz/ Diego Ferney/ 40Castaneda Muñoz/ Diego Ferney/ 40 Formatted: Font: Not Bold
Academic degrees Magister in Mechanical Engineering
Current employing institution DCM Engineering Services S.A.S
Young researcher as described in our guidelines:
☐ yes ☐ no
Co-Investigator 1
Surname / First name / Age in years Click here to enter text.
Academic degrees Click here to enter text.
Current employing institution Click here to enter text.
Co-Investigator 2
Co-Investigator 3
Co-Investigator 4
Co-Investigator 5
2
Young applicant’s career focus
Please indicate how this grant, if funded, will help your career desires and focus. Outline your
expected career path and how this aligns with the AO Start-Up Grant program guidelines.
Do not exceed 250 words.
Click here to enter text.
3
Part 2: Personal data
Do not exceed 1 page per applicant and do not send a separate CV
Principal investigator
Surname / First name / Age in years Castañeda Muñoz/Diego Ferney 40
Academic degrees Magister in Mechanical Engineering
Present position and title Administrative Assistant
Institute / Department DCM Engineering Services S.A.S/Administrative
University / Institution University of Valle, Cali-Colombia -Sudamerica
Office address (please provide full postal address) Street 7 No. 20 -13
e-mail Diegocamu2008@gmail.com
Education / Training
Begin with baccalaureate or other professional education and include postdoctoral training
Institution and location Degree Year (date) Field of study
National school Santa Librada Academic Bachelor 2000 Academic
University of Valle Mechanical Engineer Formatted: Centered
2001 Biomechanics
University of Puerto Rico at Mayagüez Magister in Sciences Formatted: Font: 8 pt, Font color: Auto
of Materials 2003 Biomaterials / Biomechanics
Formatted: Font: 8 pt, English (United States)
Formatted: Centered
Position and employment
Year (date) Position Institution and location
May/2000 student researcher University of Valle Formatted: Centered
May/2003 Researcher and professor University of Puerto Rico at Mayagüez
Formatted: Centered
August /2004 Researcher and professor University Pontificia Bolivariana
Formatted: Centered
Sectional Santander
Pioneer de Colombia Sdad Ltda Formatted: Font: 8 pt
Formatted: Spanish (Colombia)
Other experience and professional membership
Year (date) Position Institution and location Formatted: Spanish (Colombia)
2004 Assistant manager. Soil Engineering and Environment Formatted: Centered
Maintenance Coordinator
2009 Operations Engineer - ECOPETROL - GEOINGENIERIA Formatted Table
Interventor in oil drilling
2013 Field Operations Engineer Ecopetrol-Consultec International
Drilling Formatted: Centered
2014 Trainer Hydrocarbons Human capital development s.a.s. - hcd
Area Formatted: Spanish (Colombia)
Formatted: English (United States)
Honors Formatted: Font: 8 pt, Not Bold
Year (date) Description
Formatted: Centered
Formatted: Centered
Formatted: Font: 8 pt
4
Co-investigator 1
Present position and title Click here to enter text.
Institute / Department Click here to enter text.
University / Institution Click here to enter text.
Office address (please provide full postal address) Click here to enter text.
e-mail Click here to enter text.


Honors
5
Co-investigator 2


Honors
6
Co-investigator 3


Honors
7
Co- investigator 4


Honors
8
Co- investigator 5


Honors
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Part 3: Details of the proposal
This part must not exceed 10 pages / Do not change the font (Arial 10).
1 Project abstract
Please summarize the whole project. The abstract must be suitable to stand alone as, in case of
approval, it will be published on our website.
Do not exceed 2500 characters including spaces.

Traumatic brain injury is a major cause of morbidity and mortality in our country and the world. The reasons
presented are more traffic accidents, occupational or domestic, falls, assaults, abuses, sports risk practices,
etc. About 50% of those who suffer an accident, have a craneal1 trauma. They attend various situations that Formatted: Superscript
deprive people for cephalic skull injury (TBI) leading to an impairment of the brain caused by an external force
that can cause a decrease or dysfunction of the level of consciousness and leads to impaired cognitive, physical
and / or skills emotional individual, as well as the aesthetics. The TCE represents a serious health problem and
is the most common cause of death and disability in young people, without major economic repercussions
related.
Currently there are biomaterials used as implants in craneoplasty that can recover 90% protecting the brain,
after carrying out a follow-up treatment that focuses on minimizing secondary damage optimizing cerebral
perfusion and oxygenation and prevent or treat non-neurological morbidity.
This project aims to show an analysis of biocompatibility of biomaterials Poliamida 12, PEEK, PMMA DME3D,
BONE, radiologic images and which of these materials is the most cost beneficial for patients with severe head
trauma undergoing surgery for cranial decompression They are needing a cranioplasty.
In order to achieve the objectives, some research groups accompany the project contributing their expertise in Formatted: Justified
this regard; among these are the University of Antioquia, University of Pittsburgh-US, forming an important
interdisciplinary group as a generator of new knowledge, as a transmitter of this knowledge to the medical
society and a strengthening of their own research capabilities
2 Outline the problem
The skull of the human body is a part of the axial skeletal system. The axial skeletal system is the center of the Formatted: Justified
human body and consists of the skull, chest and ribs and spine. This system protects the body parts required
for everyday functions as the brain, the central nervous system, spinal cord and most of the internal organs like
the heart and lungs. The skull protects the most important for the functioning of vital body organ, the brain.
Surgeons throughout the ages have sought ideal for use in the reconstruction of the skull material. These
biomaterials have excellent physical and chemical properties of biocompatibility; therefore they should be widely
available and what material is the most cost beneficial for patients with severe head trauma undergoing surgery
for cranial decompression need a cranioplasty?, while autologous bone is widely used and favored in
contemporary reconstructive procedures , synthetic alternatives have been used throughout history and it is
necessary in the current practice of selected autograft reconstruction is not an option (such as cases with severe
bone crushing, resorption of the bone graft, infection and other disorders cases that may occur) 2 The use of
synthetic materials, when necessary, has been functional. Over time, this search has led to the use of metals,
ceramics, plastics, polymers and later resorbable biomaterials and craniofacial reconstructions.
An essential component in the rehabilitation process of decompression cranioplasty in a patient with severe
skull damage, involves replacing the damaged part flap or bone for implant material known as biomaterial.
Create a standardized in vitro method (in vivo correlation) to quantify adhesion of a soft tissue to a surface. That Formatted: Font: Not Bold
would help a lot to medical device manufacturers streamline the process of creating new devices, materials,
surface finishing methods and similar technologies related to soft tissue adhesion.
3 State of the art in this field
10
Biomaterials are one of the most important advances in modern medicine, a multidisciplinary field that attacks
many problems in medicine and biology with the tools and methods used in various areas of engineering.
Skull trephines, the oldest surgical procedure known, were practiced by many ancient civilizations. In Peru there
is ample evidence that the pre-Inca “surgeons” carried out this treatment 3000 years before Christ.
Trephined Inca skulls have been found along side gold and silver shells and plates. There is also evidence of
skulls with these materials placed in situ covering the cranial defect. The most notable example is a skull dated
2000 B.C. found in hill Colorado (Paracas zone, Perú).1 It had a left frontal defect that was covered with a 1 mm
thick plate of gold. It has been mentioned that in these civilizations reconstruction with precious metals was
reserved for the highest social class, while the use of weaker or more common elements was used for the lower
social class.
In Celtic Neolithic culture, rounded or oval skull fragments have been found presumably from trephined skulls.
On occasions they had a central orifice in the shape of a “ring”, which had certain magical properties. A skull
found in Crichel Down ( United Kingdom,1938) had a large ring that had been placed in the original trephined
cavity. The skull margins showed no signs of healing, to the extent that the cranioplasty could have been carried
out postmortem. It shows, nevertheless, that the cranioplasty concept was not unusual in ancient European
cultures.
The first successful cranioplasty using a bone graft was recorded by Job Janszoon van Meekeren, a Dutch
surgeon who treated a Russian noble who had lost part of his skull after being struck with a sword. The
reconstruction was carried out with a fragment of bone from a dead dog that was adapted to the defect. When
the competent authorities at the time heard of this, the patient was banished from the country but no measures
were taken against the surgeon.1
A great variety of materials have been used throughout history for the reconstruction of cranial defects. As from
the last century attempts have been made to find the ideal bone substitute and some characteristics have been
described such as resistance, malleability, heat non-conductive, sterilizable, inert, radiolucid, non-magnetic,
disposable and cheap. Without any doubt, metallic bone substitutes are a great advancement with regard to the
biomaterials available for cranial repair. Aluminum was the first metal in recent history to be used. Initially
described by Booth and Curtis (1893),2 considerable tissue reaction occurred. It was epileptogenic and slow
disintegration took place, to the extent that its use did not become generalized.
Tantalum was first described in 1802. It was proposed as a cranioplasty agent in 1942, after experiments in
dogs showed no tissular reaction. It is radiopaque and the postoperative imaging tests were difficult to evaluate.
Its use was substituted by acrylic components and by titanium.
Titanium is an element that was first discovered in 1796, but it was not commercially available until 1946, after
the reduction process of titanium tetrachloride. In 1965 Simpson was the first to use it in cranial reconstruction.
Compared with tantalum, it is much more radiolucid and considerably less expensive. Other advantages are its
biocompatibility and high mechanical resistance. It is inert, non-cancerous and non-allergic.
During World War II, a great number of cranial defects were produced. Although tantalum was one of the
materials of choice in this era, there was growing interest in acrylic resins. Just after the end of World War II
these resins were used as material for dental prostheses with good results. It was then suggested that they
could play an important role in cranial reconstruction. One of the initial advantages was a greater radiolucency.
Methyl methacrylate was then discovered in 1939. Among its qualities was a great resistance to stress and
heat. It is an inert metal and it was first used in an experimental way as cranioplasty material in a rat in 1940.
Zander1 was the first to use it in humans in October of the same year. Titanium was first used by Simpson for
cranioplasty in 1965. During the twentieth century was the further development of materials alloplastic for repair
skull defects. The methylmethacrylate It was introduced in 1940. Titanium was first used by Simpsom a
cranioplasty for 1965.
Many desirable properties have been described with regard to biomaterials, although the ideal characteristic
has not been found. Among these there is biocompatibility, strength, resistance to fractures and to thermal
conduction. It should also be inert, sterilizable, low cost, radiolucent, and malleable it should have osteoactivity3.
Note that both are still discovering new polymers such as polyamides whose trade name is the Nylon,
discovered in 1928 by Carothers and directing team working on the DuPont 4; the politetraflouretileno whose
trade name is Teflon, coincidentally was born thanks to Roy S. Plunkett when he worked for DuPont in 1938 5
, this material is characterized by withstand temperatures up to 300 °C. It will also laying the foundation on which
new born, all at an increasingly frenetic pace. It will also laying the foundation on which new born, all at an
increasingly frenetic pace.
11
"Recently, DuPont has provided two polyimide resins, and called AVAMID AVAMID-K-N, which are excellent
thermoplastic matrices with high mechanical strength at elevated temperatures, good resistance to introducing
damaged by use. Preferably begin to be used in aerospace and military applications " 6.
Is the science of internal plastic in other areas: surface modification of the new polymers are studied to enhance
biocompatibility with the human body, such as arise biopolymers produced by bacterial fermentation as
polyhydroxybutyrate (PHB) produced by bacterial fermentation of "Alcaligenes eutrophus". On the scene
conducting polymers, thermochromic polymers, piezoelectric polymers, liquid crystal polymers, reinforced
braided materials are investigated. New born fibers and filaments from a variety of polymers, eg, fiber-called
Spectra 900 Allied Chemical, a polyethylene based fiber developed between 1985 and 90, is lighter, resistant
and adhesiveness improved.
4 Past research of the applicant in this field
Research from 1992-2011 and perspectives on the development of biocompatible materials have not only
focused its efforts on achieving a good interface between living tissue and material to be implanted, so that is
not rejected by the body concerned , but they have also sought greater levels of functionality by the implanted
materials, varying its characteristics through multiple processes such as modification of the surface, in order to
achieve greater and better integration with the body by decreasing cytotoxicity, increased cell viability and, in
the case of implants for bone replacements, leading biomineralization.
The fundamental role of the surface and the surface characteristics of the biomaterial, so that it will react and
adapt to living systems in a more suitable manner, for example by increasing the surface roughness increased
cell adhesion is observed stands.
Technological advances that are taking place in recent years biomaterials have been developed to meet specific
requirements in different clinical applications. Authors like Ikada, 7 Meyer,8 Estrada9 and Barrere10 describe the
materials for bone implants should observe the following properties:
Biocompatibility: integrated into the host organism without any cytotoxic, genotoxic or immune response. This
is a fundamental property of biomaterials.
Biodegradability: degraded (by hydrolysis) at rates that are as close as possible to the rates of new bone
formation. This is a challenge to the biocompatilidad because the degradation products must not be toxic.
Resistance and mechanical compatibility: withstand mechanical loads depending on the position of the bone
tissue it replaces. The mechanical properties such as modulus of elasticity, the tensile strength, fracture
toughness, fatigue and elongation percentage, among others, should be as close as possible to the tissue being
replaced (mechanical compatibility) to prevent osteopenia associated with the use of bone grafts or "stress
shielding".
Osteoinductivity: fixing promote the formation of specific cells in the bone tissue. This is achieved by recruiting
osteoprogenitor mesenchymal stem cells and to subsequently proliferate and differentiate into the osteogenic
line.
Osteoconductivity: act as structural support in the formation and growth of new bone. This property is combined
with the biodegradability because the implant material must be reabsorbed to make room for the new tissue that
initially helped support.
Radiolucency: differentiate radiographically relative to the tissue where it is implanted.
The development of tissue engineering in the area of biomaterials compliant materials exhibits a greater or
lesser extent these properties. There are families of materials with characteristics that make them useful for a
specific range of clinical applications so depending on the application you must select the biomaterial.
Development of custom implants according to the physical characteristics of each patient, can restore the
anatomic area by creating a patient interface more effectively and because of its pre-production, reduce
operating time and risk of infection to the patient you may experience during the surgical procedure.
The overall infection rate approaching 5% according to different studies. However, Manson, 11 shows a complete
success without infection in their series of 42 cranioplasty with methyl methacrylate. Patients with simultaneous
cranial reconstruction, orbital or nasal have an infection rate of 23%. Patients who develop infections have
previously presented implant infection of the area where the methyl methacrylate is placed. For Manson said
material of choice in adult patients with good quality soft tissue without previous history of local infection.
5 Open questions, hypothesis, aim of the project
5.1 Open questions
12
That material is more cost beneficial for patients with severe head trauma that will cranial surgery for
decompression and need a cranioplasty?
5.2 Hypotheses
The objective of this research is to evaluate the biocompatibility of the material impact on the skull, where we
have two evaluations; an imaging medical evaluation and a purely implant.
5.3 What are the aims you want to reach with your study?
- That stuff is and more cost-beneficial for patients with severe head trauma undergoing surgery for cranial
decompression need craneoplasty.
- Assessment process due to the impact of the material on the skull where we two assessments:
1. A medical evaluation imagenological

2. Clearly other implant
5.3.1 Anticipated results for year 1

Describe in a few sentences the anticipated results and goals for the first year
Determine analysis of soft tissue adhesion to the surface of the biopolymer materials PEEK, Polyamide 12
PMMA DME3D and cost-beneficial for severe head trauma patients undergoing surgery for cranial
decompression tissue need a cranioplasty.
5.3.2 Anticipated results for year 2 (if applicable)

Describe in a few sentences the anticipated results and goals for the second period not exceeding 6 months
6 Detailed research plan
6.1 Study subjects, specimen or materials
Analysis of soft tissue adhesion to the surface of PEEK materials, PMMA DME3D and Poliamida12 by
Imaging
6.2 Effect and outcome variables
6.3 Methods for taking measurements
Three groups of 10 patients with three different materials each selected implant. This group of thirty (30) patients
which has taken away the bone, where some patients will have bone saving and others are not, the method of
randomization was used, about with PEEK material PMMADME3D others, others with Poliamida12 and others
bone. When performing implant surgery the patient under observation is left for three (3) months, six months
and if there is any patient who has to withdraw these six months any implant this implant will be an analysis of
the material to see what kind of evolution he had the material with respect to analysis of a soft tissue adhesion
to the surface. And the twelve (12) months perform the functional evaluation with the results of the three (3)
lines of implants and an analysis or hypothesis about the bone to see if will present more complications than
prosthetic material be made, which It will be known during clinical monitoring during the course of the
investigation.
6.4 Methods for data management and analysis (including biostatistical check)
6.5 Estimation of sample size and power
13
6.6 Animal model
If an in vivo animal model is used in the planned research work, please describe the model in detail. The
description should include: anesthesia protocols, treatment protocols, pain management, surgical techniques,
post-operative care, criteria for removal from the study if necessary, and euthanasia protocols.
AAALAC accreditation (Association for assessment and accreditation of Laboratory Animal Care International)
www.aaalac.org
Please indicate whether the institution (main applicant and co-applicants) is AAALAC accredited and specify in which
institution the animal research will be carried out. If the institution is not AAALAC accredited, please detail what agency
and standards are used to oversee animal use and care.
7 Relevance of the project
8 Time schedule
Formatted Table
MONTHS Formatted: Centered
ACTIVITY 1 2 3 4 5 6 7 8 9 10 11 12 Formatted: Centered

Formatted: Tab stops: 0.12", Centered
Phase 1.
Random Classification of Formatted: Centered
implant materials peek-
PMMADME3D- ELI Titanium
used in patients with severe
trauma they need cranioplasty
craneocefalic.
Phase 2. Surgery patients with
severe head trauma that
required cranioplasty with
random classification of implant
materials used as PEEK-
PMMADME3D- Poliamida12.
Phase 3. Imagenological
randomization process of
assessment, analysis of a soft
tissue adhesion to the surface
and clinical monitoring in severe
head trauma patients who need
cranioplasty of the three lines of
implant materials used as PEEK
and Poliamida12
PMMADME3D-ELI
14
and Poliamida12
PMMADME3D- ELI.
and Poliamida12- PMMA
DME3D- ELI.
Phase 6. Conclusions and / or
Recommendations
9 Relevant literature
9.1 By the investigators
9.2 By other authors
1. Sanan A, Haines S. Repairing holes in the head: a history of craneoplasty. Neurosurgery 1997; Formatted: Justified, Indent: Left: 0", Hanging: 0.25",
40: 588-603. Space Before: 0 pt, After: 0 pt, Pattern: Clear, Tab stops:
0", Left + 0.13", Left
2. Booth JA, Curtis BF. Report of a case of tumor of the left frontal lobe of the cerebrum:
Operation-Recovery. Ann Surg 1893;17:128-39.

3. Gerster AG. Heteroplasty for defect of skull. Trans Am Surg Assoc 1895;13:485-6.
Field Code Changed
4. Richardson & Lokensgard. “Industria del plástico”. Ed. Paraninfo. Madrid, 2002. Pag.494. Formatted: Hyperlink, Font: 9 pt, Spanish (Colombia)
5. http://es.wikipedia.org/wiki/ polytetrafluoroethylen 8/11/2007 a las 16:35 Formatted: Hyperlink, Font: 9 pt, Spanish (Colombia)
15
6. Melero Columbrí, F.J.” Advanced materials and processes”. Editorial Dayton. Madrid, 1993 Formatted: English (United States)
7. Ikada DE. Challenges in tissue engineering. En Journal of The Royal Society Interface. 01/11/2006;3(10):589-
601
8. Meyer U, Meyer TH, Handschel J, Wiesmann HP. Fundamentals of tissue engineering and regenerative
medicine. New York: Springer; 2009.
9. Garzón AA. Ingeniería de tejido óseo: Consideraciones Básicas. Revista EIA. 2006;5:93-100. ISSN 1794-
1237.
10. Barrère GU, et al. Advanced biomaterials for skeletal tissue regeneration: Instructive and smart functions. J
Materials Science and Engineering. 2008;59:38-71.
11. . Manson P,Crawley W,Hoopes J. Frontal craneoplasty: risk factor and choice of cranial vault
reconstructive material. Plast Reconstr Surg 1986;77:888.
Formatted: Indent: Left: 0", Hanging: 0.25", No bullets or

numbering

Formatted: Line spacing: single, Don't adjust space
between Latin and Asian text, Don't adjust space between
Asian text and numbers
16
Part 4: Other support
If any other funding has been, is or may be received for this study, its source and amount should be
declared here.
Is this application currently being submitted elsewhere?

☒ Yes ☐ No
If yes, to which organizations, and by what date is a decision expected?
Submitted to Amount requested Decision expected
Please give details of how this affects the study and declare the budget. If there could be a duplication of
funding received from the AO Foundation a revised budget should be submitted.
Has this or a similar application been submitted elsewhere over the past year?
If yes, please give details, and explain how this does not overlap with your current application to the AO
Foundation.
Submitted to Decision Amount requested Amount approved
17
Part 5: Finances — Budget for entire proposed project period
Please note that the amounts must be converted to Swiss Francs.

For salary requests for principal and co-investigators please check the AO Start-up Grants Guidelines.
Personnel
Surname / First name Academic qualification Effort in % Year1 Year2 Total
Original currency Swiss Francs Original currency Swiss Francs Swiss Francs
Diego Ferney Castañeda Muñoz Magister in
materials science 80 Formatted: Centered
Total cost for personnel
Material
Devices, equipment, extension to existing equipment, etc. Year1 Year2 Total
Total cost for material
Supplies
Itemize below Year1 Year2 Total
Total cost for supplies
Rental of equipment
Total cost for rental equipment
18
Project related travel
Total cost for travel
Other project related costs

Total for project related costs
Conferences
Total costs for conferences
Total costs
Year1 Year2 Total
Total costs
19
Part 6: Existing resources
Personnel
Name, First name and role in the study Percentage of project
participation
DME3D Medellin-Colombia Sudamerica- auspice implants of materials
At the moment there is a company that does not give the implants. Formatted: English (United States)
Equipment
Describe below
Infrastructure
Describe below
Financial sources
Describe below
Currency and amount Organization
20

AO Start Up Grant Application Form 2015 3

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AO Start Up Grant Application Form 2015 3

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S-15-

AO Start-up Grant Application

Before you submit your grant application

Please check our website

Please check that

Please be reminded that

Please submit your application

You will receive

Part 1: General information

Type of application ☒ New application ☐ Continuation of project no

Total amount requested in Swiss Francs CHF $ 60.000

Keywords Click here to enter text. Click here to enter text.

Click here to enter text.

Position and employment

Other experience and professional membership

Position and employment

Other experience and professional membership

Position and employment

Other experience and professional membership

Position and employment

Other experience and professional membership

Position and employment

Other experience and professional membership

Do not exceed 2500 characters including spaces.

2 Outline the problem

3 State of the art in this field

4 Past research of the applicant in this field

5 Open questions, hypothesis, aim of the project

5.1 Open questions

1. A medical evaluation imagenological

5.3.1 Anticipated results for year 1

5.3.2 Anticipated results for year 2 (if applicable)

6 Detailed research plan

6.1 Study subjects, specimen or materials

6.2 Effect and outcome variables

6.3 Methods for taking measurements

6.5 Estimation of sample size and power

7 Relevance of the project

ACTIVITY 1 2 3 4 5 6 7 8 9 10 11 12 Formatted: Centered

9.1 By the investigators

Click here to enter text.

9.2 By other authors

Formatted: Spanish (Colombia)

Formatted: Indent: Left: 0", Hanging: 0.25", No bullets or

Formatted: English (United States)

Is this application currently being submitted elsewhere?

If yes, to which organizations, and by what date is a decision expected?

Click here to enter text.

Submitted to Amount requested Decision expected

Submitted to Decision Amount requested Amount approved

Please note that the amounts must be converted to Swiss Francs.

Total cost for personnel

Total cost for material

Total cost for supplies

Total cost for rental equipment

Total cost for travel

Other project related costs

Total for project related costs

Total costs for conferences

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