Professional Documents
Culture Documents
eCollection 2018.
Rabani S(1), Sardarinia M(1), Akbarpour S(1)(2), Azizi F(3), Khalili D(1),
Hadaegh F(1).
Author information:
among a Middle Eastern population with prevalent CVD during a median follow up of
12 years.
METHODS: Patients with prevalent CVD (n = 282, men = 167), with a mean age of
60.76 years were evaluated in four study phases of the TLGS (Tehran lipid glucose
RESULT: The adjusted prevalence of general and central adiposity, diabetes and
physical inactivity at baseline was 25.18, 60.14, 25.03 and 43.74%, respectively
and had increasing trends during the study period, reaching 41.32, 66.74, 43.20
and 50.32%, respectively, at the last visit. Although systolic, but not diastolic
non-HDL-C at baseline was 74.54, 59.89 and 96.53%, respectively, and showed
improved trends reaching 44.87, 47.12 and 96.06% respectively; however, the
favorable trend was not observed for high low density cholesterol. Significant
and glucose lowering medications, but not for aspirin. The prevalence of current
smoking (11.05 vs 16.83%, p value = 0.042) and chronic kidney disease (44.16 vs
CONCLUSION: Except for lipid profile status, dangerous trends for other CVD risk
factors were demonstrated among CVD patients, which can be a harbinger for high
rates of CVD mortality; these findings highlight the need for urgent
these patients.
DOI: 10.1371/journal.pone.0195543
PMCID: PMC5955533
2017 Jul 1.
Model.
Author information:
100053, China.
in vivo. Previous studies have reported that E2 could promote insulin secretion
and protect β cells from apoptosis. In this study, the partial pancreatectomy
(PPx) model was used to study the role of E2 in islet cell proliferation. The
animals were divided into four groups, including sham control, PPx model, E2, and
PPx, and the protein expression of forkhead transcription factor M1, cyclin A2,
cyclin B1, and cyclin E2 also significantly increased in the isolated islets. The
group. Additionally, the effects of E2 on the PPx mice were partially blocked by
promoted islet cell proliferation in PPx model mice, and it upregulated the
mice may be an attractive model for the study of islet cell proliferation.
DOI: 10.1210/js.2016-1073
PMCID: PMC5686603
PMID: 29264547
W(7)(8)(9)(10).
Author information:
Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, China.
Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, China.
wpjia@sjtu.edu.cn.
wpjia@sjtu.edu.cn.
assess the associations between different adipose distributions and the risk of
METHODS: The Shanghai Nicheng Cohort Study was conducted among Chinese adults
aged 45-70 years. The baseline data of 12,137 participants were analyzed.
Subcutaneous and visceral fat area (SFA and VFA) were measured by magnetic
tolerance test.
RESULTS: The multivariable-adjusted odds ratios (OR) and 95% confidence intervals
(CI) of newly diagnosed diabetes per 1-standard deviation increase in SFA and VFA
were 1.29 (1.19-1.39) and 1.61 (1.49-1.74) in men, and 1.10 (1.03-1.18) and 1.56
newly diagnosed diabetes disappeared in men and was reversed in women (OR 0.86
[95% CI, 0.78-0.94]) after additional adjustment for body mass index (BMI) and
VFA. The positive association between VFA and newly diagnosed diabetes remained
significant in both sexes after further adjustment for BMI and SFA. Areas under
by VFA (0.679 [95% CI, 0.659-0.699] for men and 0.707 [95% CI, 0.690-0.723] for
CONCLUSIONS: SFA was beneficial for lower risk of newly diagnosed diabetes in
women but was not associated with newly diagnosed diabetes in men after taking
general obesity and visceral obesity into account. VFA, however, was associated
with likelihood of newly diagnosed diabetes in both Chinese men and women.
DOI: 10.1186/s12933-018-0734-8
PMCID: PMC6020307
PMID: 29945626
Gale R(1)(2), Scanlon PH(1)(3), Evans M(1)(4), Ghanchi F(1)(5), Yang Y(1)(6),
Author information:
Cardiff, UK.
This paper identifies best practice recommendations for managing diabetes and
due to diabetic eye disease. In people with diabetes, early optimal glycaemic
complications. The authors propose more can and should be done to maximise
and health behaviours towards the management of their own diabetes. Awareness of
diabetic macular oedema remains low among people with diabetes, who need access
to education early in their disease about how to manage their diabetes to delay
The recommendations are based on round table presentations and discussions held
DOI: 10.1038/eye.2017.53
PMCID: PMC5437340
Author information:
The aim of this study was to estimate the incidence of T2DM in three population
groups: rural, rural-to-urban migrants and urban dwellers. Data from the PERU
MIGRANT Study was analysed. The baseline assessment was conducted in 2007-2008
2015-16. T2DM was defined based on fasting glucose and self-reported diagnosis.
Poisson regression models and robust variance to account for cluster effects were
used for reporting risk ratios (RR) and 95%CI. At baseline, T2DM prevalence was
7.7 (SD: 1.1) years, 6,076 person-years of follow-up, 61 new cases were
identified. The incidence rates in the urban, migrant and rural groups were 1.6,
0.9 and 0.5 per 100 person-years, respectively. Relative to rural dwellers, a
4.3-fold higher risk (95%CI: 1.6-11.9) for developing T2DM was found in urban
dwellers and 2.7-fold higher (95%CI: 1.1-6.8) in migrants with ≥30 years of urban
exposure. Migration and urban exposure were found as significant risk factors for
DOI: 10.1038/s41598-018-23812-6
PMCID: PMC5883030
PMID: 29615740
adults.
Lv J(1)(2), Yu C(1), Guo Y(3), Bian Z(3), Yang L(4), Chen Y(4), Hu X(5), Hou
W(6), Chen J(7), Chen Z(4), Qi L(8)(9), Li L(1)(3); China Kadoorie Biobank
Collaborative Group.
Author information:
(4)Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield
(5)Hainan Center for Disease Control & Prevention, Haikou, Hainan, China.
(6)Licang Center for Disease Control & Prevention, Qingdao, Shandong, China.
(7)China National Center for Food Safety Risk Assessment, Beijing, China.
Methods: We examined the associations of six lifestyle factors with T2DM in the
China Kadoorie Biobank of 461 211 participants aged 30-79 years without diabetes,
factors as non-smoking or having stopped for reasons other than illness; alcohol
consumption of <30 g/day; upper quarter of the physical activity level; diet rich
in vegetables and fruits, low in red meat and with some degree of replacement of
rice with wheat; body mass index (BMI) of 18.5-23.9 kg/m2; and waist-to-hip ratio
low-risk factors, the hazard ratio [95% confidence interval (CI)] for those with
at least three low-risk factors was 0.20 (0.19, 0.22). Approximately 72.6%
BMI, WHR, diet and physical activity. The population attributable risk percentage
(PAR%) of diabetes appeared to be similar for men and women, and higher among
DOI: 10.1093/ije/dyx074
PMCID: PMC5837408
risk assessment.
Author information:
Health, National Taiwan University, 17 Xuzhou Rd, Rm 706, Taipei, 10055, Taiwan.
Sheffield, UK.
Taiwan.
Taipei, Taiwan.
Health, National Taiwan University, 17 Xuzhou Rd, Rm 706, Taipei, 10055, Taiwan.
hsienho@gmail.com.
the best available information to estimate the adult mortality (>30 years) burden
factors in Taiwan.
health surveys, cause-specific mortality from the National Death Registry, and
RESULTS: In 2009, high blood glucose accounted for 14,900 deaths (95% UI:
smoking (13,340 deaths, 95% UI: 10,330-16,450), high blood pressure (11,190
deaths, 95% UI: 7,370-9,840), and dietary risks (high sodium intake and low
cardiometabolic risk factors of high blood pressure, high blood glucose, high
cholesterol, and overweight-obesity jointly accounted for 12,120 deaths (95% UI:
infections from hepatitis B virus (HBV) and hepatitis C virus (HCV) were
responsible for 6,300 deaths (95% UI: 5,610-6,980) and 3,170 deaths (95% UI:
1,860-4,490), respectively, and betel nut use was associated with 1,780 deaths
from oral, laryngeal, and esophageal cancer (95% UI: 1,190-2,360). The leading
risk factors for years of life lost were similar, but the impact of tobacco
smoking and alcohol use became larger because the attributable deaths from these
risk factors occurred among young adults aged less than 60 years.
CONCLUSIONS: High blood glucose, tobacco smoking, and high blood pressure are the
major risk factors for deaths from diseases and injuries among Taiwanese adults.
A large number of years of life would be gained if the 13 modifiable risk factors
DOI: 10.1186/s12963-017-0134-4
PMCID: PMC5415794
2018.
Advanced Glycation End Products Increase MDM2 Expression via Transcription Factor
KLF5.
Author information:
(1)School of Life Sciences, Shanxi University, Taiyuan, Shanxi 030006, China.
Type 2 diabetes increases the risk for all-site cancers including colon cancer.
increased level of advanced glycation end products (AGEs), which comes from a
diabetes promoted MDM2 expression in colon cells and the underlying mechanisms.
Our results showed that AGE increased the protein level of MDM2 in a cell model
and promoted binding between MDM2 and Rb as well as p53, which led to degradation
of Rb and p53. KLF5 was able to bind to the regulatory sequence of the MDM2 gene,
and knockdown of the KLF5 protein level inhibited the AGE-triggered MDM2
overexpression, which indicated that KLF5 was the transcription factor for MDM2.
In a mouse model of diabetes, we found that AGE level was increased in serum. The
protein levels of both KLF5 and MDM2 were increased. KLF5 was able to bind to the
regulatory sequence of the MDM2 gene. In conclusion, our results suggest that
diabetes increases the level of AGE which enhances the expression of MDM2 via
DOI: 10.1155/2018/3274084
PMCID: PMC6151196
PMID: 30271790
Adverse effect of long work hours on incident diabetes in 7065 Ontario workers
Author information:
Canada.
Canada.
risk factors of diabetes. In this regard, long work hours have recently been
linked with diabetes, but more high-quality prospective studies are needed. We
evaluated the relationship between long work hours and the incidence of diabetes
Research design and methods: Data from Ontario respondents (35-74 years of age)
to the 2003 Canadian Community Health Survey were prospectively linked to the
Ontario Health Insurance Plan database for physician services and the Canadian
then performed to evaluate the relationship between long work hours (≥45 hours
Results: Long work hours did not increase the risk of developing diabetes among
men. However, among women, those usually working 45 hours or more per week had a
significantly higher risk of diabetes than women working between 35 and 40 hours
per week (HR: 1.63 (95% CI 1.04 to 2.57)). The effect was slightly attenuated
when adjusted for the potentially mediating factors which are smoking, leisure
Conclusion: Working 45 hours or more per week was associated with an increased
incidence of diabetes among women, but not men. Identifying modifiable risk
DOI: 10.1136/bmjdrc-2017-000496
PMCID: PMC6038836
PMID: 30002856
10. J Hosp Manag Health Policy. 2018 Apr;2. pii: 17. doi: 10.21037/jhmhp.2018.04.07.
The affordable care act and insurance coverage for persons with diabetes in the
United States.
Brown DS(1), Delavar A(1).
Author information:
(1)Brown School, Washington University in St. Louis, St. Louis, MO, USA.
Comment on
DOI: 10.21037/jhmhp.2018.04.07
PMCID: PMC6117109
PMID: 30175323
Author information:
(1)Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA.
myra.popejoy@merck.com.
(2)Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA.
susceptibility to bacterial infections and poor treatment outcomes. This post hoc
approved for the treatment of cIAI (with metronidazole) and cUTI (including
pyelonephritis).
METHODS: Patients from the phase 3 ASPECT studies with (n = 245) and without
RESULTS: Significantly more patients with than without diabetes were 65 years of
age or older; patients with diabetes were also more likely to weigh ≥75 kg at
APACHE II scores ≥10 (33.8% vs 17.0%). More patients with diabetes had
cUTI. Clinical cIAI and composite cure cUTI rates across study treatments were
lower in patients with than without diabetes (cIAI, 75.4% vs 86.1%, P = 0.0196;
cUTI, 62.4% vs 74.7%, P = 0.1299) but were generally similar between the
CONCLUSIONS: In this post hoc analysis, patients with diabetes in general were
with diabetes had lower cure rates and a significantly higher frequency of
adverse events than patients without diabetes, likely because of the higher rates
population.
DOI: 10.1186/s12879-017-2414-9
PMCID: PMC5414364
eCollection 2018.
Tsai T(1), Kuehn S(1), Tsiampalis N(1), Vu MK(1), Kakkassery V(1), Stute G(1),
Author information:
Bochum, Germany.
Therefore, vitreous samples were obtained from patients with DR and patients with
pleiotropic cytokines (IL-2, IL-4, IL-13) as well as VEGF, VEGF-A, and PGF were
measured using an enzyme linked immunosorbent assay (ELISA). IL-1ß (p = 0.02) and
elevated in the DR patients, while IL-6 (p = 0.51) level was comparable in both
DOI: 10.1371/journal.pone.0194603
PMCID: PMC5870958
Scoparia dulcis.
Author information:
Lanka.
Erratum in
treatment for jaundice, stomach problems, skin disease, fever, and kidney stones,
reproductory issues, and piles. Evidence has been demonstrated through scientific
activity of the plant and its bioactive constituents are through α-glucosidase
some of the compounds which have been identified as responsible for these
pharmacological aspects are carried out through either in vivo or clinical means.
DOI: 10.1155/2016/8243215
PMCID: PMC4995349
PMID: 27594892
Aug 16.
Application of the integrated glucose-insulin model for cross-study
Author information:
following various glucose challenge settings. The aim of the present work was to
METHODS: Data from four clinical studies were pooled, including glucose and
metformin alone following mixed-meal tolerance tests. The data were collected
from a wide range of patients with respect to the duration of diabetes and level
of glycaemic control.
RESULTS: The IGI model was expanded by four patient-specific covariates. The
glucose clearance and the magnitude of the incretin effect, while baseline body
addition, glucose dose was found to have an impact on glucose absorption rate.
The developed model was used to simulate glucose and insulin profiles in
challenge.
between T2DM patients across a wide range of glycaemic control. The addition of
patient-specific covariates in the IGI model might be valuable for the future
clinical studies.
DOI: 10.1111/bcp.13069
PMCID: PMC5099540
eCollection 2017.
Takahashi H(1), Tampo H(1), Arai Y(1), Inoue Y(1), Kawashima H(1).
Author information:
staging using a wide area is more desirable than that using a limited area. We
2,740 patients with diabetes. Nonmydriatic 45° field color fundus photographs
were taken of four fields in each eye annually at Jichi Medical University
between May 2011 and June 2015. A modified fully randomly initialized GoogLeNet
deep learning neural network was trained on 95% of the photographs using manual
of the 9,939 posterior pole fundus photographs using real prognoses. In addition,
95% of the photographs were learned by the modified GoogLeNet. Main outcome
RESULTS: The PABAK to modified Davis grading was 0.64 (accuracy, 81%; correct
answer in 402 of 496 photographs). The PABAK to real prognosis grading was 0.37
(accuracy, 96%).
DOI: 10.1371/journal.pone.0179790
PMCID: PMC5480986
Lim LL(1)(2)(3), Lau ESH(1)(2), Kong APS(1)(2)(4), Davies MJ(5), Levitt NS(6),
McGill M(11), Ogle GD(12), Orchard TJ(13), Clarke P(14), Holman RR(15), Gregg
EW(16), Gagliardino JJ(17), Chan JCN(18)(2)(4).
Author information:
Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China.
(2)Asia Diabetes Foundation, Prince of Wales Hospital, Shatin, Hong Kong Special
(4)Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong
Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region,
China.
Australia.
Australia.
Melbourne, Australia.
Atlanta, GA.
Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China
jchan@cuhk.edu.hk.
OBJECTIVE: The implementation of the Chronic Care Model (CCM) improves health
RESEARCH DESIGN AND METHODS: We searched PubMed and Ovid MEDLINE (January
more quality improvement strategies from two or more domains (health system,
health care providers, or patients) lasting ≥12 months with one or more clinical
outcomes. Two reviewers extracted data and appraised the reporting quality.
revealed pooled mean differences in HbA1c of -0.28% (95% CI -0.35 to -0.21) (-3.1
mmol/mol [-3.9 to -2.3]), in systolic blood pressure (SBP) of -2.3 mmHg (-3.1 to
-1.4), in diastolic blood pressure (DBP) of -1.1 mmHg (-1.5 to -0.6), and in LDL
patients with LDL-C ≥3.4 mmol/L (-0.31 vs. -0.10 mmol/L for <3.4 mmol/L;
Pdifference = 0.013), studies from Asia (HbA1c -0.51% vs. -0.23% for North
America [-5.5 vs. -2.5 mmol/mol]; Pdifference = 0.046), and studies lasting >12
months (SBP -3.4 vs. -1.4 mmHg, Pdifference = 0.034; DBP -1.7 vs. -0.7 mmHg,
Pdifference = 0.047; LDL-C -0.21 vs. -0.07 mmol/L for 12-month studies,
Pdifference = 0.049). Patients with median age <60 years had greater HbA1c
reduction (-0.35% vs. -0.18% for ≥60 years [-3.8 vs. -2.0 mmol/mol]; Pdifference
mmol/mol]).
CONCLUSIONS: Despite the small effect size of multicomponent integrated care (in
part attenuated by good background care), team-based care with better information
DOI: 10.2337/dc17-2010
eCollection 2018.
Ong SE(1), Koh JJK(1), Toh SES(2)(3), Chia KS(1), Balabanova D(4), McKee M(4),
Author information:
Singapore, Singapore.
Singapore.
METHODS AND FINDINGS: A protocol for this study was published on the PROSPERO
IMEMR, and WPRIM. There were no restrictions on date, language, or study designs.
Two reviewers independently screened studies for eligibility, extracted the data,
synthesis; 7 were conducted in LMICs. Through this review, we found two key
constraints faced by the patient and limited access to health services and
medication. We also found three health system factors that facilitate effective
T2DM care and management: the use of innovative care models, increased pharmacist
professionals.
pharmacists. More studies which identify the effect of health system arrangements
PMCID: PMC5875848
eCollection 2016.
N(1)(2)(3)(4).
Author information:
Depression and diabetes are independent risk factors for one another, and both
are associated with increased risk of cognitive decline. Diabetes patients with
lower cognitive function are more likely to suffer poorer health outcomes.
However, the role of depression in cognitive decline among people with diabetes
is not well understood. This systematic review assessed whether adults with
decline relative to individuals with diabetes alone. Searches were run in CINAHL,
the Cochrane Central Register of Controlled Trials, EMBASE, PsycINFO, and PubMed
used for quality assessment of each study and its collected outcome. Fifteen
articles were included in the final analysis. The high degree of heterogeneity in
any of the studies, and the risk of bias observed in these studies limits the
strength of the evidence. Nonetheless, this review found the presence of comorbid
depression was associated with poorer cognitive outcomes than for persons with
diabetes alone. While large-scale preventive efforts must address epidemic levels
must be cognizant of the added difficulties that depression poses to patients and
the extra support required to management diabetes in these cases. This systematic
review is registered with the University of York Centre for Reviews and
DOI: 10.1371/journal.pone.0160809
PMCID: PMC4985066
19. Liver Int. 2017 Feb;37(2):251-258. doi: 10.1111/liv.13241. Epub 2016 Sep 16.
Goh GB(1)(2), Pan A(3)(4), Chow WC(1)(2), Yuan JM(5)(6), Koh WP(2)(7).
Author information:
Singapore, Singapore.
(2)Duke-NUS Medical School, Singapore, Singapore.
China.
(4)Key Laboratory of Environment and Health, Ministry of Education, and State Key
China.
Singapore, Singapore.
Comment in
METHODS: We used data collected and analysed from the Singapore Chinese Health
during enrolment between 1993 and 1998. Information on diet, lifestyle and
medical history was collected via structured questionnaire. Mortality cases from
cirrhosis in the cohort were identified via linkage with nationwide death
RESULTS: After a mean follow-up of 16.9 years, there were 133 deaths from
cirrhosis. Diabetes was associated with an increased risk of cirrhosis mortality
(hazard ratio [HR]: 2.80; 95% confidence interval [CI]: 2.04-3.83), and for both
viral (HR: 2.20; 95% CI: 1.18-4.11) and non-viral hepatitis-related cirrhosis
mortality (HR: 3.06; 95% CI: 2.13-4.41). The association between diabetes and
of body mass index (BMI) less than 23 kg/m2 (HR: 7.11; 95% CI: 3.42-14.79)
=0.02).
normal in Asia.
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
DOI: 10.1111/liv.13241
PMCID: PMC5225025
T(5).
Author information:
Thailand.
and DM have mostly been conducted in specific areas with rather small sample
sizes or not with nationally representative samples. Their results have also been
MATERIALS AND METHODS: This study utilized the data from the National
Statistical Office (NSO) in 2010 and 2012. A total of 17,045 and 16,903
participants respectively who met the inclusion criteria were included in this
RESULTS: The prevalence of DM was 3.70% (95% CI: 3.36 to 4.05) and 8.11% (95%CI:
6.25 to 9.74) in 2010 and 2012 respectively and the prevalence of DM in 2012 was
1.36 times (95% CI: 1.25 to 1.48) when compared with 2010. The multilevel
significantly higher among those who aged 55-64 years old in 2010 and 65 years
old or greater in 2012 (ORadj = 18.13; 95%CI: 9.11 to 36.08, ORadj 31.69; 95%CI:
20.78 to 48.33, respectively), females (ORadj = 2.09; 95%CI: 1.66 to 2.62, ORadj
= 1.77; 95%CI: 1.54 to 2.05, respectively), and had lower education attainment
(ORadj = 5.87; 95%CI: 4.70 to 7.33, ORadj= 1.22; 95%CI: 1.04 to 1.45,
CONCLUSION: The study indicated that SES has been associated with DM. Those with
female gender, old age and low educational attainment were vulnerable to DM.
DOI: 10.7860/JCDR/2017/28221.10286
PMCID: PMC5583803
PMID: 28892937
Seo YG(1), Choi HC(2), An AR(3), Park DJ(4), Park YJ(4), Lee KE(5), Park
Author information:
(3)Department of Family Medicine, Center for Health Promotion and Optimal Aging,
Health Promotion Center for Cancer Survivor, Seoul National University Hospital,
METHODS: A case-control study was performed. A total of 415 healthy controls with
thyroid ultrasound screening and physician consultation were selected from the
Thyroid Cancer Longitudinal Study (T-CALOS). Among patients with thyroid cancer
who were enrolled in T-CALOS, 415 patients were matched to the control group
according to age and sex. We assessed the effects of T2DM, T2DM duration, and
RESULTS: Women with T2DM had lower odds of thyroid cancer than women without T2DM
(odds ratio [OR]: 0.40, 95% confidence interval [CI]: 0.20-0.81). Individuals
receiving T2DM medication had higher odds of thyroid cancer compared to those
without T2DM medication (OR: 5.21, 95% CI: 1.58-17.15). Individuals with T2DM
duration <6 years had lower odds of thyroid cancer compared to those without T2DM
CONCLUSIONS: Individuals with early T2DM are presumed to have a low incidence of
thyroid cancer, and this effect seems to last up to 6 years after diagnosis of
T2DM.
DOI: 10.1155/2017/5850879
PMCID: PMC5523441
Author information:
Madrid, Spain.
Madrid, Spain.
(8)Primary Care Research Unit, Primary Care Management. Madrid Health Service,
Madrid, Spain.
(9)Area of Preventive Medicine and Public Health, Rey Juan Carlos University,
Madrid, Spain.
of Madrid (Spain).
index of seven indicators from four domains of education, wealth, occupation and
living conditions.
RESULTS: In regression analyses adjusted by age and sex and compared with
individuals living in low NSES neighbourhoods, men living in medium and high NSES
neighbourhoods had 10% (95% CI: 6% to 15%) and 29% (95% CI: 25% to 32%) lower
prevalence of diabetes, while women had 27% (95% CI: 23% to 30%) and 50% (95% CI:
47% to 52%) lower prevalence of diabetes. Moreover, the hazard of diabetes in men
living in medium and high NSES neighbourhoods was 13% (95% CI: 1% to 23%) and 20%
(95% CI: 9% to 29%) lower, while the hazard of diabetes in women living in medium
and high NSES neighbourhoods was 17% (95% CI: 3% to 29%) and 31% (95% CI: 20% to
41%) lower. Individuals living in medium and high SES neighbourhoods had 8% (95%
CI: 2% to 15%) and 15% (95% CI: 9% to 21%) lower prevalence of lack of diabetes
control, and a decrease in average HbA1c % of 0.05 (95% CI: 0.01 to 0.10) and
inequity.
DOI: 10.1136/bmjopen-2017-021143
PMCID: PMC6173235
PMID: 30287604
Cohorts.
Lin HH(1), Wu CY(1), Wang CH(1), Fu H(1)(2), Lönnroth K(3), Chang YC(4)(5), Huang
YT(6).
Author information:
Taipei, Taiwan.
Kingdom.
University.
Background: Mounting data have revealed that body mass index (BMI) is inversely
participants. The main exposure was BMI and diabetes ascertained at baseline.
tuberculosis.
(>30 kg/m2) had a 67% (95% confidence interval [CI], -3% to -90%) and 64%
diabetes (0.8% and 2.7% increased odds in the 2 cohorts, respectively) but had a
strongly protective effect not mediated through diabetes (72% and 67% decreased
odds, respectively). Individuals who were simultaneously obese and diabetic had a
individuals.
© The Author 2017. Published by Oxford University Press for the Infectious
DOI: 10.1093/cid/cix852
PMCID: PMC5850624
PMID: 29029077
Faka A(1), Chalkias C(1), Montano D(2), Georgousopoulou EN(3), Tripitsidis A(1),
Germany.
OBJECTIVES: The aim of this study was to investigate the spatial variation of
METHODS: A sample of 2,445 individuals from the greater area of Athens was
randomly enrolled in the ATTICA study between 2001 and 2002. Diabetes was defined
analyses were applied to examine the relationship between diabetes prevalence and
proportions of people with diabetes were found in the West sector and in one
district of the East and South sector each. Regression analysis revealed that the
DOI: 10.1900/RDS.2017.14.381
PMID: 29590231
Associations between body mass index and the risk of renal events in patients
Mohammedi K(1)(2)(3), Chalmers J(4), Herrington W(5), Li Q(1), Mancia G(6), Marre
M(2)(3)(7), Poulter N(8), Rodgers A(1), Williams B(9), Perkovic V(1), Coresh
Author information:
Australia.
Australia. chalmers@georgeinstitute.org.au.
Italy.
(7)Sorbonne Paris Cité, UFR de Médecine, University Paris Diderot, Paris, France.
(8)The International Centre for Circulatory Health, National Heart and Lung
(11)The George Institute for Global Health, University of Oxford, Oxford, UK.
risk of renal disease in patients with type 2 diabetes in the Action in Diabetes
underweight were excluded. The composite outcome "major renal event" was defined
RESULTS: During 5-years of follow-up, major renal events occurred in 487 (4.6%)
patients. The risk increased with higher BMI. Multivariable-adjusted HRs (95%
CIs), compared to normal weight, were: 0.91 (0.72-1.15) for overweight; 1.03
(0.77-1.37) for obesity grade 1; 1.42 (0.98-2.07) for grade 2; and 2.16
(1.34-3.48) for grade 3 (p for trend = 0.006). These findings were similar across
25 kg/m2 increased the risk of major renal events by 4 (1-6)%. Comparable results
patients with type 2 diabetes. Our findings encourage weight loss to improve
PMCID: PMC5851426
PMID: 29343817
eCollection 2017.
Li X(1), Zhao Y(1), Jin Y(2), Zhang T(1), Chang X(1), Liao S(3), Xu H(1), Liu
Author information:
China.
(2)Ningxia Center for Disease Control and Prevention, Yinchuan, Ningxia Hui
(3)Sichuan Provincial Center for Disease Control and Prevention, Chengdu, Sichuan
Although experimental studies have shown that adiponectin and leptin modulate
the associations of serum adiponectin and leptin with β-cell function and insulin
of 783 rural residents, aged 25-74 years, recruited in Ningxia, China was
conducted during 2008-2012. β-cell function and insulin resistance were estimated
using the Homeostasis Model Assessment. Serum adiponectin and leptin were
measured with ELISA. Serum adiponectin concentrations (mean ± SD) were highest in
those with impaired fasting glucose (25.92 ± 34.48 μg/ml), and lowest in those
was found for β-cell function, whereas opposite results were observed for insulin
with β-cell function (%β) [β (95% CI): -7.57 (-12.33, -2.81)] and insulin
association also existed between serum leptin and β-cell function, but serum
leptin was not significantly associated with insulin resistance. The present
study suggests that adiponectin and leptin play a role in the development of
DOI: 10.1371/journal.pone.0182273
PMCID: PMC5546634
Bakrania K(1), Edwardson CL(2), Khunti K(3), Henson J(2), Stamatakis E(4), Hamer
LE5 4PW, United Kingdom; National Institute for Health Research (NIHR)
Leicestershire, LE5 4PW, United Kingdom; National Institute for Health Research
(NIHR) Collaboration for Leadership in Applied Health Research and Care - East
Leicestershire, LE5 4PW, United Kingdom; National Institute for Health Research
Leicestershire, LE5 4PW, United Kingdom; National Institute for Health Research
(NIHR) Collaboration for Leadership in Applied Health Research and Care - East
Health, Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia;
high risk of T2DM, consented to be followed up for mortality. MVPA and sedentary
the independent associations of MVPA and sedentary time with all-cause mortality.
683 participants (250 females (36.6%)) were included and during a mean follow-up
period of 5.7 years, 26 deaths were registered. Every 10% increase in MVPA
time/day was associated with a 5% lower risk of all-cause mortality [Hazard Ratio
(HR): 0.95 (95% Confidence Interval (95% CI): 0.91, 0.98); p = 0.004]; indicating
that for the average adult in this cohort undertaking approximately 27.5 minutes
of MVPA/day, this benefit would be associated with only 2.75 additional minutes
mortality [HR (every 10-minute increase in sedentary time/day): 0.99 (95% CI:
0.95, 1.03); p = 0.589]. These data support the importance of MVPA in adults at
high risk of T2DM. The association between sedentary time and mortality in this
DOI: 10.1016/j.pmedr.2017.01.013
PMCID: PMC5279862
PMID: 28149710
Yamamoto S(1), Kuramoto K(2), Wang N(3), Situ X(2), Priyadarshini M(4), Zhang
Author information:
60612, USA.
congcong.he@northwestern.edu.
Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.
DOI: 10.1016/j.celrep.2018.05.032
PMCID: PMC6054876
PMID: 29898399
Awareness and practices regarding eye diseases among patients with diabetes: a
Konstantinidis L(1), Carron T(2), de Ancos E(3), Chinet L(4), Hagon-Traub I(4),
lazaros.konstantinidis@fa2.ch.
(4)Public Health Service, Department of Health and Social Action, Canton of Vaud,
Lausanne, Switzerland.
study was to evaluate prevalence, awareness and practices regarding eye diseases
RESULTS: While diabetic retinopathy was reported by 40.9% of patients with type 1
diabetes and 9.8% of patients with type 2 diabetes, 35.8% and 12.6% of all
diabetes could damage the eyes was reported by almost all participants; the
majority was also aware of the importance of glycemic control and regular eye
significant proportion of patients with diabetes did not report annual eye
examination. Both healthcare strategic efforts targeting the promotion of regular
(retrospectively registered).
DOI: 10.1186/s12902-017-0206-2
PMCID: PMC5590154
Awareness of Gestational Diabetes and its Risk Factors among Pregnant Women in
Samoa.
Author information:
The risk of developing type 2 diabetes mellitus (T2DM) is greater in mothers with
GDM compared to the general population. Preventing the development of GDM could
help lower the prevalence of T2DM and long-term morbidity in children of affected
mothers. The purpose of this study was to investigate the awareness of GDM and
its risk factors among pregnant women in Samoa, exploring where participants
obtained information, and understanding their attitudes towards diet and physical
Fifty-eight percent women were aware diabetes can occur for the first time during
pregnancy. The greatest information source was from doctors (37%, n=44) followed
by family members (22%, n=28), based on 118 respondents. Only one woman correctly
identified all four risk factors for GDM. Most women recognized eating a healthy
changes to help prevent GDM. These findings suggest awareness of GDM among
pregnant women in Samoa is mixed, with a very small proportion having good
increased education about GDM is necessary, both in hospital clinics and within
PMCID: PMC5304428
31. Braz J Med Biol Res. 2018;51(6):e7238. doi: 10.1590/1414-431x20187238. Epub 2018
Apr 19.
Author information:
principal fractions, which were used to assess the effect on glycemia, liver and
pancreatic architecture, and PPARγ and GLUT4 expression. Normal mice and
fat, and the acute hypoglycemic effect was evaluated. A subacute study involving
daily administration of these fractions to diabetic mice was also performed over
30 days, after which the liver and pancreas were processed by conventional
morphological changes. The most active fraction, the fat fraction, was analyzed
expressions were determined in 3T3-L1 adipocytes. The protein and fat fractions
exhibited hypoglycemic effects in the acute as well as in the 30-day study. Only
the fat fraction led to elevated insulin levels and reduced glycemia, as well as
lower intake of water and food. In the liver, we observed recovery of close
hepatic cords in the central lobule vein following treatment with the fat
fraction, while in the pancreas there was an increased density and percentage of
islets and number of cells per islet, suggesting cellular regeneration. The GC-MS
analysis of fat revealed three fatty acids as the major components. Finally,
DOI: 10.1590/1414-431x20187238
PMCID: PMC5996452
Before the beginning: nutrition and lifestyle in the preconception period and its
Stephenson J(1), Heslehurst N(2), Hall J(3), Schoenaker DAJM(4), Hutchinson J(5),
Cade JE(5), Poston L(6), Barrett G(3), Crozier SR(7), Barker M(8), Kumaran K(9),
Author information:
UK.
(10)Diabetes Unit, King Edward Memorial Hospital and Research Centre, Pune,
Maharashtra, India.
Erratum in
Comment in
present new data from low-income, middle-income, and high-income countries on the
timing and importance of preconception health for subsequent maternal and child
strong links between health before pregnancy and maternal and child health
outcomes, with consequences that can extend across generations, but awareness of
these links is not widespread. Poor nutrition and obesity are rife among women of
have become less distinct, with typical diets falling far short of nutritional
are disappointing. Other interventions to improve diet during pregnancy have had
interventions have been made for preconception diet and lifestyle. Improvements
planning and suggest that it is more common than previously recognised. Planning
for pregnancy is associated with a mixed pattern of health behaviours before
DOI: 10.1016/S0140-6736(18)30311-8
PMCID: PMC6075697
2017.
Rats.
Gong J(1), Hu M(1), Huang Z(2), Fang K(1), Wang D(2), Chen Q(3), Li J(2), Yang
Author information:
Wuhan, China.
Wuhan, China.
explored whether the anti-diabetic effect of BBR was related to the intestine
mucosal barrier. Methods and Results: The rat model of T2DM was established by
high glucose and fat diet feeding and intravenous injection of streptozocin.
Then, those diabetic rats were treated with BBR at different concentrations for 9
However, the treatment with BBR significantly reversed the above changes in
diabetic rats, presenting as the improvement of the high glucose and triglyceride
levels, the relief of the inflammatory changes of intestinal immune system, and
DOI: 10.3389/fphar.2017.00042
PMCID: PMC5290458
PMID: 28217099
Review.
Alzoubi A(1), Abunaser R(1), Khassawneh A(2), Alfaqih M(3), Khasawneh A(4), Abdo
N(2).
Author information:
mental condition that decreases mental and physical functioning and reduces the
increases the risk of diabetes and interferes with its daily self-management.
Diabetes patients with depression have poor glycemic control, reduced quality of
factors that may account for or modulate the relationship between diabetes and
depression. Therefore, this review aims to highlight the most notable body of
relevant literature in the PubMed database, using the keywords "Diabetes AND
clinical trials with large sample sizes (n≥1,000), randomized clinical trials,
present in this review supports the pressing need for long, outcome-oriented,
of patients with these comorbid conditions will improve their medical outcomes
DOI: 10.4082/kjfm.2018.39.3.137
PMCID: PMC5975983
PMID: 29788701
35. Diabetes Care. 2018 Sep;41(9):1901-1908. doi: 10.2337/dc18-0849. Epub 2018 Jul
12.
Massera D(1), Biggs ML(2), Walker MD(3), Mukamal KJ(4), Ix JH(5), Djousse L(6),
Valderrábano RJ(7), Siscovick DS(8), Tracy RP(9), Xue X(1), Kizer JR(10).
Author information:
(1)Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY.
(3)Columbia University Vagelos College of Physicians and Surgeons, New York, NY.
jorge.kizer@einstein.yu.edu.
RESEARCH DESIGN AND METHODS: The analysis included 1,455 female participants from
the population-based Cardiovascular Health Study (CHS) (mean [SD] age 74.6 [5.0]
years). The cross-sectional association of serum total OC and CTX levels with
insulin resistance (HOMA-IR) was examined using multiple linear regression. The
follow-up glucose measurements, medications, and ICD-9 codes, was examined using
CTX (β = -0.08 per SD; P = 0.051) after full adjustment for demographic,
lifestyle, and clinical covariates. During a median follow-up of 11.5 years, 196
exhibited inverse associations with incident diabetes (OC: hazard ratio 0.85 per
mechanisms linking abnormal bone homeostasis and energy metabolism could uncover
DOI: 10.2337/dc18-0849
Haljas K(1), Amare AT, Alizadeh BZ, Hsu YH, Mosley T, Newman A, Murabito J,
Tiemeier H, Tanaka T, van Duijn C, Ding J, Llewellyn DJ, Bennett DA, Terracciano
A, Launer L, Ladwig KH, Cornelis MC, Teumer A, Grabe H, Kardia SLR, Ware EB,
Author information:
University, Lund, Sweden; Department of General Practice and Primary Health Care
University and National Heart, Lung, and Blood Institute's Framingham Heart
(van Duijn), Erasmus University Medical Center, Rotterdam; Centre for Medical
North Carolina; University of Exeter Medical School (Llewellyn), Exeter, UK; Rush
Germany & German Center for Diabetes Research (DZD), München-Neuherberg, Germany;
if genetic correlation and pleiotropic loci exist between depressive symptoms and
analyzed genetic correlation between depressive symptoms and T2D and glycemic
and 114,981 controls), fasting glucose, fasting insulin, and homeostatic model
RESULTS: The SNP-based heritability ranged from 0.04 to 0.10 in each individual
symptoms and T2D (in the IGF2BP2, CDKAL1, CDKN2B-AS, and PLEKHA1 genes), and
fasting glucose (in the MADD, CDKN2B-AS, PEX16, and MTNR1B genes).
were identified between depressive symptoms, T2D, and fasting glucose, suggesting
PMID: 29280852
Body fatness, diabetes, physical activity and risk of kidney stones: a systematic
Author information:
Imperial College London, St. Mary's Campus, Norfolk Place, Paddington, London, W2
d.aune@imperial.ac.uk.
(4)INSERM (French National Institute for Health and Medical Research), CESP,
Imperial College London, St. Mary's Campus, Norfolk Place, Paddington, London, W2
1PG, UK.
between adiposity, diabetes, and physical activity and the risk of kidney stones.
PubMed and Embase were searched up to April 22nd 2018 for relevant studies.
Summary relative risks (RRs) and 95% confidence intervals (CIs) were calculated
using random effects models. Thirteen cohort studies were included. The summary
relative risk was 1.21 (95% CI 1.12-1.30, I2 = 76%, n = 8) per 5 unit increment
weight and 1.12 (95% CI 1.06-1.18, I2 = 86%, n = 3) per 5 kg of weight gain. The
summary RR was 1.16 (95% CI 1.03-1.31, I2 = 51%, n = 10) for participants with
I2 = 80%, n = 4) for high vs. low physical activity. These results suggest a
positive association between adiposity and diabetes and the risk of kidney
DOI: 10.1007/s10654-018-0426-4
PMCID: PMC6208979
Body mass index trajectory patterns and changes in visceral fat and glucose
Kuwahara K(1)(2), Honda T(3), Nakagawa T(3), Yamamoto S(3), Hayashi T(3), Mizoue
T(1).
Author information:
(1)National Center for Global Health and Medicine, Bureau of International Health
Japan.
non-diabetic Japanese participants (2,789 women) aged 30-64 years were assessed
with a mean follow-up of 7.6 years. Diabetes was diagnosed via fasting glucose,
glucose metabolism were estimated using mixed models. 1,892 individuals developed
47.3% were classified as "medium BMI" (n = 895), and had increased mean BMI
within the obesity category before diagnosis. The "low BMI" group (38.4%,
n = 726) had an initial mean BMI of 21.9 kg/m2, and demonstrated small weight
gain. The "high BMI" group (n = 271) were severely obese and showed greater
increase in BMI until diagnosis. All groups which developed diabetes showed
compensation for insulin resistance. All groups not developing diabetes showed
measured variables were relatively stable during observation. These data suggest
that visceral fat gain may induce β-cell failure in compensation for insulin
DOI: 10.1038/srep43521
PMCID: PMC5339907
Author information:
PMCID: PMC6008335
PMID: 29921872
eCollection 2017.
A camera-phone based study reveals erratic eating pattern and disrupted daily
Author information:
America.
(4)UC San Diego Center for Circadian Biology, San Diego, California, United
States of America.
retrospective analyses of human nutrition data have shown that reduced length of
overnight fasting or increased late night eating increases risk for metabolic
diseases including obesity and diabetes. However, the daily rhythm in eating
information through food diary and food log pay little attention to the timing of
eating which may also change from day to day. We adopted a novel cell-phone based
that eating events are widespread throughout the day, with <30% of calories
consumed before noon and >30% consumed in evening and late night hours. There was
little difference in eating pattern between weekdays and weekends. In this cohort
more than 50% of people spread their caloric intake events over 15 h or longer.
One decile of the cohort who were spouses of shift-workers or had flexible work
schedule spread their caloric intake over 20 h. Although the nutrition quality
and diversity of food consumed is different between South-East Asian and Western
DOI: 10.1371/journal.pone.0172852
PMCID: PMC5338776
41. Biomed Res Int. 2018 Apr 3;2018:8578394. doi: 10.1155/2018/8578394. eCollection
2018.
Author information:
Doha, Qatar.
(2)Adult Cardiology, Heart Hospital, Hamad Medical Corporation, Doha, Qatar.
Bordeaux, France.
DOI: 10.1155/2018/8578394
PMCID: PMC5903188
eCollection 2016.
Cardiovascular Risk Factors of Adults Age 20-49 Years in the United States,
Author information:
(1)Public Health Research, Social & Scientific Systems, Inc., Silver Spring,
BACKGROUND: The health of younger adults in the U.S. has important public health
and economic-related implications. However, previous literature is insufficient
to fully understand how the health of this group has changed over time. This
period. Logistic regression was used to determine the odds [odds ratio (OR), 95%
for age, sex, and race, and fully adjusted models additionally adjusted for
adjusted). There was no difference over time for high cholesterol, but
1988-1994 (OR = 0.80, 0.68-0.94, fully adjusted). The use of hypertensive and
over the past 40 years, but treatment for hypertension and high cholesterol has
improved. The sub-optimal and worsening health in younger adults may have a
substantial impact on health care utilization and costs, and should be considered
PMCID: PMC4995093
Diabetes and Digestive and Kidney Diseases and Social & Scientific Systems, Inc.
does not alter our adherence to the PLOS ONE policies on sharing data and
materials.
43. Front Genet. 2017 Jun 6;8:75. doi: 10.3389/fgene.2017.00075. eCollection 2017.
Vieira A(1), Druelle N(1), Avolio F(1), Napolitano T(1), Navarro-Sanz S(1),
Author information:
alternative therapies has become a crucial research goal. Most current efforts
DOI: 10.3389/fgene.2017.00075
PMCID: PMC5459879
PMID: 28634486
44. BMJ Open Diabetes Res Care. 2017 Jan 23;5(1):e000327. doi:
Fan W(1), Lee DH(1), Billimek J(2), Choi S(3), Wang PH(1).
Author information:
diabetes prevalence and associated risk factors among Asian immigrants in the USA
RESEARCH DESIGN AND METHODS: We examined adults aged 18 and older from the recent
California Health Interview Survey data sets from 2003 to 2013 to determine
From 2003 to 2013, the prevalence of DM and pre-DM combined rose from 6.8% to
12.4% in Asian immigrants and 5.5% to 6.9% in whites. Much of the increase could
be attributed to pre-DM, which rose from 0.7% to 3.2% in Asian immigrants during
the study period. The impacts of age and body mass index on DM risk were
were found less likely to engage in physical activity than were non-DM whites.
After adjustment of various associated factors, Asian immigrants were more likely
than whites to have DM and this relative risk for DM gradually increased across
immigrants in California was observed during the previous decade. To reduce the
specific risk factors for this ethnic group, including encouraging physical
activity.
DOI: 10.1136/bmjdrc-2016-000327
PMCID: PMC5278214
PMID: 28176974
Conflict of interest statement: Conflicts of Interest: None declared.
2017 Nov 7.
Kang T(1), Jensen P(1), Huang H(1), Lund Christensen G(2), Billestrup N(2),
Larsen MR(3).
Author information:
N, Denmark.
balance and glucose homeostasis. However, the molecular mechanisms underlying the
novel signaling pathways involved in the initial release of insulin from PBCs
Langerhans derived from newborn rats with a subsequent 9-10 days of maturation in
vitro were stimulated with 20 mm glucose for 0 min (control), 5 min, 10 min, and
signaling) at 15 min GSIS, which may increase our understanding of the molecular
© 2018 by The American Society for Biochemistry and Molecular Biology, Inc.
DOI: 10.1074/mcp.RA117.000217
PMID: 29113996
Author information:
Marburg, Germany.
lateral flow-based point-of-care rapid test (POCT) for elevated intact proinsulin
challenge or a meal.
METHODS: POCT results were obtained by health care professionals from 60 patients
and healthy subject (33 female, 27 male, 28 type 2 diabetes, age: 53.6 ± 12.3
years). An additional venous blood sample was obtained from all participants for
RESULTS: Elevated intact proinsulin levels (>15 pmol/L) were determined by the
reference method in 26 participants, of whom 22 were also positive with the POCT
(sensitivity: 85%). All 34 subjects with low intact proinsulin levels were tested
proinsulin levels in 85% of the tested subjects and no false positive test result
occurred. This POCT can therefore serve as a simple screening tool for
risk for development of type 2 diabetes and/or macrovascular events within the
DOI: 10.1177/1932296816663745
PMCID: PMC5478019
Ndayisaba A(1), Harerimana E(2), Borg R(1), Miller AC(3), Kirk CM(1), Hann K(4),
Hirschhorn LR(5), Manzi A(6), Ngoga G(1), Dusabeyezu S(1), Mutumbira C(2), Mpunga
T(2), Ngamije P(2), Nkikabahizi F(2), Mubiligi J(1), Niyonsenga SP(2), Bavuma
Author information:
improvement program that connected nurse mentors with nurse mentees to support
Methods: This is a descriptive study. Routinely collected data from patients with
type 2 diabetes cared for at rural health center NCD clinics between January 1,
2013 and December 31, 2015, were extracted from EMR system. Data collected as
Results: The patient population reflects the rural settings, with low rates of
traditional NCD risk factors: 5.6% of patients were current smokers, 11.0% were
current consumers of alcohol, and 11.9% were obese. Of 263 observed nurse
time. Similarly, agreement levels were high for medication, laboratory exam, and
DOI: 10.1155/2017/2657820
PMCID: PMC5738565
diabetic rats.
Earlier studies indicated that aqueous extract of turnip leaf (AETL) has
Methods: Metformin at the two different doses (50,100 mg/kg) and AETL at the dose
(FBG) was measured at the times 0, 7, 14, 21 and 28 days after investigation. At
the end of study, liver enzymes activity [aspartate aminotransferase (AST) and
Results: Both treatments could significantly decrease FBG levels when they
metformin. While neither metformin nor AETL could ameliorate liver alterations
metformin with AETL enhance the prior effectiveness and reduced the latter
PMCID: PMC5756016
PMID: 29322007
markers.
Author information:
outcome for pancreas has not been adequate. This might be due to the challenging
dual nature of pancreas with both endocrine and exocrine tissues. We aimed to
recellularization of acellular pieces with human fetal pancreatic stem cells for
14 days showed attached and proliferating cells. Both endocrine (C-peptide and
porcine pancreas, which when recellularized with human fetal pancreatic stem
treatment of diabetes.
DOI: 10.1177/2041731417738145
PMCID: PMC5669317
PMID: 29118967
the research, authorship, and/or publication of this article: S.S.H. holds shares
Mamakou V(1)(2), Hackinger S(3), Zengini E(4)(5), Tsompanaki E(6), Marouli E(7),
Serafetinidis I(8), Prins B(3), Karabela A(9), Glezou E(4), Southam L(3)(10),
E(3).
Author information:
vmamakou@hotmail.com.
(7)William Harvey Research Institute, Barts and The London School of Medicine and
Greece.
Greece.
Greece.
Athens, Greece.
Greece.
psychotropic treatment classes in patients with SCZ has not yet been evaluated.
The overarching goal of the Genetic Overlap between Metabolic and Psychiatric
METHODS: The GOMAP case-control study (Genetic Overlap between Metabolic and
Psychiatric disease) includes hospitalized patients with SCZ, some of whom have
T2D. We enrolled 1653 patients with SCZ; 611 with T2D and 1042 patients without
T2D. This is the first study of SCZ and T2D comorbidity at this scale in the
risk of T2D. Using logistic regression, we calculated crude and adjusted odds
psychiatric medications.
of psychiatric drugs had a higher risk of T2D [OR 1.81 (95% CI 1.22-2.69);
p = 0.003] compared to FGA alone therapy, after adjustment for age, BMI, sex,
duration of SCZ and number of hospitalizations. We did not find evidence for an
CONCLUSIONS: We find an increased risk of T2D in patients with SCZ who take a
DOI: 10.1186/s12888-018-1826-4
PMCID: PMC6090901
PMID: 30071838
51. Microarrays (Basel). 2016 Aug 10;5(3). pii: E21. doi: 10.3390/microarrays5030021.
Delalat B(1), Rojas-Canales DM(2)(3), Rasi Ghaemi S(4), Waibel M(5), Harding
Author information:
Darling.Rojas@sa.gov.au.
Australia. Darling.Rojas@sa.gov.au.
Daniella.Penko@sa.gov.au.
Chris.Drogemuller@sa.gov.au.
Australia. Chris.Drogemuller@sa.gov.au.
Toby.Coates@sa.gov.au.
Australia. Toby.Coates@sa.gov.au.
space not only provides structural support, but also actively signals to regulate
islet survival and function. In addition, the ECM is responsible for growth
elements of the native islet environment, losses in islet function and number can
islet derived cell interaction with ECM proteins and immobilized growth factors
printed on arrays. MIN6 mouse insulinoma cells, mouse islets and, finally, human
to identify ECM and growth factor protein candidates that support islet viability
DOI: 10.3390/microarrays5030021
PMCID: PMC5040968
PMID: 27600088
interests exist.
52. Clin Epidemiol. 2017 Jan 25;9:63-65. doi: 10.2147/CLEP.S130096. eCollection 2017.
with type 1 and type 2 diabetes mellitus in a large primary care database",
Bocquet V(1).
Author information:
Health, Luxembourg.
DOI: 10.2147/CLEP.S130096
PMCID: PMC5279818
PMID: 28182137
Conflict of interest statement: The author reports no conflicts of interest in
this communication.
53. Evid Based Complement Alternat Med. 2018 Sep 13;2018:3248521. doi:
Qiu X(1), Wei X(2), Guan H(1), Su H(1), Gong J(1), Fang K(3), Zou X(1), Dong
Author information:
reported that CC powders are more effective than CC decoctions. In this study, a
weight, fasting plasma insulin, insulin resistance index, and lipid profiles were
measured along with oral glucose tolerance tests (OGTTs). In addition, the levels
of plasma proteins were compared between type 2 diabetic rats and CC-treated rats
using an iTRAQ-based quantitative proteomic analysis. The results showed that the
plasma levels of triglyceride (TC), total cholesterol (TG), and low-density
were selected from these 929 proteins based on their expression levels and
Igfbp-6, Igfals, C2, C4, Cfi, Prdx-2, and Prdx-3) were upregulated in the two
and ApoE) were downregulated. The functions of these proteins are associated with
oxidation, and antioxidation. The two differently extracted CC did not show
DOI: 10.1155/2018/3248521
PMCID: PMC6158947
PMID: 30302116
eCollection 2017.
Reisberg S(1)(2)(3), Iljasenko T(1), Läll K(4)(5), Fischer K(5), Vilo J(1)(2)(3).
Author information:
Polygenic risk scores are gaining more and more attention for estimating genetic
risks for liabilities, especially for noncommunicable diseases. They are now
calculated using thousands of DNA markers. In this paper, we compare the score
distributions of two previously published very large risk score models within
different populations. We show that the risk score model together with its risk
applied to another population without taking into account the target population's
DOI: 10.1371/journal.pone.0179238
PMCID: PMC5497939
Su M(1), Si Y(1), Zhou Z(2), Shen C(1), Dong W(3), Fan X(3), Wang X(4), Wei X(5).
Author information:
China.
China. zzliang1981@163.com.
Suzhou, China.
xiaolin.wei@utoronto.ca.
BACKGROUND: Hypertension has become a global health challenge given its high
prevalence and but low awareness and detection. Whether the actual prevalence of
hypertension has been estimated is important, especially for the poor. This study
METHODS: Data were derived from China Health and Nutrition Survey (CHNS)
12,168 respondents aged 18 or older were identified for analysis. Both tested
prevalence.
were 28.8% [95% CI (28.0%, 29.6%)] and 15.7% [95% CI (15.0%, 16.3%)], and 26.4%
[95% CI (25.1%, 27.6%)] and 19.0% [95% CI (17.9%, 20.1%)] in urban areas, and
30.3% [95% CI (29.3%, 31.4%)] and 13.5% [95% CI (12.7%, 14.3%)] in rural areas.
key factors of the pro-poor inequity in tested prevalence. Economic status, area
and age were key factors to explain the poor-rich inequity in self-reported
prevalence.
much lower than tested prevalence in China, while a larger gap between
self-reported and tested prevalence was found in rural areas. Our study suggested
in rural area need be strengthened by health education programs and improving the
access to public health service, especially for those who do not engage with
DOI: 10.1186/s12939-018-0796-y
PMCID: PMC6003002
PMID: 29907150
eCollection 2017.
layers thickness measurements between healthy and diabetic eyes among Chinese
adults.
Author information:
volume scans (30° * 25°) were obtained for 133 type 2 diabetes mellitus (T2DM)
patients with no DR, 42 T2DM patients with mild DR and 115 healthy controls. The
mean thickness was measured in all 9 Early Treatment Diabetic Retinopathy Study
(ETDRS) sectors for 8 separate layers, inner retinal layer (IRL), outer retinal
layer (ORL) and total retina (TR), after automated segmentation. The ETDRS grid
consisted of three concentric circles of 1-, 3-, and 6-mm diameter. The superior,
inferior, temporal, and nasal sectors of the 3- and 6-mm circles were
respectively designated as S3, I3, T3, and N3 and S6, I6, T6, and N6. Linear
and HbA1c.
RESULTS: The mean age and duration of T2DM were 61.1 and 13.7 years,
volumes were observed among the groups, significant differences were found in the
volume and sectorial thicknesses of the inner plexiform layer (IPL), outer
plexiform layer (OPL) and IRL among the groups. In particular, the thicknesses of
the IPL (S3, T3, S6, I6 and T6 sectors) and the IRL (S6 sector) were decreased in
the no-DR group compared with the controls (P < 0.05). The thickness of the OPL
(S3, N3, S6 and N6 sectors) was thinner in the no-DR group than in mild DR (P <
0.05). The average IPL thickness was significantly negatively correlated with age
significant decrease in the IPL and IRL thicknesses in Chinese adults with T2DM,
DOI: 10.1371/journal.pone.0177515
PMCID: PMC5426752
PMID: 28493982 [Indexed for MEDLINE]
57. Int J Mol Sci. 2017 Sep 21;18(10). pii: E2010. doi: 10.3390/ijms18102010.
Diabetes.
Author information:
South Florida, 12901 Bruce B. Downs Blvd. MDC07, Tampa, FL 33620, USA.
duzh@szu.edu.cn.
South Florida, 12901 Bruce B. Downs Blvd. MDC07, Tampa, FL 33620, USA.
vuversky@health.usf.edu.
University of South Florida, 12901 Bruce B. Downs Blvd. MDC07, Tampa, FL 33620,
USA. vuversky@health.usf.edu.
diabetes mellitus, proteins play several important roles. The Kyoto Encyclopedia
of Genes and Genomes (KEGG) database has information on 34 human proteins
study shows that T2DM is not an exception to this rule, and many proteins known
for the intrinsic disorder characterization revealed that IRS1, IRS2, IRS4, MAFA,
PDX1, ADIPO, PIK3R2, PIK3R5, SoCS1, and SoCS3 are expected to be highly
disordered, whereas VDCC, SoCS2, SoCS4, JNK9, PRKCZ, PRKCE, insulin, GCK, JNK8,
JNK10, PYK, INSR, TNF-α, MAPK3, and Kir6.2 are classified as moderately
disordered proteins, and GLUT2, GLUT4, mTOR, SUR1, MAPK1, IKKA, PRKCD, PIK3CB,
and PIK3CA are predicted as mostly ordered. More focused computational analyses
and intensive literature mining were conducted for a set of highly disordered
describing the major biological functions of these proteins and functional roles
studies that may uncover latent and novel pathways associated with the disease.
DOI: 10.3390/ijms18102010
PMCID: PMC5666700
eCollection 2018.
Chang PY(1), Chien LN(2), Bai CH(1), Lin YF(3), Chiou HY(1).
Author information:
Taipei, Taiwan.
Taiwan.
Taiwan.
Purpose: Effective management for type 2 diabetes mellitus (DM) can slow the
of care (COC) was found to improve patients' adherence and self-management. This
study examined the associations between COC, hospitalization, and end-stage renal
Patients and methods: In the cohort study, data from 1996 to 2012 were retrieved
weighted analysis. A total of 26,063 patients with newly diagnosed type 2 DM who
had been treated with antihyperglycemic agents were included. COC is to assess
the extent to which a DM patient visited the same physician during the study
period. This study categorized COC into 3 groups - low, intermediate, and high, -
Results: The number of ESRD patients in the high, intermediate, and low COC
groups were 92 (22.33%), 130 (31.55%), and 190 (46.12%), respectively, and the
mean follow-up periods for the 3 groups were 7.13, 7.12, and 7.27 years,
respectively. After using inverse probability weighting, the intermediate and low
COC groups were significantly associated with an increased risk of ESRD compared
with the high COC group (adjusted hazard ratio (aHR) 1.36 [95% CI, 1.03-1.80] and
aHR 1.76 [95% CI, 1.35-2.30], respectively). The intermediate and low COC groups
with the high COC group (aHR 1.15 [95% CI, 0.99-1.33] and aHR 1.72 [95% CI,
1.50-1.97], respectively).
patients with DM. This study suggested that when DM patients keep visiting the
same physician for managing their diseases, the progression of renal disease can
be prevented.
DOI: 10.2147/TCRM.S150638
PMCID: PMC5856058
PMID: 29559787
59. Biosensors (Basel). 2018 Apr 25;8(2). pii: E43. doi: 10.3390/bios8020043.
Detection: Looking at the Problem from the Other Side of the Coin.
Bila R(1), Varo R(2)(3), Madrid L(4)(5), Sitoe A(6), Bassat Q(7)(8)(9)(10).
Author information:
rubao.bila@manhica.net.
Rosauro.Varo@manhica.net.
lola.madrid@isglobal.org.
lola.madrid@isglobal.org.
antonio.sitoe@manhica.net.
quique.bassat@isglobal.org.
quique.bassat@isglobal.org.
quique.bassat@isglobal.org.
The appearance, over a decade ago, of continuous glucose monitoring (CGM) devices
glycaemic control and quality of life. Such devices, the use of which remains
many other urgent health priorities beyond diabetes prevention and management
still need to be resolved. In this commentary, we argue that such devices could
selectively used among severely ill children admitted to hospital for closer
DOI: 10.3390/bios8020043
PMCID: PMC6023081
60. Int J Epidemiol. 2018 Mar 19. doi: 10.1093/ije/dyy016. [Epub ahead of print]
Zhang WZ, Bennett J, Bilano V, Stevens GA, Cowan MJ, Riley LM, Chen Z, Hambleton
IR, Jackson RT, Kengne AP, Khang YH, Laxmaiah A, Liu J, Malekzadeh R, Neuhauser
Amouyel P, Amuzu A, Andersen LB, Anderssen SA, Ängquist LH, Anjana RM, Ansong D,
KK, Aspelund T, Assah FK, Assunção MCF, Avdicová M, Azevedo A, Azizi F, Babu BV,
Barbagallo CM, Barceló A, Barkat A, Barros AJD, Barros MV, Bata I, Batieha AM,
Batyrbek A, Baur LA, Beaglehole R, Romdhane HB, Benet M, Benson LS, Bernabe-Ortiz
Carlsson AC, Carvalho MJ, Casanueva FF, Casas JP, Caserta CA, Chamukuttan S, Chan
AW, Chan Q, Chaturvedi HK, Chaturvedi N, Chen CJ, Chen F, Chen H, Chen S, Chen Z,
Cottel D, Cowell C, Craig CL, Crujeiras AB, Cruz JJ, D'Arrigo G, d'Orsi E,
Evans A, Faeh D, Fall CH, Farzadfar F, Felix-Redondo FJ, Ferguson TS, Fernandes
Fischer K, Föger B, Foo LH, Forslund AS, Forsner M, Fouad HM, Francis DK, do
Carmo Franco M, Franco OH, Frontera G, Fuchs FD, Fuchs SC, Fujita Y, Furusawa T,
Henriques A, Cadena LH, Herrala S, Heshmat R, Hihtaniemi IT, Ho SY, Ho SC, Hobbs
M, Hofman A, Dinc GH, Horimoto ARVR, Hormiga CM, Horta BL, Houti L, Howitt C,
Htay TT, Htet AS, Than Htike MM, Hu Y, Huerta JM, Huisman M, Husseini AS,
Huybrechts I, Hwalla N, Iacoviello L, Iannone AG, Ibrahim MM, Wong NI, Ikeda N,
Ikram MA, Irazola VE, Islam M, Al-Safi Ismail A, Ivkovic V, Iwasaki M, Jackson
Kerimkulova A, Kersting M, Key T, Khader YS, Khalili D, Khang YH, Khateeb M, Khaw
R, Kuciene R, Kuh D, Kujala UM, Kulaga Z, Krishna Kumar R, Kurjata P, Kusuma YS,
C, Lee J, Lee J, Lehtimäki T, León-Muñoz LM, Levitt NS, Li Y, Lilly CL, Lim WY,
Lima-Costa MF, Lin HH, Lin X, Lind L, Linneberg A, Lissner L, Litwin M, Liu J,
Martorell R, Mathiesen EB, Matijasevich A, Matsha TE, Mbanya JCN, Mc Donald Posso
AJ, McFarlane SR, McGarvey ST, McLachlan S, McLean RM, McLean SB, McNulty BA,
GR, Meshram II, Metspalu A, Meyer HE, Mi J, Mikkel K, Miller JC, Minderico CS,
LT, Møller NC, Molnár D, Momenan A, Mondo CK, Monyeki KDK, Moon JS, Moreira LB,
Nang EEK, Nangia VB, Narake S, Nauck M, Navarrete-Muñoz EM, Ndiaye NC, Neal WA,
Nenko I, Neovius M, Nervi F, Neuhauser HK, Nguyen CT, Nguyen ND, Nguyen QN,
Nguyen QV, Nieto-Martínez RE, Niiranen TJ, Ning G, Ninomiya T, Nishtar S, Noale
M, Noboa OA, Noorbala AA, Norat T, Noto D, Al Nsour M, O'Reilly D, Oda E, Oehlers
G, Oh K, Ohara K, Olinto MTA, Oliveira IO, Omar MA, Onat A, Ong SK, Ono LM,
WH, Panda-Jonas S, Panza F, Papandreou D, Park SW, Parnell WR, Parsaeian M, Patel
ND, Pecin I, Pednekar MS, Peer N, Peeters PH, Peixoto SV, Peltonen M, Pereira AC,
JJ, Puiu M, Punab M, Qasrawi RF, Qorbani M, Bao TQ, Radic I, Radisauskas R,
L, Rampal S, Rangel Reina DA, Redon J, Reganit PFM, Ribeiro R, Riboli E, Rigo F,
Sánchez-Abanto J, Sans S, Santos DA, Santos IS, Nunes Dos Santos R, Santos R,
Saramies JL, Sardinha LB, Sarganas G, Sarrafzadegan N, Saum KU, Savva S, Scazufca
Sein AA, Sen A, Senbanjo IO, Sepanlou SG, Sharma SK, Shaw JE, Shibuya K, Shin DW,
Shin Y, Si-Ramlee K, Siantar R, Sibai AM, Santos Silva DA, Simon M, Simons J,
Song Y, Sørensen TIA, Soric M, Jérome CS, Soumare A, Staessen JA, Starc G,
Strufaldi MW, Sun CA, Sundström J, Sung YT, Suriyawongpaisal P, Sy RG, Shyong Tai
E, Tammesoo ML, Tamosiunas A, Tan EJ, Tang X, Tanser F, Tao Y, Tarawneh MR,
BH, Tjonneland A, Tolonen HK, Tolstrup JS, Topbas M, Topór-Madry R, Tormo MJ,
Tynelius P, Tzourio C, Ueda P, Ugel EE, Ulmer H, Uusitalo HMT, Valdivia G, Valvi
D, van der Schouw YT, Van Herck K, Van Minh H, van Rossem L, Van Schoor NM, van
Bebakar WM, Wan Mohamud WN, Wanderley RS Jr., Wang MD, Wang Q, Wang YX, Wang YW,
Widyahening IS, Wiecek A, Wijga AH, Wilks RJ, Willeit J, Willeit P, Williams EA,
Wilsgaard T, Wojtyniak B, Wong-McClure RA, Wong JYY, Wong TY, Woo J, Woodward M,
Cisneros JZ.
combined effects of public health interventions and secular trends) and changes
quantify the contributions of these two phenomena to the worldwide trends in the
on 88.6 million participants from 1985 to 2016. We first calculated mean systolic
blood pressure (SBP), mean diastolic blood pressure (DBP) and prevalence of
raised blood pressure by sex and 10-year age group from 20-29 years to
70-79 years in each study, taking into account complex survey design and survey
sample weights, where relevant. We used a linear mixed effect model to quantify
contributions of change in mean SBP and DBP, and of change in the prevalence-mean
Results: In 2005-16, at the same level of population mean SBP and DBP, men and
women in South Asia and in Central Asia, the Middle East and North Africa would
have the highest prevalence of raised blood pressure, and men and women in the
high-income Asia Pacific and high-income Western regions would have the lowest.
declined, one half or more of the decline was due to the decline in mean blood
pressure. Where prevalence of raised blood pressure has increased, the change was
entirely driven by increasing mean blood pressure, offset partly by the change in
Conclusions: Change in mean blood pressure is the main driver of the worldwide
DOI: 10.1093/ije/dyy016
PMCID: PMC6005056
PMID: 29579276
Li J(1), Parrott S(1), Sweeting M(2), Farmer A(3), Ross J(4), Dack C(5), Pal
K(4), Yardley L(3)(6), Barnard M(7), Hudda M(8), Alkhaldi G(9), Murray E(4).
Author information:
Kingdom.
United Kingdom.
conditions, and costs health services approximately 10% of their total budget.
education was low, the development of internet-based technology might improve the
situation.
National Health Service and personal and social services perspective, based on
trial over 12 months. Adults aged 18 or over with a diagnosis of type 2 diabetes
England, UK, were approached. People who were unable to provide informed consent
participants' intervention costs and wider health care resource use were
Areas in Diabetes (PAID) Scale and EQ-5D-3L. EQ-5D-3L was then used to calculate
RESULTS: In total, 374 participants were randomized, with 185 in the intervention
group and 189 in the control group. The primary analysis showed incremental
PAID scale and £5550 (95% CI -21,077 to 52,356) per QALY gained by HeLP-Diabetes,
ratios of £116 (95% CI -1299 to 1690) per unit improvement on PAID scale and
363 users would be needed to use the intervention for it to become less costly
usual care, under the recommended threshold of £20,000 to £30,000 per QALY by
National Institute of Health and Care Excellence.
WebCite at http://www.webcitation.org/6zqjhmn00).
©Jinshuo Li, Steve Parrott, Michael Sweeting, Andrew Farmer, Jamie Ross,
Charlotte Dack, Kingshuk Pal, Lucy Yardley, Maria Barnard, Mohammed Hudda, Ghadah
DOI: 10.2196/jmir.9256
PMCID: PMC6015272
PMID: 29884608
eCollection 2018.
Author information:
INTRODUCTION: Diabetes is the most common cause of chronic kidney disease, with a
OBJECTIVE: To estimate the cost of chronic kidney disease (CKD) and end-stage
kidney disease (ESKD) attributable to diabetes, stratified by sex, race/skin
color, and age, from the perspective of the Brazilian public health system
METHODS: Population attributable risk (PAR) was calculated from the Brazilian
prevalence of diabetes and the relative risk (or odds ratio) of persons with
variables of interest were sex, race/skin color, and age. A top-down approach was
used to measure the direct costs of the disease reimbursed by the Brazilian
RESULTS: The cost of CKD and ESKD attributable to diabetes in the period
2010-2016 was US$1.2 billion (US$180 million per year) and trending upward.
Female sex, age 65-75, and black race/skin color contributed substantially to the
costs of CKD and ESKD (US$475 million, US$63 million, and US$25 million
CONCLUSION: Diabetes accounted for 22% of the costs of CKD and ESKD. Female sex,
age 65-75 years, and black race/skin color were the variables which contributed
gradually in the coming years, with serious implications for the financial
DOI: 10.1371/journal.pone.0203992
PMCID: PMC6166929
PMID: 30273345
interests exist.
Jan 29.
Critical evaluation of causality assessment of herb-drug interactions in
patients.
Awortwe C(1)(2), Makiwane M(2), Reuter H(2), Muller C(1), Louw J(1), Rosenkranz
B(2).
Author information:
The aim of this review was to assess the severity of adverse drug reactions
PubMed, the Cochrane Library, Medline and Scopus were searched for randomized or
nonrandomized clinical studies, case-control and case reports of HDI. The data
case reports and two observational studies with 15 cases of ADRs were recorded.
patients resulting in clinical ADRs with different severity. Patients may poorly
either scenario may increase the cost of treatment and/or lead to or prolong
DOI: 10.1111/bcp.13490
PMID: 29363155
May 4.
Hu H(1), Nakagawa T(2), Okazaki H(3), Nishiura C(4), Imai T(5), Miyamoto T(6),
Sasaki N(7), Yamamoto M(8), Murakami T(9), Kochi T(10), Eguchi M(10), Tomita
K(11), Nagahama S(12), Kuwahara K(1)(13), Kabe I(10), Mizoue T(1), Dohi S(3).
Author information:
and Medicine.
(2)Hitachi, Ltd.
(5)Azbil Corporation.
(8)YAMAHA CORPORATION.
Health Study. Participants (46,065 men and 7,763 women) were aged 30-59 years,
type 2 diabetes was defined based on fasting and casual glucose, glycated
hemoglobin, and current medical treatment for type 2 diabetes. We calculated the
and 248 women) developed type 2 diabetes. The cumulative risk was 34.7% (95%
confidence interval, 33.1-36.3%) for men and 18.6% (95% confidence interval,
15.5-21.7%) for women. In BMI-stratified analysis, obese (BMI ≥30 kg/m2) and
overweight (BMI 25-29.9 kg/m2) men and women had a much higher cumulative risk of
type 2 diabetes (obese: 77.3% for men and 64.8% for women; overweight: 49.1% and
35.7%, respectively) than those with BMI <25 kg/m2 (26.2% and 13.4% for men and
women, respectively).
CONCLUSIONS: The present data highlight the public health burden of type 2
diabetes in the working population. There is a need for effective programs for
weight management and type 2 diabetes screening, especially for young obese
DOI: 10.2188/jea.JE20170093
PMCID: PMC6192974
PMID: 29731478
65. J Physiol Anthropol. 2018 Aug 29;37(1):20. doi: 10.1186/s40101-018-0181-y.
Current health status and its risk factors of the Tsarang villagers living at
Author information:
manakano@nagasaki-u.ac.jp.
manakano@nagasaki-u.ac.jp.
(11)Everest International Clinic and Research Center, GPO 9045, Kathmandu, Nepal.
(12)National Center for AIDS & STD Control, Ministry of Health and Population,
Nepal.
factors. This study aims to investigate the prevalence of NCDs and determine
their risk factors among the adults residing in an isolated village situated at a
questionnaire and took a full physical exam that included biomedical measurements
RESULTS: The prevalence of intermediate hyperglycemia and DM was 31.6% and 4.6%
respectively, and the prevalence of hypoxemia (SpO2 < 90%) was 27.1%. A multiple
intolerance (HbA1c ≥ 6%) revealed older age (odds ratio [OR] 1.11, 95% confidence
interval [CI] 1.06-1.16, for every 1 year increase) and SpO2 (OR for hypoxemia
Nepal have high prevalence of impaired glucose metabolism which could be related
DOI: 10.1186/s40101-018-0181-y
PMCID: PMC6114060
PMID: 30157969 [Indexed for MEDLINE]
66. Clin Nutr. 2018 Apr;37(2):712-718. doi: 10.1016/j.clnu.2017.02.022. Epub 2017 Mar
8.
Author information:
woonpuay.koh@duke-nus.edu.sg.
BACKGROUND & AIMS: The effect of total dairy products, milk, and calcium intake
population.
METHODS: The present study was based on a prospective cohort of 63,257 Chinese
men and women aged 45-74 years during enrollment (1993-1998) in Singapore.
RESULTS: Incidence rate (95% CI) of T2D was 10.5 (10.2-10.8) per 1000
person-years. Intake of dairy food was significantly associated with reduced T2D
risk; compared with the lowest quartile, HRs (95% CI) for the second, third and
fourth quartiles of dairy intake were 0.98 (0.91-1.06), 0.96 (0.89-1.03) and 0.90
(P-trend = 0.01). Daily drinkers of milk had a significant 12% reduction in T2D
risk compared with non-drinkers. While dairy calcium was associated with a
decreased risk of T2D (HR comparing extreme quartiles 0.84; 95% CI 0.76-0.93;
P-trend = 0.001), no association was found for non-dairy calcium (HR 1.02; 95% CI
CONCLUSIONS: In this large cohort study of Chinese adults, dairy product intake
Copyright © 2017 Elsevier Ltd and European Society for Clinical Nutrition and
DOI: 10.1016/j.clnu.2017.02.022
PMID: 28318689
eCollection 2017.
Author information:
(1)Department of Global Health and Center for Global Health and Development,
of America.
OBJECTIVE: The goal of this research was to identify the fraction of deaths
for cohorts aged 30-84 who were surveyed in the National Health Interview Survey
(NHIS) between 1997 and 2009 (N = 282,322) and in the National Health and
Nutrition Examination Survey (NHANES) between 1999 and 2010 (N = 21,814). Cohort
diabetes status using self-reported diagnoses in both NHIS and NHANES and using
HbA1c in NHANES. Hazard ratios associated with diabetes were estimated using Cox
model adjusted for age, sex, race/ethnicity, educational attainment, and smoking
status.
RESULTS: We found a high degree of consistency between data sets and definitions
11.7% using self-reports in NHANES, and 11.8% using HbA1c in NHANES. Among the
sub-groups that we examined, the PAF was highest among obese persons at 19.4%.
The proportion of deaths in which diabetes was assigned as the underlying cause
DOI: 10.1371/journal.pone.0170219
PMCID: PMC5266275
interests exist.
68. BMJ Open Diabetes Res Care. 2018 May 29;6(1):e000521. doi:
improving diabetes care indicators in Japanese patients with type 2 and type 1
Yokoyama H(1), Araki SI(2), Kawai K(3), Yamazaki K(3), Tomonaga O(4), Shirabe
Author information:
Research design and methods: Two independent cohorts were recruited with the same
inclusion criteria in 2004 (cohort 1: 3319 with type 2 and 286 with type 1
diabetes) and in 2014 (cohort 2: 3932 with type 2 and 308 with type 1 diabetes).
targets for glycemia, blood pressure, lipid control, body mass index (BMI), and
and their data were compared with the baseline data of each cohort.
diabetes were similarly found in each age-matched and sex-matched group, whereas
younger patients exhibited marked increase in BMI and lower treatment target
impairment, only a slight increase in the prevalence was observed both in type 2
years older.
Younger patients with type 2 diabetes exhibited marked increase in BMI and lower
remains a concern.
DOI: 10.1136/bmjdrc-2018-000521
PMCID: PMC5992467
PMID: 29892340
Ruiz PLD(1)(2)(3), Stene LC(4), Bakken IJ(5), Håberg SE(5), Birkeland KI(6)(7),
Gulseth HL(4)(8).
Author information:
Paz.Lopez-Doriga.Ruiz@fhi.no.
(5)Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo,
Norway.
Norway.
AIMS/HYPOTHESIS: This study aimed to examine recent time trends in the incidence
METHODS: In this Norwegian nationwide cohort study, we linked data from national
2014 by type of treatment, sex, age, education level and place of birth.
diagnosis. A low education level and being born in Asia, Africa or South America
were significant risk factors for incident type 2 diabetes. While the prevalence
of type 2 diabetes increased from 4.9% to 6.1% during the study period, the
incidence decreased significantly from 609 cases per 100,000 person-years in 2009
to 398 cases per 100,000 in 2014, an annual reduction of 10.1% (95% CI -10.5,
DOI: 10.1007/s00125-018-4681-4
PMCID: PMC6182655
PMID: 29995214
Author information:
(1)Department of Physiology, University of Toronto, St George Campus, Toronto,
retrospective cohort study conducted from July 2003 to Feb 2014 and followed up
until death or December 2016, female patients with early breast cancer who have
been treated for the first time at the Cancer Institute of Iran, were divided to
diabetic and non-diabetic groups. Primary and secondary outcomes were relapse
free survival (RFS) and overall survival (OS). SPSS version 23 was used for
analysis of data. Other variables included age, tumor stage, hormone receptor
status, tumor subtype, and patient’s body mass index (BMI). Result: From a total
of 1021 patients, 218 (21.4%) had type 2 diabetes mellitus. Diabetic patients had
a higher mean age (53.31 vs 47.00), higher mean BMI (31.13 vs 29.15), lower HER2
51.0). Overall, after adjustment of other variables, diabetes status did not
154.701) and RFS (114.107 vs 133.612) as well as OS higher hazard ratio of 1.830
and RFS hazard ratio of 1.663 compared to non-diabetic patients. BMI, hormone
receptor status and tumor stage significantly affected the survival of the
risk factors, BMI and type 2 diabetes mellitus had an independent impact on
PMCID: PMC5720655
PMID: 28952281
Karst SG(1), Lammer J(1), Mitsch C(1), Schober M(1), Mehta J(1)(2), Scholda C(1),
Author information:
Austria.
Austria. ursula.schmidt-erfurth@meduniwien.ac.at.
Comment in
PURPOSE: Our purpose was to compare the impact in diabetic macula edema (DME) of
images, color fundus photography (CF) and fluorescein angiography (FA) images
FA and CF images of eyes with a center involving DME that were included in a
random into two groups receiving either pro re nata treatment with 0.5 mg
n = 15) were included in this study. Patients treated with ranibizumab showed
both groups. The initial effect on macular edema shedding after a single
ranibizumab injection could be amplified with the following two injections of the
effect on the macula edema faded within 3 months. Subretinal fluid and INL
FA, the area of leakage diminished significantly in both treatment arms. After
arms converged.
CONCLUSIONS: Despite the higher dosage of triamcinolone, both therapies were safe
and effective for treating diabetic macular edema. Fluid accumulation in the INL
and subretinal space was more responsive to therapy than fluid accumulation in
DOI: 10.1007/s00417-017-3828-1
PMCID: PMC5748439
Subramanian S(1), Tangka F(2), Edwards P(3), Hoover S(3), Cole-Beebe M(3).
Author information:
(1)RTI International, 3040 E. Cornwallis Rd., Research Triangle Park, NC, USA.
(2)Centers for Disease Control and Prevention, 4770 Buford Hwy, Atlanta, GA, USA.
(3)RTI International, 3040 E. Cornwallis Rd., Research Triangle Park, NC, USA.
BACKGROUND: This article reports on the methods and framework we have developed
METHODS: We developed a cost data collection instrument, the Centers for Disease
in-depth case studies, site visit interviews, and pilot testing in 11 registries
from multiple countries including India, Kenya, Uganda, Colombia, and Barbados to
assess the overall quality of the data collected from cancer and cardiovascular
registries.
RESULTS: Overall, the registries were able to use the IntRegCosting Tool to
were able to provide accurate estimation of labor costs, which is the largest
influence the cost of registry operations, including size of the geographic area
served, data collection approach, local cost of living, presence of rural areas,
funding.
CONCLUSION: Internal and external registry factors reveal that a single estimate
for the cost of registry operations is not feasible; costs will vary on the basis
of factors that may be beyond the control of the registries. Some factors, such
registry operations. These findings will inform both future economic data
DOI: 10.1016/j.canep.2016.10.003
PMCID: PMC5840872
Development and Validation of a Simple Risk Score for Undiagnosed Type 2 Diabetes
in a Resource-Constrained Setting.
Author information:
School of Public Health, Johns Hopkins University, Baltimore, MD, USA; Área de
Investigación y Desarrollo, Asociación Benéfica PRISMA, Lima, Peru.
Lima, Peru.
Cayetano Heredia, Lima, Peru; Division of Pulmonary and Critical Care, School of
population-based studies in Peruvian population aged ≥35 years were used in the
analysis: the ENINBSC survey (n = 2,472) and the CRONICAS Cohort Study (n =
2,945). Fasting plasma glucose ≥7.0 mmol/L was used to diagnose diabetes in both
studies. Coefficients for risk score were derived from the ENINBSC data and then
the performance was validated using both baseline and follow-up data of the
CRONICAS Cohort Study. Results. The prevalence of undiagnosed diabetes was 2.0%
in the ENINBSC survey and 2.9% in the CRONICAS Cohort Study. Predictors of
circumference. Score values ranged from 0 to 4, with an optimal cutoff ≥2 and had
a moderate performance when applied in the CRONICAS baseline data (AUC = 0.68;
95% CI: 0.62-0.73; sensitivity 70%; specificity 59%). When predicting incident
cases, the AUC was 0.66 (95% CI: 0.61-0.71), with a sensitivity of 69% and
specificity of 59%. Conclusions. A simple nonblood based risk score based on age,
simple screening tool for undiagnosed and incident cases of diabetes in Peru.
DOI: 10.1155/2016/8790235
PMCID: PMC5027039
PMID: 27689096
Author information:
Florida, 12901 Bruce B. Downs Blvd, Tampa, FL, 33592, USA. trieg@health.usf.edu.
California San Diego, 3350 La Jolla Village Drive, San Diego, CA, 92161, USA.
vvallon@ucsd.edu.
USA. vvallon@ucsd.edu.
(4)VA San Diego Healthcare System, San Diego California, San Diego, CA, USA.
vvallon@ucsd.edu.
epithelial glucose transport. While SGLT1 accounts for most of the dietary
glucose uptake in the intestine, SGLT2 is responsible for the majority of glucose
reuptake in the tubular system of the kidney, with SGLT1 reabsorbing the
with glucosuria. Since the cloning of SGLT1 more than 30 years ago, big strides
have been made in our understanding of these transporters and their suitability
starting point for the development of specific inhibitors of SGLT1 and SGLT2, as
well as dual SGLT1/2 inhibitors. Since the approval of the first SGLT2 inhibitor
in 2013 by the US Food and Drug Administration, SGLT2 inhibitors have become a
new mainstay in the treatment of type 2 diabetes mellitus. They also have
beneficial effects on the cardiovascular system (including heart failure) and the
kidney. This review focuses on the rationale for the development of individual
SGLT2 and SGLT1 inhibitors, as well as dual SGLT1/2 inhibition, including, but
of metabolism.
DOI: 10.1007/s00125-018-4654-7
PMID: 30132033
Apr 30.
Insulin Glargine U100 in Basal-Bolus Regimens for Type 2 Diabetes in the UK.
Pollock RF(1), Valentine WJ(2), Marso SP(3), Gundgaard J(4), Hallén N(4), Hansen
Author information:
pollock@ossianconsulting.com.
INTRODUCTION: The aim of this study was to evaluate the short-term cost-utility
U100) for the treatment of type 2 diabetes in the basal-bolus subgroup of the
METHODS: A cost-utility analysis was conducted over a 2-year time horizon using a
UK-specific costs (expressed in 2016 GBP) were obtained from the literature. The
analysis was conducted from the perspective of the National Health Service.
RESULTS: Degludec was associated with mean cost savings of GBP 28.78 per patient
relative to glargine U100 in patients with type 2 diabetes at high CV risk. Cost
with degludec, which offset the higher treatment costs relative to glargine U100.
CONCLUSION: The present short-term modeling analysis found that for the
degludec was cost neutral (no additional costs) compared with glargine U100 over
a 2-year time horizon in the UK setting. Furthermore, there were QALY gains with
degludec, particularly due to the reduction in the risk of severe hypoglycemia.
DOI: 10.1007/s13300-018-0430-4
PMCID: PMC5984933
PMID: 29713962
76. Clin Nutr Res. 2018 Oct;7(4):229-240. doi: 10.7762/cnr.2018.7.4.229. Epub 2018
Oct 23.
Lee HJ(1), Seo HI(1), Cha HY(1), Yang YJ(1), Kwon SH(1), Yang SJ(1).
Author information:
Korea.
sugar diets and physical/mental stress can cause hyperglycemia, one of main
impairment of brain cells and nerves, hemorrhage of cerebral blood vessel, and
DOI: 10.7762/cnr.2018.7.4.229
PMCID: PMC6209735
PMID: 30406052
Million Adults.
(4)MRC/Wits Rural Public Health and Health Transitions Research Unit, School of
Africa.
and treatment services. However, to our knowledge there has been no prior
effective policies.
sociodemographic characteristics.
representative, population-based study carried out between 2012 and 2014. A total
of 1 320 555 adults 18 years or older with plasma glucose (PG) and blood pressure
Exposures: State, rural vs urban location, age, sex, household wealth quintile,
fasted or ≥200 mg/dL if the participant had not fasted) and hypertension
Results: Of the 1 320 555 adults, 701 408 (53.1%) were women. The crude
prevalence of diabetes and hypertension was 7.5% (95% CI, 7.3%-7.7%) and 25.3%
(95% CI, 25.0%-25.6%), respectively. Notably, hypertension was common even among
younger age groups (eg, 18-25 years: 12.1%; 95% CI, 11.8%-12.5%). Being in the
richest household wealth quintile compared with being in the poorest quintile was
percentage points; 95% CI, 2.53-3.08 and urban: 3.47 percentage points; 95% CI,
3.03-3.91) and hypertension (rural: 4.15 percentage points; 95% CI, 3.68-4.61 and
urban: 3.01 percentage points; 95% CI, 2.38-3.65). The differences in the
hypertension varied from 3.2% (95% CI, 2.7%-3.7%) to 19.9% (95% CI, 17.6%-22.3%),
and 18.0% (95% CI, 16.6%-19.5%) to 41.6% (95% CI, 37.8%-45.5%), respectively.
and old age across all geographical areas and sociodemographic groups in India,
and hypertension prevalence among young adults is higher than previously thought.
Evidence on the variations in prevalence by state, age group, and rural vs urban
DOI: 10.1001/jamainternmed.2017.8094
PMID: 29379964
eCollection 2017.
Diabetes and Sepsis: Risk, Recurrence, and Ruination.
Author information:
and a 10% mortality risk. When patients with sepsis demonstrate elevated serum
continues to steadily climb after recovery from the acute event. Traditionally,
mortality. However, a closer examination of those who die long after sepsis
diabetic individuals suffer the highest infection rates. Recent reports suggest
that even after clinical "recovery" from sepsis, persistent alterations in innate
diabetic mortality from sepsis is predicted to rise dramatically over the next
cell defects that persist following sepsis are crucial to identify potential
DOI: 10.3389/fendo.2017.00271
PMCID: PMC5670360
PMID: 29163354
79. Diabetes Care. 2018 Aug;41(8):1646-1653. doi: 10.2337/dc18-0277. Epub 2018 Jun 1.
Warren B(1), Rebholz CM(1), Sang Y(1), Lee AK(1), Coresh J(1)(2), Selvin E(1)(2),
Grams ME(3)(2).
Author information:
Baltimore, MD.
Baltimore, MD mgrams2@jhmi.edu.
diabetes). We used linear mixed models with random intercepts and slopes to
over 26 years.
RESULTS: Adjusted mean eGFR decline over the full study period among participants
without diabetes was -1.4 mL/min/1.73 m2/year (95% CI -1.5 to -1.4), with
(difference vs. no diabetes, P < 0.001), and with diagnosed diabetes was -2.5
0.001). Among participants with diagnosed diabetes, risk factors for steeper eGFR
decline included African American race, APOL1 high-risk genotype, systolic blood
Those with diagnosed diabetes declined almost twice as rapidly as those without
diabetes. Among people with diagnosed diabetes, steeper declines were seen in
those with modifiable risk factors, including hypertension and glycemic control,
DOI: 10.2337/dc18-0277
2018 Jun.
Diabetes care in figures: current pitfalls and future scenario.
Author information:
Gerais Brazil.
threat to public health, healthcare systems and economy, due to the cascade of
resulted in 2.3 times higher prevalence in the year 2014. In contrast, while the
epidemic developments were kept much better under control compared to all other
regions in the world. Although both non-modifiable and modifiable risk factors
modifiable risk factor which, in turn, may strongly promote ageing process
DM-related crisis and provides prognosis for future scenarios on a global scale.
clinical onset of the disease), as the medicine of the future is the most
care. The key role of biomedical sciences in the future developments of diabetes
care is discussed.
DOI: 10.1007/s13167-018-0133-y
PMID: 29896313
declare that they have no conflict of interest.Patients have not been involved in
the study.No experiments have been performed including patients and/or animals.
10.15171/ijhpm.2016.79.
Author information:
(1)Department of Global Health and Public Policy, School of Public Health, Tehran
(3)College of Health and Life Sciences, Brunel University London, Uxbridge, UK.
The 21st century is an era of great challenge for humankind; we are combating
terrorism, climate change, poverty, human rights issues and last but not least
non-communicable diseases (NCDs). The burden of the latter has become so large
need of much greater attention. In light of this concern, the World Health
Organization (WHO) dedicated this year's World Health Day (held on April 7, 2016)
world. This editorial is an account of the macro politics in place for fighting
DOI: 10.15171/ijhpm.2016.79
PMCID: PMC5042585
Author information:
The disorders of gastrointestinal (GI) tract including intestine and colon are
common in the patients with diabetes mellitus (DM). DM induced intestinal and
colon which are associated with the symptoms frequently encountered in patients
gut microbiota change and colon cancer are discussed. The final goal is to
increase the understanding of DM-induced changes in the gut and the subsequent
DOI: 10.4239/wjd.v8.i6.249
PMCID: PMC5483424
PMID: 28694926
Diabetes knowledge and its association with the weight status among residents of
Author information:
hkutbi@kau.edu.sa.
Arabia.
and health characteristics and knowledge about diabetes and its symptoms and
complications was utilized. Data of 3978 adults, 18 years of age or older, were
collected from public mall sites in Jeddah city and surrounding areas.
Participants were divided into three tertiles based on their knowledge scores.
Weight and height were measured following standardized procedures, and body
weight categories were defined based on body mass index (BMI). The association
between weight status and tertiles of diabetes knowledge was examined using
underweight, overweight, or obese, did not differ with regards to knowledge about
diabetes symptoms. Adjusted models showed that overweight and obese participants
had lower odds of being in the lowest tertile of knowledge about diabetes
and OR: 0.64, 95% CI: 0.51-0.79, respectively). With regards to general knowledge
about diabetes, the knowledge of participants who were underweight did not differ
when compared to normal-weight participants. Overweight and obese participants
had lower odds of being in the lowest tertile of general knowledge about diabetes
compared to normal-weight participants (OR: 0.78, 95% CI: 0.62-0.97 and OR: 0.60,
take into account the level of diabetes knowledge and tailor interventions to aid
DOI: 10.1038/s41387-018-0055-8
PMCID: PMC6127130
PMID: 30190526
84. Cent Asian J Glob Health. 2017 Aug 25;6(1):271. doi: 10.5195/cajgh.2017.271.
eCollection 2017.
Author information:
(1)Grant and Service Contract Management Unit, Ministry of Public Health, Kabul,
Afghanistan.
identifies the risk factors associated with diabetes in Herat City, Afghanistan,
Surveillance (STEPS). We enrolled 1129 participants aged 25-70 years between May
and June of 2015 (47.4% males, 52.6% females). A structured questionnaire was
Results: We found that the prevalence of diabetes in Herat City was 9.9% (9.8% in
males and 10.1% in females). Of the 1129 respondents, only 3.3% were previously
diagnosed with diabetes or were under treatment, whereas 6.6% of respondents were
rice consumption, type of cooking oil, and systolic blood pressure were
Conclusions: This is one of the first studies to discuss the high prevalence of
DOI: 10.5195/cajgh.2017.271
PMCID: PMC5675391
PMID: 29138737
Metaanalysis.
Lee MR(1)(2)(3), Huang YP(3)(4)(5), Kuo YT(3)(6), Luo CH(3), Shih YJ(3), Shu
Author information:
(1)Department of Internal Medicine, National Taiwan University Hospital, Hsin-Chu
Branch, Taiwan.
Taiwan.
skin test or the interferon gamma release assay for diagnosis of LTBI and that
provided adjusted effect estimate for the association between diabetes and LTBI.
We searched PubMed and EMBASE through 31 January 2016. The risk of bias of
included studies was assessed using a quality assessment tool modified from the
Newcastle-Ottawa scale.
but nonsignificant risk of LTBI among diabetics (risk ratio, 4.40; 95% confidence
interval [CI], 0.50-38.55). For the cross-sectional studies, the pooled odds
ratio from the random-effects model was 1.18 (95% CI, 1.06-1.30), with a small
statistical heterogeneity across studies (I2, 3.5%). The risk of bias assessment
revealed several methodological issues, but the overall direction of biases would
risk for LTBI. Findings from this review could be used to inform future
diabetics.
© The Author 2016. Published by Oxford University Press for the Infectious
DOI: 10.1093/cid/ciw836
PMCID: PMC5399944
Author information:
mheisler@umich.edu.
(2)Center for Clinical Management Research (CCMR), Ann Arbor Veterans' Affairs
(VA) Healthcare System, 2215 Fuller Rd. (152), Ann Arbor, MI, 48105, USA.
mheisler@umich.edu.
(5)Center for Clinical Management Research (CCMR), Ann Arbor Veterans' Affairs
(VA) Healthcare System, 2215 Fuller Rd. (152), Ann Arbor, MI, 48105, USA.
(6)Global REACH and Department of Medical Education, University of Michigan
interventions for individuals at risk for developing diabetes are all essential
for diabetes prevention in Latin American countries (LACs). This scoping review
targeting Latino populations in the USA to explore possible lessons from these
strategies such as collaborations with local food stores and markets to promote
healthy behaviors.
DOI: 10.1007/s11892-016-0778-7
PMCID: PMC5180425
PMID: 27424069 [Indexed for MEDLINE]
87. Health Expect. 2018 Apr;21(2):549-559. doi: 10.1111/hex.12649. Epub 2017 Nov 22.
and caregivers?
Dogba MJ(1)(2), Dipankui MT(1), Chipenda Dansokho S(1), Légaré F(1)(2), Witteman
HO(1)(2)(3).
Author information:
[Health of populations and best health practices axis], Quebec City, QC, Canada.
Although research has improved its treatment and management, little is known
about which research topics matter to people living with diabetes, particularly
people living with any type of diabetes or caring for someone living with any
type of diabetes.
and caregivers of people with diabetes, asking them to rate the importance of 10
predetermined important research topics. We also held three focus groups in two
RESULTS: 469 adults (57% men, 42% women) in Canada completed the online survey,
indicating that all 10 areas of research mattered to them, with the highest
ratings accorded to preventing and treating kidney, eye and nerve complications.
Fourteen individuals participated in three focus groups and similarly noted the
population of people living with or caring for someone with diabetes. Findings
from this study were used to inform the vision for Diabetes Action Canada-a
© 2017 The Authors Health Expectations Published by John Wiley & Sons Ltd.
DOI: 10.1111/hex.12649
PMCID: PMC5867328
PMID: 29165920
Diabetes Update 2016: What Bartleby the Scrivener Can Teach Us About Diabetes
Care.
Semenkovich CF(1).
Author information:
Metabolism, and Lipid Research and Irene E. and Michael M. Karl Professor at
Washington University in St. Louis.
PMCID: PMC6139841
PMID: 30228500
89. Diabet Med. 2018 Nov;35(11):1538-1543. doi: 10.1111/dme.13783. Epub 2018 Aug 2.
diabetes mellitus.
A(1)(3)(4).
Author information:
question, 'Have you had difficulties obtaining an erection in the last 6 months?'
(yes/no). The risk scores used were the FINDRISC, LA-FINDRISC, American Diabetes
Association score and the Peruvian Risk Score. A Poisson regression model was
RESULTS: A total of 799 men with a mean (sd) age of 48.6 (10.7) years were
included in the study. The overall prevalence of Type 2 diabetes was 9.3%.
Compared with healthy men, men with Type 2 diabetes had 2.71 (95% CI 1.57-4.66)
higher chances of having erectile dysfunction. Having excluded men aware of Type
curve of three of the risk scores (not the American Diabetes Association score)
improved among those who had erectile dysfunction in comparison with those who
did not; for example, the area under the receiver-operating characteristic curve
of the LA-FINDRISC score was 89.6 (95% CI 78.7-99.9) in men with erectile
men with Type 2 diabetes than in the otherwise healthy men. Screening for
erectile dysfunction before screening for Type 2 diabetes seems to improve the
© 2018 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on
DOI: 10.1111/dme.13783
PMCID: PMC6221030
PMID: 30028534
Autonomic Neuropathy.
Author information:
(2)2 Centre for Research in Complex Systems and School of Community Health,
Australia.
AIMS: Cardiac autonomic reflex tests (CARTs) are time consuming and require
patient cooperation for detecting cardiac autonomic neuropathy (CAN). Heart rate
complete. However the reliability of HRV results as a clinical tool, with respect
controls and 63 for early CAN. Inclusion criteria were that participants were
medication free and presented with no comorbidities. ECGs of control and eCAN
were recorded and heart rate changes analyzed with the fast Fourier transform
determined.
RESULTS: The eCAN group was older ( P < .001) and systolic blood pressure was
higher ( P < .01). HDL-cholesterol was also higher in the eCAN group ( P < .05).
HRV analysis showed that both FFT and LSP results were significantly different
between eCAN and control down to a 10-second ECG length for low frequency (LSP: P
= .013, FFT: P = .024) and high frequency (HF-LSP: P = .002, FFT: P = .002)
CONCLUSION: HRV is suitable for clinical practice from ECG recordings of more
than 90 seconds with high accuracy and repeatability within a session for each
participant.
DOI: 10.1177/1932296817703670
PMCID: PMC5951037
Author information:
(1)Hellenic Medical Society for the study of Risk Factors in Vascular Diseases, 8
(2)Hellenic Medical Society for the study of Risk Factors in Vascular Diseases, 8
less than 300 Km2 and 5000 inhabitants each, comprising a total population of
of special interest. The objective of the present study was to assess lifestyle
anthropometric parameters, blood pressure and a full blood panel for glucose and
lipids.
RESULTS: The analysis included 596 individuals who represented 74.5% of the
target population. The mean age of the population was 49.5 ± 19.6 years and 48.2%
were 7.7%, 30.9% and 30.9% respectively, with screen-detection of each condition
accounting for an additional 4.0%, 12.9%, and 23.3% of cases, respectively. Four
hundred and seven individuals (68.3%) were overweight or obese, 25% reported
being physically inactive and 36.6% were active smokers. The median MedDietScore
associated with older age, better education, increased physical activity, absence
CONCLUSIONS: Obesity and traditional risk factors for CVD are highly prevalent
DOI: 10.1186/s12889-017-4053-x
PMCID: PMC5286858
Author information:
USA. hayley.billingsley@vcuhealth.org.
USA. salvatore.carbone@vcuhealth.org.
(3)John Ochsner Heart and Vascular Institute, Ochsner Clinical School, University
The role of dietary fat has been long studied as a modifiable variable in the
recent evidence suggests that a diet high in healthy fat, rich in unsaturated
fatty acids, such as the Mediterranean dietary pattern, may, in fact, prevent the
these fatty acids over time with measured cardiometabolic health outcomes,
through which unsaturated fatty acids may exert their beneficial effects. The
state of current knowledge on the associations between dietary fatty acids and
DOI: 10.3390/nu10101385
PMCID: PMC6213917
PMID: 30274325
Kuyper EM(1), Engle-Stone R(2), Arsenault JE(2), Arimond M(2), Adams KP(2), Dewey
KG(2).
Author information:
evaluate the degree to which a nation's food supply could support healthy diets
chronic disease and supports adequate micronutrient intakes. We used the DASH
Cameroon. Food availability was estimated using FAO Food Balance Sheet data on
country-level food supply. For each of the seven food groups in the 'healthy'
diet, we calculated the difference between the estimated national supply (in
RESULTS: In Cameroon, dairy and other animal-source foods were not adequately
available to meet healthy diet recommendations: the deficit was -365 kcal (-1527
kJ)/capita per d for dairy products and -185 kcal (-774 kJ)/capita per d for
meat, poultry, fish and eggs. Adequacy of fruits and vegetables depended on food
kcal (-457 kJ)/capita per d for fruits and -94 kcal (-393 kJ)/capita per d for
vegetables.
dietary patterns.
DOI: 10.1017/S1368980017001173
PMCID: PMC5582405
94. Oxid Med Cell Longev. 2018 Mar 26;2018:7487816. doi: 10.1155/2018/7487816.
eCollection 2018.
Dietary Total Antioxidant Capacity and Dietary Polyphenol Intake and Prevalence
Author information:
Poland.
Lodz, Poland.
Specific classes and subclasses of polyphenols have been studied for their
dietary polyphenol intake (DPI) and dietary total antioxidant capacity (DTAC) and
MetS (metabolic syndrome) are scarce. Therefore, the aim of this study was to
determine associations between DTAC and DPI and the prevalence of MetS and its
Federation (IDF) and the American Heart Association/National Heart, Lung, and
24-hour dietary recall. DTAC and DPI were evaluated using the data of food
consumption and antioxidant potential of foods, measured by FRAP (ferric reducing
relationship between DTAC and DPI and MetS and its components. Crude,
demonstrated that in Polish women, high DPI and high DTAC were significantly
associated with a reduced odds ratio for the prevalence of MetS components, such
as elevated blood pressure and diabetes. In contrast, in men, high DPI and high
DOI: 10.1155/2018/7487816
PMCID: PMC5892227
Kuwabara M(1)(2)(3), Kuwabara R(4), Niwa K(5), Hisatome I(6), Smits G(7),
Roncal-Jimenez CA(8), MacLean PS(9), Yracheta JM(10), Ohno M(11), Lanaspa MA(12),
Author information:
kuwamasa728@gmail.com.
Japan. kuwamasa728@gmail.com.
(4)Department of Pediatrics, Nihon University School of Medicine, Tokyo 173-8610,
Japan. remi.kuwabara@gmail.com.
Japan. kniwa@aol.com.
USA. jmy5@uw.edu.
minotky@gmail.com.
diana-jalal@uiowa.edu.
and hyperuricemia. Here, we evaluated whether the same body mass index (BMI) for
the U.S. population conferred similar metabolic risk in Japan. This was a
cross-sectional analysis involving 90,047 Japanese adults (18⁻85 years) from St.
Luke's International Hospital, Tokyo, Japan and 14,734 adults from National
according to BMI in Japan and the U.S. The prevalence of hypertension, DM, and
dyslipidemia were significantly higher in the U.S. than Japan, whereas the
prevalence of hyperuricemia did not differ between countries. Higher BMI was an
both in Japan and in the U.S. after adjusting for age, sex, smoking and drinking
habits, chronic kidney disease, and other cardiovascular risk factors. The BMI
increased was significantly higher in the U.S. than in Japan (27 vs. 23 kg/m² for
hypertension, 29 vs. 23 kg/m² for DM, 26 vs. 22 kg/m² for dyslipidemia, and 27
U.S. The BMI cut-off above which the prevalence of cardio-metabolic risk factors
increases is significantly lower in Japan than the U.S., suggesting that the same
countries.
DOI: 10.3390/nu10081011
PMCID: PMC6115805
PMID: 30081468
Sampson M(1), Elwell-Sutton T(2), Bachmann MO(2), Clark A(2), Dhatariya KK(3),
Ferns C(3), Howe A(2), John WG(4), Rayman G(5), Swafe L(3), Turner J(3), Pascale
M(3).
Author information:
mike.sampson@nnuh.nhs.uk.
(2)Norwich Medical School (NMS), University of East Anglia (UEA), Norwich, UK.
UK.
The world diabetes population quadrupled between 1980 and 2014 to 422 million and
correctly risk stratify people for entry into prevention programmes, how
combinations of multiple 'at high risk' glycemic categories predict outcome, and
how the large recently defined 'at risk' population based on an elevated
these with paired fasting plasma glucose and HbA1c for randomisation into a very
large Type 2 diabetes prevention trial. Baseline discordance rate between highest
risk categories was 45.6%, and 21.3-37.0% of highest risk glycaemic categories
apart). Accurate risk stratification using both fasting plasma glucose and HbA1c
data, the use of paired baseline data, and awareness of diagnostic imprecision at
DOI: 10.1038/s41598-018-24662-y
PMCID: PMC5908912
PMID: 29674706
97. Int J Environ Res Public Health. 2018 Feb 8;15(2). pii: E294. doi:
10.3390/ijerph15020294.
Rosa MQM(1), Rosa RDS(2), Correia MG(3), Araujo DV(4), Bahia LR(5), Toscano
CM(6).
Author information:
Brazil. ctoscano@terra.com.br.
aim of this study was to estimate the total number and economic burden of
sources included the National Health Survey (NHS) and National database of
patients are hospitalized for these conditions more frequently that non-DM
DM, using the attributable risk methodology. We present number, average cost per
stratified by condition, state of the country, gender and age group. In 2014, a
was Int$845, 19% higher than hospitalization without DM. Hospitalizations due to
strategies.
DOI: 10.3390/ijerph15020294
PMCID: PMC5858363
PMID: 29419786
founding sponsors had no role in the design of the study; in the collection,
Author information:
Philadelphia, Pennsylvania.
Although the factors responsible for the recent increase in the prevalence of
diabetes worldwide are not entirely known, the morbidity associated with this
which the environment interacts with the genome and there is evidence that
type 1 and type 2 diabetes. This review provides a summary of DNA methylation and
complications. In studies where both DNA methylation and gene expression changes
were reported, DNA methylation status had a strong inverse correlation with gene
incorporates both genetic sequencing and DNA methylation data may be an effective
diagnostic approach for all types of diabetes and could lead to additional
innovative therapies.
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
DOI: 10.1111/pedi.12521
PMCID: PMC5394941
Jun 8.
Early metabolic markers identify potential targets for the prevention of type 2
diabetes.
Author information:
(1)Institute for Molecular Medicine Finland (FIMM), Nordic EMBL Partnership for
gopal.peddinti@vtt.fi.
gopal.peddinti@vtt.fi.
(3)Metabolon Inc., Durham, NC, USA.
QLD, Australia.
Villejuif, France.
(11)Institute for Molecular Medicine Finland (FIMM), Nordic EMBL Partnership for
(13)Folkhalsan Research Center and Research Programs Unit, Diabetes and Obesity,
Finland.
risk of type 2 diabetes, and to identify a panel of the most predictive metabolic
markers.
combinations that provide added value in predicting the future incidence of type
learning models and marker panels was evaluated using repeated nested
9 year follow-up period in the DESIR (Data from an Epidemiological Study on the
diabetes (area under the receiver operating characteristic curve, AUC = 0.77)
significantly better than the reference model based on clinical risk factors
alone (AUC = 0.68; DeLong's p = 0.0009). The panel of metabolic markers selected
X-12063 and X-13435, which showed added value in predicting progression to type 2
diabetes when combined with known biomarkers such as glucose, mannose and
DOI: 10.1007/s00125-017-4325-0
PMCID: PMC5552834
The Eatwell Guide: Modelling the Health Implications of Incorporating New Sugar
Author information:
(1)Centre for Health Policy, School of Population and Global Health, The
changes on cardiovascular disease, diabetes and cancers over the lifetime of the
RESULTS: Changing the average diet to that recommended in the new Eatwell Guide,
without increasing total energy intake, could increase average life expectancy by
5.4 months (95% uncertainty interval: 4.7 to 6.2) for men and 4.0 months (3.4 to
4.6) for women; and avert 17.9 million (17.6 to 18.2) DALYs over the lifetime of
the current population. A large proportion of the health benefits are from
prevented in men and 340,000 (310,000 to 370,000) new cases prevented in women,
over the next ten years. Prevention of cardiovascular diseases and colorectal
cancer is also large. However, if the diet recommended in the new Eatwell Guide
in body mass index), around half the potential improvements in population health
will not be realised.
Guide, which include eating more fruits and vegetables and less red and processed
meats and dairy products, are large. However, the potential population health
DOI: 10.1371/journal.pone.0167859
PMCID: PMC5173361
Conflict of interest statement: PS, AK and MR received funding from Public Health
England during the conduct of the study. LC, PS and MR report grants from the
British Heart Foundation. This does not alter our adherence to PLOS ONE policies
eCollection 2018.
Effect of a Health Coach Intervention for the Management of Individuals With Type
Chapman A(1)(2)(3), Browning CJ(3)(4), Enticott JC(5)(6), Yang H(3)(5), Liu S(7),
Author information:
(1)School of Nursing and Midwifery and Centre for Quality and Patient Safety
(5)School of Primary and Allied Health Care, Monash University, Notting Hill,
VIC, Australia.
for Cancer Prevention and Control, Peking University Cancer Hospital and
China.
Aim: To determine the effect of a health coach intervention for the management of
of patients with type 2 diabetes mellitus (T2DM), compared with usual care.
Methods: This pragmatic cluster RCT was conducted in the Fengtai district of
Beijing from August 2011 to December 2013. Forty-one community health stations
Control participants received usual care according to the Chinese Guideline for
usual care. Medical and pathology fees were waived for both groups. Outcome
assessment was performed at baseline, 6, 12, and 18-months. The primary outcome
treatment effect was found at 18-months for HbA1c (adj. difference -0.07, 95% CI
change -3.65, 95% CI -3.92 to -3.37; control: mean change -3.38, 95% CI -3.67 to
(https://doi.org/10.1186/ISRCTN01010526).
DOI: 10.3389/fpubh.2018.00252
PMCID: PMC6156528
PMID: 30283767
Author information:
Oulu, Finland.
(4)Center for Life Course Epidemiology and Systems Medicine, Faculty of Medicine,
(5)Oulu University Hospital, Unit of General Practice, and Health Center of Oulu,
Oulu, Finland.
Karl-Heinz.Herzig@oulu.fi.
(T2D) subjects. 570 subjects from the 1945 Oulu birth cohort were included in the
glucose tolerance test was performed and LDL and HDL cholesterol analyzed. PA was
registered daily with a wrist-worn acceleration meter for two weeks. (cf)PWV
values in subjects with impaired glucose metabolism (IGM) and T2D were higher
than in normal glycemic subjects (P < 0.001). PA, fasting and 2 h glucose and
HbA1c correlated significantly with (cf)PWV, but HDL or LDL cholesterol did not.
The 2 h glucose, heart rate and alcohol consumption in T2D subjects had
independent effects on (cf)PWV in multiple regression analysis. T2D and IGM were
additional effect on (cf)PWV. Subjects walking more than 10 000 steps/day had
0.2 m/s lower (cf)PWV than those walking less than 6000 steps/day. Presence of
T2D, elevated heart rate and alcohol consumption in males were associated with
DOI: 10.1038/s41598-018-25755-4
PMCID: PMC5966452
PMID: 29795274
Effect of yoga and aerobics exercise on sleep quality in women with Type 2
Author information:
OBJECTIVE: The aim of this study was investigating the effect of 12 weeks of yoga
and aerobic exercise (running on a treadmill) on the sleep quality in women with
Type 2 diabetes.
MATERIALS AND METHODS: 39 diabetic women were selected from Semnan city with the
BMI of 29.64±5.00 kg/m2 who had a background of diabetes for 6.46±2.69 years.
They were then randomly divided into yoga exercise (n=15), aerobic exercise
(n=13), and control group (n=11). The exercise program was performed for 12
weeks, three sessions per each week. In order to measure the sleep quality, the
Pittsburgh Sleep Quality Index (PSQI) was used. The data were analyzed by
RESULTS: Overall score of sleep quality improved after six (p=0.001) and 12
(p=0.001) weeks of yoga exercise. Also, significant effect was observed after 6
weeks of aerobic exercise (p=0.039). However, the positive effect was diminished
improving the sleep quality in comparison with the same course of aerobic
exercise in women suffering from diabetes Type 2. Thus, yoga exercise can be
DOI: 10.5935/1984-0063.20170012
PMCID: PMC5612039
PMID: 28966742
Feb 7.
Effectiveness and Safety of a Novel Care Model for the Management of Type 2
Hallberg SJ(1)(2), McKenzie AL(3), Williams PT(4), Bhanpuri NH(2), Peters AL(5),
Campbell WW(6), Hazbun TL(1), Volk BM(2), McCarter JP(2)(7), Phinney SD(2), Volek
JS(2)(8).
Author information:
IN, USA.
USA.
MO, USA.
(8)Department of Human Sciences, The Ohio State University, Columbus, OH, USA.
Erratum in
patients with type 2 diabetes (T2D) but necessitates prompt medication changes.
Therefore, we assessed the effectiveness and safety of a novel care model
feedback combined with the metabolic approach of nutritional ketosis for T2D
management.
1-year study of this continuous care intervention (CCI) and usual care (UC).
use. Secondary outcomes included fasting serum glucose and insulin, HOMA-IR,
blood lipids and lipoproteins, liver and kidney function markers, and
RESULTS: 349 adults with T2D enrolled: CCI: n = 262 [mean (SD); 54 (8) years,
116.5 (25.9) kg, 40.4 (8.8) kg m2, 92% obese, 88% prescribed T2D medication]; UC:
n = 87 (52 (10) years, 105.6 (22.15) kg, 36.72 (7.26) kg m2, 82% obese, 87%
prescribed T2D medication]. 218 participants (83%) remained enrolled in the CCI
declined from 59.6 ± 1.0 to 45.2 ± 0.8 mmol mol-1 (7.6 ± 0.09% to 6.3 ± 0.07%,
P < 1.0 × 10-16), weight declined 13.8 ± 0.71 kg (P < 1.0 × 10-16), and T2D
29.7 ± 3.0% (P < 1.0 × 10-16). Insulin therapy was reduced or eliminated in 94%
were attributed to the CCI. Additional CCI 1-year effects were HOMA-IR - 55%
(P < 1.0 × 10-16), HDL-cholesterol + 18% (P < 1.0 × 10-16), and LDL-cholesterol
+ 10% (P = 5.1 × 10-5); serum creatinine and liver enzymes (ALT, AST, and ALP)
prescription at 1 year.
remote care model can support adults with T2D to safely improve HbA1c, weight,
DOI: 10.1007/s13300-018-0373-9
PMCID: PMC6104272
PMID: 29417495
eCollection 2018.
Author information:
prescribed diets.
Objectives: The purpose of the present study was to investigate the effectiveness
behaviors as well as levels of fasting blood sugar (FBS) and glycated hemoglobin
(HbA1c) in patients with T2D referring to diabetes clinics and healthcare centers
Methods: A total number of 145 patients were recruited in this clinical trial and
concerns, and discomforts associated with diabetic diet, as well as the valid and
required data before and 3 months after the completion of the educational
educational program for eight sessions but the individuals in the control group
only received routine services. Data analysis was also conducted using the SPSS
Results: The findings revealed that the mean scores of the sub-groups of
nutritional perceptions and beliefs (but not exaggerated ones) in the patients
assigned to the intervention group were significantly higher than those in the
control group after 3 months (p = 0.001). As well, the mean scores of the
levels of fasting blood sugar (FBS) and glycated hemoglobin (HbA1c) in the
Conclusion: The results of this study shed light on the importance of the
DOI: 10.1186/s13098-018-0368-8
PMCID: PMC6122479
PMID: 30186372
106. J Diabetes Res. 2017;2017:5282343. doi: 10.1155/2017/5282343. Epub 2017 Aug 24.
Suh S(1), Song SO(2), Kim JH(3), Cho H(4), Lee WJ(5), Lee BW(6).
Author information:
Korea.
Korea.
target (HbA1c) of ≤7.0% at 24 weeks. In total, 4303 patients were included in the
analysis; of these, 2087 patients were eligible. The mean patient age was
receiving care at the hospital versus clinic (67.95% versus 52.33%), and
0.0001), baseline HbA1c (P < 0.0001), and DC type (P = 0.0103) had significant
effective treatment option for patients with T2DM in clinical practice settings
in Korea.
DOI: 10.1155/2017/5282343
PMCID: PMC5613692
eCollection 2018.
The effects of an acute exercise bout on GH and IGF-1 in prediabetic and healthy
Author information:
(1)University of North Carolina at Greensboro, Greensboro, NC, United States of
America.
America.
likely to become diabetic than other ethnic groups. Over the long-term, metabolic
hormone (GH) and insulin-like growth factor-1 (IGF-1). Considering the limited
101.8±1.3 mg/dl) and 5 CON (age = 31±9.4 yr, BMI = 29.4±5.2, FBG = 82.8±9.7
mg/dl)] had blood drawn for RNA isolation prior to exercise (Pre), immediately
(Post-6), and 24-hours post (Post-24). Isolation of mRNA from PBMCs was performed
using ficoll separation, while the profiling of mRNA expression was performed
using Illumina beadchip arrays with standard protocols. Scan results were
and IGF-1 protein levels were also assessed in each sample. To address issues of
RESULTS: Group differences for GH2 variant 2 (p = 0.070) and GH2 variant 3 (p =
0.059) were coupled with significant alterations in IGF-1 mRNA over time (p =
0.024). A significant interaction between group and time was observed for GHRH
DOI: 10.1371/journal.pone.0191331
PMCID: PMC5774763
Altug HA(1), Tatli U(2), Coskun AT(1), Erdogan Ö(3), Özkan A(1), Sencimen M(1),
Kürkçü M(2).
Author information:
Zealand rabbits through IV injection of alloxan. After the state of diabetes had
been confirmed, one dental implant was placed in the metaphysical region of each
animal's tibia. After the implants' placements, the animals were divided into two
groups. Half of the animals underwent HBO treatment, while the other group did
not receive HBO treatment and served as the control group. The animals were
euthanized at the 4th and 8th weeks. The osseointegration of the implants were
RESULTS: The Bone Implant Contact (BIC) values were significantly higher in the
HBO group than in the control group at the 4th week. There was no difference in
the BIC values between the groups at the 8th week. There was no significant
difference in the RFA scores between the groups both at the 4th and 8th weeks
DOI: 10.1590/1678-7757-2018-0083
PMCID: PMC6025889
109. Int J Mol Sci. 2018 Apr 10;19(4). pii: E1132. doi: 10.3390/ijms19041132.
Csepanyi E(1)(2), Czompa A(3), Szabados-Furjesi P(4)(5), Lekli I(6), Balla J(7),
Author information:
potential raw materials for drug development. One of the most studied compounds
cardiovascular effects of BC, however, all these results are controversial. There
well. In this study, we investigated the effects of long-term, low- and high-dose
diabetic fatty (ZDF) rats. The animals were treated with various daily doses of
BC for 4 weeks and then hearts were isolated and subjected to 30 min of global
ischemia (ISA) followed by 120 min of reperfusion (REP). Blood glucose levels
were measured before, after two weeks, and at the end of the treatment. In
isolated hearts, the myocardial function was registered. At the end of the
reperfusion period, the infarct size (IS) and heme oxygenase-1 (HO-1) expression
were measured. The results showed that a low dose of BC treatment significantly
DOI: 10.3390/ijms19041132
PMCID: PMC5979408
Imamura F(1), Micha R(2), Wu JH(3), de Oliveira Otto MC(4), Otite FO(5), Abioye
(3)George Institute for Global Health, The University of Sydney, Sydney Medical
States of America.
homeostasis remain controversial and may vary by the clinical measures examined.
glucose-insulin homeostasis.
insulin sensitivity, and insulin secretion in adults aged ≥18 years. We excluded
supplements rather than meals. Studies were reviewed and data extracted
independently in duplicate. Among 6,124 abstracts, 102 trials, including 239 diet
dietary fibre. Replacing 5% energy from carbohydrate with SFA had no significant
effect on fasting glucose (+0.02 mmol/L, 95% CI = -0.01, +0.04; n trials = 99),
but lowered fasting insulin (-1.1 pmol/L; -1.7, -0.5; n = 90). Replacing
post-challenge insulin (-20.3 pmol/L; -32.2, -8.4; n = 11), and homeostasis model
-0.05) and fasting insulin (-1.6 pmol/L; -2.8, -0.4). Replacing SFA with PUFA
index). Limitations included a small number of trials for some outcomes and
favourable effects were seen with PUFA, which was linked to improved glycaemia,
DOI: 10.1371/journal.pmed.1002087
PMCID: PMC4951141
2018.
The Effects of Sleeve Gastrectomy on Glucose Metabolism and Glucagon-Like Peptide
1 in Goto-Kakizaki Rats.
Li L(1)(2), Wang X(2), Bai L(2), Yu H(1)(2), Huang Z(1)(3), Huang A(4), Luo
Author information:
rats.
Methods: GK rats were randomly assigned to one of three groups: SG, SG pair-fed
intake, body weight, blood glucose, GLP-1 and insulin levels, and GLP-1
Results: The SG rats exhibited lower postoperative food intake, body weight, and
fasting glucose than did the control rats (P < 0.05). SG significantly improved
glucose and insulin tolerance (P < 0.05). Plasma GLP-1 levels were higher in SG
rats than in control or PF-sham rats in the oral glucose tolerance test (OGTT) (P
< 0.05). Blood glucose levels expressed as a percentage of baseline were higher
in SG rats than in control rats after exendin (9-39) administration (P < 0.05).
The levels of GLP-1 expression in the jejunum and ileum were higher in SG rats
via increased GLP-1 expression in the mucosa of the jejunum and/or ileum.
DOI: 10.1155/2018/1082561
PMCID: PMC5835276
112. Adv Ther. 2018 Mar;35(3):367-381. doi: 10.1007/s12325-018-0668-2. Epub 2018 Feb
27.
Efficacy and Safety of GPR119 Agonist DS-8500a in Japanese Patients with Type 2
Yamada Y(1), Terauchi Y(2), Watada H(3), Nakatsuka Y(4), Shiosakai K(5), Washio
Author information:
Japan.
(5)Biostatistics & Data Management, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi,
the efficacy and safety of the GPR119 agonist DS-8500a with placebo and
patients aged ≥ 20 years with T2DM and hemoglobin A1c (HbA1c) ≥ 7.0% and < 10.0%
50 mg once daily for 12 weeks. The primary efficacy endpoint was change in HbA1c
from baseline to week 12. Secondary endpoints included change in fasting plasma
glucose (FPG), glucose AUC0-3h during a meal tolerance test, 2-hour postprandial
(p = 0.0001), and - 0.44% (p < 0.0001) in the 25-mg, 50-mg, and 75-mg groups,
respectively. At 50- and 75-mg doses, DS-8500a significantly lowered FPG, glucose
AUC0-3h, and 2hr-PPG compared with placebo. The glucose-lowering effect was
maintained up to 12 weeks. DS-8500a did not lower any of the above parameters to
DOI: 10.1007/s12325-018-0668-2
PMCID: PMC5859088
PMID: 29488152
2018.
Vargas-Uricoechea H(1).
Author information:
To achieve good metabolic control in diabetes and maintain it in the long term, a
The need for insulin depends upon the balance between insulin secretion and
control their blood glucose levels; yet, many people with type 2 diabetes
mellitus will also eventually require insulin therapy, due to the progressive
basal insulin therapy (such as insulin glargine, degludec, and detemir), each
having sufficient pharmacodynamic and pharmacokinetic profiles to afford lower
formulation was developed to have a flatter and more extended time-action profile
than the original glargine-100, and these characteristics may translate into more
stable and sustained glycemic control over a 24 h dosing interval. The objective
clinical efficacy and safety of glargine-300 versus glargine-100 from the EDITION
clinical trial program, in patients with type 1 and type 2 diabetes mellitus.
DOI: 10.1155/2018/2052101
PMCID: PMC5830021
114. Diabetes Metab Syndr Obes. 2016 Nov 4;9:381-390. eCollection 2016.
diabetes self-management.
Rollo ME(1), Aguiar EJ(2), Williams RL(1), Wynne K(3), Kriss M(3), Callister
Author information:
NSW, Australia.
intake and physical activity are key diabetes self-management (DSM) behaviors
covered include those widely used for DSM, such as web-based programs and mobile
virtual and augmented reality, video games, computer vision for dietary
carbohydrate monitoring, and wearable devices are provided. The challenges to,
and facilitators for, the use of eHealth technologies in DSM are discussed.
and suggestions for future research to enhance nutrition and physical activity
DOI: 10.2147/DMSO.S95247
PMCID: PMC5104301
PMID: 27853384
this work.
115. BMJ Open Diabetes Res Care. 2017 Jul 19;5(1):e000401. doi:
Author information:
study.
administrative and the 3 (coast, highlands and jungle) natural regions across the
country, from both sexes, aged 25+ years at baseline, enrolled in 2010-2012, were
followed for 3.8 years. New diabetes cases were defined as fasting blood glucose
weighted cumulative incidence of diabetes was 7.2% while the weighted incidence
rate was estimated at 19.5 (95% CI 13.9 to 28.3) new cases per 1000 person-years.
CONCLUSION: Our results confirm that the incidence of diabetes in Peru is among
the highest reported globally. The fast economic growth in the last 20 years,
high overweight and obesity rates may have triggered this phenomenon.
DOI: 10.1136/bmjdrc-2017-000401
PMCID: PMC5574423
PMID: 28878935
from Sanofi for participation in this study. He also provided ad hoc consultancy
Diabetes Mellitus.
Author information:
in patients with type 2 diabetes mellitus (T2DM). MATERIAL AND METHODS The levels
analyses were performed. RESULTS Serum β2-GPI/oxLDL complexes and oxLDL levels
and cardioembolic infarction (1.00±0.23 U/ml). In all patients with T2DM, the
analysis indicated that elevated b2-GPI/oxLDL and oxLDL levels were independently
PMCID: PMC5841189
Chung J(1).
Author information:
(1)1 Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey
Diabetes mellitus (DM) is a rapidly worsening global epidemic over the last
increase in lesions in the tibial vessels. These patients are also afflicted with
minimally invasive tools and techniques have been developed to improve the blood
common femoral artery (CFA) in a retrograde fashion, is now also frequently being
the tibial, pedal, tarsal, or calf collateral vessels is also being utilized to
provide a route through which wires, catheters, balloons and stents may be
placed. Wires have evolved to have a variety of diameters, materials and coatings
traverse blockages in the arteries. When catheters and wires fail to traverse the
lesion, newer chronic total occlusion (CTO) devices have been developed to aid in
the placement of a wire across the offending lesions. Due to medial calcification
associated with DM, atherectomy devices have been developed to debulk the
atherosclerotic plaque within the vessel. High pressure balloon angioplasty with
(DCBs) and drug-eluting stents (DESs) now being frequently used to prevent
DOI: 10.1177/1932296817702169
PMCID: PMC5950991
diabetes.
Author information:
hubert.kolb@uni-duesseldorf.de.
hubert.kolb@uni-duesseldorf.de.
populations, are generally believed to account for the rapid global increase in
exposure to noise or fine dust, short or disturbed sleep, smoking, stress and
increase in body mass index. Since loss of β-cell function is the ultimate cause
DOI: 10.1186/s12916-017-0901-x
PMCID: PMC5516328
119. Nanomaterials (Basel). 2017 Feb 15;7(2). pii: E39. doi: 10.3390/nano7020039.
Author information:
rjchung@ntut.edu.tw.
dai20020223@gmail.com.
terrypntut@gmail.com.
carbon-coated tin sulfide (SnS) assembled on a glass carbon electrode (GCE) was
developed, and its direct electrochemistry was investigated. The carbon coated
SnS (C-SnS) nanoparticle was prepared through a simple two-step process, using
hydrothermal and chemical vapor deposition methods. The large reactive surface
electrode surface. The structure and sensor ability of the proposed GOx/C-SnS
DOI: 10.3390/nano7020039
PMCID: PMC5333024
PMID: 28336872
120. J Cell Mol Med. 2018 Mar;22(3):1720-1732. doi: 10.1111/jcmm.13453. Epub 2018 Jan
4.
Luo JQ(1)(2), Ren H(3)(4), Liu MZ(1)(2), Fang PF(1)(2), Xiang DX(1)(2).
Author information:
China.
Many studies have examined the associations between paraoxonase-1 (PON1) genetic
polymorphisms (Q192R, rs662 and L55M, rs854560) and the susceptibility to type 2
diabetes mellitus (T2DM) across different ethnic populations. However, the
meta-analysis to clarify the association of the two PON1 variants with T2DM risk.
We carried out a systematic search of PubMed, Embase, CNKI and Wanfang databases
for studies published before June 2017. The pooled odds ratios (ORs) for the
including 34 and 16 studies were identified for the PON1 Q192R (rs662) and L55M
192R allele was a susceptible factor of T2DM in the South or East Asian
population (OR > 1, P < 0.05) but represented a protective factor of T2DM in
model. With regard to the PON1 L55M polymorphism, significant protective effects
of the 55M allele on T2DM under the heterozygous (OR = 0.77, 95% CI = 0.61-0.97)
and dominant (OR = 0.80, 95% CI = 0.65-0.99) genetic models were found in the
meta-analysis, our results firmly indicated that distinct effects of PON1 genetic
© 2018 The Authors. Journal of Cellular and Molecular Medicine published by John
Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.
DOI: 10.1111/jcmm.13453
PMCID: PMC5824408
PMID: 29314660
121. BMJ Open Diabetes Res Care. 2016 Aug 18;4(1):e000275. doi:
Gupta R(1), Lodha S(1), Sharma KK(2), Sharma SK(3), Gupta S(4), Asirvatham AJ(5),
Mahanta BN(6), Maheshwari A(7), Sharma DC(8), Meenawat AS(9), Khedar RS(1).
Author information:
Eternal Heart Care Centre and Research Institute, Mount Sinai New York Affiliate
India.
Maharashtra , India.
India.
Pradesh , India.
India.
with diabetes for reducing coronary risk. Use of statins in patients with type 2
clinical details were obtained and prescriptions were audited for various
medications with a focus on statins. Details of type of statin and dosage form
(low, moderate, and high) were obtained. Patients were divided into categories
based on presence of cardiovascular risk into low (no risk factors, n=1506),
medium (≥1 risk factor, n=5425), and high (with vascular disease, n=1769).
RESULTS: Prescription details were available in 8699 (men 5292, women 3407).
Statins were prescribed in 55.2% and fibrates in 9.2%. Statin prescription was
74.1%, rosuvastatin in 29.2%, and others in 3.0%. Statin prescriptions were lower
in women (52.1%) versus men (57.2%; p<0.001) and in patients aged <40 years
(34.3%), versus those aged 40-49 (49.7%), 50-59 (60.1%), and ≥60 years (62.2%;
p<0.001). Low-dose statins were prescribed in 1.9%, moderate dose in 85.4%, and
high dose in 12.7%. Statin prescriptions were greater in the high-risk group
(58.0%) compared with those in the medium-risk (53.8%) and low-risk (56.8%)
DOI: 10.1136/bmjdrc-2016-000275
PMCID: PMC5013346
PMID: 27648292
80 years and over: population-based cohort study using electronic health records.
(1)Department of Primary Care and Public Health Sciences, King's College London,
3rd Floor Addison House, Guy's Campus, London, SE1 1UL, UK.
nisha.hazra@kcl.ac.uk.
(2)Department of Primary Care and Public Health Sciences, King's College London,
3rd Floor Addison House, Guy's Campus, London, SE1 1UL, UK.
(3)NIHR Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust,
Erratum in
population aged 80 years and over in the United Kingdom from 1990 to 2014, using
participants, with stratified sampling by five-year age group up to 100 years and
individuals aged 80 to 95 years. A lower risk of coronary heart disease (HR 0.54,
95% confidence interval [CI]: 0.50-0.58), stroke (0.83, 0.76-0.90) and chronic
over-80s, are consistent with the "fourth stage" of epidemiologic transition, but
DOI: 10.1186/s12963-017-0136-2
PMCID: PMC5429583
2018 Aug 9.
Excess risk of hospitalisation for heart failure among people with type 2
diabetes.
Rosengren A(1)(2), Edqvist J(3)(4), Rawshani A(3), Sattar N(5), Franzén S(6),
Author information:
Sweden. Annika.Rosengren@gu.se.
Annika.Rosengren@gu.se.
Sweden.
Gothenburg, Sweden.
but age-specific data are sparse. We aimed to determine excess risk of heart
failure, based on age, glycaemic control and kidney function in comparison with
Diabetes Registry 1998-2012 (n = 266,305) were compared with age-, sex- and
62.0 years, 45.3% women) and 1,323,504 control individuals. Of the individuals
with type 2 diabetes and control individuals, 18,715 (7.0%) and 50,157 (3.8%)
individuals with diabetes with those in the control group, men and women with
type 2 diabetes who were younger than 55 years of age had HRs for hospitalisation
for heart failure of 2.07 (95% CI 1.73, 2.48) and 4.59 (95% CI 3.50, 6.02),
function were all associated with increased excess risk of heart failure in those
with type 2 diabetes compared with the control group. However, people with
diabetes who were ≥75 years and without albuminuria or with good glycaemic
control (HbA1c ≤52 mmol/mol [≤6.9%]) had a similar risk of hospitalisation for
CONCLUSIONS/INTERPRETATION: Men and women aged <55 years with type 2 diabetes are
at markedly elevated excess risk of heart failure. The excess risk declined with
age, but persisted even with good glycaemic control. However, among those who
were 75 years and older, diabetic individuals with well controlled glucose levels
or without albuminuria had a risk of heart failure that was on a par with
DOI: 10.1007/s00125-018-4700-5
PMCID: PMC6182656
PMID: 30094466
124. Oxid Med Cell Longev. 2017;2017:9410954. doi: 10.1155/2017/9410954. Epub 2017 Jan
12.
Sakurai T(1), Ogasawara J(1), Shirato K(1), Izawa T(2), Oh-Ishi S(3), Ishibashi
Author information:
Chest Diseases and Severe Motor and Intellectual Disabilities, Terunuma 825,
Tokyo, Japan.
Obesity-induced inflammatory changes in white adipose tissue (WAT), which caused
that WAT generates reactive oxygen species (ROS), and the enhanced production of
ROS in obese WAT has been closely associated with the dysregulated expression of
adipokines in WAT. Therefore, the reduction in excess WAT and oxidative stress
only brings about a decrease in WAT mass but also attenuates obesity-induced
indicate that TR affects the generation of oxidative stress in WAT. This review
DOI: 10.1155/2017/9410954
PMCID: PMC5266865
eCollection 2017.
meta-analysis.
Perú.
function, may detect subjects with type 2 diabetes mellitus (T2DM). The aim of
the study was to conduct a systematic review and meta-analysis including studies
assessing the performance of the EZSCAN for detecting cases of undiagnosed T2DM.
diagnostic accuracy and performance results assessing EZSCAN for detecting cases
of undiagnosed T2DM. OVID (Medline, Embase, Global Health), CINAHL and SCOPUS
databases, plus secondary resources, were searched until March 29, 2017. The
following keywords were utilized for the systematic searching: type 2 diabetes
quality of the data using the Revised Version of the Quality Assessment of
variances. Heterogeneity was also assessed using the I2 measure. Four studies (n
= 7,720) were included, three of them used oral glucose tolerance test as the
model, summary sensitivity was 72.0% (95%CI: 60.0%- 83.0%), whereas specificity
was 56.0% (95%CI: 38.0%- 74.0%). Studies were very heterogeneous (I2 for
sensitivity: 79.2% and for specificity: 99.1%) regarding the inclusion criteria
selection bias was detected in most of the studies included. More studies are
needed to evaluate the performance of the EZSCAN for undiagnosed T2DM screening,
DOI: 10.1371/journal.pone.0187297
PMCID: PMC5662214
eCollection 2017.
equations modeling.
Author information:
Tehran, Iran.
METHODS: This study has been conducted within the framework of the Tehran Lipid
and Glucose Study (TLGS) between 2008-2010. A total of 5568 (55.4% female)
non-diabetic adults, aged ≥20 years, selected from among participants of the
TLGS, were recruited for the study. Data on socio-behavioral factors, family
p<0.001). Body mass index (BMI) and triglycerides (TG) in both sexes and
hypertension and high density lipoprotein only in women, were directly associated
with pre-diabetes (p<0.05). Poor diet in women was the only behavioral factor
directly associated with pre-diabetes (p<0.05). Age in both sexes and education,
only in women, were directly associated with pre-diabetes. In both genders, age,
marital status, education, employment, poor diet and leisure time physical
risk factors.
were TG in women and BMI in men, which need to be prioritized in health policies
DOI: 10.1371/journal.pone.0188898
PMCID: PMC5720750
Factors associated with self-care practice among adult diabetes patients in West
Author information:
of Health Science, Addis Ababa University, P.O. Box: 4412, Addis Ababa, Ethiopia.
debegela@gmail.com.
of Health Science, Addis Ababa University, P.O. Box: 9083, Addis Ababa, Ethiopia.
show that few diabetes patients practice the recommended self-care in Ethiopia.
The aim of this study was to assess factors associated with self-care practice
among adult diabetes patients in public hospitals of West Shoa Zone, Oromia
42.9 ± 14.6 years, 54.1% male) completed the survey in Afan Oromo and Amharic
data. Descriptive and logistic regression analyses were conducted using SPSS
version 21.
RESULTS: The mean score for diabetes self-care was 39.8 ± 9.5 and 45.5% of the
and longer duration of diabetes (AOR = 5.55, 95% CI = 2.29, 13.44) were important
CONCLUSION: The diabetes education programs should use strategies that enhance
recent diabetes diagnosis need special attention as they may relatively lack
DOI: 10.1186/s12913-018-3448-4
PMCID: PMC6154910
PMID: 30249246
Fatty Acid Profiles of Various Vegetable Oils and the Association between the Use
of Palm Oil vs. Peanut Oil and Risk Factors for Non-Communicable Diseases in
Aung WP(1)(2), Bjertness E(3), Htet AS(4)(5), Stigum H(6), Chongsuvivatwong V(7),
Author information:
waiphyoaung77@gmail.com.
espen.bjertness@medisin.uio.no.
aungsh@gmail.com.
(5)International Relations Division, Ministry of Health and Sports, Nay Pyi Taw
hein.stigum@medisin.uio.no.
cvirasak@gmail.com.
m.k.kjollesdal@medisin.uio.no.
The majority of vegetable oils used in food preparation in Myanmar are imported
and sold non-branded. Little is known about their fatty acid (FA) content. We
Yangon region, and the association between the use of palm oil vs. peanut oil and
risk factors for non-communicable disease (NCD). A multistage cluster survey was
conducted in 2016, and 128 oil samples from 114 households were collected. Data
on NCD risk factors were obtained from a household-based survey in the same
region, between 2013 and 2014. The oils most commonly sampled were non-branded
peanut oil (43%) and non-branded palm oil (19%). Non-branded palm oil had a
significantly higher content of saturated fatty acids (36.1 g/100 g) and a lower
content of polyunsaturated fatty acids (9.3 g/100 g) than branded palm oil. No
significant differences were observed regarding peanut oil. Among men, palm oil
users had significantly lower mean fasting plasma glucose levels and mean BMI
than peanut oil users. Among women, palm oil users had significantly higher mean
diastolic blood pressure, and higher mean levels of total cholesterol and
DOI: 10.3390/nu10091193
PMCID: PMC6163161
PMID: 30200403
Author information:
(2)Howard Hughes Medical Institute, Salk Institute for Biological Studies, 10010
for the development of insulin resistance, type 2 diabetes mellitus (T2DM) and
modification, and includes oral medications and insulin therapy to compensate for
progressive β-cell failure. However, current pharmaceutical options for T2DM are
limited in that they do not maintain stable, durable glucose control without the
with adverse effects, which range from hypoglycaemia to weight gain or bone loss.
Unexpectedly, fibroblast growth factor 1 (FGF1) and its low mitogenic variants
FGF1 can lower glucose to normal levels within hours, without the risk of
DOI: 10.1038/nrendo.2017.78
PMCID: PMC5839646
130. BMC Complement Altern Med. 2018 Oct 19;18(1):282. doi: 10.1186/s12906-018-2346-y.
Elbashir SMI(1), Devkota HP(2)(3), Wada M(4), Kishimoto N(5), Moriuchi M(6),
Author information:
Japan.
Japan. devkotah@kumamoto-u.ac.jp.
devkotah@kumamoto-u.ac.jp.
worldwide. In Sudan, there are a variety of plant species used traditionally for
the treatment of diabetes, obesity and other symptoms which need to be validated
through scientific studies for their claimed traditional uses. Therefore, in the
current study, the free radical scavenging activity, α-glucosidase inhibitory and
assays. Moreover, the cytotoxicity and genotoxicity were assessed for the
METHODS: Eighteen plants were selected on the basis of their traditional uses and
extracted with 70% ethanol and water to obtain thirty-six extracts. The obtained
and pancreatic lipase inhibitory assays. Furthermore, the active plant extracts
were investigated for their cytotoxicity and genotoxicity on HeLa cell line using
spina-christi, Abrus precatorius, and Geigeria alata along with the 70% ethanol
activity. In general, 70% ethanol extracts were more potent compared to water
extracts with exception of Cordia sinensis and Cymbopogon proximus, for which
water extracts also showed potent enzyme inhibitory activity. Similarly, water
activity against pancreatic lipase enzyme. Some of the extracts also showed
bioactivities.
DOI: 10.1186/s12906-018-2346-y
PMCID: PMC6194694
PMID: 30340582
Frequent pain in older people with and without diabetes - Finnish community based
study.
Author information:
Finland.
BACKGROUND: The association between pain and diabetes in older people has been
largely unexplored. The aim of this survey was to analyze the prevalence and
characteristics of pain among Finnish men and women 65 or older with and without
METHODS: All home-dwelling persons 65 years or older with diabetes (N = 527) and
age and gender matched controls (N = 890) were identified from electronic patient
records. Frequent pain was regarded as any pain experienced more often than once
a week, and it was divided into pain experienced several times a week but not
daily and pain experienced daily or continuously. The Numeric Rating Scale (0-10)
(NRS) was used to assess the intensity and interference of the pain.
RESULTS: The number of subjects who returned the questionnaire was 1084 (76.5%).
The prevalence of frequent pain in the preceding week was 50% among women without
diabetes and 63% among women with diabetes (adjusted, p = 0.22). In men, the
corresponding proportions were 42% without diabetes and 47% with diabetes
comorbidities were associated with pain experienced more often than once a week
and with daily pain. Diabetes was not associated with pain intensity or pain
CONCLUSIONS: Pain in older adults is associated with depressive symptoms and the
PMCID: PMC5856375
disease.
Author information:
Germany.
the role of the fructose component of high-sugar foods in driving CMS. The
systemic pathologies that cooperatively promote CMS and CVD, reference recent
conditions and discuss how this understanding is shaping preventive actions and
therapeutic approaches.
DOI: 10.1093/eurheartj/ehx518
PMID: 29020416
Owolabi MO(1), Yaria JO(2), Daivadanam M(3)(4), Makanjuola AI(2), Parker G(5),
Oldenburg B(6), Vedanthan R(7), Norris S(8), Oguntoye AR(2), Osundina MA(2),
Herasme O(7), Lakoh S(2), Ogunjimi LO(2), Abraham SE(2), Olowoyo P(9), Jenkins
C(10), Feng W(10), Bayona H(11), Mohan S(12), Joshi R(13), Webster R(13), Kengne
Lazo-Porras M(18), Bobrow K(19), Riddell MA(20), Makrilakis K(21), Manios Y(22),
Author information:
Colombia.
(13)The George Institute for Global Health, The University of New South Wales,
Sydney, Australia.
OBJECTIVE: The extent to which diabetes (DM) practice guidelines, often based on
HIC over the past decade to identify aspects that could be improved to facilitate
implementation.
RESEARCH DESIGN AND METHODS: Eligible guidelines were sought from online
were included. Each of the 54 eligible guidelines was assessed for compliance
only a few including patients (7%), payers (11%), and policy makers (18%) as
their target audiences. Compared with HIC guidelines, the spectrum of DM clinical
care addressed by LMIC guidelines was narrow. Most guidelines from the LMIC
complied with less than half of the IOM standards, with 12% of the LMIC
guidelines satisfying at least four IOM criteria as opposed to 60% of the HIC
DOI: 10.2337/dc17-1795
Author information:
(1)School of Biomedical Sciences, The Chinese University of Hong Kong Hong Kong,
China.
(2)School of Biomedical Sciences, The Chinese University of Hong Kong Hong Kong,
China; State Key Laboratory of Digestive Disease, The Chinese University of Hong
Liver cancer is the third most common cancer type and the second leading cause of
disparities in the incidence and the cumulative risk of liver cancer. A number of
fatty liver diseases (NAFLD) and ultimately liver cancer. The deregulation of fat
current standing on the gender differences in body fat compositions and their
emphasis on genetic, epigenetic and microRNA control. The potential roles of sex
DOI: 10.3389/fgene.2016.00168
PMCID: PMC5029146
PMID: 27703473
Author information:
Zanjan, Iran.
this study was to estimate general health status among Iranian diabetic patients
Short-Form-36 questionnaire.
METHODS: Searching the EMBASE, PubMed, ISI/Web of Sciences (WOS), MEDLINE via
Ovid, PsycoINFO, as well as Iranian databases (MagIran, Iranmedex, and SID) from
January 2000 to December 2017. The methodological quality of the studies was
evaluated using the "A Cochrane Risk of Bias Assessment Tool: for Non-Randomized
heterogeneity between studies, I2 test was used. Egger's regression test was used
RESULTS: Fourteen studies were retained in the final analysis. The mean general
health status using SF-36 in diabetic patients of Iran was 51.9 (95% CI: 48.64 to
53.54). The mean physical component summary was 52.92 [95% CI: 49.46-56.38],
while the mean mental component summary was 51.02 [95% CI: 46.87-55.16].
CONCLUSION: The findings of this study showed that general health status in
Iranian diabetic patients is low. Health policymakers should work to improve the
DOI: 10.1186/s12902-018-0262-2
PMCID: PMC5984362
Huang J(1), Rajapakse A(2), Xiong Y(2), Montani JP(1), Verrey F(3), Ming XF(1),
Yang Z(1).
Author information:
Switzerland.
of ZurichZurich, Switzerland.
anion and decreased NO production thereby endothelial dysfunction. Arg-II but not
damage associated with diet-induced obesity mouse model. Wild type (WT) C57BL/6
mice and mice deficient in Arg-II gene (Arg-II-/-) were fed with either a normal
chow (NC) or a high-fat-diet (HFD) for 14 weeks (starting at the age of 7 weeks)
HFD feeding also significantly augmented renal Arg-II expression and activity.
All the alterations in the kidney under HFD feeding were reduced in Arg-II-/-
immunoblotting were reduced in the HFD-fed Arg-II-/- mice, although there was no
significant difference in body weight and renal weight/body weight ratio between
DOI: 10.3389/fphys.2016.00560
PMCID: PMC5118905
PMID: 27920727
Xue A(1), Wu Y(1), Zhu Z(1), Zhang F(1), Kemper KE(1), Zheng Z(1)(2), Yengo L(1),
Author information:
51010, Estonia.
(4)Queensland Brain Institute, The University of Queensland, Brisbane,
identify 139 common and 4 rare variants associated with T2D, 42 of which (39
common and 3 rare variants) are independent of the known variants. Integration of
the gene expression data from blood (n = 14,115 and 2765) with the GWAS results
epigenomic annotation data highlight 3 genes (CAMK1D, TP53INP1, and ATP5G1) with
additional loci, proposes putative genetic regulatory mechanisms for T2D, and
DOI: 10.1038/s41467-018-04951-w
PMCID: PMC6063971
PMID: 30054458
Author information:
(1)Department of Global Health and Population, Harvard T.H. Chan School of Public
Germany.
(5)MRC/Wits Rural Public Health and Health Transitions Research Unit, School of
(6)Centre for Global Health, King's College London, London, United Kingdom.
(11)Center for Health Decision Science, Harvard T.H. Chan School of Public
India. Yet, evidence on the CVD risk of India's population is limited. To inform
health system planning and effective targeting of interventions, this study aimed
to determine how CVD risk-and the factors that determine risk-varies among states
characteristics.
METHODS AND FINDINGS: We used 2 large household surveys carried out between 2012
and 2014, which included a sample of 797,540 adults aged 30 to 74 years across
India. The main outcome variable was the predicted 10-year risk of a CVD event as
calculated with the Framingham risk score. The Harvard-NHANES, Globorisk, and
WHO-ISH scores were used in secondary analyses. CVD risk and the prevalence of
CVD risk factors were examined by state, rural-urban residence, age, sex,
household wealth, and education. Mean CVD risk varied from 13.2% (95% CI:
both positively associated with CVD risk. Similarly, household wealth quintile
and living in an urban area were positively associated with CVD risk among both
sexes, but the associations were stronger among women than men. Smoking was more
prevalent in poorer household wealth quintiles and in rural areas, whereas body
mass index, high blood glucose, and systolic blood pressure were positively
associated with household wealth and urban location. Men had a substantially
1.8% [95% CI: 1.7%-1.9%]) and mean systolic blood pressure (126.9 mm Hg [95% CI:
limitations of this analysis are the high proportion of missing values (27.1%) in
targeting of CVD programs to those most at risk and most in need. While the CVD
risk scores used have not been validated in South Asian populations, the patterns
of variation in CVD risk among the Indian population were similar across all 4
DOI: 10.1371/journal.pmed.1002581
PMCID: PMC6007838
PMID: 29920517
interests exist.
Global, regional, and national incidence, prevalence, and years lived with
disability for 310 diseases and injuries, 1990-2015: a systematic analysis for
Collaborators: Vos T, Allen C, Arora M, Barber RM, Bhutta ZA, Brown A, Carter A,
Casey DC, Charlson FJ, Chen AZ, Coggeshall M, Cornaby L, Dandona L, Dicker DJ,
Fullman N, Gething PW, Goldberg EM, Graetz N, Haagsma JA, Johnson CO, Kassebaum
NJ, Kawashima T, Kemmer L, Khalil IA, Kinfu Y, Kyu HH, Leung J, Liang X, Lim SS,
Lopez AD, Lozano R, Marczak L, Mensah GA, Mokdad AH, Naghavi M, Nguyen G, Nsoesie
E, Olsen H, Pigott DM, Pinho C, Rankin Z, Reinig N, Salomon JA, Sandar L, Smith
Adebiyi AO, Ademi Z, Adou AK, Afanvi KA, Agardh EE, Agarwal A, Kiadaliri AA,
Ahmadieh H, Ajala ON, Akinyemi RO, Akseer N, Al-Aly Z, Alam K, Alam NK, Aldhahri
SF, Alegretti MA, Alemu ZA, Alexander LT, Alhabib S, Ali R, Alkerwi A, Alla F,
Amberbir A, Amini H, Ammar W, Amrock SM, Andersen HH, Anderson GM, Anderson BO,
L, Barrero LH, Basu A, Bazargan-Hejazi S, Bell B, Bell ML, Bennett DA, Bensenor
IM, Benzian H, Berhane A, Bernabé E, Betsu BD, Beyene AS, Bhala N, Bhatt S,
Buchbinder R, Buckle GC, Butt ZA, Calabria B, Campos-Nonato IR, Campuzano JC,
Carabin H, Cárdenas R, Carpenter DO, Carrero JJ, Castañeda-Orjuela CA, Rivas JC,
Catalá-López F, Chang JC, Chiang PP, Chibueze CE, Chisumpa VH, Choi JJ, Chowdhury
R, Christensen H, Christopher DJ, Ciobanu LG, Cirillo M, Coates MM, Colquhoun SM,
Cooper C, Cortinovis M, Crump JA, Damtew SA, Dandona R, Daoud F, Dargan PI, das
Neves J, Davey G, Davis AC, Leo D, Degenhardt L, Del Gobbo LC, Dellavalle RP,
Diaz-Torné C, Ding EL, Driscoll TR, Duan L, Dubey M, Duncan BB, Ebrahimi H,
Ellenbogen RG, Elyazar I, Endres M, Endries AY, Ermakov SP, Eshrati B, Estep K,
Farid TA, Farinha CS, Faro A, Farvid MS, Farzadfar F, Feigin VL, Felson DT,
Fereshtehnejad SM, Fernandes JG, Fernandes JC, Fischer F, Fitchett JR, Foreman K,
Fowkes FG, Fox J, Franklin RC, Friedman J, Frostad J, Fürst T, Futran ND, Gabbe
B, Ganguly P, Gankpé FG, Gebre T, Gebrehiwot TT, Gebremedhin AT, Geleijnse JM,
Gessner BD, Gibney KB, Ginawi IA, Giref AZ, Giroud M, Gishu MD, Glaser E, Godwin
WW, Gomez-Dantes H, Gona P, Goodridge A, Gopalani SV, Gotay CC, Goto A, Gouda HN,
RA, Haile D, Hailu AD, Hailu GB, Halasa YA, Hamadeh RR, Hamidi S, Hammami M,
Hancock J, Handal AJ, Hankey GJ, Hao Y, Harb HL, Harikrishnan S, Haro JM,
Havmoeller R, Hay RJ, Heredia-Pi IB, Heydarpour P, Hoek HW, Horino M, Horita N,
Hosgood HD, Hoy DG, Htet AS, Huang H, Huang JJ, Huynh C, Iannarone M, Iburg KM,
Innos K, Inoue M, Iyer VJ, Jacobsen KH, Jahanmehr N, Jakovljevic MB, Javanbakht
M, Jayatilleke AU, Jee SH, Jeemon P, Jensen PN, Jiang Y, Jibat T, Jimenez-Corona
A, Jin Y, Jonas JB, Kabir Z, Kalkonde Y, Kamal R, Kan H, Karch A, Karema CK,
Kesavachandran CN, Khader YS, Khan AR, Khan EA, Khang YH, Khera S, Khoja TA,
Khubchandani J, Kieling C, Kim P, Kim CI, Kim D, Kim YJ, Kissoon N, Knibbs LD,
Knudsen AK, Kokubo Y, Kolte D, Kopec JA, Kosen S, Kotsakis GA, Koul PA, Koyanagi
A, Kravchenko M, Defo BK, Bicer BK, Kudom AA, Kuipers EJ, Kumar GA, Kutz M, Kwan
GF, Lal A, Lalloo R, Lallukka T, Lam H, Lam JO, Langan SM, Larsson A, Lavados PM,
BK, Lo WD, Logroscino G, Looker KJ, Lotufo PA, Lunevicius R, Lyons RA, Mackay MT,
Margolis DJ, Martinez-Raga J, Masiye F, Massano J, McGarvey ST, McGrath JJ, McKee
M, McMahon BJ, Meaney PA, Mehari A, Mejia-Rodriguez F, Mekonnen AB, Melaku YA,
Memiah P, Memish ZA, Mendoza W, Meretoja A, Meretoja TJ, Mhimbira FA, Miller TR,
Mills EJ, Mirarefin M, Mitchell PB, Mock CN, Mohammadi A, Mohammed S, Monasta L,
Mullany E, Mumford JE, Murdoch ME, Nachega JB, Nagel G, Naheed A, Naldi L, Nangia
V, Newton JN, Ng M, Ngalesoni FN, Nguyen QL, Nisar MI, Pete PM, Nolla JM, Norheim
OF, Norman RE, Norrving B, Nunes BP, Ogbo FA, Oh IH, Ohkubo T, Olivares PR,
Olusanya BO, Olusanya JO, Ortiz A, Osman M, Ota E, Pa M, Park EK, Parsaeian M, de
Azeredo Passos VM, Caicedo AJ, Patten SB, Patton GC, Pereira DM, Perez-Padilla R,
Perico N, Pesudovs K, Petzold M, Phillips MR, Piel FB, Pillay JD, Pishgar F,
Plass D, Platts-Mills JA, Polinder S, Pond CD, Popova S, Poulton RG, Pourmalek F,
Rahimi-Movaghar V, Rahman M, Rahman MH, Rahman SU, Rai RK, Rajsic S, Ram U, Rao
P, Refaat AH, Reitsma MB, Remuzzi G, Resnikoff S, Reynolds A, Ribeiro AL, Blancas
MJ, Roba HS, Rojas-Rueda D, Ronfani L, Roshandel G, Roth GA, Rothenbacher D, Roy
A, Sagar R, Sahathevan R, Sanabria JR, Sanchez-Niño MD, Santos IS, Santos JV,
Schmidt MI, Schneider IJ, Schöttker B, Schwebel DC, Scott JG, Seedat S, Sepanlou
SG, Servan-Mori EE, Shackelford KA, Shaheen A, Shaikh MA, Sharma R, Sharma U,
Shen J, Shepard DS, Sheth KN, Shibuya K, Shin MJ, Shiri R, Shiue I, Shrime MG,
Sigfusdottir ID, Silva DA, Silveira DG, Singh A, Singh JA, Singh OP, Singh PK,
JB, Sposato LA, Sreeramareddy CT, Stathopoulou V, Steel N, Stein DJ, Steiner TJ,
B, Taylor HR, Ao BJ, Tedla BA, Terkawi AS, Thomson AJ, Thorne-Lyman AL, Thrift
Dimbuene ZT, Tsilimbaris M, Tura AK, Tuzcu EM, Tyrovolas S, Ukwaja KN, Undurraga
EA, Uneke CJ, Uthman OA, van Gool CH, Varakin YY, Vasankari T, Venketasubramanian
N, Verma RK, Violante FS, Vladimirov SK, Vlassov VV, Vollset SE, Wagner GR,
Werdecker A, Westerman R, White RA, Williams HC, Wiysonge CS, Wolfe CD, Won S,
Yebyo HG, Yip P, Yonemoto N, Yoon SJ, Younis MZ, Yu C, Zaidi Z, Zaki ME, Zeeb H,
Erratum in
Comment in
Comment on
the ability of the world's population to live in full health, a trend largely
For the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD
2015), we estimated the incidence, prevalence, and years lived with disability
for diseases and injuries at the global, regional, and national scale over the
METHODS: We estimated incidence and prevalence by age, sex, cause, year, and
Improvements from GBD 2013 included the addition of new data sources, updates to
and incidence by cause and sequelae were determined with DisMod-MR 2.1, an
for GBD 2010 and GBD 2013. For some causes, we used alternative modelling
strategies where the complexity of the disease was not suited to DisMod-MR 2.1 or
where incidence and prevalence needed to be determined from other data. For GBD
2015 we created a summary indicator that combines measures of income per capita,
used it to compare observed patterns of health loss to the expected pattern for
prevalence, incidence, and YLDs for causes, sequelae, and impairments by age,
sex, geography, and year. In 2015, two causes had acute incidences in excess of 1
billion). Eight causes of chronic disease and injury each affected more than 10%
that affected the greatest number of people in 2015 was anaemia, with 2·36
billion (2·35-2·37 billion) individuals affected. The second and third leading
impairments by number of individuals affected were hearing loss and vision loss,
respectively. Between 2005 and 2015, there was little change in the leading
causes of years lived with disability (YLDs) on a global basis. NCDs accounted
rates were decreasing, the rate of decrease for YLDs was slower than that of
years of life lost (YLLs) for nearly every cause included in our analysis. For
low SDI geographies, Group 1 causes typically accounted for 20-30% of total
tropical diseases, HIV/AIDS, and tuberculosis. Lower back and neck pain was the
leading global cause of disability in 2015 in most countries. The leading cause
was sense organ disorders in 22 countries in Asia and Africa and one in central
continued increase in years lived with disability (YLDs) as well as the rate of
the variable quality of the data available, the standardised and comprehensive
approach of the GBD study provides opportunities to examine broad trends, compare
article under the CC BY license. Published by Elsevier Ltd.. All rights reserved.
DOI: 10.1016/S0140-6736(16)31678-6
PMCID: PMC5055577
Author information:
(1)United Nations Population Fund, Peru Country Office, Av. Guardia Civil 1231,
430, Urb. Ingeniería, San Martín de Porres, Lima 31, Peru; CRONICAS Center of
Jaime.Miranda@upch.pe.
change. This article discusses the current debate about epidemiologic transition
for disease surveillance and meeting global targets; health system, prevention,
are identified. This article concludes that a focus on the most populated regions
of the world will contribute substantially to protecting the large gains in
global survival and life expectancy accrued over the last decades.
DOI: 10.1016/j.ccl.2016.08.004
PMCID: PMC5134924
nothing to disclose.
Feb 24.
Qin L(1), Chen S(2), Flood E(3), Shaunik A(2), Romero B(3), de la Cruz M(3),
Author information:
(4)ICON plc, Medical Affairs Statistical Analysis, San Diego, CA, USA.
attributes of GLP-1RAs. The DCE survey included eight attributes: efficacy, side
efficacy/safety, and dosing frequency. Odds ratios (ORs) and 95% confidence
intervals (CIs) were calculated using a conditional logit model indicating the
respondents were being treated with exenatide QW and 54.7% respondents were being
in HbA1c) (OR 2.58; 95% CI 2.37, 2.80; p < 0.001), fewer side effects (OR 2.67;
95% CI 2.52, 2.82; p < 0.001), once-weekly rather than once-daily administration
(OR 2.26; 95% CI 2.13, 2.39; p < 0.001), and the preparation required for a
multi-use pen (OR 1.71; 95% CI 1.55, 1.88; p < 0.001). Needle size, device size,
treatment adherence.
FUNDING: AstraZeneca.
DOI: 10.1007/s13300-017-0237-8
PMCID: PMC5380499
PMID: 28236271
142. PLoS One. 2018 Jun 7;13(6):e0198626. doi: 10.1371/journal.pone.0198626.
eCollection 2018.
Author information:
(1)Department of Basic Medical Sciences, The University of the West Indies, Mona,
Jamaica.
Jamaica.
(4)Caribbean Institute for Health Research, The University of the West Indies,
Mona, Jamaica.
(5)Health Research Unit, Faculty of Medical Sciences, The University of the West
concentrations (0.90 ± 0.42 vs. 0.35 ± 0.30 mmol/L; P = 0.001) and absolute
synthesis rates (1.03 ± 0.55 vs. 0.50 ± 0.69 mmol/L/day; P = 0.01), but not
fractional synthesis rates (114 ± 45 vs. 143 ± 82%/day; P = 0.07). The magnitudes
between T2DM patients with and without complications (P-values > 0.1). Fasting
glucose and HbA1c did not correlate with GSH concentration or synthesis rates
non-glycemic mechanisms.
DOI: 10.1371/journal.pone.0198626
PMCID: PMC5991679
PMID: 29879181
interests exist.
MD, USA.
AIM: Higher haemoglobin levels and differences in glucose metabolism have been
performance of HbA1c . This study explores the relationship between HbA1c and
METHODS: Data from 3613 Peruvian adults without a known diagnosis of diabetes
from sea-level and high-altitude settings were evaluated. Linear, quadratic and
RESULTS: At sea level and high altitude, means were 13.5 and 16.7 g/dl (P > 0.05)
for haemoglobin level; 41 and 40 mmol/mol (5.9% and 5.8%; P < 0.01) for HbA1c ;
and 5.8 and 5.1 mmol/l (105 and 91.3 mg/dl; P < 0.001) for FPG, respectively. The
adjusted relationship between HbA1c and FPG was quadratic at sea level and linear
48 mmol/mol (6.5%), the corresponding mean FPG values at sea level and high
altitude were 6.6 and 14.8 mmol/l (120 and 266 mg/dl), respectively. An HbA1c
cut-off of 48 mmol/mol (6.5%) had a sensitivity for high FPG of 87.3% (95%
confidence interval (95% CI) 76.5 to 94.4) at sea level and 40.9% (95% CI 20.7 to
CONCLUSION: The relationship between HbA1c and FPG is less clear at high altitude
than at sea level. Caution is warranted when using HbA1c to diagnose diabetes
© 2017 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on
DOI: 10.1111/dme.13335
PMCID: PMC5432378
Observational Study.
Martinez L(1)(2), Zhu L(3), Castellanos ME(1)(2), Liu Q(3), Chen C(3)(4)(5),
Author information:
Athens.
risk for active tuberculosis, and poor glycemic control may exacerbate this risk.
tuberculosis, is unknown.
laboratory tests including hemoglobin A1C (HbA1C), fasting plasma glucose (FPG),
tuberculin skin tests, and glycemic control was assessed linearly and
tuberculosis infection (adjusted odds ratio [AOR], 1.5; 95% confidence interval
2.2 and 1.2 in diagnosed diabetics), FPG >130 mg/dL (AOR, 2.6 and 1.3 in
diabetics with FPG ≤130 mg/dL), or not on insulin (AOR, 1.7 and 0.8 in diabetics
analysis, increasing values of FPG (AOR, 1.02 per 1-mg/dL; 95% CI, 1.01-1.03), PG
(AOR, 1.02 per 1-mg/dL; 95% CI, 1.01-1.04), and HbA1C (AOR, 1.13 per 1%; 95% CI,
Conclusions: Our results suggest glycemic control may modify the relationship
© The Author 2017. Published by Oxford University Press for the Infectious
journals.permissions@oup.com.
DOI: 10.1093/cid/cix632
Author information:
(1)Department of Food Science & Human Nutrition, Iowa State University, Ames, IA
Legumes, such as black beans (Phaseolus vulgaris L.) and chickpeas (Cicer
arietinum L.), have a low glycemic index, and may reduce the glycemic load of
meals in which they are included. Although the low glycemic response of beans
consumed alone has been documented, few studies have examined the glycemic
chickpeas and rice. This randomized cross-over study examined the glycemic and
plain white rice (control), black beans with rice, and chickpeas with rice among
healthy adult women (n = 12, 18-65 years). Treatments were consumed on different
(fasting), and at 30, 60, 90, and 120 min postprandial, and were subsequently
analyzed for glucose and insulin concentrations. Glucose response based on the
for the black bean meal and the chickpea meal in comparison to rice alone at 60
min (p = 0.026 and p = 0.024), 90 min (p = 0.001 and p = 0.012) and 120 min post
black beans and chickpeas with white rice improve glycemic response, providing
postprandial glucose and related health risks through traditional food patterns.
DOI: 10.3390/nu9101095
PMCID: PMC5691712
Author information:
exhibit a sex difference. Investigators often use male rodents because they show
metabolic disease better than females. Thus, females are not used precisely
understand novel factors reducing metabolic disease more in one sex than the
and peer reviewers who often lack expertise in model systems and experimental
sex differences in metabolic homeostasis and disease, using animal models and
cells. We also highlight current limitations in research tools and attitudes that
research.
DOI: 10.1016/j.cmet.2017.04.033
PMCID: PMC5516948
147. Pediatr Diabetes. 2018 May;19(3):375-380. doi: 10.1111/pedi.12596. Epub 2017 Oct
30.
adolescents: Evidence from National Health and Nutrition Examination Survey 2011
to 2014.
resistance [HOMA-IR]) and glucose metabolism (fasting and 2-hour glucose levels)
in adolescents from the National Health and Nutrition Examination Survey (NHANES)
2011 to 2014.
METHODS: The study included 959 participants aged 12 to 19 years who underwent a
handgrip test and a glucose tolerance test. General linear models were used to
examine the associations between handgrip strength and the outcome variables.
RESULTS: After adjustment for age, race, sex, body mass index, and physical
between handgrip strength and fasting glucose levels (P = .77), handgrip strength
was inversely associated with 2-hour glucose levels (P < .0001). Insulin and
2-hour glucose levels decreased linearly as handgrip strength increased from the
bottom quartile to the top quartile (P for trend: .045 for fasting insulin levels
increasing muscular fitness may have beneficial effects for early prevention of
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
DOI: 10.1111/pedi.12596
Hewage SS(1), Singh SR(1), Chi C(2), Chan JKY(3)(4), Yew TW(5), Han WM(6), Yoong
J(1)(7).
Author information:
Singapore.
Singapore.
Singapore.
Singapore.
(7)University of Southern California, Center for Economic and Social Research,
IN BRIEF Gestational diabetes mellitus (GDM) increases the risk for type 2
diabetes risk among women with previous GDM in Singapore. Health care providers
acknowledged a shared responsibility. They felt that they had less understanding
DOI: 10.2337/cd17-0063
PMID: 29686455
eCollection 2018.
Gabric K(#)(1)(2), Matetic A(#)(1), Vilovic M(1), Ticinovic Kurir T(1), Rusic
Author information:
Croatia.
Croatia.
Croatia.
(#)Contributed equally
(HRQoL) in type 2 diabetes mellitus (T2DM) patients with different risk for
466 adult patients with T2DM on regular visit to Center for Diabetes of
University Hospital of Split from April to September 2017. All subjects underwent
Observed apnea, and high blood Pressure) questionnaire to assess risk for OSA,
Epworth Sleepiness Scale to assess daytime sleepiness, and Medical Outcomes Study
Results: Most subjects (N=312, 67.0%) represented high-risk OSA group based on
scores in all SF-36 dimensions were found in T2DM patients with high risk for OSA
independent predictor for all SF-36 components, adjusted for body mass index,
Conclusion: Our study found that high proportion of patients with T2DM are at
high risk for OSA. Furthermore, we showed that group of T2DM patients with high
risk for OSA has lower HRQoL in all SF-36 dimensions compared to low-risk
patients.
DOI: 10.2147/PPA.S165203
PMCID: PMC5953311
PMID: 29785091
10.1080/19485565.2018.1451300.
Thomas D(1), Seeman T(2), Potter A(3), Hu P(2), Crimmins E(4), Herningtyas EH(5),
Author information:
(1)a Economics Department and Duke Global Health Institute , Duke University ,
Durham , NC , USA.
CA , USA.
, USA.
Indonesia.
(HPLC) assays with venous blood and dried blood spots (DBS) are compared for 143
upward biased for HbA1c<8% and the fraction diabetic (HbA1c ≥ 6.5%) is overstated
identical to venous-based values. When DBS are collected under field conditions,
the recalculated values are unbiased, but only about half the HbA1c values are
measured reliably, calling into question the validity of the other half. The
DOI: 10.1080/19485565.2018.1451300
PMID: 29741414
Po HL(7), Bair MJ(8), Liu CC(2), Su TH(6), Chen CL(4), Liu CJ(4)(6), Shih
SC(1)(2)(3)(5).
Author information:
60 years, male sex, BMI > 27, LDL > 130 mg/dL, HbA1c ≥ 6.5%, hs-CRP > 0.3 mg/L
and H. pylori infection were independent risk factors for synchronous colorectal
-negative groups, the proportions and odds ratio (OR) for synchronous colon
adenoma and carotid artery plaque increased with increasing HbA1c. OR for
synchronous colon adenoma and carotid artery plaque was significantly higher in
the participants with HbA1c levels of 5.7%-6.4% and HbA1c ≥ 6.5% than in those
with normal HbA1c in the H. pylori-negative group. The OR was more significant
increased for H. pylori-positive patients when HbA1c level ≥ 6.5% was 15.87 (95%
Materials and Methods: The records of 4669 subjects aged > 40 years who underwent
January 2006 to December 2015 were reviewed. All subjects had a gastric biopsy
risk factor for synchronous colorectal adenoma and carotid artery plaque
prevalence areas.
DOI: 10.18632/oncotarget.22094
PMCID: PMC5752471
PMID: 29312558
the manuscript.
Author information:
Albany, NY.
(2)Department of Endocrinology, Kazan State Medical University, Kazan, Russia.
and experts have differing opinions regarding the most optimal blood pressure
targets and treatments to lower vascular risks in the diabetes population. The
guidelines with particular attention to the origins and evidence behind these
recommendations.
DOI: 10.2337/ds17-0085
PMID: 30140137
153. J Clin Invest. 2018 Jan 2;128(1):309-322. doi: 10.1172/JCI89333. Epub 2017 Nov
27.
Tanigaki K(1), Sacharidou A(1), Peng J(1), Chambliss KL(1), Yuhanna IS(1), Ghosh
D(2)(3), Ahmed M(1), Szalai AJ(4), Vongpatanasin W(5), Mattrey RF(3), Chen Q(6),
Azadi P(6), Lingvay I(7), Botto M(8), Holland WL(9), Kohler JJ(10), Sirsi
Author information:
USA.
Georgia, USA.
Kingdom.
Despite becoming obese on a high-fat diet (HFD), mice lacking FcγRIIB globally or
resistance. Moreover, IgG transferred from patients with T2DM but not from
effects were attributed to hyposialylation of the Fc glycan, and IgG from T2DM
DOI: 10.1172/JCI89333
PMCID: PMC5749535
PMID: 29202472
154. Oxid Med Cell Longev. 2017;2017:5350267. doi: 10.1155/2017/5350267. Epub 2017 May
8.
Nitrate.
Author information:
reactive oxygen species (ROS) and decreases the production of NO. Nitrate can
restore NO depletion and has antioxidant properties, and recent data support the
obesity/diabetes, the combined effects have not been investigated yet. This
review discusses some aspects of tissue oxygenation and the potential effects of
proposed that concomitant use of hyperoxia and nitrate is justified for managing
DOI: 10.1155/2017/5350267
PMCID: PMC5457776
2017.
Amorpha fruticosa - A Noxious Invasive Alien Plant in Europe or a Medicinal Plant
Kozuharova E(1), Matkowski A(2), Woźniak D(2), Simeonova R(3), Naychov Z(4),
Author information:
SofiaSofia, Bulgaria.
(7)ICHAT and Institute for Life Sciences, University of Agricultural Sciences and
SciencesTehran, Iran.
SciencesJastrzebiec, Poland.
Amorpha fruticosa L. (Fabaceae) is a shrub native to North America which has been
cultivated mainly for its ornamental features, honey plant value and protective
properties against soil erosion. It is registered amongst the most noxious
points to the therapeutic potential of its chemical constituents. Due to the fact
and cheap resource of plant chemical constituents which can be utilized for
reviewed are aspects related to potential toxicity of A. fruticosa which has not
DOI: 10.3389/fphar.2017.00333
PMCID: PMC5462938
PMID: 28642702
156. BMC Health Serv Res. 2018 May 2;18(1):316. doi: 10.1186/s12913-018-3148-0.
validation study.
GL(7)(5)(8)(10), Tu K(8)(11)(12).
Author information:
4th Floor, 155 College St, Toronto, ON, M5T 3M6, Canada.
Lorraine.Lipscombe@wchospital.ca.
(6)Dalla Lana School of Public Health, University of Toronto, 6th Floor, 155
4th Floor, 155 College St, Toronto, ON, M5T 3M6, Canada.
(9)Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, M4N 3M5,
Canada.
(10)Li Ka Shing Knowledge Institute, St. Michael's Hospital, 30 Bond St, Toronto,
BACKGROUND: Health care data allow for the study and surveillance of chronic
diseases such as diabetes. The objective of this study was to identify and
validate optimal algorithms for diabetes cases within health care administrative
diabetes case definitions, using combinations of data sources and time windows.
RESULTS: The best algorithm to identify diabetes cases was the presence at any
time of one hospitalization or physician claim for diabetes AND either one
predictive value (PPV) 92.5%]. Use of physician claims alone performed almost as
well: three physician claims for diabetes within one year was highly specific
(sensitivity 79.9%, specificity 99.1%, PPV 91.4%) and one physician claim at any
time was highly sensitive (sensitivity 93.6%, specificity 91.9%, PPV 58.5%).
and data availability. These findings are useful to study trends and outcomes of
DOI: 10.1186/s12913-018-3148-0
PMCID: PMC5932874
PMID: 29720153
Nov 1.
Wang X(1), Chen J(1), Liu X(1), Gao F(1), Zhao H(1), Han D(1), Jing X(1), Liu
Author information:
lichangping@tmu.edu.cn.
junma@tmu.edu.cn.
aims of this study were to identify distinct subgroups of people with type 2
METHODS: In 2015 and 2016, 1504 outpatients with a diagnosis of type 2 diabetes
were selected via two-stage simple random sampling from 10 municipal district
content. Clinical data were collected by reviewing medical records. Latent class
RESULTS: The final model yielded a four-class solution: the healthy behavioral
group, unhealthy diet and less activity group, smoking and drinking group, and
sedentary and extremely inactive group. Further analysis found that variables,
were disproportionately distributed across the four latent classes (P < 0.05).
Participants in the unhealthy diet and less activity group were more likely to
behaviors in individuals with type 2 diabetes can help health care providers to
DOI: 10.1007/s13300-017-0327-7
PMCID: PMC5688992
PMID: 29094299
158. Oxid Med Cell Longev. 2018 Aug 14;2018:2378189. doi: 10.1155/2018/2378189.
eCollection 2018.
Mandò C(1), Anelli GM(1), Novielli C(1), Panina-Bordignon P(2), Massari M(1),
Author information:
(2)Division of Genetics and Cell Biology, IRCCS Ospedale San Raffaele, Via
Here, we hypothesize that maternal pregestational body mass index (BMI) and
women were normoglycemic: twenty-one normal-weight women, NW, and sixteen obese
women, OB/GDM(-). Ten obese women had gestational diabetes mellitus, OB/GDM(+).
DOI: 10.1155/2018/2378189
PMCID: PMC6112210
PMID: 30186542
high-fat diet.
Y(10), Nurdin SME(11), Iskandar E(8)(9), Minggu D(12), Yunir E(6)(7), Guigas
B(5), Supali T(8)(9), Rensen PCN(10), Sartono E(5), Soewondo P(6)(7), Harbuwono
Author information:
Netherlands. dicky.tahapary@ui.ac.id.
(3)Nangapanda Community Research Cluster, The Indonesian Medical Education and
dicky.tahapary@ui.ac.id.
dicky.tahapary@ui.ac.id.
Netherlands.
Jakarta, Indonesia.
The Netherlands.
Netherlands. m.yazdanbakhsh@lumc.nl.
response to a short-term high-fat high-calorie diet (HFD) of men with the same
rural area (Flores) and 49 had migrated and lived in urban area (Jakarta) for
more than 1 year. The urban group had significantly higher whole-body insulin
for a 5-day HFD challenge. The HOMA-IR increased in both groups similarly -0.77
(-2.03-0.49), p = 0.22]. Neither rural living nor factors associated with rural
living, such as current helminth infection or total IgE, were associated with
DOI: 10.1038/s41598-018-25092-6
PMCID: PMC5970191
PMID: 29802315
160. Diab Vasc Dis Res. 2018 Jul;15(4):302-313. doi: 10.1177/1479164118759220. Epub
2018 Mar 2.
Blanco F(1)(2), Heinonen SE(3), Gurzeler E(4), Berglund LM(1), Dutius Andersson
Author information:
AIMS: Despite vast clinical experience linking diabetes and atherosclerosis, the
inhibition on plaque burden in a novel mouse model of type 2 diabetes that better
In vivo treatment with the nuclear factor of activated T-cells blocker A-285222
for 4 weeks reduced atherosclerotic plaque area and degree of stenosis in the
(i.e. muscle, collagen, macrophages). The reduced plaque area could not be
complications.
DOI: 10.1177/1479164118759220
PMCID: PMC6039864
PMID: 29499628 [Indexed for MEDLINE]
Ohlsson C(1), Hammarstedt A(2), Vandenput L(1), Saarinen N(3), Ryberg H(1),
Windahl SH(1), Farman HH(1), Jansson JO(4), Movérare-Skrtic S(1), Smith U(2),
Author information:
Sweden.
mice). Adipose tissue E2 levels were increased while circulating SS levels were
unaffected in male Ap2-arom mice. Importantly, male Ap2-arom mice were more
insulin sensitive compared with WT mice and exhibited increased serum adiponectin
levels and upregulated expression of Glut4 and Irs1 in WAT. The expression of
markers of macrophages and immune cell infiltration was markedly decreased in WAT
of male Ap2-arom mice. The adipogenesis was enhanced in male Ap2-arom mice,
and adipogenesis.
DOI: 10.1152/ajpendo.00093.2017
PMCID: PMC5668598
20.
Zeng CP(1)(2), Chen YC(1), Lin X(1), Greenbaum J(3), Chen YP(2), Peng C(1), Wang
Author information:
type 2 diabetes (T2D) and low birth weight. However, the nature of the
relationship is largely unknown. The aim of this study was to identify novel
single nucleotide polymorphisms (SNPs) in T2D and birth weight, and their
pleiotropic loci.
SNPs, including 12 novel SNPs (cFDR < 0.05) were identified. Conjunctional cFDR
(ccFDR) analysis identified nine pleiotropic loci, including seven novel loci,
shared by both T2D and birth weight (ccFDR < 0.05). Two novel SNPs located at the
0.05) and adenylate cyclase 5 (ADCY5; rs4677887; cFDR < 0.05) genes are of note.
These two genes increase the risk of T2D and low birth weight through the pathway
CONCLUSION: Several pleiotropic loci were identified between T2D and birth weight
DOI: 10.1111/1753-0407.12510
PMCID: PMC5841537
IndEcho study: cohort study investigating birth size, childhood growth and young
Vasan SK(1)(2), Roy A(3)(4), Samuel VT(5), Antonisamy B(5), Bhargava SK(6), Alex
AG(5), Singh B(6), Osmond C(1), Geethanjali FS(5), Karpe F(2), Sachdev H(7),
Agrawal K(5), Ramakrishnan L(4), Tandon N(4), Thomas N(5), Premkumar PS(5),
Asaithambi P(5), Princy SFX(5), Sinha S(7), Paul TV(5), Prabhakaran D(3)(8), Fall
CHD(1).
Author information:
India.
INTRODUCTION: South Asians have high rates of cardiovascular disease (CVD) and
Left ventricular (LV) hypertrophy and dysfunction are features of these disorders
and important predictors of CVD mortality. Lower birth and infant weight and
greater childhood weight gain are associated with increased adult CVD mortality,
but there are few data on their relationship to LV function. The IndEcho study
will examine associations of birth size, growth during infancy, childhood and
adolescence and CVD risk factors in young adulthood with midlife cardiac
METHODS AND ANALYSIS: We propose to study approximately 3000 men and women aged
43-50 years from two birth cohorts established in 1969-1973: the New Delhi Birth
Cohort (n=1508) and Vellore Birth Cohort (n=2156). They had serial measurements
of weight and height from birth to early adulthood. CVD risk markers (body
Outcomes are LV mass and indices of LV systolic and diastolic function assessed
ETHICS AND DISSEMINATION: The study has been approved by the Health Ministry
© Article author(s) (or their employer(s) unless otherwise stated in the text of
the article) 2018. All rights reserved. No commercial use is permitted unless
DOI: 10.1136/bmjopen-2017-019675
PMCID: PMC5898335
PMID: 29643156
164. Diabetes Care. 2018 Jun;41(6):1268-1274. doi: 10.2337/dc17-2046. Epub 2018 Apr 4.
Author information:
RESEARCH DESIGN AND METHODS: Patients ≥45 years of age who underwent noncardiac
surgery from January 2004 to December 2013 were identified using the U.S.
major noncardiac surgery; DM was present in ∼23% of surgeries and increased over
surgeries vs. 2.8% of surgeries for patients without DM (P < 0.001). From 2004 to
-6) for patients without DM (P for interaction <0.001). Trends for individual end
points were all less favorable for patients with DM versus those without DM.
U.S. hospital admission database, perioperative MACCEs were more common among
patients with DM versus those without DM. Perioperative MACCEs increased over
time and individual end points were all less favorable for patients with DM. Our
findings suggest that a substantial unmet need exists for strategies to reduce
DOI: 10.2337/dc17-2046
Author information:
Massachusetts.
Shanghai, China.
Massachusetts.
of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston,
Massachusetts.
Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts;
Health, Department of Medicine, Brigham and Women's Hospital and Harvard Medical
Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
diabetes.
moderation (5 to 15 g/day for women and 5 to 30 g/day for men), with the risk of
developing cardiovascular disease (CVD) and CVD mortality among adults with type
2 diabetes (T2D).
diagnosed during follow-up (8,970 women from the Nurses' Health Study and 2,557
men from the Health Professionals Follow-Up Study), who were free of CVD and
cancer at the time of diabetes diagnosis. Diet and lifestyle factors before and
RESULTS: There were 2,311 incident CVD cases and 858 CVD deaths during an average
low-risk lifestyle factors after diabetes diagnosis were each associated with a
lower risk of CVD incidence and CVD mortality. The multivariate-adjusted hazard
ratios for participants with 3 or more low-risk lifestyle factors compared with 0
were 0.48 (95% confidence interval [CI]: 0.40 to 0.59) for total CVD incidence,
0.53 (95% CI: 0.42 to 0.66) for incidence of coronary heart disease, 0.33 (95%
CI: 0.21 to 0.51) for stroke incidence, and 0.32 (95% CI: 0.22 to 0.47) for CVD
adherence to the overall healthy lifestyle (<3 low-risk factors) was 40.9% (95%
significantly associated with a lower risk of CVD incidence and CVD mortality.
For each number increment in low-risk lifestyle factors there was a 14% lower
risk of incident total CVD, a 12% lower risk of coronary heart disease, a 21%
lower risk of stroke, and a 27% lower risk of CVD mortality (all p < 0.001).
Similar results were observed when analyses were stratified by diabetes duration,
sex/cohort, body mass index at diabetes diagnosis, smoking status, and lifestyle
a substantially lower risk of CVD incidence and CVD mortality among adults with
T2D. These findings further support the tremendous benefits of adopting a healthy
DOI: 10.1016/j.jacc.2018.04.027
PMID: 29929608
Author information:
(3)Austrian Competence Center for Feed and Food Quality, Safety and Innovation,
(6)Austrian Competence Center for Feed and Food Quality, Safety and Innovation,
Austria. markus.himmelsbach@jku.at.
marcus.iken@pm-international.de.
(11)Austrian Competence Center for Feed and Food Quality, Safety and Innovation,
of deaths worldwide each year; 90% of all people suffering from DM are classified
extracts that induce GLUT4 translocation in the absence of insulin, and confirmed
their activity in chick embryos. We found that extracts prepared from Bellis
applied in vitro cell system. In addition, these extracts also led to reduced
blood glucose levels in chicken embryos (in ovo), confirming their activity in a
blood glucose levels and are therefore suitable candidates for application in
DOI: 10.3390/molecules23102605
PMCID: PMC6222741
PMID: 30314325
eCollection 2018.
Pedro MN(1), Rocha GZ(1), Guadagnini D(1), Santos A(1), Magro DO(2), Assalin
Author information:
(3)Biosciences Institute, São Paulo State University (UNESP), Rio Claro, Brazil.
Here we review how immune activation and insulin resistance contribute to the
alterations increase the risk of developing CVD. The introduction and evolution
of antiretroviral drugs over the past 25 years has completely changed the
now related to atherosclerotic CVDs, rather than from the viral infection itself.
However, HIV infection, cART, and intestinal microbiota are associated with
immune activation and insulin resistance, which can lead to the development of a
variety of diseases and disorders, especially with regards to CVDs. The increase
elucidation and understanding of these mechanisms will give rise to new classes
of drugs that will further improve the quality of life of HIV-infected patients,
DOI: 10.3389/fendo.2018.00514
PMCID: PMC6133958
PMID: 30233499
Jun 7.
Interaction between genes and macronutrient intake on the risk of developing type
Li SX(1), Imamura F(1), Ye Z(1), Schulze MB(2)(3), Zheng J(1), Ardanaz E(4)(5),
PW(10)(11), Agudo A(12), Grioni S(13), Kaaks R(14), Katzke VA(14), Key TJ(15),
NC(19), Overvad K(20)(21), Palli D(22), Panico S(23), Quirós JR(24), Rolandsson
I(19), Spijkerman AM(31), Tjonneland A(32), Tumino R(33), Sharp SJ(1), Riboli
E(34), Langenberg C(1), Scott RA(1), Forouhi NG(35), Wareham NJ(1).
Author information:
Heidelberg, Germany.
Aarhus, Denmark.
Italy.
(31)National Institute for Public Health and the Environment (RIVM), Bilthoven,
Netherlands.
existing evidence for gene-macronutrient interactions and T2D and to examine the
MEDLINE, Human Genome Epidemiology Network, and WHO International Clinical Trials
country-specific HRs, 95% CIs, and P-interaction values, which were then pooled
covariates as reported in the published studies, and a second model adjusted for
glycemic load derived from self-report of dietary intake and circulating n-3
identified for the risk of T2D from the literature. These interactions were not
DOI: 10.3945/ajcn.116.150094
PMCID: PMC5486199
169. Clin Interv Aging. 2017 Mar 16;12:535-541. doi: 10.2147/CIA.S126207. eCollection
2017.
Is diabetes mellitus associated with clinical outcomes in aging males treated
Lin YH(1), Hou CP(2), Chen TH(3), Juang HH(4), Chang PL(2), Yang PS(2), Lin
Author information:
Medicine.
Tao-Yuan.
PURPOSE: We assessed the lower urinary tract symptoms (LUTSs) and clinical
Database (NHIRD). A total of 4,887 patients who had persistent LUTSs and
underwent TUR-P for prostate enlargement (benign prostate enlargement [BPE]) were
enrolled and divided into two groups: DM and non-DM groups. The patients'
after TUR-P were compared. Chi-square test was used for categorical variables and
independent samples t-test for continuous variables. Multivariable logistic
Kaplan-Meier method and compared it between study groups using log-rank test.
Postoperatively, the DM group had lower rates of urinary tract infection (UTI;
odds ratio [OR], 0.78; P=0.009) and higher rates of urinary retention requiring
the first 3 months and α-blockers (OR, 1.18; P=0.049) during 3-12 months after
DOI: 10.2147/CIA.S126207
PMCID: PMC5360412
170. Biomed Res Int. 2018 Mar 22;2018:4507659. doi: 10.1155/2018/4507659. eCollection
2018.
Meng F(1), Lin Y(1), Yang M(1), Li M(1), Yang G(2), Hao P(3), Li L(1).
Author information:
exact role in chronic inflammation remains unclear. This study aimed to examine
Methods: Mouse models of high-fat diet- (HFD-) induced insulin resistance were
induced using C57BL/6J and JAZF1-overexpressing (JAZF1-OX) mice. The mice were
randomized (8-10/group) to C57BL/6J mice fed regular diet (RD) (NC group),
C57BL/6J mice fed HFD (HF group), JAZF1-OX mice fed RD (NJ group), and JAZF1-OX
mice fed HFD (HJ group). Adipose tissue was harvested 12 weeks later. ATMs were
Results: JAZF1-OX mice had lower blood lipids, blood glucose, body weight, fat
weight, and inflammatory markers compared with HF mice (all P < 0.05). JAZF1
JAZF1 overexpression decreased total CD4+ T cells, active T cells, and memory T
cells and increased Treg cells. JAZF1 overexpression downregulated IFN-γ and
IL-17 levels and upregulated IL-4 levels. JAZF1 overexpression decreased MHCII,
CD40, and CD86 in total ATM, CD11c+ ATM, and CD206+ ATM.
DOI: 10.1155/2018/4507659
PMCID: PMC5885486
Laboratory-based and office-based risk scores and charts to predict 10-year risk
Aguilar-Salinas CA(6), Ahmadvand A(7), Azizi F(8), Bentham J(9), Cifkova R(10),
Di Cesare M(11), Eriksen L(12), Farzadfar F(13), Ferguson TS(14), Ikeda N(15),
Khalili D(16), Khang YH(17), Lanska V(18), León-Muñoz L(19), Magliano DJ(20),
JE(20), Stevens GA(28), Tolstrup JS(12), Zhou B(29), Salomon JA(1), Ezzati M(30),
Danaei G(31).
Author information:
(2)The George Institute for Global Health, University of Oxford, Oxford, UK; The
George Institute for Global Health, University of Sydney, Sydney, NSW, Australia;
(3)Yale/Yale-New Haven Hospital, Center for Outcomes Research and Evaluation, New
Kuwait.
(7)MRC-PHE Centre for Environment and Health, Imperial College London, London,
(11)MRC-PHE Centre for Environment and Health, Imperial College London, London,
Copenhagen, Denmark.
Czech Republic.
(24)Division of Health and Nutrition Survey, Korea Centers for Disease Control
(29)MRC-PHE Centre for Environment and Health, Imperial College London, London,
(30)MRC-PHE Centre for Environment and Health, Imperial College London, London,
Imperial College London, London, UK; WHO Collaborating Centre on NCD Surveillance
and Epidemiology, Imperial College London, London, UK; Wellcome Trust Centre for
Comment in
for the target country and can be used where laboratory measurements are
countries to predict 10-year risk of fatal and non-fatal CVD in adults aged 40-74
years.
used data from eight prospective studies to estimate coefficients of the risk
included age, sex, smoking, blood pressure, diabetes, and total cholesterol; in
cholesterol with BMI. We recalibrated risk scores for each sex and age group in
each country using country-specific mean risk factor levels and CVD rates. We
used recalibrated risk scores and data from national surveys (using data from
different levels of CVD risk for ten countries from different world regions as
examples of the information the risk scores provide; we applied a risk threshold
for high risk of at least 10% for high-income countries (HICs) and at least 20%
for low-income and middle-income countries (LMICs) on the basis of national and
and women who were similarly categorised as high risk or low risk by the two risk
scores.
FINDINGS: Predicted risks for the same risk factor profile were generally lower
in HICs than in LMICs, with the highest risks in countries in central and
southeast Asia and eastern Europe, including China and Russia. In HICs, the
proportion of people aged 40-64 years at high risk of CVD ranged from 1% for
South Korean women to 42% for Czech men (using a ≥10% risk threshold), and in
low-income countries ranged from 2% in Uganda (men and women) to 13% in Iranian
men (using a ≥20% risk threshold). More than 80% of adults were similarly
INTERPRETATION: Our risk charts provide risk assessment tools that are
recalibrated for each country and make the estimation of CVD risk possible
DOI: 10.1016/S2213-8587(17)30015-3
PMCID: PMC5354360
172. BMJ Open Diabetes Res Care. 2016 Oct 3;4(1):e000294. eCollection 2016.
40).
Yokoyama H(1), Oishi M(2), Takamura H(3), Yamasaki K(4), Shirabe SI(5), Uchida
Author information:
(1)Department of Internal Medicine , Jiyugaoka Medical Clinic , Obihiro , Japan.
Japan.
OBJECTIVE: The fact that population with type 2 diabetes mellitus and bodyweight
multicenter-based cohort.
9956 subjects with type 2 diabetes mellitus who consecutively attended primary
RESULTS: The rates of achieving targets for HbA1c, blood pressure, and lipids
complications was ∼28% each, 6.4% of which had all microvascular complications,
of diabetes, the rate of achieving target HbA1c decreased and the prevalence of
than those with. Adjustments for considerable covariates exhibited that each
complication was closely inter-related, and the achievement of each target was
CONCLUSIONS: Almost half of the subjects examined did not meet the recommended
and complications may be important for high-quality care. The future studies
including more subjects and clinics with precise complication status are needed.
DOI: 10.1136/bmjdrc-2016-000294
PMCID: PMC5051339
PMID: 27752329
Liu X(1), Yang ZG(1), Gao Y(1), Xie LJ(2), Jiang L(1), Hu BY(1), Diao KY(1), Shi
Author information:
(1)Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue
gykpanda@163.com.
interventions that can prevent or reverse heart failure, thereby improving the
underwent CMR examination. The T2DM patients were subdivided into two groups,
(PS), peak systolic strain rate, and peak diastolic strain rate (PSDR), and
(TTM), and max signal intensity (Max SI, were measured and compared among the
three groups. Pearson's correlation was used to evaluate the correlation between
RESULTS: Pooled data from T2DM patients showed a decrease in global longitudinal,
CONCLUSIONS: Our results imply that a contrast-enhanced 3.0T CMR can detect
perfusion in the early stages of T2DM, and that the myocardial dysfunction is
DOI: 10.1186/s12933-018-0782-0
PMCID: PMC6206833
PMID: 30373588
eCollection 2018.
Goveia P(1), Cañon-Montañez W(2), Santos DP(1), Lopes GW(1), Ma RCW(3), Duncan
Author information:
lifestyle interventions for women with previous GDM. Methods:We searched for RCTs
revealed a homogeneous (I2 = 10%), reduction of 25% (RR = 0.75; 95%CI: 0.55-1.03)
after delivery (< 6 months post-partum) were effective (RR = 0.61; 95%CI:
-1.07 kg; -1.43-0.72 kg); BMI (MD = -0.94 kg/m2; -1.79 -0.09 kg/m2); and waist
circumference (MD = -0.98 cm; -1.75 -0.21 cm) were observed, effects were larger
GDM. Benefits, although smaller than those of major trials based in older
young subset of woman. Further studies are needed to improve the quality of the
DOI: 10.3389/fendo.2018.00583
PMCID: PMC6182069
PMID: 30344509
175. Int J Environ Res Public Health. 2017 Sep 10;14(9). pii: E1041. doi:
10.3390/ijerph14091041.
Altitude in Nepal.
Author information:
nirmal.aryal.2010@gmail.com.
mark.weatherall@otago.ac.nz.
stewart@mannz.co.nz.
This study aimed to describe lipid profiles and the distribution of glycated
conducted among 521 people living at four different altitude levels, all above
(residents at 2800 m and 3620 m) had higher total cholesterol (TC) and
28.2) and high TG (≥1.7 mmol/L) in 43.3% (95% CI 38.4, 48.3) of participants
overall. Mean HbA1c levels were similar at all altitude levels although urban
participants had a higher prevalence of diabetes. Overall, 6.9% (95% CI 4.7, 9.8)
DOI: 10.3390/ijerph14091041
PMCID: PMC5615578
M(2).
Author information:
organisations is seen as relevant for the efficiency and efficacy of health and
social care because of their potential role in providing social involvement which
may reduce the need for the utilisation of formal services. Care organisations
network. This study aimed to describe and explore organisational networks with
respect to their activities for people with diabetes mellitus type 2 and
METHODS: A mixed methods study was conducted in an urban and a rural area in the
social network analysis methods was used to map and characterise the
enforced. The density, centrality, and reciprocity in the networks seemed low to
DOI: 10.1186/s13104-016-2135-y
PMCID: PMC4930621
PMID: 27369357 [Indexed for MEDLINE]
eCollection 2017.
production in macrophages.
Author information:
(ROS). Recent studies revealed that long non-coding RNAs (lncRNAs) play important
subunit of NFκB and blocking its binding to DNA and the subsequent activation of
glucose (25 mM) for 24h. High glucose conditions significantly induced ROS
production and NOX2 gene expression in RAW cells, while significantly decreasing
attenuating the upregulation of NOX2 expression. Similar results was found also
findings are consistent with the decreased Lethe gene expression and increased
NOX2 gene expression observed in a mouse model of diabetic wound healing. These
findings provide the first evidence that lncRNA Lethe is involved in the
expression via NFκB signaling. Moreover, this is the first report to describe a
DOI: 10.1371/journal.pone.0177453
PMCID: PMC5426762
JC(2), Svensson PA(2), Larsson I(4), Hjorth S(2), Neovius M(5), Taube M(2),
Gothenburg, Sweden.
Stockholm, Sweden.
(6)Chronic Disease Prevention Unit, National Institute for Health and Welfare,
Helsinki, Finland.
Comment in
in patients with prediabetes are unknown. The aim of this study was to examine
METHODS: Patients were recruited to the Swedish Obese Subjects (SOS) study
between Sept 1, 1987, and Jan 31, 2001. Inclusion criteria were age 37-60 years
and BMI of 34 kg/m2 or greater in men and 38 kg/m2 or greater in women. Exclusion
criteria were identical in surgery and control groups and designed to exclude
patients not suitable for surgery. The surgery group (n=2010) underwent gastric
bypass (265 [13%]), gastric banding (376 [19%]), or vertical-banded gastroplasty
(1369 [68%]). Participants in the control group (n=2037) received usual care.
Bodyweight was measured and questionnaires were completed at baseline and at 0·5
study visits at 2 years, 10 years, and 15 years. We did the main analysis by
glycaemic status and by diabetes status at the 15 year follow-up. The SOS study
FINDINGS: 4032 of the 4047 participants in the SOS study were included in this
had normal blood glucose, 591 had prediabetes, 246 had screen-detected diabetes,
and 357 had established diabetes. Median follow-up was 19 years (IQR 16-21). We
identified 374 incident cases of microvascular disease in the control group and
224 in the surgery group (hazard ratio [HR] 0·56, 95% CI 0·48-0·66; p<0·0001).
were lowest in the subgroup with prediabetes (0·18, 95% CI 0·11-0·30), followed
DOI: 10.1016/S2213-8587(17)30061-X
PMCID: PMC5394228
Low level activity thresholds for changes in NMR biomarkers and genes in high
S(7), Selänne H(8), Mäkelä KA(4), Ahola R(9), Jämsä T(10)(9)(11), Vidal H(7),
Keinänen-Kiukaanniemi S(5)(6).
Author information:
(3)Medical Research Center and Oulu University Hospital, University of Oulu and
Oulu, Finland.
(6)Oulu University Hospital, Unit of General Practice, and Health Center of Oulu,
Oulu, Finland.
Oullins, France.
Finland.
(10)Medical Research Center and Oulu University Hospital, University of Oulu and
amounts and intensities of physical activities (PA) on NMR biomarkers and changes
in skeletal muscle gene expressions in subjects with high risk for type 2
in the 2nd - 4th quartiles compared to the 1st quartile representing PA of less
in lipoproteins showed that the effects of PA was 4-15 times greater than those
subjects' gene expressions of oxidative fiber markers, Apo D, and G0/G1 Switch
DOI: 10.1038/s41598-017-09753-6
PMCID: PMC5603534
PMID: 28924247
Kosiborod M(1), Cavender MA(2), Fu AZ(2), Wilding JP(2), Khunti K(2), Holl RW(2),
Norhammar A(2), Birkeland KI(2), Jørgensen ME(2), Thuresson M(2), Arya N(2),
Bodegård J(2), Hammar N(2), Fenici P(2); CVD-REAL Investigators and Study Group*.
Author information:
mkosiborod@saint-lukes.org.
Comment in
METHODS: Data were collected via medical claims, primary care/hospital records,
and national registries from the United States, Norway, Denmark, Sweden, Germany,
and the United Kingdom. Propensity score for SGLT-2i initiation was used to match
treatment groups. Hazard ratios for HHF, death, and their combination were
estimated by country and pooled to determine weighted effect size. Death data
were not available for Germany.
RESULTS: After propensity matching, there were 309 056 patients newly initiated
53%, 42%, and 5% of the total exposure time in the SGLT-2i class, respectively.
Baseline characteristics were balanced between the 2 groups. There were 961 HHF
and the United Kingdom, death occurred in 1334 (incidence rate, 0.87/100
Use of SGLT-2i, versus other glucose-lowering drugs, was associated with lower
rates of HHF (hazard ratio, 0.61; 95% confidence interval, 0.51-0.73; P<0.001);
death (hazard ratio, 0.49; 95% confidence interval, 0.41-0.57; P<0.001); and HHF
or death (hazard ratio, 0.54; 95% confidence interval, 0.48-0.60; P<0.001) with
other glucose-lowering drugs was associated with a lower risk of HHF and death,
suggesting that the benefits seen with empagliflozin in a randomized trial may be
identifier: NCT02993614.
DOI: 10.1161/CIRCULATIONAHA.117.029190
PMCID: PMC5515629
clinical trials.
Srivastava GK(1).
Author information:
Retinal and optic nerve diseases are degenerative ocular pathologies which lead
mesenchymal stem cells (MSCs) have been obtained by several preclinical studies
clinical practice. Since 2008, several first steps projecting new treatment
approaches, have been taken regarding the use of cell therapy in patients with
trials using MSCs are in I/II phase, recruiting patients or ongoing, and they
have as main objective the safety assessment of MSCs using various routes of
continue preclinical and clinical studies to improve this new therapeutic tool.
This paper reviews the latest progress of MSCs in human clinical trials for
PMCID: PMC5120242
PMID: 27928464
182. Cardiovasc Res. 2017 Feb 16. doi: 10.1093/cvr/cvx022. [Epub ahead of print]
Author information:
Germany.
DOI: 10.1093/cvr/cvx022
PMCID: PMC5852643
PMID: 28203832
183. BBA Clin. 2016 Oct 2;7:41-54. doi: 10.1016/j.bbacli.2016.09.003. eCollection 2017
Jun.
Song MK(1), Bischoff DS(1), Song AM(2), Uyemura K(3), Yamaguchi DT(1).
Author information:
(1)VA Greater Los Angeles Healthcare System, 16111, Plummer Street, North Hills,
CA 91343; UCLA School of Medicine, 1O833 Le Conte Avenue, Los Angeles, CA 90095.
91402.
(3)VA Greater Los Angeles Healthcare System, 16111, Plummer Street, North Hills,
CA 91343.
ameliorated diabetes in rats and similar improvements have been seen in human
Cyclo-Z exhibited memory improvements and significantly reduced Aβ-40 and Aβ-42
SCOPE OF REVIEW: Metabolic relationship between AD and T2D will be described with
decreasing blood glucose and brain Aβ levels will be elucidated. Cyclo-Z effects
DOI: 10.1016/j.bbacli.2016.09.003
PMCID: PMC5219633
PMID: 28070499
Author information:
diseases. Studies on the MS in Brazil are recent, and its epidemiology in more
isolated regions such as the Amazon is still unknown. The study aimed to estimate
study, involving 787 adults randomly selected from the urban area of four cities
in the state of Pará, in the Brazilian Eastern Amazon. The participants underwent
their lifestyle. MS was defined by the Joint Interim Statement criteria, using
factors with the presence of MS. The overall prevalence of MS was 34.1% (95% CI =
30.8-37.4), increasing linearly with the increasing body mass index and age. From
40-49 years of age, MS was observed in about half of the women (46.0%), while men
only experienced a high prevalence in the fifth decade of life (43.3%). The low
HDL-c (64.4%) and abdominal obesity (58.9%) were higher in women (p < 0.001),
while for men, high blood pressure was significantly higher (p < 0.001).
Individuals aged 40-59 years old (odds ratio [OR] = 3.35 [95% CI = 2.30-4.90]), ≥
60 years old (OR = 5.80 [3.63-9.27]), overweight (OR = 4.17 [2.77-6.29]), and
obese (OR = 8.82 [5.56-13.98]) were more likely to have MS. The study population
PMCID: PMC5147872
interests exist.
Apr 6.
Merino J(1)(2), Leong A(2)(3), Liu CT(4), Porneala B(3), Walford GA(1)(2), von
Grotthuss M(2), Wang TJ(5), Flannick J(1)(2), Dupuis J(4)(6), Levy D(6)(7),
Author information:
(1)Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital,
USA.
(6)The Framingham Heart Study, National Heart, Lung and Blood Institute, National
Institutes of Health, Framingham, MA, USA.
(9)Broad Institute of MIT and Harvard Program in Metabolism, Cambridge, MA, USA.
JMEIGS@mgh.harvard.edu.
fasting glucose (NFG [<5.55 mmol/l]) who progressed to type 2 diabetes may give
novel insights into early type 2 diabetes disease interception and detection.
Heart Study Offspring cohort participants, age 40-65 years, with NFG. Plasma
dataset).
dataset for type 2 diabetes incidence classification and were found to improve
type 2 diabetes risk prediction beyond conventional type 2 diabetes risk factors
(AUC was 0.81 for risk factors vs 0.90 for risk factors + metabolites,
hazard models, the type 2 diabetes risk per 1 SD increase in glycine, taurine and
phenylalanine was 0.65 (95% CI 0.54, 0.78), 0.73 (95% CI 0.59, 0.9) and 1.35 (95%
relationship for type 2 diabetes risk per 1 SD genetically increased glycine (OR
0.89 [95% CI 0.8, 0.99]) and phenylalanine (OR 1.6 [95% CI 1.08, 2.4]).
risk factors. In addition, the nitrogen metabolism pathway and its components
pathophysiology.
DOI: 10.1007/s00125-018-4599-x
PMID: 29626220
PI3K/Akt pathway.
Chen Y(1), Liu G(1), He F(1), Zhang L(2), Yang K(1), Yu H(3), Zhou J(1), Gan
H(4)(5).
Author information:
diabetes on enteric glia cell (EGC) is not clear. We investigated the effect of
diabetes and hyperglycemia on EGC, and the role of microRNA375 in modulating EGC
EGC was transfected with microRNA375 inhibitor or its mimic. Diabetes mice with
DOI: 10.1038/s41598-018-30714-0
PMCID: PMC6107553
PMID: 30140011
187. Clin Epidemiol. 2017 Nov 3;9:537-544. doi: 10.2147/CLEP.S148101. eCollection
2017.
Author information:
Objective: We aimed to assess if the gap in mortality between adults with and
Methods and study design: This cohort study included 44,041 adults with diabetes
from the US National Health Interview Survey between 1986 and 2009 linked to the
National Mortality Index data up to 2011. Each participant with diabetes was
matched to two participants without diabetes by age, sex, race, survey year, and
hazard ratios were calculated for different time periods defined by three
follow-up calendar years, and 3) survey years with a fixed 3-year follow-up
duration.
different mortality rates and changing patterns over time. The decline in
mortality was higher when time periods were defined according to survey years
with original follow-up durations than with the fixed 3-year duration. Different
time periods had comparable baseline and attained ages only when the fixed
duration was used. With this method, the gap between adults with and without
diabetes progressively decreased from 224 (95% confidence interval 188-260) in
2007-2009.
Conclusion: The decline in mortality over time was greater among adults with
diabetes than those without diabetes. The gap in mortality between adults with
diabetes and those without diabetes significantly narrowed in recent years, and
DOI: 10.2147/CLEP.S148101
PMCID: PMC5679564
PMID: 29138599
188. Int J Mol Sci. 2016 Sep 7;17(9). pii: E1498. doi: 10.3390/ijms17091498.
Author information:
evidence indicates that inflammatory cytokines and chemokines other than VEGF may
contribute to the disease process. The current review examines the presence of
lead to novel therapeutics to enhance existing treatments for patients who do not
DOI: 10.3390/ijms17091498
PMCID: PMC5037775
interest. These funding sources had no role in the development or writing of this
review.
cholesterol control among South Africans living with type 2 diabetes, after a
4-year follow-up.
Pinchevsky Y(1), Shukla VJ(1), Butkow N(1), Chirwa T(2), Raal F(3).
Author information:
(LDL-C) existed among an urban multi-ethnic cohort of South Africans, living with
PATIENTS AND METHODS: This longitudinal, retrospective study consisted of 261 men
and women with previously diagnosed T2DM who attended Charlotte Maxeke
Johannesburg Academic Hospital, South Africa across two time periods 2009 and
2013. Demographic and clinical data were extracted from consecutive medical
records. The primary outcome was to determine achievements in HbA1c, BP, and
RESULTS: The mean age of the cohort was 64 (±10.6) years, females represented
55%, and the self-reported diabetes duration was 16 (±10.6) years as at 2013.
Black Africans (42.9%, n=112 of 261) were more likely to reach the HbA1c target
(<140/80 mmHg), while 90.2% of Caucasians achieved LDL-C goals (<2.5 mmol/L).
Overall, across the ethnic groups studied, we found that HbA1c control
deteriorated over time, although BP levels remained the same and LDL-C levels
drastically improved.
CONCLUSION: There was poor control of HbA1c, BP, and LDL-C across all ethnic
DOI: 10.2147/IJGM.S119965
PMCID: PMC5117891
PMID: 27895508
this work.
eCollection 2017.
Peykari N(1), Hashemi H(2), Dinarvand R(3), Haji-Aghajani M(4), Malekzadeh R(5),
Sadrolsadat A(6), Sayyari AA(7), Asadi-Lari M(8), Delavari A(9), Farzadfar F(10),
Author information:
(3)Food and Drug Organization, INCDC, Ministry of Health and Medical Education,
Tehran, Iran.
Tehran, Iran.
Tehran, Iran.
Tehran, Iran.
(15)Center for NCDs control and prevention, and INCDC, MOHME, Tehran, Iran.
(17)INCDC, Ministry of Health and Medical Education, and EMRI, TUMS, Tehran,
Iran.
Emerging Non-communicable diseases burden move United Nation to call for 25%
The World Health Organization (WHO) developed global action plan for prevention
and control NCDs, but the countries' contexts, priorities, and health care system
commitments to achieve the 25 by 25 goal through adapted targets and action plan.
DOI: 10.1186/s40200-017-0288-4
PMCID: PMC5260033
PMID: 28127543
eCollection 2018.
Hoshino J(1)(2), Furuichi K(3), Yamanouchi M(4), Mise K(5), Sekine A(1), Kawada
M(1), Sumida K(4), Hiramatsu R(4), Hasegawa E(1), Hayami N(4), Suwabe T(4), Sawa
N(4), Hara S(1), Fujii T(6), Ohashi K(7), Kitagawa K(8), Toyama T(3), Shimizu
Author information:
Okayama, Japan.
Kanagawa, Japan.
Ishikawa, Japan.
biopsy-proven Japanese patients with diabetic nephropathy (DN) were analyzed. The
(J-score) was calculated, whereupon its predictive ability for 10-year risk of
and 3 were 5, 5, and 4 (J-score range, 0-19). Renal survival curves, when
dividing into four J-score grades (0-5, 6-10, 11-15, and 16-19), were
significantly different from each other (p<0.01, log-rank test). After adjusting
Ability to predict 10-year renal outcome was improved when the J-score was added
DOI: 10.1371/journal.pone.0190923
PMCID: PMC5800536
192. J Biol Chem. 2016 Aug 26;291(35):18591-9. doi: 10.1074/jbc.C116.744037. Epub 2016
Jul 19.
Kim J(1), Lee HY(1), Ahn J(2), Hyun M(2), Lee I(2), Min KJ(1), You YJ(3).
Author information:
South Korea.
University, Richmond, Virginia 23298, and the Nagoya Research Center for Brain &
Japan yjyou@bio.nagoya-u.ac.jp.
Diabetes is one of the most impactful diseases worldwide. The most commonly
an unbiased screen in Caenorhabditis elegans The same NHE homolog also exists in
flies, where it too mediates the effects of metformin. Our results suggest that
endosomal NHEs could be a metformin target and provide an insight into a novel
DOI: 10.1074/jbc.C116.744037
PMCID: PMC5000102
Author information:
avinaash1381@gmail.com.
mlandstrom@brandeis.edu.
aluu@brandeis.edu.
kchayes@brandeis.edu.
high glycemic load, the ideal model should recapitulate the underlying dietary
issues. Most rodent models have three shortcomings: (1) they are genetically or
chemically modified to produce diabetes; (2) unlike humans, most require high-fat
feeding; (3) and they take too long to develop diabetes. By contrast, Nile rats
similar to humans, and are protected by high fat (with low glycemic load) intake.
This review describes diabetes progression in the Nile rat, including various
aspects of breeding, feeding, and handling for best experimental outcomes. The
disease progression; and kidney failure with chronic morbidity and death are
liver disease (NAFLD), also described in diabetic humans, results from hepatic
the nutritional factors and underlying genetic and molecular mechanisms that
DOI: 10.3390/nu10020235
PMCID: PMC5852811
Apr 19.
cholesterol indices in predicting diabetes risk for women with normal glucose
tolerance.
Liu L(1)(2)(3), Li Q(1)(2)(3), Yuan Z(4), Zhao M(1)(2)(3), Zhang X(1)(2)(3),
Author information:
China.
Australia, Australia.
MATERIALS AND METHODS: Of 3,653 middle-aged and elderly Chinese with normal
glucose tolerance at enrollment, 1,025 men and 1,805 women returned to the 3-year
follow up and were involved in the final analysis. Logistic regression analysis
was used to test the association between cholesterol indices and incident
RESULTS: Non-HDL was an independent risk factor for diabetes for women, but not
P = 0.002), whereas odds ratios for total cholesterol and low-density lipoprotein
cholesterol were 1.33 (95% confidence interval 1.06-1.67; P = 0.015) and 1.30
power and the optimal cut-off value of non-HDL for incident diabetes increased
across body mass index categories. For women with obesity, the threshold of
type 2 diabetes.
Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia,
Ltd.
DOI: 10.1111/jdi.12837
PMCID: PMC6215933
PMID: 29542288
195. Sensors (Basel). 2018 Sep 22;18(10). pii: E3208. doi: 10.3390/s18103208.
Lin YR(1)(2), Hung CC(3), Chiu HY(4)(5)(6)(7), Chang BH(8), Li BR(9)(10), Cheng
yoronglin@gmail.com.
yoronglin@gmail.com.
jhincihong19901008hy@gmail.com.
extra.owl0430@yahoo.com.tw.
Taiwan. extra.owl0430@yahoo.com.tw.
liborran@gmail.com.
shengjen@nctu.edu.tw.
jiawei@nctu.edu.tw.
jiawei@nctu.edu.tw.
linsf5402@nctu.edu.tw.
linsf5402@nctu.edu.tw.
guanyu@nctu.edu.tw.
Diabetes has become a chronic metabolic disorder, and the growing diabetes
and noninvasive contact lens as an ideal sensor for diabetes patients whose tear
fluid contains glucose. The key feature is the reversible covalent interaction
between boronic acid and glucose, which can provide a noninvasive glucose sensor
smartphone and analyzed using software. Our novel technique offers the following
capabilities: (i) non-enzymatic and continuous glucose detection with the contact
lens; (ii) no need for an embedded circuit and power source for the glucose
sensor; and (iii) the use of a smartphone to detect the change in thickness of
the contact lens with no need for additional photo-sensors. This technique is
DOI: 10.3390/s18103208
PMCID: PMC6210255
PMID: 30249021
Nutrient Patterns Associated with Fasting Glucose and Glycated Haemoglobin Levels
Chikowore T(1), Pisa PT(2), van Zyl T(3), Feskens EJ(4), Wentzel-Viljoen E(5)(6),
Conradie KR(7).
Author information:
nutrient patterns associated with the biomarkers of T2D is limited. This study
set out to determine the nutrient patterns associated with fasting glucose and
glycated haemoglobin the biomarkers of T2D. Factor analysis was used to derive
from the quantified food frequency questionnaires (QFFQ). Three nutrient patterns
per stratum, which accounted for 73% of the variation of the selected nutrients,
were identified. Multivariate linear regression models adjusted for age, BMI,
total energy intake were computed. Starch, dietary fibre and B vitamins driven
-0.047); p = 0.007) in rural women. Thiamine, zinc and plant protein driven
haemoglobin and fasting glucose ((β = -0.288 (-0.543; -0.033); p = 0.027) and (β
indicate that plant driven nutrient patterns are associated with low fasting
DOI: 10.3390/nu9010009
PMCID: PMC5295053
197. J Diabetes Res. 2016;2016:8610501. doi: 10.1155/2016/8610501. Epub 2016 Dec 25.
Nutritional Biomarkers, Gene-Diet Interaction, and Risk Factors for Type 2
Diabetes.
Zheng JS(1), Niu K(2), Jacobs S(3), Dashti H(4), Huang T(5).
Author information:
China.
Singapore.
DOI: 10.1155/2016/8610501
PMCID: PMC5220505
Author information:
(P.E.S., J.A.H.), Cell Biology (P.E.S.), and Cardiology and Molecular Biology
(P.E.S., J.A.H.), Cell Biology (P.E.S.), and Cardiology and Molecular Biology
DOI: 10.1161/CIRCRESAHA.116.308999
PMCID: PMC4888905
Dec 7.
Or KY(1), Yip BH(2), Lau CH(1), Chen HH(1), Chan YW(1), Lee KP(3).
Author information:
(2)Jockey Club School of Public Health and Primary Care, The Chinese University
(3)Jockey Club School of Public Health and Primary Care, The Chinese University
diabetes (DM) patients. Although interventions to reduce PIR have been suggested,
(for sample size calculation for larger trials), as well as the acceptability and
feasibility of this intervention group.
participants and lasted for 2 h each. The validated Chinese version of the
after, and 1 month after the intervention to measure any changes in the
RESULTS: Repeated measures ANOVA showed that the post-intervention C-ITAS scores
(immediately post group and at 1 month) were lower than the pre-intervention
C-ITAS scores (p < 0.001). Changes in multiple attitudes toward insulin were
detected before and after the group intervention. Ten patient interviews were
conducted and found that the intervention was welcomed by all interviewees; no
safe, acceptable, and effective in reducing PIR. Larger multicenter trials are
DOI: 10.1007/s13300-017-0347-3
PMCID: PMC5801233
PMID: 29218568
200. J Diabetes Res. 2016;2016:9145673. doi: 10.1155/2016/9145673. Epub 2016 Dec 29.
Perez Á(3), Martinez Carazo C(3), Arbonies Ortiz JC(4), Rua Portu MA(5), Piñera
Sanpedro T(9), Oses Portu A(10), Gorostidi Fano L(10), Aguirre Sorondo MB(11),
Author information:
Health Center, C/Marinos No. 1, Pasajes, San Pedro, 20110 Guipuzcoa, Spain.
Spain.
Spain.
Basque Health Service and offer initial estimations of the randomized controlled
single-arm pilot study with a 6-month follow-up period between February 2011 and
professionals, and the local media. Each intervention group consisted of 8-15
compliance with the course, and coordination and data collection issues were
evaluated. Glycated haemoglobin (HbA1c) was the main outcome variable. Secondary
quality of life, self-efficacy, physical exercise, and diet. Results. Two HCs did
not organize a course. A total of 173 patients initiated the program, 2 dropped
out without baseline data, and 90% completed it. No pre-post HbA1c differences
self-efficacy, physical activity, and some dietary habits. Conclusion. The SDSMP
is feasible in our setting. Our experience can be of interest when planning and
conducting this program in similar health settings. The trial is registered with
DOI: 10.1155/2016/9145673
PMCID: PMC5227166
Conflict of interest statement: The authors declare that they have no competing
interests.
201. J Epidemiol. 2018 Aug 5;28(8):347-352. doi: 10.2188/jea.JE20170048. Epub 2018 Mar
17.
A Point System for Predicting 10-Year Risk of Developing Type 2 Diabetes Mellitus
Yatsuya H(1)(2), Li Y(1), Hirakawa Y(2), Ota A(1), Matsunaga M(1), Haregot HE(2),
Chiang C(2), Zhang Y(2), Tamakoshi K(3), Toyoshima H(4), Aoyama A(2).
Author information:
School of Medicine.
BACKGROUND: Relatively little evidence exists for type 2 diabetes mellitus (T2DM)
prediction models from long-term follow-up studies in East Asians. This study
METHODS: We followed 3,540 male participants of Aichi Workers' Cohort Study, who
were aged 35-64 years and were free of diabetes in 2002, until March 31, 2015.
Baseline age, body mass index (BMI), smoking status, alcohol consumption, regular
exercise, medication for dyslipidemia, diabetes family history, and blood levels
blood glucose (FBG) were examined using Cox proportional hazard model. Variables
to the current dataset was compared to that obtained in the present study's
model.
RESULTS: During the median follow-up of 12.2 years, 342 incident T2DM cases were
documented. The prediction system using points assigned to age, BMI, smoking
status, diabetes family history, and TG and FBG showed reasonable discrimination
(c-index: 0.77) and goodness-of-fit (Hosmer-Lemeshow test, P = 0.22). The present
CONCLUSION: The point system, once validated in the other populations, could be
DOI: 10.2188/jea.JE20170048
PMCID: PMC6048299
White M(1).
Author information:
(1)Centre for Diet & Activity Research, MRC Epidemiology Unit, University of
DOI: 10.1371/journal.pmed.1002080
PMCID: PMC4942121
5.
Han L(1)(2), Shen WJ(1)(2), Bittner S(1), Kraemer FB(1)(2), Azhar S(1)(2).
Author information:
(1)Geriatrics Research, Education & Clinical Center, VA Palo Alto Health Care
subfamily consists of three members: PPAR-α, PPAR-β/δ and PPAR-γ. PPARs control
mellitus, nonalcoholic fatty liver disease and cardiovascular disease. The aim of
DOI: 10.2217/fca-2017-0019
PMCID: PMC5941699
Lucas Garcia EL(1)(2), Debensason D(3)(4), Capron L(3), Flahault A(3)(5), Pommier
J(6).
Author information:
emminarie.lucas-garcia@sncf.fr.
Switzerland.
body mass index (BMI) between 25 and 29.9 kg/m2, increases the risk of diabetes.
individuals is scarce. This study aims to identify factors that are associated
with elevated capillary blood glucose and can be routinely measured in French
analysis was used to examine factors associated with elevated capillary blood
glucose and results were described with odds ratios (OR) and 95% confidence
intervals (CI).
RESULTS: The analysis concerned 2248 overweight employees (mean age: 43 years)
with complete data (total population: 7724). The prevalence of elevated capillary
elevated capillary blood glucose were: male sex (OR 1.66, 95% CI 1.21-2.28),
age ≥ 50 years (OR 1.61, 95% CI 1.01-2.55), high blood pressure (OR 1.35, 95% CI
1.07-1.69), and daily intake of sugary food (OR 1.53, 95% CI 1.17-2.00). No
professional grade, and job sector) was found possibly due to lack of statistical
power.
prevention strategies in the workplace. Overweight men, aged 50 and older, with
high blood pressure and daily sugary food intake should be considered for
prevention strategies.
DOI: 10.1186/s12889-018-5384-y
PMCID: PMC5902963
PMID: 29661173
205. Int J Epidemiol. 2018 Apr 1;47(2):399-408. doi: 10.1093/ije/dyx228.
Prenatal famine exposure, adulthood obesity patterns and risk of type 2 diabetes.
Meng R(1), Lv J(1)(2), Yu C(1), Guo Y(3), Bian Z(3), Yang L(4), Chen Y(4), Zhang
H(5), Chen X(6), Chen J(7), Chen Z(4), Qi L(8)(9), Li L(1)(3); China Kadoorie
Author information:
(7)China National Center for Food Safety Risk Assessment, Beijing, China.
(8)School of Public Health and Tropical Medicine, Tulane University, New Orleans,
LA, USA.
about the joint effects of these risk factors at different stages of life on
Methods: The analysis included 88 830 participants of the China Kadoorie Biobank,
who were born around the time of the Chinese Great Famine and without diabetes,
identified 1372 incident cases of type 2 diabetes. Compared with nonexposed and
association between general obesity and diabetes was consistent across subgroups
between abdominal obesity and diabetes was observed in the fetal-exposed subgroup
interaction was more obvious in women (P = 0.013) but not in men (P = 0.699).
Compared with normal-BMI and -WHR participants, those with both general
these were carried during, before and after times of famine, respectively.
DOI: 10.1093/ije/dyx228
PMCID: PMC5913613
PMID: 29161448
Author information:
(1)Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard
Brian_Song@meei.harvard.edu.
near quadrupling in its worldwide prevalence since 1980. Though it has many known
evidence to suggest that diabetic patients have a greater risk for glaucoma as
diabetes and glaucoma appear to share some common risk factors and
diabetes and elevated fasting glucose levels are associated with elevated
While no study has completely addressed the possibility of detection bias, most
enriched with glaucoma patients. As the association between diabetes and glaucoma
DOI: 10.1007/s11892-016-0815-6
PMCID: PMC5310929
Mohamed SF(1)(2), Mwangi M(3)(4), Mutua MK(5), Kibachio J(4)(6), Hussein A(3)(4),
Author information:
(1)Health and Systems for Health Unit, African Population and Health Research
Nairobi, Kenya.
(5)Health and Systems for Health Unit, African Population and Health Research
causing about 4 million deaths in 2017. By 2040, low income countries are
diabetes poses a public health concern with costly public health implications
factors for diabetes at national level to inform policy and national programs.
METHODS: Data from the 2015 Kenya national STEPs survey of adults aged
18-69 years were used. Pre-diabetes was defined as impaired fasting blood glucose
level (6.1 mmol/l to < 7 mmol/l) while diabetes was defined as impaired fasting
blood glucose level ≥ 7 mmol/l. Descriptive statistics were used to determine the
RESULTS: Complete data for 4069 respondents (51% females), with 46% aged 18-29
and 61% in rural areas were analyzed. The age-standardized prevalence for
pre-diabetes and diabetes were 3.1% (95% CI: 2.2, 4.0) and 2.4% (1.8, 3.0)
respectively. Only 43.7% were aware of their glycemic condition, one in five of
those who had diabetes had received treatment, and only 7% of those diagnosed
with diabetes had their blood glucose under control. Primary education ((both
incomplete (0.21, 95%CI 0.10-0.47) and complete (0.40, 95%CI 0.23-0.71)) were
associated with lower odds of pre-diabetes. Older age (60-69 years, AOR; 5.6,
95%CI 2.1-15.1) and raised blood pressure (2.8, 95% CI 1.5-5.0) were associated
CONCLUSION: The overall diabetes prevalence in Kenya is consistent with what has
complications in the absence of interventions and the low diabetes awareness and
groups at risk of pre-diabetes and diabetes that can be targeted for screening,
DOI: 10.1186/s12889-018-6053-x
PMCID: PMC6218998
PMID: 30400865
eCollection 2017.
Prevalence and unmet need for diabetes care across the care continuum in a
national sample of South African adults: Evidence from the SANHANES-1, 2011-2012.
Stokes A(1), Berry KM(1), Mchiza Z(2), Parker WA(2), Labadarios D(2), Chola L(2),
Hongoro C(2), Zuma K(2), Brennan AT(1)(3), Rockers PC(1), Rosen S(1)(3).
Author information:
national surveillance is limited due to the lack of recent data. We used data
from the first comprehensive national survey on NCDs-the South African National
categorizing the population with diabetes into those who were unscreened,
screened but undiagnosed, diagnosed but untreated, treated but uncontrolled, and
Prevalence rates were higher among the non-white population and among women.
Among individuals with diabetes, a total of 45.4% were unscreened, 14.7% were
screened but undiagnosed, 2.3% were diagnosed but untreated, 18.1% were treated
but uncontrolled, and 19.4% were treated and controlled, suggesting that 80.6% of
the diabetic population had unmet need for care. The diabetes care cascade
unmet need for diabetes care in South Africa. Additionally, this analysis
DOI: 10.1371/journal.pone.0184264
PMCID: PMC5624573
Author information:
joao.almeidapedro@cisacaxito.org.
anthropometric characteristics.
METHODS: A total of 2 354 individuals were assessed for behavioural,
prevalence levels. Adjusted odds ratios for each variable related to the
RESULTS: Overall, the prevalence of hypertension was 18.0%, diabetes 9.2% and
was 48.5%; 15.8% were on treatment and 9.1% had their blood pressure controlled.
Only 10.8% were aware they had diabetes, 4.5% were on treatment and 2.7% were
controlled. The awareness level for hypercholesterolaemia was 4.2%, with 1.4%
CONCLUSION: The prevalence levels of hypertension and diabetes, which were higher
than previous findings for the region, together with the observed low rates of
additional challenge to the regional health structures, which must rapidly adapt
DOI: 10.5830/CVJA-2017-047
PMCID: PMC6008895
PMID: 29293258
Niiranen TJ(1), Lyass A(2), Larson MG(2), Hamburg NM(2), Benjamin EJ(2), Mitchell
(1)From the National Heart, Lung, and Blood Institute's and Boston University's
(G.F.M.). teemu.niiranen@thl.fi.
(2)From the National Heart, Lung, and Blood Institute's and Boston University's
(G.F.M.).
Comment in
vascular aging (HVA) in 3196 Framingham Study participants aged ≥50 years. We
defined HVA as absence of hypertension and pulse wave velocity <7.6 m/s (mean+2
SD of a reference sample aged <30 years). Overall, 566 (17.7%) individuals had
HVA, with prevalence decreasing from 30.3% in people aged 50 to 59 to 1% in those
aged ≥70 years. In regression models adjusted for physical activity, caloric
that lower age, female sex, lower body mass index, use of lipid-lowering drugs,
Simple 7) was associated with 1.55-fold (95% confidence interval, 1.38-1.74) age-
and sex-adjusted odds of HVA. During a follow-up of 9.6 years, 391 CVD events
occurred. In Cox regression models adjusted for traditional CVD risk factors,
including blood pressure, HVA was associated with a hazard ratio of 0.45 (95%
confidence interval, 0.26-0.77) for CVD relative to absence of HVA. Although HVA
normal vascular function beyond 70 years of age is challenging. Although our data
DOI: 10.1161/HYPERTENSIONAHA.117.09026
PMCID: PMC5509504
Zazo-Lázaro MP.
Author information:
Madrid, Spain.
(3)Grupo Respuesta Inmune Innata. Hospital La Paz Institute for Health Research
Madrid, Spain.
Spain.
Madrid, Spain.
with T2DM.
METHODS: We performed a large prospective cohort study of patients with T2DM from
the Madrid Diabetes Study. The first recruitment drive included 3443 patients.
The second recruitment drive included 727 new patients. Data have been collected
since 2007 (baseline visit) and annually during the follow-up period (since
2008).
21.5%) and was associated with previous personal history of depression (OR 6.482;
95% CI 5.138 to 8.178), mental health status below mean (OR 1.423; 95% CI 1.452
self-reported health status (OR 1.509; 95% CI 1.209 to 1.882), treatment with
oral antidiabetic agents plus insulin (OR 1.802; 95% CI 1.364 to 2.380), female
gender (OR 1.333; 95% CI 1.009 to 1.761) and blood cholesterol level (OR 1.005;
95% CI 1.002 to 1.009). The variables inversely associated with depression were:
being in employment (OR 0.595; 95% CI 0.397 to 0.894), low physical activity (OR
0.552; 95% CI 0.408 to 0.746), systolic blood pressure (OR 0.982; 95% CI 0.971 to
0.992) and social support (OR 0.978; 95% CI 0.963 to 0.993). In patients without
associated with several key diabetes-related outcomes. Our results suggest that
DOI: 10.1136/bmjopen-2017-020768
PMCID: PMC6157517
PMID: 30249627
AGES-Reykjavík study.
Author information:
(1)a The Department of Cardiology , Landspítali University Hospital , Reykjavík ,
Iceland.
the future.
DESIGN: Baseline characteristics and clinical data from 5706 individuals who
participated in the population based AGES-Reykjavik Study and gave their informed
consent were used. Their age range was 66-98 years (mean age 77.0 ± 5.9 years),
Iceland' institution on the current size, age and sex distribution of the
population and its prediction into the sixth decade were also used.
RESULTS: The prevalence of HF was 3.6% in the sexes combined, but higher in men
(5.1%) than women (2.7%) (p < .001). The prevalence of HF per age groups ≤69,
70-74, 75-79, 80-84 and ≥85 years was 1.7%, 1.5%, 3.7%, 5.2% and 7.2%,
distribution and increase in the number of elderly ≥70 years in the coming
decades, demonstrated that the number of patients with HF will have increased
the general population in a Nordic country, predicts that HF will be a major and
DOI: 10.1080/14017431.2017.1311023
PMCID: PMC5681737
Malawi.
Price AJ(1), Crampin AC(2), Amberbir A(3), Kayuni-Chihana N(4), Musicha C(4),
Tafatatha T(4), Branson K(5), Lawlor DA(6), Mwaiyeghele E(4), Nkhwazi L(4),
Smeeth L(7), Pearce N(7), Munthali E(4), Mwagomba BM(8), Mwansambo C(9), Glynn
Author information:
Malawi.
Comment in
lifestyle and other factors in Malawi, a very poor country with a predominantly
(≥18 years) residing in two defined geographical areas within Karonga District
and Lilongwe city. All adults self-defining as usually resident in the study
interviewed, had anthropometry and blood pressure measured, and had fasting blood
samples collected. The study outcomes were prevalence estimates and risk ratios
kg/m2) and obesity (BMI of 30·0 kg/m2 or more), and multimorbidity (two or more
FINDINGS: Between May 16, 2013, and Feb 8, 2016, we enrolled 15 013 (62%) of
24 367 eligible urban adults in Lilongwe and 13 878 (88%) of 15 806 eligible
diabetes were highly prevalent, more so in urban residents, the less poor, and
better educated than in rural, the poorest, and least educated participants. 18%
of urban men (961 of 5211 participants) and 44% (4115 of 9282) of urban women,
and 9% (521 of 5834) of rural men and 27% (2038 of 7497) of rural women were
overweight or obese; 16% (859 of 5212), 14% (1349 of 9793), 13% (787 of 5847),
and 14% (1101 of 8025) had hypertension; and 3% (133 of 3928), 3% (225 of 7867),
participants with diabetes, 233 (41%) were undiagnosed, and of 4096 participants
with hypertension, 2388 (58%) were undiagnosed. Fewer than half the participants
on medication for diabetes or hypertension had well controlled diabetes (84 [41%]
prevalent in urban and rural Malawi, yet many patients are undiagnosed and
targeted interventions are needed urgently to manage the already high burden.
Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access
article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights
reserved.
DOI: 10.1016/S2213-8587(17)30432-1
PMCID: PMC5835666
eCollection 2017.
Survey.
Keel S(1), Foreman J(1)(2), Xie J(1), van Wijngaarden P(1)(2), Taylor HR(3),
Dirani M(1).
Author information:
(1)Centre for Eye Research Australia, Royal Victorian Eye & Ear Hospital,
Melbourne, Australia.
Australia.
(3)Indigenous Eye Health Unit, Melbourne School of Population and Global Health,
RESEARCH DESIGN AND METHODS: 3098 non-Indigenous Australians aged 50-98 years and
increased markedly with age (OR = 1.04 per year, p = 0.017). Indigenous
Australians living in very remote areas were more likely to have self-reported
increase, the results of this national survey may inform future policy, planning
DOI: 10.1371/journal.pone.0169211
PMCID: PMC5207759
Conflict of interest statement: The National Eye Health Survey received funding
from a commercial source, Novartis Pharmaceuticals. This does not alter our
Chivese T(1)(2), Mahmoud W(1), Magodoro I(3), Kengne AP(4), Norris SA(2), Levitt
NS(5).
Author information:
risk factors for type 2 diabetes mellitus (T2DM), most particularly obesity. A
disease may affect the mother and the developing fetus. Apart from mapping the
childbearing age can help to galvanise targeted interventions for reducing the
burden of T2DM. This is a protocol for a systematic review aiming to assess the
METHODS AND ANALYSES: We will carry out a comprehensive literature search among a
African women of childbearing age (15-49 years) according to the WHO definition.
Full copies of articles identified through searches and considered to meet the
inclusion criteria will be obtained for data extraction and synthesis. The
analysis of the primary outcome (prevalent diabetes) will include two steps: (1)
and 95% CI for diabetes prevalence. We will assess heterogeneity and publication
bias using established methods. This systematic review will be reported according
ETHICS AND DISSEMINATION: Ethical approval is not required for this study, given
that this is a protocol for a systematic review, which utilises published data.
The findings of this study will be widely disseminated through peer reviewed
http://www.bmj.com/company/products-services/rights-and-licensing/.
DOI: 10.1136/bmjopen-2016-012255
PMCID: PMC5168695
2016.
Kahlert D(1), Unyi-Reicherz A(2), Stratton G(3), Meinert Larsen T(4), Fogelholm
Author information:
(2)Chair Exercise and Health Science, Stuttgart Research Initiative Human Factors
Germany.
Copenhagen, Denmark.
(5)Department of Food and Environmental Science, University of Helsinki Helsinki,
Finland.
BACKGROUND: Losing excess body weight and preventing weight regain by changing
components.
world by guiding them in changing their physical activity and dietary behavior
METHODS: The program development took five progressive steps, in line with the
Public Health Action Cycle: (1) Summing-up the intervention goal(s), target group
and the setting, (2) uncovering the generative psychological mechanisms, (3)
identifying behavior change techniques and tools, (4) preparing for evaluation
PMCID: PMC4978707
PMID: 27559319
Sato J(1), Kanazawa A(2)(3), Azuma K(1), Ikeda F(1), Goto H(1), Komiya K(1),
Kanno R(1), Tamura Y(1)(4), Asahara T(5)(6), Takahashi T(5)(6), Nomoto K(5)(6),
Author information:
113-8421, Japan.
reduce bacterial translocation and cause changes in the gut microbiota. Seventy
Japanese patients with type 2 diabetes were randomised to two groups: the
the control group ingested no probiotics. The trial was conducted for 16 weeks.
At baseline, 8 and 16 weeks, the gut microbiota composition in feces and blood,
fecal organic acids, and other biochemical parameters were measured. At the end
of the study, the fecal counts of the Clostridium coccoides group and Clostridium
leptum subgroup in the probiotic group were significantly higher than in the
blood bacteria was significantly lower in the probiotic group. However, fecal
organic acids were comparable between the two groups. Our results showed that
DOI: 10.1038/s41598-017-12535-9
PMCID: PMC5608749
PMID: 28935921
218. Health Qual Life Outcomes. 2017 Jul 14;15(1):142. doi: 10.1186/s12955-017-0717-6.
Profile and predictors of health related quality of life among type II diabetes
Pakistan.
mohammad.bashaar@yahoo.com.
analysis. 300 Type II diabetic patients attending public and private hospitals
were targeted for data collection. In addition to demographic and disease related
information, Euroqol Quality of Life was used to measure HRQoL. Moreover, Drug
Attitude Inventory and Michigan Diabetes Knowledge Test were used to assess
HRQoL. SPSS v. 20 was used for data analysis and p < 0.05 was taken as
significant.
RESULTS: Patients in the current study reported poor HRQoL with a mean score of
with HRQoL in the cross tabulation analysis. The significant variables were
entered into the model that showed significant goodness of fit with highly
with an increase of one adherence score was associated with improvement of HRQoL
behavior and should put their efforts in explaining the benefits of the
DOI: 10.1186/s12955-017-0717-6
PMCID: PMC5512812
2017.
Pascoe MC(1)(2), Thompson DR(3)(4), Castle DJ(3)(5), Jenkins ZM(5), Ski CF(3)(5).
Author information:
they have not been assessed using meta-analysis. The purpose of this
meta-analysis of randomized controlled trials is to investigate the effects of
Pubmed, MEDLINE, CINAHL, PsycINFO, Scopus, Web of Science and SocINDEX were
usual care. Study selection was completed using Covidence and meta-analysis was
symptoms (SMD: -0.70; CI: -1.27, -0.13) which persisted at follow up (SMD: -1.54,
CI: -2.97, -0.12). Similar results were not seen immediately post-intervention in
the three studies that assessed anxiety symptoms (SMD: -0.30; CI: -0.69, 0.10);
-0.92 to -0.31). Small benefits were seen in the three studies assessing quality
of life outcomes (SMD: 0.30, CI: 0.06, 0.55). No benefit was seen in the two
studies assessing self-efficacy (SMD: 0.23, CI: -0.11, 0.57). Conclusions: The
improve quality of life in individuals with diabetes. However, only a few studies
DOI: 10.3389/fpsyg.2017.02063
PMCID: PMC5723413
PMID: 29259563
thermal stimuli.
Plumb AA(1), Huynh NT(2), Guggenheim J(2), Zhang E(2), Beard P(2).
Author information:
Podium Level 2, 235 Euston Road, London, NW1 2BU, UK. andrew.plumb@nhs.net.
dorsalis pedis (DP) artery, and 13 completed PAI of the index fingertip. Finger
images were obtained after immersion in warm (30-35 °C) or cold (10-15 °C) water
RESULTS: Fingertip vessels were visible in all participants, with mean FWHM of
125 μm. Two radiologists used PAI to correctly identify vasoconstricted fingertip
capillary beds with 100% accuracy (95% CI 77.2-100.0%, p < 0.001). The number of
voxels exhibiting vascular signal was significantly smaller after cold water
immersion (cold: 5263 voxels; warm: 363,470 voxels, p < 0.001). The DP artery was
visible in 7/8 participants (87.5%).
correct identification rate, p < 0.001). • Vessels measuring less than 100 μm in
DOI: 10.1007/s00330-017-5080-9
PMCID: PMC5811589
Mar 23.
Author information:
AIMS/INTRODUCTION: Social engagement can positively affect health status, but its
effect on diabetes incidence remains unclear. The present study aimed to assess
MATERIALS AND METHODS: We analyzed data on 31,615 people aged 50-59 years from a
prospective national survey carried out in Japan from 2005 to 2013. Diabetes
incidence was measured by asking respondents annually whether they had been
Covariates including sex, age, health status and health behaviors were also
measured at baseline.
RESULTS: After adjusting for covariates measured at baseline, the effect size of
social engagement on diabetes incidence was the same as or larger than that of
[HR] 0.89, 95% confidence interval [CI] 0.87-0.92), had the companionship of
friends (HR 0.97, 95% CI: 0.95-1.00), lived with someone (HR 0.85, 95% CI:
0.82-0.89) and were employed (HR 0.94, 95% CI: 0.92-0.96) were significantly less
strategies to prevent diabetes in Japan should focus on both social and personal
factors.
Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia,
Ltd.
DOI: 10.1111/jdi.12820
PMCID: PMC6123021
PMID: 29430865
222. PLoS One. 2017 Nov 30;12(11):e0188650. doi: 10.1371/journal.pone.0188650.
eCollection 2017.
Relative muscle mass and the risk of incident type 2 diabetes: A cohort study.
Hong S(1), Chang Y(1)(2)(3), Jung HS(1), Yun KE(1), Shin H(1)(4), Ryu S(1)(2)(3).
Author information:
(1)Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital,
AIMS: The association between relative muscle mass (RMM) and incidence of type 2
METHODS: This cohort study was comprised of 113,913 men and 89,854 women, free of
T2DM at baseline, who underwent a health checkup examination and were followed-up
annually or biennially for an average of 2.9 years. We used skeletal muscle mass
index (SMI) as an indicator of RMM. SMI (%) [total skeletal muscle mass (kg)/body
study outcome was incident T2DM, defined as fasting serum glucose ≥126 mg/dL,
T2DM (incidence rate, 7.2 per 1000 person-years). Median age (range) at baseline
was 39.1 years (18.1-87.1). RMM was negatively associated with incidence of T2DM
1.32 (1.14-1.52), 1.63 (1.42-1.86), and 2.21 (1.94-2.51), respectively, for males
and 1.18 (0.88-1.58), 1.46 (1.11-1.91), and 1.96 (01.51-2.53) for females (P for
subjects.
risk of T2DM.
DOI: 10.1371/journal.pone.0188650
PMCID: PMC5708784
the case for repeat application as a novel therapy for lower extremity
ulceration.
Author information:
transferred to a remote organ via humoral and neural pathways. The diabetic state
Despite this, studies utilising ischaemic conditioning and RIC in type 2 diabetes
have often been disappointing. A newer strategy, repeat RIC, involves the
ulcers. This article summarises the mechanisms of RIC, and the impact that type 2
diabetes may have upon these, with the role of neural mechanisms in the context
of diabetic neuropathy a focus. Repeat RIC may show more promise than RIC in type
2 diabetes, and its potential mechanisms and applications will also be explored.
resulting from diabetic lower extremity ulceration, repeat RIC has the potential
DOI: 10.1186/s12933-016-0444-z
PMCID: PMC5018170
2017.
2 Diabetes Mellitus.
Esaki H(1)(2), Tachi T(1)(3), Goto C(3), Sugita I(1), Kanematsu Y(1), Yoshida
A(1), Saito K(1), Noguchi Y(1), Ohno Y(3), Aoyama S(3), Yasuda M(3), Mizui T(3),
Author information:
Gifu, Japan.
investigated temporal changes in the renal function index of patients with type 2
diabetes mellitus (DM) and examined the influence of DPP-4 inhibitors on renal
function. Patients with type 2 DM (>18 years old) prescribed hypoglycemic agents
at Gifu Municipal Hospital for ≥3 months between March 2010 and April 2014 were
included in the study. Renal function was evaluated as estimated the decline in
12-month glomerular filtration rate from the baseline in patients receiving and
not receiving DPP-4 inhibitors. Patient data from the DPP-4 inhibitor-treated
(501 patients, 58.6%) and untreated (354, 41.4%) groups were analyzed using
regression analysis (616, 55.6% and 491, 44.4%, for DPP-4 inhibitors-treated and
decline [20% over 12 months; odds ratio (OR), 0.626; 95% confidence interval
DOI: 10.3389/fphar.2017.00835
PMCID: PMC5694778
PMID: 29187821
Ang GY(1).
Author information:
once it has been diagnosed. The objective of this narrative review is to review
stronger for type 2 diabetes patients compared with type 1 diabetes patients. It
is also unclear whether non obese diabetes patients would benefit from such
Further research is needed in this area especially with regards to the subgroup
of diabetes patient who will benefit from these interventions and the long term
safety and efficacy remains unknown especially with intensive medical management.
DOI: 10.4239/wjd.v9.i7.127
PMCID: PMC6068740
PMID: 30079148
conflicts of interest.
eCollection 2018.
Author information:
Pakistan.
Islamabad, Pakistan.
Vancouver, Canada.
MATERIALS AND METHODS: This prospective cohort study recruited new patients of
pulmonary tuberculosis (PTB) aged 15 years and above who were diagnosed at and
registered with Gulab Devi Chest Hospital, Lahore, Pakistan for anti-tuberculosis
treatment (ATT). PTB patients were screened for diabetes using random and fasting
blood glucose tests. Diabetic and non-diabetic PTB patients were followed up at
second, fifth and sixth month of ATT and 6 months after ATT completion to
RESULTS: Of 614 PTB patients, (n = 113 [18%]) were diabetic and (n = 501 [82%])
non-diabetic. Final model showed that diabetics were more likely to experience an
unfavorable outcome included rural residence (aOR = 1.98, 95% CI = 1.14 to 3.47),
body mass index less than 18.50 (aOR = 1.89, 95% CI = 1.03 to 3.47) and being a
CONCLUSION: Our study shows unfavorable treatment outcome among diabetic PTB
DOI: 10.1371/journal.pone.0207148
PMCID: PMC6224090
PMID: 30408109
interests exist.
227. J Mol Endocrinol. 2018 Jul;61(1):R43-R60. doi: 10.1530/JME-18-0011. Epub 2018 Apr
16.
The role of beta cell heterogeneity in islet function and insulin release.
Nasteska D(1)(2)(3), Hodson DJ(4)(2)(3).
Author information:
Edgbaston, UK.
Birmingham, UK.
MidlandsBirmingham, UK.
Edgbaston, UK d.hodson@bham.ac.uk.
are equal. Subtle differences exist at the transcriptomic and protein expression
beta cell failure during T2DM in both rodents and humans. The present review will
discuss the molecular and cellular features of beta cell heterogeneity at both
the single-cell and islet level, explore how this influences islet function and
insulin release and look into the alterations that may occur during obesity and
T2DM.
DOI: 10.1530/JME-18-0011
PMCID: PMC5976077
PMID: 29661799
228. Nutrients. 2017 Oct 10;9(10). pii: E1104. doi: 10.3390/nu9101104.
Chinese Men and Women with Prediabetes or Early Untreated Diabetes-A Randomized
Controlled Trial.
Yang L(1), Ling W(2), Yang Y(3), Chen Y(4), Tian Z(5), Du Z(6), Chen J(7), Xie
Author information:
China. yanglp6@mail2.sysu.edu.cn.
China. lingwh@mail.sysu.edu.cn.
China. yangyan3@mail.sysu.edu.cn.
China. shishujushi@sina.com.
xinling_3@aliyun.com.
China. yangll7@mail.sysu.edu.cn.
Objective: In vitro and animal studies suggest that purified anthocyanins have
among individuals with prediabetes. The aim of this study was to investigate
Chinese adults with early untreated hyperglycemia. Research Design and Methods:
160 participants aged 40-75 years with prediabetes or early untreated diabetes
hemoglobin A1c (HbA1c), fasting and postprandial glucose, insulin, C-peptide, and
lipids) were measured at baseline and at the end of the trial. Results: A total
apolipoprotein A-1 (apo A1) (0.09 g/L, 95% CI: 0.02~0.17; p = 0.02), and
favorably affected glycemic control and lipid profile. Future studies of a longer
PMCID: PMC5691720
claim.
The roles, training and knowledge of community health workers about diabetes and
Author information:
BACKGROUND: The current roles and capacity of community health workers (CHWs) in
understood.
OBJECTIVES: To assess CHWs' current roles, training and knowledge about diabetes
was used to determine the roles, training, in-service support, knowledge and
of the factors associated with CHWs' knowledge of hypertension and diabetes were
conducted.
RESULTS: The vast majority (96%) of CHWs were female, with a mean age of 35
years; 88% had some secondary schooling and 53% had been employed as CHWs for 4
years or more. Nearly half (47%) reported having an NCD. CHWs' roles in NCDs
Only 52% of CHWs reported some formal NCD-related training, while less than half
of the trained CHWs (n = 35; 44%) had received follow-up refresher training.
analyses, higher knowledge scores were associated with having an NCD and
CONCLUSIONS: The roles performed by CHWs are broad, varied and essential for
diabetes and hypertension management. However, basic knowledge about diabetes and
DOI: 10.4102/curationis.v41i1.1815
PMCID: PMC6091590
PMID: 29781697
Peykari N(1), Hashemi H(1), Asghari G(2), Ayazi M(3), Janbabaei G(4), Malekzadeh
R(5), Raeisi A(6), Sadrolsadat A(7), Asadi-Lari M(8), Farshad A(9), Farzadfar
F(10), Ghanei M(11), Haghdoost AA(12), Heshmat R(13), Jamshidi H(14), Ostovar
Author information:
(1)Iranian Non Communicable Diseases Committee (INCDC), Ministry of Health and
(2)Food and Drug Organization, INCDC, Ministry of Health and Medical Education,
Tehran, Iran.
(3)Social Health Deputy, INCDC, Ministry of Health and Medical Education, Tehran,
Iran.
Tehran, Iran.
(6)Public Health Deputy, INCDC, Ministry of Health and Medical Education, Tehran,
Iran.
Tehran, Iran.
Tehran, Iran.
urgent actions across the world. Scientific evidence is the critical arm for
collaboration.
cancers, diabetes, and chronic respiratory diseases were carried out through the
assessed, and the frequently used terms on noncommunicable diseases were mapped
by VOSviewer software.
Results: Over the 17 years, 25827 articles about four main NCDs by Iran indexed
respiratory publications have slow trend. The number of articles, citations, and
was USA in the four areas, and there was not seen region countries' collaboration
in top ten levels. The frequently used terms in NCDs' articles in order were
PMCID: PMC6119576
PMID: 30181990
Conflict of interest statement: Conflict of Interest The authors declare that
Yu SS(1), Du JL(2).
Author information:
tissues and organs: it exerts antioxidant protection and has anti-ER stress
effects in the pancreas and blood vessels, while it promotes the occurrence and
muscle. In addition, studies have confirmed that some SELENOS gene polymorphisms
can influence the inflammatory response and are closely associated with the risk
the association between SELENOS and inflammation, oxidative stress, and ER stress
DOI: 10.1186/s12933-017-0585-8
PMCID: PMC5553675
232. Nat Biomed Eng. 2017 Jan;1(1):0005. doi: 10.1038/s41551-016-0005. Epub 2016 Dec
19.
Ye H(#)(1)(2), Xie M(#)(1), Xue S(2), Charpin-El Hamri G(3), Yin J(2), Zulewski
Author information:
Sciences and School of Life Sciences, East China Normal University, Dongchuan
Switzerland.
(#)Contributed equally
self-adjusting synthetic gene circuit can be designed to sense and reverse the
metabolic disorders.
DOI: 10.1038/s41551-016-0005
PMCID: PMC5412959
PMID: 28480128
Self-reported diabetes during pregnancy in the South African National Health and
Author information:
Council, HSRC Building, 134 Pretorius Street, Pretoria, 0002, South Africa.
LChola@hsrc.ac.za.
Council, HSRC Building, 134 Pretorius Street, Pretoria, 0002, South Africa.
Africa, but its prevalence and distribution in pregnant women is not well known.
Women diagnosed with diabetes during pregnancy have a substantially greater risk
of adverse health outcomes for both mother and child. This study aims to
South Africa.
METHODS: Data used in this study were from the 2012 South African National
cross-sectional household survey. The analysis was restricted to girls and women
obesity.
RESULTS: The prevalence of diabetes during pregnancy in South Africa was 3% (144
women) of all women who reported ever being pregnant. The majority of the women
who had ever had diabetes were African (70%), 51% were unemployed and 76% lived
in rural areas. Factors strongly associated with diabetes during pregnancy were
age (1.04 [Odds Ratio], 0.01 [Standard Error]), family history of diabetes (3.04;
diabetes during pregnancy and its social determinants. This will help in the
DOI: 10.1186/s12884-016-1218-z
PMCID: PMC5223373
Jun 15.
Analysis.
Carlsson Petri KC(1), Ingwersen SH(2), Flint A(2), Zacho J(2), Overgaard RV(2).
Author information:
KCC@NovoNordisk.com.
were enrolled in one of five trials in the phase III development program for
RESULTS: No clinically relevant effects on the exposure were seen for sex, age,
race, ethnicity, renal function, or injection site used, and semaglutide exposure
was stable over time. Of the covariates chosen, only body weight had a relevant
was shown for the 0.5 mg and 1.0 mg maintenance doses of semaglutide.
is not affected by covariates other than body weight at either a maintenance dose
NCT02207374).
DOI: 10.1007/s13300-018-0458-5
PMCID: PMC6064581
PMID: 29907893
235. Korean J Fam Med. 2018 Sep;39(5):313-317. doi: 10.4082/kjfm.17.0122. Epub 2018
Jul 31.
Serum Branched Chain Amino Acids Are Associated with Type 2 Diabetes Mellitus in
Jordan.
Alfaqih MA(1), Abu-Khdair Z(1), Saadeh R(1), Saadeh N(1), Al-Dwairi A(1),
Al-Shboul O(1).
Author information:
Jordan.
the lack of insulin secretion (type 1) or resistance to its action (type 2). A
relationship has not been assessed in Jordan. The objective of this study was to
investigate the association between serum branched chain amino acids and type 2
METHODS: Two hundred type 2 diabetes mellitus patients and an additional 200
non-diabetic controls were recruited. Age, body mass index, and waist
circumference of the subjects were recorded. Branched chain amino acid, total
cholesterol, and triglyceride levels were measured from the collected serum
samples.
RESULTS: Serum branched chain amino acid levels were significantly higher in type
binomial regression analysis, serum branched chain amino acid levels remained
significantly associated with diabetes mellitus and increased its risk (odds
amino acid levels in Jordan independent of age, sex, body mass index, waist
DOI: 10.4082/kjfm.17.0122
PMCID: PMC6166113
PMID: 30060645
236. Diabet Med. 2018 Jul;35(7):862-870. doi: 10.1111/dme.13613. Epub 2018 Mar 15.
Setting the top 10 research priorities to improve the health of people with Type
Finer S(1), Robb P(2), Cowan K(2), Daly A(3), Shah K(4), Farmer A(5).
Author information:
(1)Centre for Primary Care and Public Health, Blizard Institute, Barts and the
London School of Medicine and Dentistry, Queen Mary University of London, London.
Oxford, UK.
survey distributed to 70 000 people living with Type 2 diabetes and their carers,
technique. At each step the steering group closely monitored and guided the
process.
participants, of whom 18% were from black, Asian and minority ethnic groups.
Uncertainties were formatted and collated into 114 indicative questions. A total
and their carers and those of healthcare professionals. In the final step the
Type 2 diabetes.
and strategic allocation of research resources, and improve the future health and
© 2018 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on
DOI: 10.1111/dme.13613
PMCID: PMC6032840
PMID: 29485717
237. Int J Endocrinol. 2017;2017:6039356. doi: 10.1155/2017/6039356. Epub 2017 Feb 20.
Ballotari P(1), Venturelli F(2), Greci M(3), Giorgi Rossi P(1), Manicardi V(4).
Author information:
(3)Primary Care Department, Local Health Authority of Reggio Emilia, Via Amendola
The aim of the study is to assess sex difference in association between type 2
register. The inhabitants of Reggio Emilia (Italy) aged 30-84 were followed
during 2012-2014. Incidence rate ratios and 95% confidence intervals were
calculated using multivariate Poisson model. The age- and sex-specific event
rates were graphed. Subjects with type 2 diabetes had an excess risk compared to
their counterparts without diabetes for all the three major cardiovascular
events. The excess risk is similar in women and men for stroke (1.8 times) and
heart failure (2.7 times), while for myocardial infarction, the excess risk in
women is greater than the one observed in men (IRR 2.58, 95% CI 2.22-3.00 and IRR
1.78, 95% CI 1.60-2.00, resp.; P of interaction < 0.0001). Women had always a
lesser risk than men, but in case of myocardial infarction, the women with type 2
diabetes lost part of advantage gained by women free of diabetes (IRR 0.61, 95%
CI 0.53-0.72 and IRR 0.36, 95% CI 0.33-0.39, resp.). In women with type 2
DOI: 10.1155/2017/6039356
PMCID: PMC5338069
PMID: 28316624
Conflict of interest statement: The authors declare that there is no conflict of
prospective studies.
De Bacquer D, Dobson AJ, Criqui MH, Jacobs DR Jr, Leon DA, Peters S, Ueshima H,
Imai Y, Iso H, Jackson R, Jamrozik K, Jee SH, Jensen G, Jiang CQ, Johansen NB,
Wannamethee SG, Welborn TA, Whincup P, Whitlock G, Willett W, Woo J, Wu ZL, Yao
BACKGROUND: Several studies have shown that diabetes confers a higher relative
risk of vascular mortality among women than among men, but whether this increased
relative risk in women exists across age groups and within defined levels of
established risk factors, such as blood pressure, BMI, smoking, and cholesterol,
explain the higher relative risks of vascular mortality among women than among
men.
studies included in the Prospective Studies Collaboration and the Asia Pacific
Cohort Studies Collaboration that had obtained baseline information on age, sex,
diabetes, total cholesterol, blood pressure, tobacco use, height, and weight.
Data on causes of death were obtained from medical death certificates. We used
Cox regression models to assess the relevance of diabetes (any type) to occlusive
atherosclerotic deaths) by age, sex, and other major vascular risk factors, and
vascular disease. After controlling for major vascular risk factors, diabetes
roughly doubled occlusive vascular mortality risk among men (death rate ratio
[RR] 2·10, 95% CI 1·97-2·24) and tripled risk among women (3·00, 2·71-3·33; χ2
test for heterogeneity p<0·0001). For both sexes combined, the occlusive vascular
death RRs were higher in younger individuals (aged 35-59 years: 2·60, 2·30-2·94)
than in older individuals (aged 70-89 years: 2·01, 1·85-2·19; p=0·0001 for trend
across age groups), and, across age groups, the death RRs were higher among women
than among men. Therefore, women aged 35-59 years had the highest death RR across
all age and sex groups (5·55, 4·15-7·44). However, since underlying
men than in women, the adjusted absolute excess occlusive vascular mortality
associated with diabetes was similar for men and women. At ages 35-59 years, the
excess absolute risk was 0·05% (95% CI 0·03-0·07) per year in women compared with
0·08% (0·05-0·10) per year in men; the corresponding excess at ages 70-89 years
was 1·08% (0·84-1·32) per year in women and 0·91% (0·77-1·05) per year in men.
Total cholesterol, blood pressure, and BMI each showed continuous log-linear
substantially increased vascular risk in both men and women. Lifestyle changes to
reduce smoking and obesity and use of cost-effective drugs that target major
vascular risks (eg, statins and antihypertensive drugs) are important in both men
and women with diabetes, but might not reduce the relative excess risk of
UK, European Union BIOMED programme, and National Institute on Aging (US National
Institutes of Health).
Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access
article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights
reserved.
DOI: 10.1016/S2213-8587(18)30079-2
PMCID: PMC6008496
PMID: 29752194
239. Front Endocrinol (Lausanne). 2017 Oct 4;8:263. doi: 10.3389/fendo.2017.00263.
eCollection 2017.
Menon K(1), Mousa A(1), de Courten MP(2), Soldatos G(1), Egger G(3), de Courten
B(1).
Author information:
(1)Monash Centre for Health Research and Implementation, School of Public Health
Australia.
(3)Centre for Health Promotion and Research, Health and Human Sciences
Type 2 diabetes mellitus (T2DM) is a complex chronic disease affecting over 400
education are delivered in a single session. SMAs allow physicians to deliver the
same level of care to multiple patients at the same time, thereby maximizing
management of T2DM remains unknown. This narrative review summarizes current and
outcomes in patients with T2DM, as well as whether SMAs are associated with
reduced costs and improved diabetes-related behavioral and lifestyle changes. An
PubMed and Google Scholar using keywords, including SMAs, group visits, and T2DM
to identify all studies of SMAs in patients with T2DM. Studies in type 1 diabetes
did not involve a physician since these do not meet the classical definition of a
SMA. Nineteen studies were identified and are included in this review. Overall,
current evidence suggests that SMAs delivered regularly over time may be
the paucity of comparisons with standard care which limits the ability to draw
setting. We conclude that there remains a need for larger studies to identify
populations who may or may not benefit from the SMA model of care and to clarify
the potential benefits and barriers to implementing SMAs into routine diabetes
care.
DOI: 10.3389/fendo.2017.00263
PMCID: PMC5632846
PMID: 29046662
Clackamas, OR, and the Center for Health Research in Portland, OR, and former
Visiting Scientist at the Galil Center for Telemedicine, Medical Informatics and
william.vollmer@kpchr.org.
greg.nichols@kpchr.org.
CONTEXT: Given the dramatic rise in the incidence of type 2 diabetes mellitus
prevention efforts.
DESIGN: Observational study of more than 77,000 adult members (age 18-75 years)
from 3 Regions of the Kaiser Foundation Health Plan with prediabetes (hemoglobin
RESULTS: The 2-year risk of diabetes diagnosis varied widely by HbA1C and BMI. A
small subset (5.2%) had a very high risk of T2DM developing within 2 years.
Another 13.3% had a moderate 2-year risk of T2DM, whereas most (81.5%) of the
population was at much lower risk. Thus, most Kaiser Foundation Health Plan
members with prediabetes have only modest risk of progression to T2DM within 2
years.
CONCLUSION: Using HbA1C and BMI, we created a simple stratification scheme to
more precisely estimate risk of T2DM incidence. This will enable more efficient
the small subset at highest risk, while minimizing the potentially negative
effects of overdiagnosis among the majority with prediabetes who are not at high
DOI: 10.7812/TPP/17-050
PMCID: PMC5760055
PMID: 29309270
2018.
Propensity-Matching Study.
Lin SY(1)(2), Hsu WH(1)(3), Lin CC(1)(4), Lin CL(5)(6), Tsai CH(1)(7), Yeh HC(1),
Author information:
Taiwan.
Taiwan.
Taichung, Taiwan.
Taiwan.
Taichung, Taiwan.
included 1,578 patients aged 20 years and above. The nonsitagliptin cohort
outcome was the incidence of fractures, which was evaluated using Kaplan-Meier
survival analysis and proportional hazards modeling. Results: The mean age of
patients in the sitagliptin and nonsitagliptin cohorts was 63.1 and 63.3 years,
1,000 person-years and that in the nonsitagliptin cohort was 40.8 per 1,000
sitagliptin cohort who received sitagliptin for ≥250 days had a higher risk of
fracture (aHR = 1.32, 95% CI = 1.06-1.64). Conclusion: Using sitaglipin ≥250 days
DOI: 10.3389/fphar.2018.00677
PMCID: PMC6025224
PMID: 29988467
242. Sci Rep. 2017 Jan 27;7:41518. doi: 10.1038/srep41518.
Wu J(1), Xu H(2), He X(1), Yuan Y(3), Wang C(1), Sun J(1), He S(1), Niu J(2).
Author information:
population aged 20-75 years in 2007 and 2013 in Jilin, China. A total of 3636
(1719 males) and 1359 (602 males) participants were enrolled in the 2007 and 2013
dyslipidemia and NAFLD increased from 2007 to 2013 from 15.82% to 19.41%, 35.85%
44.31% in males, respectively, and from 13.18% to 18.77%, 31.11% to 37.54%, 4.41%
38.10% vs. 38.63% and females: 33.04% vs. 33.01% in 2007 and 2013, respectively).
DOI: 10.1038/srep41518
PMCID: PMC5269745
interests.
Socioeconomic inequality in morbid obesity with body mass index more than
Author information:
(1)Department of Primary Care and Public Health Sciences, King's College London,
UK.
(body mass index, BMI ≥40 kg/m2) through an analysis of population health survey
Methods: We analysed data for the National Health and Nutrition Examination
Survey and the Health Survey for England for 2011 to 2014. Age-adjusted odds
Results: There were 26,898 eligible UK and 10,628 US participants. Morbid obesity
was more frequent in women than men, and higher in the US than the UK (men: US,
4.8%; UK, 1.7%; women US, 9.6%; UK, 3.7%). In the UK, morbid obesity showed
graded income-inequality in both genders (AOR, for lowest income quintile: men,
1.83, 95% confidence interval 1.16 to 2.88; women, 2.18, 1.55 to 3.07), as well
4.02; women, 2.18, 1.55 to 3.07). In the US, morbid obesity showed a consistent
gradient only for income in women (AOR for lowest income quintile 1.97, 1.19 to
3.25). When compared with all other US groups, having college education (AOR,
men, 0.56, 0.29 to 1.08; women, 0.36, 0.22 to 0.60) or household income ≥$75 000
(AOR, men 0.52, 0.27 to 0.98; women, 0.51, 0.33 to 0.80) appeared to protect
and women in the UK. In the US, morbid obesity was twice as prevalent, but less
strongly associated with socioeconomic status, suggesting that morbid obesity may
DOI: 10.1016/j.ssmph.2016.12.012
PMCID: PMC5769007
PMID: 29349213
Author information:
that this situation will continue until at least 2030. Type 2 diabetes has been
reported to be more prevalent among people with low socioeconomic status (SES) in
high-income countries, whereas the opposite pattern has been found in studies
RESULTS: Thirty-three studies met the inclusion criteria and were included in the
systematic review. The association between education, income and occupation and
type 2 diabetes was reported by 27, 19 and 12 studies, respectively. Most, but
not all, studies reported an inverse association between education and type 2
diabetes, with odds ratios (OR) and 95% confidence interval (CI) ranging from
0.39 (CI not reported) to 1.52 (95% CI 0.91 - 2.54) for the highest compared to
the lowest education level. The association between income and type 2 diabetes
and people working in white collar jobs were reported to have a higher risk of
type 2 diabetes than other occupational groups even after adjusting for age.
SES and prevalence of type 2 diabetes in China found that low education is
PMCID: PMC5481892
and on the Scottish Diabetes Register from Novo Nordisk. All authors have
10.4103/ijem.IJEM_85_17.
Goal.
Gupta V(1), Canovatchel W(2), Lokesh BN(3), Santani R(3), Garodia N(3).
Author information:
India.
that extend beyond the role of insulin and glucose utilization have been crucial
undesirable effects on common risk factors such as weight gain and cardiovascular
to the array of therapeutic agents for T2DM that have demonstrated robust
glycemic control as mono and add-on therapies. Their unique renal mode of action,
virtue of these effects, SGLT2i may have a distinct role in the revised treatment
targets. The current review gives an overview of the changing treatment needs for
promoting weight loss, stabilizing blood pressure, and other favorable metabolic
effects.
DOI: 10.4103/ijem.IJEM_85_17
PMCID: PMC5729683
PMID: 29285458
LLC, USA, and holds company stocks. Dr. Vishal Gupta has received honoraria as a
consultant from Janssen India. Dr. B. N. Lokesh was an employee of Janssen India
at the time of conception of this review article. Dr. Ravi Santani was an
[with or without additional support from lay lifestyle mentors with Type 2
diabetes] to prevent transition to Type 2 diabetes in high risk groups with non -
Pascale M(1)(2), Murray N(1)(2), Bachmann M(3), Barton G(4)(5), Clark A(5)(6),
Author information:
(1)Norfolk Diabetes Prevention Study, Norfolk and Norwich University Hospital NHS
Norfolk and Norwich University Hospital NHS Trust, Norwich, NR4 7UY, UK.
Norwich, UK.
(8)Norfolk Diabetes Prevention Study, Norfolk and Norwich University Hospital NHS
Norfolk and Norwich University Hospital NHS Trust, Norwich, NR4 7UY, UK.
mike.sampson@nnuh.nhs.uk.
BACKGROUND: This 7 year NIHR programme [2011-2018] tests the primary hypothesis
that the NDPS diet and physical activity intervention will reduce the risk of
transition to type 2 diabetes (T2DM) in groups at high risk of Type 2 diabetes.
The NDPS programme recognizes the need to reduce intervention costs through group
delivery and the use of lay mentors with T2DM, the realities of normal primary
care, and the complexity of the current glycaemic categorisation of T2DM risk.
METHODS: NDPS identifies people at highest risk of T2DM on the databases of 135
general practices in the East of England for further screening with ab fasting
elevated HbA1c [non -diabetic hyperglycaemia; NDH] are randomised into three
arm receiving the same intervention with enhanced support from people with T2DM
trained as diabetes prevention mentors [DPM]. The primary end point is cumulative
transition rates to T2DM between the two intervention groups, and between each
intervention group and the control group at 46 months. Participants with screen
detected T2DM are randomized into an equivalent prospective controlled trial with
the same intervention and control arms with glycaemic control [HbA1c] at
46 months as the primary end point. Participants with NDH and a normal fasting
intervention trial with follow up for 40 months. The intervention comprises six
education sessions for the first 12 weeks and then up to 15 maintenance sessions
until intervention end, all delivered in groups, with additional support from a
DISCUSSION: The NDPS programme reports in 2018 and will provide trial outcome
and that takes into account the realities of normal clinical practice.
DOI: 10.1186/s12889-016-3929-5
PMCID: PMC5217324
PMID: 28056894 [Indexed for MEDLINE]
breakfast combined with exercise after dinner and dividing meals for the
cohort study.
Author information:
BACKGROUND: This study aimed to examine the switch from glargine+once daily
combined with exercise and in patients with type 2 diabetes mellitus (T2DM) with
METHODS: Consecutive patients with poorly controlled T2DM (n = 182) were switched
combination with exercise after dinner and dividing meals in two (same final
calories intake). The insulin doses were adjusted according to blood glucose
levels within 4 weeks after the switch and maintained for 12 weeks. Fasting blood
body mass index (BMI), daily insulin dose, and hypoglycemia events were assessed.
RESULTS: Sixteen weeks after the switch, 2 h PG levels and HbA1c levels (from 8.5
to 7.4%, P = 0.001) were improved. The proportions of patients reaching the HbA1c
targets of 7.5% were improved (from 22.5 to 58.7%, P = 0.001). Among the 182
patients, 24 (13.2%) divided one meal into two meals, and 23 (12.6%) divided two
meals into four meals. Among all patients, 8.5% had to reuse insulin aspart
before dinner after the study. One patient with diarrhea and poor appetite
events/patient-year. The daily insulin Aspart 30 dose was higher than the
CONCLUSIONS: For patients with poorly controlled T2DM under the 1 + 1 regimen,
DOI: 10.1186/s12902-018-0297-4
PMCID: PMC6167858
PMID: 30285711
Chen LH(1), Chien YW(2)(3)(4), Chang ML(5), Hou CC(6), Chan CH(7), Tang HW(8),
Huang HY(9)(10).
Author information:
Taiwanese green propolis ethanol extract (TGPE) is produced only in Taiwan and
has a different composition from other types of propolis. TGPE is known for its
and mechanisms of TGPE in the modulation of diabetes are unclear. In this study,
revealed that TGPE delayed the development and progression of T2DM and reduced
reactive oxygen species ROS in the rats. Moreover, there were higher levels of
group. Unlike Brazilian propolis, TGPE promoted hepatic genes PPAR-α and
CYP7A1, which were related to lipid catabolism and removal. TGPE may thus delay
PMCID: PMC5946288
Author information:
Benoit.Lamarche@fsaa.ulaval.ca.
intra-abdominal obesity and ectopic lipid deposition in the liver, and also
exacerbates cardiometabolic risk. Similar to the prevalence of obesity and T2D,
SSBs is skyrocketing in many parts of the world, yet with marked heterogeneity
and obesity, T2D, and CVD are rather consistent in epidemiological studies, it
has also been shown that SSB overconsumption is part of an overall poor dietary
pattern and is particularly prevalent among subgroups of the population with low
poor dietary patterns and aiming at improving global dietary quality are likely
to have much more impact in addressing the unprecedented public health challenges
DOI: 10.3390/nu9060600
PMCID: PMC5490579
eCollection 2017.
Technical efficiency of rural primary health care system for diabetes treatment
A(1).
Author information:
(1)Department of Epidemiology, School of Public Health, Iran University of
Iran.
BACKGROUND: Our aim was to explore the technical efficiency (TE) of the Iranian
rural primary healthcare (PHC) system for diabetes treatment coverage rate using
the stochastic frontier analysis (SFA) as well as to examine the strength and
function of health system inputs (Behvarz worker density, physician density, and
rural health center density) and non-health system inputs (urbanization rate,
median age of population, and wealth index) as a set of covariates. Data about
the rate of self-reported diabetes treatment coverage was obtained from the
were collected from the health census database and data about non-health system
inputs were collected from the census data and household survey.
RESULTS: In 2008, rate of diabetes treatment coverage was 67% (95% CI: 63%-71%)
nationally, and at the provincial level it varied from 44% to 81%. The TE score
at the national level was 87.84%, with considerable variation across provinces
(from 59.65% to 98.28%).Among health system and non-health system inputs, only
CONCLUSION: Our findings show that although the rural PHC system can considered
DOI: 10.1186/s40200-017-0312-8
PMCID: PMC5556340
PMID: 28815169
eCollection 2017.
Intapad S(1)(2), Dasinger JH(2), Fahling JM(2), Backstrom MA(2), Alexander BT(2).
Author information:
risk for chronic disease including impaired glucose metabolism in low birth
weight infants. Using a rat model of low birth weight, we previously reported
Thus, the aim of this paper was to determine whether mIUGR develop impaired
glucose metabolism, and whether a decrease in elevated testosterone levels plays
control. Fasting blood glucose was significantly higher and glucose tolerance was
compared with 6 months of age. Castration did not additionally impair fasting
improved glucose tolerance in mIUGR. Thus, our findings suggest that the
DOI: 10.1371/journal.pone.0187843
PMCID: PMC5690651
252. Endocr Connect. 2018 Jan;7(1):220-231. doi: 10.1530/EC-17-0253. Epub 2017 Dec 12.
Testosterone level and risk of type 2 diabetes in men: a systematic review and
meta-analysis.
Author information:
China.
impaired sex steroid status. Some studies also investigated the association of
meta-analysis.
METHODS: PubMed, EMBASE and Web of Science were searched for eligible cohort or
used to calculate the pooled relative risk (RR) of type 2 diabetes associated
were included. Meta-analysis showed that higher total testosterone level could
0.50-0.84; P = 0.001), and higher free testosterone level could also decrease the
excluding two studies that did not calculate RRs by quartiles of testosterone
levels, both higher total testosterone and free testosterone levels could
decrease the risk of type 2 diabetes in men, and the pooled RRs were 0.62 (95% CI
men.
DOI: 10.1530/EC-17-0253
PMCID: PMC5793809
PMID: 29233816
Wu YT(1)(2), Song L(2)(3), Liu XX(4), Gao JS(2), Zheng XM(2), Ruan CY(2), Zhao
Author information:
China.
China.
China. biochemgao@163.com.
exposure to systolic (CumSBP) and of diastolic blood pressure (CumDBP) with onset
socioeconomic and lifestyle parameters and as compared with the first group, the
5 mmHg/year was associated with a hazard ratio of incident diabetes of 1.04 (95%
PMCID: PMC5414153
eCollection 2017.
Transgene and islet cell delivery systems using nano-sized carriers for the
Author information:
Japan.
Gene therapy that targets the pancreas and intestines with delivery systems using
nano-sized carriers such as viral and non-viral vectors could improve the control
mellitus. This review focuses on transgenes and islet cell delivery systems using
DOI: 10.1080/20022727.2017.1341758
PMCID: PMC6167029
PMID: 30410709
255. Diabetes Educ. 2017 Jun;43(3):311-323. doi: 10.1177/0145721717701579. Epub 2017
Apr 21.
Bergen PM(1), Kruger DF(2), Taylor AD(3), Eid WE(1)(4)(5)(6), Bhan A(2), Jackson
JA(3).
Author information:
Bergen, Dr Eid).
Jackson).
educator/expert prescriber team for the use of human regular U-500 insulin
its initiation and titration, by utilizing dosing charts and teaching materials
recommendations and teaching materials for the optimal use and management of
U-500R in clinical practice are provided based on the efficacy and safety results
of and lessons learned from the U-500R clinical trial by Hood et al, current
standards of practice, and the authors' clinical expertise. This trial was the
to the initiation and titration dosing algorithms used in this trial to simplify
dosing strategies for the clinical setting and align with current glycemic
expertise, resources, and patient interactions of the diabetes educator who can
treated with U-500R receive the timely and comprehensive care required to safely
DOI: 10.1177/0145721717701579
PMCID: PMC5439542
Study.
Author information:
planning and prevention. To better understand incidence trends over time requires
separation of age and cohort effects, and few prior studies have used this
approach.
dementia incidence in persons enrolled in the Einstein Aging Study from October
sample of 1348 participants from Bronx County, New York, who were 70 years or
older without dementia at enrollment and at least one annual follow-up was
age, sex, educational level, race, and birth cohort, with profile likelihood used
Results: Among 1348 individuals (mean [SD] baseline age, 78.5 [5.4] years; 830
[61.6%] female; 915 [67.9%] non-Hispanic white), 150 incident dementia cases
developed during 5932 person-years (mean [SD] follow-up, 4.4 [3.4] years).
person-years was 5.09 in birth cohorts before 1920, 3.11 in the 1920 through 1924
birth cohorts, 1.73 in the 1925 through 1929 birth cohorts, and 0.23 in cohorts
dementia incidence among those born after July 1929 (95% CI, June 1929 to January
1930). The relative rate for birth cohorts before July 1929 vs after was 0.13
Adjustment for these cardiovascular comorbidities did not explain the decreased
DOI: 10.1001/jamaneurol.2017.1964
PMCID: PMC5710583
Trends in obesity and diabetes across Africa from 1980 to 2014: an analysis of
Engle-Stone R, Erasmus RT, Fouad HM, Gareta D, Gureje O, Hendriks ME, Houti L,
Ibrahim MM, Kemper HCG, Killewo J, Kowlessur S, Kruger HS, Laamiri FZ, Laid Y,
Mohamed MK, Mondo CK, Monyeki KD, Mostafa A, Nankap M, Owusu-Dabo E, Rinke de Wit
TF, Saidi O, Schultsz C, Schutte AE, Senbanjo IO, Shaw JE, Smeeth L, Sobngwi E,
Ukoli FAM, Viswanathan B, Wade AN, Danaei G, Stevens GA, Riley LM, Ezzati M,
Mbanya JCN.
Background: The 2016 Dar Es Salaam Call to Action on Diabetes and Other
and action plans based on available data and information from countries of
Methods: We pooled data from African and worldwide population-based studies which
aged ≥ 18 years. A Bayesian hierarchical model was used to estimate trends by sex
for 200 countries and territories including 53 countries across five African
regions (central, eastern, northern, southern and western), in mean BMI and
Results: African data came from 245 population-based surveys (1.2 million
prevalence estimates. Countries with the highest number of data sources for BMI
were South Africa (n = 17), Nigeria (n = 15) and Egypt (n = 13); and for diabetes
estimates, Tanzania (n = 8), Tunisia (n = 7), and Cameroon, Egypt and South
Africa (all n = 6). The age-standardized mean BMI increased from 21.0 kg/m2 (95%
and from 4.1% (2.0-7.5) to 8.9% (6.9-11.2) in women. Estimates in northern and
southern regions were mostly higher than the global average; those in central,
eastern and western regions were lower than global averages. A positive
association (correlation coefficient ≃ 0.9) was observed between mean BMI and
Conclusions: These estimates, based on limited data sources, confirm the rapidly
African countries' efforts to prevent and control diabetes and obesity should
DOI: 10.1093/ije/dyx078
PMCID: PMC5837192
Author information:
Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600/414, Porto Alegre, RS
Tubarão, Brazil.
Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600/414, Porto Alegre, RS
90035-003 Brazil.
ranked 4th in the world in terms of the absolute number of persons with diabetes.
Our aim was to analyze the trend in self-reported diabetes prevalence between
METHODS: We used data from the national telephone survey-VIGITEL. Over 40,000
state capitals and the Federal District were interviewed per year in each
location. Estimates were weighted to represent the surveyed population. We
RESULTS: From 2006 to 2014, the overall prevalence increased from 5.5 to 8.0 %, a
net rise of 0.26 %/year (P = 0.001). After adjustment for sex, age, schooling and
BMI categories, the trend decreased only slightly to 0.25 %/year. Relatively
greater adjusted increases were present in men (0.28 %/year), in those ≥65 years
(0.52 %/year), with ≤8 years of schooling (0.33 %/year) and in those overweight
(0.24 %/year). The most consistent upward trends were observed among men
0-8 years (R2 = 0.81), those > 65 years (R2 = 0.79) and those who were overweight
(R2 = 0.75). There was no significant trend in diabetes prevalence for the obese.
those with greater age, less schooling, in women, and in those with obesity.
Being obese was associated with having more than twice the prevalence of diabetes
of those normal/underweight.
between 2006 and 2014, especially among those 65 years or older, even after
taking into account the sociodemographic and nutritional changes during the
the health system, representing >300,000 newly diagnosed cases of diabetes yearly
DOI: 10.1186/s13098-016-0185-x
PMCID: PMC5064973
PMID: 27757172
Bilger M(1), Shah M(2), Tan NC(2), Howard KL(3), Xu HY(2), Lamoureux EL(4),
Finkelstein EA(3)(5).
Author information:
(1)Health Services and Systems Research, Duke-NUS Medical School, 8 College Road,
(3)Health Services and Systems Research, Duke-NUS Medical School, 8 College Road,
Singapore.
BACKGROUND: Many people with diabetes have suboptimal glycaemic control due to
suggests that the lack of adherence results from the disconnect between the
timing of when costs and benefits accrue. One strategy to address this
reward. Whereas there is evidence that rewards can improve treatment adherence
whether adding financial incentives to usual care can improve HbA1c levels among
people with diabetes and whether the financial incentives work better when
superiority trial with three parallel arms. A total of 240 patients with
block-randomised (blocking factor: current vs. new glucometer users) into three
arms, namely (1) usual care (UC) only, (2) UC with process incentive and (3) UC
with outcome incentive, in a 2:3:3 ratio. Masking the arm allocation will be
precluded by the behavioural nature of the intervention but blocking size will
study team. Secondary outcomes (at month 6) include the number of blood glucose
testing days, glucose readings within the normal range (between 4 to 7 mmol/L),
DISCUSSION: This study will provide evidence on whether financial incentives can
process to outcome incentives, this study will inform the design of future
22 August 2014.
DOI: 10.1186/s13063-017-2288-6
PMCID: PMC5693491
260. Diabetes Metab Syndr Obes. 2017 Aug 29;10:363-374. doi: 10.2147/DMSO.S145152.
eCollection 2017.
study.
Le NTD(1), Dinh Pham L(1), Quang Vo T(1).
Author information:
health care expenditures for diabetes tripled between 2003 and 2013 because of
expenditures per patient. This study aims to provide accurate and timely
Vietnam.
approach from the societal perspective of T2DM with 392 selected diabetic
patients who received treatment from a public hospital in Ho Chi Minh City,
RESULTS: In this study, the annual cost per patient estimate was US $246.10 (95%
CI 228.3, 267.2) for 392 patients, which accounted for about 12% (95% CI 11, 13)
of the gross domestic product per capita in 2017. That includes US $127.30, US
$34.40 and US $84.40 for direct medical costs, direct nonmedical expenditures,
and indirect costs, respectively. The cost of pharmaceuticals accounted for the
bulk of total expenditures in our study (27.5% of total costs and 53.2% of direct
medical costs). A bootstrap analysis showed that female patients had a higher
cost of treatment than men at US $48.90 (95% CI 3.1, 95.0); those who received
insulin and oral antidiabetics (OAD) also had a statistically significant higher
690.6). The Gradient Boosting Regression (Ensemble method) and Lasso Regression
(Generalized Linear Models) were determined to be the best models to predict the
cost of T2DM (R2=65.3, mean square error [MSE]=0.94; and R2=64.75, MSE=0.96,
respectively).
CONCLUSION: The findings of this study serve as a reference for policy decision
DOI: 10.2147/DMSO.S145152
PMCID: PMC5587014
PMID: 28919795
261. BMC Complement Altern Med. 2017 Feb 16;17(1):114. doi: 10.1186/s12906-017-1627-1.
Yimam M(1), Jiao P(2), Hong M(2), Brownell L(2), Lee YC(3), Hyun EJ(3), Kim
Author information:
(1)Unigen, Inc., 3005 1st Avenue, Seattle, WA, 98121, USA. myimam@unigen.net.
Korea.
BACKGROUND: The prevalence of obesity is surging in an alarming rate all over the
lifestyle modification. However, for most, besides being too expensive, their
long term usages are hindered by their severe adverse effects. Here we describe
the effect of UP601, a standardized blend of extracts from Morus alba, Yerba mate
and Magnolia officinalis, in modulating a number of obesity-related phenotypic
model of obesity.
vitro. Effects of UP601 on body weight and metabolic markers were evaluated. It
was administered at oral doses of 300 mg/kg, 450 mg/kg and 600 mg/kg for 7 weeks.
Orlistat (40 mg/kg/day) was used as a positive control. Body compositions of mice
were assessed using dual energy X-ray absorptiometry (DEXA). Serum biomarkers
were measured for liver function and lipid profiling. Relative organ weights were
25.6% compared to the HFF group at week-7) were observed for mice treated with
UP601 at 300, 450 and 600 mg/kg, respectively. Reductions of 9.1, 16.9, and 18.6%
in total cholesterol; 45.0, 55.0, 63.6% in triglyceride; 34.8, 37.1 and 41.6% in
LDL; 3.2, 21.6 (P = 0.03) and 33.7% (P = 0.005) in serum glucose were observed
for UP601 at 300, 450 and 600 mg/kg, respectively. Body fat distribution was
found reduced by 31.6 and 17.2% for the 450 mg/kg UP601 and orlistat,
fat deposit was observed for UP601 in relative organ weight. Statistically
significant improvements in NASH scores were observed for mice treated with
UP601.
mate and Magnolia officinalis could potentially be used for achieving healthy
DOI: 10.1186/s12906-017-1627-1
PMCID: PMC5314713
factors among 25-74 years old citizens in Yangon Region, Myanmar: a cross
sectional study.
Htet AS(1)(2), Bjertness MB(3), Sherpa LY(3), Kjøllesdal MK(3), Oo WM(4), Meyer
Author information:
aungsh@gmail.com.
BACKGROUND: Recent societal and political reforms in Myanmar may upturn the
are not thoroughly described in this country which has been relatively closed for
values and the prevalence of selected behavioral and metabolic risk factors for
diseases (CHD).
METHODS: Two cross-sectional studies were conducted in urban and rural areas of
Yangon Region in 2013 and 2014 respectively, using the WHO STEPwise approach to
higher in the rural than urban areas for all included factors and significantly
higher for alcohol drinking (19.9% vs. 13.9%; p = 0.040) and low fruit &
vegetable consumption (96.7% vs. 85.1%; p = 0.001). For the metabolic risk
estimates in urban than rural areas, significantly for overweight and obesity
combined (40.9% vs. 31.2%; p = 0.023), obesity (12.3% vs.7.7%; p = 0.019) and
higher in urban than rural areas among males, 61.8% vs. 40.4%; p = 0.002 and
metabolic parameters showed higher values in urban than rural areas for both male
and female. Based on WHO age-standardized Framingham risk scores, 33.0% (95%
dwellers had a moderate to high risk of developing CHD in the next 10 years.
risk of CHD were more common among urban residents whereas behavioral risk
factors levels were higher in among the rural people of Yangon Region. The high
prevalences of NCD risk factors in both urban and rural areas call for preventive
DOI: 10.1186/s12889-016-3882-3
PMCID: PMC5139102
Users, Uses, and Effects of Social Media in Dietetic Practice: Scoping Review of
Author information:
(#)Contributed equally
OBJECTIVE: The objective of this study was to map and summarize the evidence
about the users, uses, and effects of social media in dietetic practice to
identify gaps in the literature and inform future research by using a scoping
review methodology.
METHODS: Stages for conducting the scoping review included the following: (1)
eligible studies; (4) charting the data; and (5) collating, summarizing, and
reporting results for dissemination. Finally, knowledge users (RDs working for
descriptive studies, 2 were content analysis studies, and 7 were expert opinion
papers in dietetic practice. Discussion forums were the most frequent social
media platform evaluated (n=19), followed by blogs (n=13) and social networking
sites (n=10). Most studies targeted overweight and obese or healthy users, with
adult populations being most studied. Social media platforms were used to deliver
media, we identified positive, neutral, and mixed effects of social media for
outcomes related to users' health behaviors and status (eg, dietary intakes and
body weight), participation rates, and professional knowledge. Factors associated
with the characteristics of the specific social media, such as ease of use, a
design for quick access to desired information, and concurrent reminders of use,
were perceived as the main facilitators to the use of social media in dietetic
support from fellow users. Barriers to social media use were mostly related to
it is growing fast. So far, this field of research has targeted few social media
weight management among overweight or obese adults. Trials isolating the effects
and mechanisms of action of specific social media platforms are needed to draw
practice. Future studies should address barriers and facilitators related to the
use of social media written by RDs and should explore how to make these tools
useful for RDs to reach health consumers to improve health through diet.
DOI: 10.2196/jmir.9230
PMCID: PMC5840482
PMID: 29463487
264. Diabetes Care. 2018 Jul;41(7):1438-1447. doi: 10.2337/dc18-0181. Epub 2018 Apr
24.
KJ(3), Wu WY(3).
Author information:
York, NY.
(3)New York City Department of Health and Mental Hygiene, New York, NY.
(5)Wagner Graduate School of Public Service, New York University, New York, NY.
outcomes, but finding these areas can be difficult. Our objective was to use
RESEARCH DESIGN AND METHODS: Census tracts in New York City (NYC) were
diabetes having poor glycemic control, based on A1C >9.0% (75 mmol/mol). Hot spot
analyses were then performed, using the Getis-Ord Gi* statistic for all measures.
values, and accuracy of using the indirect measures to identify hot spots of poor
RESULTS: Using A1C Registry data, we identified hot spots in 42.8% of 2,085 NYC
89.6%, and 89.5% accuracy for identifying the same hot spots of poor glycemic
control found using A1C Registry data. No other indirect measure tested had
accuracy >80% except for the proportion of minority residents, which had 86.2%
accuracy.
diabetes.
DOI: 10.2337/dc18-0181
265. Dement Geriatr Cogn Dis Extra. 2016 Dec 5;6(3):541-548. doi: 10.1159/000450784.
Diabetes.
Author information:
(1)Glan Clwyd Hospital, Betsi Cadwaladr University Health Board, NHS Wales,
Bodelwyddan, UK.
(2)Glan Clwyd Hospital, Betsi Cadwaladr University Health Board, NHS Wales,
Examination (M-ACE) in a cohort of older adults with chronic kidney disease (CKD)
and diabetes.
METHOD: The M-ACE was administered to 112 CKD and diabetes patients attending a
nephrology clinic. Cognitive impairment was based upon patient, informant, and
cognitive impairment (MCI) and the Diagnostic and Statistical Manual of Mental
Disorders, fifth edition for dementia. The M-ACE was also compared to the
RESULTS: Upon assessment, 52 patients had normal cognitive function, 33 had MCI,
and 27 had dementia. The area under the receiver operating curve for the M-ACE
was 0.96 (95% CI 0.95-1.00). The sensitivity and specificity for a dementia
diagnosis were 0.96 and 0.84 at the cut point <25 and 0.70 and 1.00 at the cut
point <21. Mean M-ACE scores differed significantly between normal, demented, and
MCI groups (p < 0.001), and compared to the MMSE, the M-ACE did not suffer from
ceiling effects.
CONCLUSION: The M-ACE is an easily administered test with good sensitivity and
DOI: 10.1159/000450784
PMCID: PMC5216187
PMID: 28101100
Tunisian population.
Author information:
Tunisia.
find out the optimal cut-off point for screening of Type 2 diabetes (T2D) and
prediabetes.
METHODS: 225 adults 18-75 years and a subgroup of 138 adults (18-54 years), with
undiagnosed T2D from the region of Cap-Bon, Tunisia were included in the present
study. The DIABSCORE was calculated based on: age, waist/height ratio, family
curves and areas under curve (AUC) were obtained. The T2D and prediabetes
prevalences odds ratios (OR) between patients exposed and not exposed to
RESULTS: For screening of T2D the best value was DIABSCORE = 90 with a highest
sensitivity (Se), negative predictive value (NPV) and lower negative likelihood
ratio in participants aged 18-75 yr (Se = 97%; NPV = 97%) when compared to
participants aged 18-54 yr (Se = 95%; NPV = 97%); for prediabetes, the best Se
and NPV were for DIABSCORE = 80 in both age groups, but it showed a disbalanced
sensitivity-specificity. The ROC curves for T2D showed a similar AUC in both age
ranges (AUC = 0.62 and AUC = 0.61 respectively). The ROC curves for prediabetes
showed a highest AUC in those aged 18-54 years than the older ones (AUC = 0.62
and AUC = 0.57, respectively). The prevalences OR of T2D for DIABSCORE≥90 was
higher than for DIABSCORE≥80 in both age ranges. Nevertheless, the prevalences OR
of prediabetes for DIABSCORE≥90 was half of the detected for DIABSCORE≥80 in both
age ranges.
DOI: 10.1371/journal.pone.0200718
PMCID: PMC6093602
PMID: 30110336
interests exist.
Zack RM(1), Irema K(2), Kazonda P(2), Leyna GH(2), Liu E(3), Gilbert S(3),
Lukmanji Z(4), Spiegelman D(1), Fawzi W(1), Njelekela M(5), Killewo J(2), Danaei
G(1).
Author information:
(1)1Department of Epidemiology,Harvard T.H. Chan School of Public Health,Kresge
Health,Boston,MA,USA.
OBJECTIVE: FFQ are often used to estimate food and nutrient intakes to rank
diet recalls.
es Salaam, Tanzania.
SUBJECTS: We surveyed 317 adults aged 40 years or older from the general public.
ranged from -0·03 for riboflavin to 0·41 for percentage of energy from
ranged from 0·00 for root vegetables to 0·51 for alcohol, with a median of 0·35.
Relative to the average of the two 24 h diet recalls, the FFQ overestimated
energy intake and intakes of all nutrients and food groups, other than tea, with
ratios among nutrients ranging from 1·34 for SFA to 7·08 for vitamin A; and among
food groups from 0·92 for tea to 9·00 for fruit. The percentage of participants
classified into the same nutrient intake quartile ranged from 23 % for SFA to 32
% for both niacin and pantothenic acid, with a median of 28 %.
DOI: 10.1017/S1368980018000848
PMID: 29656731
Validity of Indian Diabetes Risk Score and its association with body mass index
Lucknow.
Khan MM(1), Sonkar GK(2), Alam R(1), Mehrotra S(3), Khan MS(4), Kumar A(1),
Sonkar SK(5).
Author information:
Pradesh, India.
Objectives: The present study aimed to assess the validity of Indian Diabetes
Risk Score (IDRS) and its association with body mass index (BMI) and glycosylated
enrolled from Lucknow and its adjoining areas. Totally, 405 subjects were
included in the study. We used diabetes risk factors (age, waist circumference,
physical activity, and family history of diabetes) for screening of diabetes and
abdominal obesity (AO) and BMI for screening of general obesity. HbA1c was used
for confirming the diabetes patients in this population. Statistical analysis was
applied to all data using SPSS software (version 20.0). P < 0.05 was considered
statistically significant.
Results: All 405 subjects were assessed for diabetic risk factors, BMI, and
glycated hemoglobin. Of these, 56.3% subjects were aged ≥50 years. 1° and 2° AO
was found in 47.9% and 40% subjects, respectively. About 27.1% subjects were
found to have sedentary lifestyle, and 72.6% were found to have no family history
of diabetes. According to IDRS, 272 subjects (67.2%) were found at high risk of
diabetes (score ≥60). Based on BMI calculation, 198 subjects were obese, of which
79.3% were found at high risk for diabetes. A significant association was found
between subjects with higher risk score and BMI (P < 0.001). Assessment of HbA1c
showed that 97 (23.9%) were prediabetic and 204 (50.4%) were diabetic, of which
63.9% and 77%, respectively was at high risk for diabetes as per IDRS. A
significant association was found between subjects with higher risk score and
Conclusion: Our study fully supports the validity of IDRS, as it can be used as a
combination with BMI value and HbA1c can be used for strict monitoring for
diabetes and obesity at primary health care centers to reduce the early
DOI: 10.4103/2249-4863.220010
PMCID: PMC5749088
PMID: 29302549
study.
Author information:
(1)Department of Nutrition Therapy, Dalin Tzu Chi Hospital, Buddhist Tzu Chi
Medical Foundation. No. 2, Min-Sheng Road, Dalin Town, Chiayi County, 622,
Taiwan.
(5)Department of Family Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi
Medical Foundation. No. 2, Min-Sheng Road, Dalin Town, Chiayi County, 622,
Taiwan. mingnan.lin@gmail.com.
Hualien, Taiwan. No.701, Sec. 3, Chung Yang Road, Hualien, 970, Taiwan.
mingnan.lin@gmail.com.
Taiwan. No. 707, Sec. 3, Chung Yang Road, Hualien, 970, Taiwan.
Hualien, Taiwan. No.701, Sec. 3, Chung Yang Road, Hualien, 970, Taiwan.
population.
a median of 5 years, with 183 incident diabetes cases confirmed. Diet was
Stratified Cox Proportional Hazards Regression was used to assess the effect of
RESULTS: Consistent vegetarian diet was associated with 35% lower hazards (HR:
0.65, 95% CI: 0.46, 0.92), while converting from a nonvegetarian to a vegetarian
pattern was associated with 53% lower hazards (HR: 0.47, 95% CI: 0.30, 0.71) for
CONCLUSION: Vegetarian diet and converting to vegetarian diet may protect against
DOI: 10.1038/s41387-018-0022-4
PMCID: PMC5856738
PMID: 29549240
We Know More Than We Can Tell About Diabetes and Vascular Disease: The 2016 Edwin
Author information:
The Edwin Bierman Award Lecture is presented in honor of the memory of Edwin L.
Bierman, MD, an exemplary scientist, mentor, and leader in the field of diabetes,
risk factors in diabetes. Clay F. Semenkovich, MD, the Irene E. and Michael M.
Karl Professor and Chief of the Division of Endocrinology, Metabolism and Lipid
Research at Washington University School of Medicine in St. Louis, St. Louis, MO,
Scientific Sessions, 10-14 June 2016, in New Orleans, LA. He presented the Edwin
Bierman Award Lecture, "We Know More Than We Can Tell About Diabetes and Vascular
metabolism, a notion strongly supported by the work of Edwin Bierman, for whom
studies of this enzyme suggest that endogenously produced lipids are channeled to
specific intracellular sites to affect physiology. These findings raise the
DOI: 10.2337/db17-0093
PMCID: PMC5482089
Murray E(1), Sweeting M(2), Dack C(3), Pal K(1), Modrow K(1), Hudda M(4), Li
J(5), Ross J(1), Alkhaldi G(1), Barnard M(6), Farmer A(7), Michie S(8), Yardley
L(7)(9), May C(10), Parrott S(5), Stevenson F(1), Knox M(1), Patterson D(6).
Author information:
London, UK.
programme for people with type 2 diabetes in improving glycaemic control and
INTERVENTION AND COMPARATOR: Usual care plus either Healthy Living for People
information only.
OUTCOMES AND DATA COLLECTION: Joint primary outcomes were glycated haemoglobin
linear mixed effects model, adjusted for baseline data with multiple imputation
of missing values.
RESULTS: Of the 374 participants randomised between September 2013 and December
2014, 185 were allocated to the intervention and 189 to the control. Final (12
month) follow-up data for HbA1c were available for 318 (85%) and for PAID 337
(90%) of participants. Of these, 291 (78%) and 321 (86%) responses were recorded
group had lower HbA1c than those in the control (mean difference -0.24%; 95% CI
-0.44 to -0.049; p=0.014). There was no significant overall difference between
groups in the mean PAID score (p=0.21), but prespecified subgroup analysis of
participants who had been more recently diagnosed with diabetes showed a
reported harms.
© Article author(s) (or their employer(s) unless otherwise stated in the text of
the article) 2017. All rights reserved. No commercial use is permitted unless
DOI: 10.1136/bmjopen-2017-016009
PMCID: PMC5623569
Weight cycling and the subsequent onset of type 2 diabetes mellitus: 10-year
Yokomichi H(1), Ohde S(2), Takahashi O(2), Mochizuki M(3), Takahashi A(1), Yoda
Author information:
Japan.
OBJECTIVE: To investigate how weight cycling (gaining and losing weight) affects
PRIMARY OUTCOME MEASURES: ORs for diabetes in those with weight loss, weight
loss-gain, stable weight, weight gain-loss and weight gain over 10 years. Weight
gain and loss were defined as a change of more than ±4% from baseline weight.
RESULTS: In the urban region, the ORs relative to the stable group for the
loss-gain and gain-loss groups were 0.63 (95% CI 0.45 to 0.89) and 0.51 (95% CI
0.32 to 0.82) for men and 0.72 (95% CI 0.39 to 1.34) and 1.05 (95% CI 0.57 to
1.95) for women. In the rural region, they were 1.58 (95% CI 0.78 to 3.17) and
0.44 (95% CI 0.15 to 1.29) in men and 0.41 (95% CI 0.12 to 1.44) and 0.77 (95% CI
0.28 to 2.14) in women. The ORs for an increase in weight between 5 and 10 kg
from the age of 20 years were 1.54 (95% CI 1.03 to 2.30) in men and 0.96 (95% CI
in the risk of diabetes for men from urban regions. The associations were unclear
for women from urban regions and both men and women from rural regions. These
© Article author(s) (or their employer(s) unless otherwise stated in the text of
the article) 2017. All rights reserved. No commercial use is permitted unless
otherwise expressly granted.
DOI: 10.1136/bmjopen-2016-014684
PMCID: PMC5729995
eCollection 2018.
Chérrez-Ojeda I(1)(2), Vanegas E(1)(2), Calero E(2), Plaza K(2), Cano JA(1)(2),
Author information:
mellitus. A chi-square test for association and adjusted regression analyses were
performed.
Results: 248 patients were enrolled, with a mean sample age of 57.7 years. SMS
was the most used ICT (66.0%). The Internet was used by 45.2% of patients to
obtain information about diabetes. SMS and email were rated as the most useful
ICTs for receiving information (64.5% and 28.1%, resp.) and asking physicians
about diabetes (63.8% and 26.1%, resp.). Patients were also interested in
aged 55 years or younger, those with superior degree level, and those with long
diabetes history preferred email for receiving information and asking physicians
about diabetes compared to those above 55 years, those with low education level,
patients.
DOI: 10.1155/2018/3427389
PMCID: PMC5832117
PMID: 29666639
White rice intake and incidence of type-2 diabetes: analysis of two prospective
Golozar A(1)(2), Khalili D(3), Etemadi A(1)(4), Poustchi H(1), Fazeltabar A(1),
Hosseini F(5), Kamangar F(6), Khoshnia M(7), Islami F(8), Hadaegh F(3), Brennan
P(9), Boffetta P(10), Abnet CC(4), Dawsey SM(4), Azizi F(11), Malekzadeh R(1),
Danaei G(12)(13)(14).
Author information:
17413, Iran.
Mount Sinai School of Medicine, New York, 10029, New York, USA.
(14)SAPHIR, the Scientific Association for Public Health in Iran , Boston, 02132,
USA. gdanaei@hsph.harvard.edu.
BACKGROUND: Refined grains and white rice have been associated with elevated risk
cohort studies from Iran, where white rice is one of the main staple.
METHODS: We used follow-up data from 9,182 participants from Golestan Cohort
Study (GCS, 2004-2007, conducted mainly in rural areas) and 2,173 from Tehran
Lipid and Glucose Study (TLGS, 2004-2006) who did not have T2DM and other chronic
Tehran. Daily white rice intake was significantly higher among residents of
Tehran compared to Golestan (median daily intake: 250 vs. 120 grams;
significant association between daily white rice intake and incident T2DM in GCS.
In TLGS, the adjusted OR (95% confidence interval (CI)) was 2.1 (1.1, 3.9)
comparing participants with daily white rice intake of >250 grams/day to those
with <250.
white rice intake among residents of Tehran and no association in Golestan. Our
implications especially for countries where white rice is a major staple and
investigate lack of an association between lower levels of white rice intake and
T2DM.
DOI: 10.1186/s12889-016-3999-4
PMCID: PMC5282785
eCollection 2017.
The WHO global reference list of 100 core health indicators: the example of
Sierra Leone.
Kaiser R(1), Johnson N(1), Jalloh MF(2), Dafae F(3), Redd JT(2), Hersey S(1),
Jambai A(3).
Author information:
(1)Centers for Disease Control and Prevention (CDC) Country Office, Freetown,
Sierra Leone.
(2)Division of Global Health Protection, Center for Global Health, Centers for
The global reference list of 100 core health indicators is a standard set of
health indicators in the public domain and in-country for Sierra Leone, the
with open access in the literature and compared them with cumulative annual
Sierra Leone from Internet sources and 2 (maternal mortality and malaria
2015 and the most recent national bulletin. We were able to obtain the majority
of core indicators for Sierra Leone. Some indicators were similar but not
identical, uncertainty intervals were limited and estimates differed for the same
considered.
DOI: 10.11604/pamj.2017.27.246.11647
PMCID: PMC5622828
10.1016/S2213-8587(18)30150-5.
Pearson-Stuttard J(1), Zhou B(2), Kontis V(2), Bentham J(3), Gunter MJ(4), Ezzati
M(5).
Author information:
(1)School of Public Health, MRC-PHE Centre for Environment and Health, Imperial
j.pearson-stuttard@imperial.ac.uk.
(2)School of Public Health, MRC-PHE Centre for Environment and Health, Imperial
Imperial College London, London, UK; School of Public Health, MRC-PHE Centre for
Canterbury, UK.
(5)School of Public Health, MRC-PHE Centre for Environment and Health, Imperial
of Public Health, Imperial College London, London, UK; WHO Collaborating Centre
BACKGROUND: Diabetes and high body-mass index (BMI) are associated with increased
sex for 175 countries in 2012. We defined high BMI as a BMI greater than or equal
BMI and incidence of cancer, combined with relative risks from published
high BMI. We then used GLOBOCAN cancer incidence data to estimate the number of
cancer cases attributable to the two risk factors. We also estimated the number
diabetes and high BMI from 1980 to 2002. All analyses were done at individual
attributable to the combined effects of diabetes and high BMI as independent risk
factors, corresponding to 804 100 new cases. 187 600 (24·5%) of 766 000 cases of
liver cancer and 121 700 (38·4%) of 317 000 cases of endometrial cancer were
diabetes and high BMI combined. Individually, high BMI (544 300 cases) was
responsible for almost twice as many cancer cases as diabetes (293 300 cases).
and high BMI. As the prevalence of these cancer risk factors increases, clinical
and public health efforts should focus on identifying optimal preventive and
Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access
article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights
reserved.
DOI: 10.1016/S2213-8587(18)30150-5
PMCID: PMC5982644
PMID: 29803268
M(5).
Author information:
(1)School of Public Health, MRC-PHE Centre for Environment and Health, Imperial
j.pearson-stuttard@imperial.ac.uk.
(2)School of Public Health, MRC-PHE Centre for Environment and Health, Imperial
(3)School of Public Health, MRC-PHE Centre for Environment and Health, Imperial
(5)School of Public Health, MRC-PHE Centre for Environment and Health, Imperial
of Public Health, Imperial College London, London, UK; WHO Collaborating Centre
Retraction in
Comment in
sex for 175 countries in 2012. We defined high BMI as a BMI greater than or equal
BMI and incidence of cancer, combined with relative risks from published
high BMI. We then used GLOBOCAN cancer incidence data to estimate the number of
cancer cases attributable to the two risk factors. We also estimated the number
diabetes and high BMI from 1980 to 2002. All analyses were done at individual
attributable to the combined effects of diabetes and high BMI as independent risk
liver cancer and 121 700 (38·4%) of 317 000 cases of endometrial cancer were
diabetes and high BMI combined. Individually, high BMI (544 300 cases) was
responsible for twice as many cancer cases as diabetes (280 100 cases). 26·1% of
and high BMI. As the prevalence of these cancer risk factors increases, clinical
and public health efforts should focus on identifying optimal preventive and
Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access
article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights
reserved.
DOI: 10.1016/S2213-8587(17)30366-2
PMCID: PMC5805864
PMID: 29195904
Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479
Y, Stevens GA, Riley LM, Bovet P, Elliott P, Gu D, Ikeda N, Jackson RT, Joffres
M, Kengne AP, Laatikainen T, Lam TH, Laxmaiah A, Liu J, Miranda JJ, Mondo CK,
Woyatan R, Ali MM, Alkerwi A, Aly E, Amouyel P, Amuzu A, Andersen LB, Anderssen
Barbagallo CM, Barceló A, Barkat A, Barros AJD, Barros MV, Bata I, Batieha AM,
Capuano V, Cardoso VC, Carlsson AC, Carvalho MJ, Casanueva FF, Casas JP, Caserta
CA, Chamukuttan S, Chan AW, Chan Q, Chaturvedi HK, Chaturvedi N, Chen CJ, Chen F,
Chen H, Chen S, Chen Z, Cheng CY, Dekkaki IC, Chetrit A, Chiolero A, Chiou ST,
Castelnuovo AF, Dias-da-Costa JS, Diaz A, Dickerson TT, Do HTP, Dobson AJ,
Elliott P, Elosua R, Erasmus RT, Erem C, Eriksen L, de la Peña JE, Evans A, Faeh
LH, Forslund AS, Forsner M, Fortmann SP, Fouad HM, Francis DK, Franco MDC, Franco
OH, Frontera G, Fuchs FD, Fuchs SC, Fujita Y, Furusawa T, Gaciong Z, Gareta D,
Garnett SP, Gaspoz JM, Gasull M, Gates L, Gavrila D, Geleijnse JM, Ghasemian A,
Henriques A, Cadena LH, Herrala S, Heshmat R, Hihtaniemi IT, Ho SY, Ho SC, Hobbs
M, Hofman A, Dinc GH, Hormiga CM, Horta BL, Houti L, Howitt C, Htay TT, Htet AS,
Ibrahim MM, Ikram MA, Irazola VE, Islam M, Ivkovic V, Iwasaki M, Jackson RT,
Khader YS, Khalili D, Khang YH, Khaw KT, Kiechl S, Killewo J, Kim J, Klumbiene J,
Krokstad S, Kromhout D, Kruger HS, Kubinova R, Kuciene R, Kuh D, Kujala UM, Kula
Laugsand LE, Laxmaiah A, Bao KLN, Le TD, Leclercq C, Lee J, Lee J, Lehtimäki T,
Lekhraj R, León-Muñoz LM, Levitt NS, Li Y, Lilly CL, Lim WY, Lima-Costa MF, Lin
HH, Lin X, Linneberg A, Lissner L, Litwin M, Lorbeer R, Lotufo PA, Lozano JE,
Posso AJMD, McFarlane SR, McGarvey ST, McLachlan S, McLean RM, McNulty BA, Khir
Menon GR, Meshram II, Metspalu A, Mi J, Mikkel K, Miller JC, Miquel JF,
MFM, Møller NC, Molnár D, Momenan A, Mondo CK, Monyeki KDK, Moreira LB, Morejon
Naidu BM, Nakamura H, Námešná J, Nang EEK, Nangia VB, Narake S, Navarrete-Muñoz
EM, Ndiaye NC, Neal WA, Nenko I, Nervi F, Nguyen ND, Nguyen QN, Nieto-Martínez
RE, Niiranen TJ, Ning G, Ninomiya T, Nishtar S, Noale M, Noboa OA, Noorbala AA,
MA, Onat A, Ordunez P, Osmond C, Ostojic SM, Otero JA, Overvad K, Owusu-Dabo E,
Peeters PH, Peixoto SV, Pelletier C, Peltonen M, Pereira AC, Pérez RM, Peters A,
Pradeepa R, Prashant M, Price JF, Puiu M, Punab M, Qasrawi RF, Qorbani M, Radic
Rampal S, Reina DAR, Rasmussen F, Redon J, Reganit PFM, Ribeiro R, Riboli E, Rigo
D, Santos IS, Dos Santos RN, Santos R, Saramies JL, Sardinha LB, Margolis GS,
Schultsz C, Schutte AE, Sen A, Senbanjo IO, Sepanlou SG, Sharma SK, Shaw JE,
Shibuya K, Shin DW, Shin Y, Siantar R, Sibai AM, Silva DAS, Simon M, Simons J,
Song Y, Sørensen TI, Jérome CS, Soumare A, Staessen JA, Starc G, Stathopoulou MG,
Sundström J, Sung YT, Suriyawongpaisal P, Sy RG, Tai ES, Tammesoo ML, Tamosiunas
Theobald H, Thijs L, Thuesen BH, Tjonneland A, Tolonen HK, Tolstrup JS, Topbas M,
Turley ML, Tynelius P, Tzourio C, Ueda P, Ugel E, Ulmer H, Uusitalo HMT, Valdivia
G, Valvi D, van der Schouw YT, Van Herck K, van Rossem L, van Valkengoed IG,
Wang MD, Wang Q, Wang YX, Wannamethee SG, Wareham N, Wederkopp N, Weerasekera D,
Whincup PH, Widhalm K, Widyahening IS, Wiecek A, Wijga AH, Wilks RJ, Willeit J,
Willeit P, Williams EA, Wilsgaard T, Wojtyniak B, Wong TY, Wong-McClure RA, Woo
Comment in
Comment on
systolic and mean diastolic blood pressure, and the prevalence of, and number of
people with, raised blood pressure, defined as systolic blood pressure of 140 mm
population-based studies that had measured blood pressure in adults aged 18 years
and older. We used a Bayesian hierarchical model to estimate trends from 1975 to
2015 in mean systolic and mean diastolic blood pressure, and the prevalence of
FINDINGS: We pooled 1479 studies that had measured the blood pressures of 19·1
million adults. Global age-standardised mean systolic blood pressure in 2015 was
and 20·1% (17·8-22·5) in women in 2015. Mean systolic and mean diastolic blood
Asia Pacific countries, moving these countries from having some of the highest
worldwide blood pressure in 1975 to the lowest in 2015. Mean blood pressure also
decreased in women in central and eastern Europe, Latin America and the
Caribbean, and, more recently, central Asia, Middle East, and north Africa, but
in east and southeast Asia, south Asia, Oceania, and sub-Saharan Africa. In 2015,
central and eastern Europe, sub-Saharan Africa, and south Asia had the highest
The number of adults with raised blood pressure increased from 594 million in
1975 to 1·13 billion in 2015, with the increase largely in low-income and
middle-income countries. The global increase in the number of adults with raised
blood pressure is a net effect of increase due to population growth and ageing,
INTERPRETATION: During the past four decades, the highest worldwide blood
in south Asia and sub-Saharan Africa due to opposite trends, while blood pressure
article under the CC BY license. Published by Elsevier Ltd.. All rights reserved.
DOI: 10.1016/S0140-6736(16)31919-5
PMCID: PMC5220163
Anderssen SA, Andrade DS, Ängquist LH, Anjana RM, Aounallah-Skhiri H, Araújo J,
Assunção MCF, Aung MS, Avdicová M, Azevedo A, Azizi F, Babu BV, Bahijri S, Baker
Barceló A, Barkat A, Barros AJ, Barros MV, Bata I, Batieha AM, Batista RL,
Batyrbek A, Baur LA, Beaglehole R, Romdhane HB, Benedics J, Benet M, Bennett JE,
M, Capuano V, Cardoso VC, Carlsson AC, Carvalho MJ, Casanueva FF, Casas JP,
Caserta CA, Chamukuttan S, Chan AW, Chan Q, Chaturvedi HK, Chaturvedi N, Chen CJ,
Djalalinia S, Do HT, Dobson AJ, Donati MB, Donfrancesco C, Donoso SP, Döring A,
Dorobantu M, Dorosty AR, Doua K, Drygas W, Duan JL, Duante C, Duleva V, Dulskiene
JG, la Peña JE, Evans A, Faeh D, Fall CH, Sant'Angelo VF, Farzadfar F,
Ferrari M, Ferreccio C, Ferrieres J, Finn JD, Fischer K, Flores EM, Föger B, Foo
LH, Forslund AS, Forsner M, Fouad HM, Francis DK, Franco MDC, Franco OH, Frontera
Guimaraes AL, Gulliford MC, Gunnlaugsdottir J, Gunter M, Guo X, Guo Y, Gupta PC,
Hihtaniemi IT, Ho SY, Ho SC, Hobbs M, Hofman A, Hopman WM, Horimoto AR, Hormiga
CM, Horta BL, Houti L, Howitt C, Htay TT, Htet AS, Htike MMT, Hu Y, Huerta JM,
Iacoviello L, Iannone AG, Ibarluzea JM, Ibrahim MM, Ikeda N, Ikram MA, Irazola
VE, Islam M, Ismail AA, Ivkovic V, Iwasaki M, Jackson RT, Jacobs JM, Jaddou H,
Kelleher C, Kemper HC, Kengne AP, Kerimkulova A, Kersting M, Key T, Khader YS,
Khalili D, Khang YH, Khateeb M, Khaw KT, Khouw IM, Kiechl-Kohlendorfer U, Kiechl
HS, Kubinova R, Kuciene R, Kuh D, Kujala UM, Kulaga Z, Kumar RK, Kunešová M,
LE, Lauria L, Laxmaiah A, Bao KLN, Le TD, Lebanan MAO, Leclercq C, Lee J, Lee J,
Lehtimäki T, León-Muñoz LM, Levitt NS, Li Y, Lilly CL, Lim WY, Lima-Costa MF, Lin
HH, Lin X, Lind L, Linneberg A, Lissner L, Litwin M, Liu J, Loit HM, Lopes L,
Matsha TE, Mazur A, Mbanya JCN, McFarlane SR, McGarvey ST, McKee M, McLachlan S,
McLean RM, McLean SB, McNulty BA, Yusof SM, Mediene-Benchekor S, Medzioniene J,
Miller JC, Minderico CS, Miquel JF, Miranda JJ, Mirkopoulou D, Mirrakhimov E,
NC, Molnár D, Momenan A, Mondo CK, Monterrubio EA, Monyeki KDK, Moon JS, Moreira
Mostafa A, Mota J, Mota-Pinto A, Motlagh ME, Motta J, Mu TT, Muc M, Muiesan ML,
Naidu BM, Nakamura H, Námešná J, Nang EEK, Nangia VB, Nankap M, Narake S, Nardone
P, Navarrete-Muñoz EM, Neal WA, Nenko I, Neovius M, Nervi F, Nguyen CT, Nguyen
ND, Nguyen QN, Nieto-Martínez RE, Ning G, Ninomiya T, Nishtar S, Noale M, Noboa
OA, Norat T, Norie S, Noto D, Nsour MA, O'Reilly D, Obreja G, Oda E, Oehlers G,
Oh K, Ohara K, Olafsson Ö, Olinto MTA, Oliveira IO, Oltarzewski M, Omar MA, Onat
A, Ong SK, Ono LM, Ordunez P, Ornelas R, Ortiz AP, Osler M, Osmond C, Ostojic SM,
F, Papandreou D, Park SW, Parnell WR, Parsaeian M, Pascanu IM, Patel ND, Pecin I,
Pednekar MS, Peer N, Peeters PH, Peixoto SV, Peltonen M, Pereira AC,
Pitakaka F, Piwonska A, Plans-Rubió P, Poh BK, Pohlabeln H, Pop RM, Popovic SR,
H, Pradeepa R, Prashant M, Price JF, Puder JJ, Pudule I, Puiu M, Punab M, Qasrawi
F, de Wit TFR, Rito A, Ritti-Dias RM, Rivera JA, Robinson SM, Robitaille C,
Sánchez-Abanto J, Sandjaja, Sans S, Marina LS, Santos DA, Santos IS, Santos O,
Dos Santos RN, Santos R, Saramies JL, Sardinha LB, Sarrafzadegan N, Saum KU,
S, Schmidt CO, Schmidt IM, Schultsz C, Schutte AE, Sein AA, Sen A, Senbanjo IO,
Sepanlou SG, Serra-Majem L, Shalnova SA, Sharma SK, Shaw JE, Shibuya K, Shin DW,
Shin Y, Shiri R, Siani A, Siantar R, Sibai AM, Silva AM, Silva DAS, Simon M,
Soekatri MY, Solfrizzi V, Sonestedt E, Song Y, Sørensen TI, Soric M, Jérome CS,
Tamosiunas A, Tan EJ, Tang X, Tanser F, Tao Y, Tarawneh MR, Tarp J, Tarqui-Mamani
Thijs L, Thuesen BH, Tjonneland A, Tolonen HK, Tolstrup JS, Topbas M, Topór-Madry
Tzourio C, Ueda P, Ugel EE, Ukoli FA, Ulmer H, Unal B, Uusitalo HM, Valdivia G,
Vale S, Valvi D, van der Schouw YT, Van Herck K, Van Minh H, van Rossem L, Van
S, Vrijheid M, Wade AN, Wagner A, Waldhör T, Walton J, Bebakar WMW, Mohamud WNW,
Wanderley RS Jr., Wang MD, Wang Q, Wang YX, Wang YW, Wannamethee SG, Wareham N,
Wong-McClure RA, Wong JY, Wong JE, Wong TY, Woo J, Woodward M, Wu FC, Wu J, Wu S,
Paciorek CJ, Chirita-Emandi A, Hayes AJ, Katz J, Kelishadi R, Kengne AP, Khang
Comment in
associated with adverse health consequences throughout the life-course. Our aim
weight on 128·9 million participants aged 5 years and older, including 31·5
million aged 5-19 years. We used a Bayesian hierarchical model to estimate trends
from 1975 to 2016 in 200 countries for mean BMI and for prevalence of BMI in the
following categories for children and adolescents aged 5-19 years: more than 2 SD
below the median of the WHO growth reference for children and adolescents
(referred to as moderate and severe underweight hereafter), 2 SD to more than 1
SD below the median (mild underweight), 1 SD below the median to 1 SD above the
median (healthy weight), more than 1 SD to 2 SD above the median (overweight but
FINDINGS: Regional change in age-standardised mean BMI in girls from 1975 to 2016
ranged from virtually no change (-0·01 kg/m2 per decade; 95% credible interval
-0·42 to 0·39, posterior probability [PP] of the observed decrease being a true
(0·69-1·35, PP>0·9999) in central Latin America and an increase of 0·95 kg/m2 per
decade (0·64-1·25, PP>0·9999) in Polynesia and Micronesia. The range for boys was
Asia-Pacific regions for both sexes, southwestern Europe for boys, and central
and Andean Latin America for girls. By contrast, the rise in BMI has accelerated
in east and south Asia for both sexes, and southeast Asia for boys. Global
5·6% (4·8-6·5) in 2016 in girls, and from 0·9% (0·5-1·3) in 1975 to 7·8%
decreased from 9·2% (6·0-12·9) in 1975 to 8·4% (6·8-10·1) in 2016 in girls and
among girls and 30·7% (23·5-38·0) among boys. Prevalence of obesity was more than
30% in girls in Nauru, the Cook Islands, and Palau; and boys in the Cook Islands,
Nauru, Palau, Niue, and American Samoa in 2016. Prevalence of obesity was about
20% or more in several countries in Polynesia and Micronesia, the Middle East and
north Africa, the Caribbean, and the USA. In 2016, 75 (44-117) million girls and
the same year, 50 (24-89) million girls and 74 (39-125) million boys worldwide
were obese.
INTERPRETATION: The rising trends in children's and adolescents' BMI have
adults.
Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access
article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights
reserved.
DOI: 10.1016/S0140-6736(17)32129-3
PMCID: PMC5735219
Author information:
Animal models of diabetic delayed wound healing are essential to the development
diet-induced obesity and diabetes and we evaluated the utility of the ZDSD rat as
a model for delayed wound healing associated with diabetes and obesity. Groups of
ZDSD and Sprague Dawley (SD) rats were placed on a diabetogenic diet and
evaluated two weeks later for hyperglycemia, as a sign of diabetes. Rats with
blood glucose levels of >300 mg/dl were considered diabetic and those with blood
rats using a punch biopsy and wound diameter measured on days 1, 4, 7, 9 and 11.
Blood glucose levels and body weights were measured periodically before and after
wounding. Diabetic ZDSD rats had significantly greater blood glucose levels than
non-diabetic ZDSD and SD rats within 10 days of being placed on the diabetogenic
diet. Furthermore, diabetic ZDSD rats initially weighed more than non-diabetic
ZDSD and SD rats, however, by the end of the study there was no significant
difference in body weight between the ZDSD groups. By day nine, wounds in ZDSD
rats were significantly larger than those in SD rats and this persisted until the
end of the study at day fourteen. Wounds from all groups were characterized
These results demonstrate delayed wound healing in both diabetic and non-diabetic
ZDSD rats and suggest that obesity or metabolic syndrome are important factors in
DOI: 10.21873/invivo.11025
PMCID: PMC5354148
Writing for Health: Rationale and Protocol for a Randomized Controlled Trial of
Author information:
(1)Faces in the Street, Urban Mental Health Research Institute, St. Vincent's
Sydney, Australia.
Australia.
has high comorbidity with depression. Both subthreshold depression and diabetes
distress are common amongst people with type 1 or type 2 diabetes, and are
self-help interventions for large numbers of people with diabetes and diabetes
is a very brief intervention that involves writing about any positive thoughts
writing has been associated with increases in positive affect and positive
growth, and has demonstrated promising results in trials amongst other clinical
populations. However, benefit-finding writing has not yet been examined in people
with diabetes.
OBJECTIVE: The aim of this randomized controlled trial (RCT) is to evaluate the
METHODS: A two-arm RCT will be conducted, using the online program Writing for
Health. Adults with type 1 or type 2 diabetes living in Australia will be
information and screening. All data will be collected online. Participants will
writing about use-of-time. Both conditions involve three daily sessions (once per
day for three consecutive days) of 15-minute online writing exercises. Outcome
follow-ups.
RESULTS: This trial is currently underway. The primary outcomes will be diabetes
aim to recruit 104 participants. All stages of the study will be conducted online
using the Writing for Health program. Group differences will be analyzed on an
CONCLUSIONS: This RCT will be the first study to examine iBFW for adults with
diabetes distress and improving diabetes self-care and other outcomes, iBFW may
(ACTRN12615000241538).
©Joanna Crawford, Kay Wilhelm, Lisa Robins, Judy Proudfoot. Originally published
DOI: 10.2196/resprot.7151
PMCID: PMC5373675
PMID: 28292741