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1histoire
2Théorie de la résonance magnétique nucléaire
o 2.1Spin nucléaire et aimants
o 2.2Valeurs du moment angulaire de spin
2.2.1Energie de spin dans un champ magnétique
2.2.2Précession de la magnétisation de spin
2.2.3Magnetic resonance and radio-frequency pulses
2.2.4Chemical shielding
o 2.3Relaxation
3NMR spectroscopy
o 3.1Continuous-wave (CW) spectroscopy
o 3.2Fourier-transform spectroscopy
o 3.3Multi-dimensional NMR spectroscopy
o 3.4Solid-state NMR spectroscopy
o 3.5Sensitivity
o 3.6Isotopes
4Applications
o 4.1Medicine
o 4.2Chemistry
o 4.3Purity determination (w/w NMR)
o 4.4Non-destructive testing
o 4.5Segmental and molecular motions
o 4.6Data acquisition in the petroleum industry
o 4.7Flow probes for NMR spectroscopy
o 4.8Process control
o 4.9Earth's field NMR
o 4.10Zero field NMR
o 4.11Quantum computing
o 4.12Magnetometers
o 4.13SNMR
5Makers of NMR equipment
6See also
7References
8Further reading
9External links
o 9.1Tutorial
o 9.2Animations and simulations
o 9.3Video
History[edit]
Nuclear magnetic resonance was first described and measured in molecular beams by Isidor
Rabi in 1938,[2] by extending the Stern–Gerlach experiment, and in 1944, Rabi was awarded
the Nobel Prize in Physics for this work.[3] In 1946, Felix Bloch and Edward Mills Purcell expanded
the technique for use on liquids and solids, for which they shared the Nobel Prize in Physics in
1952.[4][5]
Yevgeny Zavoisky likely observed nuclear magnetic resonance in 1941, well before Felix Bloch
and Edward Mills Purcell, but dismissed the results as not reproducible.
Russell H. Varian filed the "Method and means for correlating nuclear properties of atoms and
magnetic fields", U.S. Patent 2,561,490 on July 24, 1951. Varian Associatesdeveloped the first
NMR unit called NMR HR-30 in 1952.[6]
Purcell had worked on the development of radar during World War II at the Massachusetts
Institute of Technology's Radiation Laboratory. His work during that project on the production and
detection of radio frequency power and on the absorption of such RF power by matter laid the
foundation for his discovery of NMR in bulk matter.
Rabi, Bloch, and Purcell observed that magnetic nuclei, like 1
H
and 31
P
, could absorb RF energy when placed in a magnetic field and when the RF was of a frequency
specific to the identity of the nuclei. When this absorption occurs, the nucleus is described as
being in resonance. Different atomic nuclei within a molecule resonate at different (radio)
frequencies for the same magnetic field strength. The observation of such magnetic resonance
frequencies of the nuclei present in a molecule allows any trained user to discover essential
chemical and structural information about the molecule.
The development of NMR as a technique in analytical chemistry and biochemistry parallels the
development of electromagnetic technology and advanced electronics and their introduction into
civilian use.
also spin particles and hence fermions), giving zero overall spin.
However, a proton and neutron [citation needed] will have lower energy when their spins are parallel, not
anti-parallel. This parallel spin alignment of distinguishable particles does not violate the Pauli
exclusion principle. The lowering of energy for parallel spins has to do with the quark structure of
these two nucleons. As a result, the spin ground state for the deuteron (the nucleus of deuterium,
the 2H isotope of hydrogen), which has only a proton and a neutron, corresponds to a spin value
of 1, not of zero. On the other hand, because of the Pauli exclusion principle, the tritium isotope of
hydrogen must have a pair of anti-parallel spin neutrons (of total spin zero for the neutron-spin
pair), plus a proton of spin 1/2 . Therefore, the tritium total nuclear spin value is again 1/2 , just like
for the simpler, abundant hydrogen isotope, 1H nucleus (the proton). The NMR absorption
frequency for tritium is also similar to that of 1H. In many other cases of non-radioactive nuclei, the
overall spin is also non-zero. For example, the 27
Al
nucleus has an overall spin value S = 5⁄2.
A non-zero spin is always associated with a non-zero magnetic dipole moment, , via
the relation
where γ is the gyromagnetic ratio. Classically, this corresponds to the proportionality between the
angular momentum and the magnetic dipole moment of a spinning charged sphere, both of which
are vectors parallel to the rotation axis whose length increases proportional to the spinning
frequency. It is the magnetic moment and its interaction with magnetic fields that allows the
observation of NMR signal associated with transitions between nuclear spin levels during
resonant RF irradiation or caused by Larmor precession of the average magnetic moment after
resonant irradiation. Nuclides with even numbers of both protons and neutrons have zero nuclear
magnetic dipole moment and hence do not exhibit NMR signal. For instance, 18
O
is an example of a nuclide that produces no NMR signal, whereas 13
C
, 31
P
, 35
Cl
and 37
Cl
are nuclides that do exhibit NMR spectra. The last two nuclei have spin S > 1/2 and are therefore
quadrupolar nuclei.
Electron spin resonance (ESR) is a related technique in which transitions
between electronic rather than nuclear spin levels are detected. The basic principles are similar
but the instrumentation, data analysis, and detailed theory are significantly different. Moreover,
there is a much smaller number of molecules and materials with unpaired electron spins that
exhibit ESR (or electron paramagnetic resonance (EPR)) absorption than those that have NMR
absorption spectra. On the other hand, ESR has much higher signal per spin than NMR does.
Values of spin angular momentum[edit]
Nuclear spin is an intrinsic angular momentum that is quantized. This means that the magnitude
of this angular momentum is quantized (i.e. S can only take on a restricted range of values), and
also that the x, y, and z-components of the angular momentum are quantized, being restricted to
integer or half-integer multiples of ħ. The integer or half-integer quantum number associated with
the spin component along the z-axis or the applied magnetic field is known as the magnetic
quantum number, m, and can take values from +S to −S, in integer steps. Hence for any given
nucleus, there are a total of 2S + 1 angular momentum states.
The z-component of the angular momentum vector ( ) is therefore Sz = mħ, where ħ is the
reduced Planck constant. The z-component of the magnetic moment is simply:
or alternatively:
frequency[7] of
,
without change in the populations of the energy
levels because energy is constant (time-
independent Hamiltonian).[8]
Magnetic resonance and radio-frequency
pulses[edit]
A perturbation of nuclear spin orientations from
equilibrium will occur only when an oscillating
magnetic field is applied whose
frequency νrf sufficiently closely matches
the Larmor precession frequency νL of the
nuclear magnetization. The populations of the
spin-up and -down energy levels then
undergo Rabi oscillations,[7] which are analyzed
most easily in terms of precession of the spin
magnetization around the effective magnetic
field in a reference frame rotating with the
frequency νrf.[9] The stronger the oscillating field,
the faster the Rabi oscillations or the precession
around the effective field in the rotating frame.
After a certain time on the order of 2-1000
microseconds, a resonant RF pulse flips the
spin magnetization to the transverse plane, i.e. it
makes an angle of 90o with the constant
magnetic field B0 ("90o pulse"), while after a
twice longer time, the initial magnetization has
been inverted ("180o pulse"). It is the transverse
magnetization generated by a resonant
oscillating field which is usually detected in
NMR, during application of the relatively weak
RF field in old-fashioned continuous-wave NMR,
or after the relatively strong RF pulse in modern
pulsed NMR.
Chemical shielding[edit]
It might appear from the above that all nuclei of
the same nuclide (and hence the same γ) would
resonate at exactly the same frequency. This is
not the case. The most important perturbation of
the NMR frequency for applications of NMR is
the "shielding" effect of the surrounding shells of
electrons.[10] Electrons, similar to the nucleus,
are also charged and rotate with a spin to
produce a magnetic field opposite to the applied
magnetic field. In general, this electronic
shielding reduces the magnetic field at the
nucleus (which is what determines the NMR
frequency). As a result, the frequency required
to achieve resonance is also reduced. This shift
in the NMR frequency due to the electronic
molecular orbital coupling to the external
magnetic field is called chemical shift, and it
explains why NMR is able to probe the chemical
structure of molecules, which depends on the
electron density distribution in the corresponding
molecular orbitals. If a nucleus in a specific
chemical group is shielded to a higher degree
by a higher electron density of its surrounding
molecular orbital, then its NMR frequency will be
shifted "upfield" (that is, a lower chemical shift),
whereas if it is less shielded by such
surrounding electron density, then its NMR
frequency will be shifted "downfield" (that is, a
higher chemical shift).
Unless the local symmetry of such molecular
orbitals is very high (leading to "isotropic" shift),
the shielding effect will depend on the
orientation of the molecule with respect to the
external field (B0). In solid-state
NMR spectroscopy, magic angle spinning is
required to average out this orientation
dependence in order to obtain frequency values
at the average or isotropic chemical shifts. This
is unnecessary in conventional NMR
investigations of molecules in solution, since
rapid "molecular tumbling" averages out
the chemical shift anisotropy(CSA). In this case,
the "average" chemical shift (ACS) or isotropic
chemical shift is often simply referred to as the
chemical shift.
Relaxation[edit]
Further information: Relaxation (NMR)
NMR spectroscopy[edit]
Main article: NMR spectroscopy
900 MHz, 21.2 T NMR Magnet at HWB-NMR,
Birmingham, UK
1
H
, the most commonly used spin-1/2 nucleus
in NMR investigation, has been studied
using many forms of NMR. Hydrogen is
highly abundant, especially in biological
systems. It is the nucleus most sensitive to
NMR signal (apart from 3
H
which is not commonly used due to its
instability and radioactivity). Proton NMR
produces narrow chemical shift with sharp
signals. Fast acquisition of quantitative
results (peak integrals in stoichiometric
ratio) is possible due to short relaxation
time. The 1
H
signal has been the sole diagnostic nucleus
used for clinical magnetic resonance
imaging.
2
H
, a spin 1 nucleus commonly utilized as
signal-free medium in the form
of deuterated solvents during proton NMR,
to avoid signal interference from hydrogen-
containing solvents in measurement of 1
H
solutes. Also used in determining the
behavior of lipids in lipid membranes and
other solids or liquid crystals as it is a
relatively non-perturbing label which can
selectively replace 1
H
. Alternatively, 2
H
can be detected in media specially labeled
with 2
H
. Deuterium resonance is commonly used in
high-resolution NMR spectroscopy to
monitor drifts in the magnetic field strength
(lock) and to improve the homogeneity of
the external magnetic field.
3
He
, is very sensitive to NMR. There is a very
low percentage in natural helium, and
subsequently has to be purified from 4
He
. It is used mainly in studies of endohedral
fullerenes, where its chemical inertness is
beneficial to ascertaining the structure of the
entrapping fullerene.
11
B
, more sensitive than 10
B
, yields sharper signals. Quartz tubes must
be used as borosilicate glass interferes with
measurement.
13
C
spin-1/2 , is widely used, despite its relative
paucity in naturally occurring carbon
(approximately 1.1%). It is stable to nuclear
decay. Since there is a low percentage in
natural carbon, spectrum acquisition on
samples which have not been
experimentally enriched in 13
C
takes a long time. Frequently used for
labeling of compounds in synthetic and
metabolic studies. Has low sensitivity and
moderately wide chemical shift range, yields
sharp signals. Low percentage makes it
useful by preventing spin-spin couplings
and makes the spectrum appear less
crowded. Slow relaxation means that
spectra are not integrable unless long
acquisition times are used.
14
N
, spin-1, medium sensitivity nucleus with
wide chemical shift. Its
large quadrupole moment interferes in
acquisition of high resolution spectra,
limiting usefulness to smaller molecules and
functional groups with a high degree of
symmetry such as the headgroups of lipids.
15
N
, spin-1/2 , relatively commonly used. Can be
used for labeling compounds. Nucleus very
insensitive but yields sharp signals. Low
percentage in natural nitrogen together with
low sensitivity requires high concentrations
or expensive isotope enrichment.
17
O
, spin-5/2 , low sensitivity and very low
natural abundance (0.037%), wide chemical
shift range (up to 2000 ppm). Quadrupole
moment causing line broadening. Used in
metabolic and biochemical studies in
studies of chemical equilibria.
19
F
, spin-1/2 , relatively commonly measured.
Sensitive, yields sharp signals, has a wide
chemical shift range.
31
P
, spin-1/2 , 100% of natural phosphorus.
Medium sensitivity, wide chemical shifts
range, yields sharp lines. Spectra tend to
have a moderate amount of noise. Used in
biochemical studies and in coordination
chemistry where phosphorus containing
ligands are involved.
35
Cl
and 37
Cl
, broad signal. 35
Cl
is significantly more sensitive, preferred
over 37
Cl
despite its slightly broader signal. Organic
chlorides yield very broad signals. Its use is
limited to inorganic and ionic chlorides and
very small organic molecules.
43
Ca
, used in biochemistry to study calcium
binding to DNA, proteins, etc. Moderately
sensitive, very low natural abundance.
195
Pt
, used in studies of catalysts and
complexes.
Other nuclei (usually used in the studies of
their complexes and chemical bonding, or to
detect presence of the element):
6
Li
,7
Li
9
Be
19
21
Ne
23
Na
25
Mg
27
Al
29
Si
31
33
39
K
, 40
K
, 41
K
45
Sc
47
Ti
, 49
Ti
50
V
, 51
V
53
Cr
55
Mn
57
Fe
59
Co
61
Ni
63
Cu
, 65
Cu
67
Zn
69
Ga
, 71
Ga
73
Ge
75
As
77
Se
81
Br
87
Rb
87
Sr
95
Mo
109
Ag
113
Cd
119
Sn
125
Te
127
133
Cs
135
Ba
, 137
Ba
139
La
183
199
Hg
Applications[edit]
NMR is extensively used in medicine in the form
of magnetic resonance imaging. NMR is used
industrially mainly for routine analysis of
chemicals. The technique is also used, for
example, to measure the ratio between water
and fat in foods, monitor the flow of corrosive
fluids in pipes, or to study molecular structures
such as catalysts.[20]
Medicine[edit]
Medical MRI
Where:
Electron-mediated heteronuclear J-
couplings (spin-spin couplings) are field
independent, producing clusters of two
or more frequencies separated by
several Hz, which are more easily
observed in a fundamental resonance
of about 2 kHz."Indeed it appears that
enhanced resolution is possible due to
the long spin relaxation times and high
field homogeneity which prevail in
EFNMR."[25]
Chemical shifts of several ppm are
clearly separated in high field NMR
spectra, but have separations of only a
few millihertz at proton EFNMR
frequencies, so are usually not
resolved.
Zero field NMR[edit]
Main article: Zero field NMR
In zero field NMR all magnetic fields are
shielded such that magnetic fields below
1 nT (nanotesla) are achieved and the
nuclear precession frequencies of all nuclei
are close to zero and indistinguishable.
Under those circumstances the observed
spectra are no-longer dictated by chemical
shifts but primarily by J-coupling interactions
which are independent of the external
magnetic field. Since inductive detection
schemes are not sensitive at very low
frequencies, on the order of the J-couplings
(typically between 0 and 1000 Hz),
alternative detection schemes are used.
Specifically, sensitive magnetometers turn
out to be good detectors for zero field NMR.
A zero magnetic field environment does not
provide any polarization hence it is the
combination of zero field NMR with
hyperpolarization schemes that makes zero
field NMR attractive.
Quantum computing[edit]
Main article: Nuclear magnetic resonance
quantum computer
NMR quantum computing uses
the spin states of nuclei within molecules
as qubits. NMR differs from other
implementations of quantum computers in
that it uses an ensemble of systems, in this
case molecules.
Magnetometers[edit]
Main article: Magnetometer
Various magnetometers use NMR effects to
measure magnetic fields, including proton
precession magnetometers (PPM) (also
known as proton magnetometers),
and Overhauser magnetometers. See
also Earth's field NMR.
SNMR[edit]
Main article: SNMR
Surface magnetic resonance (or magnetic
resonance sounding) is based on the
principle of Nuclear magnetic resonance
(NMR) and measurements can be used to
indirectly estimate the water content of
saturated and unsaturated zones in the
earth's subsurface.[26] SNMR is used to
estimate aquifer properties, including
quantity of water contained in
the aquifer, Porosity,and Hydraulic
conductivity .
Makers of NMR
equipment[edit]
Major NMR instrument makers
include Thermo Fisher
Scientific, Magritek, Oxford
Instruments, Bruker, Spinlock SRL, General
Electric, JEOL, Kimble
Chase, Philips, Siemens AG, and
formerly Agilent Technologies, Inc. (who
own Varian, Inc.).
See also[edit]
Benchtop NMR spectrometer
Carbon-13 NMR
Chemical shift
Dynamic nuclear polarisation (DNP)
Earth's field NMR (EFNMR)
Free induction decay (FID)
In vivo magnetic resonance
spectroscopy (MRS)
J-coupling
Larmor equation (Not to be confused
with Larmor formula).
Larmor precession
Liquid nitrogen
Low field NMR
Magic angle spinning
Magnetometer
Magnetic resonance imaging (MRI)
Magnetic resonance (quantum
mechanics) for physical & mathematical
understanding
NMR crystallography
NMR spectra database
NMR spectroscopy
NMR Microscopy
Nuclear magnetic resonance in porous
media
Nuclear quadrupole resonance (NQR)
Protein dynamics
Protein NMR
Proton NMR
Rabi cycle
Relaxometry
Relaxation (NMR)
Spin echo
Solid-state NMR
Structure-based assignment
Zero field NMR
SNMR
References[edit]
1. ^ Jump up to:a b D. I. Hoult, B. Bhakar,
"NMR Signal Reception: Virtual
Photons and Coherent Spontaneous
Emission", Concepts Magn. Reson. 9,
277-297, 1997.
2. ^ Rabi, I.I.; Zacharias, J.R.; Millman, S.
& Kusch, P. (1938). "A New Method of
Measuring Nuclear Magnetic
Moment". Physical Review. 53 (4):
318–
327. Bibcode:1938PhRv...53..318R. doi
:10.1103/PhysRev.53.318.
3. ^ Biography of I. Rabi at Nobelprize.org
4. ^ Filler, Aaron (2009). "The History,
Development and Impact of Computed
Imaging in Neurological Diagnosis and
Neurosurgery: CT, MRI, and
DTI". Nature
Precedings. doi:10.1038/npre.2009.326
7.5.
5. ^ 1952 Nobel Prize for Physics at
Nobelprize.org
6. ^ "From X-rays to DNA: How
Engineering Drives Biology". 2013-11-
15: 161–162. ISBN 9780262019774.
7. ^ Jump up to:a b c C. Cohen-Tannoudji,
B. Diu, F. Laloe, Quantum Mechanics,
Vol. 1, Wiley VCH, 1977.
8. ^ R. P. Feynman, R. B. Leighton, M.
Sands, The Feynman Lectures in
Physics, Vol. 3.
9. ^ Jump up to:a b A. Abragam, The
Principles of Nuclear Magnetism, Ch. 2,
Oxford Clarendon Press, 1961.
10. ^ Principle of Shielding and
Deshielding. NMRCentral.com (August
2011)
11. ^ Quantum automaton and quantum
computation (see also references
therein)
12. ^ Vandersypen, Lieven M. K.; Steffen,
Matthias; Breyta, Gregory; Yannoni,
Costantino S.; Sherwood, Mark H.;
Chuang, Isaac L. (2001). "Experimental
realization of Shor's quantum factoring
algorithm using nuclear magnetic
resonance". Nature. 414 (6866): 883–
887. arXiv:quant-
ph/0112176. Bibcode:2001Natur.414..8
83V. doi:10.1038/414883a. PMID 1178
0055.
13. ^ Brian M. Tissue (1996). "Nuclear
Magnetic Resonance (NMR)
Spectroscopy". Technische Universitaet
Braunschweig.
14. ^ "2nd Annual Practical Applications of
NMR in Industry Conference (PANIC)
Announced". Process NMR. 2014.
15. ^ Derek Lowe (October 22, 2010). "The
Latest Technology".
16. ^ Ryogo Kubo; Kazuhisa Tomita
(1954). "A General Theory of Magnetic
Resonance Absorption". Journal of the
Physical Society of Japan. Physical
Society of Japan. 9 (6): 888–
919. Bibcode:1954JPSJ....9..888K. doi:
10.1143/JPSJ.9.888.
17. ^ "Nuclear Magnetic Resonance
Fourier Transform
Spectroscopy" Ernst's Nobel lecture.
(Includes mention of Jeener's
suggestion.)
18. ^ Baianu, I.C. "Two-dimensional
Fourier transforms". 2D-FT NMR and
MRI. PlanetMath. Retrieved 2009-02-
22.
19. ^ Multinuclear NMR
20. ^ "Chapter Nineteen Non-Medical
Applications of NMR and
MRI". Magnetic Resonance(11 ed.).
June 2017. Retrieved 2017-12-18.
21. ^ Taylor, R.; Hare, J.P.; Abdul-Sada,
A.K. & Kroto, H.W. (1990). "Isolation,
separation and characterization of the
fullerenes C60 and C70: the third form of
carbon". Journal of the Chemical
Society, Chemical
Communications. 20 (20): 1423–
1425. doi:10.1039/c39900001423.
22. ^ K. Schmidt-Rohr, H. W. Spiess,
Multidimensional Solid-State NMR and
Polymers, Ch. 2, Academic Press,
1994.
23. ^ Kleinberg, Robert L.; Jackson, Jasper
A. (2001-01-01). "An introduction to the
history of NMR well logging". Concepts
in Magnetic Resonance. 13 (6): 340–
342. doi:10.1002/cmr.1018. ISSN 1099-
0534.
24. ^ Haner, R.L. & Keifer, P.A. (2009).
"Flow Probes for NMR
Spectroscopy". Encyclopedia of
Magnetic
Resonance. doi:10.1002/97804700345
90.emrstm1085. ISBN 0470034599.
25. ^ Robinson J. N.; et al. (2006). "Two-
dimensional NMR spectroscopy in
Earth's magnetic field" (PDF). Journal of
Magnetic Resonance. 182 (2): 343–
347. Bibcode:2006JMagR.182..343R. d
oi:10.1016/j.jmr.2006.06.027. PMID 168
60581.
26. ^ Anatoly Legtchenko(2013)Magnetic
Resonance Imaging for Groundwater
wiley, New york city
Further reading[edit]
John D. Roberts (1959). Nuclear
Magnetic Resonance : applications to
organic chemistry. McGraw-Hill Book
Company. ISBN 9781258811662.
J.A.Pople; W.G.Schneider;
H.J.Bernstein (1959). High-resolution
Nuclear Magnetic Resonance. McGraw-
Hill Book Company.
A. Abragam (1961). The Principles of
Nuclear Magnetism. Clarendon
Press. ISBN 9780198520146.
Charles P. Slichter (1963). Principles of
magnetic resonance: with examples
from solid state physics. Harper &
Row. ISBN 9783540084761.
John Emsley; James Feeney; Leslie
Howard Sutcliffe (1965). High
Resolution Nuclear Magnetic
Resonance Spectroscopy.
Pergamon. ISBN 9781483184081.
David M. Grant; Robin Kingsley Harris
(2002). Encyclopedia of Nuclear
Magnetic Resonance: Advances in
NMR. John
Wiley. ISBN 9780471490821.
Gary E. Martin; A. S. Zektzer
(1988). Two-Dimensional NMR
Methods for Establishing Molecular
Connectivity. New York: Wiley-VCH.
p. 59. ISBN 0-471-18707-0.
J.W. Akitt; B.E. Mann (2000). NMR and
Chemistry. Cheltenham, UK: Stanley
Thornes. pp. 273, 287. ISBN 0-7487-
4344-8.
G.M. Clore; A.M. Gronenborn (1991).
"Structures of larger proteins in solution:
three- and four-dimensional
heteronuclear NMR
spectroscopy". Science. 252 (5011):
1390–
1399. doi:10.1126/science.2047852. P
MID 2047852.
J.P. Hornak. "The Basics of NMR".
Retrieved 2009-02-23.
J. Keeler (2005). Understanding NMR
Spectroscopy. John Wiley &
Sons. ISBN 0-470-01786-4.
Kurt Wüthrich (1986). NMR of Proteins
and Nucleic Acids. New York (NY),
USA: Wiley-Interscience. ISBN 0-471-
11917-2.
J.M. Tyszka; S.E. Fraser; R.E. Jacobs
(2005). "Magnetic resonance
microscopy: recent advances and
applications". Current Opinion in
Biotechnology. 16 (1): 93–
99. doi:10.1016/j.copbio.2004.11.004. P
MID 15722021.
R.L. Haner; P.A. Keifer
(2009). Encyclopedia of Magnetic
Resonance. John
Wiley. doi:10.1002/9780470034590.emr
stm1085.
External links[edit]
Wikimedia Commons has
media related to Nuclear
magnetic resonance.
Tutorial[edit]
NMR/MRI tutorial
NMR Library NMR Concepts
NMR Course Notes
Animations and simulations[edit]
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