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CONTENT
INTRODUCTION
DEFINITION
DETERMINATION OF PARTITION COEFFICIENT
GENERAL FEATURES
LIMITATION
REFERENCE
‘p’=SA/SB
In which
SA means solubility of a compound in phase A
SB means solubility of a compound in phase B
The org.phase usally chloroform and aq. Phase usally water
Divided conc of org.phase and aq.phase.
• HPLC method.
separated.
Standard dilutions are prepared.
Disadvantages:
Time consuming(>30min per sample)
logP values.
HPLC is performed on analytical columns packed with a commercially
Disadvantages:
Since the logP value is determined by linear regression,
membrane.
solvent.
Equilibrium concentration: This is achieved by shaking the mixture for
longer time.
Non-miscibility of solvents: So, the solvents are to be allowed for separation