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1. A known asthmatic presented with wheezing and difficulty in breathing.

His respiratory rate


was 46/min. Nebulization with a beta agonist improved his symptoms.

1.1 Briefly outline the autonomic regulation of bronchial tone. (20 marks)

1.2 State the physiological basis for his

a) wheezing. (15 marks)


b) increased respiratory rate. (25 marks)

1.3 Briefly explain why his symptoms improved following nebulization with a beta- agonist. (10marks)

2.

2.1 List the factors affecting gas exchange at the alveolar capillary membrane. (30 marks)

2.2 Explain the significance of elevated 2,3- DPG levels in red cells among populations living at high
altitude. ( 20 marks)

Explain the effect of carbon dioxide on the O-Hb dissociation curve. (20 marks)

3.

3.1 Describe the regulation of respiration while resting. (35 marks)

3.2 Describe briefly the regulatory mechanisms that return her breathing pattern to normal after she
has been frightened. (25 marks)

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