What is Genetics? What is DNA?

Cancer formation, genetic predisposition has prepared the ground, according to scientific data is no longer so
obvious. We are one of the questions most frequently posed to physicians "Cancer Is a hereditary disease?"
no, too simple an answer to the question, but unfortunately, neither scientifically nor can say yes to this
question is no. All over the world, is almost developed cancer in one out of every four people, almost all
people have cancer in the first or second degree relatives, in this case may have cancer you in one of your
first degree relatives, but there is cancer in a person in your family so you'll be just you also cancer was a
definite No provisions. Environmental factors with genetic factors are a range of cancer affects almost
preparers as two separate ends, but both are part of the same spectrum at the same time.

However, the hereditary tumors have revealed an entirely genetic reasons. Genetic factors in the
development of these tumors, genetic predisposition far more than I just mentioned. Most of autosomal
dominant type we call she shows genetic and usually have problems in cancer suppressor gene in this type of
cancer occurring in infancy. These as well as cancers of the cancer suppressor gene that has been created
through matter. Our bodies actually are many defense mechanisms against cancer, the cancer suppressor
genes and also is such a genetic or acquired defects in these genes revealed an axonal cancer.

We give the name of familial polyposis coli and almost all members of the family, the inner surface of the
colon, which appears likely to turn to the future of cancer called intestinal polyp structure extending
outwardly from the high internal surface, there is a genetic disease. This almost up to the age of 50 in all
colon cancer patients is formed. This is the last of a genetic disease with a dominant gene that is dominant.

There is also a reflection recessive inherited tumor samples with a recessive gene that gave them the best we
xeroderma pigmentosum name and with the sun's rays consist of skin cancer is a disease easily. There are a
number of defects in DNA repair in disease and they are exposed to doses of sunlight, even normal people
will not develop skin cancer skin cancer in these people immediately. Important contribution to the science
of such diseases, the existing DNA repair mechanisms in our bodies is that they allow us to be aware of.
DNA damage in our bodies just happens every day, but our team defense mechanism against cancer DNA
repair our engaged and we do not have cancer. Repair of DNA damage, plays a key role in the prevention of
cancer; because, as I will discuss in detail shortly, on the basis of non-lethal DNA damage in cancer lies.
This is the key word; non-lethal DNA damage.

Age is also an important factor in the development of cancer. Although overall cancer incidence increases
with age, some types of cancer are more common in certain age. For example, while blood count should
come first in our mind we found a baby low iron deficiency anemia in our mind an old man admitted to the
same complaint must come first stomach and intestinal cancers. Conversely, impaired vision and pupillary in
which an elderly grandfather presented with whitish discoloration, which should arrive in our thoughts that
cause non-cancer, cataract, this finding is in an infant under 2 years of age is a genetic eye cancer we call the
retinoblastoma name should come to mind. Age, guiding us about the location and type of cancer is an
important clue to the diagnosis and shorten the time spent tile corresponds.

Cancer Suppressor Gene: Natural Genetic Our Defense

Genetic variation is the most important initial step in cancer formation mechanisms. In almost all human
cancers analyzed, in some cancer-causing genes called oncogenes that we call cancer suppressor gene
activation or from one or more of the genetic changes such as suppression is determined. Our bodies are in
perfect balance so that our cells are made on the one hand, on the other hand destroyed.

The fight against the destruction with this structure, the womb starts to the moment we fall, our body, also
met with more structure, while the embryo, also with destruction. This construction and occurs when cancer
is broken in favor of making the balance between destruction. Cancer is the abnormal cell proliferation, but
also is essential for normal cell growth we can make to sustain our lives. Normally, we have too often
isolated tissue consisting of cells, such as bone marrow tissue, red blood cells and white blood cells from the
rest of us never stop trains. Used and destroyed red blood cells and white blood cells are destroyed and
destroyed those who constantly made us rather than new bone marrow. Our skin and mouth to the anus so
that our continuous surface coating is made, destroyed, and again, they made again. If cell growth, our body
not to grow could afford no repair occurs, our work will not shut down, bleeding we will not stop, hair we
could extend our nails, our tissues can not be renewed, disease would not heal, most of all, would not the
kids grow up. However, construction and demolition so that has to be in a delicate balance, a little to one
side Kays, it will be a lot of upset balance in the body, the cancer is just one of them. This is to maintain the
delicate balance of the body has many defense mechanisms.

There are many cancer suppressor genes in our body, the first of them, the retinoblastoma tumor is
discovered during the investigation of the eye seen in infancy. This gene, which would then be given the
abbreviated name of the retinoblastoma gene Rb word, was formed in the eye cells and suppresses the cancer
gene mutations When this occurs consisted of this special type of eye cancer. Some diseases are analyzed,
incidentally, one of the body's hidden miraculous discovery mechanism, that retinoblastoma is one of the
most striking examples.

This cancer is a complex operation suppressor genes so that the details of these roads do not even known by
every medical doctor who are not specialized. I just want you to summarize; you startled glory occurring in
your body, once again amazed mold creative, complex as you overwhelmed by its size and a so magnificent
... single outgoing growth stimuli in each cell, chemical transmitters that transmit this information, as well as
the cell membrane to detect them sensors in the core level, closing doors opened with a spectacular key-lock
system of sensors, chemical keys and passwords ... the signal line of the core of the genetic code, copy
editor, on their DNA replicating proteins on impact but growth signals to suppress the signals paths which
signals stimulate growth suppressor genes and their protein products, their collisions with one cell door, etc.
etc. tumor suppressor genes, etc. Basically, this growth stimulators and inhibitors of the dilemma, they
encode the various components that suppress the growth of the party.

Guard of our genes: P53

Genetic guard nicknamed the p53 gene is the most famous VJ cancer suppressor gene Rb gene after. This
gene on chromosome 17 sitting on a gene is very well studied. Many human tumors p53 gene is the only
goal of the genetic change. The head of the causes of suffering lung cancer deaths, breast and homozygous
in this gene in almost every type of colon tumors (predominantly) are missing. Genes are double-stranded, it
must not change in both arms of the DNA double helix is a left-dominant gene. So for example, a mutation
that inactivates both copies of the p53 gene is a colon cell (the genetic alteration) developed, then cell debris
out of the way of growth can not be suppressed, always divided is divided is divided and then millions of
cells, and then the big, invading surrounding a Reveals audience.

These two growth suppressor genes Rb and p53 genes, which we call the cell nucleus and cell cycle effects
would name, blocking the two cells entered and exited the cell reproductive cycle in a cell. Rb gene is found
in all cells and stimulate growth-suppressing opposition, while growth suppression in favor of dengeler.p53
gene acts just like EMERGENCY BRAKE SYSTEM. Not always, if you are exposed to cancer-causing cell
damage such as a chemical substance or radiation activated. P53 is a genetic pathology guard nicknamed the
gene protects the cell genome, the guard is almost done and deserves this moniker until the end of this tiny
miracle molecules in protein structure, how? When the cell's genetic material to such an attack, p53 protein
rapidly accumulates in the cell nucleus and the first phase of the reproductive cycle of nude Glen amount of
phase, so you do not pass on to other phases of the cell proliferation and can not reproduce by dividing in
two. However, this event is not a simple function of the p53 protein, alone, hundreds of signaling proteins
for the activation of the brake system, the sensor and the enzyme is activated, p53 is the head of this
magnificent orchestra literally. P53 carried out, this pause in the cell cycle, DNA creates carcinogenic factor
that gives the cell time to repair the damage that is not lethal.

As I mentioned earlier, non-lethal damage in DNA, cancer is the main reason for the formation of lethal
damage already he finishes the cell, and behind, the way out, there is no cells will turn into cancer by urea
without pause, there is no problem with that. P53 gene is activated during the repair of DNA and organize
the production of the enzymes required for the repair of DNA repair, because these enzymes are always
ready for a wait, they are copied and reproduced as needed. What gets if damaged DNA is repaired, if
repaired, this time p53, cell apoptosis that activates the suicide gene and repaired too highly damaged DNA
with the cells, however, after the mechanism inside some complex cells, allows the self-destruction; commits
suicide damaged cells and prevents the formation of cancer. How much not a great system?

Suicide-Apoptotic Cells

The cells are not also commits suicide. And this event is one of the most powerful defenses against cancer of
the body. Programmed cell death called apoptosis describes the pathology. Apoptosis is an ancient Greek
term literally, falling leaves of the tree, that means the casting sheet. Cell proliferation, cell survival and
reproduction does not mean the same thing. Cell proliferation, growth and stimulate growth, the gene that
prevents the division were stabilized with partners and work in harmony, living cells, apoptosis is regulated
by a combined operation of stimuli and inhibits gene. Apoptosis is a physiological, not pathological, that is
something that should be normal body balance. Should die, the function finished, end of life or degenerated,
commits suicide injured cells, such as defoliation in each autumn.

Apoptosis cell suicide that term was used first in 1972, he did not know until the day of the same whole cell
death. However, the first defined cell death necrosis, external factors mean the destruction of the result of the
cell, while the apoptosis cells purely internal mechanism without external influences is destroying itself and
other cells around an inflammatory Unlike the death of tissue response does not occur, so the cells disappear
unobtrusively quiet . Apoptosis, called death receptors are stimulated by a number of active sensors which
are structurally similar to each other, TNF-alpha (tumor melting factor) and Fas receptors specific names of
their most well known. Receptor, which means detector, the death sensors of your head that it contains a
divine architecture turns physical structure ... hidden in the nook to be seen even in normal microscope, but
the electron microscope is done so we can see the stored almost buried millimeter in the cell membrane
which is thinner than one thousandth. This death receptors, clinging to the cell membrane, out of one end of
the cell, staring into the cell a tip side in the cell apoptosis that is a DEATH DOMAIN organized so that
ignited the system to perform cell suicide that are sensor attached to the death zone. If the cell membrane
outer surface there are some other key-lock mechanisms, stimuli that cause apoptosis when they put the key
into the lock, it takes three-dimensional another state sensors in cell membranes and interact with
intracellular, as such, will ignite a chain linked together a series of reactions and apoptosis occurs.

Apoptosis, that is quite a large family of genes that regulate the cell suicide, but two of them are very famous
in the medical world; bcl-2 and bax. Bcl-2, while preventing apoptosis is still filled with a complex
mechanism that can not be fully explained, bax, this effect is the opposite way to push cell death. This duo's
settings, must be the same as a very delicate jewelery scales in balance with the fine-tuning; or if we have
cancer, or we do not lose our vital cell location. How much governed by a delicate balance, which gives no
chance to say a coincidence, not a magnificent mechanism, our eyes literally puts the power of creative
knowledge.

The importance of genetics in the regulation of cell suicide is far beyond the complexity and grandeur in
practice, because herbal and chemical Many chemotherapy agent, or even food, spices The effectiveness of
apoptosis in tumor cells that are based on the ability to induce cell suicide. P53 mutations in the genes, so
this mechanism lies at the basis of the resistance to treatment with certain agents in tumors with genetic
changes. Because these agents stimulate the cells via p53 suicide; however, you will not find in the p53 gene
can induce changes in this gene when they act against that. Each treatment is the reason for this striking
example to show the same effect in each patient is only one.

DNA Repair Mechanisms

We plunge into the sea at a carcinogen while maintaining our normal lives. What if we can not escape
attention so let's have a full carcinogenic factors in our environment. To be able to prevent cancer, always,
stay away from cigarettes, not mathematically so that the warning lung cancer unfortunately. Mobile phones
in the radioactive hazard has a full mechanism hidden radiate around Although posting a scapegoat, hold the
standing recipient apartment the tops of the electronic device of the major shopping malls, and even
airplanes even radiation source we get to close distant. In the analysis, in the face of an unborn baby's
amniotic fluid was found even dozens of carcinogens, so that we meet the safest place in the womb with
carcinogenic.

When it comes to what we eat, cook a healthy meal we enamel or Teflon pots scratched a vegetable with
cancer-protective properties itself can even be carcinogenic. Coffee, a drink is actually justified, an
important antioxidant and cancer-protective against many diseases that Alzheimer's can only be in the WHO
(World Health Organization) has put him in a low-risk group of carcinogens that can cause cancer. The truth
is that, in fact, too much coffee you are roasting, you collars, jet black coffee beans that they become
cancerous. So the so-called black, and the world famous coffee shops have problems with strong coffee she
offered coffee, preparation technique that is still doing a carcinogenic substance.

Or, almost proved a very valuable spice still be protective against cancer, due to the storage conditions, he
can become carcinogenic, or healthy he morning juice squeezing a detox vegetables we drink or the fruit of a
lot of chemical agriculture is trained using drugs again, this vegetable itself to cancer can cause, especially if
you have a problem that is useful because even what we consume. the result; We did not run away, do not
run and will not escape.

Fortunately, God has created us inherently protected against these factors. Sunlight turns out, exhaust fumes
and cigarette breathing, eating the things known to cause cancer and do not have cancer, who does not? 3 out
of 4 people in the world. Situation is also around, judging by the positive way, if a period in a way getting a
diagnosis of cancer every 4 persons with if life, from 4 people 3 also sheltered means against this disease
that statistically, as well as these people although he faces in a carcinogenic sea. So how is it that lucky
group of cancer, although it is not exposed to all this? I can only answer this question if necessary with a few
words to summarize; cancer cells formed as a result of our damage in DNA carries the genetic code malaria
and we have our natural DNA repair mechanisms, the secret lies in doing business here, if we can repair our
DNA damage, we do not have cancer!

Dna Repair Genes

DNA repair genes protective role against the development of cancer appeared for the first time during the
discovery of a syndrome. In this syndrome, the HNPCC name, birth, there was a genetic problem in the
DNA repair gene family in humans, a large number of polyps in the large intestine (pre- cancerous) occurs
and it also becomes a large part of the cancer of these polyps. This was a very important discovery, but
consisted tendency to cause colon cancer in particular could not exactly find the answer to this problem,
some still do not have a clear answer. Have the guts needed in DNA repair? No, okay, one of the most
intense renewal of intestinal cells and DNA injuries associated, but his stomach and mouth disease in this
protected surface, not been described. This leads us to DNA repair, what we have discovered so far indicate
that much more complex and detailed, evidence that one of the diseases associated with other DNA repair
defects in the formation of cancer in other organs. For example, you still have a problem with another
disease Xeroderma for repairing DNA damage of his pigmentosus sunlight me that there are problems in the
past and still inherited DNA repair. People doomed to skin cancer so long as the sun, whereas in this disease,
and we get the sun, but do not overdo it as long as we have cancer, not even a part of those who exaggerate
surprisingly cancer. The remaining skin cells from UV light exposure to sunlight, provide a DNA molecule
in the cell nucleus called pyrimidine in the formation of cross-links, pyrimidine is also an essential protein in
the DNA regeneration and thus develop DNA damage. This damage occurs, it starts instantly repaired by
nucleotide excision repair system and we, even though we get the sun, so we do not have cancer to be able to
repair our DNA, our genetic code.

In my articles, we will mend and repair system that will keep you healthy individual will talk about the
natural shield. A lot of food, spices, herbs and medicines, by activating these systems, they protect us against
cancer, so in fact we are already fired up our natural defense mechanism.