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SPACECRAFT CRASH

Soyuz emergency
spells trouble for ISS
TWO EGGS, ONE BABY
Same-sex mice reproduce.
Are we next?
EARLIEST ANIMAL
Unusual fossil reveals
surprising origins
WEEKLY October 20 – 26, 2018

THE
POWER
OF
FASTING Why an empty plate
may hold the secret to
a longer life

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LUCY HAWKING 4 2

On her father’s extraordinary legacy


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CONTENTS
newscientist.com/issue/3200

Management
Executive chairman Bernard Gray
Chief executive Nina Wright
Finance director Jenni Prince
Chief technology officer Chris Corderoy
Marketing director Jo Adams
Human resources Shirley Spencer
Non-executive director Louise Rogers

VITALY KOROVIN/SHUTTERSTOCK
Publishing and commercial

JONAS BENDIKSEN/MAGNUM
Customer services manager Gavin Power
HR co-ordinator Serena Robinson
Facilities manager Ricci Welch
Executive assistant Sarah Gauld
Receptionist Alice Catling

Display advertising
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Email displayads@newscientist.com
Commercial director Chris Martin Volume 240 No 3200 This week Time to adapt to a warming world 5
Richard Holliman, Justin Viljoen,
Henry Vowden, Helen Williams

Recruitment advertising On the cover Leaders Features


Tel +1 617 283 3213
Email nssales@newscientist.com 25 Spacecraft crash 3 We must ensure that data-driven 30 The fashion for fasting
Recruitment sales manager Mike Black
Soyuz emergency medicine puts patients first. The Why an empty plate may hold
Key account manager Viren Vadgama
US sales manager Jeanne Shapiro spells trouble for ISS joy of moonmoons the secret to a longer life
Marketing
34 Full steam ahead
Head of marketing Lucy Dunwell 13 Two eggs, one baby Cracking the immense promise
David Hunt, Chloe Thompson Same-sex mice reproduce.
News of geothermal power
Web development Are we next? 4 THIS WEEK Adapting to a 38 The disassembly line
Maria Moreno Garrido, Tom McQuillan,
Amardeep Sian
warmer world. Photography prize How to make molecules
8 Earliest animal for monkeys. Rabbit virus hits at the touch of a button
New Scientist Live
Tel +44 (0)20 7611 1206
Unusual fossil reveals hares? UK to put folic acid in flour 42 Memories of my father
Email live@newscientist.com surprising origins As Stephen Hawking’s final book
Events director Adrian Newton
Creative director Valerie Jamieson
6 NEWS & TECHNOLOGY is published, his daughter Lucy
Sales director Jacqui McCarron 30 The power of fasting Smacking linked to teen violence. reflects on his legacy. Plus an
Exhibition sales manager Charles Mostyn
Event manager Henry Gomm
Why an empty plate may hold Placental stem cells help hips heal. exclusive extract from the book
Conference producer Natalie Gorohova the secret to a longer life Electric chewing gum keeps its and a review
Marketing executive Sasha Marks
flavour. Space rocks could seed life
US Newsstand 42 Lucy Hawking through the galaxy. Earliest ever
Tel +1 212 237 7987
On her father’s extraordinary animal fossil. Mysterious cosmic
Culture
Distributed by Time/Warner Retail,
Sales and Marketing, 260 Cherry Hill Road, legacy radio burst near Earth. Hospital 46 Red sky at night A deeply
Parsippany, NJ 07054 of the future. Moons can have realised novel from Kim Stanley
Syndication Plus 400-tonne fungus (13). moons. Mice with two biological Robinson peeks into our possible
Tribune Content Agency Moonmoons (3 and 10). mothers. 400-tonne fungus. future on the moon. PLUS: This
Tel 1 800 637 4082
Email tca-articlesales@tribpub.com Backwards chemistry (38) A laser that shouts. Forensics gets week’s cultural picks
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constipation. We remember 5000 26 APERTURE
Chesterfield MO 63006-9953 faces. Bees fall silent in eclipse. The world’s most extraordinary
AI’s weird limbs. Sneaky T. rex freshwater environments
52 LETTERS
For mammals, matriarchy
Analysis is second nature
22 INSIGHT Why trying to end all 55 OLD SCIENTIST
suicide could be a bad idea 50 years ago
24 COMMENT More help needed 56 FEEDBACK
for those who lose a pregnancy. Goats with a strange thirst
Medical cannabis in limbo 57 THE LAST WORD
25 ANALYSIS Crisis in space leaves Waxing miracle
the ISS inaccessible

20 October 2018 | NewScientist | 1


LEADERS

Editorial
Editor Emily Wilson
Managing editor Rowan Hooper
Art editor Craig Mackie

News
News editor Penny Sarchet
Editors Jacob Aron, Timothy Revell
Reporters (UK) Jessica Hamzelou
Michael Le Page, Clare Wilson, Sam Wong
(US) Leah Crane, Chelsea Whyte
(Aus) Alice Klein

Features

BARANOZDEMIR/GETTY
Chief features editor Richard Webb
Editors Catherine de Lange, Gilead Amit,
Julia Brown, Daniel Cossins, Kate Douglas,
Alison George, Joshua Howgego,
Tiffany O’Callaghan
Feature writer Graham Lawton

Culture and Community


Editors Liz Else, Mike Holderness, Simon Ings,
Frank Swain

Subeditors
Chief subeditor Eleanor Parsons
Patients before tech
Tom Campbell, Chris Simms, Jon White
We must ensure that data-driven medicine puts people first
Design
Kathryn Brazier, Joe Hetzel,
Dave Johnston, Ryan Wills ADVANCES in technology have For example, people who to imagine that a face-recognition
Picture desk done wonders for keeping us signed up to DNA ancestry system designed to identify
Chief picture editor Adam Goff alive and healthy – think where services probably never expected hospital visitors could one day
Kirstin Kidd, David Stock
we would be without the likes of their genetic data to be put to be redeployed to search for signs
Production
MRI machines, heart monitors work solving murders. Now, of depression.
Alan Blagrove, Anne Marie Conlon,
Melanie Green or ventilators. So it is heartening thanks to the rapid pace of genetic Although medical data is
Contact us to see that Great Ormond Street technology, police are using it generally subject to strict
newscientist.com/contact Hospital in London is now to do just that (see page 14). safeguards, it is not clear whether
General & media enquiries experimenting with how the Even if most people would data that later becomes medically
enquiries@newscientist.com
latest advances in artificial be happy to assist with such useful can be equally protected.
US
210 Broadway #201 intelligence, robots and face enquiries, the benefits of other After all, you never know what
Cambridge, MA 02139 recognition might aid patient reuses of data are thornier still. might come in handy down the
Tel +1 617 283 3213
care (see page 10). Last week, it was revealed that line. Good healthcare relies
UK
25 Bedford Street, London, WC2E 9ES Unlike medical tech of old, Amazon has patented the ability not just on the latest advances,
Tel +44 (0)20 7611 1200 this latest generation heavily of its Alexa voice assistant to but also on trust. In striving for
AUSTRALIA relies on the use of data. And as detect when you are ill, such as innovation, medical practitioners
PO Box 2315, Strawberry Hills, NSW 2012
we are increasingly learning, data by listening out for coughs and must do their best to protect
collected for one reason often sniffles, then offer to buy cough their patients – both now and
ends up being used for another. drops. In the same vein, it is easy for the future. ■

makes light of a serious field


The joy of moonmoons of study. But given that terms
such as super-Earth, twotino and
LAST week, New Scientist sent childlike simplicity makes it a cubewano are all an accepted
© 2018 New Scientist Ltd, England.
certain corners of the internet pleasure to say, and thousands part of the literature, moonmoon
New Scientist ISSN 0262 4079 is published
weekly except for the last week in December into rapturous delight by of readers were quickly firing off doesn’t seem a huge departure.
by New Scientist Ltd, England.
publishing a story about the their own reactions. As it happens, Ultimately, it remains to be
New Scientist (Online) ISSN 2059 5387
New Scientist Limited, 387 Park Avenue potential for moons to have “Moon Moon” is the name of a seen whether the word sticks
South, New York, NY 10016 moons of their own (see page 10). five-year-old meme depicting or gives way to more po-faced
Periodicals postage paid at New York,
NY and other mailing offices This included a suggested name a wolf looking stupid, which alternatives such as submoon
Postmaster: Send address changes to for such objects: moonmoons. certainly helped the idea spread. or second-order moon. But to
New Scientist, PO Box 3806, Chesterfield,
MO 63006-9953, USA. The response on social media Some astronomers are lose moonmoon, and the joy
Registered at the Post Office as a newspaper was an immediate outpouring of bemoaning the use of
and printed in USA by Fry Communications
it brings, would seem an
Inc, Mechanicsburg, PA 17055 glee. Something about the word’s moonmoon, suggesting it astronomical shame. ■

20 October 2018 | NewScientist | 3


THIS WEEK

Golden duo
grab prize
A PORTRAIT of two golden
snub-nosed monkeys has won
the 2018 Wildlife Photographer
of the Year competition.
The pair were snapped by
Dutch photographer Marsel van
Oosten in the temperate forest 
of China’s Qinling mountains, the

© MARSEL VAN OOSTEN /WILDLIFE PHOTOGRAPHER OF THE YEAR


only place where this endangered
species lives.
“This image is a symbolic
reminder of the beauty of nature
and how impoverished we are
becoming as nature is diminished,”
says Roz Kidman Cox, a member
of the judging panel.
The photography competition
is produced by the Natural History
Museum in London.

400 micrograms of folic acid.


Apple hits back at Plan to add folic But many don’t take
Concern over
anti-encryption law acid to UK flour supplements. “Many pregnancies hare deaths
are not planned, meaning many
TECH giant Apple has strongly GOVERNMENT ministers are backing women will not have taken folic BROWN hares are turning up dead
criticised a proposed Australian a plan to fortify flour with folic acid acid around the time of conception across the UK, leading to fears that
law that would force companies to in the UK, according to The Guardian. and very early in their pregnancy,” the highly infectious rabbit disease
provide access to encrypted data. The move is intended to help says Clare Livingstone from the myxomatosis has jumped species.
“Criminals and terrorists… may reduce birth defects that affect the Royal College of Midwives. Myxomatosis, caused by the
start their attacks by accessing just brain and spine. A lack of folic acid Flour is already fortified with myxoma virus, was introduced to
one person’s smartphone,” said can lead to problems with neural tube vitamins and minerals in more rabbits in Australia and Europe in the
Apple in a letter to the Australian development, resulting in conditions than 80 countries, including the 1950s to reduce their numbers. The
government. “In the face of these such as spina bifida and anencephaly. US, Canada and Australia. When disease tore through populations,
threats, this is no time to weaken Pregnant women and those trying fortification was introduced in killing 99 per cent of rabbits in the UK.
encryption.” to conceive are currently encouraged Canada in the 1990s, a marked Numbers bounced back after rabbits
The proposed bill’s public hearing to take a daily supplement of decrease in birth defects was seen. developed some resistance, but the
is on 19 October, but Australia is not disease is still prevalent.
the first to attempt a clampdown Now the University of East Anglia
on encryption. Law enforcement and the Suffolk and Norfolk wildlife
agencies and politicians around the trusts are warning that a mutated
world have long been calling for such form of the virus may be infecting
measures, claiming it is essential to hares. There have been reports
fight crime and terrorism. The UK’s before of the disease seeming to
prime minister, Theresa May, has affect hares, but now a large number
repeatedly pressed the need for a of dead hares have been found over
ban on encryption. a short period of time in the UK – in
Computer scientists say there is one case six in a single field.
MASKOT/PLAINPICTURE

no way to create “back doors” for law If the disease were to hit hares as
enforcement without making devices hard as it did rabbits, the effect could
more vulnerable to hackers, such as be devastating. UK hare populations
those who break into systems and are already thought to have declined
demand a ransom to restore them. by 80 per cent over the past century.

4 | NewScientist | 20 October 2018


For new stories every day, visit newscientist.com/news

Time to adapt to a warming world


Climate change is hitting faster than expected, says Michael Le Page

IT IS not enough to try to limit


further global warming – we must
also do far more to ensure we
survive it. That’s the message
from a coalition of global figures,
including former UN head Ban
Ki-moon and billionaire Bill Gates.
They are part of the Global
Commission on Adaptation
launched this week, which says
that the impact of global warming
is being felt much sooner and
more powerfully than expected.
To keep reducing global poverty
and maintain economic growth,
JONAS BENDIKSEN/MAGNUM

it says societies must do much


more, much faster, to adapt.
“Adaptation action is not only
the right action, it is the smart
thing. We need to make this
case more aggressively. The
costs of adapting are less than have switched to raising ducks conclusion: we have to mitigate Growing flood risks are one impact
the cost of business as usual. instead of chickens. In a flood, and adapt at the same time.” of the rise in global temperature
And the benefits many times chickens drown but ducks swim. The launch of such a big
larger,” says Ban, who, with Gates, Bangladesh has also succeeded adaptation initiative just a week The commissioners also say
in greatly reducing deaths from after a major UN report on what we can combine adaptation with
“We are the first generation cyclones by improving warning it would take to limit warming to efforts to limit climate change.
that has to live with systems and building shelters. In 1.5°C might be seen by some as an For instance, solar panels keep
the consequences of 1970, half a million people died admission of defeat. But scientists homes supplied with electricity
climate change” in one such storm; in 2007, fewer have always made it clear that we if a disaster damages power lines.
than 5000 perished in a cyclone. need to adapt even if warming is While the commission paints
is one of 28 commissioners Adaptation is especially crucial limited to 1.5°C or 2°C by 2100. a rosy picture of the benefits of
heading the new initiative. for the poorest, because they are Based on current policies we are adaptation, in reality there will
Climate adaptation is not hit hardest. Climate change may heading for more than 3°C. be hard choices, such as whether
just about special projects, says plunge around 100 million people to retreat from low-lying coastal
Kristalina Georgieva, CEO of the back into extreme poverty by areas or build flood defences.
World Bank and another of the 2030. “The urgency around
Not defeated This will be true even for wealthy
commissioners. Everyone should adaptation cannot be overstated,” “For quite some time there has cities such as New York.
think about resilience to climate says Patrick Verkooijen, CEO of been a sense that if we opt to “Some places, like lower
change when making decisions: the Global Centre on Adaptation adapt, that means we’re accepting Manhattan, will clearly be
from governments and business initiative. He will help to run the defeat in the fight against climate defended with walls and other
leaders to the general public, for new commission. change,” says Georgieva. “But the structures. But will billions be
instance when buying a home. All those involved in the call truth here is that we already are spent to protect, say, Howard
“A very significant opportunity for adaptation still stress the experiencing the consequences Beach, a low-lying neighbourhood
for adaptation comes from need to cut emissions to limit, of the changing climate. It’s not in Queens? I don’t think so,” says
mainstreaming resilience in the or mitigate, further warming. defeat, it’s reality that we face.” Jeff Goodell, author of The Water
normal investments we make,” “We are the last generation that That means giving equal Will Come. “In most places, retreat
says Georgieva. “It doesn’t have to can mitigate climate change priority to adaptation. Half of is inevitable. And it will be driven
be a more expensive investment, effectively. We are the first the money the World Bank lends by simple economics. The hard
it has to be done with risk in generation that has to live with for climate-related projects – truth is, adaptation to quickly
mind.” For example, she describes its consequences,” says Georgieva. $20.5 billion in the past year – now rising seas is a luxury that few
how some farmers in Bangladesh “That leads to a very obvious goes on adaptation, she says. can afford.” ■

20 October 2018 | NewScientist | 5


NEWS & TECHNOLOGY

12 per cent where there are means one causes the second.
Smacking linked to none (BMJ Open, DOI: 10.1136/
bmjopen-2018-021616 ).
It could be that the second
causes the first. For instance,

teenage violence This suggests “bans not only


keep children safe from adults,
but also from their peers”, says
teenagers who get into lots of
fights might grow up to be
tougher disciplinarians.
Alana Ryan of the UK’s National Or perhaps smacking and
Clare Wilson schools, but is legal for parents, Society for the Prevention of teenage fights are both affected
as is currently the case in the UK. Cruelty to Children, which has by a third factor, such as broader
A GLOBAL survey has found that The analysis found that long campaigned for a ban on societal attitudes. For centuries,
teenagers get into more fights in 13-year-olds from places with full smacking in the home. there has been a slow decline in
countries where it is legal to spank smacking bans were less likely to But Catey Bunce of the UK Royal violence across many aspects of
children, prompting campaigners get into frequent fights than those Statistical Society says this makes society, according to an idea
to renew calls to make corporal from nations where it is allowed the mistake of assuming that a popularised by Steven Pinker of
punishment illegal. everywhere. In boys, who fought correlation between two things Harvard University. Any falls in
Smacking children used to be the most, the rates for frequent smacking and teenage fighting
commonplace in parenting, but fighting were 8.5 per cent where Teenagers seem to fight more could be two manifestations of
a growing list of countries have there are full smacking bans and where spanking is permitted– this trend, without one directly
banned it, including Sweden, causing the other.
Germany and New Zealand. The “As a parent, I would not smack
practice will soon become illegal my children, so it is tempting to
in Scotland, and there are calls for believe if they were exposed to
the same to happen throughout it they would become more
the rest of the UK. aggressive,” says Bunce. “But
Supporters of smacking say that you need to be wary of jumping
it can be necessary for discipline, from correlation to causation.”
but campaigners say that it makes Another caveat to the latest
parental child abuse more likely, findings is that there was just
and promotes violence more a small difference in frequent
generally. To see if childhood fighting between countries
smacking might later affect with full bans and partial bans.
teenage behaviour, Frank Elgar In boys, the rates were 8.5 per
of McGill University in Montreal, cent versus 10 per cent, a gap too
Canada, and his colleagues small to be found statistically
analysed child survey data from meaningful by this analysis.
88 countries. But Elgar says other evidence
These countries were each shows that smacking makes
classed in one of three ways: children more violent. “Being hit
no smacking bans, full smacking or spanked or slapped does affect
P.WEI/GETTY

bans, or partial smacking bans, how kids react in their own social
where smacking isn’t allowed in relationships,” he says. ■

Stem cells from potential to turn into different kinds


of tissue and release chemicals that
hip muscles than those in the
placebo group, as measured by
The improvements seen in strength
suggest that the cells would reduce
placentas could promote healing.
To see how the cells affect muscle
an exercise machine (Journal of
Cachexia, Sarcopenia and Muscle,
limping in people having second or
third joint replacements, where the
help fix muscles repair, Tobias Winkler of Charité – doi.org/cvsw). All of the people in muscle starts off in worse condition,
Berlin University of Medicine in the experiment – even those in the says Winkler.
STEM cells taken from placentas Germany and his colleagues tested placebo group – were limp-free by Dennis McGonagle at the University
have healing properties that can two different doses of the cells in the time they were tested at six of Leeds, UK, says animal studies
help people recover from having 20 people having hip replacements. months, probably because everyone show that stem cells are often killed
their hip joint replaced. During the operation, surgeons have was having their first hip surgery, by the recipient’s immune system
Placentas are normally thrown to cut into muscle tissue around the says Winkler. when they are injected into the body.
away after childbirth, but now joint, which can leave people limping But mesenchymal stem cells seem to
Israeli company Pluristem has taken for several months, particularly if it “Six months after the release tiny packages of beneficial
discarded placentas and developed isn’t their first hip replacement. operation, people who compounds before this happens.
a batch of mesenchymal stem cells Six months after surgery, people got stem cell doses had “They are full of growth factors and
from them. These cells have the who got a dose of cells had stronger stronger hip muscles” other goodies,” he says. Clare Wilson ■

6 | NewScientist | 20 October 2018


For daily news stories, visit newscientist.com/news

Hi-tech chewing Panspermia is the idea that


asteroids seed life through space
gum will never microbes to take shelter from the
lose its flavour punishing space environment in
the interior of the rock.
CHEWING gum that zaps your tongue “It’s a very dangerous ride, but
with electricity keeps the flavour you can think of the microbes as
going forever. tiny astronauts sitting in a natural
The pain-free device is called spacecraft,” says Loeb. “I would
“unlimited electric gum”. It uses the actually be thrilled to be a microbe
piezoelectric effect – a phenomenon sitting in a rock that makes it
where some materials produce across the Milky Way.”
electric charge when squeezed. When Once one of these life-laden
the “gum” is chewed, it produces a rocks is captured into orbit
STOCKTREK IMAGES/ALAMY STOCK PHOTO

small current, which tricks the tongue around a new star, it can smash
into experiencing different tastes. into a planet, dropping off its
It currently produces a salty or passengers. The same process on
bitter taste. But the hope is to extend a smaller scale could also spread
that, since other research has shown life to other planets in the system.
that, by varying the pattern and Many Mars rocks have been
strength of electric charge, it is blown off the planet by impacts,
possible to induce all five of the basic ending up on Earth. This has led
tastes our mouths pick up: bitter, some people to speculate that
salty, sour, sweet and umami.
At an event in Japan earlier this Alien life could ride space life on our planet could have
come from Mars. It is even
year, 80 people tried the gum. Almost possible, if unlikely, that life on
everyone reported experiencing salty rocks to travel the stars Earth began with interstellar
or bitter tastes. Some said chewing it microbes, says Loeb.
was a bit like chewing niboshi, which LIFE finds a way – perhaps even stuck on such interstellar However, Ed Turner at
are small dried infant sardines used in across the stars. It may really be projectiles would be to survive. Princeton University says the
snacks and seasonings in Japan. possible for organisms to travel “It’s like billiards,” says team may have overestimated
The gum consists of a piezoelectric all over the galaxy by hitching Ginsburg. “You hit the cue the likelihood that these captured
element and electrodes, wrapped a ride on a fast-moving rock in ball and it hits the other balls, objects carry life. And many of
in a thin plastic film. It is a couple of a phenomenon called galactic and beside just transferring these objects would not be
centimetres wide, like a standard panspermia. In this way, just a momentum it also spreads life, chipped from larger, habitable
stick of gum. Unlike real chewing gum, few inhabited worlds could spread and then life spreads across the planetary bodies, so if they have
the electric version will continue to life throughout the Milky Way. whole table, which is the galaxy.” life, it must have evolved there
stimulate the taste buds for as long In October 2017, astronomers on its own.
as it is chewed – and it won’t break spotted the first interstellar “I would actually be thrilled “Only a tiny fraction of the
down into a sticky glob. object we have ever seen come to be a microbe sitting objects that would be captured
Naoshi Ooba at Meiji University in through our solar system, called in a rock that makes it would plausibly carry life,” he
Japan and his colleagues created the ‘Oumuamua. That was the first across the Milky Way” says. “If that somehow were not
device, and demonstrated it at the concrete proof that rocks can be the case and a lot of them carried
ACM Symposium on User Interface tossed out of orbit from distant The team has found that up to life, then life is very common
Software and Technology in Berlin, stellar systems and make it intact 100 million life-bearing objects and you probably don’t need
Germany, this week. to our solar system. with a radius of 200 kilometres – panspermia anyway.”
This is the latest in a line of Of course, it is not enough for about half the size of Saturn’s Our space-faring descendants
taste-related gadgets devised by a space rock to travel between moon Enceladus – could have may even be able to test this idea.
researchers. These include a digital the stars. In order to transfer life, been captured in stellar systems If life in different places around
lollipop that people can lick to get it must also be captured by a around the Milky Way. the galaxy is varied and diverse,
different tastes, and a virtual star’s gravity and eventually Even about 1000 Earth-sized that would be an indication that
lemonade that uses electrodes to trick smash into a planet. objects could have been collared it arose independently on each
someone into thinking that water is Now, Idan Ginsburg, Manasvi in this way, they say (arxiv.org/ world. However, if there are
actually the fruit-flavoured drink. Lingam and Avi Loeb at Harvard abs/1810.04307v1). groups of stellar systems with
Ooba and his team plan to add other University have calculated just Smaller objects are much similar life on their planets, this
flavours to the electric gum, and want how often these banished rocks more likely to make the journey could mean that microbes really
to eventually create a product that might be captured by a new stellar between stars, but the smaller are travelling between the stars,
people can buy. Timothy Revell ■ system, and how likely any life they get, the harder it is for says Loeb. Clare Wilson ■

20 October 2018 | NewScientist | 7


NEWS & TECHNOLOGY

Earliest signs of
animal life found
Chelsea Whyte Siberia and India that date to
between 635 and 660 million
SPONGES were probably one of years ago.
the earliest animal groups to They found plenty of a sterane
evolve, but it has proved hard called 26-methylstigmastane
to work out exactly when in that, as far as we know, is only
geological time they appeared. produced by demosponges.
Now, an analysis of ancient In previous work, Love
rocks and oils has turned up traces had found another possible
of steroids made by early sponges sponge biomarker, called
that indicate they may have been 24-isopropylcholestane (24-ipc),
populating the ancient sea floor in the same rocks. But some JOHNANDERSONPHOTO/GETTY

at least 120 million years earlier modern algae make a similar


than we thought. compound, so the ancient 24-ipc
“If animals first appeared in might not have come from
a predominantly bacterial or sponges. Love says the evidence
microbial world, they would for sponges in the rocks is now
need to harness microbes and live clearer (Nature Ecology &
symbiotically with them,” says Evolution, doi.org/cvsx). There is a big puzzle over other living organisms that make
Gordon Love at the University of But the finding hints at a big when sponges evolved the specific molecules that Love’s
California, Riverside. That may puzzle. Sponges have “skeletons” team found, there is a chance they
be why sponges produce a vast made of silicon fibres called discovered them yet. But Botting are – or once were – out there.
array of sterols: steroids with spicules that give structure to says there are many people Love says there is another
antibacterial properties that their holey bodies. We don’t see hunting for them – and they possibility: the very first sponges
could let them harbour microbes fossil evidence of spicules until have yet to find any. may have lacked silicon spicules
without harm. about 540 million years ago, at So perhaps some other that would have been preserved
The earliest sponges belong the dawn of the Cambrian period. organism was making these as microfossils. If so, this would
to a class called demosponges, “If the biomarkers here are a compounds 660 million years explain why there are molecular
which produce sterols that genuine sign of sponges, then ago, having evolved the same signs that sponges were present
can be preserved in rocks as we’ve got a huge problem with the ability independently of sponges. 660 million years ago even
characteristic sterane molecules. fossil record,” says Joe Botting at Although we know that, today, though there is no microfossil
Love and his team went hunting the National Museum Wales, UK. sponges produce more sterols evidence. In other words, we
for these “molecular fossils” in It could be that older spicules than all other complex life forms could be looking for fossils that
rock and oil samples from Oman, are out there and we just haven’t combined, and we haven’t found don’t exist. ■

Cosmic radio Most detected bursts have been


from billions of light years away,
(arxiv.org/abs/1810.04354v1).
The galaxy is of a comparable size
previous suggestions that such
emissions are required for FRBs.
signal spotted making them hard to study. But Ryan
Shannon at Swinburne University
and has a similar star formation rate
and oxygen abundance to the only
Mahony and her team are now
focusing their telescopes on ESO
close to Earth of Technology in Australia and his other galaxy in which an FRB has been 601-G036 to confirm that it does
colleagues recently found one that pinpointed, which lies 2.4 billion light produce FRBs. If they spot another,
A STRANGE flash of radio waves occurred unusually close to Earth. years away from us in the constellation they may be able to pinpoint which
detected from space has been traced Dubbed FRB 171020, it was spotted Auriga. However, ESO 601-G036 part of the galaxy it comes from.
to a galaxy that lies relatively nearby. by the Australian Square Kilometre doesn’t emit the same continuous “Then we might actually be able to
Fast radio bursts (FRBs) are blasts Array Pathfinder telescope. Elizabeth stream of low-level radio emissions solve the mystery of what causes
of radio waves that last for only a few Mahony at Australia’s national science as the Auriga galaxy, contradicting these fast radio bursts,” she says.
milliseconds yet can contain as much institute, CSIRO, and her colleagues, Some people believe they are alien
energy as our sun puts out in decades. including Shannon, have now “The team’s telescopes are messages, but Mahony says they
More than 50 have been spotted since determined that it probably came trained on the galaxy to are more likely to be the products of
they were first discovered in 2007, but from ESO 601-G036, a galaxy that is try to pinpoint the source astrophysical events, like the creation
we still don’t know what causes them. 120 million light years from Earth of the fast radio bursts” of neutron stars. Alice Klein ■

8 | NewScientist | 20 October 2018


WHAT IF TIME STARTED
FLOWING BACKWARDS?

WHAT
IF THE
RUSSIANS
GOT TO
THE MOON
FIRST?

WHAT IF DINOSAURS
STILL RULED THE EARTH?
AVAILABLE NOW
newscientist.com/books
NEWS & TECHNOLOGY

Moons of a
moon are called
moonmoons
STARS are orbited by planets, which
are orbited by moons, but what
comes next? More moons, according
to a new analysis.
A moon of a moon has no formal
name, perhaps because we have
never spotted one, but both submoon
and moonmoon have been suggested.
Such an object would have to be close
enough to its host moon to remain
gravitationally bound to the moon
STANTON MEDIA

instead of the larger planet, but not


so close that the moon would rip it
apart or pull it out of orbit.
Juna Kollmeier at the Carnegie
Robots, such as Sota, can assist

Futuristic hospital
Observatories in California and
with health checks Sean Raymond at the University of
Bordeaux, France, have calculated

unit is launched By streamlining the simple


actions that are performed in
hospitals thousands of times a
that four moons in our solar system
could theoretically have submoons:
Earth’s moon, Jupiter’s moon Callisto
day, such as registering patients and Saturn’s moons Titan and Iapetus
Douglas Heaven engineers can interact with and tracking people’s movements, (arxiv.org/abs/1810.03304).
patients, doctors and nurses – it hopes to free up more staff time These moons are all relatively large
IN THE five steps from the door sometimes role playing actual for patient care. and far from their planets, so there is a
to the reception desk, my photo scenarios – to find out what new Since GOSH is a children’s small area in orbit around each where
has been taken, my face saved in tech can and can’t do before it hospital, there will be a focus on the planet’s gravity might not steal
the system and an ID number is rolled out in clinical settings how tech can improve the care of a moonmoon away. But even if these
assigned. For the rest of my time across the NHS. younger people. Several projects moons could host a moonmoon, it
at this new high-tech unit in Great “It’s a digital sandpit,” says are under way, including a blue would be difficult to get one in the
Ormond Street Hospital (GOSH) Noel Hurley at Arm. “It lets whale in the main entrance right place, says Raymond.
in London, I am followed by an AI. us experiment and play and and rabbits hopping about the “Something has to kick a rock into
Video screens that will be build and break things in a safe wards – visible only to those with orbit at the right speed that it would
visible only to staff show my environment.” an augmented reality app. go into orbit around a moon, and not
head in a red box, annotated with Arm’s chips power most of One project already up and the planet or the star,” he says. And
a score showing how confident the world’s smartphones, but it running is Project Fizzyo, which if that moon moved around over the
the computer is that I am who it is also involved in healthcare, helps children with cystic fibrosis course of its evolution, as our moon
thinks I am. providing the hardware for many put up with their physiotherapy has, it is unlikely the submoon would
Tracking systems like this are by making the physio device stick around.
just one of the technologies being “Projects under way include they have to squeeze into a game There has also been speculation
tested at GOSH’s DRIVE (Digital, a blue whale that is visible controller. The better you get at about whether a moonmoon could
Research, Informatics and Virtual only to those with an doing physio, the better you are orbit a distant moon that may be
Environments) unit, which augmented reality app” at the game, says Neil Sebire, the first ever spotted outside our
opened last week. The unit is managing director at DRIVE. solar system, around a planet called
a collaboration between the medical devices. The company Hospital staff are also asking Kepler-1625b. That exomoon, if it
UK’s National Health Service, now wants to embed AI in those young patients what they would exists, is probably a gas giant, orbiting
University College London and devices so they can make quick, like in a hospital. “Most of them an even larger gas giant.
several tech companies, including automated decisions. want robots,” says Sebire. Two “This system where you’ve got a
Microsoft, Samsung and UK Medical AI has made great robots are now being developed giant planet and a Neptune-sized
chip-maker Arm. strides in diagnosing certain that can tell stories inspired by moon that’s kind of far away from the
Although the unit is part of conditions, such as cancer and nearby objects. “Children are not planet is sort of the best-case scenario
GOSH, it doesn’t provide clinical eye disease. But Arm is more limited by what they think tech for a moonmoon,” says Raymond.
care. Instead, it is a place where interested in the smaller tasks. can do,” he says. ■ Leah Crane ■

10 | NewScientist | 20 October 2018


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Humanity will need the
equivalent of 2 Earths to People lying down
support itself by 2030. solve anagrams in
10% less time
than people
standing up.

About 6 in
100 babies
(mostly boys)
are born with an
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with two mothers. They achieved mothers, succeeding 27 times.


Mice pups born to this by deleting a piece of DNA in
one of the female genomes to try
What’s more, Li’s team also
created 12 mice with two fathers

same-sex parents to mimic normal imprinting. But


500 attempts produced just two
mice that survived to adulthood.
from 500 attempts, by deleting
seven pieces of DNA to try to
mimic imprinting. However,
Li and his team have greatly none survived to adulthood
Michael Le Page Even if you somehow combined raised the success rate by deleting (Cell Stem Cell, doi.org/cvrw).
the genomes of two females – three bits of DNA to better mimic Li’s work reveals more about
WE ARE a small step closer to the or two males – in an egg and the normal imprinting required which imprinted genes are crucial
day when two women or two men kick-started development, the for embryo development. for normal development in mice.
could have biological children of imprinting would not be normal They made a total of 200 attempts However, it is not clear if the
their own, thanks to improved and the resulting embryo will die. at creating a mouse with two results apply to other mammals
methods for creating mice with But in 2004, a group in Japan such as humans. The team will
same-sex parents. But the work managed to create Kaguya the One of the newborn mice test this by trying to create
also shows that there is a huge mouse, the first ever mammal created by researchers in China monkeys with two mothers.
amount still to do before this Before we could even think
could be attempted in humans. of trying to create human babies
“It is [right] to emphasise the with same-sex parents, we would
risks, and the importance of need a way of mimicking imprints
safety, before any human without resorting to genetic
experiment is involved,” says modification, not least because
Wei Li at the Chinese Academy permanently deleting genes
of Sciences in Beijing, who led would have harmful effects in
the latest research. “But we think later generations.
our work does take it closer.” But that might just be possible.
The biggest obstacle to creating Several groups are modifying
babies from same-sex parents is CRISPR gene-editing tools to allow
a genetic phenomenon called them to add or remove epigenetic
imprinting. This means certain markers without changing the
genes in the sperm genome are underlying DNA sequence.
switched off by adding epigenetic Even if that sort of approach
markers to the DNA. These are works, huge safety questions
molecules that affect gene activity remain. “Faulty imprints do give
but don’t change the underlying rise to human diseases,” says
DNA sequence. Imprinting also Azim Surani at the University of
occurs in eggs, but with different Cambridge, who discovered the
genes turned off. imprinting phenomenon in 1984.
Normal imprinting in sperm Any manipulation of imprints
LEYUN WANG

and eggs is crucial for embryo could therefore have serious


development in mammals. consequences, he says. ■

Massive fungus Armillaria gallica in the late 1980s,


while studying other fungi that
allowing them to get a better sense of
its shape below ground. The fungus
limit is the end of the last ice age,
about 11,000 years ago, because
is older than were killing red pines on a Michigan
plantation. It spanned at least 0.37
weighs at least 400,000 kg, four
times larger than the initial estimate.
that’s when Michigan’s forests began
to grow. “It may go all the way back to
Christianity square kilometres. At the time, they The fungus grew from a single post-glaciation, when the forest was
estimated it was at least 1500 years individual, so its greater size implies re-establishing on that site,” says
A HUGE fungus that is one of the old and weighed at least 100,000 kg. it is also older than thought. “We’re Anderson (bioRxiv, doi.org/cvq6).
largest living things on the planet Back then, the fungus was a now saying 2500 years based on our The team was also able to estimate
turns out to be both bigger and older contender for the largest living estimates of growth rate, and that’s how many genetic mutations the
than thought. It may have been organism, but bigger fungi have a lower bound,” says Anderson. fungus has accumulated over its life,
spreading through the soil of Michigan since been found. It could be much older. The upper a rate Anderson says is “almost
since the end of the last ice age and Anderson and his colleagues have impossibly low”. It’s not clear how
weighs at least 400,000 kilograms. now revisited the fungus, which had “We’re now saying it’s 2500 the fungus manages this: it may be
James B. Anderson at the University been left to its own devices since years old based on our unusually good at repairing DNA
of Toronto in Canada and his the early 1990s. They collected estimates of growth rate, damage, or have a purposely slow rate
colleagues found the honey fungus 245 samples, far more than before, and that’s a lower bound” of cell division. Michael Marshall ■

20 October 2018 | NewScientist | 13


NEWS & TECHNOLOGY

Laser weapon Most of a sample’s genetic data is


ignored in the search for a match
shouts, then MyHeritage. “Currently, they have
burns people this dilemma: should we run a
CODIS set on our DNA or use the
THE US Marines are developing a more sophisticated techniques?”
laser weapon that can transmit voice Now Noah Rosenberg at
messages at long range – or be turned Stanford University in California
up to deafen or cause painful burns. and his colleagues have developed
The Scalable Compact Ultra-short a computational model that
Pulse Laser System (SCUPLS) will be a makes it easier to link people
non-lethal weapon for crowd control, in CODIS to those in genealogy
according to US Navy documents. databases.
The weapon builds on previous The model relies on the fact
prototypes developed by the that some of the single-letter
Pentagon. An igniter laser fires an variations recorded by ancestry
intense pulse lasting just a few databases are gathered from
JASON BUTCHER/GETTY

million-billionths of a second. This roughly the same part of the


creates a ball of plasma, which can be genome from which the longer
created in mid-air or on the surface stretches of DNA recorded in
of a target. A detonator laser then CODIS come from. This gives
explodes the plasma ball, resulting potential overlaps.
in a flash and a bang. Rosenberg and his team tested
the model with data from 872
Crime scene DNA
At the lowest power setting, a
rapid series of flash-bangs will be people. They found that they
modulated to carry robotic speech, could identify about 35 per cent of
conveying instructions over distances
of up to 100 metres.
At higher levels, it will produce
gets more revealing sibling pairs by comparing CODIS-
like DNA from one member of the
pair with ancestry database-like
flash-bangs as loud as the inside of DNA from the other member of
a jet engine and dazzlingly bright. Chelsea Whyte The US national DNA database the pair (Cell, doi.org/gfb8w6).
When aimed at a person, SCUPLS used by police and the FBI – called “This could expand the
will painfully vaporise the outer POLICING power may be about to CODIS – doesn’t store whole DNA number of cold cases that are
layer of skin. The weapon is likely get much stronger, thanks to an sequence data. Instead, it focuses solvable,” says Natalie Ram at
to be mounted on a small vehicle. advance in genetic analysis. A new on up to 20 specific stretches of the University of Baltimore,
Previous weapons have been technique can link the limited repetitive DNA code that are Maryland. She says it also raises
limited by the strength of available DNA information held in forensic relatively easy to sequence. These questions about how private our
lasers. “They cannot, to-date, provide databases to the rich DNA libraries regions vary between individuals, genetic information is.
the full laser performance necessary held by family tree-building so can help identify people. The CODIS system was designed
to deliver all three of the desired websites – which raises questions Consumer genetic databases to be minimally informative, so
non-lethal effects,” the Pentagon about genetic privacy. store different data: single-letter that it can’t reveal information
told New Scientist. The SCUPLS Earlier this year, police variations in DNA across beyond identity, says Rosenberg.
project will work to increase both identified someone they But the DNA data in genealogy
the power per pulse and the number suspected was the Golden State “This could expand the websites can reveal physical or
of pulses per second. Killer – a serial killer active in number of cold cases that medical characteristics, so the
SCUPLS could be more adaptable California decades ago – with are solvable, but it also ability to link between the
than existing crowd-control weapons. the help of an ancestry database raises privacy questions” systems might make it possible
For example, an individual can be used by people looking to trace to find out more about a suspect
ordered to stop or put down a weapon. their family history. hundreds of thousands of sites from their DNA.
If they fail to comply, SCUPLS could Since the arrest in April, in the genome. Because they However, at least for the
apply increasingly unpleasant effects genealogy databases – which carry more information, these moment, the number of
until the individual complies. allow consumers to upload their commercial databases can more matches between CODIS and
But it is not clear how safety will DNA sequences – have been used accurately pin down a person’s consumer sites is limited. This
be ensured. “Dosage will be decisive to crack several other cold cases. relationship to others. is because CODIS is dominated
for avoiding permanent injury,” says Police are turning to consumer “When police have DNA by DNA samples from minority
Jürgen Altmann at Dortmund genetics databases because evidence, usually it’s very minute groups, while genealogy sites are
University of Technology in Germany. the forensic ones hold only quantities,” says Yaniv Erlich of mostly used by white people of
David Hambling ■ limited genetic information. genetic ancestry company European descent. ■

14 | NewScientist | 20 October 2018


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IN BRIEF
BJARKI REYR/ALAMY STOCK PHOTO

Pills jiggle to get


your bowels going
CAPSULES that vibrate in the
gut can ease constipation.
The usual advice for those
with the condition – to eat
more fibre, exercise and take
laxatives – doesn’t always work.
To address this, Israeli firm
Vibrant has developed capsules
the size of fish oil supplements
that vibrate in the large intestine
to stimulate contractions that
move digestive products along.
Satish Rao at Augusta
University in Georgia and his
colleagues tested the capsules in
two clinical trials involving 245
people with chronic constipation.
Participants took capsules for
eight weeks. Half had versions set
to vibrate in the large intestine.
The others had non-vibrating
placebos. The vibrating capsule
group had twice as many bowel
movements per week. Rao
presented the results at the annual
Our memories are packed On average, participants listed 40 people in the first
5 minutes of the exercise and 21 in the final 5 minutes. meeting of the American College
with thousands of mugshots From these rates,the team calculated that a typical of Gastroenterology last week.
participant would have listed 549 people if they were
YOU can probably recognise a lot more faces than you given unlimited time.
might think, typically about 5000. Then they tested recognition of famous faces by
Algae could ferry
“It seems to be overkill,” says Rob Jenkins at the showing images of 3441 public figures from the likes of
University of York in the UK. That is because humans film, business, politics and sport. Each participant saw a drugs in your body
lived in groups of around 150 people for most of our different picture of each figure on separate days. If they
evolutionary history, so the usual idea is that it makes said they recognised the celebrity in both pictures, that SOME algae can swim surprisingly
sense for us to recall about this number of faces. person was considered part of their “facial vocabulary”. fast, a talent that may make them
To test this idea, Jenkins and his team asked Participants recognised about 30 per cent of these an ideal drug delivery system.
25 people to spend an hour writing down the people faces. Based on this, Jenkins and his team estimated that Metin Sitti at the Max Planck
they knew personally for whom they could form a clear most people can recall about 5000 faces (Proceedings of Institute for Intelligent Systems
mental image of their face. the Royal Society B, doi.org/cvqb). in Germany and his colleagues
figured out how to attach tiny
magnets to a freshwater alga.
Diet of pregnant mice affects grandpups male offspring created a third. Then they applied a magnetic
Both were found to have a field to control the direction it
IF A female mouse has a fatty diet Daria Peleg-Raibstein at the 7 per cent greater body weight and swam in (Advanced Materials,
just before, during and just after Swiss Federal Institute of a greater preference for alcohol doi.org/gd93zt).
pregnancy, her pups, grandpups Technology in Zurich and her than normal mice. They also had The aim is to load algae with
and great-grandpups have a raised colleagues wondered about the less dopamine, the brain’s signal drugs and steer them to diseased
risk of obesity and addiction. impact on the second and third for pleasure, and more dopamine tissue. At present, a drug must
Animal studies have shown generations. They fed female mice receptors. Both brain changes may be applied to a wider area or the
that such a high-fat diet can lead a high-fat diet for three weeks have increased the amount of entire body, which can cause
to offspring with a less sensitive before they mated, and six weeks food and alcohol the mice needed unpleasant side effects.
reward system: they need more after. The male offspring were bred to feel satisfied (Translational The team is working on ways to
food to feel full and are more with female mice who had been Psychiatry, doi.org/cvqw). It is too ensure immune cells don’t attack
susceptible to becoming obese or fed a normal diet to produce a early to say if this has implications the algae before they reach their
addicted to drugs. second generation, and those for people, says Peleg-Raibstein. destination.

20 October 2018 | NewScientist | 17


IN BRIEF
For new stories every day, visit newscientist.com/news

Eclipse didn’t get AI invents weird limbs to conquer virtual landscape


the bees buzzing WHAT are the best two legs for reaching the exit and not falling artificial intelligence free rein,
acing an obstacle course? For an over. This encouraged it to find high jinxs ensued. When given
BEES suddenly went quiet during AI: one that pulls you forward the best leg designs. no constraints and asked to
the solar eclipse that swept across by flexing at the knee joint, and When the terrain was fairly flat, cross an obstacle-laden course,
North America in August last year. one massive leg pulled behind the AI crossed most quickly with the AI built an extremely tall
A set of 16 monitoring stations for stability like a kangaroo tail. a jaunty, skipping gait performed bipedal creature that simply
recorded them falling silent as David Ha at Google created a on the “knees” of long, skinny fell down to reach the exit.
the moon totally covered the sun. virtual robot with a wide head. legs. This beat walking on the When rewarded for building
Candace Galen at the University It had two legs that it could “feet” of shorter, thicker legs. smaller legs, the AI took that
of Missouri and her colleagues set design itself. He tasked it with When facing a landscape with to an extreme, tottering on tiny
up microphones in stands of flowers crossing a randomly generated pits and obstacles to climb, the legs across a fairly flat surface.
along the path of the eclipse, from virtual landscape within a set AI developed one long, skinny An algorithm like this could
Oregon to Missouri, to listen to bees. time. The artificial intelligence leg that it used to sense obstacles, come up with designs we had
They found that as the moon learned to do this with an and a larger hind leg dragged in never thought of and that
started to move in front of the sun, algorithm that rewarded it with its wake to stabilise itself. outperform ours, wrote Ha
the bees continued buzzing. But points for supporting its head, As is usual when you give (arxiv.org/abs/1810.03779).
in the period around totality, the
sound, created by the bees’ wings

NATURE PHOTOGRAPHERS LTD/ALAMY STOCK PHOTO


as they fly, suddenly dropped off.
Why T. rex wasn’t
“We had expected to see a
reduction in activity, but we such a big noise
thought that it would be gradual
following the loss of light,” says IT IS easy to think Tyrannosaurus
Galen. “We didn’t expect everything rex was so large that the ground
to go along as usual until totality.” shook as it approached. But it
The team recorded sound for seems the dinosaur made less
3 minutes – covering the period of a rumble than expected.
of totality that lasted 40 to 160 Heavy animals produce
seconds depending on the earthquake-like seismic waves
location – and found that only one with every footfall. We know that
bee buzzed during those 3 minutes other animals can detect these.
(Annals of the Entomological Large dinosaurs must have
Society of America, doi.org/cvp9). produced seismic waves too.
It isn’t clear whether the other Ernesto Blanco at the University
bees flew back to their hives, as of the Republic, Uruguay, and his
they do at night, or whether they colleagues decided to investigate.
sheltered in flowers, as they do in They analysed 64 fossil footprints
inclement weather. “All we can say left by large dinosaurs, including
is what they weren’t doing – they herbivores, omnivores and Scat lets rabbit know it’s on the menu
weren’t flying,” says Galen. carnivorous theropods – a group
that includes T. rex. The theropods IF YOU are a rabbit, it is vital to know from the scent of its droppings.
NASA/GETTY

had a more elongated foot. when predators are around. It is The researchers ran an experiment
When they simulated the even more useful to know if they are in the Spanish countryside. One area
seismic wave pattern generated eating your kind, and it seems rabbits was sprayed daily with an extract of
when the various dinosaur feet can do this by detecting the whiff scat of ferrets on a beef-based diet.
hit the ground, they found the of a digested bunny in droppings. Another was sprayed with the scat
waves from theropod feet were The European rabbit is a very odour from ferrets on a rabbit-based
weakest in the walking direction. popular meal for predators – more diet. The third was sprayed with
In other words, theropods had than 30 species eat it, says José water as a control.
a foot shape that would have Guerrero-Casado at the University Guerrero-Casado’s team counted
allowed them to sneak up on of Cordoba in Spain. rabbit droppings on the plots to
their prey, seismically speaking. This rabbit has an impressive gauge how often the animals were
Blanco suggests that elongated ability to smell predators. But visiting to feed. They found fewer
feet may have evolved because Guerrero-Casado and his colleagues droppings in the area sprayed
they gave theropods a hunting wondered if it could also tell if a with rabbit-based scat odour
advantage (Journal of Theoretical predator had already eaten rabbit (Acta Ethologica, doi.org/gd9948).
Biology, doi.org/cvq3).

18 | NewScientist | 20 October 2018


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of new low carbon targets. “We’re trying to it is thorough. “We’ve brought in an external
“BP is
reduce emissions in our own operations, to partner who looks at these activities to check focusing
improve our products to help our customers our figures and make sure they are robust and on carbon
reduce their emissions, and also to create verifiable,” she says.
new low carbon businesses. The Advancing The Advancing Low Carbon programme is emissions
Low Carbon programme is looking to beginning to change BP from the inside by in every
encourage more action in all of these areas,” energising low carbon thinking. “We need to
says Mannion, who has a degree in ecology. think right across the company how we can
aspect of its
For example, BP is one of the top wind encourage and drive low carbon action,” business”
energy producers in the US, generating says Mannion. “To deliver significantly lower
2259 MW of renewable power. That’s emissions, every kind of energy needs to be
enough to power every home in Philadelphia. cleaner and better.” Q
But it’s not just renewable energy sources
she is focusing on. “We know that the world More at: newscientist.com/BP
All change
Nexcel is a reusable and easily replaceable
cell, like a cartridge, that contains all the oil
for an engine along with the oil filter. It’s being
developed to be engineered into cars of the
future. So an oil change will be as simple as
lifting out the cell and replacing it with
another, which takes about 90 seconds.
Because the used oil is contained, all of it
can be recycled.That has significant benefits.
The world produces about 6 billion litres of
used engine oil every year but only about a
quarter is recycled. In fact, about 2 billion litres
is not recovered by licensed waste companies
and so ends up in local waste streams,
where it can be hugely damaging.
Nexcel will allow engine oil to be efficiently
recycled and reused. It also does away with
the need for oil to be stored and sold in single
use plastic containers.
The system can also improve engine
efficiency. One factor that determines this
is the temperature of the engine oil.The oil
becomes less viscous, reducing friction
within the engine, as it heats up.That’s one
reason why hot engines are more efficient.
In contrast, an engine running on cold oil uses
up more fuel and is therefore more wasteful.
When a conventional engine starts from
cold, it has to heat all the oil in the sump –
usually around 5 litres. “That’s a large volume
of oil to be heated before you reach the
optimum temperature,” says Rachel Fort,
a chemist who is a senior formulation
technologist at Nexcel.
But the Nexcel system feeds oil into the
engine in small, precisely controlled amounts
that quickly heat up. So the engine can
operate more efficiently from the start.
In-house testing indicates that this, along
with other lubricant technologies enabled
Above centre: by Nexcel, could translate to a reduction in
Rachel Fort, Nexcel carbon dioxide emissions of 2 grams for every
kilometre driven. “That may not sound like
Above: The Aston much, but every gram is important, “says
Martin Vulcan uses Fort. “Over the lifetime of a vehicle, that
the Nexcel system equates to about a third of the vehicle mass.”
INSIGHT SUICIDE PREVENTION

Inside the plan


to end suicide
Politicians say they want to aim for zero suicide, but that target
might be counterproductive, says Clare Wilson

“ZERO suicide” is the phrase of half of UK suicides. By the end of try to swim to the side.” Hawton
the moment in mental health. the 1960s, the total suicide rate says many other suicide survivors
Thanks to a programme in Detroit had dropped by a third. report similar changes of heart.
that managed to push rates of More recently, deaths seem Efforts are still ongoing to make
suicide to zero within a few years, to have been avoided by a change it physically harder for people to
the approach has spread to in UK law to restrict pack sizes of take their own lives, particularly
health bodies all over the world. the painkiller paracetamol, also in psychiatric hospitals, for
Last week, the UK government known as acetaminophen. From instance by removing objects
appointed England’s first minister 1998, the tablets could only be that could enable hanging.
for suicide prevention, on the sold in small quantities. Ten years A more radical approach is to try
back of a “zero suicide ambition” later, deaths from paracetamol to proactively identify those likely
for patients in the care of the poisonings had halved. to attempt it, an approach called
National Health Service suicide screening.
announced in January. “The philosophy of the zero This was at the heart of the
Reducing the number of suicides suicide movement is a programme that helped start the
is clearly a desirable goal. Yet some refusal to accept that any zero suicide idea. It was pioneered
doctors view the zero suicide such deaths are inevitable” in 2001 by a Detroit-based
movement with alarm, fearing healthcare provider called the
LAURENCE DUTTON/GETTY
that such a challenging goal may Effects like these show that Henry Ford Health System.
actually be counterproductive. suicidal thoughts can sometimes Anyone who came into contact
Some of the earliest successes be transient, says Keith Hawton with its mental health services
in suicide prevention simply at the University of Oxford. was screened for suicide risk, and
involved changes that made it “If you can keep people safe safety measures were taken if
more difficult for people to take until those thoughts diminish, they were deemed necessary.
their own lives. Proponents point you can save lives.” These included asking the person depression screen was offered to
to the unintended benefit seen Hawton recalls a former patient if they had had any thoughts of those seeing doctors for reasons
in the UK in the 1960s when the who had somehow survived a suicide and how they would do it, unrelated to mental health – such
gas supply to people’s homes jump from a high bridge. “When then putting obstacles in place. as those visiting primary care or
gradually became less poisonous. he hit the water, he damaged his Often, this meant getting rid of hospital emergency rooms – so
At the time, deliberate gas body very badly, breaking many any guns from the house – about they could be funnelled into
inhalation accounted for about bones. Yet his first thought was to two-thirds of gun deaths in the US suicide screening if necessary.
are suicides. “Many people think
if you get rid of this gun they’ll
Detroit healthcare provider Henry Ford Health System’s suicide screening,
just go find another gun,” says Ed
Downward trend
introduced in 2001, seemed to help stop deaths entirely, for a year
Coffey, who helped introduce the Within a few years, the suicide
120
Suicides per 100,000 patients

scheme. “For some reason, getting rate among those accessing


100 rid of the one they have fantasised mental health services had fallen,
about seems sufficient.” and in 2009 the number hit zero.
SOURCE: JAMA PSYCHIATRY/ED COFFEY

80
Other elements included The programme’s architects
60 improving access to doctors, and began publicising the results
making sure people had a “safety and it has since been emulated
40 plan”: personalised guidance on by health bodies in more than
Preliminary
data what to do if they had suicidal 100 countries. Methods vary, but
20
impulses, including phone the driving philosophy is a refusal
0 numbers of friends and family to accept that any suicide is
99

00

01

02

03

04

05

06

07

08

09

10

11

12

inevitable. Proponents include


20

to call for help. And a broader


20
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20
20
20

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19

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20

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22 | NewScientist | 20 October 2018


For daily news stories, visit newscientist.com/news

but only in 2009 was it actually someone in hospital against their


zero. “With such small numbers, will is always a delicate balance
a year without any suicides could between their liberty and their
occur by chance,” says Hawton. risk of self-harm. “A zero suicide
Another caveat is that the target risks scaring psychiatrists
headline zero figure was for into depriving too many people
people using mental health of their freedom,” says Holm.
services. In the UK, about seven But the chief grievance is that
in 10 people who take their own zero suicide sets a target that is
lives haven’t had any such contact not realistically going to be met.
in the past year. It is a tall order to “Eliminating suicide completely
expect doctors to save the lives is not going to happen,” says
of people they haven’t met. Hawton. “Throughout history,
“One of the big challenges suicides have occurred.”
is reaching out to people who It is unclear what hearing
are not in contact with health claims that “all suicides are
services,” says David Gunnell of preventable” does to bereaved
the University of Bristol, UK.
Yet these days, the term zero “I believe it should not be
suicide is usually taken to apply a target but a reminder
not just to those under a doctor’s that there are ways we
care, but to everyone. Politicians can reduce suicide risk”
have called for their localities to
become “zero suicide cities”. families. For some, “the idea that
For instance, last year London suicide should not happen makes
Assembly members did so, citing them feel worse”, says Hawton.
Detroit’s example. Sweden has “It adds to their burden.”
adopted a “vision zero” for the Then there is the effect on
entire country. doctors and nurses, says Simon
Amid a gathering wave of Wessely, past president of the UK’s
concern for mental health, Royal College of Psychiatrists.
the zero approach has taken on “Impossible targets rebound on
a life of its own, with a variety of staff morale. You’re increasing
interpretations. For the Mersey the blame culture when it’s not
Care NHS Foundation Trust, one achievable.”
of the first mental health trusts But Fearnley says that’s not
to adopt it in the UK, it includes how it works within Mersey Care.
bereaved parents who are making sure all patients get Although the trust mandates
Need a listening ear? UK Samaritans:
determined their child’s death a safety plan, as in Detroit, as incident reports after each
116123 (samaritans.org). Visit bit.ly/
will not be in vain. well as improving staff training. suicide, he says they have a
SuicideHelplines for hotlines and
So why the scepticism? One Another key aspect is an blame-free culture. “It has given
websites for other countries
problem is that there is little incident report after every people permission to start
evidence to show that some suicide, to work out how it could asking questions about deaths,
elements of the scheme work. System’s mental health patients have been avoided. Mersey Care and being far more curious to ask
There is particular concern over these days is certainly lower than medical director David Fearnley what else we could have done.”
suicide screening, because no before 2001, suggesting services says the goal of zero was crucial The sceptics stress they
questionnaire can reliably have improved. But according to for changing the mindset that applaud new suicide prevention
identify who is going to take their the provider’s published data, the some suicides are inevitable. initiatives, but they don’t think
own life, says Hawton. Studies suicide rate was falling before the In Sweden, though, critics the goal should be framed this
show that there is a higher rate of programme started (see graph, complain that the goal hasn’t way. Some say it would be more
suicide among those classed as left), and the current rate is led to any specific measures or useful to change it from being a
high risk, but about half of people nothing out of the ordinary. significant new funding. So it feels hard target to an aspiration, one
who take their own lives would Suicide is a rare event – with like an empty slogan – one that meant to inspire people rather
have been classed as low risk. an annual rate of about one in comes with potential downsides, than be taken literally. “I believe
“Assessments are extremely 10,000 people – and so the says Herman Holm of Skåne it should not be a target but a
inaccurate,” says Hawton. provider only has a handful of University Hospital in Malmö. reminder that there are ways
How did they work in Detroit? cases a year among its mental Holm worries it could lead to we can reduce suicide risk,” says
Perhaps they didn’t. The suicide health patients. The figure has more compulsory psychiatric Wessely. “If that happens, I’m all
rate among Henry Ford Health jumped up and down since 2001, treatment. The decision to keep in favour.” ■

20 October 2018 | NewScientist | 23


COMMENT

Support needed
Baby Loss Awareness Week is a start, but more must be done to help
those who, like me, have lost a pregnancy, says Petra Boynton

ANYONE who has experienced physical issues – preventing


a miscarriage, stillbirth or accidents and dealing with
other pregnancy loss will pregnancy or birth problems –
understand the pain, distress rather than emotional needs.
and uncertainty that can follow. Providing compassionate care
Because these experiences are also requires us doing better
common, you might hope that at identifying and recording
the way we help people during loss – stillbirth rates are thought
and after the event would be to be underestimated by a third.
uniformly good. The World Health Organization
Unfortunately, this is not the uses an international cut-off point
case. Back in 2016, The Lancet of fetal loss after 28 weeks for
noted that half of the world’s recording stillbirth. Researchers
2.6 million annual stillbirths are and practitioners are asking for
preventable. And there are huge stillbirths to be recognised and
inequalities globally, with 98 per recorded from 22 weeks, allowing
cent of stillbirths happening in for more investigations into its
low-income countries. potential causes. Parents simply
The quality of training for want better opportunities to
healthcare workers is also patchy, recognise their losses and
with staff often struggling to remember their babies.
stay up to date with the latest All this means that healthcare
evidence, or to provide effective workers can’t offer the care they
care in overstretched services. would like to people who have
Where training is provided, it lost a pregnancy. In the UK, the
tends to focus primarily on National Bereavement Care

Smoke signals
with one major exception: programme of education
when they are smoked. In a bid among healthcare professionals
to prevent confusion for police, will be required.
smoking cannabis will remain As groundbreaking as this
UK’s halting step towards cannabis legalisation illegal, regardless of its origin. change is for UK drugs policy,
Those prescribed cannabis won’t the new amendment seeks only
leaves patients in limbo, says Henry Fisher be permitted to medicate to regulate the medical use of
themselves with the aid of a flame. a product that has both an
And getting the medication established medical need and a
ANY government looking to products on prescription as of won’t be easy. Only specialists can substantial non-medical demand.
regulate medical cannabis has November, the UK government prescribe the cannabis, following This is not a recipe for success.
to chart a careful course. If you has chosen to steer far closer to a referral from a doctor. For these Many patients who are
implement a system that is too the second option. regulations to lead to even modest unable to access cannabis legally
permissive, it is simply a facade Cannabis not produced for levels of patient access, a huge due to the overly restrictive
for non-medical use. And one medical use in humans remains regulations will seek it out either
that is too restrictive will fail a class B, schedule 1 prohibited “Many patients will be through the illegal market or by
to provide for patients. substance. Cannabis-based unable to access cannabis cultivating it themselves.
In a policy shift that will legalise medical products, however, will legally due to over Lessons should be learned from
the sale of medical cannabis become schedule 2 medicines, restrictive regulations” other legalisation efforts, notably

24 | NewScientist | 20 October 2018


For more opinion articles, visit newscientist.com/opinion

Pathway is seeking to change


things and “ensure that all
ANALYSIS Human space flight
bereaved parents are offered equal,
high quality, individualised,
safe and sensitive care in any
experience of pregnancy or
baby loss”. This is a welcome
development in my view, because
the poor care I received after one
of my miscarriages turned an
upsetting event into a far bigger
trauma that in turn affected my
future pregnancies, losses and
mental health.
Speaking about the loss of a
pregnancy shouldn’t be a taboo,
but it remains one. Many charities
are pushing for greater awareness
NASA

and to break the silence over


pregnancy loss, with events such

Soyuz crash leaves


as Baby Loss Awareness Week, that can bring food and fuel.
which ended on Monday. All There is a possibility that the Soyuz
of this is admirable, but these craft will be grounded for a long time.

the ISS in a grim spot


conversations can’t just be led NASA is notoriously careful when it
by those directly affected by loss. comes to astronaut lives, and the
They need to be heeded and agency may not wait for Soyuz to
joined by those offering care get to three strikes.
and undertaking research. But what then? NASA retired the
Without joined-up studies, Leah Crane This accident, coming on the space shuttle in 2011 with plans
care and training, and referrals heels of an air leak in the last crewed to quickly replace it with capsules
to sources of support, pregnancy THE near future of human space Soyuz to visit the ISS, may mark a point made by SpaceX and Boeing. Delays
loss will continue to be a difficult flight is looking dangerously uncertain.of reckoning for human space flight. and budget cuts mean these new
path that many of us should not On 11 October, a Russian Soyuz craft That damaged Soyuz, which is spacecraft now won’t be ready until
have to walk alone. ■ carrying two astronauts to the currently docked with the ISS, is the mid-2019 at the earliest. Stringent
International Space Station (ISS) had anonly way for the three astronauts on NASA attitudes about risk and testing
Petra Boynton is a social psychologist issue with one of its boosters, causing board to return to Earth. make it unlikely these flights will be
working in healthcare and author of a crash landing about 400 kilometres The hole has since been repaired, accelerated, even in an emergency.
Coping With Pregnancy Loss (Routledge) from the launch site in Kazakhstan. and is in part of the spacecraft that China is now the only country with
Fortunately, the astronauts are isn’t important for re-entry to Earth’s a working craft capable of taking
alive and well, but the failed flight atmosphere. Even so, the docked humans to space, but it has only ever
in Germany and Canada. Now may complicate things on the ISS. Soyuz will reach the end of its official launched six missions and is currently
on its third attempt to regulate US astronaut Nick Hague and safe lifetime in space in early January. excluded from the International Space
medical cannabis, Germany is Russian cosmonaut Alexey Ovchinin, Station programme. Theoretically, its
struggling with tight restrictions, are in good condition, but after a “For the want of a proverbial Shenzhou craft, which is based on the
low supply and issues of poor bumpy ride – including g-forces of six nail, exploration of the Soyuz design, could dock with the ISS,
doctor education. Canada, or seven times the gravity on Earth’s universe could be set back but such a mission would require an
meanwhile, implemented a fully surface – it could easily have gone by decades” extraordinary act of geopolitical
legal cannabis market for adult another way. The average person negotiation and technical ability.
use this week, having come to the might pass out under forces of 5 g. Past then, Roscosmos will have to If the astronauts do come home
conclusion that the only way to This malfunction is particularly send up an empty Soyuz to get the without being replaced by a new
maintain an effective medical troubling because the Soyuz rocket crew back to Earth. crew, the ISS will be empty for the
market is to also regulate non- and capsule are the only spacecraft That puts the three astronauts in first time since 2000. If it remains
medical sales. currently capable of carrying humans a tough place: they can come home, empty, the lack of upkeep could
The UK would do well to take a to the ISS. All crewed Soyuz launches abandoning the station, or they can doom the already ageing station,
leaf out of the Canadians’ book. ■ are suspended until NASA and the extend their missions until the Soyuz taking down one of the world’s most
Russian space agency Roscosmos or another craft is ready to send new valuable and important assets in
Henry Fisher is the chief scientific figure out what happened and how astronauts to replace them. Supplies space. For the want of a proverbial nail,
officer of Hanway Associates, a global to prevent it in the future. That means will not be a problem, because there humanity’s exploration of the universe
cannabis consultancy in London no one can now reach the station. are several other uncrewed spacecraft could be set back by decades. ■

20 October 2018 | NewScientist | 25


APERTURE

26 | NewScientist | 20 October 2018


Fresh perspectives
THE cenotes of Mexico’s Yucatán peninsula are
undeniably magical places. These large sinkholes,
formed by the dissolution and collapse of
limestone bedrock, expose groundwater
beneath. In this arid land with almost no rivers
or surface lakes, they became a vital source of
drinking water. The discovery of precious
artefacts and human skeletons in some cenotes
confirm the sacred esteem they were held in by
the Mayan civilisation, who believed they were
gateways to the underworld.
This image, and those on the following two
pages, are from the Freshwater Project, a global
odyssey by Swiss photographer Michel Roggo
covering 40 locations across the world between
2010 and 2017. The project serves to illustrate
the phrase ”still waters often run deep”. It also
shows the diversity of environments found in
fresh water, which often matches that of more
familiar terrestrial ecosystems.
The diver in this picture is Camilo Garcia,
investigating the Dos Ojos, or “two eye” cenote,
named for its two openings at ground level. It is
one of the cenotes along the Yucatán’s Caribbean
coast, where fresh water meets seawater in
extensive networks of underwater passages.
A connection between the Dos Ojos and the
neighbouring, larger Sac Actun system,
discovered only in January 2018, makes this the
longest underwater cave system known, with a
total length of over 300 kilometres. Richard Webb

Photographer
Michel Roggo / NaturePL
roggo.ch

20 October 2018 | NewScientist | 27


APERTURE

Top: Michel Roggo learned his craft Bottom: Hidden among water hyacinth Top: Thanks to a natural filtration
among the rivers, lakes and glaciers of plants, a yacare caiman waits for system, Rotomairewhenua, or Blue
the Swiss Alps. In the spring of 2013, passing prey in the Pantanal wetlands. Lake, in New Zealand’s Southern Alps
a prevailing southerly wind brought Sprawling over a vast area from the has the planet’s clearest waters. They
sand from the Sahara to these high- Brazilian state of Mato Grosso do Sul are sacred to the Ngati Apa ki te Ra To,
lying waters. “All the mountains and into Bolivia and Paraguay, the who use them to cleanse the bones of
the glacier were yellow and orange Pantanal is one of the most biodiverse the dead. “You cannot fish or swim in
from it,” says Roggo. In September that ecosystems on Earth. Its caiman this water, or drink or touch it,” says
year, those hues were still visible in population is estimated to number Roggo. He had to obtain special
meltwater sediments from the Gorner 10 million – the largest crocodilian permission to photograph it using
glacier on the Monte Rosa massif. community on Earth. a remote-controlled pole camera.

28 | NewScientist | 20 October 2018


Bottom: Beauty doesn’t need clarity, Top: The forests of the Gunung Mulu Bottom: The “underwater garden”
as shown by the reddish, acidic water National Park in Malaysian Borneo of Ewens Ponds in South Australia is
of Etang de la Gruère in the Jura house a rich diversity of animal and formed of three flooded limestone
mountain range of western plant life. But if Roggo was expecting sinkholes around 10 metres deep,
Switzerland. Laced with tannins from a similar picture when he dipped his connected by shallower watercourses.
surrounding pine trees, such waters head beneath the surface of the The water’s extraordinary clarity lets
rich in dissolved organic matter are Sungai Melinau Paku river, he was the plants and the algal blooms seen
known as blackwaters. The Rio Negro, disappointed. “I saw not a single here thrive up to 6 metres down. As in
a tributary of the Amazon, is perhaps aquatic plant in all the creeks, ponds many places, the fresh water here is
the most famous example, and they and rivers,” he says – just washed-off under threat as agricultural run-off
are common in the southern US, too. debris from the surrounding trees. changes its natural chemistry.

wScientist | 29
20 October 2018 | NewScientist
COVER STORY

THE FASHION
FOR FASTING
Fasting diets seem here to stay and the evidence that they are
good for you is stacking up. Caroline Williams tries one for herself
VINCENT BESNAULT/GETTY

30 | NewScientist | 20 October 2018


A
S I unpack my rations for the next natural state for us than ‘three meals a day’.”
five days, I start to question what I As well as weight loss, proponents claim
have signed up to. For years I have that intermittent fasting could help protect
heard the hype about fasting diets and what against cancer, diabetes and disorders like
they promise: smaller thighs, a clearer head, Parkinson’s and Alzheimer’s disease.
a lower risk of cancer, heart disease and My own enthusiasm at the promise of a
diabetes and the promise of a generally hunger-free fast diminishes somewhat as
longer, healthier life. the kit arrives. I would be living off two packet
But then there is the hunger. Hunger makes soups a day, plus a few crackers, olives and the
me angry, and tired, and generally not a very odd nut bar. It looked a lot like hunger to me.
nice person. So I have always given fasting This particular diet is the brainchild of
diets a miss: the 5:2 diet where you fast for two Valter Longo, a gerontologist at the University
days a week and eat normally the others; the of Southern California in Los Angeles. The
16:8 where you eat within an 8 hour window, basic claim is that fasting just once a month –
and fast for 16; the alternate day fasting. albeit for five days – can mimic the effects of
You name it, it seems someone has tried it. fasting seen in animals, even reversing the
Then I heard about one of the latest trends, effects of ageing. The website of Longo’s spin-
the fasting mimicking diet. If the marketing off company, ProLon, says that the fasting
materials are to be believed, it is the holy grail: mimicking diet is “clinically proven to induce
all the health benefits of fasting without the the [body’s] protectionist and rejuvenation
hunger. The company behind it has even mode”, while providing enough calories that
become the first to be granted a patent for you don’t actually pass out.
boosting human healthspan before the onset Anyone can benefit from this cellular
of disease. So can I really have my cake and spring clean, says Longo: “It doesn’t matter
eat it? I decided to give it a go – and try to get how good your diet is, it doesn’t matter how
to the truth about fasting. much exercise [you do], the body ages and
We have known for decades that restricting the cells accumulate damage.”
calories can have beneficial effects – if not in Thanks to animal studies, we know a fair
humans, then in animals. Many studies have amount about what happens in the body when
found that organisms from single-celled food is scarce. A lack of nutrients kick-starts a
yeasts to rodents age more slowly and live process called autophagy, in which cells break
longer when their calorie intake falls to 40 per down and damaged or dysfunctional parts are
cent of that consumed by a group of animals
eating normally. “Our hunter-gatherer
Constant calorie restriction has never
really caught on in people, however, not
ancestors were adapted to
least because the results didn’t bear out in periods of feast and famine”
primates. Besides, people find it difficult
to restrict their diet in this way for long recycled and used as fuel. The thinking is that
enough to find out if it extends their lives. this system probably evolved to maximise
Fasting has been part of religious practice the chances of surviving famine.
around the world for millennia, but it first Autophagy happens at a low level in healthy
made it into the consumer mainstream cells but becomes less efficient as we age.
around five years ago, on the back of animal Sluggish autophagy lets the inside of cells
studies and research in overweight people gunk up and has been linked to many age-
suggesting that skipping meals could have related diseases including cancer, and to the
numerous health benefits. There is growing ageing process itself. Some researchers believe
evidence that periodically going without that the rise in health problems like cancer
food puts our bodies into a kind of emergency and type 2 diabetes has a lot to do with the
mode, where they conserve energy, make fact that many people no longer go hungry.
repairs and prioritise mental clarity to solve Although the initial findings came from
the problem of finding food. “If we accept research in mice, last year Longo and his
that the Palaeolithic was the environment in colleagues published a study in around 100
which most modern human adaptations were people who either did the fasting mimicking
shaped, including dietary ones, the hunter- diet for five days a month over three months,
gatherers then were adapted to periods of or continued with their normal diet for three
feast and famine,” says Stanley Ulijaszek, a months. The second group then tried the
Don’t eat it nutritional anthropologist at the University fasting diet. When people did the diet, they
all at once of Oxford. “This could well be a more dropped body weight and fat, and ended up >

20 October 2018 | NewScientist | 31


with lower blood pressure and lower levels of Not so fast hour,” he says. If you’re not eating during that
a hormone called insulin-like growth factor-1 Our reporter underwent blood tests to measure time, “you do the math, it’s around 10 hours”.
(IGF-1), which is thought to play a role in markers of health and longevity before and after Add exercise into the equation and the
ageing and disease. They also had lower levels a five day fasting mimicking diet and saw minimal switch can happen even faster, says Mattson.
of inflammation markers and cholesterol, changes in most of them A vigorous run can burn 100 calories in 10
among other benefits. Before After minutes. Get your sports shoes on a few hours
For my little experiment, before I started Fasting blood after your last meal and it won’t take long to
the diet I underwent some blood tests, glucose hit ketosis, he says, leaving me wondering
measuring levels of IGF-1, cholesterol Fasting why I am sticking out a five-day fast instead.
triglycerides
and C-reactive protein (CRP), a marker of Another claim about fasting that almost
inflammation. I also had a body composition Fasting total tempted me in the past was the cognitive
cholesterol
scan to measure any effects on my body fat at effect. Fasters regularly boast about clearer
the Oxford Centre for Diabetes, Endocrinology HDL cholesterol thinking and improved focus. Ulijaszek
and Metabolism. Fredrik Karpe, who runs the observed something similar with modern-day
centre, is sceptical to say the least. “It is very LDL cholesterol hunter-gatherers. While foraging with the

SOURCE: THE DOCTOR’S LABORATORY


important to critically investigate health non-HDL Wopkaimin of Papua New Guinea in the 1980s,
claims for interventions giving great cholesterol he noted that they never started the day with
promises,” he says. breakfast because they preferred to be hungry
CRP* (mg/L)
One crucial question is how long you need while hunting. “They said it made them lighter
to fast to kick-start these processes. After all, on their feet, and more aware of their
IGF-1* (nmol/L)
we know that famines are seriously bad for our surroundings,” says Ulijaszek.
health. Unfortunately, the answer is unclear. 0 5 10 15 20 25 So far, though, no controlled studies have
In a recent review of the health effects of Millimoles per litre (mmol/L) been done to investigate the link between
(unless otherwise stated)
fasting, Benjamin Horne, at Intermountain fasting and cognition in humans, and the
*CRP is a measure of inlammation. IGF-1 is implicated
Heart Institute in Salt Lake City, Utah, in ageing and disease only hints about what might be going on
concluded that no research has yet identified come from mice. Mattson’s group found that
a set line between fasting and starvation, and switching to ketosis gives the brain a boost,
that it probably varies a lot depending on the before the switch to ketosis occurs is stimulating the release of a chemical called
body you have to start with. unknown. Longo says that it takes at least BDNF, which promotes new connections
Another effect of fasting is that the body three days and that shorter fasts, such as between neurons and stimulates neurons
starts to run out of glucose in the blood and the 5:2 diet, don’t last long enough to make to make more mitochondria, which generate
glycogen stores in the liver, which causes a it happen. energy. This could be the ticket to the mental
metabolic switch: the liver starts converting Mark Mattson at Johns Hopkins University clarity reported by fasters.
fats into ketone bodies for the muscles and in Baltimore, Maryland, who studies the His team is conducting a randomised
brain to use as fuel, a process called ketosis. effects of fasting on the brain, disagrees. study in human volunteers to find out
This is why fasting almost always causes “The liver holds maybe 700 calories-worth of whether these brain changes and associated
weight loss of somewhere between 2.5 and glycogen and people’s general daily activity effects are seen in people, with results
8 per cent. But how long you need to fast around the house burns maybe 70 calories an expected in early 2019.
Mental clarity certainly wasn’t something
IN SICKNESS AND IN HEALTH? I experienced. My brain hit the wall early on
day two and on most days during the fast
The evidence for the benefits very low calorie diet instead. fasting might reduce the I gave up trying to work and went back to
of fasting in healthy people is It is early days but initial results risk of type 2 diabetes, while bed. After day three my legs ached like I had
controversial. But it may turn suggest that fasting can reduce research presented at this the flu, apparently a sign of ketosis.
out to work best when the body the side effects of year’s European Society of
is already struggling. chemotherapy, without reducing Endocrinology meeting warned
Animal studies suggest that its power to shrink tumours. that intermittent fasting might
Shock results
while healthy cells hunker down Longo is now trialling his diet damage the pancreas and It was difficult to believe that something
during starvation, cancer cells in people with multiple sclerosis increase the risk of the disease. that made me feel so awful could possibly
don’t, making them more (MS) to see if it can prompt the Either way, people who already be doing me good, especially since my test
susceptible to chemotherapy. body to clear out the immune have the disease and are taking results from before the fast showed that
The fasting mimicking diet cells responsible for the disease insulin should steer well clear. I was already metabolically healthy. I had
(see main story) was designed in and replace them with healthy “If you do insulin plus fasting low levels of “bad” cholesterol, healthy blood
a bid to see if the same applies versions. Again, animal studies or fast-mimicking diet, you sugar and fat levels and very low amounts
to humans. Doctors weren’t keen look promising, but it remains to could actually kill someone,” of visceral fat – the stuff that sticks to our
for their already thin patients be seen if it works in people too. says Longo. organs and which can be a risk factor for
to fast, so Valter Longo at the The evidence around diabetes If you are unwell, you should cardiovascular disease and diabetes. The body
University of Southern California prevention is more unclear. speak to your doctor before scan showed a fair amount of body fat (30 per
in Los Angeles came up with a Some studies suggest that embarking on a diet. cent), but nearly all concentrated on my hips

32 | NewScientist | 20 October 2018


does fasting truly offer a benefit beyond the
fact you inevitably cut a few calories and lose
a bit of weight?
Michelle Harvie, the researcher at
Manchester University in the UK who came up
with the 5:2 diet, told me that based on current
research, we just don’t know. “Intermittent
dieting is a proven method for weight loss…
we don’t know benefits or harms for healthy
weight or underweight people,” she says.

A serving of truth
Many of the original studies of fasting diets
involved overweight volunteers. Even in
Longo’s study of 100 healthy volunteers, two-
thirds started with a BMI of over 25, making
the vast majority overweight or obese. So,
while their health markers such as body mass
index, visceral fat and blood pressure were all
significantly reduced after doing the fast three
times over three months, it isn’t clear whether
DDP/CAMERA PRESS

this can be explained by the simple fact that


they lost weight. Fasting also tends to mean
eating a lot less animal protein and fat, which
have both been linked to cancer, so this might
also be responsible for the effects seen in trials.
Five days of soup and little else each month regeneration. The assumption is that the When a person is a healthy weight, their
would be hard to swallow for many decrepit cells that were removed were bodily clear-out functions work fine on their
replaced by newer, shinier versions. own, says Karpe. “Any normal physiological
and thighs, a pattern that has been linked to The evidence for autophagy and system, in a healthy, lean human being, eating
a lower risk of heart disease and diabetes. regeneration in human trials, however, is well, exercising, doing what the body likes to
After five days of fasting, none of this had purely circumstantial. And we don’t know do, all these things work. That’s why healthy
shifted. The body composition scan revealed whether any new cells are healthier than people, who exercise and eat normal things,
that I had lost just over 1 kilogram in weight, what was lost. Longo concedes that this is live longer than overweight people.”
584 grams of which came from a loss of lean something his team is still working on. Susan Jebb, a nutrition scientist at the
mass and only 168 grams from body fat. This When it came to blood markers of health University of Oxford, agrees: “I am not
was a bit of a shock – one selling point of the and longevity, my results were similarly aware of any high-quality evidence relating
fasting mimicking diet is that it is supposed unimpressive (see graph, left). The only to intermittent fasting among people who
to target visceral fat while protecting lean marked difference was to the hormone IGF-1. are not overweight.”
mass. According to Longo, ketosis doesn’t In the ProLon trials, volunteers saw a Time will tell whether humans benefit
target the visible wobbly bits, only fat around from fasting beyond weight loss. So I can’t
the organs. As I started off with little visceral “When people did the diet help thinking that the wording printed on
fat, it instead targeted my lean mass, he says. the box of ProLon that Longo sent me, which
“From a global health perspective, I find
they had lower body promises “rejuvenation from within”, is
it quite a negative outcome,” says Karpe. weight, fat and cholesterol” premature. We aren’t yet sure that the body
“Half of your change was muscle. The fat clears out damaged cells and replaces them
regions have not changed much at all. significant reduction in IGF-1, which Longo with something better.
That’s not what you intended.” says was still there three months after going For my money, armed with the knowledge
Could it be that the lean mass loss was the back to a normal diet. that most of my body fat is stored away from
result of autophagy? Mice put on Longo’s Whether this adds up to increased longevity, my organs and my blood results are entirely
diet in middle age certainly seemed to have however, is less clear. Epidemiological studies within the healthy range, I think I will stick
some kind of clear-out: their liver, heart and have linked both low and high IGF-1 levels to with my normal diet and take my chances.
kidneys all shrank during the fast and they early death, with high IGF-1 levels linked to Yes, my body could probably handle less
had a temporary cull in the numbers of increased cancer risk and low IGF-1 to wine and chocolate, but going hungry in
some kinds of blood cells. All went back to cardiovascular disease. return for a payoff that may never materialise?
normal within a few days of normal eating, Of course, my experiment of one isn’t very Life’s too short. ■
heralded by an increase in markers of liver scientific, but it did get me wondering: for
regeneration and tentative signs of muscle those of us who are healthy to begin with, Caroline Williams is a consultant for New Scientist

20 October 2018 | NewScientist | 33


ARCTIC-IMAGES/GETTY

34 | NewScientist | 20 October 2018


Full steam
ahead
Recent advances could let us crack the
immense promise of geothermal heat to
power our world. Julia Rosen reports

T
HE Reykjanes peninsula juts out of amounts of energy, and make it accessible to
the south-western tip of Iceland like places far from the volcanic fields of Iceland.
a hitch-hiker’s thumb. Most visitors It could make the dream of abundant
glimpse it from a plane, as they swoop geothermal power a reality.
down onto the runway at Keflavík airport, So far, geothermal energy hasn’t taken off
or through the mist at the Blue Lagoon – a like other renewables. More than a century
popular hot spring. It is an otherworldly after humans started using Earth’s hot water
landscape of rumpled volcanic rocks and and steam to produce power, geothermal
stout cinder cones. The most common signs provides less than 1 per cent of global
of life: tenacious mosses in varying shades electricity. There is no problem with supply:
of green, and the odd wandering sheep. the depths of our planet still smoulder from
Here, the tectonic seam that runs along its violent accretion and the slow burn of
the bottom of the Atlantic, belching out new radioactive decay. The core is a searing
ocean crust between North America and 6000°C, and the heat contained in the upper
Europe, runs aground. That’s what makes this 3 kilometres of the crust would be enough to
place so attractive to people like Guðmundur meet the world’s energy demand thousands
Olaf Friðleifsson, chief geologist at Icelandic of times over.
energy company HS Orka. Just a few Geothermal energy also sidesteps the
kilometres beneath their feet, the staggering problems that plague so many other clean
heat of a volcano bubbles away. All they sources of energy. It is always available,
have to do to harness its power is drill. regardless of whether the wind blows or
Iceland already has plenty of geothermal the sun shines. Alongside nuclear and
energy, but this project is different. hydropower, which have issues of their own,
Friðleifsson and his team are tapping into geothermal offers an attractive source of
temperatures and pressures higher than clean, reliable baseload electricity. But it has
anything we have used before, and building high start-up costs and has historically been
on our growing ability to extract more of restricted to Iceland and other hotspots. The
Earth’s heat. What they are doing could help challenge now is to increase the power and
Steam rises from revolutionise geothermal energy and boost availability of geothermal energy so that it
the Reykjanes this overlooked source of renewable power to can truly compete.
peninsula in Iceland a prominent place in the global energy system. The world’s first geothermal power
It has the potential to unlock unprecedented generator was Italian, built in the verdant >

20 October 2018 | NewScientist | 35


hills of Tuscany in 1904. The seething,
sulphurous hot springs of Larderello attracted
Roman visitors millennia ago, and the Devil’s 2.5GW
valley, as it is sometimes called, supposedly Europe’s 2016 geothermal
shaped Dante’s vision of hell. But others saw power capacity
something else in the hissing steam: untamed
energy. Today, 800 megawatts of power flow vs
from the Larderello fields, supplying 10,000

6500GW
residential and industrial consumers.
Yet humans are still just scratching the
surface. Conventional technologies can only
exploit geothermal energy in spots like Its potential power capacity
Larderello, where heated water runs through with enhanced geothermal
a natural plumbing system easily accessible
systems technology
from the surface. But the Geothermal Energy
SOURCES: EUROPEAN GEOTHERMAL ENERGY COUNCIL,
Association, a US trade group, estimates that DOI.ORG/F5TNQ3
countries have developed just 7 per cent of
the world’s hydrothermal potential.
practical challenge, says Gioia Falcone, an
engineer at the University of Glasgow, UK.

JOHANN S. KARLSSON/GETTY
Digging deeper Sometimes the cracks close up again under
Over the past few decades, however, the immense pressure of the overlying rock.
researchers have been exploring ways to At other times, the rock cracks too much,
extract even more heat, including in regions and water flows too fast to heat up, she says.
not blessed with ideal geology. This new EGS can also have more serious
approach, known as enhanced, or engineered, consequences. In 2006, a commercial
geothermal systems (EGS), can mean adding project in Basel, Switzerland, triggered a geothermal instead. The idea they are
fluid to dry rocks to transport heat to the magnitude-3.4 earthquake that rattled the pursuing has its roots in a series of accidents
surface and generate steam, or fracturing city. No one was hurt, but it made many from the 1980s, when geothermal engineers
impermeable formations so that liquid can residents nervous – they knew a magnitude-6 unexpectedly encountered super-hot
flow through the hot rocks, heating up along quake had levelled the city in the Middle Ages. conditions. The first incident happened at
the way. “It’s taking what nature gives you It isn’t the only case, either. In 2017, an EGS Larderello, where a well struck 380°C water
and figuring out how to make it work,” says project in Pohang, South Korea, was the likely just shy of 4 kilometres down. The drillers
Jeff Tester, a geothermal expert at Cornell source of a magnitude-5.5 earthquake that were totally unprepared for this heat, as were
University in New York. caused $52 million in damage. Both projects the materials they had used to make their well.
EGS could crack open massive stores of were eventually shuttered. They abandoned it when it became clear the
geothermal heat. A 2006 report led by Tester There is no doubt that EGS, like mining, casing wouldn’t hold. Another hole, drilled
found that, in the US alone, the technology fracking for oil and gas, and disposing of waste nearby a few years later, hit the same reservoir
could unlock 130,000 times as much energy as water, can cause earthquakes, says Corinne and blew out in a massive explosion of steam.
the country uses each year. Realistically, we will Layland-Bachmann, an engineer at Lawrence In 1988, something similar happened in
always need other sources of energy, and are Berkeley National Laboratory in California Iceland. But Friðleifsson, who had recently
likely to exploit just a fraction of geothermal’s who studied the Basel case. However, Layland- completed his PhD on another Icelandic
potential. But, says Lauren Boyd at the US Bachmann says the risk of a serious quake volcano, wasn’t surprised by the find. He also
Department of Energy, EGS has another from geothermal production is low. She thinks realised that, if researchers could figure out
important advantage: it will make geothermal incidents like those at Basel and Pohang can be how to manage these fluids, they could
energy available outside existing hydrothermal avoided if developers choose EGS sites wisely capitalise on a geothermal bonanza.
systems. “It’s feasible everywhere,” she says. and reduce injection rates if tremors begin. That is because, above 374°C and 221 bars of
The basic elements of EGS were first tested But perhaps the biggest barrier to the pressure, water transforms into a supercritical
at an experimental site in New Mexico in the approach has been economic. Since Tester’s fluid. As the temperature and pressure rise,
1970s. Since those early days, “we have made report came out, the price of solar and wind says Friðleifsson, water gets lighter and steam
leaps and bounds”, says Boyd. We know more energy has dropped, and cheap natural gas gets heavier until they become one phase.
about what’s going on underground, and have has flooded the market, making it hard for And it’s a totally different beast.
better drilling technology, some borrowed geothermal to expand, says Trenton Supercritical water at 400°C contains five
from advances in the oil and gas industry. Cladouhos at AltaRock Energy, a Seattle-based times as much energy as water at 200°C in
But even so, engineers still face significant geothermal developer. “I’ve been working on a typical geothermal well. It also transfers
hurdles, says Boyd, and only a handful of EGS now for 10 years,” he says. “The market energy twice as efficiently and has a lower
commercial EGS sites operate today. for geothermal just has been flat.” viscosity, flowing out of the ground more
For one thing, creating fractures in So AltaRock and others have focused easily. In 2003, Friðleifsson and Wilfred Elders,
controlled and predictable ways remains a their efforts on a supercharged version of now an emeritus professor at the University

36 | NewScientist | 20 October 2018


Iceland’s Reykjanes power
plant hopes to harness
Earth’s deep heat

we met supercritical conditions by chance,” But Friðleifsson is optimistic the teams will
says Sandra Scalari, at Enel Green Power, ultimately prevail. “You can send a rocket to
which runs the Larderello site. But this time, the moon,” he says. “Compared to that, it’s a
she says, “it was intentional”. There are also piece of cake to drill into the ground.”
supercritical projects planned in Japan, For now, scientists and energy companies
Mexico and New Zealand, and AltaRock is are mostly pursuing EGS and supercritical
looking for funding to deepen an existing well geothermal in places where it is relatively easy
at Newberry volcano in Oregon. The rest of the to reach the temperatures they need – like
world is catching up, says Friðleifsson. “The Iceland, Italy and the American West. But
only difference between us and them is that eventually, many hope these techniques will
Iceland is in the lead.” allow geothermal energy to spread.
Like at Reykjanes, these projects will For the right price, EGS could make
probably use EGS, and share the same risks geothermal energy available across much of
and challenges – plus others associated with the world. Even in places with cooler crust,
working in extreme conditions. “The drill bits it could be used to extract heat for buildings,
basically just start to deform and melt,” says says Tester. And supercritical geothermal
Cladouhos. After that, engineers must figure could unleash enormous energy reserves in
out how to line the wells. Standard casing volcanic areas around the world, says Luchini.
materials aren’t designed for such high “There is a big potential.”
temperatures, or for the corrosive fluids that Ample supercritical resources in one place
bubble up from the depths. These eat away at could even be enough to power surrounding
valves and cement coatings, which expand countries, says Falcone. There has been talk,
and contract in the changing temperatures, for instance, of Iceland supplying power to
risking blowouts. Finally, the standard 1.6 million homes in the UK. “Electricity is
electronics used to measure conditions in the transportable,” she says.
well just get fried. “The equipment is usually But could high-powered supercritical
of California, Riverside, who together lead the made for the oil and gas industry,” says Enel’s projects ever be feasible in all areas? Reaching
geothermal project at Reykjanes, calculated Massimo Luchini, and it was never designed to such conditions in places with cooler, thick
that a well producing supercritical fluid could handle such intense heat. crust, like the US Midwest or eastern Europe,
generate ten times more energy than a There are geological uncertainties too, says would require boring through more than
conventional one. Thomas Reinsch, an engineer at the Delft 15 kilometres of crust, 3 kilometres deeper
Cladouhos says that could make the University of Technology in the Netherlands. than any drill has previously gone. “I wouldn’t
economics of geothermal work out for The tools usually used to probe Earth’s say that we’re going to see supercritical
companies like his. It costs more to drill to depths – like tracking how seismic waves move geothermal developed in Kansas in the
supercritical depths, but the increased energy through the crust – have not been calibrated near future unless you have some magical
production should more than compensate, for rocks at extreme temperatures and way of really reducing the cost of really deep
he says. “EGS is really difficult to do, so you pressures, because it is hard to recreate such drilling,” says Elders.
might as well do it in an area where you know conditions in the lab. That means the results But Cladouhos never says never. Engineers
the economics are going to be helpful.” can be hard to interpret. “We don’t know what are exploring novel drilling methods, using
No one has been able to demonstrate the kind of geology is down there,” says Reinsch. energy waves, high-pressure fluid jets or
increased payout of supercritical geothermal “We are drilling basically into the dark.” lasers instead of metal drill bits. He is holding
so far, but in Iceland they are getting close. In All in all, developing supercritical out hope that a breakthrough will make
2009, Friðleifsson and Elders’s team reached geothermal is a monumental challenge. supercritical geothermal ubiquitous. “Maybe
supercritical conditions when it accidentally the 20-year plan would be supercritical EGS
drilled into a magma chamber at the Krafla anywhere,” he says.
volcano. For two years, that well produced Even if Cladouhos’s dream doesn’t come
a jet of superheated steam, but then a valve
failed and it had to be sealed. 5MW to pass, the potential benefits of supercritical
wells could still help geothermal become a
The Icelandic group then began the Typical power output of major global player, says Falcone.
project at Reykjanes, where they drilled a a geothermal well That future may not be so far off.
well 4.6 kilometres down to access fluids as Friðleifsson’s team plans to get the Reykjanes
hot as 600°C. For the past year, engineers vs well flowing in early 2019, eventually linking
have been pouring cold water down the well, it to a nearby power plant to make the first
which cracks the rocks and is sometimes used
in EGS to increase a reservoir’s permeability.
Now, the team is just waiting for the well
50MW commercial supercritical site in the world.
Even if someone beats them to it, says
Friðleifsson, a geothermal revolution is
Predicted output of
to heat up again before they start testing it. coming. “It is not a question of if, but when. ■
Meanwhile, a new supercritical well has a “supercritical” well
been completed at Larderello. “The first time, SOURCE: DOI.ORG/FMPP3D Julia Rosen is a journalist in Portland, Oregon

20 October 2018 | NewScientist | 37


The disassembly line
Making new molecules requires artful reverse engineering. Now we can
do it at the touch of a button, says James Mitchell Crow

C
HEMISTS have a unique power to the web of connected atoms you want to make, That is why a few chemists think the quickest
manipulate matter. Imagine any then pick it apart, working backwards to plot path to molecules more wondrous than ever
arrangement of atoms you like and a out a series of reactions that, if performed in lies in taking themselves out of the equation.
chemist will have a good shot at stitching the reverse order, will get you to your goal. Most of the biological world is built of
them together. Over the decades, their It is a simple, old and indispensable idea organic, or carbon-containing, molecules.
round-bottomed flasks have helped bring that won its inventor a Nobel prize. Plenty of From hormones to vitamins to poisons,
all sorts of new compounds into being, from the last century’s finest drugs have chemical organic chemists have long tried to both
dazzling pigments to miracle pills and wonder structures so fiendishly complicated that divine their structures and find ways to
materials. But they don’t come easy, not least they could never have been made without make them in the laboratory.
because chemists must do it all backwards. a logical reverse engineering. In the middle of the 20th century, chemists
The tried-and-tested method for planning Yet with thousands of possible ways to make generally tried to synthesise new compounds
how to create a sophisticated molecule starts compounds of even middling complexity, by starting from structures that looked similar
where you would like to end up. You draw out it is tough for humans to spot the best routes. to the target. That yielded handy compounds

38 | NewScientist | 20 October 2018


right enough, from synthetic versions of “You don’t work back to a specific precursor, there’s a surprise, says Matthew Todd,
penicillin to the progesterone hormone just to simpler and simpler structures,” chair of drug discovery at University College
used in the first birth control pill. But there says Michael Sherburn, a synthetic organic London. “I thought Corey was codifying a very
was a large and exotic landscape of potentially chemist at the Australian National University human activity, but right from the get-go his
useful compounds that no one had the in Canberra. “If you do it without bias, then explicit aim in developing retrosynthesis was
faintest idea how to produce in the lab. you end up at starting materials you perhaps to tell a computer how to do it,” says Todd.
In the 1960s, the Harvard University wouldn’t have considered.” It is like planning Corey and his team even developed such
chemist Elias Corey decided to make the a program, called LHASA for Logic and
planning of syntheses more logical.
He realised a good way to do that would
“Chess and chemistry are Heuristics Applied to Synthetic Analysis.
But it wasn’t a genuinely useful tool,
be to work backwards, which led to the very similar. They’re both being hamstrung by the limited speed
name retrosynthesis. and memory of 1970s computers.
Take a blank piece of paper and draw the about plotting moves” Computers have come a long way since
target molecule at the top. Examining the then. For Todd, a key moment came in 1997
bonds holding it together, the chemist will the ascent of a never-before-scaled mountain. when chess world champion Garry Kasparov
pick one and break it. Choosing the right bond Starting from the peak, reverse-plotting the lost to IBM supercomputer Deep Blue.
is where the years of training come in. The route eventually reveals the base camp from “We often talk about chess and organic
bond you break on paper has to be one you which an ascent has the best chance of success. synthesis as being similar,” says Todd.
think you could make in the laboratory, in The moment of truth comes when you Both involve strategically plotting moves.
what would be the final step of the synthesis. crack open a bottle of your starting chemical. “The fact one area had fallen to a computer
First bond disconnected, you go again. Not every route planned on paper works first made me think about the other.”
Step by step, you walk your molecule time, because this is virgin chemical territory. When Todd eventually decided to write a
backwards, stripping away complexity Still, retrosynthesis has become routine for paper on the subject in 2005, he was startled
BRUNO MANGYOKU

until you reach a structure so simple you can planning the most difficult chemical targets at how little had been done since Corey’s
buy it (see diagram, page 40). A particularly (see “Totally synthetic”, page 41). work on LHASA. He ended up speaking with
fiendish structure might take 30 steps to Few chemists go back and read Corey’s Deep Blue’s developers, who told him that
deconstruct to this point. original papers on the subject, but if you do formidable computing power wasn’t >

20 October 2018 | NewScientist | 39


enough. Chess has so many possible
permutations that even a potent computer
can’t crunch through them all. The essential
ingredient of Deep Blue’s success was the
software that encoded the heuristics of chess,
the rules of thumb that allowed it to quickly
discard bad moves.
At the time, no one was interested in
encoding equivalent rules for chemical
synthesis. That’s partly because those rules
are extremely complex. In chess, there are
tens of potential moves from any position.
In chemistry, the number of possible
transformations for a single step of a

BOLDIZSÁR NÁDI/GETTY
synthesis can range from about 80 to
several thousand. Even using the conservative
estimate of 100 choices per step, a 15-stage
synthesis becomes a tree of possibilities with
100 million billion branches. As one industry
insider put it to Todd, it was cheaper to pay
consultancy fees and get top academics to learning retrosynthesis comes from Mark Computers learned the rules of chess.
do the retrosynthesis manually. Waller at Shanghai University in China and Now they have done the same for
But what if we could get machines to teach Marwin Segler at the University of Münster in synthetic chemistry
themselves the rules? That is the promise of the Germany. They developed a neural network, a
burgeoning field of machine learning. Let’s say computing system inspired by the brain, that ChemPlanner to this package that suggests
we want an algorithm to find films that certain taught itself the rules of organic chemistry by whole synthetic routes.
types of people will enjoy. Simply give the sifting through a major database of reactions. Yet there is no published evidence as to
algorithm a long list of films and information The program then predicted routes to how impressive ChemPlanner’s abilities are.
about them, together with a list of the people moderately complex structures that typically And for their part, Waller and Segler say their
who liked them. The machine can then learn to required six synthetic steps to make. Although system is not ready to tackle the most prized
recommend films with certain characteristics the syntheses were not tested in the lab, Waller and challenging targets, such as “natural
to people who like those qualities. and Segler asked chemists to distinguish the products”, the often medicinally useful and
These algorithms are not smart as such, computer syntheses from human efforts in a intricately structured molecules isolated from
they only learn to reproduce relationships double-blind test. They couldn’t. natural sources such as plants or microbes.
discovered in the training data. The effects The trend for artificial retrosynthesis is One man who hopes he can do better is
can be tremendous, however. An algorithm catching on with big players, including the Bartosz Grzybowski at the Ulsan National
created by artificial intelligence firm publishing giant Wiley. It has a commercial Institute of Science and Technology (UNIST)
DeepMind taught itself to play the strategy database called SciFinder that chemists use to in South Korea. He began his career studying
board game Go better than any human. find recipes for individual reactions. Recently, the physics of chemical systems, not cooking
The most promising attempt at machine the firm added a computer-aided tool called up molecules. But, intrigued by the

Retrosynthesis in action
When chemists identify a promising drug, they must then work out how to make it. They use an approach called
retrosynthesis, which deconstructs the target into simpler, starting materials. Here’s how it could work for paracetamol

Paracetamol Phenol (a cheap


HN CH3 starting material)
N

HO HO HO HO
O
Take an imaginary slice through The remaining molecule of interest NO2 groups are easy to The final step gets us
a carbon-nitrogen bond in a now contains an NH2 group, which is add to carbon rings, so to what would be the
molecule of paracetamol, hard to add to a carbon ring like this, the bond to that part starting material of the
yielding two simpler molecules so it is converted into an NO2 group can be broken forward synthesis

40 | NewScientist | 20 October 2018


Totally synthetic
Chemists whip up all manner of useful molecules, many of which are efective drugs.
Through the years, we’ve scaled more and more diicult synthetic peaks

1964 1977 1989 1994 2017


LONGIFOLENE L-DOPA PALYTOXIN TAXOL RESINIFERATOXIN
Chemist Elias Corey at Harvard Starting in the 1950s, Made by corals, palytoxin This chemotherapy drug was Resiniferatoxin is another
University came up with thalidomide was prescribed is the second most toxic first synthesised by two poisonous molecule. At low
retrosynthesis, a method of as a cure for morning sickness. non-protein we know of. research teams, led by doses, it binds a protein found
logically planning how to It was a mixture of two mirror- Just 3 micrograms is thought Kyriacos Nicolaou and Robert in nerves and dials down
stitch together chemicals. image forms, like right and left to be enough to kill a human. Holton, within a month of chronic pain. Synthesising it
One of the first molecules he hands. Doctors didn’t know at Its production was desired each other. Before that, the was daunting, because it
tried it on was longifolene, a the time, but one of these because its huge size and drug, also called paclitaxel, contains several rings of
component of pine resin, and forms caused birth defects. complexity made it the was harvested from the sap atoms fused together. These
one of the aromatic molecules That led chemists to find ways Mount Everest of chemical of rare Pacific yew trees, rings are hard to build and
found in lapsang souchong of making the mirror-image synthesis. Whereas making it scarce and costly. chemically sensitive, so they
tea, which is smoked over forms separately. William thalidomide came in two There are stories from the can easily split apart.
pine fires. These days it is Knowles was the first to find a stereoisomers, palytoxin has 1990s of the relatives of It was prepared in 44
not considered difficult, way of mass producing just 1021, only one of which is the people with cancer going into steps in 1997, but renewed
but at the time no one had one of these forms. It was the correct structure. It was built forests looking for the trees. interest in the drug prompted
synthesised it before. amino acid derivative L-dopa, in eight parts by a team led Synthesis helped lessen Masayuki Inoue of the
used to treat Parkinson’s by Yoshito Kishi at Harvard pressure on the species. University of Tokyo to devise
disease. Since then, such University before they were a shorter way. There is still a
methods have become crucial all connected together. way to go before the drug can
in drug manufacturing. be affordably manufactured.

challenge of artificial retrosynthesis, on molecules its chemists could produce Perhaps it won’t just be chemists asking
he began exploring the mathematics only in low yield or not at all. The team went for advice. A few years ago, Grzybowski warned
that would allow a computer to efficiently on to check eight Chematica retrosyntheses, that his program could make it easier for
navigate one of those vast trees with including one of a natural product. They terrorists to make toxic chemicals. But in
millions of branches. People were mildly all worked and the sale went through, reality it won’t help much. All the program does
bemused when, from 2005, his hardcore with the program being renamed Synthia. is plan a synthesis. It still takes a highly trained
maths papers started turning up in It is a landmark result. But despite the chemist with specialist equipment to realise it.
chemistry journals, Grzybowski recalls. potential, not everyone is as enthusiastic Fears of chemists losing their jobs to AIs are
But it was an essential first step. as Grzybowski. probably also overblown. It is more likely that
From there, Grzybowski encountered the synthesis will become like playing advanced
same problem that Todd had identified: he
needed a way to help his program quickly
“Coming up with a molecule chess where grand masters face off armed
with laptops, says Todd. The computer checks
discount bad moves. He investigated feeding recipe is one thing. Unless for blunders, which are just as important to
it a database of reactions, but “the quality of avoid in synthesis as in chess. “You want to
chemistry you get out is pretty pathetic”, you cook it, it doesn’t exist” make sure you’re not missing something,”
he says. So he and his team took a path others he says. Synthia proved particularly adept
had written off and spent years teaching the In fact, the artificial retrosynthesis concept at spotting reactions in which three or more
program 50,000 rules describing why bonds has proved polarising. “Some believe simple molecules zip together in one go.
change as they do. synthesis is mainly about artistry, and that Even if some see Grzybowski’s work as
Pulling the rules together took a long time, human imagination and intellect, creativity removing the artistry from chemistry, he can
but by 2012, he had shown that his fledgling and knowledge, can never be beaten by a at least take comfort that his work in a sense
program, Chematica, worked in principle. computer,” says Sherburn. But then, they completes retrosynthesis and brings it back
But coming up with a recipe for a molecule said that about chess. Chemistry may be to Corey’s grand vision to drive chemistry
is one thing. “Unless you cook something, more complicated for algorithms to master, forward – by doing it backwards with a
it doesn’t exist,” says Grzybowski. but that day could come. In the nearer computer. ■
He began negotiating to sell the software future, Sherburn says, he can imagine
to chemical supplies firm MilliporeSigma in using programs as he would a colleague, James Mitchell Crow is a science writer based in
2017. The company wanted to test the program to get new ideas or ask for advice. Melbourne, Australia

20 October 2018 | NewScientist | 41


EXCLUSIVE

Memories of
my father
As Stephen Hawking’s final book is published, his
daughter Lucy Hawking relects on its meaning for her

T
HIS is a bittersweet moment. The As my father liked to say, “Where Harry
publication of my father’s last book, Potter has magic, we have science”. I vividly
Brief Answers to the Big Questions, is remember reading him an extract I had just
a triumph in many ways. It is a summation written for George’s Cosmic Treasure Hunt,
of his career, both in science and in public which featured a character with a startling
advocacy on a range of issues that he cared similarity to his own mother. He laughed
about deeply. It is the fruit of decades of so much he nearly fell off his chair. Those
thought and scientific enquiry, as well as were good times.
hard work, his mastery of technical I admired my father all my life, but
communication and his experience on never so much as in the final months of his
the public stage. life, when he fought like a true soldier but
From examination of the nature of life let go at the end with grace. Born on the
itself to exploration of the most mysterious anniversary of Galileo’s death, my father
regions of space, the book is a hymn to rational died on Einstein’s birthday. This final
scientific enquiry. Famously, my father said flourish somehow seemed so typical of
of his 1988 bestseller A Brief History of Time him, an awesome poetry that left us in
that he wanted to see it on airport shelves. bewildered wonderment through our tears.
He certainly achieved that ambition. I hope It feels like no coincidence that his final
this book will fulfil it too. scientific paper, detailed in this book,
But this is also a time of great sadness for concerns symmetry. In the chapter “What is
me. The beginning of this book’s journey inside a black hole?”, my father discusses work
marks a full stop. This is the “last” book. he did with Malcolm Perry, Sasha Haco and
While my father’s legacy will, I hope, live on Andy Strominger on “supertranslations”,
in a myriad of different ways, I have to accept infinite collections of symmetries found in
finally that he himself has gone. areas of space-time far from black holes. These
For the past six months, that hasn’t seemed might help resolve the black hole information
real to me. So much of what we have talked paradox, the puzzle of what happens to the
about, thought about, organised, celebrated information entering a black hole, which has
and mourned since his death has had my generated arguments among scientists for
father as the central figure. It has been as more than 40 years (see “Do black holes eat
though he were still there, still the gravitational information?”, page 45).
force holding us all in orbit. Only now do I Like many other problems on the cutting
have the sense that he is departing, leaving edge of physics that my father worked on, this
us for the final time. remains unresolved. As his lifelong best friend
I went to his house the week before last and Kip Thorne says in his introduction to the
found it deeply moving. I cried over a table book, “Newton gave us answers. Hawking gave
cloth that I bought for him in New Delhi, while I us questions. And Hawking’s questions keep
was on tour in South Asia with one of the on giving, generating breakthroughs decades
five children’s books we wrote together. Odd later.” If Brief Answers is the end, then it is a
though it seems, technically I am my father’s comfort that the big questions live on. ■
most prolific co-author. Together, we created
a series of adventure novels for kids that read Lucy Hawking is a novelist and educator based Lucy Hawking and her
like escapist fantasy, except that the science in London. See overleaf for a review of Brief father in 2015. He died
in all of them was accurate and up to date. Answers to the Big Questions, and an extract on 14 March this year

42 | NewScientist | 20 October 2018


JAMES VEYSEY/CAMERAPRESS

20 October 2018 | NewScientist | 43


An ordinary
genius
Stephen Hawking’s last book reveals
the mind and the man, says Philip Ball

that the physicist would have


Brief Answers to the Big Questions by
preferred the film to have had
Stephen Hawking, Hodder & Stoughton
“more physics and fewer feelings”.
MOST people as I approached this book with
famous as Stephen some trepidation. You know he
Hawking face won’t go wrong with cosmology,
forensically relativity or quantum mechanics,

IAN BERRY/MAGNUM PHOTOS


intimate scrutiny. but when Hawking stepped
But in its way, outside that comfort zone the
Hawking’s results were often touch and go.
personality was The scientific essays included
as insulated as the Queen’s, in this book supply Hawking’s
impermeably fortified by the Greatest Hits: his work with
role allotted to him. mathematician Roger Penrose and environmental degradation, Hawking was first to suggest that
There’s a hint in Brief Answers on gravitational singularities and his contempt for Trump and black holes might emit energy
that he knew this: “I fit the their relation to the big bang; his the regressive aspects of Brexit,
stereotype of a disabled genius,” realisation that black holes will and (albeit not in this book) his the wrong hands.
he writes. emit energy (Hawking radiation); championing of the UK’s National One of the most striking
But his easiness with this idea his speculations about the origin Health Service, made you glad to features of this book, however,
made me uneasy. While it was of the universe in a chance have Hawking on your side. is the lack of extracurricular
delightful to see how in everyday quantum fluctuation; the debate A common danger with such context, from, say, art, music,
life he demolished the laziness (still unresolved) about whether collections is repetition. But the literature, philosophy. In some
that links physical with mental black holes destroy information. recurring and familiar passages pieces, this exposes gaps – for
disability, he did so only by Hawking, as fellow cosmologist are themselves quite revealing, example, when Hawking begins
personifying the other extreme. and long-time friend Kip Thorne for they show Hawking curating an essay called “Is there a God?”
The unworldly intelligence, the outlines in his introduction, his image: the boy always taking with “people will always cling
wry sense of humour, his helped to integrate some of things apart but not always to religion, because it gives
tremendous resilience against the central concepts of physics: managing to put them together comfort, and they do not trust
adversity – such a mind in such a general relativity, quantum again, the man who told us to or understand science”. God, he
body! And then of course, there mechanics, thermodynamics “look up at the stars and not down tells us (as no theologian ever did),
was that computerised voice and information theory. It is a at your feet”. is all about explaining the origin
(another part of his armour). phenomenal body of work. There’s no doubt that Hawking of the universe.
It perhaps suited Hawking that Sometimes there is a plainness cared passionately about the And on what grounds does he
the media were content with the to his prose that is touching even future of humankind and the claim that most people define
cliché – he gave little impression when it sounds like a self-help potential of science to improve God as “a human-like being, with
of caring for the touchy-feely. manual: “Be brave, be curious, it. His advocacy resembles the whom one can have a personal
In the foreword to Brief Answers, be determined, overcome the old-fashioned boosterism of relationship”? Even if true, most
Eddie Redmayne, who played odds. It can be done.” His plea H. G. Wells in later life, tempered people’s notions of a molecule
Hawking in the 2014 biopic The for inspirational teaching, his by an awareness of the dire also bear scant resemblance to
Theory of Everything, reminds us concerns about climate change potential of technologies in what well-informed folk say on

44 | NewScientist | 20 October 2018


the matter, but Hawking would away from any matter has an infinite collection of
not have been happy with that. symmetries known as supertranslations. Each of
There’s a sloppiness to the these symmetries is associated with a conserved
history too, even in science: for quantity, known as the supertranslation charges.
instance, he perpetuates the myth A conserved quantity is a quantity that does
that Max Planck postulated the not change as a system evolves. These are
quantum to avoid the “ultraviolet generalisations of more familiar conserved
catastrophe” of black-body quantities. For example, if space-time does not
radiation. Planck never change in time, then energy is conserved. If
mentioned it in his proposal. RICHARD KAIL/SPL/GETTY space-time looks the same at different points
There’s worse. “People might in space, then momentum is conserved.
well have argued that it was a What was remarkable about the discovery
waste of money to send Columbus of supertranslations is that there are an infinite
on a wild goose chase. Yet the number of conserved quantities far from a black
discovery of the New World made hole. It is these conservation laws that have given
a profound difference to the Old. an extraordinary and unexpected insight into
Just think, we wouldn’t have had Do black holes eat process in gravitational physics.
the Big Mac or KFC,” he writes, the In 2016, together with my collaborators Malcolm
joke perhaps hiding a reluctance information? Perry and Andy Strominger, I was working on using
to probe more deeply. The remark these new results with their associated conserved
appears in a defence of space In Brief Answers to the Big quantities to find a possible resolution to the
exploration, but he shows no Questions, Stephen Hawking information paradox. We know that the three
discernible properties of black holes are their mass,
attempts a new answer to this
“He cared passionately their charge and their angular momentum. These
about the future of decades-old problem, the black are the classical charges that have been understood
humankind and science’s hole information paradox for a long time. However, black holes also carry a
potential to improve it” supertranslation charge. So perhaps black holes
have a lot more to them than we first thought. They
uppose there was no gravity and space-time are not bald or with only three hairs, but actually

S
more inclination to examine the
real reasons for the space race was completely flat. This would be like a have a very large amount of supertranslation hair.
than to reflect on the realities of completely featureless desert. Such a place This supertranslation hair might encode some of
Columbus’s mission. has two types of symmetry. The first is called the information about what is inside the black hole.
But this is all, in a sense, unfair. translation symmetry. If you moved from one point It is likely that these supertranslation charges do
Hawking was a great scientist in the desert to another, you would not notice any not contain all of the information, but the rest might
who had a remarkable life, and change. The second symmetry is rotation symmetry. be accounted for by some additional conserved
in another universe, without If you stood somewhere in the desert and started quantities, superrotation charges, associated
motor neurone disease (well, to turn around, you would again not notice any with some additional related symmetries called
he did like the “many worlds” difference in what you saw. These symmetries are superrotations, which are as yet, not well
interpretation of quantum also found in “flat” space-time, the space-time one understood. If this is right, and all the information
mechanics), we would have no finds in the absence of any matter. about a black hole can be understood in terms of its
reason to confer authority on his If one put something into this desert, these “hairs”, then perhaps there is no loss of information.
thoughts about all and sundry. symmetries would be broken. Suppose there was These ideas have just received confirmation with
We would not deny his right to a mountain, an oasis and some cacti in the desert, our most recent calculations. Strominger, Perry and
ordinariness, and would see his it would look different in different places and in myself, together with a graduate student, Sasha
occasional arrogance for no more different directions. The same is true of space-time. Haco, have discovered that these superrotation
or less than it was. If one puts objects into a space-time, the charges can account for the entire entropy of any
There is every reason to believe translational and rotational symmetries get broken. black hole. Quantum mechanics continues to hold,
Hawking enjoyed his fame, and And introducing objects into a space-time is what and information is stored on the horizon, the surface
that’s a cheering thought. That we produces gravity. of the black hole.
seek to put him on a pedestal is A black hole is a region of space-time where The black holes are still characterised only by their
our problem, not his. We should gravity is strong, space-time is violently distorted overall mass, electric charge and spin outside the
celebrate his extraordinary and so one expects its symmetries to be broken. event horizon but the event horizon itself contains
achievements, both personal and However, as one moves away from the black hole, the information needed to tell us about what has
scientific – but to paraphrase the curvature of space-time gets less and less. fallen into the black hole in a way that goes beyond
Brecht’s Galileo, unhappy is the Very far away from the black hole, space-time looks these three characteristics the black hole has. People
land that needs a guru. ■ very much like flat space-time. are still working on these issues and therefore the
Back in the 1960s, Hermann Bondi, A. W. Kenneth information paradox remains unresolved. But I am
Philip Ball is a science writer. His latest Metzner, M. G. J. van der Burg and Rainer Sachs made optimistic that we are moving towards a solution.
book is Beyond Weird (Bodley Head) the truly remarkable discovery that space-time far Watch this space.

20 October 2018 | NewScientist | 45


CULTURE DON’T MISS

Red sky at night Read


Spanning science and politics,
discoveries and global epidemics,
Nine Pints: A journey through the
money, medicine, and mysteries
A detailed vision of lunar living sends Rowan Hooper into orbit of blood (Metropolitan) by Rose
George should get any science
fan’s heart pumping.
the Chinese. The book opens with (published 2012), Robinson
Red Moon Listen
an American quantum engineer, has an impressive range.
by Kim Stanley Robinson, Orbit
Fred Fredericks, chatting with In Red Moon, he turns his On 23 October at 11.30am BST, the
THE moon is so hot a famous Chinese travel writer, attention to all things lunar, but BBC World Service’s In The Studio
right now. No, not Ta Shu, en route to the moon. this is as much a primer on China follows Cuban artist and activist
literally. It’s the Fredericks is delivering an as a 21st-century superpower as it Tania Bruguera as she installs a
50th anniversary ultra-secure quantum telephone is a description of lunar living. vast heat-sensitive artwork in the
of the moon to the Chinese Lunar Authority Ta Shu (who is obviously a Tate Modern gallery in London.
landings next chief, but the latter drops dead stand-in for Robinson’s own
year, and with it soon after the two meet. musings) contemplates the Subscribe
there is a flurry Framed for the murder, reasons that China has achieved Podcast Here We Are from
of excitement around our only Fredericks, along with Chan Qi, lunar domination: “Money Starburns Audio features comedian
natural satellite that almost makes the pregnant daughter of a top needs to be spent to become Shane Mauss’s journey of discovery.
up for 50-odd years of neglect. Chinese politician, goes on the wealth,” he says. In the Evolution of Alcohol episode,
In September, SpaceX run, shuttling between the moon Ta Shu notes that the global Mauss has an IPA-fuelled chat with
announced that it plans to send and China to elude capture. economy has been around far microbiologist Kevin McCabe about
a paying customer on a flight Robinson is famous for the longer than most people realise, the genetic origin-story of yeast.
around the moon as early as 2023. scientific detail and plausibility and that China has been building
China is launching the Chang’e 4 of his novels. His award-winning up wealth for centuries. Most Visit
robot to the far side of the moon Mars trilogy describes the of the Roman silver coins ever All I Know Is What’s On The
in December, and next year settlement of the Red Planet from minted ended up in China, we Internet, an exhibition opening
Chang’e 5 will collect rocks and the first footsteps on the surface are told. The Yongle emperor in 26 October at The Photographers’
return them to Earth. to the terraforming of the planet the 15th century ordered the Gallery, London, sees artists
So Kim Stanley Robinson’s new centuries later. Whether he is construction of what is now exploring our algorithmically
novel is timely, to say the least. imagining the richness of Beijing even though the imperial driven culture.
Set mostly on the moon in 2047, Neanderthal and Cro-Magnon capital was well established in
Red Moon describes burgeoning culture in southern France Nanjing, and he did it, we are told, Watch
lunar settlements, mostly built by 30,000 years ago, as he did in because his coffers were John Carpenter’s paranoid sci-fi
Shaman (2013), or the expansion overflowing with cash. classic They Live (pictured below)
The future’s bright, and Chinese, of human society across the solar The Great Wall was a similarly is re-released in UK theatres on
in Kim Stanley Robinson’s new novel system, as he did in 2312 gigantic infrastructure project, 26 October in a 4K restoration.
partly launched to use up You’ll never look at adverts in the
surplus wealth, as was the Beijing- same way again. Or sunglasses.
Hangzhou Grand Canal, the oldest Or people, come to that.
and longest artificial river in the
world. Beijing, the Grand Canal,
the Great Wall – and now the
moon. Robinson builds such
a plausible case for Chinese
domination on the moon that in
parts his novel reads like a history.
COLLECTION CHRISTOPHEL/ALAMY STOCK PHOTO

Red Moon’s depiction of its


characters’ inner lives feels
slightly underpowered, but
Robinson has once again created
a deeply realised world that feels
MATJAZ SLANIC/GETTY

more like a peep into our future


than a work of fiction. I only hope
we are as established on the moon
by 2047 as he describes. ■

46 | NewScientist | 20 October 2018


The Department of Biomedical Informatics at Harvard Medical School ofers
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he Department of Chemistry of the University of Wisconsin-Madison is accepting Traditional Master’s Program (48-credit)
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Department of Neuroscience TENURE-TRACK ASSISTANT PROFESSOR


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New Haven, CT 06520-8001 Faculty of Arts and Sciences Department of Chemistry and Chemical Biology
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Position Description: Candidates are invited to apply for a tenure-track assistant
professorship in physical chemistry, broadly defined, including experimental and
theoretical research in areas such as but not limited to atomic and molecular physics,
NEUROSCIENCE FACULTY POSITIONS biophysical chemistry, condensed matter, quantum science and ultrafast spectroscopy.
The appointment is expected to begin on July 1, 2019. The tenure-track professor will
The Department of Neuroscience at Yale University seeks to hire faculty in
be responsible for teaching at the undergraduate and graduate levels. We are seeking
any area of neuroscience, with a preference for candidates who use neuronal
candidates who have an outstanding research record and a strong commitment to
or systems level analysis to investigate circuits, behavior or cognition in
undergraduate and graduate teaching.
health and disease.
Basic Qualifications: Doctorate or terminal degree in chemistry or related discipline
Emphasis will be placed on recruiting at the level of Assistant Professor, but required by the time the appointment begins.
excellent applicants at Associate Professor level will also be considered. We
seek candidates with an exceptional track record, potential for outstanding Additional Qualifications: Demonstrated experience in teaching is desired.
future achievements, and a wish to participate in a dynamic and recently Special Instructions: Please submit the following materials through the ARIeS portal
expanded neuroscience community at Yale that includes the Kavli Institute for (https://academicpositions.harvard.edu/8371). Applications must be submitted no later
Neuroscience, the Program in Cellular Neuroscience, Neurodegeneration and than October 15, 2018.
Repair (CNNR) and the Swartz Program in Theoretical Neuroscience. We are 1. Cover letter
especially interested in candidates who will contribute to the diversity of our 2. Curriculum Vitae with publications list
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and ongoing salary support, and are expected to develop a productive and 4. Outline of future research plans
innovative research program that will include the opportunity to participate in 5. Names and contact information of 3-5 references. Three letters of
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through apply.interfolio.com/54771. Applications will be reviewed as they are Faculty of Arts and Sciences, Harvard University, 12 Oxford St., Cambridge, MA 02138.
UHFHLYHGDQGXQWLOWKHSRVLWLRQVDUH¿OOHGZLWKSULRULW\JLYHQWRWKRVH Phone: 617-496-4088. kinsella@chemistry.harvard.edu
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Harvard is an equal opportunity employer and all qualified applicants will receive consideration
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department. Ideally, candidates should have demonstrated ability
to raise support for their research and lead collaborative projects.
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teaching experience in Chemistry. The successful candidate will
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Review of applications will begin November 15, 2018 and will
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JHSSVYLTHPSACOppAdministrator@uchicago.edu^P[O[OLPYYLX\LZ[

NRC Research Associateship Programs


The National Academy of Sciences, Engineering, and Medicine offers postdoctoral and senior research awards on
behalf of 23 U.S. federal research agencies and affiliated institutions with facilities at over 100 locations throughout the
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We are actively seeking highly qualified candidates including recent doctoral recipients and senior researchers.
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20 October 2018 | NewScientist | 51


LETTERS
letters@newscientist.com @newscientist newscientist

EDITOR’S PICK Weighing the evidence gut in adipose tissue, or even


on healthy fatness worse in non-adipose tissues,
For mammals, matriarchy is second nature notably skeletal muscle and liver.
From Jon Arch, Welwyn Garden Here triglyceride produces
offhand think of any species of large City, Hertfordshire, UK metabolites that cause resistance
long-lived social mammal in which Claire Wilson explains that as to insulin, a feature of type 2
females don’t exert leadership in at many as a third of people who are diabetes and other features of
least one of the definitions used here. overweight have good scores for “metabolic syndrome”, such as
From my own observation, I can say blood glucose, cholesterol and high blood pressure and low-HDL
that sheep and goats follow senior blood pressure (29 September, (good) cholesterol.
females’ decisions in foraging, as do p 20). But why is this? This helps explain why the
African guenon monkeys, such as blue Many factors apart from body glitazone drugs, which shift fat
monkey females, which also defend fat affect these scores. Another, from large visceral to small
territories. Males have other priorities, underappreciated factor is that subcutaneous fat cells, can
often spending time living in all-male not all fat is equal. increase total body fat but
bands with their own rules. Could the The main component of stored improve insulin sensitivity.
authors name seven mammal species fat, triglyceride, is not a problem Those rare individuals who
From Thelma Rowell, in which males provide leadership? (other than for weight-bearing are unable to make adipose tissue
Ingleton, North Yorkshire, UK joints) so long as it is tucked safely and direct their fat to muscle
Chelsea Whyte reports that in only The editor writes: away in lipid droplets in small, and liver are insulin resistant
seven species of mammal do females ■ The authors found leadership in subcutaneous fat cells. It is not and often have symptoms of
exhibit leadership (29 September, p 8). 76 species, seven of which had the direct link between obesity metabolic syndrome.
Leadership is a difficult concept to systematic female leadership. Of and metabolic disease. Exercise is more beneficial than
apply to animals, and indeed different course, females of the remaining The problem comes when you might expect from its effect on
definitions seem to be applied in each species may take the lead at specific triglycerides are stored in large fat body fat content, because it burns
of the seven species cited. I cannot times and in specific situations. cells called adipocytes around the off troublesome metabolites.

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52 | NewScientist | 20 October 2018


“I feel safer with the pilot having the same
outcome as me!”
@wotsapnin isn’t quite ready for the driverless aircraft of the
future (6 October, p 42).

None of this means that losing inadequacy, and let’s also not have government controls on frequency; I understood that most
fat has no benefit in an overweight undermine science by applying spending in healthcare, from Economy 7 meters switch tariffs
individual. If other factors remain the term where it doesn’t belong. Japan’s free market with price as a result of a signal broadcast on
unchanged, it does. controls, to the UK with its BBC Radio 4 longwave.
From John King, relatively socialised medicine. I remember working with the
Things we believe about Humberston, Lincolnshire, UK The only country that doesn’t UK National Grid in its London
economics and the world Pascal Boyer makes assertions attempt to control prices in control centre in the 1980s. An
that he is entitled to make in the healthcare is the US, where health important control it had was
From Nick Pattinson, field of psychology, but he makes costs are vastly higher than in to compare, during the day, the
Stockport, Greater Manchester, UK claims in the field of economics any other advanced country and time shown on a mains electric
Economics is “not an exact that he is certainly not. outcomes are relatively poor. clock – “electric time” – with the
science, after all”, says Pascal If you had asked a psychologist I am sure Boyer is correct in time shown on an independent
Boyer (22 September, p 40). to write an article in which he his psychological analysis, but master clock, “clock time”.
Economics is not a science at all. discussed astronomy, and in that he should be careful about his A task of the control engineer
Where’s the largely agreed body article he asserted that no planet economic assertions. was to adjust system frequency so
of prior knowledge? Where are has a retrograde motion, you that sometime around midnight,
the experiments capable of would have been committing Keeping time on the the clocks agreed. I assume that an
falsifying? the same error. national grid equivalent system operates today.
Where – crucially – are the The first of his “seven flawed
advances made by disproving ideas” – the notion that wealth From David Clarke, Sword-makers were
previous theories? How come is a fixed-size pie – certainly holds Seaford, East Sussex, UK ahead of their time
the same prescription produces in sub-Saharan Africa. I am not sure why Steve Swift
different outcomes? His assertion that prices cannot is having trouble with his From Malcolm Hunter,
Unfortunately, the current be controlled by government electricity tariff timings ( Letters, Leicester, UK
discipline is the best we have, but regulation is wrong in the field of 29 September). He says his meter I read your article about biological
please, let’s not forget its woeful healthcare. All advanced countries takes its timing from the mains materials inspiring attempts to >

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20 October 2018 | NewScientist | 53


LETTERS
letters@newscientist.com @newscientist newscientist

produce metals incorporating consumer and fan of soy and vast swathes of knowledge and According to figures from the
layers, or gradients in their oat milks (the latter comfortingly new fields of space enquiry. Office of National Statistics, 90
composition or structure, in similar in flavour to Coffee- The huge amount of money per cent of UK adults are “recent
order to combine hardness and Mate), I still wonder often at the spent on human space internet users” so any error
toughness (29 September, p 40). sense of consuming milk of any exploration has produced margins associated with offline
Surely there is a long history kind at all. little cutting-edge science. people not being online will be
of layering steel or iron to make Alt-milks typically have One can only wonder what great negligible.
weapons such as swords – with complex and highly robust science has been lost, or greatly
a hard, high-carbon edge, but a packaging that is neither delayed, due to funds channelled Pouring cold water on
tougher, less brittle, lower-carbon compostable nor recyclable, and there instead of robotics and green energy efforts
core. Similarly, “case hardening” far bulkier than that used for milk, machine intelligence.
weapons and armour, using especially as alt-milks seem to From Chris Hildred,
techniques to infuse steel surfaces come only in 1 litre packs. Those who count and Whitby, Ontario, Canada
with extra carbon, or with Is it time for alt-milk producers those who are counted Enid Smith reports that her
nitrogen to create surface nitride to shorten their supply chains, self-sufficiency is thwarted
layers, also has a long history. package more renewably, and tell From Andrew Shand, because she can’t find a washing
us more about what happens to all Irvine, Ayrshire, UK machine that doesn’t use a cold
Are milk alternatives the bits of nut, bean, grain that You say that you surveyed a water fill, which is heated with
really the white stuff? don’t end up in their products? “representative sample of 2026 expensive electricity (Letters,
UK adults” to report on the public 8 September). She should try
From Adam Croucher, Put Martian tourists understanding of science and using cold water washing
London, UK on the no-fly list technology (22 September, p 6). detergent — we’ve been using it
Thank you for Chelsea Whyte’s But then you say “all interviews for years!
article on milk alternatives From Edward Shields, were conducted online”. So, did
(22 September, p 22). It is high Neebing, Ontario, Canada you just guess the views of those The alien life hiding in
time that the question about the As a biologist and a space who are not? plain sight
ecological and health impact of science enthusiast, I strongly
“alt-milks” is addressed in more object to Robert Zubrin’s push for The editor writes: From Quentin Macilray,
detail – please write more! immediate human exploration ■ Our survey was designed by Limassol, Cyprus
The perceived benefits and of Mars (8 September, p 22). Sapio, a market research company Cixin Liu postulates that
harms of these “milks” have As humanity is witnessing on in London that employs accepted highly civilised aliens would
been left to marketing and the almost a daily basis, robotics and industry methodologies to obtain be as incomprehensible to us as
fashions of conscience. As a machine intelligence are opening a nationally representative sample. we are to ants (8 September, p 42).
Could this be the solution to
Fermi’s paradox, “Where is
everyone?” Answer: they’re
already here.

For the record


■ The data artist with whom Hannah
Redler-Hawes co-curated the
[JOYCAT]LMAO exhibition is Julie
Freeman (29 September, p 44).
■ Estimates of the number killed by
Allied bombing raids on Germany in
1939-45 are in the hundreds of
thousands (6 October, p 16).

Letters should be sent to:


Letters to the Editor, New Scientist,
25 Bedford Street, London, WC2E 9ES
Email: letters@newscientist.com

Include your full postal address and telephone


number, and a reference (issue, page number, title) to
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New Scientist Ltd reserves the right to
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54 | NewScientist | 20 October 2018


OLD SCIENTIST
Growing excitement as moon mission nears? Not a bit of it

NASA

WHEN the 24 October 1968 edition of New Scientist


was published, the space race was in full swing. The US
had just completed a successful Apollo 7 mission, sending
three astronauts into orbit for 11 days. We reported no
details of the mission, however, concentrating instead
on the 19th Congress of the International Astronautical
Federation in New York. The success of the Apollo mission
meant that the US was still aiming to have a man on
the moon by the end of 1969, but the conference was
apparently dominated by “the increasingly dim outlook
for future space efforts”.
Budgets were being slashed as US taxpayers grew
weary of funding adventures in space. It seemed that
the once ambitious Apollo programme to explore large
areas of the moon would be drastically cut back. And we
learned that the Soviet Union was encountering problems
with its programme, all but admitting that the Americans
would beat them to the moon. Delegates were “gloomy”,
we said, and the conference itself was “permeated by a
general air of depression”.
Marginally more optimism came in reports of satellite
developments. We predicted there might be as many as
130 satellites in orbit by 1980, and elsewhere that “there
will be about $5 billion worth of spacecraft in orbit” by
the same date. This latter figure would in turn justify the
development of an “orbital scrap collector that could later
be adapted for returning human cargo to Earth”.
In the meantime, a satellite repair vehicle currently The Perfect Gift
under development would ensure that any damaged for Anyone Interested in Space!
satellites could be fixed by remote control from Earth,
although we added a note of caution for the superpowers. Launch them into the worldwide space community with the
“It is easy to imagine the manipulators being used for British Interplanetary Society. Membership includes our
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sabotaging the other fellow’s spy satellite or diffusing his
astronauts, space scientists and thought leaders. Join in
orbital bomb,” we warned. with one of our technical projects and help design the future
Today we look back on the 1960s as being a golden era
of space exploration!
for space exploration. It would appear that hindsight can
be unduly generous. Mick O’Hare ■ From £20/year (Under 22) and £70/year (Standard)

www.bis-space.com
To delve more into the New Scientist archives, go to Telephone +44 (0)20 7735 3160
newscientist.com/article-type/old-scientist/

20 October 2018 | NewScientist | 55


FEEDBACK
For more feedback, visit newscientist.com/feedback

found at least one other animal that A FARMER in Michigan has


equalled dog performance. discovered that a rock he was
“Taking all three groups into using as a doorstop is a meteorite
account, dog cognition does not look worth up to $100,000. When he
exceptional,” said Britta Osthaus of bought another farm in 1988,
Canterbury Christ Church University the previous owner told him his
in the UK. But surely this makes them father had seen the stone come
Jack Russells of all trades, if master of down from the sky in the 1930s.
none? Smart though dolphins may be, After keeping it for 30 years,
Feedback has yet to see one fetch the he brought the 10-kilogram rock
newspaper. to Mona Sirbescu, a geologist at
Central Michigan University.
MANY will call it 2018’s most She determined that it was
adorable trend: 3D-printed 88 per cent iron and 12 per cent
prosthetics for injured animals. nickel – an unusually high nickel
In Canada, a dachshund with content. “What I was holding is
cancer got a new titanium a piece of the early solar system
skull after a brain tumour the that literally fell into our hands,”
size of an orange grew through Sirbescu said.
her original one. The farmer, we presume,
And south of the border, is investigating how many
Mr Stubbs the alligator had his doorstops $100,000 could buy.
AUTHORITIES in the US are giving newspaper Die Rheinpfalz. tail bitten off by other alligators
free helicopter rides to hundreds It’s not the first large-scale at an illegal facility before he was
of feral mountain goats, after the grape heist in the Rhineland- rescued. The good medics of the
animals developed an insatiable Palatinate region, famous for its Phoenix Herpetological Society
thirst for human urine. Riesling, but the 1600-kilogram in Arizona fitted him with a
Olympic National Park in haul exceeds the 600 to 800 kilos 3D-printed tail made from a
Washington state is home to about of grapes stolen last year. Local material known as “dragon skin”.
650 of the goats, which have started vintners suspect that rivals are Meanwhile, students at Armorel
to view hikers as wandering salt licks. responsible, because of the High School in Arkansas created
When not approaching park visitors to specialised equipment required. a 3D-printed foot for Peg the duck,
lick their perspiration, the goats dig up “The motive is jealousy,” one whose foot had been chewed off
soil that ramblers have, er, seasoned, winemaker told Die Welt by a peckish turtle.
damaging the trails in the process. newspaper. Might the culprits Feedback could not substantiate
With few natural predators in the  be suffering from sour grapes? reports that a pig in the UK was A SPATE of nuisance phone calls
park, and no approved contraceptive given a finely crafted wooden leg emanating from the Ke Kai Ola seal
medications, there is little to control PSYCHOLOGISTS have dropped a after pulling the farmer’s infant hospital in Honolulu, Hawaii, were
the goat population. Now rangers truth bomb on dog owners: your son from a pond, saving him the work of an unlikely culprit.
plan to trap as many of the animals pooch isn’t that smart. A team (cat from drowning. After such Hospital director Claire Simeone
as possible, transporting them by people, reckons Feedback) reviewed heroics, the Devon farmer was one of many who received silent
helicopter to nearby forests that more than 300 papers on animal reportedly said, “we couldn’t calls from the centre, which she
offer a more suitable, presumably intelligence to compare dogs with possibly eat him all at once”. eventually traced to a gecko perched
salt-rich, habitat. other carnivores, social hunters and on a touchscreen telephone. Every
domestic animals, including cats, PREVIOUSLY, Feedback reported on time it moved, this four-footed
THIEVES in Germany have made dolphins and pigeons. a Japanese rail company giving staff a telemarketer dialled numbers
off with an entire vineyard’s In many cases, they concluded harrowing lesson in safety by forcing stored in the recent calls log.
worth of grapes, estimated to be that experimenters had set out them to sit in a trench by the track “I had to send out a note to all
worth €8000. Police believe the to prove how clever dogs are, and as a train sped past (8 September). of our staff and volunteers, who
PAUL MCDEVITT

criminals ran a professional seen what they wanted to see. Peter Jacobsen writes that in may have received telemarketing
harvesting machine over the And for each ability that was Cariacica, Brazil, “a bus company calls,” Simeone wrote on Twitter.
entire vineyard, according to the claimed to be exceptional, they sought to sensitise its drivers to the “I immediately hired [the] gecko.”
experience of cyclists by having their
drivers ride stationary bikes in the
A man complaining of a headache discovered road while buses passed them”. You can send stories to Feedback by
he had a 48mm nail embedded in his skull. The London bus drivers, Feedback email at feedback@newscientist.com.
thinks, will be only too familiar Please include your home address.
cement plant supervisor from Chongyang, China, with the experience of being This week’s and past Feedbacks can
told doctors he had no idea how it got there stuck stationary in the road. be seen on our website.

56 | NewScientist | 20 October 2018


THE LAST WORD
Last words past and present at newscientist.com/lastword

Waxing miracle petroleum wax won’t break about 75 per cent potassium the ignition point. Combustion is
down in cooking and might nitrate, which amounts to about almost instantaneous, a column
Recipes often call for zest of unwaxed affect some recipes, creating 2.25 grams per sparkler. If it all of flame and smoke shoots up
lemons. Why are so many lemons froths and making smooth items decomposes to potassium nitrite, over a metre high and I suspect
waxed, what kind of wax is used and look unattractive. But if you are it would yield about 1.9 grams of it forms a mushroom cloud,
what is the best way to remove the not fussy, any ill effects should this chemical. although it was too dark to tell.
wax without harming the zest? be minor. This would be scattered all Standing downwind with
Jon Richfield over the place, but let’s say 1 gram a glass of wine and a cupcake, as
Q Citrus fruits have a robust Somerset West, South Africa goes onto the surface of the cake. the mushroom cloud settles out,
natural waxy covering that If the cake is then cut into 12 slices, would surely mean that the wine
protects them from drying that is 0.08 grams of potassium and the cupcake would exceed a
out and from some kinds of rot. Bright spark? nitrite per slice, which is just over number of Australian and
That kind of wax, in the amount 1 milligram per kilogram of body European food safety standards.
found on fruit, presents no Some restaurants celebrate weight for a 70 kilogram person. Andrew Carruthers
problems to the home cook. customers’ special occasions by So you could have three slices Beaconsfield, Quebec, Canada
The recipes that call for planting burning sparklers onto food, of sparkler-enhanced cake per
unwaxed lemons want to avoid showering it with sparks. Sparklers day and stay within the European Q The main nitrogen-containing
the artificial wax used to coat typically contain an oxidising agent Food Safety Authority ingestion chemical produced when using
some fruit. This is added for such as potassium nitrate, which limit of 3.7 milligrams per day potassium nitrate in pyrotechnics
various reasons. For a start, yields nitrite as a combustion product. per kilogram of body weight. is nitrogen gas, not potassium
industrial fruit production often The European Food Safety Authority However, it’s not likely that this nitrite. I suspect the amount of
depends on seasonal storage specifies a safety limit for nitrite amount of potassium nitrite nitrite produced is very small,
and international distribution ingestion of 3.7 milligrams per day per is produced. if there is any at all.
of produce, which means it is at kilogram of body weight. How much It is also worth noting that Eric Kvaalen
risk of deterioration, rotting and nitrite would someone ingest by potassium nitrite is a food Les Essarts-le-Roi, France
damage. Sometimes, fruit needs eating a slice of sparkler-enhanced additive, often labelled as E249.
washing and other handling so birthday cake? Peter Borrows
vigorous that it damages the Amersham, Buckinghamshire, UK This week’s question
natural wax coating, spoiling Q Sparklers used on cakes will
the fruit’s appearance or conform to a British European Q I think we are all safe from SLEEPOVER
permitting drying or rot. It might Standard, BS EN 15947 category F1, normal sparklers fired off one at My husband is a lark and I am
also be that the fruit just isn’t which means they will contain a time on a cake, even if we don’t an owl when it comes to our
naturally glossy enough, so the less than 7.5 grams of explosive. cut off the black bits in the icing. attitudes to bedtime. This leads
handlers apply an extra coat to However, there are not to discussions about the ideal
attract customers. “You could have three slices only sparklers, there are also time to go to bed. He is convinced
Sometimes the new coating is of sparkler-enhanced cake mega-sparklers. These are very that the best sleep happens
vegetable wax from other sources, a day and stay within the dangerous – and illegal in some before midnight, while I believe
and is much like the original wax, safety limit for nitrite” countries. I have only seen that no matter when you fall
so it need not trouble the cook. them at Australian New Year asleep, you are advised to get 8
But commonly it is a petroleum In fact, sparklers used on cakes are celebrations, on a beach. As hours and whether it starts before
wax much like that used in likely to be somewhat smaller they say: Don’t try this at home. midnight or after has no relevance
candles, and applied in a thicker than this, containing, say, 3 grams They consist of perhaps to the quality of your sleep.
coat than the fruit naturally of explosive. The black powder 150 normal sparklers bundled Who is right?
produces, to make it look extra (sometimes called gunpowder) together with wire. One central Rita Szilagyi
glossy. Though harmless, used as the explosive is typically sparkler is left sticking up, used as Szeged, Hungary

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