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Ultrasonic characteristics of 21 adrenal neoplasms (19 pa- shape with smooth contours. One primary lesion had a
tients) examined by gray scale ultrasonography are reviewed. tonguelike projection anterior to the kidney (fig. 3).
The significance of the adrenal-renal cleavage plane is dls- Another patient with metastatic lung carcinoma demon-
cussed. In our experience the cleavage plane only has defl- strated acoustical shadowing behind the mass related to
nite localization value when it separates the adrenal gland
calcifications within the lesion (fig. 4).
from the kidney on all uftrasonographic sections. Compres-
An echogenic cleavage plane through the entire adre-
slon of the posterior wall and/or anterior displacement of the
inferior vena cava was seen In about two-thirds of the right
nal-renal interface was definable in nine lesions (fig. 3).
adrenal tumors. The difficulty in examining left adrenal The cleavage plane was partial in four and not demon-
masses is emphasized. Ultrasonography has proved to be an strated in eight (fig. 5). In nine right adrenal masses, a
excellent screening procedure for adrenal tumors. similar echogenic interface was noted between the liver
and adrenal lesion (figs. 2 and 3). The interface was
Although ultrasonography of the adrenal gland is used partial in one and not observed in three masses.
for evaluation of clinically suspected adrenal masses [1- Nine of the 13 right adrenal masses demonstrated
6], only a few reports have documented its effectiveness either anterior bowing of the inferior vena cava and/or
with gray scale equipment [7, 8]. We review our expeni- impression upon the posterior wall of the inferior vena
ence with 21 adrenal neoplasms, stressing the ultrason- cava (figs. 4 and 6). The inferior vena cava was not
ographic features which have proved most helpful as observed in three patients and appeared normal in one
well as the diagnostic pitfalls. adrenal lesion.
The series included 19 individuals with 21 proven The adrenal glands lie cephalad, anterior, and some-
adrenal neoplasms. The 11 males and eight females what medial to both kidneys. The right adrenal has a
ranged in age from 7 months to 70 years. Histologic triangular shape and the left is slightly cnescentic. Nei-
proof was available by percutaneous biopsy, surgery, or thor is usually greater than 3 cm in any dimension. The
autopsy in seven patients. In the other 12, at least two of right gland is posterior to the inferior vena cava while
the following modalities were used for diagnostic conf in- the left adrenal is located to the left of the aorta; these
mation : intravenous urography, angiography, radionu- features prove to be valuable landmarks on cross-sec-
clide adrenal imaging, and computed tomography. There tional imaging. With standard scanning techniques and
were 13 right adrenal masses and eight on the left. Of presently available equipment, only lesions of 3 cm or
the 19 patients, three had primary adrenal carcinoma, larger can be reliably imaged, although normal adrenal
four had neuroblastoma, and 12 had metastases. In the
patients with metastases, the primary tumors were lung
carcinoma in six, breast carcinoma in four, and mela-
noma in two.
All patients were examined by gray scale technique
utilizing progressive generations of a commercially avail-
able scanner. A 2.25 or 3.5 MHz internally focused
transducer was used, depending on patient size. In the
majority, recording was accomplished with a 70 mm
camera. Scans were obtained at 1 cm intervals or less in
both the longitudinal and transverse supine positions.
Slightly oblique planes were frequently used to optimally
visualize adrenal-renal interfaces. Nine patients were
also examined in the prone position as indicated. ...
Ultrasonographlc Features
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Fig. 4.-Calcified right adrenal metastases from lung carcinoma.
Supine longitudinal sonogram demonstrates mass (M) indenting poste-
nor vena cava. Note several sharp bands of acoustical shadowing behind
Fig. 2.-Right adrenal
metastatic lesion from lung primary tumor.
small calcifications.
Supine longitudinal scan
through largest mass (M) in series. Mass is
sharply margmnated . contains internal echoes, and is clearly separated
from liver (L) and kidney (K).
Fig. 7.-Supine longitudinal sonograms on two patients with masses (M) in right suprarenal region. Both demonstrate poor “renal-mass” interface.
A, Adrenal metastasis. B, Renal cell carcinoma.
!
Fig. 8.-Prone longitudinal sonogram, 6 cm to left of midline, showing Fig. 9.-Prone longitudinal scan demonstrating hypoechoic “mass”
left adrenal mass (M) containing internal echoes. Mass was not apparent anterior to upper pole of left kidney. This represents prominent median
with supine scanning. K = kidney. lower pole of normal spleen (5). a finding confirmed by computed
tomography. K = kidney.
adrenal gland are metastases, particularly from lung and 3. Lyons EA, Murphy AV, Arneil GC: Sonar and its use in
breast cancer and melanoma [11]. This is also true in our kidney disease in children. Arch Dis Child 47 :777-786, 1972
small group of patients studied by ultrasonography. No 4. HoIm HH, Knistensen JK, Rasmussen SN, Pedersen JF:
differences were noted in the ultrasonographic features Ultrasonic
diagnosis of juxtarenal masses. Scand J Urol
Nephrol 15:83-88, 1972
of adrenal metastases or primary tumors. Forsythe et al.
5. Davidson JK, Morley P, Hurley GD, Holford NGH: Adrenal
[7] suggest that because of frequent necrosis associated
venography and ultrasound in the investigation of the
with adrenal metastases, with resultant areas of sono-
adrenal gland: an analysis of 58 cases. Br J Radiol 48:435-
graphic lucency, these lesions may resemble adrenal 450, 1975
cysts. This phenomenon was not observed in our pa- 6. Keklet H, Blichert-Toft M, Hancke 5, Pedensen JF, Kristen-
tients. In part, the difference between our findings and sen JK, Lockwood K, Hasner E: Comparative study of
those in Forsythe et al. [7] may be due to changes in ultrasound , ‘311-19-iodochoiesterol scintigraphy, and aor-
ultrasonographic equipment since their report. tography in localizing adrenal lesions. Br Med J 2:665-667,
Numerous noninvasive and invasive imaging modali- 1976
ties such as adrenal scintigraphy, intravenous pyelogra- 7. Forsythe JA, Gosink BB, Leopold GA: Ultrasound in the
evaluation of adrenal metastases. JCU 5 :31-34, 1977
phy, angiography, and computed tomography now exist
8. Ghorashi B, Holmes JH: Gray-scale sonographic appear-
to evaluate adrenal tumors. Ultrasonography is an excel-
ance of an adrenal mass: a case report. JCU 4:121-123,
lent screening method for evaluating the adrenal gland 1976
when a mass is suspected and will yield information 9. Sample WF: A new technique for the evaluation of the
about the internal consistency of a lesion. adrenal gland with gray-scale ultrasonography. Radiology
124:463-469, 1977
10. Rao Raja AK, Silver TM: Normal pancreas and splenic
ACKNOWLEDGMENTS variants simulating suprarenal and renal tumors. Am J
We thank Carol Perkins and Cathy Hams for technical assist- Roentgenol 27 : 535-537, 1976
ance, Eugene Szwarc for photography, and Linda Stromme for 11 . Zornoza J, Bracken A, Wallace 5: Radiologic features of
manuscript preparation. adrenal metastases. Urology 8:295-299, 1976