Professional Documents
Culture Documents
Pre-exposure
prophylaxis
Beatriz Puzon-Quiambao, MD
Research Institute for Tropical Medicine
SUCKING
APPARATUS
0
'93 '95 '97 '99 '01 '03 '05 '07
(3Q)
Only 17 rabies diagnostic labs serving
the whole couuntry DA-BAI, 2008
RABIES CASES
Human Rabies cases,
Philippines
396
400 362 359
350 337 321
293 288
300
265 248 271
250 214
200 199
150
100
50
0
'96 '97 '98 '99 '00 '01 '02 '03 '04 '05 '06 '07
partial
DOH, 2008
160000
140000
146306
136429
120000
120305
100000 113379
104530 118155
80000 102145
87928
60000
70340
40000 68264
65434
20000
0
'96 '97 '98 '99 '00 '01 '02 '03 '04 '05 '06
The cost of the Tx of bite victims seeking PEP every
year is a significant economic burden
2000
1500
1000
500
0
< 5 yrs 5-9 yrs 10-14 15-18 19-39 40-59 >=60
yrs yrs yrs yrs yrs
male female
N=190
N=155
N=140 N=118
N=84
N=76 N=72
Lang et al, J Trop Pediatr, 1999
Diphtheria: ELISA ≥0.01 IU/mL Lang et al, J Trop Pediatr, Nov 07
GMT of Anti-rabies Ab
0.5 IU/ml
Cong Vien et al, Transac Roy Soc Trop Med Hyg, 2008
Doi:10.1016/j. trstmh. 2007.11.010
A phase IV, prospective, open-label, randomized, single center
study to assess the immunogenicity and safety after pre-exposure
vaccination with 2 or 3 intradermal doses of Purified Chick Embryo
Cell Rabies Vaccine in healthy school children
(5-9 years of age) in the Philippines
1.35 1.81
GMT [IU/mL]
+/- 95% CI
0.5 IU/mL
0.1
2 dose 3 dose
63/73 69/70
86% 99%