Clinical Characteristic of Latent Tuberculosis Infection

Rizky Arisanti Maharani, Retno Asih Setyoningrum

Department of Child Health,
Faculty of Medicine, Universitas Airlangga / Dr. Soetomo General Hospital, Surabaya
Indonesia
BACKGROUND METHODS
• According to World Health Organization (WHO), • Design : A descriptive study
there are about 8.6 million incident cases of
tuberculosis (TB) and about 1.3 million deaths • Sample : Outpatient with LTBI
from TB annually.
• Close contacts of active TB patients are at high • Setting : Pediatric respirology clinic at
risk of both active and latent tuberculosis Dr.Soetomo General Hospital
infection (LTBI). Surabaya
• Nearly one third of the world's population
contracted LTBI, and that 10% of these carriers • Period : January 2006 – December 2015
will develop an active TB infection.
• The diagnosis and treatment of LTBI have • Data collection : Medical record of outpatients
become mandatory to reduce the burden of TB diagnosed with LTBI. LTBI was
worldwide. determined as having close
• Objective:To describe the patient characteristics contact active TB and showed
of Latent TB infection. positive tuberculin skin test (TST)

RESULTS
During the study, there was 103 patients enrolled. The characteristics of the patients are showed in table 1.
Table 1. Patient characteristics
16
Characteristics
Gender (%) Pediatric outpatient clinic
• Male 54 (52.4) 14

• Female 49 (47.6)
Age (%)
12 Community Health Centre
• < 2 years 49 (47.6)
• 2 – 5 years 34 (33)
10
• > 5 years 20 (19.4)
Others
Age at diagnosis (median) years 0.2 – 15 (1.5)
Nutritional status (%) 8

• Normal 55 (53.4)
• Wasted / moderate malnutrition 32 (31.1) 6

• Severely wasted / severe 16 (15.5)

malnutrition 4

Contact (%)
• Positive AFB sputum smear 38 (36.9)
2

• Unknown AFB sputum smear 65 (63.1)

Treatment (%)
0
• Completed 88 (85.4)
2006 2007 2008 2009 2010 2011 2012 2013 2014 2015
• Discontinued 15 (14.6)
• Failure on treatment 0 Figure 1. Referral Case in the early admission
CONCLUSION
Children under 2 years old with close contact of positive AFB sputum smear are tend to develop LTBI,
with no evidence of progression to active TB.