Tafero 25mg Tablet

Tafero EM 200mg/25mg Tablet is a combination of two anti-HIV medicines: Emtricitabine and

Tenofovir. They prevent HIV (virus) from multiplying, thereby reducing the amount of virus in
your body. They also increase the CD4 cell (white blood cells that protect against infection)
count in your blood.

Uses of Tafero EM Tablet: Tafero EM 200mg/25mg Tablet is used in the treatment of HIV
infection. Tafero EM Tablet side effects: Side Effects of Tafero EM are Nausea, Vomiting,
Diarrhoea, Flatulence, Insomnia (difficulty in sleeping), Headache, Depression, Rash.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do
not chew, crush or break it. Tafero EM 200mg/25mg Tablet is to be taken with food.

Tafero Mechanism of Action: Tafero contains an ingredient Tenofovir Alafenamide Fumarate;

which is nucleotide reverse transcriptase inhibitor. TAF is an ester prodrug of anti-retroviral,
Tenofovir. TAF is converted into tenofovir in vivo by using acyclic nucleoside phosphonate
Drug tenofovir decrease the normal DNA building blocks by lacking of OH molecules which is
essential for phosphodiester bond linkage. The phosphodiester bond linkage is responsible for
DNA elongation This leads to chain termination and prevents proviral DNA transcription.
Pharmacokinetics: Absorption: The absorption of tablet Tafero is normally high. Tmax is
monitored at 1 hour after oral administration of tablet Tafero The volume of distribution is not
available Protein binding: Tenofovir Alafenamide fumarate is highly bound to plasma protein;
nearly 80% of drug is bounds to protein. Metabolism: TAF is hydrolyzed into Tenofovir which is
occurs within the cells, it is a major metabolite. Tenofovir is phosphorylated into active
metabolite called tenofovir diphosphate. Metabolism occurs by cathepsin A (Liposomal
Protective Protein) in peripheral blood mononuclear cells and macrophages; and by Carboxyl
esterase 1 (CES1) in hepatocytes. In both conditions, tablet Tafero is safe to use; but prior
information given to physician in case of pregnancy condition. There is a chance of placental
transformation during labor Pediatric and geriatric usage not recommended.

Precaution of Tafero: If patient having lactic acidosis and severe hepatomegaly with steatosis,
care should be taken while that patient treated with Tafero (TAF) Lactic acidosis/severe
hepatomegaly with steatosis Severe acute exacerbation of Hepatitis B after discontinuation of
treatment Risk of development of HIV-1 resistance in patient’s co infected with HBV and
HIV-1

Tafero is stored under temperature at 30oC (86oF).

Tafero EM Tablet related warnings: Alcohol, Pregnancy, Lactation, Driving, Kidney, Liver

Related website : https://applepharma.us/product-view.php?id=109/HepatitisB-Hetero-

Tenofovir-Alafenamide-25mg-Tafer