You are on page 1of 8

S p o ns o r e d F e a tu r e  1

PanOptix™
Enlightening
Conversation
Highlights from the Prague 2016
Alcon Multifocal IOL User Meeting

Alcon Consultancy Panel:


Thomas Kohnen, Frankfurt, Germany
José Alfonso, Oviedo, Spain
Francesco Carones, Milan, Italy
Ruth Lapid-Gortzak, Amsterdam, The Netherlands
Joaquim Murta, Coimbra, Portugal
Kjell Gunnar Gundersen, Haugesund, Norway
Bilgehan Sezgin Asena, Izmir, Turkey
Martin Kacerovský, Prague, Czech Republic
Mike Holzer, Heidelberg, Germany
Ozana Moraru, Bucharest, Romania
Dominique Monnet, Paris, France
Mayank Nanavaty, Brighton, UK
Islam Hamdi, Jeddah, Saudi Arabia
Ahmed Sedky, Cairo, Egypt

This supplement reflects the opinions and experiences of meeting participants in Prague on June 24, 2016. Data presented are representative of each
participating surgeons’ own experience, and do not arise from formal clinical studies. Trademarks are the property of their respective owners.

www.alcon.com
2
 S p o ns o r e d F e a tu r e

Today, patients are increasingly


undergoing cataract surgery earlier in Traditional trifocal IOLs
life, and the procedure has become an
extremely rapid and refined process:
small incisions, quick recoveries, and
typically, great visual outcomes. For
well over a decade now, surgeons have
been able to offer presbyopia-correcting
intraocular lenses (IOLs), and with them,
the option of spectacle independence
for presbyopes. Until fairly recently, Two step heights = two add powers/focal points in addition to distance.
multifocality meant bifocality: light energy Due to the nature of diffractive orders, when there are three focal distances,
is primarily directed to near and far the intermediate focal point must be 2 x near: (Distance: ∞, intermediate at 80
focal points. cm and near at 40 cm).
Multifocality, by its nature, is an optical
compromise – and the trade-off of two Quadrifocal IOLs
or more focal points on the retina is
associated with some level of photic
phenomena, such as halo and glare
(1). Most bifocal IOLs typically deliver
excellent near and distance vision – but
at the expense of intermediate vision. So
the challenge when designing a better
multifocal IOL is to provide continuous
visual acuity over near, intermediate
and distance, with minimal photic Three step heights = three add powers/ three focal points (plus distance from
phenomena, with the greatest amount base curve). Due to the diffractive principle, when there are four focal distances,
of light reaching the retina for optimal the first intermediate focal point must be 1.5 x near, and the second
contrast sensitivity. intermediate focal point must be 3 x near (Distance: ∞, extended intermediate
In July of 2015, Thomas Kohnen, at 120 cm, preferred intermediate at 60 cm, and near at 40 cm).
MD, PhD, professor and chair of the
Department of Ophthalmology, Goethe ENLIGHTEN™ Optical Technology
University in Frankfur t, Germany,
implanted the first Alcon AcrySof ®
IQ PanOptix™ IOL worldwide into
a patient (2). PanOptix™ is Alcon’s
latest multifocal IOL, a trifocal lens that
features an innovative optical technology
designed to help patients adjust more
naturally to their new vision. It does
this in part by providing a comfortable
range of near to intermediate vision (40– The quadrifocal design is manipulated so that the extended intermediate focal
80 cm) with a crisp focal point at 60 cm, point (120 cm) is redistributed to the distance focal point for amplified
and by optimizing light transmission to performance. This results in two step heights = two add powers/two focal
the retina (3–7). points (plus distance from base curve). Light is still split three ways (Distance: ∞,
Since its launch, PanOptix™ has been preferred intermediate at 60 cm, and near at 40 cm).
adopted by some leading surgeons,
some of whom assembled in Prague on
Friday, June 24, 2016. They shared their Box 1: The technology that underpins PanOptix™ (3, 8, 9)
S p o ns o r e d F e a tu r e  3

Preoperative Postoperative
experience with the lens, their outcomes,
and their thoughts on patient selection. 0.37±0.24 0.73±0.24
UDVA
(0.05–1.0) (0.2–1.0)
How does PanOptix™ work?
Prof. Kohnen explained that it’s perhaps 0.51±2.24 -0.09±0.36
Sphere
easiest to view PanOptix™ as a (-6.50–6.00) (-1.00–1.00)
quadrifocal IOL manipulated to act as a -0.48±0.46 -0.28±0.33
trifocal one. “In essence, the quadrifocal Refractive cylinder
(-1.50–0.00) (-1.00–0.00)
design is modified so that the extended
intermediate focal point (120 cm) is 0.55±0.40 0.39±0.35
Keratometric cylinder
redistributed to the distance focal point (0.00–1.50) (0.00–1.50)
for amplified performance,” explained CDVA
0.79±0.26 0.89±0.20
Prof. Kohnen. Alcon calls this innovative (0.1–1.0) (0.2–1.0)
diffractive lens design ENLIGHTEN™
(ENhanced LIGHT ENergy), and it results Table 1. Patients' (n=90) refractive and decimal visual acuity results preoperatively and six months
in the creation of three foci; distance, an after PanOptixTM IOL implantation. CDVA, distance-corrected visual acuity; UDVA, uncorrected
intermediate at 60 cm, and near at 40 distance visual acuity. Data courtesy of Dr. Alfonso.
cm (See Box 1, “The Technology That
Underpins PanOptix™”). At a 3 mm follow-up results of the efficacy, safety CDVA of the patients. Dr. Alfonso
pupil diameter, PanOptix™ transmits and predictability of the lens in 90 eyes emphasized that, “all patients with
88% of light to the retina, which is higher (45 patients, aged 65.18±8.45 years) after cataract in this cohort experienced
than other traditional trifocal multifocal successful IOL implantation. PanOptix™ improvements in vision, and only two
IOLs, like FineVision (PhysIOL) and the was not implanted in patients with hyperopic eyes lost one line of vision –
AT LISA tri 839 (Zeiss) (3, 6, 10, 11). cornea, retina or optic nerve pathology, although this was likely attributable to
Ruth Lapid-Gor tzak, MD, PhD or in eyes with previous ocular surgery. the lower image magnification that is
of the Academic Medical Center in He operated on both eyes during the typical of all diffractive implants.”
Amsterdam and Retina Total Eye Care same week, and all were femtosecond Dr. Lapid-Gortzak reinforced the
Clinic, Driebergen, The Netherlands, laser-assisted procedures, performed theme of PanOptix™’s association
provided some practical examples of with an Alcon LenSx ® laser system to, with refractive stability and accuracy.
the importance of the 60 cm distance in in all cases, make a 4.8 mm-diameter She presented the results of her first
daily life: cooking, taking food from the capsulotomy (ideal for the 4.5 mm optic 50 bilateral implantations (25 patients
fridge, and using a computer. PanOptix™, zone of the lens). The visual acuity and aged 54.8±8.1 years). In terms of
uniquely, provides a 60 cm intermediate refraction results were satisfactory refractive accuracy, she found that
focal point (6,7). It’s also less dependent (Table 1) – great improvements were 79.4% of eyes were within ±0.25 D of
on pupil size than its predecessor seen in postoperative uncorrected target, and 100% were within ±0.5 D.
multifocal IOL design, the AcrySof ® IQ distance visual acuity (UDVA), corrected PanOptix™ improved UDVA, CDVA
ReSTOR®, due to the fixed light allocation distance visual acuity (CDVA), sphere and uncorrected near and intermediate
within the its 4.5 mm diffractive diameter, and cylinder correction, compared visual acuity (UNVA, UIVA) following
compared with the 3.4 mm and 3.6 mm with preoperative values, where 89% surgery, and these gains were stable
diffractive zones present in ReSTOR® of the eyes were within ±0.50 D of the over the three-month follow-up period.
+2.5 and +3.0, respectively (3, 12, 13). attempted spherical correction; all eyes Figure 1 represents the photopic
were within ±1.0 D using SRK-T and binocular defocus curve three months
How well does PanOptix™ work? Holladay II formulas and A-constant postoperatively, showing a continuous
José Alfonso, MD, PhD, of the Corneal of 119.1. The efficacy (postoperative range of vision (visual acuity above 0.1
and Lens Surgery Department at the UDVA/preoperative CDVA) and safety LogMAR) from 0 D to -3.0 D defocus,
Instituto Oftalmológico Fernández- (postoperative CDVA/preoperative which corresponds to distance to 33 cm.
Vega, University of Oviedo, Spain, has CDVA) indices were 0.92 and 1.13, Dr. Lapid-Gortzak asked her patients
implanted PanOptix™ since July 2015, respectively, which are great results if they were satisfied with PanOptix™;
and he presented his own six-month taking into account the high preoperative 88.2% of the patients were very satisfied.

www.alcon.com
4
 S p o ns o r e d F e a tu r e

its primary focus was to establish the


Diopters personality characteristics that might
4 3.5 3 2.5 2 1.5 1 0.5 plano -0.5 -1 -1.5 -2 -2.5 -3 -3.5 -4 influence patient satisfaction following
1.6 -0.2
multifocal IOL implantation, it did find
1.25 -0.1
that four key factors were correlated
1.0 0
with overall satisfaction of the procedure
0.8 0.1
0.63 0.2
(irrespective of personality type). These
0.5 0.3 were: low astigmatism, good visual

LogMAR
Decimal

0.4 0.4 function, low spectacle dependence, and


0.3 0.5 fewer halos/ less glare. Dr. Sezgin Asena
0.25 0.6 reported that PanOptix™’s attributes
0.2 0.7 may play a key role in assuring patient
0.15 0.8 satisfaction, and noted that one could
0.1 0.9
leverage this to expand the patient pool
0
80 60 40 cm
1.0
suitable for this form of presbyopia
correction. According to Dr. Sezgin
Asena, “Multifocal IOL candidates could
Figure 1. Binocular defocus curve evaluation of PanOptixTM IOL after 3-month follow-up. Green line take too much chair time and sometimes
indicates visual acuity of 0.1 LogMAR (0.8 decimal scale). Data courtesy of Dr. Lapid-Gortzak. I have seen unhappy patients. Multifocal
IOLs significantly reduce contrast
One claimed incomplete satisfaction – highlighted the opportunity PanOptix™ sensitivity, because of splitting light,
despite having visual acuity above 20/20, offers to reinforce the concept of and patients may still need glasses for
he reported some shadows. Another increased spectacle independence intermediate tasks, such as computer
patient was dissatisfied because of after cataract surgery to patients, and work or seeing prices on supermarket
some residual refraction. “What I Dr. Lapid-Gortzak took the opportunity shelves. PanOptix™ could address most
found interesting was the incidence to reflect upon the lower glare and halo of these concerns.”
of halos. Not a single patient of mine perception of her patients, relative
spontaneously reported them.” When to that experienced by patients
asked, 70.6% said they saw none, 11.8% implanted with other trifocal IOLs.
said they saw them once in a while, Mayank Nanavaty, MD, a consultant “In essence, the
and only 17.6% reported that halos ophthalmic surgeon at Brighton and
were present. Sussex University Hospitals, United quadrifocal design is
Similarly, Bilgehan Sezgin Asena, MD, Kingdom, reinforced the point,
Head Physician, Ophthalmologist at noting that his PanOptix™-receiving modified so that
Kaskaloglu Eye Hospital, Izmir, Turkey, patients also experienced low rates
presented results that showed that, of dysphotopsia. the extended
out of 24 patients that were bilaterally
implanted with PanOptix™, after one- Selecting more patients intermediate focal
month follow-up, 18 reported that they The consensus amongst the surgeons
had never experienced glare or halos in was that PanOptix™ is suitable for point is
their daily lives, whereas only 6 patients a significant proportion of patients
experienced them “sometimes”. who desire spectacle independence. redistributed to the
Overall, Drs. Alfonso and Lapid- Dr. Sezgin Asena noted that
Gor tzak experienced predictable with PanOptix™, “Brain time for distance focal
outcomes, ver y good refractive patient selection in my practice has
and visual results, and excellent significantly decreased.” point for amplified
defocus curve results consistent with The Happy Patient Study included 183
a continuous range of vision, with patients implanted with a variety of non- performance.”
PanOptix™. Dr. Alfonso, in particular, toric multifocal IOLs (14), and although
S p o ns o r e d F e a tu r e  5

Compared with other presbyopia-


correcting IOLs…
There are a number of presbyopia-
correcting IOLs available on the 0.2
p=0.039

market today, each with unique optical 0.18


0.18 0.18 0.18 0.18 0.18

properties. In the absence of published 0.16


comparative, controlled clinical trials, 0.14
it’s hard to understand how these IOLs 0.12

LogMAR
perform against each other. Fortunately, 0.1
0.1

the surgeons perform many hundreds 0.08


of cataract procedures per month, and 0.06 0.05 0.05
have clinical experience with the most 0.04
implanted presbyopia-correcting IOLs: 0.02

PanOptix™, AT LISA tri, FineVision Tri 0


UDVA UIVA 60 UIVA 80 UNVA
and Tecnis Symfony.
PanOptix™ AT LISA tri

PanOptix™ and AT LISA tri


Martin Kacerovský, MD, Head Surgeon at
the Somich Eye Clinic in Prague, Czech
Republic, compared the six-month Figure 2. Uncorrected distance, intermediate (60 and 80 cm) and near LogMAR visual acuity.
visual acuity, photic outcomes and Statistically significant difference, p<0.05. UDVA: uncorrected distance visual acuity; UIVA: uncorrected
posterior capsule opacification (PCO) intermediate visual acuity; UNVA: uncorrected near visual acuity. Data courtesy of Dr. Kacerovský.
rates in patients who received bilateral
PanOptix™ implants (n=100; 200 Kacerovský reported that the mean value accuracy with PanOptix™, showing not
eyes) and AT LISA tri implants (n=100; of incidence of PCO in the AT LISA tri just a plano manifest spherical equivalent
200 eyes). All patients underwent group was 70%, with PCO occurring from one week to three months
femtosecond laser-assisted surgery with between 3–48 months after implantation postoperatively, but also very high
an Alcon LenSx ® system – and baseline and considering YAG laser procedure patient satisfaction rates. In comparison
demographic and refractive error was performed at 6-months post-op. with FineVision, Dr. Gundersen reported
similar in both groups. He concluded that both IOLs better near performance for PanOptix™
Uncorrected visual acuity at performed in a similar way (visual acuity, too, on top of being built in a well-known
distance, near (40 cm) and at two halos, glare and patient satisfaction), but AcrySof ® platform.
intermediate distances (60 and 80 cm) patients receiving PanOptix™ showed Further, Dr. Alfonso also presented
were assessed. It was similar for both superior visual acuity at 60 cm and three-month follow-up defocus curves
trifocal IOLs at distance, near and at required fewer Nd:YAG procedures than that showed a more continuous range of
80 cm (intermediate), but PanOptix™ those who received AT LISA tri. vision is achieved with PanOptix™ than
was significantly better (p=0.039) than with other trifocal IOLs (Figure 4).
AT LISA tri at 60 cm intermediate PanOptix™ and FineVision
distance (Figure 2). He noted that, Kjell Gunnar Gundersen, MD, Haugesund PanOptix™ and Symfony
“Halo and glare rates were similar for Medical Center, Norway, presented his Mike Holzer, MD, PhD, a professor at
both trifocal IOLs: ~70% of patients who own experience with PanOptix™ (32 the University Eye Clinic, Heidelberg,
received either lens experienced these patients) and FineVision (36 patients) Germany, presented results on 16
phenomena rarely or never.” trifocal IOLs after one year. Table 2 PanOptix™-implanted eyes (8 patients)
After six months, only one eye (0.5%) shows binocular decimal uncorrected with a follow-up of up to 3 months.
that received a PanOptix™ IOL required visual acuity at distance, intermediate All his procedures involved clear
Nd:YAG capsulotomy for PCO, whereas (60 cm for PanOptix™ and 80 cm for corneal incisions, femtosecond laser-
statistically significantly more eyes (n=12, FineVision) and near (40 cm) for both assisted surgery with LenSx ® and
6%, p=0.021) that received AT LISA tri evaluated IOLs. 5.0 mm capsulotomies. He also
required this procedure (Figure 3). Dr. He highlighted excellent refractive presented his early experience with the

www.alcon.com
6
 S p o ns o r e d F e a tu r e

the panelists were asked to comment


UDVA (± SD) UIVA (± SD) UNVA (± SD) how they felt the PanOptix™ and
ReSTOR® platforms compared.
PanOptix™ IOL 1.15 ± 0.16 1.09 ± 0.14 (at 60 cm) 1.07 ± 0.14 The panelists agreed that patients’
near vision with PanOptix™ was as
FineVision IOL 1.10 ± 0.10 0.99 ± 0.03 (at 80 cm) 1.01 ± 0.06 good as patients who received bifocal
lenses like ReSTOR® +3.0 – PanOptix™
provides intermediate vision, and this
Table 2. Decimal visual acuity outcomes six months follow-up after PanOptixTM and FineVision trifocal IOLs. meant that they preferred this option
UDVA: uncorrected distance visual acuity; UIVA: uncorrected intermediate visual acuity; UNVA: uncorrected over blended vision. Dominique Monnet,
near visual acuity. Data courtesy of Dr. Gundersen. MD, Head Ophthalmologist at Hospital
of Paris, France, and Ozana Moraru,
PanOptix™ showed a continuous range MD, Consultant Ophthalmologist at
of vision (0.1 LogMAR or better) from 0 Oculus Eye Clinic Bucharest, Romania,
p=0.021
14 to -3 D of range (from distance to 33 cm), concurred, with both reporting no
12 whereas Symfony achieved 0.1 LogMAR subjective complaints with PanOptix™
12
or better from 0 to 1.75 D (from distance versus mild subjective complaints with
10 to 57 cm). blended ReSTOR®. Islam Hamdi, MD,
8
Prof. Holzer also used questionnaires an Ophthalmology Consultant at the
to assess patients’ visual disturbances and Eye Consultants Center, Jeddah, Saudi
6 spectacle independence. To assess the Arabia, commented that PanOptix™
4 former, patients were asked to assign a ultimately limits the requirement to tailor
score (none, mild, moderate, noticeable, lenses for different cases or for mixing
2 1
severe) for day glare, night glare, painful/ and matching, as it’s well accepted by
0 burning eyes, halos, double images, vision both myopic and emmetropic patients.
YAG
problems under bright light, normal light, Similarly, in their practices, they agreed
PanOptix™ AT LISA tri
and dim/ low light conditions. Patients that most patients prefer trifocal over
who received PanOptix™ reported bifocal technology. Dr. Sezgin Asena
moderate halos and mild night glare – all explained “there are still some specific
Figure 3. Posterior capsule opacification cases after other evaluated parameters were ranked cases when you might choose ReSTOR®
six months that required Nd:YAG capsulotomy. lower than mild. By comparison, patients +2.5 over bilateral PanOptix™, for
Statistically significant difference, p<0.05. Data implanted with Symfony also reported example, in younger patients (especially
courtesy of Dr. Kacerovský. moderate halos and mild vision problems those who were previously emmetropic),
under low light conditions; other evaluated patients concerned by quality of vision
Symfony IOL at three-month follow-up parameters were lower than mild. In and still asking for additional range
in 13 patients bilaterally implanted with terms of spectacle independence, both of vision to that of a monofocal IOL,
the micro-monovision approach. PanOptix™ and Symfony-receiving patients and those with a distance-dominated
Binocular uncorrected visual acuity reported that they “never” needed glasses professional task, such as driving a
results for PanOptix™ were very for distance or intermediate vision – the commercial vehicle.”
satisfactory achieving values of 20/20 or difference between the IOLs arose with
better for distance, intermediate at 60 reading: on average, patients who received Maximizing outcomes with
cm and near at 40 cm. The Symfony IOL PanOptix™ reported “never” needing advanced technology equipment
showed similar visual performance for glasses, whereas patients who received “I believe that we are unanimous in our
distance and intermediate, but inferior Symfony reported that their need for opinion that PanOptix™ provides good
values for UNVA (40 cm) between spectacle use was either “sometimes” vision over all distances, but we need to
20/25 and 20/32 – these differences or “seldom.” apply a holistic approach to achieving the
were attributed to the differences in best possible outcome for our patients,
lens design. This effect was also observed Alcon Multifocal IOLs Portfolio and that means also selecting advanced
during the defocus curve evaluation – After their first PanOptix™ implantations, equipment to plan and perform the
S p o ns o r e d F e a tu r e  7

surgery,” says Ahmed Sedky, Chairman


and Consultant Ophthalmologist at the -0.2
100 66 50 40 33 cm
Eye Subspecialty Center in Cairo, Egypt. -0.1

Francesco Carones, MD, Carones 0

Ophthalmic Center, Milano, Italy, 0.1

explained that it’s essential that the


0.2

VA LogMAR
PanOptix
practice of cataract surgery is one
0.3

0.4

of a continual journey to improve 0.5


Fine

safety, accuracy and efficiency. Patients


Vision
0.6

understand and accept that as the 0.7 PanOptix™ (n=20 / 3 m) AT LISA tri
technology evolves, there will be fewer 0.8 FineVision (n=20 / 3 m)

complications and more eyes closer to 0.9 AT LISA tri (n=20 / 3 m)

the refractive target – and that modern 1.0


2.0 1.5 1.0 0.5 0.0 -0.5 -1.0 -1.5 -2.0 -2.5 -3.0 -3.5 -4.0 -4.5 -5.0

instruments like LenSx ® and Verion™ Defocus (D)


may help the surgeon to perform a better
procedure. The instruments aid surgeons’
efficiency too – integrated systems Figure 4. Binocular defocus curve after three-month follow-up for PanOptixTM, FineVision and AT LISA tri
streamline the surgical process from IOLs. Data courtesy of Dr. Alfonso.
biometry onwards, and should minimize
inter-individual differences. These are
important – modern technology is not Preoperative
without cost, and the surgeon needs to (Standard values utilized Intraoperative Postoperative
see a return on their investment. when planning pre-op
Dr. Carones presented a case
series of 60 patients of his (120 SIA: 0.28 D for OD, 0.09 D
LenSx ® Digital marker
eyes; axial length 22.0 –24.5 mm, for OS for toric IOLs Data feedback and
with preoperative corneal astigmatism SRK-T A-constant surgical factors update
>1.00 D) who received either the Digital marker at the (SIA and A-constant)
optimization: 119.46 for
AcrySof ® IQ toric or AcrySof ® ReSTOR® microscope
ReSTOR® +2.5
toric IOL. The patients were split into
three groups (20 patients, 40 eyes per
group): standard phacoemulsification Table 3. How VerionTM helped provide an efficient data feedback and workflow loop for Dr. Carones in a
(2.0 mm temporal incision, bimanual case series of 60 patients with corneal astigmatism >1.0 D who received AcrySof® IQ toric or AcrySof®
irrigation/aspiration and manual ReSTOR® Toric IOLs. SIA: surgically induced astigmatism.
marking); femtosecond laser-assisted
cataract surgery (FLACS; as above, IOLs, the minimization of postoperative precise in size and shape than those
manual marking, but with LenSx ® rotation is crucial with these lenses to created manually. One historical concern
capsulotomy), and FLACS plus Verion™ ensure the best possible outcomes. with femtosecond lasers was that they
for all phases. What he found was that Femtosecond lasers promise precise had been thought to induce greater levels
Verion™ helped provide an efficient data and reproducible capsulotomies. But are of cell death in the surrounding tissue
feedback and workflow loop (Table 3) – they that much more precise than can be than manual capsulorhexes, but Prof.
and significantly better refractive results, achieved by hand? Kohnen highlighted the work of Mayer
with less residual cylinder and lower axis According to Prof. Kohnen, yes. He et al. (16), which demonstrated that a
rotation (Figure 5). presented the results of a prospective, laser pulse energy of 5 µJ, delivered via
It’s long been known that a precise randomized comparison of FLACS a curved interface and a soft contact
capsulotomy is essential for the successful capsulotomy versus manual capsulorhexis lens-fitted femtosecond laser system
implantation of premium IOLs – proper that involved 39 patients (15). What (in this case, Alcon’s LenSx ®) resulted in
centration, and the correct effective lens was found was that the laser-created cell death levels that were comparable to
position (ELP), and particularly with toric capsulotomies were significantly more those seen with manual capsulorhexes.

www.alcon.com
8
 S p o ns o r e d F e a tu r e

Cataract Refract Surg, 41, 2330–2332 (2015).


PMID: 26703312.
3. PanOptix™ Diffractive Optical Design. Alcon
internal technical report: TDOC-0018723.
Effective date: 19 Dec 2014.
4. N Charness et al., “Monitor viewing distance
for younger and older workers”. Proceedings of
the Human Factors and Ergonomics. Available
at: bit.ly/MVDyoung. Accessed July 22, 2016.
5. Average of American OSHA, Canadian OSHA and
American Optometric Association
Recommendations for Computer Monitor Distances.
6. Alcon Laboratory Notebook, 14073, 77–78.
7. S Lee et al., “Optical bench performance of a
novel trifocal intraocular lens compared with a
multifocal intraocular lens”, Clin Ophthalmol,
10, 1031–1038 (2016). PMID: 27330273.
8. JT Schwiegerling, “Diffractive trifocal lens”.
Patent: US9320594 B2. Publication date: April
Figure 5. Proportion of patients meeting the target parameter who underwent manual cataract surgery, 26, 2016. Available at: bit.ly/Trifocal. Last
FLACS, or FLACS plus Verion™ surgery. FLACS, femtosecond laser-assisted cataract surgery. SE, spherical accessed August 15, 2016.
equivalent. *Statistically significant differences (p<0.05). Data courtesy of Dr. Carones. 9. M-T Choi, X Hong, Y Liu, “Multifocal diffractive
ophthalmic lens using suppressed diffractive
Best practice should bring the best IOL implantation by optimizing accuracy order”. Patent US20150331253 A1. Publication
possible end result, though. Joaquim and patient outcomes, while decreasing date: Nov 19, 2015. Available at: http://bit.ly/
Mur ta, MD, PhD, Director of the potential enhancement rate.” PanOptix. Last accessed August 15, 2016.
Ophthalmology Service, Coimbra Ultimately, patients who undergo 10. D Gatinel et al., “Design and qualification of
Hospital and University Centre, Portugal, refractive cataract surgery expect adiffractive trifocal optical profile for
gave an example of how he uses the excellent outcomes. Part of this comes intraocularlenses”, J Cataract Refract Surg, 37,
Alcon cataract refractive suite to optimize down to diligent assessment of patients’ 2060–2067 (2011). PMID: 22018368.
outcomes (Verion™ and LenSx ®). He needs and expectations after surgery, 11. ZEISS AT LISA® IOL Sales Brochure.
spoke of his use of the microscope- and making the most appropriate 12. AcrySof® IQ PanOptix™ IOL Directions
mounted intraoperative aberrometry choice together with them. The other for Use.
with ORA™ – the Optiwave® Refractive part comes down to the pursuit of 13. Optical performance of the hybrid RESTOR
Analysis device (which can be adapted excellence and precision, and according distance dominant (DD) 2.5 D IOL. TDOC:
to all kinds of operating microscopes). to all meeting participants, it’s this 005215. Effective date: April 11, 2016.
ORA™ measures refraction during that should be consistently achievable 14. U Mester et al., “Impact of personality
surgery, giving the surgeon intraoperative with products like PanOptix™, the characteristics on patient satisfaction after
information about axis and magnitude Verion™ Image Guided System, LenSx ® multifocal intraocular lens implantation: results
of astigmatism, plus IOL selection and and ORA™. from the ‘happy patient study’”, J Refract Surg,
placement. He reported that it helps 30, 674–678 (2014). PMID: 25291750.
guide IOL placement, and verify the right References 15. N Friedman et al., “Femtosecond laser
IOL choice has been made, as different 1. R Montés-Micó et al., “Visual performance capsulotomy”, J Cataract Refract Surg, 37,
devices in the market give slightly with multifocal intraocular lenses: mesopic 1189–1198 (2011). PMID: 21700099.
different keratometric values, ORA™ contrast sensitivity under distance and near 16. WJ Mayer et al., “Cell death and
can adjust the results intra-operatively. conditions”, Ophthalmology, 111, 85–96 ultrastructural morphology of femtosecond
Prof. Murta noted that “ORA™ that is (2004). PMID: 14711718. laser-assisted anterior capsulotomy”, Invest
not only helpful in patients with prior 2. T Kohnen., “First implantation of a diffractive Ophthalmol Vis Sci, 55, 893–898 (2014).
refractive surgery but also in premium quadrafocal (trifocal) intraocular lens”, J PMID: 24408981.

You might also like