Mortality, Survival and Risk Factors. Clin Colon Rectal Surgery.2009. 22:191– 7 2. WHO. 2015. Cancer. ([Online] diakses tanggal 31 Desember 2017 melalui http://www.who.int/mediacentre/factsheets/fs297/en/) 3. American Cancer Society. 2017. Colorectal Cancer. ACS ([Online] diakses tanggal 10 Juli 2017 melalui www.cancer.org) 4. Departemen Kesehatan Republik Indonesia. 2009. Profil kesehatan Indonesia 2008. Pusat Data & Informasi Departemen Kesehatan Republik Indonesia. 5. Ferlay J, Soerjomataram I, Dikshit R. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015; 136: E359–E386. 6. Newton, S. 2009. Oncology nursing advisor comprehensive guide to clinical practice. St. Louis: Mosby 7. Judarwanto, W. 2008. ”Panduan Pemberian Buah dan Sayuran pada Anak”,(online)available:[http://www.sehatgroup.web.id/artikel1415] 8. Scalbert A, Williamson G. Dietary intake and bioavailability of polyphenols. J Nurt 2000. 130:2073S-85S 9. Othman, A., Ismail, A., Ghani, N.A., Adenan, I. Antioxidant Capacity and Phenolic Content of Cocoa Bean. Food Chemistry 2007,1523-30. 10. Weisburger, J. H. Chemopreventive Effects of Cocoa Polyphenols on Chronic Diseases. Experimental Biology and Medicine 2001, 226: 891-7. 11. Keen, C. L., Holt, R.R., Oteiza, P., Fraga, C., and Schmitz, H.H. Cocoa Antioxidant and Cardio vascular Health. Am. J. Clin. Nutrition 2005, 81(1): 298S-303S. 12. Lee, K.W., Kim,Y.J., Lee, H.J., Lee, C.Y. Cocoa has More Phenolic Phytochemical and Higher Antioxidant Capacity than Teas and Red Wine. J.Agric. Food. Chem 2003, 51(25) : 7292- 95 13. Figueira, A., and Janick, J. New products from Theobroma cacao: Seed pulp and pod gum. New crops., New York 1993, 475- 8 14. Irma, N., 2014. Kandungan Polifenol Serta Potensi Kulit Buah dan Salut Biji Kakao (Theobroma cacao L.) Sebagai Antioksidan. Yogyakarta: UGM 15. Klaenhammer TR, Kleerebezem M, Kopp MV, Rescigno M. The impact of probiotics and prebiotics on the immune system. Nat Rev Immunol. 2012;12(10):728–4 16. Olejnik, A., Tomczyk, J., Kowalska, K. & Grajek, W. The role of natural dietary compounds in colorectal cancer chemoprevention. Postepy Hig Med Dosw 2010 (Online) 64, 175–187 17. Hermana, I., Kusmawarti, A., Indriati, N. Mikroenkapsulasi Strain Probiotik Leuconostoc mesenteroides ssp. cremonis BN12 Menggunakan Berbagai Penyalut. JPB Kelautan dan Perikanan Vol. 10 No. 2 Tahun 2015: 133-141 18. Harnisya Nasution. 2016. Karakterisasi Mikrokapsul Sinbiotik Bakteri Asam Laktat Isolat PG7 yang Dienkapsulasi dengan Alginat, Susu Skim dan Inulin. Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sumatera Utara. Medan 19. Wise DL. (2000). Handbook of pharmaceutical controlled release Technology. [serial on the internet]. [Diakses tanggal 28 juli 2010]. Avaiable from : http:/www.pharmatext.org 20. International Agency for Research on Cancer (IARC) / WHO. (2012). GLOBOCAN 2012: Estimated cancer incidence, mortality, and prevalence worldwide in 2012. Diakses melalui http://globocan.iarc.fr/Pages/ fact_sheets_population.aspx pada tanggal 26 Desember 2017. 21. Murdani Abdullah, dkk. Molecular profile of colorectal cancer in Indonesia: is there another pathway?. Gastroenterol Hepatol Bed Bench. 2012. 5(2) : 71-78 22. WHO. 2014. Cancer Country Profiles: Section Indonesia. Diakses melalui http://www.w ho.int/cancer/country-profiles/idn_en.pdf pada tanggal 26 Desember 2017. 23. Liu, M., F. H. J. v. Enckevort, and R. J. Siezen. Genome update: lactic acid bacteria genome sequencing is booming. MicrobioL. 2005. 151: 3811-3814 24. Anonim. Gambar Lactobacillus bulgaricus diakses pada 27 Desember 2017 melalui https://probioticsamerica.com/lactobacillus-bulgaricus 25. Anonim. Gambar Streptococcus thermophilus diakses pada 27 Desember 2017 melalui https://probioticsamerica.com/streptococcus-thermophilus/ 26. Anonim. Gambar Bifidobacterium diakses pada 27 Desember 2017 melalui https://microbewiki.kenyon.edu/index.php/The_role_of_Bifidobacterium_on_th e_Immune_System 27. Salazar-Lindo, E., D. Figueroa-Quintanilla, M. I. Caciano, V. Reto-Valiente, G. Chauviere, and P. Colin. Effectiveness and Safety of Lactobacillus LB in the Treatment of Mild Acute Diarrhea in Children. J. Ped. Gastroenterol. Nutr. 2007. 4 (4) :571-576. 28. Isolauri, E. and S. Salminen. Probiotics: Use in Allergic Disorders: a Nutrition, Allergy, Mucosal Immunology, and Intestinal Microbiota (NAMI) Research Group Report. J. Clin. Gastroenterol. 2008. 42 (2) : 91 – 96. 29. Lee, J., Y. Kim, H. S. Yun, J. G. Kim, S. Oh, and S. H. Kim. Genetic and Proteomic Analysis of Factors Affecting Serum Cholesterol Reduction by Lactobacillus acidophilus A4. Appl. Environ. Microbiol. 2010. 76(14): 4829- 4835. 30. Liong, M.T. Roles of Probiotics and Prebiotics in Colon Cancer Prevention: Postulated Mechanisms and In-vivo Evidence. Int. J. Mol. Sci. 2008. 9 (5) : 854- 863. 31. Li Zhong, Xufei Zhang, Mihai Covasa. Emerging roles of lactic acid bacteria in protection against colorectal cancer. World J Gastroenterol. 2014. 20 (24): 7878- 7886 32. Wahyudi, T., T.R, Pangabean., dan Pujianto. 2008. Panduan Lengkap Kakao Manajemen Agribisnis dari Hulu hingga Hilir. Penebar Swadaya. Jakarta. 33. Anonim. Gambar Buah Kakao diakses pada 27 Desember 2017 melalui http://www.sumbarprov.go.id/details/news/9171 34. Sartini, Djide MN, Alam G. Ekstraksi komponen bioaktif dari limbah kulit buah kakao dan pengaruhnya terhadap aktivitas antioksidan dan antimikroba. 2007. Farmasi UNHAS 35. Rohmatussolihat. (2009). Antioksidan, Penyelamat Sel-Sel Tubuh Manusia. BioTrends, 4(1). 36. Sayuti K, Yenrina R. 2015. Antioksidan Alami dan Sintetik. Andalas University Press: Padang 37. Chaerrunisaa. Y. (2004) . Mikrokapsul : metode penyalutan dan evaluasi farmasetiknya. Semarang : Pustaka Rizki Putra 38. Ankit, K. dkk. (2011). Microencapsulation As A Novel Drug Deliverry Syste. International Pharmaceutica Sciencia.Vol 1. 39. Dziezak D. J. (1988). Microencapsulation and Encapsulated Ingredients. Food Tecnology, 136-138. 40. Jong D. 2013. Buku Ajar Ilmu Bedah. In: Riwanto Ignatius, Hamami AH, Pieter John, Tjambolang Tadjuddin Ahmadsyah Ibrahim. Usus Halus, Appendiks, Kolon, dan Anorektum. Jakarta: EGC 41. Anita Kurniawati RT. Pengaruh Asam Asetil Salisilat terhadap Penurunan Prevalensi Kanker Kolorektal. Cermin Dunia Kedokteran 2011;38 42. Kumar C, Robbins. Buku Ajar Patologi Volume 2. In: Crawford James M, Kumar Vinay. Rongga Mulut dan Saluran Gastrointestinal. 7th ed. Jakarta: EGC, 2007. 609-62 43. Parish B, Ign. Riwanto, A. Maleachi, Kunsemedi S. Report Incidence of Colorectal Cancer in Dr. Kariadi General Hospital Semarang 2009 - 2010. 1st Makassar Colorectal Cancer Conference: 2011 Jun 2-4 44. IKABDI. Panduan penatalaksanaan kanker kolorektal 2014. 45. Chao A, Thun MJ, Connell CJ, McCullough ML, Jacobs EJ, Flanders WD, et al. Meat consumption and risk of colorectal cancer. JAMA. 2005; 293: 172-82. 46. Dagfi nn A, Doris C, Rosa L, Rui V, Darren G. Dietary fi bre, whole grains, and risk of colorectal cancer: Systematic review and dose-response meta- analysis of prospective studies. BMJ. 2011; 343. doi: http://dx.doi.org/10.1136/bmj.d6617. 47. Kusumawardani, N. Penanganan Nutrisi Pada Penderita Kanker. Media Litbangkea 1996 Vol. VI No.04 48. Suryani, Dinie & Zulfebriansyah. Komoditas Kakao: Potret dan Peluang Pembiayaan di dalam Economic Review 2007 No.210. pp.1 49. Susanti, A. Outlook Komoditi Kakao . Pusat Data dan Sistem Informasi Pertanian Sekretari Jenderal Kementrian Pertanian 2014. 50. Karim, A. A., Azlan, A., Ismail, A., Hashim, P., Gani, S. S. A., Zainuddin, D. H., Abdullah, N. A. Phenolic composition, antioxidant, ati-wrinkles and tyrosinase inhibitory activities of cocoa pod extract. BMC Complementary and Alternative Medicinen 2014, 14:381 51. Zhu L, Zuo Z, Chow MS. Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use. J Clin Pharmacol 2013;45(12):1345-59. 52. Murtaza, G, M Ahmad and G Shahnaz. Microencapsulation of Diclofenac Sodium by Nonsolvent Addition Technique. Tropical Journal of Pharmaceutical Research April 2010; 9 (2): 187-195. 53. , S, T. D. Durance a; R. Wang B. Effect of alginate-pectin composition on drug release characteristics of microcapsules. Journal of Microencapsulation 2009. Canada