OCCURRENCE OF SQUAMOUS CELL CARCINOMA IN NO)
DESCRIPT DOG
Mahesh. S. Bhandurge!, Sahu Rajesh Kumar, G. Ramesh Naik, T. Usha, G.K. Sawale,
Y. Ravikumar, D, Madhur? and M. Lakshman
'MAVSe, Student, 2Professor & Head, Department of Veterinary Pathology, College of Veterinary Science,
PVNRT Veterinary University, Rajendranagar, Hyderabad - 500 030 (Telangana),
[Received: 13.1.2017; Accepted: 19.9.2017]
AA nine years old nondescript male dog was treated atthe Private Pet Clinic growth on the upper surface of
eyelid. The growth was surgically removed. However, after 3 month of the surgery, again another growth appeared on
skin near base of tal, The growth was removed and submitted for histopathological examination to our pathology
department which revealed characteristics lesions of squamous cell carcinoma,
Key words: Histopathology, Non-descript dog, Squamous cell carcinoma.
Squamous cell carcinoma (SCC) is a
malignant neoplasm arising from squamous
epithelium. In dogs, SCC accounts for
approximately 5% of cutaneous neoplasms.
The most common cutaneous locations for
SCC in the dog are the skin, oral cavity, nail
bed, scrotum, legs, and various lightly
pigmented areas (Goldschmidt and Hendsick,
2002; Withrow and Vail, 2007). Other
locations reported to develop SCC in dogs
include the conjunctiva, cornea, nasal
passages, larynx, lung, esophagus, bladder,
prostate, penis, cervix, vagina, and anal sac
(Esplin et af. 2003). Present communication
describe occurrence of SCC on the surface of
eyelid and tail in a nine year old non-descript
dog,
Case History and Observations
‘A nine years old non-descript male
dog was presented to the Private Pet Clinic
with small nodular growth on the upper
surface of eyelid which tumed to somewhat
cauliflower like structure after 15 days. It was
removed surgically. However, after 3 month
of the surgery again another nodular
cauliflower like growth of 1.5 em in diameter
appeared on skin near base of tal
The growth was surgically excised
and preserved in the 10% buffered formalin
solution. The tissues were submitted to the
Departmentof Pathology, COVAS,
Hyderabad for Histopathology. The fixed
tissue samples were processed by paraffin
embedding technique. Sections of 5 ym thick
Indian Journal of Canine Practice
were taken and stained with hematoxylin and
eosin (H&E) method,
Results and Discussion
The growths were confirmed as SCC
by histopathological examination, ‘The
tumour showed rapid growth and metastas
with growth on skin at the hase of tail. In
ferature, the most cases of SCs are locally
invasive and in certain areas of the body,
exhibit bone invasion and osteolysis. Tumour
spread to local lymph nodes may occur, but
distant metastases are rare and usually do not
‘occur until late in the disease process as also
reported by Goldschmidt and Hendrick
(2002) and Withrow and Vail (2007).
The age of dog in the present
investigation was 9 year. In accordance to this
Goldschmidt and Hendrick (2002) were also
of the opinion that older dogs are at greater
risk for developing SCC, with the average age
of presentation being 8 to 10 years. Prolonged
exposure to UV light, lack of skin pigment
and a sparse hair coat all have been suggested
for the development of cutaneous SCC.
Histopathological examination of ocular
growth showed characteristic lesions of well
differentiated SCC. The neoplastic cells
showed a wide range of maturation ranging
from small immature type to highly
keratinized cells with the number of latter
being predominant, The section showed
extensive keratinization with formation of
keratin “pearls” (Fig.l). The histological
appearance was similar to that previously
186 Volume 9 Issue 2, December, 2017described by Chandrashekaraiah, e¢ al. (2011)
Fig.l: Section of skin from
Conclusions
SCC is typically a locally aggressive
neoplasm with a variable potential for distant
metastasis. SCC is a common tumour of dogs
that vary in appearance, location, and biologic
behavior; however, they are typically locally
aggressive, with a reported low to moderate
metastatic potential. Hence, early recognition,
diagnosis and treatment are essential,
References
Chandrashekaraiah, G.B., Rao, Suguna,
Munivenkatappa, B.S. and Mathur, K.Y.
(2011), Canine Squamous Cell
Careinoma: a Review of 17 Cases. Braz.
J. Vet. Pathol.,A(2): 79-86.
Das, J., Behera, S.S., Panda, $.K. and Behera,
M, (2015). Ocular squamous cell
Indian Journal of Canine Practice
and Das etal. (2015).
keratinization with keratin pearls (H& E, 40x)
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Esplin, D.G., Wilson, R.S. and Hullinger,
GA. (2003). Squamous cell carcinoma of
the anal sac in five dogs. Vet. Pathol, 40:
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Goldschmidt, M.H. and Hendrick, MJ
(2002). Tumors of the skin and soft
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187 Volume 9 Issue 2, December, 2017
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