Professional Documents
Culture Documents
My Hypothesis:
● OIT is an effective solution as past, current, and future
prospects
Past Discoveries
● Achieve Desentization - Many children were able to
consume more of the antigen without reacting
● However, the allergy did return if the antigen was not
reintroduced periodically.
● Is successful in different food antigens, especially in
peanuts, milk, and eggs
Current Studies
● Needs to transition into clinical setting rather than labs
○ Improve efficiency and effectivity by modifying the
procedures.
○ Set procedures in order to guarantee results
● Ensure safety above all else
● Use of supplemental medications to reduce reactions
○ Omalizumab, reduces IgE in the immune system
Future Studies
● Perfect the treatment in order to find the mechanism
● Achieve complete tolerance- the allergy is
permanently cured, the patient can eat any amount of
antigen
● Assessing long term effects
Data Collection
My Questions:
● Do clinical studies show that OIT is effective and ethical?
● What aspects of the procedures differ and what is similar?
● How do the results differ?
● Is there a correlation between the result and procedures?
What did I do?
● Compared 3 different peanut OIT studies
● Observed eligibility, updosing, placebo, drop out rates and
homedosing
● Examined the purpose of each study
So to Summarize...
● Eligibility- personal safety in attempting OIT
● Updosing- the treatment’s efficiency and patient safety
● Placebo- the accuracy and validity of the studies
● Drop out rate- the individual risk of the treatment
● Homedosing-the efficiency and efficacy of OIT
Conclusion
● Data collection supported my research paper
● Both find that OIT is an effective and ethical treatment
● However, there are still many holes in the treatment, so
it is not ready for public use.
My Experience
Evolution of Research
● Started with the cause of allergies: how are they formed
● Moved into why are there more people with allergies
● Looked at food allergies in particular
● Then looked at treatments
● Then looked at immunotherapy
● Ended at oral immunotherapy
Evolution of Research
● Started at what is OIT
● Moved into what are the methods
and results
● Then looked at efficacy and
ethicacy
● Looked at different studies for
consistency
● Still continuing to look at studies
for comparisons
What I learned?
● It's a long process- Don’t rush things!
● You will NOT get results you expect
● Don’t be afraid to change your goals and focus
● It is about the journey not the destination!
Questions?