Dissociative Disorders

In psychiatry, dissociation is de ned as an unconscious defense mechanism involving the segregation of any group of mental or behavioral
processes from the rest of the person’s psychic activity. Dissociative disorders involve this mechanism so that there is a disruption in one or
more mental functions, such as memory, identity, perception, consciousness, or motor behavior. The disturbance may be sudden or gradual,
transient or chronic, and the signs and symptoms of the disorder are often caused by psychological trauma.

Amnesia brought on by intrapsychic con ict is coded di erently from amnesia brought on by a medical condition such as encephalitis. In the latter case, according to the fth
edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), a diagnosis of neurocognitive disorder due to a medical condition would be made; whereas in the former
condition, a diagnosis of dissociative amnesia would be made. (See Section 21.4 which discusses neurocognitive disorders brought on by another medical condition [amnestic
disorder] for a further discussion of this topic.)

DISSOCIATIVE AMNESIA
The DSM-5 diagnostic criteria for dissociative amnesia are listed in Table 12-1. The main feature of dissociative amnesia is an inability to
recall important personal information, usually of a traumatic or stressful nature, that is too extensive to be explained by normal
forgetfulness. And, as mentioned above, the disorder does not result from the direct physiological e ects of a substance or a neurological or
other general medical condition. The different types of dissociative amnesia are listed in Table 12-2.

Table 12-1
DSM-5 Diagnostic Criteria for Dissociative Amnesia

Table 12-2
Types of Dissociative Amnesia

A 45-year-old, divorced, left-handed, male bus dispatcher was seen in psychiatric consultation on a medical unit. He had been admitted
with an episode of chest discomfort, light-headedness, and left-arm weakness. He had a history of hypertension and had a medical
admission in the past year for ischemic chest pain, although he had not su ered a myocardial infarction. Psychiatric consultation was
called, because the patient complained of memory loss for the previous 12 years, behaving and responding to the environment as if it
were 12 years previously (e.g., he did not recognize his 8-year-old son, insisted that he was unmarried, and denied recollection of current
events, such as the name of the current president). Physical and laboratory ndings were unchanged from the patient’s usual baseline.
 Brain computed tomography (CT) scan was normal.
On mental status examination, the patient displayed intact intellectual function but insisted that the date was 12 years earlier, denying
recall of his entire subsequent personal history and of current events for the past 12 years. He was perplexed by the contradiction
between his memory and current circumstances. The patient described a family history of brutal beatings and physical discipline. He was
a decorated combat veteran, although he described amnestic episodes for some of his combat experiences. In the military, he had been a
champion golden glove boxer noted for his powerful left hand.
He was educated about his disorder and given the suggestion that his memory could return as he could tolerate it, perhaps overnight
during sleep or perhaps over a longer time. If this strategy was unsuccessful, hypnosis or an amobarbital (Amytal) interview was
proposed. (Adapted from a case of Richard J. Loewenstein, M.D., and Frank W. Putnam, M.D.)

Epidemiology
Dissociative amnesia has been reported in a range of approximately 2 to 6 percent of the general population. No known di erence is seen
in incidence between men and women. Cases generally begin to be reported in late adolescence and adulthood. Dissociative amnesia can be
especially difficult to assess in preadolescent children because of their more limited ability to describe subjective experience.

Etiology
In many cases of acute dissociative amnesia, the psychosocial environment out of which the amnesia develops is massively con ictual, with
the patient experiencing intolerable emotions of shame, guilt, despair, rage, and desperation. These usually result from con icts over
unacceptable urges or impulses, such as intense sexual, suicidal, or violent compulsions. Traumatic experiences such as physical or sexual
abuse can induce the disorder. In some cases the trauma is caused by a betrayal by a trusted, needed other (betrayal trauma). This betrayal is
thought to influence the way in which the event is processed and remembered.

Diagnosis and Clinical Features

Classic Presentation. The classic disorder is an overt, florid, dramatic clinical disturbance that frequently results in the patient being
brought quickly to medical attention, specifically for symptoms related to the dissociative disorder. It is frequently found in those who have
experienced extreme acute trauma. It also commonly develops, however, in the context of profound intrapsychic conflict or emotional stress.
Patients may present with intercurrent somatoform or conversion symptoms, alterations in consciousness, depersonalization, derealization,
trance states, spontaneous age regression, and even ongoing anterograde dissociative amnesia. Depression and suicidal ideation are reported
in many cases. No single personality profile or antecedent history is consistently reported in these patients, although a prior personal or
family history of somatoform or dissociative symptoms has been shown to predispose individuals to develop acute amnesia during traumatic
circumstances. Many of these patients have histories of prior adult or childhood abuse or trauma. In wartime cases, as in other forms of
combat-related posttraumatic disorders, the most important variable in the development of dissociative symptoms, however, appears to be
the intensity of combat. Table 12-3 presents the mental status evaluation of dissociative amnesia.

Table 12-3
Mental Status Examination Questions for Dissociative Amnesia

Nonclassic Presentation. These patients frequently come to treatment for a variety of symptoms, such as depression or mood
swings, substance abuse, sleep disturbances, somatoform symptoms, anxiety and panic, suicidal or self-mutilating impulses and acts, violent
outbursts, eating problems, and interpersonal problems. Self-mutilation and violent behavior in these patients may also be accompanied by
amnesia. Amnesia may also occur for flashbacks or behavioral re-experiencing episodes related to trauma.
Differential Diagnosis
The differential diagnosis of dissociative amnesia is listed in Table 12-4.

Table 12-4
Differential Diagnosis of Dissociative Amnesia

Ordinary Forgetfulness and Nonpathological Amnesia. Ordinary forgetfulness is a phenomenon that is benign and unrelated
to stressful events. In dissociative amnesia, the memory loss is more extensive than in nonpathological amnesia. Other nonpathological forms
of amnesia have been described, such as infantile and childhood amnesia, amnesia for sleep and dreaming, and hypnotic amnesia.

Dementia, Delirium, and Amnestic Disorders due to Medical Conditions. In patients with dementia, delirium, and
amnestic disorders due to medical conditions, the memory loss for personal information is embedded in a far more extensive set of
cognitive, language, attentional, behavioral, and memory problems. Loss of memory for personal identity is usually not found without
evidence of a marked disturbance in many domains of cognitive function. Causes of organic amnestic disorders include Korsakoff’s psychosis,
cerebral vascular accident (CVA), postoperative amnesia, postinfectious amnesia, anoxic amnesia, and transient global amnesia.
Electroconvulsive therapy (ECT) may also cause a marked temporary amnesia, as well as persistent memory problems in some cases. Here,
however, memory loss for autobiographical experience is unrelated to traumatic or overwhelming experiences and seems to involve many
different types of personal experiences, most commonly those occurring just before or during the ECT treatments.

Posttraumatic Amnesia. In posttraumatic amnesia caused by brain injury, a history of a clear-cut physical trauma, a period of
unconsciousness or amnesia, or both is usually seen, and there is objective clinical evidence of brain injury.

Seizure Disorders. In most seizure cases, the clinical presentation differs significantly from that of dissociative amnesia, with clear-cut
ictal events and sequelae. Patients with pseudoepileptic seizures may also have dissociative symptoms, such as amnesia and an antecedent
history of psychological trauma. Rarely, patients with recurrent, complex partial seizures present with ongoing bizarre behavior, memory
problems, irritability, or violence, leading to a differential diagnostic puzzle. In some of these cases, the diagnosis can be clarified only by
telemetry or ambulatory electroencephalographic (EEG) monitoring.

Substance-Related Amnesia. A variety of substances and intoxicants have been implicated in the production of amnesia. Common
offending agents are listed in Table 12-4.

Transient Global Amnesia. Transient global amnesia can be mistaken for a dissociative amnesia, especially because stressful life
events may precede either disorder. In transient global amnesia, however, there is the sudden onset of complete anterograde amnesia and
learning abilities; pronounced retrograde amnesia; preservation of memory for personal identity; anxious awareness of memory loss with
repeated, often perseverative, questioning; overall normal behavior; lack of gross neurological abnormalities in most cases; and rapid return
of baseline cognitive function, with a persistent short retrograde amnesia. The patient usually is older than 50 years of age and shows risk
factors for cerebrovascular disease, although epilepsy and migraine have been etiologically implicated in some cases.

Dissociative Identity Disorders. Patients with dissociative identity disorder can present with acute forms of amnesia and fugue
episodes. These patients, however, are characterized by a plethora of symptoms, only some of which are usually found in patients with
dissociative amnesia. With respect to amnesia, most patients with dissociative identity disorder and those with dissociative disorder not
otherwise specified with dissociative identity disorder features report multiple forms of complex amnesia, including recurrent blackouts,
fugues, unexplained possessions, and fluctuations in skills, habits, and knowledge.

Acute Stress Disorder, Posttraumatic Stress Disorder, and Somatic Symptom Disorder. Most forms of dissociative
amnesia are best conceptualized as part of a group of trauma spectrum disorders that includes acute stress disorder, posttraumatic stress
disorder (PTSD), and somatic symptom disorder. Many patients with dissociative amnesia meet full or partial diagnostic criteria for those
acute stress disorders or a combination of the three. Amnesia is a criterion symptom of each of the latter disorders.

Malingering and Factitious Amnesia. No absolute way exists to differentiate dissociative amnesia from factitious or malingered
amnesia. Malingerers have been noted to continue their deception even during hypnotically or barbiturate-facilitated interviews. A patient
who presents to psychiatric attention seeking to recover repressed memories as a chief complaint most likely has a factitious disorder or has
been subject to suggestive influences. Most of these individuals actually do not describe bona fide amnesia when carefully questioned, but
are often insistent that they must have been abused in childhood to explain their unhappiness or life dysfunction.

Course and Prognosis

Little is known about the clinical course of dissociative amnesia. Acute dissociative amnesia frequently spontaneously resolves once the
person is removed to safety from traumatic or overwhelming circumstances. At the other extreme, some patients do develop chronic forms
of generalized, continuous, or severe localized amnesia and are profoundly disabled and require high levels of social support, such as
nursing home placement or intensive family caretaking. Clinicians should try to restore patients’ lost memories to consciousness as soon as
possible; otherwise, the repressed memory may form a nucleus in the unconscious mind around which future amnestic episodes may
develop.

Treatment
Cognitive Therapy. Cognitive therapy may have specific benefits for individuals with trauma disorders. Identifying the specific
cognitive distortions that are based in the trauma may provide an entrée into autobiographical memory for which the patient experiences
amnesia. As the patient becomes able to correct cognitive distortions, particularly about the meaning of prior trauma, more detailed recall of
traumatic events may occur.

Hypnosis. Hypnosis can be used in a number of different ways in the treatment of dissociative amnesia. In particular, hypnotic
interventions can be used to contain, modulate, and titrate the intensity of symptoms; to facilitate controlled recall of dissociated memories;
to provide support and ego strengthening for the patient; and, finally, to promote working through and integration of dissociated material.
In addition, the patient can be taught self-hypnosis to apply containment and calming techniques in his or her everyday life. Successful use
of containment techniques, whether hypnotically facilitated or not, also increases the patient’s sense that he or she can more e ectively be in
control of alternations between intrusive symptoms and amnesia.

Somatic Therapies. No known pharmacotherapy exists for dissociative amnesia other than pharmacologically facilitated interviews. A
variety of agents have been used for this purpose, including sodium amobarbital, thiopental (Pentothal), oral benzodiazepines, and
amphetamines.
Pharmacologically facilitated interviews using intravenous amobarbital or diazepam (Valium) are used primarily in working with acute
amnesias and conversion reactions, among other indications, in general hospital medical and psychiatric services. This procedure is also
occasionally useful in refractory cases of chronic dissociative amnesia when patients are unresponsive to other interventions. The material
uncovered in a pharmacologically facilitated interview needs to be processed by the patient in his or her usual conscious state.

Group Psychotherapy. Time-limited and longer-term group psychotherapies have been reported to be helpful for combat veterans
with PTSD and for survivors of childhood abuse. During group sessions, patients may recover memories for which they have had amnesia.
Supportive interventions by the group members or the group therapist, or both, may facilitate integration and mastery of the dissociated
material.

DEPERSONALIZATION/DEREALIZATION DISORDER
Depersonalization is de ned as the persistent or recurrent feeling of detachment or estrangement from one’s self. The individual may report
feeling like an automaton or watching himself or herself in a movie (Fig. 12-1). Derealization is somewhat related and refers to feelings of
unreality or of being detached from one’s environment. The patient may describe his or her perception of the outside world as lacking
lucidity and emotional coloring, as though dreaming or dead (Fig. 12-2).