Renal Relevant Radiology: Use of Ultrasound in Kidney

Disease and Nephrology Procedures

W. Charles O’Neill

Abstract
Ultrasound is commonly used in nephrology for diagnostic studies of the kidneys and lower urinary tract and to
guide percutaneous procedures, such as insertion of hemodialysis catheters and kidney biopsy. Nephrologists
must, therefore, have a thorough understanding of renal anatomy and the sonographic appearance of normal Renal Division,
Department of
kidneys and lower urinary tract, and they must be able to recognize common abnormalities. Proper interpretation Medicine, Emory
requires correlation with the clinical scenario. With the advent of affordable, portable scanners, sonography has University School of
become a procedure that can be performed by nephrologists, and both training and certification in renal Medicine, Atlanta,
ultrasonography are available. Georgia
Clin J Am Soc Nephrol 9: 373–381, 2014. doi: 10.2215/CJN.03170313
Correspondence:
Dr. W. Charles
O’Neill, Emory
Introduction decisions (Figure 1). Given its poor precision (5), this University School of
Sonography is an essential tool in nephrology for not measurement should be performed several times. Medicine, Renal
only the diagnosis and management of kidney dis- Division WMB 338,
Since the poor precision stems mostly from under-
1639 Pierce Drive,
ease, but also for the guidance of invasive procedures. measurement, the maximum length is the value that Atlanta, GA 30322.
For this reason, it is essential for nephrologists to should be reported. Measurement of other dimen- Email: woneill@
have a thorough understanding of sonography and its sions is even more imprecise and is of no utility. emory.edu
uses in nephrology. Technological advances over the The same applies to the estimation of kidney volume,
past 15 years have resulted in high-quality scanners which correlates poorly with more accurate tech-
that are both portable and affordable, which has niques (5). Kidney length in adults should usually
greatly expanded the use of point-of-care sonography be between 10–12 cm but varies with body size and,
by clinicians. Although nephrologists have been lagging unfortunately, there are no nomograms for normal
in this area, an increasing number are incorporating kidneys based on large population studies. Nomo-
sonography into their practice, and training programs grams are available for children (2,6). Cortical thick-
are finally starting to meet this need. This review will ness should be estimated in addition to length and is
cover the salient points of renal ultrasonography and its measured from the base of the medullary pyramid to
application to the evaluation of kidney disease and the the edge of the kidney. It generally should be between
performance of invasive procedures. For more complete 7 and 10 mm (7–9) but varies within a kidney, being
coverage, several articles and books directed toward thicker at the poles.When the medullae are not visible,
nephrologists can be found (1–4). one has to rely on parenchymal thickness, which
should be 1.5–2.0 cm, but varies within the kidney.
Sonographic Evaluation of the Kidneys and Accentuation of the lobulation is often a sign of cor-
Urinary Tract tical thinning. Enlargement of the kidney because of
Because of their location, architecture, and limited inflammation or infiltration is often accompanied
spectrum of pathology, the kidneys are ideally suited for by a decrease in the aspect ratio, resulting in a
evaluation by ultrasound. In addition, it is safe, readily more globular shape.
available, easily performed at the bedside or in the office,
and free of radiation. For these reasons, sonography is the Echogenicity
preferred imaging modality and often the only one re- Echogenicity of a structure (acoustic interface) refers
quired. Evaluation includes assessment of the size and to the amount of sound it reflects back to the probe,
shape, the echogenicity, the urinary space (including the which is dependent on the amplitude of incident sound,
lower urinary tract), the presence of masses, and the vas- how much of the sound is absorbed, how much is
culature. Very few findings are specific, and interpreta- reflected, and the angle of reflection. These same
tion, therefore, requires clinical correlation, another reason properties also dictate tissue echogenicity, which is
for the participation of nephrologists in this procedure. the collective back-scatter from numerous microscopic
interfaces and is determined by the micro-architecture.
Size and Shape Increased echogenicity lacks specificity and in histologic
Size is a key parameter that should be measured studies has correlated with interstitial fibrosis, tubular
carefully, since it is the basis for important clinical atrophy, inflammation, and glomerulosclerosis (10,11).

www.cjasn.org Vol 9 February, 2014 Copyright © 2014 by the American Society of Nephrology 373
374 Clinical Journal of the American Society of Nephrology
Figure 1. | Sonographic appearance of the renal parenchyma. (A) Normal right kidney (longitudinal view). (B) Normal right kidney (transverse
view). (C) Echogenic right kidney with prominent medullary pyramids (arrows). (D) Atrophic right kidney (longitudinal view) with thin pa-
renchyma and containing mostly sinus fat. L, liver.
Decreased echogenicity usually results from edema. Cortical
echogenicity can only be evaluated qualitatively and should
be less than the liver or spleen (12). The medulla should have
less echogenicity than the cortex, but the ability to discern
this is dependent on scanning parameters and overlying
structures. Although the lack of cortico-medullary differentia-
tion is frequently mentioned in ultrasound reports, the inabil-
ity to see the medullae is common and not abnormal. Rather,
prominence of the medullae is usually abnormal, generally
indicating increased echogenicity of the cortex (Figure 1C).
Urinary Space
The center of the kidney should be echogenic because of
the presence of sinus fat, and the calyces are not visible
unless dilated (Figure 2). Hydronephrosis appears as
branching, interconnected areas of decreased echogenic-
ity that show sonographic evidence of fluid (see below).
This is usually easily distinguishable from dilated renal
veins but can be confirmed with Doppler ultrasound if
necessary. In cases of hydronephrosis, attempts should be
made to visualize the ureter, which normally is not visi-
ble. The urinary bladder should be imaged in all cases
of hydronephrosis. Volume is estimated from cross-
sectional dimensions on transverse imaging and the lon-
gitudinal dimension in the sagittal plane using the formula
for the volume of an ellipsoid (0.523the three orthogonal
dimensions). The distal ureters can be visible at the base
of the bladder, and dilatation indicates a problem at the
bladder.
Masses
Masses are usually apparent as distortions in the renal
contour or architecture, although this appearance may not
be apparent for masses with echogenicity that matches the
surrounding tissue (Figure 3). Most are benign simple
cysts, which are round and surrounded by a smooth,
thin wall. The fluid is characterized by the complete lack
of echogenicity (i.e., black) and enhancement of the distal
wall and deeper structures because of the lack of sound
attenuation in fluid. Difficulties arise with complex cysts,
which exhibit internal echoes, have some thickening or
irregularity of the wall, or contain septations. The vast
majority of these are minimally complex and do not re-
quire additional imaging (13) beyond follow-up sonogra-
phy. More complex cysts (prominent thickening or
irregularity of the wall) should prompt additional imag-
ing. Cysts are common and are often associated with CKD
(14,15), with acquired cystic disease being the extreme
form. Autosomal dominant polycystic kidney disease
(ADPKD) is the other common multicystic disease, and it
is characterized by severe renal enlargement. Echogenic
masses are usually neoplasms but can also represent hem-
orrhagic cysts, and they often require additional imaging.
Stones typically appear as echogenic foci within the
Clin J Am Soc Nephrol 9: 373–381, February, 2014
Figure 2. | Sonographic appearance of the upper and lower urinary tract. (A) Hydronephrosis of a left kidney (longitudinal view) with dilated
renal pelvis and major and minor calyces. (B) Another longitudinal view of the same kidney showing a dilated ureter (arrows) tracking un-
derneath the lower pole. (C) Transverse view of the urinary bladder (B) showing dilated distal ureters (arrows). (D) Transverse view of the urinary
bladder with an enlarged prostate gland (P).
collecting system that cast acoustic shadows, but either
finding may be absent. A twinkling artifact (nonvascular
color signal) on Doppler imaging has been proposed as an
additional method to detect stones, but it has poor sensi-
tivity and specificity (16).
Vasculature
Although blood vessels can be seen with B-mode
ultrasound, they are usually imaged with Doppler ultra-
sound. A detailed description of renal vascular ultrasound
is beyond the scope of this review and can be found in a
recent review (4). Imaging usually consists of direct visu-
alization of the renal arteries or veins with measurement of
blood velocity and of analysis of velocity waveforms (such
as resistive index) in segmental arteries. Examination of
the renal artery is technically difficult due to poor insona-
tion angles (should be less than 70o), overlying bowel, and
the frequent occurrence of multiple arteries, and requires
significant expertise. It has a high failure rate (up to 30%)
even in expert hands (4). While sensitivity and specificity
can be high, they vary considerably between published
studies (17) indicating that the results are center-specific
and probably reliable only in highly experienced centers.
While intra-renal studies are much easier and angle-
independent, interpretation of the results is problematic.
Renal Ultrasonography, O’Neill 375
Although resistive index is commonly used as an indica-
tion of renal vascular resistance, it is also influenced by a
number of extra-renal factors, including heart rate and
peripheral vascular resistance, and is not specific for renal
disease (4,18). Resistive index has been reported to provide
prognostic information (19,20), but this has been ques-
tioned and may be based on extra-renal, rather than renal,
factors (21).
Diagnostic Applications of Sonography in Kidney
Disease
Sonography is useful in many aspects of the diagnosis
and management of kidney disease. Because the findings
are rarely specific, clinical correlation is essential to the inter-
pretation, an important reason why nephrologists should
be performing these studies.
CKD
Sonography should be performed in all patients with
CKD primarily to recognize advanced, irreversible kidney
disease that would obviate any additional workup, in-
cluding biopsy (11). Signs include small size, thin cortex,
and cysts, but one must be cautious in making the diag-
nosis based solely on size in the 9- to 10-cm range when
376 Clinical Journal of the American Society of Nephrology

Figure 3. | Sonographic appearance of renal masses. (A) Simple cyst in the lower pole of a renal allograft (transverse view). Note the round,
smooth, and thin wall and absence of internal echoes. The distal enhancement (arrows) indicates that it is fluid-filled. (B) Complex cyst in the left
mid-kidney containing echogenic material (transverse view). (C) Solid mass in the right mid-kidney (longitudinal view). Note the echogenicity
within the mass and the lack of distal enhancement. (D) Stone in the lower pole of a left kidney (longitudinal view) casting an acoustic shadow
(arrows). There is also a simple cyst (C).

the kidneys are otherwise normal. Although cortical echo-
genicity is often increased in CKD, normal echogenicity is
not unusual, and echogenicity can increase in reversible
disease. Thus, echogenicity alone is not a reliable indicator
of CKD. Sonography can also identify specific causes, such
as urinary obstruction, polycystic kidney disease, reflux
nephropathy, and interstitial nephritis.
Acute Renal Failure
While sonography can be useful in acute renal failure, its
use should be limited to those patients in whom the cause
is not apparent or in whom urinary obstruction is possible
(22,23). In addition to ruling out urinary obstruction, so-
nography is useful in diagnosing unrecognized CKD. The
kidneys often appear normal in acute tubular necrosis
(ATN) but can be enlarged and/or echogenic. Assessment
of kidney size in ATN is difficult because the baseline size
is rarely known and there is often underlying CKD. In a
study of 26 patients with ATN, only 6 had a renal length
greater than the normal range (24). The aspect ratio was
increased in 12 patients, indicative of swelling, but this
measurement is unreliable and dependent on the plane
in which the kidney is scanned. An increase in kidney
size can also occur in other causes of acute renal failure.
Echogenicity is nonspecific and can increase in other
causes of acute renal failure, including glomerulonephritis
and interstitial nephritis, and can be influenced by fluid
status (12). Increased resistive index is a nonspecific find-
ing that lacks sensitivity in diagnosing ATN (25).
Cystic Kidney Disease
Cystic kidney disease is either genetic or acquired.
ADPKD is the most common genetic type and character-
ized by renal enlargement in addition to multiple cysts.
Hepatic cysts are common but absent in other conditions
that can mimic ADPKD, such as tuberous sclerosis and von
Hippl–Lindau disease. Ultrasound is sufficient to make the
diagnosis, and although the measurement of length is im-
precise, it suffices for prognosis (26). Criteria for the diag-
nosis of ADPKD in subjects at risk have been developed
based on the prevalence of sporadic cysts (27). Acquired
cystic disease is associated with advanced CKD and easily
distinguished from ADPKD on the basis of kidney size.
Sonography can also be useful in identifying infected or
hemorrhagic cysts.
Pain and Hematuria
CT scanning is usually indicated for the workup of pain
and hematuria, but in some cases the diagnosis can be made
by ultrasound and it is not an unreasonable initial study.
Clin J Am Soc Nephrol 9: 373–381, February, 2014
Stones are usually visible, but up to 50% can be missed (28),
particularly when small or within the ureter. Thus, com-
puted tomography scanning is more appropriate for acute
renal colic. Sonography is not indicated in uncomplicated
pyelonephritis, which usually appears as hypoechoic en-
largement of a single lobule caused by edema. Renal infarc-
tion may have a similar appearance but with absent blood
flow on Doppler imaging, although the latter may be diffi-
cult to demonstrate.
Screening for Carcinoma
Certain individuals are at increased risk of renal malig-
nancies, most notably those individuals with prior tumors
and patients with ESRD, even with functioning transplants.
With the exception of ESRD, screening should ideally be
performed with the more sensitive modalities of computed
tomography or magnetic resonance imaging. Whether or
not and how to screen in ESRD remains controversial based
largely on the limited lifespan, and it may be appropriate
only before and after transplantation, although it is not
currently recommended (29). There are no large prospec-
tive studies comparing ultrasound with other modalities
for this purpose. Although sonography may be less sensi-
tive, it is less expensive and does not involve radiation
exposure. Because kidneys with acquired cystic disease
are at particular risk (30), a reasonable strategy may be
the initial use of sonography to screen for cysts.
Transplant Nephrology
Sonography is indicated in most cases of acute renal
failure because of the single functioning kidney and the
frequency of urologic complications. The routine perioper-
ative use of ureteral stents has reduced ureteral obstruction,
but bladder dysfunction remains common. Because of
proximity to the probe and other factors, the urinary space
is often visible in the absence of obstruction, and some
experience is necessary in determining when it is clinically
significant. Sonography is not useful in diagnosing acute
rejection unless it is severe, in which case the allograft is
swollen and echogenic. However, this finding can also be
seen in acute tubular necrosis and nephritis. Doppler ultra-
sound is useful in diagnosing vascular causes of transplant
failure, but these are rare and occur almost exclusively in the
immediate postoperative period. It can be useful in the
diagnosis of transplant artery stenosis as a cause of hyper-
tension. The measurement of resistive indices is of no utility
in differentiating causes of transplant failure and should not
routinely be performed (25).
Procedural Applications of Ultrasound in Nephrology
Because of its ease of use and availability at the bedside,
sonography has revolutionized the performance of percu-
taneous procedures. The enhanced success rates and re-
duced complication rates with ultrasound guidance have
made it the standard of care for many of these procedures,
including those procedures performed by nephrologists.
However, like any tool, success depends on proper use and
an understanding of the limitations. There are two basic
approaches. The entry site, angle, and depth can be de-
termined with ultrasound, after which the needle is placed
without direct ultrasound guidance (ultrasound marking), or
Renal Ultrasonography, O’Neill 377
ultrasound can be used during the needle insertion (real-time
guidance).
Marking versus Real-Time Guidance
Advantages and disadvantages exist to each approach,
and in experienced hands, the success and complication
rates are probably similar. No prospective, randomized
comparisons have been performed. Procedures performed
without real-time guidance depend on careful marking of
the entry site and, for deeper targets, adherence to a
perpendicular angle during the ultrasound marking and
needle insertion. The principal advantage is having both
hands available for the actual procedure. The major dis-
advantage is that sonographic depth is often less than the
true depth, which can result in the needle not being placed
deep enough. Also, matching insonation and insertion
angles is sometimes difficult, and the target may move.
While real-time guidance would seemingly be superior,
needles are difficult to detect by ultrasound. The straight,
smooth surface reflects sound at the angle of incidence and
will only return sound to the probe when maintained
perpendicular to the beam, which is difficult to achieve
(Figure 4A). Although the ends of needles are often rough-
ened so that sound reflects at multiple angles, the increase in
visibility is marginal. Thus, localization of the needle usually
depends on movement of adjacent tissue. However, this
only indicates the presence of the needle, it does not neces-
sarily localize the end, which could be outside the sound
beam and, usually, deeper (Figure 4B). Thus, the probe
must also be moved to be certain of where the needle ends
and to ensure that the needle is not being advanced too far.
Hemodialysis Catheters
Although ultrasound guidance is not essential for cath-
eterization of central veins, it is now considered the
standard of care, markedly increasing success rates and
lowering complication rates (31,32). The site should be im-
aged before the procedure to ensure normal anatomy and
adequate visualization of the target (33,34). The internal
jugular vein is lateral to the carotid artery while the fem-
oral vein is medial to the femoral artery. Sites of previous
catheterizations or attempts should be examined carefully
for venous thrombosis or arterial pseudoaneurysms, and
the internal jugular vein should be imaged down to the
subclavian vein to confirm patency. The vein should be
easily compressible (Figure 5A), and, in the case of the
internal jugular vein, venous pulsations should be easily
visible. If only one vessel is visible, it is far more likely to
be the artery. The insertion path should not include the
artery, which, even when distal to the vein, can be easily
entered even during real-time guidance. It is critical that
the insertion angle and probe placement be adjusted so
that the needle enters the vein within the sound beam
(Figure 5B). Care must be used not to compress the vein
during real-time guidance. It can be avoided by guiding
the needle to the surface of the vein and then puncturing
the vein without real-time guidance.
Percutaneous Renal Biopsy
It is unfortunate that few nephrologists outside of
academic centers perform renal biopsies, despite the fact
378 Clinical Journal of the American Society of Nephrology
Figure 4. | Ultrasound principles of real-time visualization. (A) Needles are specular reflectors from which sounds reflect at the angle of
incidence. Only the sound that strikes at a perpendicular angle returns to the probe. Other sounds may not reach the probe and those portions of
the needle will not be detected. (B) Needles (left) not maintained within the width of the sound beam will appear shallower than (right) their true
depth on the sonogram.
that nephrologists can perform ultrasound-guided biopsies
safely and with high yield (35). In fact, the yield of glo-
meruli in this study was higher than in other published
studies, indicating that biopsies performed by nephrolo-
gists result in higher quality specimens. The great majority
of biopsies not performed by nephrologists are per-
formed by CT-guidance, which results in unnecessary ra-
diation exposure and expense since the success and
complication rates are similar for CT and ultrasound
guidance (35,36). Sonography should be performed be-
fore scheduling a biopsy to ensure that the kidneys can
be adequately visualized and rule out anatomic abnor-
malities (such as lower pole cysts) or advanced CKD
that would preclude biopsy. Even if the kidneys can be
visualized, a depth greater than 10 cm can be problematic
due to the length of the biopsy needles. Since obesity is
more ventral than dorsal, ultrasound guidance is feasible
in many obese patients. Ultrasound guidance should not
be attempted when the kidneys are not well visualized.
There are no randomized studies comparing the out-
comes with ultrasound marking and real-time guidance,
but they are probably similar in experienced hands (36).
The choice of technique should be based on individual or
center preference, experience, and outcomes as well as
patient characteristics.
The angle of insertion and timing with respirations are
critically important for ultrasound marking. For native
kidneys, the patient is prone with back as flat as possible to
assist in maintaining a perpendicular angle. Timing of the
biopsy is dictated by the presence of overlying ribs and
movement of the kidney with respirations. End expiration
is preferable, because it is more consistent; also, the kidney
tends to move deeper with inspiration. The lower pole of
the kidney is localized in both the longitudinal and trans-
verse planes with attention to maintaining a perpendicular
angle (Figure 6), and the depth is noted. The sonographic
depth is usually 1.5–2 cm less than the actual biopsy depth
because of pressure from the ultrasound probe. In our in-
stitution, the true depth is determined with a spinal needle
that is also used to deliver deep anesthesia. Initial passes
may not be successful, usually because the needle is not
deep enough or the patient’s position or respiratory move-
ment has changed.
Real-time guidance avoids the issues of angle and timing,
thus increasing the accuracy. However, this can also result
in a false sense of security for inexperienced operators.
Attention must be focused on the location of the end of the
biopsy needle, which, if not within the sound beam, can
appear shallower than it is. Reliable localization requires
movement of both the needle and the probe. The tendency
to go too deep is compounded by the fact that a second
hand is not available to hold the biopsy device at the skin
and prevent the further advancement that can easily occur
during activation. This advancement can be avoided by
abandoning the probe during the activation.
The low complication rate of ultrasound-guided biopsies
has been well documented (36) and this procedure is ex-
tremely safe in knowledgeable and experienced hands.
However, major complications do occur, but are rarely
reported in the literature. The author is aware of several
deaths and a number of serious complications from native
renal biopsies, even ones performed under real-time
guidance.
Ultrasound guidance is similar for biopsy of trans-
planted kidneys, except that the patient is in the supine
position. One should avoid entering the peritoneum,
which can be immediately adjacent to the allograft and
often overlie it; it is recognizable by the peristalsis.
Although it is unavoidable in intraperitoneal allografts,
bowel loops should clearly be avoided. The allograft is
Clin J Am Soc Nephrol 9: 373–381, February, 2014 Renal Ultrasonography, O’Neill 379

Figure 5. | Sonographic guidance of central venous cannulation. (A) Transverse view of the anterior neck. The internal jugular vein (V) is
underneath the sternocleidomastoid muscle (SCM). The carotid artery (arrow) is posterior and medial to the vein, and it is positioned outside the
path of a needle into the center of the vein. Right panel shows the collapse of the vein, but not the artery, with compression. (B) The needle
should be offset from the probe and at an angle such that (right) it enters the vein within the sound beam.

often very shallow and easily accessed, but it can be very
deep in obese patients. Due to the difficulty in matching
needle and insonation angles on the abdomen and the
possibility of overlying bowel, real-time guidance is
recommended in these patients and patients with intraperi-
toneal allografts.
Sonography also has a role in postbiopsy management.
Routine imaging immediately after a biopsy is not un-
reasonable but generally not helpful, because small peri-
renal hematomas and pseudoaneurysms can be seen in
otherwise stable patients. In a recent study of ultrasound-
guided biopsy in native kidneys, small hematomas were
noted in 13% of patients. However, the absence of these
findings several hours after a biopsy indicates a very low
rate of subsequent complications and may allow for early
discharge of patients (37). Although sonography should be
performed in cases of pain, hypotension, or laboratory ev-
idence of blood loss, other imaging is often required. Peri-
renal and subcapsular hematomas are easily seen, but
retroperitoneal hematomas may be difficult to discern;
also, their extent cannot be reliably determined. Bleeding
within the urinary space may only be apparent as calyceal
and ureteral dilatation.
Other Applications of Ultrasound in Nephrology
Space considerations prevent a detailed discussion of
additional applications of sonography relevant to the
practice of nephrology and potentially performable by
nephrologists. Foremost among these is in hemodialysis
vascular access, particularly arteriovenous fistulae, for both
planning and evaluation of dysfunction. Others include
insertion of peritoneal catheters (38), diagnosis of tunnel
infections in peritoneal dialysis catheters (39), assessment
of intravascular volume status through examination of the
inferior vena cava (40), and detection of lung water (41).
Ultrasound as a Nephrology Procedure
Sonography is essential to the practice of nephrology; it is
inexpensive and relatively easy to learn, making it an ideal
tool to be incorporated into the practice of nephrology.
With appropriate training, nephrologists can be competent
at both performing and interpreting sonograms (42), and
can provide the clinical correlation that is usually required
for interpretation. However, nephrology has the dubi-
ous distinction of being one of the few specialties or
subspecialties that has not embraced ultrasound and
380 Clinical Journal of the American Society of Nephrology
Figure 6. | Ultrasound marking for percutaneous renal biopsy. The lower pole is positioned directly under the center of the probe in the (A)
longitudinal and (B) transverse planes. Note the absence of sinus fat in the transverse view, indicating that only renal parenchyma will be in the
path of the needle.
incorporated it into its training and practice. Although this
void has been filled to some extent by the American Soci-
ety of Diagnostic and Interventional Nephrology in the
form of training guidelines and certification (43), few
fellowship programs offer training that meets these
guidelines (44). However, comprehensive training is
available (45) along with certification (46), and an in-
creasing number of nephrology practices are incorporat-
ing this procedure. It is hoped that renal ultrasonography
will eventually become an integral component of nephrology
training.
Disclosures
W.C.O. has consultancy agreements with Baxter Healthcare,
Astellas Pharmaceuticals, Synageva BioPharma, Novo Nordisk,
and BioMarin Pharmaceutical; received research funding from
Baxter Healthcare, Genzyme, Amgen, and Synageva BioPharma;
received honoraria from Baxter Healthcare, Astellas Pharmaceuti-
cals, and Amgen; has patents and inventions with Baxter Healthcare;
is a scientific advisor to, or has a membership with, Amgen, Kidney
International, and American Journal of Kidney Disease; and has
other interests/relationships with Emory University Office of
Continuing Medical Education.
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