Professional Documents
Culture Documents
www.dlshsi.edu.ph
SEMINAR II
2. In a resting lymphocyte, B cells and T cells can be distinguished from each other via a simple blood
smear
Answer: False
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3. Which of the following types of antigen presenting cells (APCs) has immunoglobulin that functions as
a receptor, then the antigen is internalized, degraded, and presented to T cells?
Answer: B cell
4. The purpose of C3a, C4a, C5a, the split-products of the complement cascade, is to:
Answer: Cause increased vascular permeability, contraction of smooth muscle, and release of
histamine from basophils (Anaphylaxis)
5. Given the following results, what is the immune status of the patient?
HBsAg: negative HBeAg: negative
Anti-HBc: positive Anti-HBs: positive
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6. Which of the following are useful serological tests to document antecedent Streptococcal infections?
I. ASO II. anti-DNAse III. M-antigen IV. Hemolysin
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7. A cause of FALSE-POSITIVE results in the rapid plasma reagin (RPR) test for syphilis is:
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11. Which category of hypersensitivity best describes hemolytic disease of the newborn due to Rh
incompatibility?
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12. The principal difference between cytotoxic (type II) and immune-complex hypersensitivity (Type III) is
Answer: The site where antigen-antibody complexes form
14. An elderly woman presents with chronic fatigue, difficulty sleeping, a rapid heartbeat, and bulging eyes.
Lab tests revealed autoantibodies to thyroid-stimulating hormone. The most likely diagnosis is
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15. An individual is known to have chronic hepatitis disease. Which serological marker should be monitored
to determine if the blood contains the infectious virus?
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16. IgA is largely responsible for protection of the respiratory and intestinal mucosal tract.
Effective protection is dependent on the action of secretory piece which
Answer: Is a poly- immunoglobulin transport receptor on mucosal epithelial cells
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COLLEGE OF MEDICAL LABORATORY SCIENCE
City of Dasmarinas, Cavite, Philippines
www.dlshsi.edu.ph
17. Goodpasture’s syndrome is characterized by glomerulonephritis in genetically susceptible individuals.
The responsible antigen is
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18. An ASO titer and a Streptozyme test are performed on a patient’s serum. The ASO titer was negative,
showing hemolysis in all patient tubes. The Streptozyme test is positive, and both the positive and
negative controls react appropriately. What can you conclude from these test results?
Answer: The patient has an antibody to a streptococcal exoenzyme other than streptolysin O
23. Which part of the radial immunodiffusion (RID) test system contains the antisera?
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24. The absorbance of a sample measured by ELISA is greater than the highest standard. What corrective
action should be taken?
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25. A patient was suspected of having a lymphoproliferative disorder. After several laboratory tests were
completed, the patient was found to have an IgM k paraprotein. In what sequence should the laboratory
tests leading to this diagnosis have been performed?
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26. What has happened in a titer, if tube Nos. 5–7 show a stronger reaction than tube Nos.1–4?
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27. The directions for a slide agglutination test instruct that after mixing the patient’s serum and latex
particles, the slide must be rotated for 2 minutes. What would happen if the slide were rotated for 10
minutes?
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28. What is the most likely explanation when antibody tests for HIV are negative but a polymerase chain
reaction test performed 1 week later is positive?
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29. Interpret the following results for EBV infection: IgG and IgM antibodies to viral capsid antigen (VCA)
are positive.
Answer: Current infection
30. An antinuclear antibody test is performed on a specimen from a 55-year-old woman who has
unexplained joint pain. The IFA result is a titer of 40 and a homogeneous pattern. The appropriate
follow-up for this patient is:
Answer: Retest ANA in 3–6 months
31. Which of the following conditions will most likely result in a false-negative DAT test?
Answer: Insufficient washing of RBCs
32. A patient deficient in the C3 complement component would be expected to mount a normal:
Answer: Type I and IV hypersensitivity response
33. Recombinant Immunoblot Assay (RIBA) is a new method designed to detect which of the following
viruses?
Answer: Hepatitis A virus
34. Cholesterol is added to the antigen used in flocculation tests for syphilis to:
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36. The serologic test for syphilis RECOMMENDED for detecting antibody in cerebrospinal fluid is:
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COLLEGE OF MEDICAL LABORATORY SCIENCE
City of Dasmarinas, Cavite, Philippines
www.dlshsi.edu.ph
38. Which of the ff is considered as the reference method for serological tests for syphilis?____________
39. Titer refers to the ___ dilution of serum which still produces a visible reaction with a particular Ag
a. Lowest
b. Highest
c. Equal
d. none of the above
41. This type of immunization involves administration of vaccines (killed or attenuated microorganisms) to
recipients. They are unable to cause disease but are still immunogenic.
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42. A family of glycoproteins produced by all animal cells that exert virus non-specific but host-specific anti-
viral activity:
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43. The random movement of antigen or antibody to form antibody-antigen complexes in a semi-solid
medium occurs in:
Answer: Precipitation
44. The first antibody to be observed in an HIV infected individual is a directed against:
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46. The chemical basis of specific antigen-antibody reaction is explained by what theory?
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47. What method of gel precipitation is able to detect serologic identity of antigen-antibody system reacting
in adjacent wells? __________________________________________
48. In an agglutination reaction, if cells are not centrifuged long enough, which of the ff might occur?
a. false-negative result
b. false-positive result
c. no effect
d. tolerable effect and can be ignored
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