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Abstract. The purpose of this study was noninvasive tween the expired tidal volume and the difference be-
assessment of respiratory compliance and resistance in tween a 'plateau' pressure at end-inspiration and the
mechanically ventilated patients with acute respiratory end-expiratory pressure is extensively used to assess
failure (ARF). To this end, flow, change in lung the status and progress of acute respiratory failure
volume, and airway pressure were measured at the pro- (ARF), as well as the efficiency of therapeutic in-
ximal tip of the endotracheal tubes in twenty nine crit- terventions in mechanically ventilated patients [7, 12,
ically ill unselected patients. Eleven had acute exacer- 26, 27]. Although airway occlusion at the end of the
bation of chronic obstructive pulmonary disease mechanical inflation also enables determination of
(COPD), 8 had adult respiratory distress syndrome total respiratory resistance [14, 26] to date changes of
(ARDS) and 10 had ARF of various etiologies. Static respiratory resistance in patients with ARF have not
compliance (Cst,rs), 'intrinsic' P E E P (PEEPi), as well received the same attention. Few measurements of
as minimum and maximum resistance (Rrs,min and respiratory resistance have been reported for mechan-
Rrs,max, respectively) were obtained with end-in- ically ventilated patients, and are not routinely used in
spiratory and end-expiratory airway occlusions. We clinical practice to evaluate the efficiency of therapy
found that: (1) PEEPi was present in all patients with (e.g. bronchodilators, aspiration of bronchial secre-
COPD (up to 11.4 cmH20 ) and it was not uncommon tions, etc.) as well as the progression of the disease.
in patients with ARF without history of chronic air- Bates et al. [2] have also shown, in line with the clas-
way disease (up to 4.1 cmH20 ). (2) Without correc- sical analysis by Otis et al. [19] and Grimby et al. [11],
tion for PEEPi average Cst,rs was not significantly that rapid occlusion o f the airway during constant
different between ARDS and COPD patients, whereas flow inflation provides not only measurement of resis-
the average corrected compliance was significantly tance, but also determination of frequency-depen-
lower in ARDS patients. (3) Substantial frequency- dence of resistance, namely a way to quantify the
dependence of resistance was exhibited not only by degree of time constant inhomogeneities within the
COPD patients, but also by ARDS patients. lung. Their results, however, were based mainly on a
model analysis [2] and limited to a small number of
Key words: Acute respiratory failure - Mechanical
patients [22] and required further validation. We
ventilation - Respiratory resistance - Static respira-
therefore undertook this study to extend previous
tory compliance - Positive end-expiratory pressure
(PEEP) - Chronic obstructive pulmonary disease observations [22, 23] and to validate the approach by
(COPD) - Adult respiratory distress syndrome Bates et al. [2]. In fact, time constant inhomogeneities
(ARDS) within the lung might play an important role in deter-
mining gas exchange impairment in critically ill pa-
tients [11, 19].
The measurement of the static compliance of the total
respiratory system (Cst,rs), computed as the ratio be- Methods
* A preliminary report was presented at the joint meeting SEP-
SEPCR, Paris, September 3rd, 1986. Twenty nine unselected, consecutive, patients with
** Currently on sabbatical leave from the Universityof Cincinnaty ARF of different etiology (Table 1) who needed ven-
548 M. Bernasconi et al.: Respiratory mechanics in mechanically ventilated patients
Group I 11 91.5 45.2 7.43 0.43 0.68 1,3 2.6 0.61 6.3
COPD +28.7 _+6.5 +0.07 +0.11 _+0.16 _+0.2 _+0.6 +0.12 +2.2
Group II 8 69.6 39.6 7.43 0.58 0.67 1.3 2.3 0.56 10.0
ARDS +15.9 +6.4 -+0.06 +0.21 _+0.14 +0.3 +0.8 +_0.14 +4.1
Group III 10 79.9 42.5 7.41 0.44 0.70 1.2 2.6 0.60 5.6
Others _+14.0 +15.5 _+0.04 +0.08 _+0.20 -+0.3 _+1.0 _+0.19 +1.4
Definition of abbreviations: VT=tidal volume; Ti=inspiratory time; TE=expiratory time; Vi=constant inspiratory flow;
PEEP = positive end-expiratory pressure. Values are mean ± SD
M, Bernasconi et al.: Respiratorymechanics in mechanicallyventilated patients 549
Flow o.5 /
(l.S-1) oI._f-~ \, ]
Vo,ume
(i)
Occlusion
f----
!'\
Release
ls
iPrnax
A rway !I
Opening
f ....
Pressure --/-1/
(cmH20) -PEEP
Fig. 1. Tracings of flow, volume and pressure at the airway opening in a mechanically ventilated patient with ARDS with PEEP of
8.5 cmH20. Airway occlusion at end-inspiration was performed at point indicated by the arrow. This results in an immediate drop of
pressure from a peak value (Pmax) to P1 thereafter decreasing gradually to a 'plateau' value representingthe end-inspiratoryelastic recoil
pressure of the total respiratorysystem (Pel,rs). In this subject, expiratoryflow became nil before the end of expiration, and inspiratoryflow
started synchronouslywith the onset of the positive pressure inflation, indicating that the end-expiratoryPel,rs relative to PEEP is zero
dotracheal tube via a cone, and to a differential respiratory muscles as well as equilibration between
pressure transducer (Validyne MP 45, + 2 c m H 2 0 ; alveolar and airway opening pressure. Under these
Validyne Co., Northdridge, Ca). After the initial rise, conditions the end-inflation Pao plateau represents
inspiratory flow was constant throughout most of the the elastic recoil pressure of the total respiratory
inflation, Volume (V) was obtained by electrical in- system (Pel, rs) at end-inflation [28]. After the plateau
tegration of the flow signal (Model 8815A; Hewlett- in end-inspiratory Pao during the occlusion was
Packard, Waltham, Ma). A pneumatically operated achieved, the expiratory line of the ventilator was
valve (No. 4200 Hans Rudolph, Kansas City, Mo) was disconnected and the occlusion rapidly released, such
used for rapid occlusion at the airway opening. that the patient expired freely to the atmosphere
Pressure at the airway opening (Pao) was measured through the measuring equipment until zero flow was
proximally and distally to the valve using 2 differential reached or expiration was interrupted by spontaneous
pressure transducers (Validyne MP 45). Equipment inspiratory efforts. In all patients we also determined
dead space (not including the endotracheal tube) was the end-expiratory Pel,rs by means of the end-ex-
70 ml. All signals were recorded on a six channel pen piratory occlusion [20]. The difference between end-
recorder (Gould-Brush 2600; Gould Instruments, expiratory Pel,rs and P E E P set by ventilator, when
Cleveland, Oh) at a paper speed of 25 or 50 mm/s. present, was termed 'intrinsic' P E E P (PEEPi) [23].
The static compliance of the total respiratory
system (Cst,rs) was computed as the ratio between tidal
Procedure and data analysis
volume and Pel,rs minus PEEP, as well as the ratio be-
After insertion of the pneumotachograph and valve tween tidal volume and Pel,rs minus PEEP minus
into the circuit, mechanical ventilation was resumed PEEPi. Inspiratory resistance was measured during the
with the ventilator settings prescribed by the primary same maneuver according to a previously described
physicians. After a few minutes of routine ventilation, method [2, 22]. Briefly, maximum respiratory
the patient appeared to be relaxed and only occa- resistance (Rtot, max) was computed dividing by the
sionally triggered the ventilator. Spontaneous flow immediately preceding the occlusion Pmax-Pel,rs.
breathing efforts were easily detected by on line in- Minimum respiratory resistance (Rtot, rain) was com-
spection of "~, V, and Pao records. At the time of the puted dividing by the flow Pmax-P1. The pressure drop
study, one patient was sedated (morphine) and four due to the endotracheal tube and measuring equipment
patients were paralyzed (pancuronium). No patients was then subtracted to obtain intrinsic respiratory
were sedated or paralyzed for the purpose of the study. resistance, both maximum (Rrs,max) and minimum
Before the end of the mechanical lung inflation (Rrs,min). Since the pressure-flow relationship of en-
with constant inspiratory flow, the airway opening was dotracheal tubes has been shown to be curvilinear, the
occluded until, after the initial drop from the peak pressure drop was calculated at any given inspiratory
value (Pmax) to a lower value (Pl), a plateau in Pao flow. In line with the analysis by Bates et al. [2], the dif-
was observed (usually less then 1.5 s) (Fig. I). This ference between Rrs,max and Rrs,min may represent
plateau provided further evidence of relaxation of the the frequency-dependence of resistance [11].
550 M. Bernasconi et al.: Respiratory mechanics in mechanically ventilated patients
Definition of abbreviations: PEEPi = 'intrinsic' positive end-expiratory pressure; Cst,rs = static respiratory compliance; R t o t , m a x and
Rtot,min = m a x i m u m and m i n i m u m respiratory resistance, including endotracheal tubes and measuring equipment; Rrs,max and
Rrs,min = intrinsic m a x i m u m and m i n i m u m respiratory resistance. Values are mean + SD. Note that values of Cst,rs have been corrected
for PEEPi. Mean values of P E E P i come from 3 ARDS patients and 4 patients in group III
Mean value from three determinations was used was the case only for the corrected values of Cst,rs, i.e.
for each respiratory variable. Group values are after subtraction of PEEPi. In fact, a positive Pao at
presented as mean _+ SD. Statistical analysis of the end-expiration during regular ventilation, reflecting
data was made with the unpaired t-test. A p < 0.05 was PEEPi, was found in 17 of the 29 patients. All COPD
accepted as significant. patients exhibited PEEPi, up to 11.4 cmH20, the av-
erage value amounting to 5.1 + 3.2 cmH20. Because 5
Results patients were receiving P E E P set by the ventilator, that
mean value probably underestimates the true amount
Average results of respiratory mechanics in the three of PEEPi; in fact P E E P set by the ventilator may
groups are given in Table 3. In all the groups mean replace PEEPi [24]. Also 3 and 5 patients in groups II
Cst,rs was lower than normal [1], the lowest com- and III respectively, without any history of chronic
pliance being exhibited by ARDS patients and averag- airway obstruction, exhibited PEEPi. This was less
ing 0.033 +0.007 1/cmH20. It was significantly lower than 2 cmHaO with the exception of two patients,
than both other groups (p < 0.05), while no significant nos. 23 and 29, in whom it amounted to 2.3 and
difference was found between group I and III. But this 4.1 cmH20, respectively. When Cst,rs was computed
without the correction for PEEPi, average values
amounted to 0.033±0.006, 0.0032_+0.008, and
2:0 1.6 1A 1.2 x/
0.042±0.0201/cmH20 in group I, II, and III, respec-
0.08
tively. It has to be noted that without the appropriate
correction for PEEPi patients with ARF due to COPD
iii or ARDS exhibited almost identical values of com-
e~
pliance. The mean ratio between the corrected and un-
0.06 f , j / corrected value of Cst,rs was 36% in the COPD group,
up to 100%, and less than 5°70 in the other two groups.
However individual data reached an error of 20°70 and
, , ' 6 , ' /
40°70 among the ARDS and other patients, respec-
~O 0.04 tively. The relationship between individual measure-
ments of corrected and uncorrected Cst,rs is shown in
Figure 2.
/y,'o Average values of resistance are also shown in
0.02 Table 3. Using a similar method, i.e. the end-in-
J
, ,,', • COPD
, ,,,,, o ARDS spiratory occlusion during a constant flow lung infla-
o
,,,,, * others tion. Not surprisingly the highest value of Rrs,min was
found in patients with COPD, while in the other two
0 I I I I i I I I groups mean Rrs,min was lower and almost the same
0 0,02 0.04 0.06 0,08
C s t , rs ( I. cmH20-l)uncorreeted for PEEP z (Table 3). The absolute difference between Rrs,max
and Rrs,min, which may represent the frequency-
Fig. 2. Relationship between individual values of static respiratory
compliance (Cst,rs) corrected and uncorrected for the 'intrinsic' dependence of resistance [2, 11], averaged (1SD)
P E E P (PEEPi). Solid line is the identity line and dashed lines are 7.2+_3.3, 5.5+2.9, and 2 . 8 + l . 0 c m H 2 0 . l - ~ . s in
isoplets of corrected to uncorrected Cst,rs ratio groups I, II, and III, respectively and was significant-
M. Bernasconi et al.: Respiratory mechanics in mechanically ventilated patients 551
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Acknowledgments. Supported by the National Research Council, Hyperinflation: intrinsic PEEP and its ramifications in patients
Bilateral Project and Cardiorespiratory Group grants 85.00532.04 with respiratory failure. In: Vincent JL (ed) Update in intensive
and 86.00132.04, and the Ministry of Education, Italy; and by the care and emergencymedicine. Springer, Berlin Heidelberg New
Medical Research Council of Canada, and by grant no. HL-27617 York, p 192
from the National Heart, Lung, and Blood Institute. We wish to 18. Montaner JSG, Tsang J, Evans KG, Mullen JBM, Burns AR,
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