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Dual-Port Planar Antenna for Implantable


Inductively Coupled Sensors
Mohammad H. Behfar, Lauri Sydänheimo, Shuvo Roy and, Leena Ukkonen

pressure sensing [2]–[5]. This type of sensor usually consists


Abstract- Passive implantable sensors have received of a capacitive sensing element which is connected to an
considerable attention for wireless in vivo measurement of inductive coil to form an LC resonator, whose resonance
physiological parameters in challenging locations of the frequency varies as a function of the quantity being measured
human body. They are considered promising alternatives (e.g. pressure, temperature, strain, etc.). The wireless
to the existing catheter-based biomedical transducers and measurement is established through the near-field inductive
battery powered implants. In this study, we report a novel link between the implant and an externally coupled reader
planar reader antenna for wireless interrogation of LC- antenna. Previous studies mostly focused on the development
based passive implantable sensors. The antenna utilizes of the sensor [1],[6]–[9]. However, further investigation
two planar, electromagnetically isolated loops for wireless should be carried out on the improvement of the external
detection of the resonance frequency of the LC sensors. 2D reader. In those studies, the external reader is a single loop to
and 3D versions of the antenna with the identical geometry measure the resonance frequency of the sensor using phase dip
were developed for a comparative study. A comprehensive technique. This type of reader loops benefits from simplicity
analysis of the antenna together with in vitro evaluation of in analysis, design and fabrication. However, with this reader
the antenna performance is presented. With the proposed design, isolation of the weak signal received from a small
antenna topology, the isolation level of 58 dB within the implant is challenging [10]. A possible approach to tackle this
frequency range of 1-50 MHz, and at least 37 dB up to 100 issue is to use RF circulators to separate the signal flow in
MHz was achieved. The 3D version of the antenna concurrent excitation and acquisition while using a shared
demonstrated improved performance by the T/R isolation reader loop. Unfortunately, this approach suffers from signal
of at least 64 dB and 44 dB within the frequency bands of leakage between the transmitter and receiver paths as well as
1-50 MHz and 50-100 MHz, respectively. the insertion loss of the signal traveling through the circulator
ports [11]. The impact of the insertion loss is critical when
measuring the resonance frequency of miniature implants in
Index Terms— Implantable passive sensors, orthogonal coils, deep. In addition, low frequency (<100 MHz) circulators are
decoupled coils, planar antenna, T/R isolation, LC sensors. bulky and expensive[12].
To overcome the limitations of the single loop approach,
I. INTRODUCTION Talman et al. [13] designed a novel orthogonal-coil RF probe
for implantable passive sensors. The proposed probe consists

T HERE is an increasing interest in the utilization of LC


passive sensors to enable wireless measurement of
physiological parameters in inaccessible locations of
the human body [1]. These devices are intended to provide
cost-efficient and long-term monitoring of vital signs in
of two orthogonally oriented rectangular loops. The
orthogonal geometry of the loops provides 90 dB T/R isolation
within the frequency range of 1-100 MHz, which is sufficient
for detection of miniature implanted sensors. Despite the RF
patients with chronic diseases without the need for an probe exhibiting a significant improvement in signal detection
implanted battery. Most common biomedical applications of from miniature biomedical sensors compared to the single
the passive sensors include intraocular pressure (IOP) loop approach, it requires costly precision machining process
monitoring for glaucoma, intracranial pressure (ICP) to fabricate perfect 3D orthogonal loops. In addition, with the
monitoring in patients with severe traumatic brain injury, overall dimensions of 65×65×250 , it can be cumbersome
evaluation of progressive spinal fusion and, cardiovascular for hand-held and wearable applications. Thus, an alternative
design should address the size, cost efficiency and ease of
fabrication of the RF probe.
Manuscript received March 18, 2017; revised May 22, 2017; accepted In this paper, we propose a dual-port planar RF antenna for
August 24, 2017. wireless interrogation of the LC sensors. The proposed
This work was supported by the Academy of Finland, the Finnish Funding
Agency for Technology and Innovation (TEKES), Jane and Aatos Erkko
antenna uses two separate loops for excitation of and
Foundation and, US FDA Grant P50 FD003793. acquisition from the sensor. The proposed antenna is a suitable
M. H. Behfar, L. Sydänheimo and L. Ukkonen are with BioMediTech alternative to the RF probe reported in [13]. An innovative
Institute and Faculty of Biomedical Sciences and Engineering, Tampere antenna topology is proposed to provide T/R isolation with a
University of Technology, Finland.(e-mail: mohammadhossein.behfar@tut.fi).
S. Roy is with the Department of Bioengineering and Therapeutic
planar geometry. A comprehensive analysis of the antenna is
Sciences, University of California, San Francisco, USA. presented. Moreover, in order to assess the interaction of the

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Transactions on Antennas and Propagation

Fig. 2. Equivalent circuit of the proposed 2D/3D planar antenna and


the LC sensor. The transmit and receive loops are illustrated in black
and gray, respectively. The dashed arrows indicate the mutual
inductance between each segment of the planar antenna and the
Fig. 1. (a) 2D dual-port planar antenna (top view) (b) Bottom view of
sensor as defined in Section II.
the planar antenna. (c) Graphical illustration of the current flow in the
transmit loop. (d) The LC resonator (the passive sensor).
current, a symmetric pattern of opposing magnetic fields is
antenna with tissue, it was tested in a specific measurement created around and loops as shown in Fig.1 (c). The
setup using postmortem porcine tissue. In addition, a 3D opposing magnetic fields ( ⃗ = − ⃗) induce currents of
version of the antenna was developed and a comparative study the equal magnitude in the opposite directions in the receive
was conducted. In this study, the performance of the antenna loop. Thus, the sum of the induced current is zero, and
in detecting the resonance frequency was assessed using an therefore, the planar loops remain decoupled. The simulated
LC resonator. More specifically, the LC circuit consists of a magnetic field around the antenna with and without the sensor
planar spiral inductor (shown in Fig.1 (d)) connected to a fixed is illustrated in Fig. 3.
value capacitor (C= 8.2 pF) to form a resonance at 32 MHz. For detecting the resonance frequency, the sensor should be
Throughout the text, the term “LC resonator” is replaced with centrally aligned with either of the semicircular loops. Here,
“sensor” for consistency with the concept of the study. A we assume that the sensor is coupled with . When the
complete study on the feasibility of ICP measurement using a sensor is coupled with , the sensor’s impedance is reflected
pressure sensitive capacitor is given in [14]. into the primary, causing the impedance of becomes
higher than the impedance of , and therefore, a greater
II. ANTENNA DESIGN AND THEORY OF OPERATION fraction of the excitation current ( ) flows through . This
A. Antenna topology and principle of operation results in asymmetric magnitude fields around and ,
and consequently, a current proportional to the magnitude of
The proposed planar antenna consists of two separate
the resultant magnetic field is induced in the receive loop.
transmit and receive units. As shown in Fig. 1(a), the transmit
The simulated complex magnitude of the current density in
unit is a symmetric center-tap loop placed on the top of an
the transmit and receive loops is shown in Fig. 4(a-f). As can
FR4 substrate ( =3.3, tan δ=0.002) with the thickness of 1.6
be seen in Fig. 4(a), in the absence of the sensor, the induced
mm. The receive unit is a single turn loop on the other side of
current is an extremely reduced version of the excitation
the same substrate and centrally aligned to the transmit loop.
current. With the sensor coupled with , the current density
Geometric properties of the loops are given in Fig.1 (a), (b),
increases in and the receive loop as the frequency of
and the equivalent circuit of the antenna is shown in Fig. 2.
excitation approaches the resonance frequency of the sensor.
For a detailed analysis of the antenna performance, a
As illustrated in Fig. 4(g), (h), the direction of the current flow
comprehensive simulation was performed using full-wave
in the sensor undergoes 180 degree phase shift in the
electromagnetic simulator (ANSYS HFSS v.15). In the
frequencies above the resonance. The phase shift can be
following analysis, we divide the transmit loop into two
explained by the exchange of capacitive and inductive
semicircular loops denoted by and .
reactance at frequencies below and above the resonance. At
When the unloaded transmit loop is excited with AC
the frequencies above the resonance, the loading effect on

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Fig. 3. Magnetic field around the planar antenna. (a) Without the
sensor. (b) With the sensor coupled with .

Fig. 5. Simulated of the coupled antenna and impedance of the


series RLC sensor.

illustrated in Fig. 2. For exclusive analysis of the planar


antenna, the matching networks are not included in the
following circuit analysis. The impact of the matching
network on T/R isolation is discussed later in Section IV.
Applying the mesh equations for the circuit, the current in
each loop can be expressed by

⎡ + + − ⎤
⎡ ⎤ ⎢ ⎥
⎢ ⎥ ⎢ ⎥
⎢ ⎥ + +
⎢ ⎥
⎢ ⎥= ⎥
⎢ 1
⎢ ⎥ − + −
⎢ ⎥ ⎢ ⎥
⎢ ⎥ ⎢ ⎥
⎣ ⎦ ⎢ − − + ⎥
⎣ ⎦

⎡ ⎤
⎢− ⎥
× ⎢ ⎥ . (1)
⎢ 0 ⎥
Fig. 4. Simulated complex magnitude of the current density in the ⎢ ⎥
transmit and receive loops. (a) Without the sensor. (b) With the ⎣ 0 ⎦
sensor at a distant frequency from the resonance (f=20 MHz). (c)
Coupled with the sensor at a frequency below, but close to resonance where is the source voltage, is the induced voltage in
(f=31.75 MHz).(d) Coupled with the sensor at the resonance the receive loop, is the current flowing in the sensor and,
frequency (f=32 MHz). At resonance, the maximum current is
is the current in the receive loop. and are the resistance
induced in the receive loop. (e). At a frequency above, but near the
resonance (f=32.25 MHz). (f) With the sensor at a distant frequency
of the inductive coil and variable capacitor of the LC sensor
above the resonance (f=50 MHz). (g) Direction of the current flow in model (shown in Fig.2), respectively. R is a 50-ohm resistor
the sensor’s coil at frequencies above the resonance and, (h) at representing the source and load impedances. The inductances
frequencies below the resonance. of each semicircular loops and the receive loop are denoted by
and , respectively. The mutual inductances between each
is reversed, thereby the impedance of becomes less than segment of the planar antenna and the sensor are defined as
the impedance of . Therefore, as can be seen in Fig. following:
4(e),the current with higher magnitude flows through . At
resonance, the phase angle of the current oscillates between : The mutual inductance between each semicircular loop
-90 and +90 degree where the capacitive and inductive and the receive loop.
reactances cancel out each other. At this specific frequency, , : The mutual inductances between the sensor, and
the loading effect on and is exchanged periodically and , respectively.
and, as shown in Fig. 4(d), the maximum current is induced in : The mutual inductance between the receive loop and
the receive loop. sensor.
The induced voltage in the receive loop can be calculated : The mutual inductance between and .
by circuit analysis of the electrical model of the antenna

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Fig. 6. (a) 3D antenna. (b) Graphical illustration of the angular


rotation of the transmit loop about Z-axis. The transmit and receive
loops are separated by 1.6 mm.

Solving the 4×4 system in Eq. (1), the induced current and
voltage in the receive loop are given by

[ ( − )+ ( − )]
= (2)
( + )( − )+2

[ ( − )+ ( − )]
= = (3)
( + )( − )+2
Fig.7. (a) The coated sensor is placed inside the porcine tissue. (b)
Measurement setup for the porcine measurement. (c) The planar
antenna versus the orthogonal-coil RF probe proposed in [13]. (d)
[ ( − )+ ( − )] Graphical illustration of the measurement setup for eddy current test.
| |= (4)
( − )
[ ( − )+2 ] + is a volumed version of the 2D antenna with the identical
geometric properties. The 3D antenna was shaped by laser
cutting the pattern of the loops from an FR4 sheet. Then the
whole volume of the frame was covered by adhesive copper
In view of Eq. (4), | | reaches the maximum value when foil. The basis of the transmit and receive loops are attached to
is maximized. Considering that in a series RLC resonator, the a cardboard with the thickness of 1.6 mm using Blu-Tack
current reaches the highest magnitude at the resonance (deformable pressure sensitive adhesive paste).
frequency [15], for a fixed voltage source ( ), | / | is As discussed in Section II.A, the T/R isolation is the result
maximum at the resonance frequency of the sensor. In this of the symmetric opposing magnetic fields around
study, the resonance frequency of the sensor is detected by semicircular loops. Creation of perfect symmetric opposing
measuring the forward transmission gain ( parameter) magnetic fields requires ideal impedance balance between
between transmitter and receiver, provided that the transmit and .In other words, the current flowing in each
and receive loops are connected to Port 1 and Port 2 of a 50- semicircular loop should be exactly equal to create opposing
ohm VNA, respectively. With the configuration shown in magnetic fields of the same magnitude. However, in practice,
Fig.2, of the antenna can be expressed [16] by fabrication tolerances might distort the impedance balance,
and thereby, causing unequal currents flow in semicircular
= 2 (5) loops. This results in unbalanced opposing magnetic fields,
which causes signal leakage from the transmitter to receiver.
To address this issue, the 3D version of the antenna was
Therefore, the frequency at which the peaks, represents the designed so that the transmit loop can slightly rotate about the
resonance frequency of the sensor. Fig. 5 shows the simulated Z-axis (shown in Fig. 6(b)). Through empirical experiments,
parameter of the antenna when coupled with the sensor. the effective angular rotation found to be less than ±1 degree
to improve the T/R isolation up to 7 dB compared to the 2D
B. 3D version of the antenna antenna. In the prototype developed in this study, the T/R
isolation is tuned by slightly rotating the base of the transmit
A prototype of the 3D version of the antenna was developed loop using a plastic tweezer.
for a comparative study with the 2D version. The 3D antenna

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III. EXPERIMENTAL MEASUREMENT increased in the steps of 5 mm, starting from 5 mm up to 25


mm for the 2D antenna, and 30 mm for the 3D antenna, where
A. Measurement in air
the peak response of parameter disappeared. The sensor
As the first step to verify the performance of the antennas, was coated with 1 mm biomedical grade silicone adhesive
we measured the resonance frequency of the sensor in the air (Nusil, MED-2000) on each side to protect the spiral coil from
over distances from the antennas. The measurements were direct contact with the tissue. The impact of the coating
performed using a 50-ohm VNA with the configuration material on the resonance frequency of the sensor is discussed
mentioned in Section II. The distance between the sensor and in the following section.
reader was increased at 5-mm intervals, starting from 5 mm up
to 35 mm and 40 mm for the 2D and 3D antennas, IV. RESULTS AND DISCUSSION
respectively, where the resonance frequency was not
detectable by the antennas. A. Measuring the resonance frequency
The measured resonance frequency of the sensor in the air
B. Porcine measurement
and porcine tissue with the 2D and 3D antennas is shown in
In order to verify the performance of the reader antennas Fig. 8 (a)-(d). The resonance frequency of the sensor was
when interacting with the tissue in real-life biomedical recognized by searching for a distinguishable peak in the
applications, both 2D and 3D antennas were tested in a magnitude of the parameter. With the 2D planar antenna,
specific measurement setup using a fresh postmortem porcine the resonance frequency of the sensor was measured at the
tissue. According to [17], dielectric properties of the tissue maximum distance of 35 and 25 mm in air and tissue,
used in this study corresponds best to the dielectric respectively. The 3D version of the antenna demonstrated an
characteristics of tissue in a young human. In this improved performance in term of the detection range. With the
measurement setup, the sensor was placed at different depths 3D antenna, the detection range extended to 40 and 30 mm in
inside the porcine tissue through a small incision (as shown in the air and tissue, respectively. This can be explained by the
Fig. 7(a)). The reader antenna was kept very close to the outer enhanced T/R isolation. Moreover, the 3D structure of the
surface of the tissue. Similar to the measurment in air, the loops provides larger effective volume for the near-field
depth at which the sensor was placed inside the tissue was inductive coupling with the sensor [18], [19].

Fig. 8. Measured resonance frequency of the sensor over distances from the 2D antenna, (a) in the air, and (b) in the porcine tissue. (c)
Measured resonance frequency with the 3D antenna in the air. (d) Measured resonance frequency with the 3D antenna in the porcine tissue.

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Fig. 9. (a) Peak response of the paramter as a function of the distance in the 2D and 3D antennas. (b) The impact of the matching network
on the T/R isolation in the 2D antenna. (c) T/R isolation of the 2D and 3D versions of the antenna in the air and in the proximity of the saline
container. (d) Simulated and measured impact of the coating material on the resonance frequency of the sensor.

C. Eddy current and antennas performance


The performance of the dual-port antennas (both 2D and 3D
versions) is characterized by the level of T/R isolation. In fact, To verify that the magnetic fields created by eddy currents
the level of T/R isolation is considered as the base line and, in the human body do not affect the antenna performance, the
when a nearby sensor is coupled to the antenna, the received T/R isolation of both 2D and 3D antennas was measured when
signal from the sensor is added to this base line. Therefore, a the antennas were placed as close as 1 mm to a container filled
highly isolated antenna detects the resonance frequency at a with 0.9 % saline (ɛ =80, ʊ=1.44 S/m [13]). Fig.9 (c) shows
longer distance. Fig. 9 (a) shows the detected resonance T/R isolation in the air and in the proximity of the saline
frequency over the distances from the antennas. As can be container. The T/R isolation in both 2D and 3D antenna
seen from the figure, the 3D antenna with improved T/R slightly decreased when placed near the saline tub. However,
isolation is able to detect the resonance frequency at a longer the isolation level remained sufficient for detecting the
distance. resonance frequency.
B. Impact of the matching network on T/R isolation D. Impact of coating on the resonance frequency of the
We investigated the impact of the matching network on the sensor
T/R isolation. To this end, both transmit and receive loops of As mentioned in the previous section, it is essential to coat
the 2D antenna were matched at 50 ohms within the the sensor to avoid direct contact of the inductive coil with the
bandwidth of 26-33 MHz (around the resonance frequency of tissue as well as biocompatibility issues in the real-life
the sensor) using LC matching networks. Fig. 9 (b) compares applications. The simulated and measured impact of coating
the T/R isolation of the antenna with and without the matching on the resonance frequency of the sensor is shown in Fig. 9(d).
networks. As the graph shows, the isolation level degraded in The agreement between the simulated and measured data
the matched 2D antenna. The severity of this negative impact shows that coating reduces the resonance frequency of the
can be seen near the matching frequency, where the maximum sensor by less than 1 MHz. This can be explained by
power is transferred between the transmitter and receiver. additional parasitic capacitance introduced by the silicon
adhesive ( =2.66, tan δ=0.007).

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V. CONCLUSION [7] L. Y. Chen et al., “Continuous wireless pressure monitoring


and mapping with ultra-small passive sensors for health
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interrogation of the inductively coupled implantable sensors. 2014.
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Implanting in the Eye,” IEEE Trans. Biomed. Eng., vol. BME-
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portable applications. Moreover, since in the inductive Jun. 1954.
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in radio-frequency identification (RFID) tag

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Transactions on Antennas and Propagation

and reader antenna design and wireless system performance


improvement. His current research interests include wireless data
communication and wireless identification and sensing.

Dr. Roy is a professor at the University of


California, San Francisco in the Department
of Bioengineering and Therapeutic Sciences
(BTS), a joint department of the UCSF
Schools of Pharmacy and Medicine, and is a
faculty affiliate of the California Institute for
Quantitative Biosciences (QB3). He is the
director of the Biodesign Laboratory located
on the Mission Bay campus. In addition, he
serves as the Technical Director of The
Kidney Project and is a founding member of the UCSF Pediatric
Device Consortium. He has developed and currently teaches a course
on medical devices, diagnostics, and therapeutics and regularly
lectures on the medical device design process to UCSF graduate
students and to national and international academic and industry
audiences. He is the author of more than 100 publications and co-
author of three book chapters, and holds multiple patents for device
developments.
Before joining UCSF in 2008, Roy co-directed the BioMEMS
Laboratory in the Department of Biomedical Engineering at
Cleveland Clinic in Cleveland, Ohio, focusing on clinical
applications of MEMS. In 1992 he earned a BS degree, magna cum
laude, for triple majors in physics, mathematics, and computer
science, from Mount Union College in Alliance, Ohio. In 1995, he
earned an MS in electrical engineering and applied physics and, in
2001, he earned a PhD in electrical engineering and computer
science, both from Case Western Reserve University in Cleveland,
Ohio.
He is the recipient of a Top 40 under 40 award by Crain’s Cleveland
Business in 1999 and the Clinical Translation Award at the 2nd
Annual BioMEMS and Biomedical Nanotechnology World 2001
meeting. In 2003, Dr. Roy was selected as a recipient of the TR100,
which features the world’s 100 Top Young Innovators as selected by
Technology Review, the Massachusetts Institute of Technology’s
Magazine of Innovation. In 2004, he was presented with a NASA
Group Achievement Award for his work on harsh environment
MEMS. In 2005, Dr. Roy was named as a Who’s Who in
Biotechnology by Crain’s Cleveland Business. In 2005 and 2007, he
was recognized as a Cleveland Clinic Innovator. In 2009, he was
nominated for the Biotechnology Industry Organization's Biotech
Humanitarian Award, which is given in recognition of an individual
who has used biotechnology to unlock its potential to improve the
earth. In 2012, he was presented the Rising Star Award by BayBio
Pantheon, and in that same year, he received the Innovation Pathway
2.0 Award from the Food and Drug Administration (FDA). Most
recently, he was recognized as a Fellow by the Applied Innovation
Institute in 2013.

Leena Ukkonen (M’04) received the M.Sc. and


Ph.D. degrees in electrical engineering from
Tampere University of Technology (TUT),
Tampere, Finland, in 2003 and 2006,
respectively.Currently, she is a Professor and
Academy Research Fellow with the Faculty of
Biomedical Science and Engineering, Tampere
University of Technology (TUT), Tampere,
Finland, and is leading the Wireless Identification and Sensing
Systems Research Group.

0018-926X (c) 2017 IEEE. Personal use is permitted, but republication/redistribution requires IEEE permission. See http://www.ieee.org/publications_standards/publications/rights/index.html for more information.

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