Professional Documents
Culture Documents
IBIS
October, 2011
Agenda
Introduc)on
Tony
O’Sullivan
VP
Opera)ons,
IBIS
Contact
Informa)on
12
Roszel
Road,
Suite
A207,
Princeton,
NJ
hQp://www.ibisworks.com
609.520.8502
Medical
Image
Data:
Basics
DICOM
Standard
MRI
(Magne)c
Resonance
Imaging)
CT
(X-‐ray
computed
tomography)
PET
(Positron
emission
tomography)
Ultrasound
etc.
File
structure
Mul)ple
files
(slices)
per
scan
Each
file
contains
image
plus
DICOM
“header”
(metadata)
Not
fully
self-‐describing
-‐
addi)onal
metadata
may
be
required
Wide
variety
in
number
of
files
per
scan,
and
in
file
size
10,000
5
1
250
Compounds
Traditional
Clinical
Trial
Process
Pharma
Company/Sponsor
CDMS
2006
–
07
Web-‐based
solu)on
Ownership
of
the
data
Secure
Image
Data
Transfer
over
HTTP(S)
Applet-‐based
Standards-‐based
manifest
file
(e.g.
CDISC
ODM)
Data
Quality:
rules-‐based,
repeatable
Integra@on
with
CDMS
Integra@on
with
DICOM
worksta@ons
for
image
review
Image
data
storage
on
the
file
system
Evolution:
2
2008
Oracle
11g:
storage
of
the
image
data
in
the
database
using
Oracle
Mul)media
DICOM
No
more
file
system.
Storage
of
the
image
data
in
DICOM
objects
on
the
database
Enhanced
quality
conformance
checking
Streamlined
data
backup/archive
process
2009-‐10
SOA-‐based
Web
Services
Comprehensive
REST
API
for
data
upload,
normaliza@on,
valida@on,
download,
and
review
SOA-‐based
Adapters
with
JMS
Messaging
Integra@on
with
3rd
party
systems,
DICOM
Worksta@ons
Automated
analysis
of
image
data
with
plug
and
play
algorithms
Automated
alerts
for
outliers
or
specified
criteria;
mobile
review
Validation/Performance
Test
2011
Performance
Test
Summary
Measured
five
major
processes
using
REST
Services:
data
upload,
extract/
normalize,
validate,
download,
view
Representa@ve
sample
of
image
data
from
five
modali@es
–
MR,
PET,
CT,
Ultrasound
and
Mammography
Increased
user
connec@ons
from
25
to
50
to
100
to
800
as
we
increased
database
nodes
from
1
to
2
to
4
Results
Summary
Scalability
From
25
to
800
concurrent
users
–
almost
zero
performance
degrada@on
From
one
to
four
database
nodes,
performance
gain
averaged
250%
Data
Throughput
Over
800%
faster
than
equivalent
tests
on
commodity
hardware
(1
TB
of
image
data
uploaded
in
under
1
hour)
Performance
DICOM
Viewer:
Sub-‐second
@me
to
first
image
over
DICOM
protocol
for
PET,
CT,
MR
As
user
connec@ons
are
increased,
user
response
@mes
improve
consistently
Use
Cases
Automated
Analysis
Automated
algorithmic
image
processing
Plug
and
play
algorithms
3
-‐
Storage
Scan
4.1
-‐
QC
Medical Image
4.2
Scan
Status
Repository
Software Component:
Scan Services 7.2.3.1
retrieve
1
2
5
Scan
Message
Data/logs
Vendor
PACS
Repository
System
(GE,
JMS
Bus
Siemens,
Agfa,
7.2.3
etc.)
6.1
6.2
7.2.1 Alert
7.1
Use
Case
#2:
Automated
Analysis
Research
Facility,
Medical Image Data Management System
Hospital,
etc
Software Component:
Central Repository
DICOM Listener Service
3
-‐
Storage
Scan
4
-‐
QC
4
Scan
Status
Medical
Software Component: Image Repository
7.2.2
retrieve
Scan Services
8.3
store
1
5
Data/logs
2
Scan
Message
7.2.1/7.2.3
Retrieve/Send
Scan
for
Analysis
Vendor
PACS
Repository
System
(GE,
JMS
Bus
Siemens,
Agfa,
etc.)
6.1
6.2
8.2
Return
result
scan(s)
7.1
Evolution:
3
-‐
Current/Future
2011
Grid:
Distributed
compu)ng
for
Analy)cs
DICOM
Proxy
Seamless
image
transfer
from
source
with
mul@ple
rou@ng
op@ons
Automated
distribu@on
of
data
quality
specifica@ons
and
checking
at
the
source
Security
Profiles
SOA: Web Services Layer
Master
Person
Index
Security: Authorization, Data Access Control
Core Data: Study, Patient, Scan, etc
• DICOM Conformance
• Workflow
Data/DICOM
• Event-based messaging
Repository
Exadata
Q &A