Multi-vessel disease vs.

single-vessel disease in STEMI patients:

Which one has worsened outcomes?

Pramadya Vardhani Mustafiza1 Hendry Purnasidha Bagaswoto2 Nahar Taufiq2,

Budi Yuli Setianto2
1
Resident of Cardiology and Vascular Medicine Gadjah Mada University/ Sardjito
General Hospital
2
Staff of Cardiology and Vascular Medicine Gadjah Mada University/ Sardjito
General Hospital

Abstract
Background: Multi-vessel coronary artery disease patients are often related with
worsened outcomes than single-vessel disease. Those patients are more likely to
have multiple risk factors, poor laboratory parameters, and less favorable long
term outcomes. It is associated with inflammatory process which more severe and
excessive in multi-vessel disease.
Objective: to investigate the impact of multi-vessel disease compared with
single-vessel disease on laboratory parameters and clinical outcomes in patients
with STEMI whom admitted to Dr. Sardjito General Hospital between January
until October 2017.
Method: This is an observational study that includes consecutive patients with
STEMI whom underwent revascularization either primary PCI or fibrinolysis that
continuing with coroangiography evaluation. The data was collected from
SCIENCE (Sardjito Cardiovascular Intensive Care) and ACS (Acute Coronary
Syndrome) Registry from January until October 2017. Variables observed are
MACE (major cardiac adverse event), LoS (length of stay), laboratory parameters
such as PLR (platelet to lymphocyte ratio), NLR (neutrophil to lymphocyte ratio),
and creatinine serum. The patients were divided into group A (single-vessel
disease) and group B (multi-vessel disease).
Result: From our 233 STEMI patients, 97 patients (41.6%) were included into
Group A and 136 patients (58.4%) into group B. There are no significant
differences in MACE (p=0.891), LoS (p=0.85), PLR (p=0.264), and NLR
(p=0.405) between group A and group B. Otherwise, patients in Group B had
significant creatinin serum difference compared with those in Group A (1.45 
0.75 vs. 1.35  0.95, p=0.031)

Conclusion: Multi-vessel disease has significant impact on creatinine serum but

not on other clinical outcomes compared with single-vessel disease.
Keywords: multi vessel disease, single vessel disease, STEMI, MACE