1/29/2018 Formulation Diary

Active Ingredient TAPENTADOL HYDROCHLORIDE (IR Tablet)

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Parameters Details

Structural
Formula

Chemical Name 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2methylpropyl]phenol monohydrochloride

CAS No 175591-23-8

Molecular C14H23NO·HCl
Formula

Molecular Weight 257.8

Appearance -

Solubility It is freely soluble in water, 0.1N HCl and simulated intestine fluid (34 and 35 g/100ml, respectively). It's solubility
decreases at higher pH.

Water Solubility 0.78 mg/mL (Predicted)

Polymorphism -

pKa (Strongest 9.34 - 10.45

Acidic)

pKa (Strongest -
Basic)

Log P 2.87

Identification -

Degradation -
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1/29/2018 Formulation Diary

Parameters Details

Hygroscopic -

Photostability -
study

Melting Point -

BCS Class I

Manufacture of -
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