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Table 1
Medications Used to Treat Manifestations of Polycystic Ovary Syndrome
FDA APPROXIMATE
MANIFESTATIONS MAIN ADVERSE TYPICAL
MEDICATION DESCRIPTION PREGNANCY MONTHLY
TREATED EFFECTS DOSAGE
CATEGORY COST*
First-line
Eflornithine Inhibits hair growth Hirsutism C Mild skin irritation 13.9% $46 (brand) for
(Vaniqa)‡ cream one 30-g tube
applied to
face twice
per day9
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FDA APPROXIMATE
MANIFESTATIONS MAIN ADVERSE TYPICAL
MEDICATION DESCRIPTION PREGNANCY MONTHLY
TREATED EFFECTS DOSAGE
CATEGORY COST*
Second-line
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FDA APPROXIMATE
MANIFESTATIONS MAIN ADVERSE TYPICAL
MEDICATION DESCRIPTION PREGNANCY MONTHLY
TREATED EFFECTS DOSAGE
CATEGORY COST*
CHF = congestive heart failure; FDA = U.S. Food and Drug Administration; GI = gastrointestinal; MI = myocardial infarction; PCOS = polycystic ovary
syndrome.
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*— Estimated monthly cost (unless otherwise noted) to the pharmacist based on average wholesale prices (rounded to the nearest dollar) in Red Book.
Montvale, N.J.: Medical Economics Data; 2008. Cost to the patient will be higher, depending on prescription filling fee.
ǁ— Based mostly on anecdotal evidence; cyproterone acetate plus ethinyl estradiol (drug not available in the United States) has been extensively studied.
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